Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q45066 | 5.6.2.2 | ACT_SITE 121; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00937" | MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYK... | 222 |
Q50L42 | 3.1.1.4 | ACT_SITE 420; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 708; /note="Proton acceptor"; /evidence="ECO:0000250" | MQSIPHSDEADVAGMTHASEGHHGLGTSMLVPKNPQGEEDSKLGRNCSGFEDAQDPQTAVPSSPLLSMASCSSQEGSSPCHLLTVRIIGMKNVRQADILSQTDCFVTLWLPTASQKKLKTRTISNCLHPEWDESFTFQIQTQVKNVLELSVCDEDTLTQNDHLLTVLYDLSKLCLRNKTHVKFPLNPEGMEELEVEFLLEENFSSSETLITNGVLVSRQVSCLEVHAESRRPRKRKKNKDLLVMVTDSFENTQRVPPCQEPCYPNSACFHYPKYSQPQLYAEAPKSHCNFRLCCCGTHRNDPVCQPLNCLSDGQVTTLPV... | 130 |
Q54NG4 | 1.11.1.24 | ACT_SITE 46; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MTKLKVDDQAPDFSGIDQNGKNISLSQFNGKPLVLFFYPKDDSKTCTNEACEFRDKYSSFVNAGADVIGISNDDPESHANFISKNSLPYTLISDKDGEIAKKYGVHKELLFFPGRTTFILNKDHKIIGTHSSLINASSHIQESLKAIDHLKGGTPVH | 12 |
Q4WES2 | 4.6.1.16 | ACT_SITE 379; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 387; /evidence="ECO:0000256|PIRSR:PIRSR011789-1"; ACT_SITE 436; /evidence="ECO:0000256|PIRSR:PIRSR011789-1" | MASSSRSLPSSPAGLVESPSKSMSPNNARPAHRARPPKPNYKHIHRFPLPLDVHPLPPLIPHNPLSLISVVLSYLTYFISPPHQETYAAYFDSATSSVHVTDHKAIQALWEMGFFGKGTLSRSQPSWLEREKKRRGLLGGQTNEELTRQRRTERRELKLERARMEKVAIEKRLKAEAAARESGATTVDQTTATLLTDVASGGTAVTLEKFSLRKAREARMLESRRSKEQENKEPASPSSGQESPSKAVRFSPVVQEKEFASDSATLRLPGLATEAQETSQEELPLKNEEHLQLSNEEAFFLAYGLGVLHVYDHQQKTIIP... | 207 |
Q387Q3 | 1.1.1.205 | ACT_SITE 260; /note="Thioimidate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 358; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000130-1" | MDTVTESSMARAMALMGGIGVIHNNCTVEQQARMVRSVKLYRNGFIMKPKSVSPDVPVSTIRNIKSEKGISGILVTEGGKYDGKLLGIVCTKDIDFVKDASAPVSQYMTRRENMTVERYPIKLEEAMDVLNRSRHGYLPVLNDKDEVVCLCSRRDAVRARDYPNSSLDRNGHLLCAAATSTREADKGRVAALSEAGIDVLVLDSSQGNTIYQVSFIRWVKKTYPHLEVVAGNVVTQDQAKNLIDAGADSLRIGMGSGSICITQEVLACGRPQATAIYKVARYAASRGVPCVADGGLRNVGDVCKALAVGANVAMLGSMIA... | 3 |
H2Y1M2 | 3.1.3.48 | ACT_SITE 338; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50" | MKVAQQSLDEDRPSSLKFLAASVAFQNSTVPACTRLPYTPDPDYILNEEEDSCDVIKESKDNVAPLVKQRTRMKPRGLLERRGSNVALTISLRSGTNIIHLRNSPTNTNPRHRKPLTYLRQASCELTPAALHTKSCDTLQLQQEFWEIPMNHPFEKNFNVAGHGTKNRYRSILPNEHSRVKLPVVNDNDPLSSYINANYIRNVTRSNAAYIATQGPMGNTLDDFWRMAWHEAAASVVMITKLKERKEKCSQYLPMAVGESSTYDDITITVESIQPFEHFTVRKLTLTHVNGESRELNHYWYTSWMDHETPEKTRGLLELV... | 149 |
Q9W354 | 2.7.11.24 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MANYQTAHAQERRIQELDQTVESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFRCHPNIVRLVDIFKASNNLDFYLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAIKFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQDGMLTDYVATRWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKLDIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIRHPYVS... | 104 |
A0A2K1KU82 | 3.2.1.143 | ACT_SITE 266; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 284; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 285; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MVLWEEFLPVKWKESESTYEWSNGLRRALGRLSEGPAVSDVRSGDTFANFLLQVANPDTNRDGAADGVAHYFNERVEFAQSSIFFEKTLPGMVQLVLRLPELLLEQIEQSKKLAENFSEELADSREFESAGVSLPLPLQILHPQHPGIIFITQELAASILSCAFLCLFPVSKRDEYRLPGINMDTVFGGIRGRPSQVHKLHCLVNYFNRVCKSMPQGMISYERKYLANYKALEPAFWIDNHKSLCSFETLDQGMIEDVGCEYAQVDFANKFLGGGVLRMGCVQEEIRFTLSPELIVGMLFLPVMTDNETIEITGSERFSN... | 159 |
Q54HL4 | 3.4.19.9 | ACT_SITE 128; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"; ACT_SITE 240; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607" | MIKLFSLFIYLYLISNLKLINTINNTPVIGILTQPFPSSINIKYGDNYLMASYVKYVESAGARVVPIFYNQDDESLTTIFKQINGILLPGGDVDFKTEIQYVKTLTLIWDYVLDVNINGDYFPLWGTCLGLEEIVSLQAESFDVLTDFNAENYSIPLNFSNIALESKIMKNCPTNIINSLANDPITMNNHHFGISPNTFDNNSLLNQFFNVLATNNDKSGNEFISLIESKDYPIYAIIWHPEKSPYSWYSKDATDHSFNAILACQYMSNFFVNETRKSNHKFNDEEVLFKSLIYNYNPTYTFKETHVEQIYIFNTSTNNT... | 176 |
Q9KSM5 | 3.5.4.5 | ACT_SITE 104; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01558" | MRNRIEQALQQMPASFAPYLRELVLAKDFDATFSAEQYQQLLTLSGLEDADLRVALLPIAAAYSYAPISEFYVGAIVRGISGRLYLGANMEFTGAQLGQTVHAEQCAISHAWMKGEKGVADITINFSPCGHCRQFMNELTTASSLKIQLPKRAAKTLQEYLPESFGPADLGIDSGLMSPVNHGKTSDDDEELIQQALRAMNISHSPYTQNFSGVALKMRSGAIYLGAYAENAAFNPSLPPLQVALAQAMMMGESFEDIEAAALVESATGKISHLADTQATLEVINPDIPLSYLSL | 187 |
A0A804M9K5 | 3.1.1.11 | ACT_SITE 458; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MANKVAVASVIAAVGIVAVIGTIAAVTSAKKAGNNHGGMSASVKLSTVCASTLYPQKCEQSLKPIVNDTSNPEDVLRAAFKVALDEVAAAFQRSVHIGKDAQDNLTRNAMDECKKLLDDATEDLRGMARLKPADVVRHVKDLRVWVSGVMTYVYTCADGFEKPELKEAMDKMLQNSTELSSNALAILTRLGELLPQEAKALNATLPGAGHGRRLLGWQMGEAEEVTSGGRGLPAVNDKLGEIADVANANLKLLSDHAALRGRGVLTTGLVGTFDEIQYGRSGVPPSDFPKWMPASQRRLLQLPGFQRPNKVVAQDGSGDF... | 125 |
A0A804HM56 | 3.4.19.12 | ACT_SITE 83; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 163; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MMSWCAIESDPGVFTELIQQMQVKGVQVEELYSLDMDFLDNLRPIYGLILLYKWRPGEKDDRPVIKDLSPNLFFASQVINNACATQAILSVLMNCPDIDVGPELSVLKEFTKNFPPELKGLAINNSEAIRTAHNSFAHNSFARPEQFVAEEQKVGGKDDGVYHFISYLPVDGVLYELDGLKEGPISLGLCSGGPGDLDWLHMAQPIIQERIDRYSEIEIRFSLMAIVKNRKEMYTAELKELQKKREHLVQQLNEHVGAANKHSPAVEALNKSLAEVTAGIEAVTEKIIMEEEKFKKWRTENIRRKHNYVPFLFNFLKILS... | 175 |
I7EP62 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_00147"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00147" | MRTPVIAGNWKLFKKRAEARELVNGLVSLVKDVQGVEIVVAPVFTVLAAVKGALDGSAIKLAGQDCFWEEEGAYTGEISPGMLVDAGCSHVIIGHSERRQYFGETDETVNRKIKAALKAGLAAIACIGESLAEREAGTTFDVLRTQLNGGLAGLSADDLKDVIIAYEPVWAIGTGKTATDAQAQEAHAFIRGVVSELLGKPAAEAVRILYGGSVKPENIKGLMTQPDIDGALVGGASLKADSFAAIASFSM | 213 |
A0A061GPA5 | 3.5.1.2 | ACT_SITE 136; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 241; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 243; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 291; /evidence="ECO:0000256|PIRSR:PIRSR036936-1... | MEGVPYAYTTSFKTQSFLSSALSSSSIITIHQKRHKTILKSISRRNLVICASSGSSSVVKLLDYGAGNVRSLRNAIHYLGFEIEDVQTPKDILDAERLIFPGVGAFASAMDVLVKTGMAEALCSYIKNDRPFLGICLGLQLLFESSEENGPVNGLGLIPGVVGRFNSSNGFRVPHIGWNALQITKDSEILDDIGDHHVYFVHSYRAMPSDDNKEWISSTCNYGDDFIASIRRGNVHAVQFHPEKSGGKIFCALNVGLSVLRRFLDPKSQGTKNLTQGKASKLAKRVIACLDVRTNDKGDLVVTKGDQYDVREHTKENEVR... | 181 |
F0Z6X9 | 1.11.1.24 | ACT_SITE 45; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MTKLKVGDKAPEFTCKDKDGKDVSLSQFSGIVVLYFYPKDDSSVCTKQACEFRDKYQKFIEAGANVIGVSQDSSASHSQFTSKYSLPFTLLTDKDGQLAKEYGVEKTALFLPGRTTYIIDKNHNIAHIHSSLLNASSHIEESLKIIEKLKNQ | 12 |
Q54N73 | 2.7.10.1 | ACT_SITE 493; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MDTSCVSINQCGFCTYLFNRSIPLAGEGDGAIMFNTMVDSMALGYIFSALYLLFRLQRSYTYLQKSSNNNNGNGNGNGSSNNDIISINSSNGLNRSGVKISQDTLWDKNFGISIDHPRIINSTYFKYTLFVSLWLAFEGLLLLFLPPNSLAYPAFVIIVGTGHIVTDNWVLVFLYGKEDDRFSARRSFYSCTLLYLIICCTTLASFFDDQTMCKKNDCQTFMFQDEYTSLAITVASLVVYTIVLGMTIKRSFLRPTGRIWLLFLMGYNCISSVGALLNILDVDAGYCFLGIAAIIYSFSYGPLLFRTCGNDTNLLRARGE... | 97 |
P0CP36 | 3.1.1.5 | ACT_SITE 1349; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1467; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MSSIPTPPDANGNPLIALAVAVIYAILYVLQGVKYGVSLLTIGIPSCIVRMLQYSLTISLGFPHLLALFAGALLALFFLIRYRYLTRYAQLKESALPPPSPPALASRLLPLDGDGLGLPDSRSQTSSFHNYLDDFLSAIRIFGYLEKPVFHELSRHLQTRRLAAGDTLEIGGGEFWCVVEGKVQVFAPDASSQGTPTPSSDTNSPTRPSFNGYHLLNEVSTGGTLSSLFSILSLFTEDIKLSWKSSADDEGEEEQIFEGAPEQSSAKLRVRRANSDVSQLGPDSIGVRAMDPTPLPESIDSHGDSSVPQRRRERSSSIDA... | 131 |
Q6GPK9 | 2.7.11.1 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPSNARAGNLKDPEVAELFFKDDPEKLFADLREIGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEMEIAAITHGALQGLAYLHNHNMIHRDVKAGNILLTEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITSIELAERKPPLFNMNAMSALYHIAQNESPVLQSNHWSEYFRNFVDSCLQKIPQDRPTSDMLLKHRFLQRERPQTVIMELIQRTKDAVRELDNLQYRKMKKILFQDT... | 99 |
Q8PAB1 | 5.6.2.2 | ACT_SITE 122; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MAETAKEIIQVNLEDEMRKSYLDYAMSVIVGRALPDARDGLKPVHRRVLFAMNELGAHSNKAYFKSARIVGDVIGKYHPHGDQSVYDTLVRMAQPFSLRYLMVDGQGNFGSVDGDSAAAMRYTESRMSRLAHELMADIEKETVDFQPNYDEKELEPTVMPTRFPSLLVNGSAGIAVGMATNIPPHNLTEAINACIALIDTPELDIEGLMEYIPGPDFPTAGIINGTAGIAAGYRTGRGRVRIRAKADVEVADNGREAIVVTEIPYQVNKARLIEKIAELVKEKKLEGISELRDESDKDGMRIYIEIKRGESAEVVLNNLY... | 222 |
A0A9L0T2A1 | 3.1.1.4 | ACT_SITE 168; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 212; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MLLMLMLMMLMLMMLMMLTLMLMLMMLMTTKTSEPQGTSLLPERRHCRARPSPVLHPNHPPSWKLRSVEGDSYPTERPGTLTQLLYHSPAQLLGPLLASPPPRMKSPPLLTLLCLLVALAGGNLVQFGVMIERMTGKPALQYNDYGCYCGVGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSASRRRILCAGRTTCQQQTCECDKRAALCFRDNLGTYNRKYARYPNKLCTGPTPPC | 130 |
P15588 | 1.1.1.49 | ACT_SITE 106; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P11411" | MAEQVALSRTQVCGILREELYQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIEPASFQRLNTHMNSLHHGAQANRLFYLALPPIVYEAVTKNIKETCMSQDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKDELQEAWRIFTPLLHHIEREKTQPIPYVYGSRGPPEADELMKRVGFQYEGTYKWVNPHKL | 6 |
A0A078GCL9 | 2.7.1.11 | ACT_SITE 273; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MEASISLIGSTTKPNLSSLIIPSSSIVLHPRLPLPALRLKKVSVFPRISHRNRLIRAQCSDGLRPEEDDGFVLEDVPHLTTFLPDLPSYPNPLKESQAYAIVKRTFVSSEDVVAQNIVVQKGSKRGVHFRRAGPRERVYFRSDEVKACIVTCGGLCPGINTVIREIVCGLNNMYGVSNILGIQGGYKGFYSKNTMTLTPKVVNDIHKRGGTFLQTSRGGHDTAKIVDNIQDRGINQVYIIGGDGTQKGAEKIYQEVERRGLQVAVSGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVESVENGVGIVKLMGRYS... | 84 |
W5MJI2 | 2.7.10.1 | ACT_SITE 628; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MREVGWGRSSRRLYAPSRGMIALWCALCSCFVIVHGVPAARLPTAQPVEKATVKPTDSLSSEAAFLEDFILGIGDTLDLSCGPQGVSQQVAWFKDGAAVLPSNRTRIGQKVLRIINVSYEDSGVYLCRLAHGGALVSNYTVKVADSLSSGDDEDDEESDDAGEAPYWTRPDRMEKKLLAVPAANTVKFRCAAAGNPTPTIHWLKNGKEFRGEQRMGGIKLRHQQWSLVMESAVPSDRGNYTCVVENKYGTITHTYQLDVLERSPHRPILQAGLPANQTVVVGSDVEFHCKVYSDAQPHIQWLKHIEVNGSRYGPDGVPYV... | 97 |
Q54GE1 | 3.2.1.23 | ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 288; /note="Nucleophile"; /evidence="ECO:0000255" | MKLIVLIFFLLFINLNYCLKIKEQPKVGGIDSEQPTNSFYIENGNFLMNNQGNGGSLNQYQIISGSFHYFRCLPELWVDRLTKMKACGLNTIQTYIPWNVHQPNGFNTELVATNDLIEFLRQAQQIGLNVILRPGPYSCAEWELGGFPYWILEQQPIALRSSDSVFISAVIAYWSRLLPLLEPLLFTNGGPIIMVQVENEYGSYGEDKSYLETLLTLLQKYLGQGDGNGSGVLFHSTDGPSAQMLFGSKLEGVYQTVDFGPMPIEQIQDNFKIQQTFASKPTPPMNSEYYTGWITNWGDASAARTDASVVAQGLDDILSL... | 163 |
Q9UTE5 | 2.7.11.1 | ACT_SITE 417; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRFFNAHKSAEDGNYSETTNAISLKNERQSRDLSVNKHGRMLLTALLENFCQLYDNNPAKSKRLFALICHTLQKIGILEEEYIEELAAVRSNYQDALHHLILQAREAIRLDDAEERLLALPDPTNVFEKFPQETALSKFSVDGLNVRQFRFRDLTLESWLQSRNSRYIEDFEEYSLLGRGGFGSVYHVRNKIDGAEYAMKKINSTFQQMSYSKIFREIKCLAKMDHPNVIRYFSSWVESTTEATQMPIVMSKNSSRVLGTSSYCDVNGMDSIIFEPTESSALTDDILFAEDPGTESIISTSRKSSYSSTTESSNFENLES... | 99 |
A0A3Q2ID54 | 3.2.1.23 | ACT_SITE 187; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 267; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MLGVVRFLSLLLVPLLLGSARGLRNASQRTFKIDYSHNRFLKDGQPFRYISGSIHYFRIPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPQPGQYQFSEDHDVEYFIQLAHELGLLVILRPGPYICAEWDMGGLPAWLLEKQSIVLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPIITVQVENEYGSYFTCDYDYLRFLQKLFHQHLGDDVLLFTTDGIFQKFLKCGALQGLYATVDFGSGINVTAAFQIQRKSEPRGPLINSEFYTGWLDHWGQRHSKAKTDVVASTLYDILASGANVNMYMFIGGTNFAYWNGAN... | 163 |
A0A0K9PW09 | 3.1.1.11 | ACT_SITE 378; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQEEKKPARRETLLMLLLLIAGVVAIFSGTKTTGRNDHIALVQRICKKTLYPSTCHSTLSFPISTIVTTKRTVLDLALTTVNTAIKSIIHARLKIKRLRSLPRSPATKDCLLMLDQSLHILRASRTNLRSVFRVRNRRTRNLRQVRSLLAAAMTHRDSCLSGLDDENVFNSSRSGIKNKIVFSKFLNPMKETLSNALAITNKLLKSSERVIAHRRVSELGLGNPGPDEFVVVCSNGTGDYKTISEAVEAAPSSISHRFVIQISPGVYSENIFIPFQKNNLMFVGSGMNLTVIEGNRNMKDGYTTFNSATLAISGAGFLAR... | 125 |
B6K0T4 | 5.3.1.8 | ACT_SITE 284; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MFQLKCEAKCYDWGRVGRNSLAANFAEAGSDLIVENDKPYAELWMGSHTSGPSFCKQSGKPLSEILDEKTMGPRIFEVYGKTLPFLFKVLSIEKVLSIQAHPDKQLGKKLHALAPEHYKDDNHKPEMAIALTDFSALCGFRPVEQLIEFLNNIPALNEFVGQEAVDEFFKSYKQDQRAALKNLFNVVMRQSNDRIAQYTDKLVAAAEQNPVDFGGKKFGGNSLANLIVRLNKQFPHDIGLFVTLFLNYVSLRPGQAVFLRALDPHAYVSGNIIECMAASDNVIRVGFTPKYKDVNTLVENLTYQTANAEEQLTIPVPFAG... | 214 |
Q0WCK4 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MMSPLKAGDIAPKFSLPDQDGEQISLADFQGQRVLVYFYPKAMTPGCTVQACGLRDNMDELKSAGVEVLGISTDKPEKLSRFAEKELLNFTLLSDEHHEVAEQFGVWGEKSFMGKTYNGIHRISFLIDADGKVEHMFDNFKTNNHHDIVMDYLRQNA | 12 |
Q552C1 | 2.7.11.1 | ACT_SITE 1156; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTSVGTTLIVKPANNSGGSDGNIKNNNNNNNNNNNNNNNNNNSNSGNNSNNNSFIDDQVLHTGYLTKQGGRIQNWKIRWFVLKRGTLSYYLSPINWEYTKPRGVIYLTKKTELKEVDHRNRRHCFAVNPNYISENQSIIQQQQNQPILRSSSDSVNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSKLYPNSTRIYLISAQTVFDKSKWIEMIKLAISSDNSQDSKLKRANHQLEKVKDLVFSNRKGSIPTFPSLLNRTIATESLNDLIKVHLSKKRFYFYHDNLTLPALSYIDSESPVN... | 99 |
Q9VHD0 | 3.1.3.1 | ACT_SITE 145; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MRLQLFFFLGLSVLVSGGESSHDAERRMHPVFSLMGTGSNPIGGGRYKRAMPQIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLGGEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPDAAAQLINSPVGQKLNVIMGGGRENFLPKGVTDSSGAPGRRLDGRNLIDEWKNQHTNSAQYVENRRELLNLSNHTSRVLG... | 141 |
A0A072TYG8 | 3.2.1.52 | ACT_SITE 349; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MMMFHSKPRRTLSPSFIFFFLFFFISLSFASKTTPKHHSQSLTYLWPLPSNFTSGNHSLSVDPLLTLSVIGNGGVASSPILDAAFDRYKGIIFKHAGFEFGKGFVRKLRERISLIAYDVVGLNILVHSDDDELQLGVDESYTLSVSKASESSVAWEATIEAHTVYGALRGLETFSQLCSFDYTTKTVQIQKAPWSIQDKPRFAYRGLMLDTSRHYLPINVIKQVIESMSYAKLNVLHWHIIDEESFPLEIPTYPNLWEGSYTKWERYTVEDAYEIVNFAKMRGINVMPEVDVPGHAESWGAGYPDLWPSPSCKEPLDVSK... | 170 |
O36017 | 2.3.1.181 | ACT_SITE 182; /note="Acyl-thioester intermediate"; /evidence="ECO:0000250" | MNKIQHISFITKKNPLVSYERVGALQNRFVQHYLNYKANKVEQPPKPTIITSQVCPVYTLGRRESSINFTKGFPKAKVVKALRGGQTTFHGPGQILAYPIIDLKSFGLSPREYVSRLEQAIIATCKSFGIEKAHTTKNTGVWVTENDKIAAIGIHLRRNITSHGLALNVSTDLKYFNYIVGCGLYGKNTTSFKDQGVFTDLKSVEKVLVNNLDSFLMSK | 55 |
A9WGI6 | 2.7.1.21 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MTRPSDGGRIEVICGCMYSGKTEELIRRMRQVRIARQSYRIFTPRMDTRYAEGQVASHSGSRLEAITVATMKDILAHAEDAQVVAIDELHLFDDDPAEMVRGCQWLANRGVRVIVAGLDLNYRAEPFPAMMHLLALAEQVDKLYAICVKCGAYATRSQRLIDGKPAPADAPTIVVGGLDMYEARCRTCYEPAV | 88 |
A0A1U8KZN0 | 3.2.1.52 | ACT_SITE 319; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MGKMGSEMLIYVLLLMAGVLASGQSSPVKIWPMPASVSYGHTHLYLTNDFGFSSNYGSEILKDAFDRMLALIKLDHVIDANFSAFNSSSLLQGLHIIISSPNGQLQYGVDESYKLIVPSPEKPAYAHLEAKTVYGALQGLQTFSQLCYFSVTSRVLQIDMSPWTIIDQPRFSYRGLLIDTSRHYLPVPVIKKVIDSMSYAKLNVMHWHIVDTQSFPLEIPSYPKLWDGAYSPSERYTVADAADIVRHLCSKRGINVLAEIDVPGHALSWGTGYPSLWPSKDCQQPLDISNEFTFKVIDGILSDFSKIFNFKFVHLGGDEV... | 170 |
M4E0G7 | 5.1.3.3 | ACT_SITE 176; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 309; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MADQTKNINSPGIFELNNGSLQVKISNFGATITSLSVPDKNGKLADVVLGFDSVDPYVNGLAPYFGCIVGRVANRIKEGKFSLNGADYTLPINNGPNSLHGGNNGFDKKTWEVAGHKKDGDKPFITFKYHSADGEEGYPGAVTVTATYTLTSATTMRLDMEAVPENKDTPISLAQHTYWNLSGHDSGNILDHRIQIWGSHITPVDQHSVPTGELLPVKGTPFDFTEEKRIGERIGEVGIGYDHNYVLDCADQEKDGLKHAAKLRDGESSRVMDLWTDAPGVQFYTGNYVDGVVGKGNAIYGKHAGVCLETQGFPNAINQK... | 211 |
A0A0R0JAD6 | 2.4.1.18 | ACT_SITE 380; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 423; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | IVRSKQYLVTQKPVDLALGYRNPHGYGFCFALRRSIQEGVTSHFKGRAVMTDDKSTMSSTEEDLENIGIFRICPSLKPYKDHFKYRMKRYVDQKKLIEEYEGGLEEFAQATFPVYRNSVYGRWEAQIIGDFNGWDGSNHQIKNQFGVWSIKIPDTDGNSAIPHNSRVKFRFRHGDGVWVDRISAWIKYATPYDGVYWDPPLSERYQFKYPRPPKPKTPRIYEAHVGMSSSEPRINSYREFADEILPHIWANNYNTVQLMAVMEHSYYASFGYHVTNFFAVSSRSTPEDLKYPIDKAHSLGLQVLMDVIHSLASNNVTDGL... | 73 |
P18334 | 2.7.11.1 | ACT_SITE 155; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPPIPSRARVYAEVNPSRPREYWDYEAHMIEWGQIDDYQLVRKLGRGKYSEVFEGFKMSTDEKVVVKILKPVKKKKIKREIKILENLRGGTNIITLLDVVKDPISRTPALIFEHVNNSDFKQLYQTLSDYDIRYYLYELLKALDFCHSQGIMHRDVKPHNVMIDAEKRELRLIDWGLAEFYHPRQDYNVRVASRYFKGPELLVDYQCYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTDELYEYIARYHIDLDPRFNDILGRHSRKRWERFIHAENQHLVTPEALDFLDKLLRYDHAERLTAQEAMGH... | 99 |
B9IJV2 | 5.1.3.3 | ACT_SITE 193; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 323; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKFSASFCFIILVISGCACIDSAMGGEIGIYELKKGNLSMKLTNYGARIISLVLPDKNGKLGDVALGFDTIEEFMNASSPFGATVGRVANRISNAQFTLNGTVYKLPANSGNNTIHGGPIGFSKVVWKVKKYSPDGPVPHIVFAYHSFDGEQGFPGDLLVKTSYTLLGDNQLCITMEAKALNKATPVCLVNHAFWNLGGHNSGDILSEKIQIFASRYLPVDSTLIPTGEIVTVKETPYDFLKPNTIGSRINELPKGYDTNYALDGSGNKKLRKAAIVHDEKSGRAMEILTNQPGVQLFTSNTLNVKGKGGFMYKPHGAL... | 211 |
E1B902 | 2.7.11.1 | ACT_SITE 177; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MALLQNVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGEGREPGPQRWREGRARRGRARCKERRVAVSEAPAERQAPGGDDISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAERLLQHPFTTQHLPR... | 99 |
B7PSP3 | 2.7.10.2 | ACT_SITE 538; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | AWNTIIDTTETVGRLVKQNADLIATHTLDKLSCLILEKRALRKIYLEEHQRIHGELARLRDAVLKSTSEYEKCIENATAAKEKYEDQFMKGRGNRKVEEAKERYLKASRKLHQTHNDYILLLNEAMNYEHHLRTTLLPGLLQYQQTVQQEAIDCWQAVMRDYSRHTDFCSEAFQSVHKKLNESIDFIKSESEYQDFIEKYKSKPIPPIDFHYDESLLNNYVGKLKPEQIAVDEFTIDALRERAMVKKRAVDIIRRERDEIKCQEERINSQLQLLVQPLSSIGSEVPRGLDLDITVNGEQMSVNPNVVLQDEDWFHGVLPR... | 98 |
I3LV50 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 121; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCTIPGSDPLLDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTNSYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC | 130 |
Q86GB2 | 1.8.1.9 | ACT_SITE 502; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MATAVLARPARSLINVVQCVRLIRTQATVMFAKENYEYDLVVIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRGTKWGLGGTCVNVGCIPKKLMHQASLLGEAIHDSQPYGWQLPDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEYVNGLGYFKDDHTVVAVMKNQTERELRAKHVVIAVGGRPRYPDIPGAAEYGITSDDIFSLPQAPGRTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSMVEKGIRFHHRSRPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGR... | 37 |
Q8F7W8 | 1.8.4.12 | ACT_SITE 120; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01126" | MNYEVNKSDEDWKKELTPEQYRILRQKGTEMAFTGALYKNQDKGTYVCAACGAVLFSSDTKYESGSGWPSFYQPVKDGVVDKQKDSSHGMERTEILCSKCGGHLGHVFNDGPRPTGLRYCINSASLKFQKE | 40 |
A0A8M9QC50 | 2.7.10.1 | ACT_SITE 542; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MIFLSAAVSLRMLKSWRLLVLLLILTQLCTVQSRPAVTEQGHIVASSEDEDDDESSSEENKPSSSQELLPMAPRWAQPEKMEKKLHAVPASKTVKFRCQAEGNPIPKLRWLKNGKEFKRDQRIGGYKLREHMWTIIMESVVPSDKGNYTCLVENEYGSINHTYQLDVVERSPHRPILYAGLPANRTAVVGSDVEFVCKVFSDPQPHIQWLKHIRVNGSQLGPDGLPYVRVLKHSGVNSSDTQVLTLYNITEEEGGEYVCKVSNYIGEANQSAWLTVLRHDLQAPTAPSAVPSQSYLEVLIYCIGFFLIFLMVGIATIVKI... | 97 |
Q9HBH9 | 2.7.11.1 | ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFE... | 99 |
Q8VZF4 | 2.7.11.1 | ACT_SITE 196; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MESMVKKLKQNLRTGSWKKKEKSMKKERWFLENGSIFLKELIVDCNGKSIPIRSFTSSQIRKATKNFDLSCFVAEEGFYIWYKGVIEDRSYMIKRFSEYKVTDYRVSEVYKDIVLSARMSNHNNFLKLLGCCLEFPFPVLVFEFAEHGVLNYRGGITVNGEESLLPLSLRLKIGKEIANALAYLHMAFPKIIIYRDVKPLHVFLDNNWTAKLSDLSFSISLEEGKSQIEAEDVLGTYGYLDPLYFATRIVTEYTDVYSFGVFLMVVITGISVYFTGSDGYPVGILGYMKGLAENGKLNEIVYPMIMKEMTSAQRLQVEAC... | 99 |
D8QXC8 | 3.4.19.12 | ACT_SITE 37; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 40; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 236; /evidence="ECO:0000256|PIRSR:PIRSR013503-1" | EPLSVLAAEYELGNPVFKAKIEQLGKTYGAIRRTRGDGNCFFRSFMFAYLEHVLEAEDEREAARVLQNVEQCRNALVSLGYAEFTFEDFLAIFVEQVENALPGKPTSMSIGTLVERCRDQYISNYVIMFFRFVTSSEIRRRAEFFEPFILGISSTTVDQFCKSSVEPMGEESDHVHIIALTDALGVPVRVVYLDRSICDNGKTTDVNHHDFIPGGADAEEQRRENPHVVLLYRPGHYDILYRK | 175 |
D9ISE0 | 3.2.1.52 | ACT_SITE 438; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MGGSEYRVDLVVLSEQKQNCRFGLTFHNLSDQDLNSWGLTFAFDRYILPDSVSNGQLTQIGSFCTLKPEGIVLAANHHYYCEFSIGSNPFRYYSDGFNEAMIDFVVDGQPQRAQVDVTPIVLASPYRERSDIPASLTHAQPLLPKPNHIEVSDHSFTFDEQAGVAIYTDLANSAKAWLLEELQRIHQFTLSSSNSGKIIFKSNPTLDEGAYKLKVSEESIKIEAGSSSGFTHACATLLQLLKRDEATKTMEAVCCSIIDSPRFRYRGMMLDCARHFHSVEQVKRLINLLAHYKLNTFHWHLTDDEGWRVEIKSLPQLTEI... | 170 |
Q81BT6 | 3.4.21.89 | ACT_SITE 37; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 79; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MDMKKEIKRGWGKYILFILVIVIGYHSFTLCKVEGESMQPTLYEEDYVFVNKAVVRLSNLQHGEIVIIKEEDESKYYVKRVIGLPGDVINITNGKVYVNDKKQEEPYTNKDLFNNTQVFYNFQKTKIPPNKLFVMGDNREVSRDSRNGLGYIEEDNIIGKVEFVYYPFSKNENDRISGG | 178 |
Q8CM44 | 5.6.2.2 | ACT_SITE 146; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MSQEMENETKVLSYNIAGKPDIADALKNGVRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVRDGLKPVHRRILHAMNERAWRSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQEFSLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDIEKETVSFSPNYDDTKEQPDVLPANFPNLLVNGSSGIAVGMATNIPPHNLRETIDAVIAVIRNPEITIPEILKIIPGPDFPTSGIIIGGEGLISAYSTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGDLVNEKQIEGISEILDLSD... | 222 |
O84591 | 4.2.1.11 | ACT_SITE 207; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MFDVVISDIEAREILDSRGYPTLCVKVITNTGTFGEACVPSGASTGIKEALELRDKDPKRYQGKGVLQAISNVEKVLMPALQGFSVFDQITADAIMIDADGTPNKEKLGANAILGVSLALAKAAANTLQRPLYRYLGGSFSHVLPCPMMNLINGGMHATNGLQFQEFMIRPISAPSLTEAVRMGAEVFNALKKILQNRQLATGVGDEGGFAPNLASNAEALDLLLTAIETAGFTPREDISLALDCAASSFYNTQDKTYDGKSYADQVGILAELCEHYPIDSIEDGLAEEDFEGWKLLSETLGDRVQLVGDDLFVTNSALI... | 200 |
W1P2U1 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSPNFRTLCLFLIVVIAPAAVKCDLEIGFYDQTCQGAELLVFDAVARAVNANPGIAAGLIRMFFHDCFVRGCDGSVLIDSTAGNSAEKDSPINNPSLRGFEVIDKAKAAIEAVCPKTVSCADVLAFAARDSTALTGGLNFPVPAGRRDGRISIASETFTNLPPPTFNATQLEQSFARKNLTLEEMVTLSGAHSIGRSHCSSFVRRLYNFSSTNQVDPTLDPGYATFLQSQCPFNASTNNVTVVPMDVFTPNDLDVGYYVGLTQHFGLFTSDQTLLTNSSTRPFVEENIVNPGVWAIRFAKAMIKMGKIEVLTGTTGEIRT... | 14 |
D8QS78 | 2.3.1.41 | ACT_SITE 157; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000447-1" | MGLVSVFGSDTDKYYDKLLEGVSGVAPIDRFDASQFPTKFAAQIRDFSAKGYIDGKNDRRLDDCLRYGIVGGKKALEHAGLGGENLDKVDKQRVGVLVGSGMGGLSVFSDGVQSLIERGYRKITPFFIPYSITNMASAMLAIELGLMGPNYSISTACATSNYCFYAAGNSIRRGEADIMIAGGTEAAIIPVGLGGFVACRALSQRNDEPQTVSRPWDKGREGFVMGEGAGVLVLTCDAHHMTDPRADGLGVSTCIEKSLEDAGLSPEEVNYINAHATSTVVGDLAEINAIKKVFSESSDIKINATKSMIGHCLGAAGGME... | 60 |
A0A8V0YEV0 | 2.7.10.2 | ACT_SITE 373; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037281-1" | MCWGGRGAICRVAGGFLGIPLLLQLQARVRSISSILYGEMDDWENNDFIQRLDFSSCGEEGEDRSINEEDTLSSSPIKHCDFQKWNSPLPATPHRKLSEIFLSRTKSWVSPTLKSSPGVSRTHGNAETPLHITWKKLQLCDTPHTPKSLLSKTAFPSPGAKVPPKGFRHLRFTPGADLDDSTQASLVNINPFTPESYRQMLFLPNGKRKAREIRNPDLRGQVKQELLTKRCPLKDSNMVSRYQKEFLELERIGVGEFGSVYKCIKRLDGCVYAIKRSKRPLAGSSDEQLALREVYAHAVLGHHPHVVRYYSAWAEDDHMI... | 98 |
Q6EP33 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASAMASSQSHLDLVQLLIVVVMTMTMLVGGGEALSLDYYAKSCPKAEAAVAAAVKQAMAKDRTVPAGLLRLHFHDCFVRGCDGSVLLDSSGNMSAEKDGPPNASLHAFYVIDNAKAAVEALCPGVVSCADILALAARDAVAMSGGPSWQVPVGRRDGRVSLASETTTALPGPTASFDQLKQAFHGRGMSTKDLVVLSGGHTLGFAHCSSFQNRIQPQGVDPALHPSFAATLRRSCPPNNTARSAGSSLDPTSSAFDNFYYRMLLSGRGLLSSDEALLTHPKTRAQVTLYAASQPAFFRDFVDSMLRMSSLNNVAGEVRA... | 14 |
I1JK63 | 1.11.1.7 | ACT_SITE 62; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVKFTIVVIFLFFMFPIAFADLRVGFYSSSCPRAEQIVGQVVQRRFNRDRSITAALLRMHFHDCFVRGCDASILIDSTRGNQSEKAAGANGTVRGYELIDEIKKALERECPSTVSCADIITLATRDSVVLAGGLKYDVATGRRDGHVSQSSEVNLPGPRSTVSRVLEVFSANGMSLDEMVTLLGAHTVGFTHCSFFRDRLNDPNMDPSLRAGLGRTCNRPNSDPRAFLDQNVSSSMVFDNAFYKQIVLRRGVLFIDQQLALDTLSKGLVTVFAGNNAAFQRSFADAMVKMGNIKVLVGNEGEIRRNCRVFNSAS | 14 |
Q9LT38 | 2.7.11.1 | ACT_SITE 152; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MEPSPSSPPSSPPEILDLDSIKALKILGKGATGTVFLAHDVVSTSSSSSPFAVKLVPKSSASSLRRARWEIEVLRRLSVDSNQNPFLPRLLASFESPEYFAWAVPYCSGGDLNVLLHRQNDGVFSSSVIRFYVAEIVCALEHLHTMGIAYRDLKPENILIQQSGHVTLTDFDLSRSLKKPLRPHFYQPDPELIIDRKKSRSFSRLISPTAEKNKTGLKKTRSARVNPINRRKTSFSSGERSNSFVGTDEYVSPEVIRGDGHDFAVDWWALGVLTYEMMYGETPFKGKSKKETFRNVLMKEPEFAGKPNDLTDLIRRLLVK... | 99 |
A0A3B3IBJ5 | 2.7.11.30 | ACT_SITE 357; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1" | PVCKDNICLSNCNLSSYCSFTEEICIAIWRKTNETMTVHTMCHHPNLPLEGINPRLLLNFTSRECHMLPQPADEGVMMVCGCQGEQECNDKLIFDKGVIKMDREHISFPTSGFSRLHSKDVIPVVIVSLVPPLLVAMVATAVFYSYRMRRPDKPGPASRSDWPTKRSPELYQVLDHPRGEAGGGVVVLGVEPVINNTKGRCPNKITVGKRIAELLPIKLEDVVGRGRFAEVWRARLLQSDMGGVNSYETVAVKVFPNVEYASWRNECSILSDPTLQHENLVQFLAAEERSLPSDTLRTYWIVLAHYSLGNMQDHLTANTL... | 106 |
E9FZF2 | 2.7.10.1 | ACT_SITE 160; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | LPYDRRWEFPRHRLKLGVQLGAGCFGRVVKAEAVGLKKGSEETVKTVAVKMVRSEANVSAMEALISELKILVYLGSHLNVVNLLGACTKQIHKELLVIVECCRFGNLQTFLINHRTNFVNLVDEFGNLKMQDEMENLISWAFQIARGMGYLVSKKVLHGDLAARNILLADDGIVKVADFGMAKKMYYEENYEKGGQGLMPVKWMAIESLIDRIFSCQSDVWSYGVVLWEIFSLGRVPYPGMDVGHILMKEILKGYRMDKPELAPNFFGEMMADCWKSDPKERPTFSQMEEIICSHMESSVSSDYLNMNAPYAKLNQEKEN... | 97 |
A0A078HFS7 | 3.1.1.11 | ACT_SITE 402; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSSYGKVDEREHVTLEARRKSRKRITIIVVSLLVLVGIVIGAVFGTMANKKSTTVETNDNGDSISVSVKAVCDVTLHKDKCFETVGSAPNASSLNPEQLFIYAVKITIAEATKALNAFSSSGDNTTMHACVELLDLTIDNLENTLTSSQNGDVTLPELVSDLRTWLSSAETYQDTCIETLAESNHPDSKTFGESQLKNATELTSNALAIITWLGKIADSFKLRRRLLSADVAVNFNVGRRLLQSTDLRRVANIVVAKDGSGKYKTISRALKDVPEKSDKRTVIYVKKGVYFENVKVEKTMWNVVVVGDGGDKSIVSGKL... | 125 |
Q74H28 | 3.5.4.33 | ACT_SITE 63; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MSSLKKTPIRDDAYWMGKAIREAAKAAARDEVPIGAVIVRDGAVIGRGHNLREGSNDPSAHAEMIAIRQAARRSANWRLTGATLYVTLEPCLMCMGAIILARLERVVFGCYDPKGGAAGSLYDLSADPRLNHQVRLSPGVCQEECGTMLSDFFRDLRRRKKAKATPALFIDERKVPPEP | 186 |
H2LLN7 | 2.7.10.2 | ACT_SITE 1002; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MLRRRWSKFFRQETCPGPGEAPQTPGIHVYLFWSRDGGTHLSHTSGDVTAEELCIRAAEVVGINPLCHVLFALYNPQTRYWYSPNHIFSPEENCSLLVQYCMRFYFPNWHGLNDKVPLVTRHSLKGGANQKGSTLLDITSLEYLFAQAKHEFVNEVVEMKEVQNEEERSQFKNESLGMAVLHLSHLAIETNSTLPAVARKVSFLQCIPRSFAKNISNDNFLTKIRIRTVFAEFVRSFQQHTVDSRKVTPQEIMYKYISTLEQLAPRFGTETFQVISLKLREDGDGSSSYSNVVHGDSLSKGNSNPLITHEVMVSGIEGLK... | 98 |
Q8EE60 | 3.5.1.88 | ACT_SITE 134; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MAVLDILTIPDERLKRKAQPVKDIEAIQGFIDDLIETMYHTDDGIGLASTQVGSTDAVIVIDLSETRDQPLVLVNPEIVEKSGEYVGEEGCLSIPGYRAKVTRFEKVKVTALDRQGKAIEIETDDFLAIVLQHEIDHLHGKVFIEHLSTLKQQIALKKVRKYA | 183 |
Q9LSR9 | 2.7.11.1 | ACT_SITE 462; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MAPGLDLIWMVISFLLLIHLSSQQETGFSFNGFRQGDLHVDGVAQILPGGLLRLTDTSEQKKGHAFFRQPLVFNSSEPLSFSTHFVCAMVRKPGVTGGNGIAFFLSPSMDLTNADATQYLGLFNTTTNRSPSSHIFAIELDTVQSAEFDDIDNNHVGIDVNSLTSVESAPASYFSDKKGLNKSISLLSGDSIQVWVDFDGTVLNVSLAPLGIRKPSQSLISRSMNLSEVIQDRMFVGFSAATGQLANNHYILGWSFSRSKASLQSLDISKLPQVPHPKMKTSLLLILLLIVLGIILLVLLVGAYLYRRNKYAEVREEWEK... | 99 |
A0A1S3X3U3 | 1.11.1.7 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDSKSFNLSVLALLACLILSFSVPSLAYGKQTTWPPLRVGFYRYSCPSAEAIVKNVVYKAVSRNPGIAAGLIRLHFHDCFVRGCDASVLLDGPNSEKEGVPNKNSLRGFEVVDAAKAQLEAACPGTVSCADILAFAARDSSYKVGKINYDVEAGRRDGRVSIDSETLTNLPSPFVDAKELVKSFARKGMSVDEMVTLSGAHSIGIAHCAVFANRLYPQNNQQNLPIDPEYANFLKSICPPEALTNGTGVANPANLDVLTPNWLDNKYYAALKSKKGLLISDQGLLANPTTAKMVNFNARYGSVWAKKFAAAMIHMGQLDV... | 14 |
Q10057 | 5.3.4.1 | ACT_SITE 51; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 54; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 385; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 388; /note="Nucleophile"; /evidence="ECO:0000250" | MKISNLLAAFLAFSGGFFCASAEVPKVNKEGLNELITADKVLMVKFYAPWCGHCKALAPEYESAADELEKDGISLVEVDCTEEGDLCSEYSIRGYPTLNVFKNGKQISQYSGPRKHDALVKYMRKQLLPTVKPISKDTLENFVEKADDLAVVAFFKDQKLNDTYTEVAEVMKDDFVFAASDDKELAKSLGSNFPGIVAFTKDAAQDSDKLVYTGDWDPASIADFIGVSSIPLLDELNQMTFGKYQQSGLPLGIIFYNSTESRDELYDVFQPLAKKYQDTLRFAFLDAVRYGAVAKQMNVESDWPAFVIANLKSMLKYPFP... | 215 |
Q4WQI1 | 3.4.19.12 | ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 419; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MGSFLRSFRHNGGSTAPSVGAVPAKKEPQPPPMTPLEKRLLDMGPIREDGSDKFYGMENYGNTCYCNSILQCLYYSVPFREAVINYPTRTPIESLEAALAKSLRYPNPNAQLEAEAQAEKQKAANAQRPGMPPNPQQKPEDKDSPEYKKKMALQTLPLLETQNNASSYGMSESLFTSLKDIFESVVGSQSRIGIIRPQQFLEVLRRDHEMFRTAMHQDAHEFLNLLLNEVVANVEAEASKQPPIEKSLPAPETADSVDQSSSTGSKTPNTTRWVHELFEGLLTSETQCLTCEKVSQRDEVFLDLSVDLEQHSSVTSCLRK... | 175 |
A0A7M7N2Y7 | 2.7.10.1 | ACT_SITE 937; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MWLTSLHEILKGDVYFHQNNQLCYVETIAWDDMQPGLVANISMWDEHAQRNCSEHRCHESCNGHCWGPGEEHCQILTLKDCSSTCDYRCRGPTQADCCHRSCAGGCTNSSNAGCLACRQFSLDNTCVETCPRRYEYDRNTFTNVENPNFRYSYGSRCLKDCPNNVLVDGDNCVKVCGPGKKEQDNQCIPCEGVCPSTCDGIGDDGALSSKHIRSKQFDNCTQINGNLIITSHTFTGDAFAGTTPIDPSALEIFRTVKQITGYLSVQGLHQHFTNLSMFSNLERIDGRNLYGEPPFASLAILDNQHLEALSLISLNELKLG... | 97 |
A0A8V1AB34 | 3.1.3.16 | ACT_SITE 176; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 178; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | GRGPLTGCERWRRAVAQRGPFPLPSSPRTAFPSSAELGGTTGGGGRGGGGGPGAGRGGRGDEISGRRAWRQRGGCAGGRAEGGGGRGGEGGGGGEAPRGGSVSQCNISLKKQRSRSIFSTLFCCFRDYNVEPPSTNSTSALPPLVEENGGLQKPPAKYLLPELTASDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPF... | 144 |
A0A0Q3RHH0 | 2.1.1.37 | ACT_SITE 1200; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MEKVPHTAVTTGTKRRRAKPREMADESIEDDRLETEFANDKKESNGATENGDRPIAHKRRKRAAACSNFKEKAFDLSEDDSLVAIKESRVEEEIGAVRLTKTGPEDKKSCRKLIDFILHDENGNAQPFEMSHSDGISITALVMPLDDNMEKDREKGIRCLRFGPIKNWAISGYKQGTAAIWLSTELADYKCVKPASGYRSYFDHFSRKADVCVEVYKKLARSVGGNLQLGLEELLASVVRSINSNRSFNGTVNKDFVISIGEFIYNQLSGLDNTSDKDDETLSELPVLVALRNECTSRIEFNKLPGMTSSETLKIKDGQC... | 47 |
P00817 | 3.6.1.1 | ACT_SITE 90; /note="Proton donor"; /evidence="ECO:0000269|PubMed:1322842" | MTYTTRQIGAKNTLEYKVYIEKDGKPVSAFHDIPLYADKENNIFNMVVEIPRWTNAKLEITKEETLNPIIQDTKKGKLRFVRNCFPHHGYIHNYGAFPQTWEDPNVSHPETKAVGDNDPIDVLEIGETIAYTGQVKQVKALGIMALLDEGETDWKVIAIDINDPLAPKLNDIEDVEKYFPGLLRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYALDIIKETHDSWKQLIAGKSSDSKGIDLTNVTLPDTPTYSKAASDAIPPASPKADAPIDKSIDKWFFISGSV | 188 |
O59812 | 1.1.1.49 | ACT_SITE 238; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P11411" | MLSIIVFGASGDLATKMTFPALFALYVRKIIPEDFQIIGYARSKLSQEAANKIVTAHIPIDDTVGASQKALNTFVEHYKYVPGTYDKPESFEMLNSIIAEKETAPASECTRIFYLVLPPHLFAPVSELIKSKAHPNGMVTRLIVEKPIGFDYKSADAILSDLSKHWSAKDTFKVDHFLGEDMIDGFTAIRFANSMFEPIWNREHIESVRVDFREDFGCEGRGGYFEGAGILRDVVQNHLLQLLTLLCIEEPKSQDAEDIIKCKVDFLKSLHPVSKEDIVYGQYTKSANGKVPGYRELDGVADDSEVSTFCALQLRSEAPR... | 6 |
A9WIJ8 | 2.7.1.23 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MLERVAVLYNPLSDASIKLSRELADWLVERGVKTTRGVSQEFRDQPHLVADCDLMIALGGDGTVLRAARLCFPHNIPVLPVALGHLSFMAEIGPDEVYSGCEQIMNGGGWFDERSLVRAQLWRGGQKLSQHTALNEVVISRSDLSRIVNVHVTIDDSPLTTYHADGVIVATATGSTAYALAAGGPIVDPRSQALVLVPIAAHLTNIPSMVLHEDAVVTMQLRSRHHALLAVDGRENIDLIEGDEVVVRRSPQVCTFVRLRPSNQFYTQLVARLRRS | 89 |
P40233 | 2.7.11.1 | ACT_SITE 131; /note="Proton acceptor" | MSGQNNVVGVHYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYYFGQEGLHNILVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLERLNTTEDENFDWNLLNNGKGWQSLKSRNAETENQRSS... | 99 |
A0A0A0KP96 | 3.1.1.11 | ACT_SITE 196; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEFLFLHSFFFSTFFLLCFSAAANHHWIGPTGHRLIKVNVKGGSDVFLSVQAAVDSVPDYNTVNTIIRISPGYYVEKVVVPATKPYITFEGGGKETTVIEWHDRAGDRGPSGQQLRTYRTASVTVFANYFSARNISFKNTAPAPLPGMQGWQAAAFRISGDKAYFSGCGFYGAQDTLCDDAGRHYFKECYIEGSIDFIFGNGRSMYKDCELHSIATRFGSIAAQDRNSPIEKTGFAFLRCKVTGSGPVYVGRAMGQYSRIVYAYTYFDDVVAHGGWDDWDHVSNKNKTVFFGVYKCWGPGASKVKGVSWAKELEYKEAHP... | 125 |
Q9VR61 | 2.7.11.1 | ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 694; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MPLADSQKDLRQQPQQQQQQQHVSSTSSSNNAEQQCSSSGLGLQLRQRMQITSSGCSSLAVTPMEHTPTEDDESGGGNSGVTSSVTTVTSSQRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTLCPPPELMELSDSESQGGVETGGRREGATGRSAPDLEDTEPLYETENEFELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGI... | 99 |
O65355 | 3.4.19.9 | ACT_SITE 155; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"; ACT_SITE 268; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607" | MWSYVWLPLVALSLFKDSIIMAKAATILLPSQTGFDISRSPVCSAPDPNLNYRPVIGILSHPGDGASGRLSNATDASSIAASYVKLAESGGARVIPLIFNEPEEILFQKLELVNGVILTGGWAKEGLYFEIVKKIFNKVLERNDAGEHFPIYAICLGFELLTMIISQNRDIFEKMDARNSASSLQFVENVNIQGTIFQRFPPELLKKLGTDCLVMQNHRFGISPQSFEGNIALSNFFKIVTTCVDDNGKVYVSTVQSTKYPVTGFQWHPEKNAFEWGSSKIPHSEDAIQVTQHAANHLVSEARKSLNRPESKKVLSNLIY... | 176 |
A5I068 | 3.5.1.88 | ACT_SITE 138; /evidence="ECO:0000256|HAMAP-Rule:MF_00163" | MSTKPILLLGDEILYRISEEIQKSNLDKAKQVINDLHDTIVSFKNRYGFGRAIAAPQIGESVRIIYMHLGDKTHYFINPILEFIGEDTFHLWDDCMSFPGLEVYVERHKKCKVTYKNLSWEDCEMYLEGDLSELFQHEYDHLDGILAVQRAKDLKSFRINKNKSGY | 183 |
O67556 | 2.7.6.1 | ACT_SITE 193; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MNGVKIIAGTSNKTLSEEIAGYLGLRLTDALITTFSDGEIRVQINESIRGYHVYVITSLSNPVNHNLMELLLTLDAVKRSSPKEITAVVPYYAYGRQDRQDKPRTPISAKLVADLIQKAGANRVIVVDLHSPQIQGFFDIPVEHLTAIPVLYDYIRKNVVLENPIVVSPDAGGVKRARDLANKLGCGIGVILKRRPEPNKAEVMDVVGDIEGKEAIIVDDIIDTAGTLVAAANLLVNKGVKRVIACATHGIFSGPAVERLTNSPIEKVIVTNTLPVYEKKFGKLEVVSIAPLIGEAIRRIQEGTSVSSLFT | 114 |
O42900 | 2.7.11.1 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGIQLSTIQTPQFHELFEEELPEYHNERSLGDSHFLRTFRMQDRKGYDVLIKVFVNKLPEISLSSIVNLLKEEQENISYRVPNAVPYIKTLVTLRAAYLVRPYVTHNLYDRISTRPFLELTEKKWIMFQLLKGISDCHRLGVCHGDIKSENILITSWNWAYLSDFSSFKPTYLPEDNPADYGYFFDTSSRRVCNIAPERFVPASQLQPAPLSPAMDIFSLGCVFAELLLEESPLFTLSQLFSYKAHGSYDLQSVLEQIEDKSTQNMILSMLDRDPSQRLSADAYLQKYRGTVFPACFYDTLYDYCIGLVDPSGILSAKQP... | 99 |
Q9CHG2 | 5.3.1.8 | ACT_SITE 190; /evidence="ECO:0000256|PIRSR:PIRSR036894-2" | MKEPLFLNSVLQEKIWGGDHLKEFGYDLPSDKVGEYWAISAHPHGVSTIANGEFKGQKLDQLYASHRELFGDSKKEVFPLLTKILDANDWLSVQVHPDDEYGQKHEGELGKTECWYIISAEPGAEIIYGHNAKSREELAEMIKSGDWDHLLRKVKVKTGDFFHVPSGTMHAIGAGIVILETQQSSDTTYRVYDFDRKNDQGNLRELHIQQSIDVLNIPGDKVPENQFKTEKFADAKITTLVKSNFFDVYKWQIHGDHEFTKVADYTLVSVLDGQGKLTIDGNEYPVEKGAHFILPSNIEKWNLSGQLEIIASNPA | 214 |
V5IQZ6 | 2.4.1.18 | ACT_SITE 359; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 414; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MNDISDNSSNSLANGGTVANSDIPKDGTGVLSIDPWLEPFKDTLKSRYSKAQSWIDTINKTEGGLEKFSRGTEIFGFNVDKDNTITYREWAPNAKQASLIGEFNNWDRNAHRMKKNEFGVFEITIPPTANGQPAIPHNSKIKITLELPDGQWVDRLPAWIKYVTQDLSVSPAYEARFWNPPQSERYTFKHKRPSKPESLRIYEAHVGISSPECKVATYKEFTKTMLPRIKNLGYNAIQLMAIMEHAYYASFGYQVNSFFAASSRYGPPEDLKELVDTAHAMGIAVLLDVVHSHASKNVLDGLNEFDGTDHQYFHGGGRGK... | 73 |
Q6C2N7 | 3.1.1.3 | ACT_SITE 331; /note="Charge relay system"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10037" | MKQDLYKESSPPPSTTKSKGLYVIVAALVTTAIYLLYSQGYSNTHGEKDMPSVVPNLVLPANPSSDHSFAVKHIYHHNTEADANHGRMDVSGEWVRAAQKAQHLNLGQDTHRYMASNARDPYTNLPLKSRTQKVKRWRQRDPDHVESYLEAARLNPQLYGAMDFDWVEEDILVPDVTDRDTVVSLAVMASNAYVDVPFTGDWTNVSWKETGGIGWQSDGVRGHIFVDQTPGSPLVVIALKGTSAAIFDSGGDTVINDKTNDNLLFSCCCARVSYLWNTVCDCYTGESYTCDQECLEKELYAEDRYYRAVLDIYRNVTHLY... | 128 |
A5I7X4 | 1.1.1.100 | ACT_SITE 160; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MGNNMKCLEGRTAIVTGASRGIGRAIAKKLASMGANLVLNYRSSAKEIDTLLEEIEEFGIETLVIQGDVSSFEDSKKIADEAKNKFGTIDILINNAGITKDSLILRMTEEDFDKVISVNLKGVYNCSKHIAPIMLKQRSGKIINISSVVGVAGNAGQCNYAAAKAGVIGITKSLAKELGSRGITVNAVAPGYIRTDMTDALPEKVKKSIEDLLPLKRLGTPEDVAEAVGFLASDKAAYITGQVIHVDGGMII | 2 |
P0A873 | 2.1.1.228 | ACT_SITE 169; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:14583191" | MWIGIISLFPEMFRAITDYGVTGRAVKNGLLSIQSWSPRDFTHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGIDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVSRFIPGVLGHEASATEDSFAEGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA | 43 |
Q01804 | 3.4.19.12 | ACT_SITE 42; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 45; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:25944111, ECO:0000269|PubMed:29395066"; ACT_SITE 148; /evidence="ECO:0000250|UniProtKB:Q5VVQ6" | MEAAVGVPDGGDQGGAGPREDATPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIVMELDTLEVADEDNSEISDSEDDSCKSKTAAAAADVNGFKPLSGNEQLKNNGNSTSLPLSRKVLKSLNPAVYRNVEYEIWLKSKQAQQKRDYSIAAGLQYEVGDKCQVRLDHNGKFLNADVQGIHSENGPVLVEEL... | 175 |
A0A2C9VJ12 | 3.1.1.11 | ACT_SITE 222; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTKEHFVSAQCVLIIILIVAPTVSSDDTTPIPADDAKVRNWFQTNVKPLASRKGTLDPALVAAEGKPKIIKISKDGKGDFRTLTDAIKSIPSGNKQRVIMKIGPGVYTEKITIDMNKPFITFLGAPNAMPTLAFGGTALEYGTVDSASVMVLSDYFMATYIIFKNTAPGPNSKKPGAQAVALRISGDKATFYNCRMLGFQDTLLDERGRHFFKNCYIEGTVDFIFGSGKSLYLETEIHVIDNKGAFITAQAKTKKSEDYGYSFVQCKITGKGSGTYLGRAWKTMPEVVFSYTKMGAVVNPLGWSNNNIPERDSTVFFGEY... | 125 |
P29295 | 2.7.11.1 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYRYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKLEYHNDHLFDWTMLRYTKAMVEKQRDLLIEKGDLNANSNAA... | 99 |
A0A067EV40 | 3.5.4.5 | ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MERPRFVIEAAEAESMAQKSGLTVLQLLPTLVKSAQTLARPPISKFHVGAVGLGSSGRIFLGGNVEFPGLPLHQSIHAEQFLITNLILNAEPRLQHLAVSAAPCGHCRQFLQELRNTSDINICITSINSNERKYHPLSHLLPDRFGPNDLLDKDVPLLLETHQNGMSFNLCNGQIPETENPKERLKYAALEAANKSHAPYSKCPSGVAIMDCEGNIYKGSYMESAAYNPSLGPVQAALVAYLAAGGSGGGGGGYERIVAAALVEKEDAVVRQEHAARLLLQVISPKCEFNVFHCGCKKSCSRF | 187 |
C0LGT6 | 2.7.11.1 | ACT_SITE 849; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKLSFSLVFNALTLLLQVCIFAQARFSNETDMQALLEFKSQVSENNKREVLASWNHSSPFCNWIGVTCGRRRERVISLNLGGFKLTGVISPSIGNLSFLRLLNLADNSFGSTIPQKVGRLFRLQYLNMSYNLLEGRIPSSLSNCSRLSTVDLSSNHLGHGVPSELGSLSKLAILDLSKNNLTGNFPASLGNLTSLQKLDFAYNQMRGEIPDEVARLTQMVFFQIALNSFSGGFPPALYNISSLESLSLADNSFSGNLRADFGYLLPNLRRLLLGTNQFTGAIPKTLANISSLERFDISSNYLSGSIPLSFGKLRNLWWLG... | 99 |
H3G5Z5 | 2.7.11.1 | ACT_SITE 130; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | KWELDDFIVTKNLGQGKFGNVYLAKEKCSNVTVALKVLFKSPLTRDGGVCNLKREVEIQGRLHHPNILRMHGYFYDDSCVYLVLEYAPYGELYKELAREKFFADAVAAHYVGQVVEALKYCHCCNVIHRDIKPENLLLGFNQTIKLADFGWSVYAPKPYNMRKTLCGTPDYLSPEMILGEPHDFRTDSWSLGVLTFELLVGSTPFYCEDQHDMYRRIEMVDYQFPPSPQVSETAKAFIAGLLKRNPKERISLEDAAKHPWI | 99 |
Q9FJ79 | 5.6.2.1 | ACT_SITE 870; /note="O-(3'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130" | MATEAFVKPVVPNGHDGYEDEDEDDIPLVFKRNSNTAATTNRPSPINNAMRNSAIGSTKSSPPMRSPLTSPNRSASSSTRSSMMKPALPSSSSVQRSTLKSPLRDDRSVVAKERNGFGKAPSVSKSDDEDSEDDKPLSARLKLDSKEVTKQPSSSGRGSTQQAVQKSNMRPQGLSDYTKKKVLDERAPMSSTVQTKTSVGTSSSKPVHIEQKRPLVNNIDRNGLKPKTEGHSSQAPAKRPLEKGSSSNQSSVKRPKLSEPARPVKVEQGSHISATQDAKGKNLDASKPLRANQATVKEDNSDGDDHVPIASRMKSDSSNN... | 221 |
Q803Y3 | 3.1.1.3 | ACT_SITE 173; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 197; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 278; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MVEKSLKIALCFLCVILCHSFSAFAAAPDESAPLNEDAENFFPTDSAVLHDKISYNMRKSLDLGDGACYLQPGKKESIVACGFNATLRTILIIHGWTMSGMFESWMHKLVAAVQRRESEANVVVVDWLGLANQLYPDAVNHTRRVGQSIATLLDWLQEEEQLQLENVHIIGYSLGAHVAGYAGTFVNGIIGRITGLDPAGPMFEGADSYNKLSPDDADFVDVLHTYTRGALGVSIGIQEPIGHIDIYPNGGDVQPGCTFGEFLSAASGNFMEAMKCEHERAVHLFVDSLMNKDHVSYAFQCTGPDRFKKGICLSCRKNRC... | 128 |
P28708 | 2.7.11.1 | ACT_SITE 354; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDEYSSIYSQPKTPRLKQEGFPDSIGDQHEKALIDENGEEDKKMASTEGTTGDSRSTPLTVSIPTFENVQALPTPMTYTPLSPGNLSMSPIDQSSLNIPKRRSHARLLDDMLSVTQPNQRVVSELIAPANLSPQRVVSLPTVTEEALVNDSVDSDNYTKEPYFPESSSSTEKCDDDIFQGFLLDHWDRPLLWKKVRPIGSGNFSTVLLYELMDQSNPKLKQVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTRELQVLKSLNHPCIVKLLGINNPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVM... | 99 |
A0A0P0WHC1 | 2.3.2.26 | ACT_SITE 1293; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MESSEMAVIEYVVAELRDEAAGAGAHVAALAALCDVLAVAADHLFDALPIAEFVARLPRLLASGEGDVPLFAARAIAEVCEGVRPWATSFARYGAIEALRDKLLAIDCIELAEECLRALGVISMECPKECLSHGVPAAVLQFFDFFSMHKQKLVLKIVANVLGDFSAKDAAKAMEAAPVLCNLLQSTDKTILDSAVSCLVLVSDGACDSAQHMEKLYELNAVQATMRLMENDGWKSLSDETLSGILGLLKDLASLSARAVKSLFELNICDLLKQMITYYTSSHSDHNKVQTLVELIYYLMPPLEMCDHRTELIIAKKNVI... | 65 |
P9WIA1 | 3.1.3.48 | ACT_SITE 11; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:15743966, ECO:0000305|PubMed:17975835"; ACT_SITE 17; /evidence="ECO:0000305|PubMed:15743966, ECO:0000305|PubMed:17975835"; ACT_SITE 126; /note="Proton donor"; /evidence="ECO:0000305|PubMed:15743966, ECO:0000305|PubMed:17975835" | MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS | 149 |
A0A6I8NUW4 | 2.3.2.26 | ACT_SITE 940; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MATQRKHLVKDFNPHITCYLCKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELQRETEFWKKNKPQENGQGESSKADKPKVDQDGEENEEDKDYHRSDPQIAICLDCLRNNGQSGDNIVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGENFRCLNCSASQVCSQDGPFYQSQGEDRGAKGRLSTLRSFISTINQKKEGAESRGSPPPLAAPSIKNGRERPPICLDVRQKQRVSPDALPPEMKAPTPAEP... | 65 |
Q81GQ1 | 3.4.21.89 | ACT_SITE 40; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 81; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MKKTLKKEGMEWIRTIFIGVLLAVFFRTFFFSTYVVEGKSMMPTLQDGNMLVVNKVSYQVGDLNRFDVVVFHANKKEDYVKRIIGLPGDHIEYKQDKLYINGQFIDEPYLEKYKKEINGRQLTGDFTLEELTKEKLVPPGFIFVVGDNRLGSWDSRHFGFVKADTVVGKVDLRYWPIQEVQTNFSKG | 178 |
T1F578 | 3.4.19.12 | ACT_SITE 90; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MAASAGDWCLIESDPGVFTELICQFGVTGVQVEEIWSLDAESFSFSRQRPIYGLIFLFKWKPDMHLQGNVIRDDRLRDIFFAKQVINNACATQAILSILFNCSDAKIDLGETLNSFKTFTRGFDPTTKGLALSNSDIIRQTHNSFAKQQLFELELENMKKDDEAYHFIGYIPINGRLYELDGLQEGPIDHGVIPEESEWLNYAKLVIEQRIQKYEADEIHFSLMAIIPDQKKHYEALLENTQDLDEVEKYKHLLNAEINKRKQYQVENARRRHNFIPFIIEFFKILAEKGELAELMEKAKVKAKDRANKAKASKPVKDS | 175 |
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