Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q96G74 | 3.4.19.12 | ACT_SITE 221; /evidence="ECO:0000255"; ACT_SITE 224; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:33110214"; ACT_SITE 334; /evidence="ECO:0000305|PubMed:22245969" | MTILPKKKPPPPDADPANEPPPPGPMPPAPRRGGGVGVGGGGTGVGGGDRDRDSGVVGARPRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPPCGGPGGPGGGPGDALGAAAAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGAVGGGSPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTGTSAVEPINTFHGIHQN... | 175 |
O04482 | 3.4.19.12 | ACT_SITE 82; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393, ECO:0000305|PubMed:17559514"; ACT_SITE 157; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393" | MSWCTIESDPGVFTELIQQMQVKGVQVEELYSLDSDSLNNLRPVYGLIFLFKWQAGEKDERPTIQDQVSNLFFANQVINNACATQAILAILLNSPEVDIGPELSALKEFTKNFPSDLKGLAINNSDSIRAAHNSFARPEPFVPEEQKAATKDDDVYHFISYIPVDGVLYELDGLKEGPISLGPCPGDQTGIEWLQMVQPVIQERIERYSQSEIRFNLLAVIKNRKDIYTAELKELQRQREQLLQQANTCVDKSEAEAVNALIAEVGSGIEAASDKIVMEEEKFMKWRTENIRRKHNYIPFLFNFLKLLAEKKQLKPLIEK... | 175 |
Q9JXT8 | 5.3.1.1 | ACT_SITE 99; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MWDQKWVIGNWKMNGRLQNNNALMHRFRIHPTAERVLIGLAAPTVYLLQLHNAMQIVLNNRILTCAQDVSRFPNNGAYTGEVSAEMLADTGTDIVLIGHSERSLYFGEKNEIQRRKMENVLNVGLIPLLCVGESLEEREAGKEHEVIAHQLSILQGLDTKNIAVAYEPVWAIGTGKVATVEQIADMHAFIYKEILSLCGSDVKIRVLYGGSVKADNAADIFAVPYVDGALVGGASLSYDSFTAIISAAQNA | 213 |
Q5AMP4 | 1.1.1.37 | ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MFSKVATRSFSSSASNAYKVAVLGAGGGIGQPLSLLLKLNHKVTDLALYDIRGAPGVAADVSHVPTNSTVKGYNPDQIEEALTGSDVIVIPAGVPRKPGMTRDDLFNTNASIVRDLAKAAADYAPNAAVCIISNPVNSTVPIVAEVFKSKGNYNPNKLFGVTTLDVLRAARFVSEVAGTNPVNENVPVVGGHSGVTIVPLLSQTKHKDLSGETRDALVHRIQFGGDEVVQAKDGAGSATLSMAQAGARFAGAVLDGLAGEKDVIECTFVDSPLFKDEGVDFFSTKVTLGVDGVKTVHPIGEISDYEEAQVKEAKDTLIKN... | 5 |
Q10S66 | 3.2.1.14 | ACT_SITE 91; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P29022" | MRRLLPLAGATLLIAAAGGASGQQAGVGSIITRAMFESMLSHRGDQGCQGAFYTYDAFIKAAGDFPRFGTTGNDETRRRELAAFFGQTSHETTGGWATAPDGPFAWGYCRVNEITPSDPPYYGRGPIQLTHKYNYQLAGDALGLDLVNNPDLVSSDPVVAFRTAIWFWMTAQSPKPSCHDVITNQWTPSGDDRSSGRLPGYGMATNIINGGEECGKGYSTDNAKDRVGYYKRYCDMFRVGYGDNIACRDQKPYGGG | 158 |
H2MMA8 | 2.7.10.1 | ACT_SITE 753; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MDCDLRSPLFLIHLFMSTFLPALCVIYPLNEVNLLDSKASQGELGWISYPSHGWEEISGVDEHYTPIRTFQVCNVMEYSQNNWLRTNWIPRQSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLLYLETDDDQGSHFREHQYLKIDTIAADESFTQTDLGDRILKLNIEVREVGPLTKKGFYLAFQDVGACVALVSVRVYFKKCPYTVRNLASFPDTVPMDSQSLVEVKGSCVNHSKEEEPPRMYCSTEGEWLVPIGKCLCNQGYEERSSTCQTCRAGFYKSGFGNTECSKCPPHSFSHHEGSLHCVCEKNYFRAEGDPA... | 97 |
Q5EBY4 | 2.7.10.1 | ACT_SITE 838; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MEADRSFGLAWVLLLLLGITAATGREVCLGTDMKLALPSSLENHYEMLRLLYTGCQVVHGNLEITHLQGNPDLSFLQEIVEVQGYVLIAHVSVRSLPLDNLRIIRGSQLYKSNYALAVHNNSNSSQAGLGLRELRLRSLTEILLGGVYIWGNPQLCFPRNINWEDTVSKVQNKPLHLQDIPKNCPRCSSACKSGGCWGEKDQDCQTLTSVNCSSGCSRCKGPKPSDCCHVQCAAGCTGPKDSDCLACRHFNDSGTCKDSCPPPTIYDPITFQSKPNKDKKFSFGATCVKQCPHNYLAMEVACTMVCPKANKEVISVEPDG... | 97 |
P47250 | 5.6.2.2 | ACT_SITE 134; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_01897" | MAKQQDQVDKIRENLDNSTVKSISLANELERSFMEYAMSVIVARALPDARDGLKPVHRRVLYGAYIGGMHHDRPFKKSARIVGDVMSKFHPHGDMAIYDTMSRMAQDFSLRYLLIDGHGNFGSIDGDRPAAQRYTEARLSKLAAELLKDIDKDTVDFIANYDGEEKEPTVLPAAFPNLLANGSSGIAVGMSTSIPSHNLSELIAGLIMLIDNPQCTFQELLTVIKGPDFPTGANIIYTKGIESYFETGKGNVVIRSKVEIEQLQTRSALVVTEIPYMVNKTTLIEKIVELVKAEEISGIADIRDESSREGIRLVIEVKRD... | 222 |
A0A022QG17 | 3.1.1.11 | ACT_SITE 383; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MANLLNCSLLLFFLLTLSLSPPSAAEPPPQPPSTACKTTLYPKLCLSILSAFRQSPSNPDNYGKFSVKQCMKHARRLSDTISRFLSTNTKEKSLMGYAEIAALDDCRHLQQLNVDYLGLISGDLKSPPGNMSDVLVDGVRSLLSAVVTNHQTCYDGLADAGSGMADALAAPLGDAAAMYSVALGLVAHALGRGGGRRRWGGGGGVNEWSRIERLIVSRQVLTESGIRINNTVTVSPYGGANFSSINEAVAFAPNNSVVDDGYFVIYARQGYYQEYIVVPKNKKNIMLIGDGINATVITGNRNVIDGWTTFNSATFAVYGE... | 125 |
D8STJ8 | 3.1.3.16 | ACT_SITE 285; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MTDASIRAEAEQLKEQANAAFQACKFSHARELYTRAIELDGSNPVYWANRAFTNVKLEEYGTAIMDATKAIELDRKYVKGYYRRGAAYLALGKFKEGLKDLRQVCKIVPKDPDAMRKIRECENAIKKLRFEEAVASDERRSVAGTIDYSAFVVEDSYTGARIQGQHLDLAFVKQMMQDFKDEKRLHKRYAYQIMREALDLLSSLPSLVEVTIPDKCHITVCGDIHGQYYDLLNIFEMNGLPSNENPYLFNGDFVDRGSFSVEVILTLFAFKCLYPQGIYLARGNHESQSMNKIYGFDGEVKAKYFSDVMPEYFSEIFCAL... | 144 |
Q7XSV1 | 1.11.1.7 | ACT_SITE 86; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALRRMGIILVLLAIATLLSPAVSARFISLPTDHLPITTPPLADGLGFDLYSDSCPQLETTVRSAVQAALQQEIALAAGLLRIFFHDCFPQGCDASLLLTGANSEQQLPPNLTLQPRALQLIEDIRAQVHAACGPTVSCADITALATRDAIVASGGLPYDVPLGRLDSFAPAPSDAVFQLPQPTSDVSTLLSAFQTRNLDNVDLVALSGGHSIGRARCSSFSNRFREDDDFARRLAANCSNDGSRLQELDVTTPDVFDNKYYSNLVAGQGVFTSDQGLTGDWRTSWVVNGFAGNHWWFYGQFGSSMVKLGQLQGPSGNVG... | 14 |
A1A5Q6 | 2.7.11.1 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKRWQVCQDLRSSPFQEDALTDHYRILASLGQGGFGEVKLASHLLTQTKVAIKVLPKSNKNLLLKSEIEIMKSLDHPHIIKLLHIIDTNENIFIVLEHAVGGELLTRIEDFGYLPEEECNRLFRQMVLALQYCHQRGIIHRDIKPENILLDHKGNVKLSDFGLSTKIVMGQKLTTLCGTLPYCAPELFNLNGYDGQAIDVWSLGVVLYYMATGCLPFQGFTYQAIKQKILSGRYSVNFRLSPDLWDVIAKLLTVNPRERPRVHEILRFNWLKNENEVSPSSLGGNTDSHPDPTILVMMGDMGYEQGQIRESLRERKFDQV... | 99 |
O74135 | 2.7.11.1 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSTTSSHSNVVGVHYRVGKKIGEGSFGMLFQGVNLINNQPIALKFESRKSEVPQLRDEYLTYKLLMGLPGIPSVYYYGQEGMYNLLVMDLLGPSLEDLFDYCGRRFSPKTVAMIAKQMITRIQSVHERHFIYRDIKPDNFLIGFPGSKTENVIYAVDFGMAKQYRDPKTHVHRPYNEHKSLSGTARYMSINTHLGREQSRRDDLESMGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQVTPLKELCEGYPKEFLQYMIYARNLGYEEAPDYDYLRSLFDSLLLRINETDDGKYDWTLLNNGKGWQYSAAKQHVVQRR... | 99 |
P68209 | 6.2.1.5 | ACT_SITE 298; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_03222" | MSRQVARLIGSLSSKARRCSTGGSEVFPSCQSLTSLTQSRSFASDPHPPAAVFVDKNTRVLCQGITGKNGTFHTEQAIEYGTKMVAGVTPKKGGTEHLGLPVFNSVAEAKADTKANASVIYVPAPFAAAAIMEGIEAELDLIVCITEGIPQHDMVRVKHALNSQSKTRLIGPNCPGIIKPGECKIGIMPGYIHKPGKIGIVSRSGTLTYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFFVDPQTEGIVLIGEIGGTAEEDAAALIKASGTEKPVVAFIAGLTAPPGRRMGHAGAIVSGGKGTAQDKIKSLNDA... | 247 |
K7LNG1 | 5.1.3.15 | ACT_SITE 144; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 233; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MAYASSTSLGVRLTEGEGNLPKLVLTSPAGSEAEIYLFGGFITSWKVPSGKDLLFVRPDAVFNGNKPISGGVPHCFPQFGPGPIQQVRNPVVTLELKDGPYSCTVWDFSFHALFKVTLNAKSLATELTVKNTDNKAFSFSTTLHTYFQASVSNASVKGLKGCKTLNKDPDPKNPVEVVTFPGFVDCAYLDASSELQLDNGLGDLISIKNTVYAVLWNPYLQMEACYKDFVCVENAKIGSVQLEPEQTWTAVQHLSIA | 210 |
Q9Y7S9 | 3.2.1.1 | ACT_SITE 229; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:16751704"; ACT_SITE 253; /note="Proton donor"; /evidence="ECO:0000305|PubMed:16751704" | MFGVYFVLLFLSSALIHVANAGSNAEWRKRIIYQILTDRFAVDDGSTDNPCDPDANQYCGGTWKGIENKLDYIEDMGFNAIWISPIDKNIEGDIDGAGYAYHGYWNTDYESLNEHFGTEDDLVSLITAAHKAGIWVMLDSIVNSMALAPPLADADYSSLNPFNKESYFHPYCLIDWDITDNETNVMDCWQDSGVLLADLDVESSDVSSYLSDHFKSLISKYDFDGLRIDAVKMMNYTFFPDFVDATGVYSVGEVFSYDPDTMCSYMSVLPGVTNYFLQLYINFSFTATGAGFTLIPTYQEVMASNCSKYDSTLMLTFIEN... | 157 |
A0A8M9QDJ7 | 2.7.11.13 | ACT_SITE 482; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MAPFLRIAFNEFNLGELPPMTEQPFCAIKMKESLSTERGKTLVQRKPTMYPAWKSTFDAHIYEGRVIQVVLMKTAEEALSEATVGVSVIAERCKKGNGHAEFWVDLQPSGKVMMSVQFFVEDTDLDSKASMTAKDDDGILTINRRRGAIKQAKVHFIKNHEFTATFFKQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTMFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGMVKQGLKCEDCGMNVHHKCQTKVANLCGINQKLLAEALNQVSLKSSTKRPDPTLSEIGIYQAIDKN... | 100 |
A0A804IC23 | 2.3.2.26 | ACT_SITE 857; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSLFDAASHPRQPFDHHHHLKRKVDDHDDQDHSFPLLKMARPSSPPFSFPSPCLTPALAAFDVEESKTRLSSSHPPPPFASPSASLPSPSSLPSPPSDELHFFVRLMSRGSLVVHARPTDTVNSVIERIESVTGIPSREQRLIYCGRQLRGESTLRHSAVKKDATLQLTGRLRSTGQSRAWRVVDDLVSSICFLNAAAASDICTVDRQRTVAQLVKDFLNTTLADSDGDKDKALAYLGVFSLAGAPSELVKLYLSPLADNRAIAEGAIRIFLDSNPDFLPVYVHSQCAPIVFTFCRMLAATVGRNDQLYVGCRRTLSKLL... | 65 |
Q12505 | 2.7.11.1 | ACT_SITE 186; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLSDCLLNNFRITAQIGSGAYGLVFHVVDILTSREYAVKTVFKSSSMDEFYNKNGLNNNSQVARTTLLQTQLYHFFKSFQKKLFLPSVDLDSILQLTENELNRLPHYREIAFQLRVQSHGNIVKIHQVLESSIATFIVMDYYDRDLFTSIVDDKHFVNHGILIKKVFLQLCSALDHCHRLGIYHCDIKPENVLLDRNDNAYLCDFGLSTKSKYLAPNVCVGSSYYMAPERILYCLNTTTNGIHVDECCSSLPTDTGDIWSLGIILINLTCIRNPWLKAHQKEDNTFQHFANDNNVLKKILPISDELFTVLTKILQLNPYT... | 99 |
A4D9L0 | 2.5.1.18 | ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MGKKIECYLDCVSPYSFYAFTYLQQNADALASLGVEIEYIPVFLGGINVGSGNKPPWTLPAKAAYSRYDGKRAQKYFGHDFEVPAFFPILSLLPQRALTYIKRKQAHKLVPAFLACFETMWNGQLDISKPENLSKALSKAFSGTEVEEILAAAASPEIKHELTATTERVVKELGAFGCPWFWVTNGEGKSEPFFGSDRFHFMWDFLELPHEDLRLKVDEKAKL | 77 |
A0A2K1IXG2 | 1.11.1.6 | ACT_SITE 140; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 213; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MTFEMATLAPIRGLAPRNSCAPLRAHESSDGLRPSLRGTKLCVKFPAMATDSMKSGRNTILASQNGNGNGNGKSSAQGSAQPCLGNSGKPLYTTLGGHPVSDDNNSLTVGESGTVTLEDLHLFEKNAHFNRERVPERVVHAKGAGAHGYFEVTKDVSDLCKAGLFSEVGKRTPVFARFSTVTGESGYADTARDPRGFSLKFYTEEGNWDMVGNNTPVFFVRDAAKFPDLIHSQKRNPQTHMKDPNAFWDFLSLVPESLHQVLITFSPRGVPDGHRHMHGYGSHTFKWVNKEGKAHWVKFHFISDQGIKNLTHERAVELAG... | 13 |
Q88VW2 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 338; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MEKQVIETVKAREIFDSRGNPTVEADVILSDGTLGRAEVPSGASTGEKEAVELRDGGDRLAGKGVLKAVNNVNTVINHALHGADPFNQAHIDQIMIDLDGTPNKARLGANAILGVSMATARAAANALQQPLYRYLGGTDLELPQTFHNVINGGEHADNGIDIQEFMITPVERTSFRDGFEKIVNTYHTLKKVIEDAGYTSGLGDEGGFAPDLKNSEEALQMLHDAIIKAGYTPGKEIAIAFDAAASYFYNRTTHNYDFEGKTYTPAALGDYYLQLLAKFPEIVSIEDPYGEEDWDNFASFTAAHGDQLQIVADDPVCTNP... | 200 |
A0A9J7N2Y8 | 2.7.10.1 | ACT_SITE 757; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MSFGNVPGSALLLFLAGVSTLTVSSGEPRFTSVPGNIVATIGEDVVFYWDVTHEPEQTMLFIAYSTIDAGSIMYGRNDDFTVLPQYEGRVERVGQVGLRLRHVKASDSGTYKLHILFLNDVELENTASLDVRYPPTGTFIRVDLSQKTRKEENVNRFKVAAKKGTVLKLTCVTDSNPPAEFSWIKPTGDISAVNKTSGVLVIPNVRENDAGLYNCRARNGIQPDGIASINVTVQNPPTMTTTYIVSPRREIRKGDEVRIGCRVGDARPLPQFQWTRSDSKTEELPDTAVVDEETGLLTIASVKLEDAGVYRCVADNNVKP... | 97 |
Q86IZ3 | 2.3.2.23 | ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MAARLMKEYKVLQNEEFEDILLYPRDESDLYRWVAIIKGPPDTPYENGKFELDISVPTNYPLQPPTIKFVTKIFHPNIHFKTGEICLDLLKTSWSAIYTLQSVCRSIIALLSLPEADSPLNCDAGNLIRNGDVKGHDSLARMYTRLYGC | 64 |
P0A0I0 | 1.1.1.100 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10001" | MKMTKSALVTGASRGIGRSIALQLAEEGYNVAVNYAGSKEKAEAVVEEIKAKGVDSFAIQANVADADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANYVATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQDTDIANTVAFLASDKAKYITGQTIHVNGGMYM | 2 |
A0A9R1V9D1 | 3.1.1.11 | ACT_SITE 508; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASDGGKKKKVIAMAVLLVVGAVVSTIVTVRRHKDIEINVRKAGGKKTGIIAATAVTTAATTATVIILCKHTDFKKVCEETLSRVGLKEPRDLVKANFNAAMESILVAIEKSYTLQVAAKDPMAAKAIEQCNELLHVSIEDLKRSVDQVNIFDLPKLKQNIIDLRVWLSGAVTWQETCLDAFENTTGDSKMSMWKFMETGNRLTRNSLAILDGVAELSIDVQKSPRKVPKPRPKPLTMPISVNWKADLTINPMALRQDTGNGMNNNPADSQPATVGGDSKPMTGNRRMLDQLDDDFQDPVVHSNLQMVGDSSSKDDEIPT... | 125 |
A0A9R1W0I8 | 2.1.1.37 | ACT_SITE 658; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MEILKLKFYFYFIFIGVAPIYFPIWRFQYTKSPSHLSDSNSISHNTLLIFLSQWSQPEMVGNIDGNGGEGSTSTLHPPSRPPLSPLSPHPSSITAGTGDEGSSSHLPSKTPLSPLCPQSSSLPSSASQDTPAVRLATGGEDSTSHPPIKPPISLLFPEPSSVTANHDSPPVHFGTGGEGSNSRPPSKPPLSPSPQQPSSITANHDTPAVHSGQISRRRSPRLIDCNNGGTDSSFDFNNLPKKKKARTTEPFSSLPNNVSFLIGDPVPDEEARRRWPWRYDCGELKSKGRFPNSNNDNGNEDKLVLNVKCHYLQANIESHI... | 47 |
P42280 | 3.4.21.4 | ACT_SITE 87; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 134; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 234; /note="Charge relay system"; /evidence="ECO:0000250" | MSSSWIVGLLAFLVSLVALTQGLPLLEDLDEKSVPDGRIVGGYATDIAQVPYQISLRYKGITTPENPFRHRCGGSIFNETTIVTAAHCVIGTVASQYKVVAGTNFQTGSDGVITNVKEIVMHEGYYSGAAYNNDIAILFVDPPLPLNNFTIKAIKLALEQPIEGTVSKVSGWGTTSPGGYSSNQLLAVDVPIVSNELCDQDYEDFGDETYRITSAMLCAGKRGVGGADACQGDSGGPLAVRDELYGVVSWGNSCALPNYPGVYANVAYLRPWIDAVLAGL | 177 |
P20536 | 3.2.2.27 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10072" | MNSVTVSHAPYTITYHDDWEPVMSQLVEFYNEVASWLLRDETSPIPDKFFIQLKQPLRNKRVCVCGIDPYPKDGTGVPFESPNFTKKSIKEIASSISRLTGVIDYKGYNLNIIDGVIPWNYYLSCKLGETKSHAIYWDKISKLLLQHITKHVSVLYCLGKTDFSNIRAKLESPVTTIVGYHPAARDRQFEKDRSFEIINVLLELDNKVPINWAQGFIY | 173 |
C5XCY7 | 4.1.1.50 | ACT_SITE 80; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 94; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 245; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAMSSADSWGSSPTSPIGFEGYEKRLEITFSDAPVFEDPCGLGLRALSREQIDSFLDLARCTIVSQLSNKNFDSYVLSESSLFVYPHKVVLKTCGTTKLLLSIPRILELAAGLSLPVLSAKYSRGTFIFPGAQPAPHRSFSEEVSVLNGFFGNLKSGGNAYVIGDTFKPNKKWHVYYATEEPEHPMVTLEMCMTGLDAKKAAVFFKNSDDGSCTSAKEMTKLSGISEIIPEMEICDFEFDPCGYSMNGVFGPAASTIHVTPEEGFSYASYEAMNFNPSSLVYSDVIKRVLAGFSPSEFSVAVTIFGGRGFAKSWAKGADV... | 196 |
A0A804JUN7 | 3.1.1.11 | ACT_SITE 404; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAASSSLLHSLKKSRRKLLILLLSFLLLLALIATVTTLSSRRSSSVSTSHVILHTSCGATRYPSLCVSAISSSPSLLSSISSHRDVILASLNLTASAVHRSILHVHSLSSAYANLTDRERTALADCLDMFHVSLDELRRTANDLRVLPVAAKDHARPLPADPEILVSAAMTNQESCLDGFSHDQLDRRLRGSLIAELTHVMHMCSNALSMIKGLPGRGGVQRRKTTGFGVDKEGWPKWMGEEDRRRMAAEEVAADAVVAADGTGDYSTVGEAVAAAPSKSKKRYVIRIKAGTYAENVEVPKKKTNIMFVGDGRETTVITG... | 125 |
E0W1I1 | 2.7.11.1 | ACT_SITE 334; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSLLAYTNLLLQNGRIFRYYKKANIKKFIKKIIKLDLKSTPSEASVSRQTFLSTGLNSVKNAVQLQARKLLINNVLERVTPTLNSDLKKKAAKRLFYGDSAPFFALVGVSLASGSGLLTKDDELEGICWEIREAVSKGKWNDSESENVEQLQAANLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETVPAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLE... | 99 |
Q7XSK2 | 3.2.1.21 | ACT_SITE 196; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 410; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MAVAAATRIAVVVVVLALAVLAPAARGLRRDDFPPGFLFGAATSAYQIEGAYLDDNKGLNNWDVFTHTQAGRISDGRNGDVADDHYHRYTEDVDILHNLGVNSYRFSISWARILPRGRLGGVNSAGIAFYNRLINALLQKGIQPFVTLNHFDIPHELETRYGGWLGAAIREEFEYYSDVCFNAFGDRVRFWTTFNEPNLSTRHQYILGEFPPNHCSPPFGNCSSGDSRREPYAAAHNILLSHAAAVHNYKTNYQAKQGGSIGIVIAVKWYEPLTNSTEDVRAARRALAFEVDWFLDPIFFGDYPREMREILSSNLPKFTP... | 161 |
H2M2B1 | 2.7.10.2 | ACT_SITE 975; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MACILLTDMEPPNAQPPALQNGAPSDPDPTPAPDSKPEEEAICLSVQLYYVGKVGSGTKRSEDVLTFPAGEYVAEDLCIAAAKACGITPVYFSLFGLMRDSDRVWLPPNHMFKLHQSDKEKVLFRVRYYFSGWYNSSNSSCAHRYGFSKEMESPVMDDCVMAYLFSQWRNDFLNGWVHIPVSHEAQEECLGMAVLDMMRLAKENGQSPVDIYNDTSYKSFLPRSMRGRIQEYNLLTRKRIRFRFRRFIQQFGECKATICNLKLKYLMNLEMLLPSLYTERFQVHDLSSREVTIVVMGNKGILWSKGKEAEGADEELQAYC... | 98 |
A0A059CEV3 | 1.11.1.7 | ACT_SITE 52; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSMVVAAAAAQLQVHFYKDSCPQAELVVKGIMQQRFSADPSIPAGLLRMHFHDCFIRGCDGSVLIDSNGNRVAEKDAPPNLTLRGFEVIDQIKAELEKQCKGIVSCADILALATRDGVALTGGSAYALPTGRRDGTVSNISDVHIPGPSFSVAAAASAMQTINLSLEDLVTLLGAHAMGFCQCGFFVDRLYNFLGSGQADPNIDPQFLGVLRQKCPRPDPSVPFNLSTDPKIFMTPSSSTPFKLDTSFYRGVLNEQATLQLDQELAFTDLTRRMAADYISQPNAFRRKFAKAMIKLGNVNVLTGQQGEIRANCRKFNQPS... | 14 |
Q4V908 | 2.3.2.23 | ACT_SITE 95; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MNSNVENLPPQVLRLVYKEVSALAADPPEGIKIYPSEEDITELHTSIEGPEGTPYAGGVFRMRLVLGKDFPAVPPRGYFLTKIFHPNVGHKGEICVNVLKRDWKAELGLRHVLLTIKCLLIHPNPESALNEEAGKLLLEDYKEYASRAHLLTEIHAMGGTSGAPQEPADGPQPKKHAGDPNKRVVGAGLPTMGTGTNNSNISNTNIVAKKKTDKKRALRRL | 64 |
A0A5F8GHI5 | 2.7.10.1 | ACT_SITE 1042; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | GQPGSPSLSLKLTLPFSILPLPLGLVSTYSMTPPTLNITEEEYVIEAQDSLAITCRGQHPLEWAWPRRWEEPSQGDKESKVGVLAEVGAEQDCEGTDSRPYCKVLVLTRTQANDTGSYTCYYKYIKARIEGTTAVSTYVFVRDFEQPFINRLDTLLVNKDHTWVPCLVSIPDLNVTLHSQIRVIRPDGQEIVWDDRKGMLVPTSLLGDTLFLQCETIIRGRTFRSNFFIIHITGNELYDIQLYPKKALELLVGEKLVLNCTVWAEFNSGVTFQWDYPGKQTERAGAVTPERRSQQTHTELSSILVIQNVSQQDLGRYVCE... | 97 |
Q54IE8 | 2.7.11.1 | ACT_SITE 1034; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGKKKIDINTREDLFLSYYKEIEKNKFDLLKICSDKNFSKSNFLKAVHCLFSLSYFCKIKDENEEEEGKEEEINDYKVKKSTTGNYYRNSEGKLFKKSNEKDQIDDVSIFYKRLPTIQDFKDTYDKYENCLNSVYYIIRKIKLLHLEYFWEILASCYGTISFIKFFNIFSNEIFSPSENGDSVFIMVGKFFRRKVRAETHYDLIFLKIILANASIPMILKLGVKDIGRFTEKEDIIVSYYRNFSIIHSLRFDNVKEFALVYKTLKNNYPSKKKKKITLFEENGKINVKTSKKDLMLFEFVCKFDCVKIFKKYFLPKPQII... | 99 |
A0A9R1WMA0 | 2.7.1.11 | ACT_SITE 232; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MSSSAMNPPIQDQLQTLTISPLTVTLKRLPHITDDLPNLQTQTNPLQSNSFYHPCDDGFYISHSDVILRQIVFDFSGNFPSSSPHLAYHRAGPRKEIFFDPKQVCAAIVTCGGLCPGLNTVIRELVVGLWELYGVREIFGIKAGYRGFYSGDLIRLDPKLVHNWHKRGGTVLETSRGGFDLQKIVDAIQNRRFNQVYIIGGDGTLRGAVKIFNEIQRRKLNVAVVGIPKTVDNDVGIIDRSFGFQTAVEMAQEAISAAHVEAESAPNGIGLVKLMGRHSGHIALDATLSSCDVDCCLIPENKFYLEGKGGLFEFLGIRLK... | 84 |
Q8RXK7 | 3.1.1.11 | ACT_SITE 389; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 410; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MLSLKLFLVTLFLSLQTLFIASQTLLPSNSSSTICKTTPDPKFCKSVFPQTSQGDVREYGRFSLRKSLTQSRKFTRTIDRYLKRNNALLSQSAVGALQDCRYLASLTTDYLITSFETVNITTSSKTLSFSKADEIQTLLSAALTNEQTCLDGINTAASSSWTIRNGVALPLINDTKLFSVSLALFTKGWVPKKKKQVASYSWAHPKNTHSHTKPFRHFRNGALPLKMTEHTRAVYESLSRRKLADDDNDVNTVLVSDIVTVNQNGTGNFTTITEAVNSAPNKTDGTAGYFVIYVTSGVYEENVVIAKNKRYLMMIGDGIN... | 125 |
Q0UGT7 | 1.1.1.37 | ACT_SITE 179; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MVKAVVAGAAGGIGQPLSLLLKSCQLVTELALYDVVNSPGVATDLSHISSPATVTGYLPKDDGLQGALTGADIVVIPAGIPRKPGMTRDDLFKINAGIVKGLIEGIVKYCPKAFILVISNPVNSTVPIAAEVLKAAGVFDPKKLFGVTTLDVVRAETFVAEITGEKNPAKLNIPVIGGHSGETIVPLFSQAKPSVNIPADKLDALVNRVQFGGDEVVKAKDGAGSATLSMAYAGYRFAEKVIKASQGEKGIVEPSFVYLPGVAGGDAIAKATGTEFFSVPIELGVTVRRRRLTSSAAPTNTRRSCSRLATMASRATSPRV... | 5 |
P07527 | 2.7.10.2 | ACT_SITE 693; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSSSNTSSHRSYGLRRSQRSMNLNRATLLAPPTPSSLYDANNSTSSTSSQKPNTSFTSLFGPRKQTTSSPSFSHAAPLHPLSPPSFTHSQPQIQAQPVPRRPSLFDRPNLVSRSSSRLGDSPSLSPVAQVANPIHHTAPSPSDVRAFPIHKNASTGVKRSFFSSSMSNGAMSPPSHSPSPFLQSSQHIPPSTPAQKLRKKNNFDSFRISNSHISPFASGSFSPFATSSPNFLSTSTPAPPNSNNANPSTLFSSIPSSRHTTSNHFPSNSAQSSLFSPTARPLTARKLGFASSQTKSAVSNNHSRNSSKDASFMMKSFIP... | 98 |
Q22922 | 3.5.4.5 | ACT_SITE 64; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MTTTKANLTEFEQQLVDKAIGAMENAYCKYSNFKVGAALVCDDGEIIIGANHENASYGATICAERSAIVTALTKGHRKFKYIVVATELEAPCSPCGVCRQVLIEFGDYKVILGSSTSDQIIETTTYELLPYAFTPKSLDDHEKETEERKHHNDHNNKE | 187 |
Q8F4A2 | 1.1.1.37 | ACT_SITE 187; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01517" | MSKTVKVAVTGAAGQIGYSLLFRIASGQMFGADTAVEIQMLELEAAIPAAKGVIMELEDCAFPLLQKVTVSSDLDTAFKEINWALLVGSVPRKAGMERGDLLKINGGIFVNQGKAIEKNAASDVRILVVGNPCNTNCLIAMNNAKGISQDRWFAMTKLDENRAKSQLASKAGVPVKEVTHLGIWGNHSATQYPDFYNTKISGKPVTDVISDHEWLKGDFIKNVQQRGAEIIKARGASSAASAANGVVDTVRGIITPTAPGDCFSAAVVSDGSYGAEKGLIFGFPLKSDGKKVEIIQGISLNDFAKEKFKITHEELVSERN... | 5 |
M4CA55 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKIAKFSVLLLILYIFPVAFSQLRVGFYSQSCPNAEIIVQNLVRERFGLDPSITAALTRMHFHDCFVQGCDASLLIDPTTTQPSPEKNAGPNGSVRGYELIDEIKTALEAQCPSKVSCSDIVTLATRDSVFFGGGPSYVVPTGRRDGFVSNSEDAEGILPGPGLPVPDMLTFFGNKGMDVFDAVALLGAHTVGIGSCGNFVDRLTNFQGTGQPDPTMDPGLAGRLRNTCSAGGSQFAALDQSTPFAPFSFDNLFYTQIRERKGVLLLDHLLATHPSTSGVVFQYAANNELFKRQFAIAMVKMGSVDVLTGFAGEIRRNCR... | 14 |
E9FX74 | 2.3.1.48 | ACT_SITE 167; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MGRFEMEVWYQSPYPDDLARLPKLYLCEFCLVYMRSRTVLRRHAAKCVWRHPPGDEIYRKEKVSVWEVDGQEKKTYCQNLCLLAKCFLDTKTLYYDVEPFLFYVMTVADSEGCHSVGYFSKEKNSFLNYNVSCIMTLPPYQRQGYGRLLIDFSYLLTRTEGKVGSPEKPLSDLGLISYRSYWKDVLLEHVCSYPGKEISIKDLSQEMAINAYDIVSTLQALGMMKYWKGKHIVLKKRDVIEEYQERAKRRGPEWRHTDAKYLRWRPFVVPQETPP | 61 |
O04953 | 3.1.1.11 | ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 144; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MPCLFIFIALLLSSCIGTLKALDQTCGNKVVNTIVVDQAGSGEGQRVTTITYNGHAATDVSSTFTSYPSHIVVRNLSIMNTYNRLTSLTKANGMSWDIKPAVAISVYGDKSAFYNCDFLGLQDTVWDNLGRHHFKNCYIEGAIDFIFGSGQSVYEDCHINATAGALASKVSFGYITAQGRSSDSDPSGFVFLRGSVSGSTSVYLGRAYGPFSRVIFIQTDLSSVVHPEGWYSWHYGGYEMSFTYAEVECKGAGSDMSRRVPWIDKLHSFYTKQQFSISNFIDQDQWISNIPRF | 125 |
Q8AXB3 | 2.7.10.1 | ACT_SITE 1003; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MTPLKTSVKAFFTLHVLFSCISHGLVEGSRLPDPQLLPDGDTHLQHVGGTLTLICRGSTALHWRLASRNVSSVRIESCEERLHKHCSKLVIHNLRHNDTGIYSCSHKKSSDHEVSTYVFVKDPHHPFVEAYSLPHPLFAYRNDPYFVVPCRTTYPNQNVILETQMNPMADDVKRGVQWDPKKGFTVPLKPYDSYHLITCLTRVDNAEFSSVYLLKRLTMEIKNLAIEPERPRVLVGDTLILNCSAETTYNGRIHFEWEFHKERINRTHHFSTTPVQLAQIMVMSKALIVPNVTMEDKGTYTCTGSIEFKKLQMSTKVIVY... | 97 |
G3XD54 | 2.7.7.7 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR606309-1" | MRSVVLDTETTGMPVTDGHRIIEIGCVELEGRRLTGRHFHVYLQPDREVDEGAIAVHGITNEYLKDKPRFREVANDFFEFIRGAQLIIHNAAFDIGFINNEFALLGQQDRSDVTEYCSVLDTLLMARERHPGQRNNLDALCKRYGVDNSGRDLHGALLDAEILADVYLAMTGGQTSLSLAGSGAEGDGSGRPMVSPIRRLDPARVATPVLRANAEELAAHAARLAVIEKSAGGPSLWAQLEAPVGE | 121 |
Q9VEG6 | 1.11.1.7 | ACT_SITE 320; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P05164, ECO:0000255|PROSITE-ProRule:PRU00298" | MSRILFILLLLIVTQLSELQAAAFSVRQNRFDEVPDLQTPAPLATSTESSKKPEKATSGLLKKCLPCSDGIRCVPQIQCPAHVRMESHEKPQICDLPAGKFGYCCETGQNHTAPKPETSPKERRSGFPTILSPAVLDEARRNFEHLMHGVAQIPVRRGFPDFAHGLVFHSTAKDDLHNFAISNSAIEQVMTTQLFGKKEQVPVEDFITNNVPIKFTETPLAHHCQPPPVCGNIRSVYRSMDGTCNNPEPQRSLWGAAGQPMERMLPPAYEDGIWTPRAHSSDGTPLLGARKISRTLLSDVDRPHPKYNLMVMQFGQVLAH... | 14 |
Q7SCT1 | 2.7.11.1 | ACT_SITE 272; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MDNRTGSRVSVRQPLGDATNRANIAAMQTSSRPKLEANAKSWKNTNRSKSNPPIITDIPLVQHHIVTIPSPVAVPDVPSMSRLRHPSSLQQMNTQASDARRVSQFSNVSSNASITRLQKTHIGPWQLGKTLGKGASARVRLARHRTTHQLVAIKIVAKSTAHVTQATSMANLDRVDYRKPSISTDGVRRMPLAIEREVAILKLIQHPNIIKLHDIWENRQDIYLVTEYVEKGDLFDFINWNGSLNEEEAIFYYRQIMSALEYCHSFNICHRDLKPENILLKADGQIKIADFGMAALHQEPTHHLKTACGSPHYAAPELLK... | 99 |
Q9UNA4 | 2.7.7.7 | ACT_SITE 152; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00216" | MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVIL... | 121 |
P9WN91 | 1.3.5.1 | ACT_SITE 232; /evidence="ECO:0000250|UniProtKB:P00363"; ACT_SITE 248; /evidence="ECO:0000250|UniProtKB:P00363" | MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHTVSAEGGAAAVTGDDDSLDEHAHDTVSGGDWLCDQDAVEAFVAEAPKELVQLEHWGCPWSRKPDGRVAVRPFGGMKKLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTLLVDDGRVCGLVAIELATGRIETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAPLKDMEFVQYHPTGLPFTGILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSMELGPRDRLSQAFVHEHNKGRTVDTPYGPVVYLDLRHLGAD... | 28 |
P54548 | 3.1.26.11 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01818, ECO:0000305|PubMed:15654328" | MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQHQILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIETSLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKADVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKLKELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQGDASLELQKEAVDVFPNSVAAYDFLEVNVPRG | 137 |
B6JXE7 | 2.3.1.286 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MDSQAVENEKILKNVADDIKNGKYKNICVMVGAGISTAAGIPDFRSPKTGIYHNLQKFNLPYAEAIFDLEYFRENPKPFFELAYELMPGRYMPTPTHYFLRLMNEKGLMLRCFTQNIDTLERIAGVPEDKIVEAHGSFQYNRCIECKEMADSGYVRHCIETKDVPLCEKCKGYVKPTIVFYGEGLPSRFFDCMYEDMEKCDLALVIGTSLLVHPFADLPEIATENCQRLLINREVVGDFSERESDLMVLGDCDALVRQLCKYLDWEKDLDELVKANNEVDLLADVMSNVTLEPKLKGTNVEEDTEDEKEGVTGALPGTIS... | 58 |
M0RDA4 | 2.7.10.1 | ACT_SITE 749; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MELRALLCWASLATALEETLLNTKLETADLKWVTYPQAEGQWEELSGLDEEQHSVRTYEVCDMKRPGGQAHWLRTGWVPRRGAVHVYATIRFTMMECLSLPRASRSCKETFTVFYYESEADTATAHTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNIKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCSRLVTNLTYFPETVPRELVVPVAGSCVANAVPTASPSPSLYCREDGQWAEQQVTGCSCAPGYEAAEGNKVCRACGQGTFKPQIGEEPCLPCPANSHSNNIGSPVCLCRIGYYRARSDPRSSPC... | 97 |
F6HQV0 | 2.3.2.26 | ACT_SITE 1491; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MGNRGQKRPESVEELPADKRACSSLEFRPSSSSNSPGQTHTNSPNLAPESQDGGHDGGEMDTSSSASGSVRSEEAEKDSAYGSCDSDDLADGELRFNRDILRDFQRRRSSGDQAKFKKILVTLTEADEVDVSGVLAALTELCEVLSFCTESSLSSLTVDSLAPVLVKHAKHESNPDIMLLAIRAITYLCDVFPRSSGLLSRHGVVPALCERLMAIEYLDVAEQCLQALEKISRDQPLACLQSGAIMAVLNYIDFFSTTVQRVALSTVVNICKKLPSECTAPFMLAVPSLCNLLQYEDRQGLIGSLVKLASGSVVAVRTLF... | 65 |
A8X0C4 | 2.7.11.1 | ACT_SITE 324; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEGPSSSSVPTASDAPSKYLLPSDSDDGIATSSAANVGARNHVTNTEKMEKEKKPSPMVLNVDPDYDYDEEDGGSCEEDQRGPPAPISREIVDGAIARRSRDRQISPGVKMSIGNYDDMEDDDEEAETPEEQKQRFLASMKRIRNQPQEAFDPPEDTEAMREFINRQVNDAMMFNRDNHIDYSPVNKPKEAKIIEGYLWGGIIGTGSYGKVKEVIDIYTITRRAAKIMKYEKLRKIPNGWDNIRSEMSILRRLNHRNIVKLIEVFNLPEKGKVYMIFEYCIGSVQNLIDMEPAHRLSIGESHAIFLELCHGLNYLHSKRV... | 99 |
A0A1S4BP33 | 3.1.1.11 | ACT_SITE 416; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MALPNENDQESVAARKKTIKRISIIAISSIVLVGCIVAAVVGITLGKNDGNSGNQSKSFSTAIKAICDITLYPQSCYSSLGPLAKSNNLKPQDIYKLSVQVATDELSRASDDFFNMPELKNISDPMAVKALESCHELISLSLDSLNESLSIPNKSFSEAFSDLKTRLSAAGTYQQTCIEGFGNVTYAFASIASHNFKNSGEYTSNSLAIIDNIDQSIQNSIDSMDSLGGIGRRRRLMNFDGDFPSWMGSNDRKLLQSSKGKNSTKVDVVVAKDGSGDFITITKALQAVPEKSNKRFVIYVKKGVYVENVRVEKKKWNVMM... | 125 |
Q54DU9 | 3.1.3.48 | ACT_SITE 75; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 107; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MTGIRSALPNPASLVESSTHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVAIALIEGGMNPLQAVEYIRERRRGSINIKQIQYLKNYKSKKKSSCRIM | 149 |
Q84M95 | 2.7.11.1 | ACT_SITE 205; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MHFPLVSAWNKRRRSKSYDTDPCTFLFSIIFARWHKRVYRTAECWQIEDQASQPRKRRFGSSVYTLKEMEEATSSFSDENLLGKGGFGRVYQGTLKTGEVVAIKKMDLPTFKKADGEREFRVEVDILSRLDHPNLVSLIGYCADGKHRFLVYEYMQNGNLQDHLNGIKEAKISWPIRLRIALGAAKGLAYLHSSSSVGIPIVHRDFKSTNVLLDSNYNAKISDFGLAKLMPEGKDTCVTARVLGTFGYFDPEYTSTGKLTLQSDIYAFGVVLLELLTGRRAVDLTQGPNEQNLVLQVRNILNDRKKLRKVIDVELPRNSY... | 99 |
Q9VE30 | 3.1.3.2 | ACT_SITE 10; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 126; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1" | MTFKKILFVCMGNSCSSPMAEVIMQNLMVKTSLYWEVDSAGLRTWNTGRRPNKRCLQILREHGLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKELLLWAADNRAGKHCQVLLLSSFGKNGLPAFIDSLSPTHKLKNFRSAYYQIKECCKQLILSQKVDIVKYELPSTDDDELYYSGKDNAPQDSAKANHLTETSHNNSGIYLLNTEIRSSGGLMSSSTDPSNSKTSMPSCSQGVQRKLCQKCGQKFLAAL | 145 |
Q6C482 | 6.3.4.4 | ACT_SITE 12; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 40; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125" | MADVVLGSQWGDEGKGKLVDILCDQIDVCARCQGGNNAGHTIVVGDVKYDFHMLPSGLVNPNCQNLLGSGVVIHVPSFFDELKAIEDKGLNCRDRLFVSSRCHLVFDFHQLTDGLKEQELSTTKKAIGTTGKGIGPTYSTKASRSGIRVHHLVSQEPGAWEEFESRLRRLVGTRQKRYGDFDYDVEEEIKRYKKLADDLRPFVIDAVPFMHKAIKANKRILIEGANALMLDLDFGTYPYVTSSNTGIGGVCTGLGIPPTAIRNIYGVVKAYTTRVGAGPFPTEQLNNVGEHLQEVGAEFGVTTGRRRRCGWLDLVVLQYS... | 253 |
Q06551 | 2.3.1.225 | ACT_SITE 203; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250|UniProtKB:Q8VDZ4" | MALVSRRSTRSESTSITKEEHTGEGSLTKLFFRWLVTLEGDQDINDGKGYISLPNVSNYIFFLGGRFRTVKGAKPLWLGVLLAIVCPMVLFSIFEAHKLWHTQNGYKVLVIFFYYFWVITLASFIRTATSDPGVLPRNIHLSQLRNNYQIPQEYYNLITLPTHSSISKDITIKYCPSCRIWRPPRSSHCSTCNVCVMVHDHHCIWVNNCIGKRNYRFFLIFLLGAILSSVILLTNCAIHIARESGGPRDCPVAILLLCYAGLTLWYPAILFTYHIFMAGNQQTTREFLKGIGSKKNPVFHRVVKEENIYNKGSFLKNMGH... | 57 |
Q8QFP9 | 2.7.10.1 | ACT_SITE 640; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MVYPGPPGLIAGLLLAALSLSCVDGAKALGFVGHGYNLTVSQGHEAKLNCSLQGIEEPEIQWLKDGVPVQSADQMYIPVDEDHWISFLSLKNVERPDAGKYWCEAEHSGRKSVSDAIWIMVEGVPYFTLEPKDLSVTPNSPFNMTCAAVGPPEPLVIIWWVGDSPLGKSESSPSVLQMSGIHERTAFSCEAHNAKGVSSSRTAIVEVKGLPYPPFNVTISKVTGSTATVTWFPGFNSFSLIKSCTIQVQSLHGNREMYSRLISAPPFAVLLDELQPLTNHSVRVQCTNEMGASPFTEWRTFHTKETVPQLLPQNVHMTKT... | 97 |
T1EFA0 | 2.3.2.26 | ACT_SITE 1992; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MIPIYMKKLLPIFIHTFQSSMWLPVRKASLTLIKKIIGYIEASLLEEIVKPDSTSSNSNISVQLSEILSTVLNAEEEEESHYVVLQIIQELLKKYPSAFMDQFVQLGIFNRIQNMAGGEGNEDEKIASHAFSDHNSHVEMVMFRPYTWKSWCLVRGRDCIYLWSEYAALELSNGSNGWFRYILENKLSTMYSSGSPEGGTDSSENRGEFLEKLQKVRNQVKASIPVQSIFATTDASALVVGNWTFVCKNDNELHIQNSDGQQTTILKEDQTGFIFESNRGTKHPFISAISLGPEFASGWAGHKSKKFFSKTEEIKQKVKT... | 65 |
A0A2K1JZU6 | 1.11.1.7 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MESRHNLLQRRPTLWTAVVLVILQLALSCWMCTVDALQTGYYAATCPNAEAIIRAAMERGMQEDSGTAPGVLRLHFHDCFVDGCDGSVLLDGPRSEKTASPNLTLRGYEVIDAAKADLELACSGIVSCADILAYAARDAVVLTGGLGWAVEAGRLDGRVSDAGRAFAEIPDPSFSSAQLAAVFARKGLTTSDMIVLSGAHSIGRAHCDSVKTRLYPVQDPNLREPLAAELRSGCPQQGGSATFSLDSTPNQFDNAYYIDVVNGRGIMRSDQALFDDPSTRTETMFNSLGAAPWAFRFGQIMVKMGQVGVKTGPDGEIRRN... | 14 |
P0A7F6 | 4.1.1.50 | ACT_SITE 112; /note="Schiff-base intermediate with substrate; via pyruvic acid"; ACT_SITE 117; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000250"; ACT_SITE 140; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000250" | MKKLKLHGFNNLTKSLSFCIYDICYAKTAEERDGYIAYIDELYNANRLTEILSETCSIIGANILNIARQDYEPQGASVTILVSEEPVDPKLIDKTEHPGPLPETVVAHLDKSHICVHTYPESHPEGGLCTFRADIEVSTCGVISPLKALNYLIHQLESDIVTIDYRVRGFTRDINGMKHFIDHEINSIQNFMSDDMKALYDMVDVNVYQENIFHTKMLLKEFDLKHYMFHTKPEDLTDSERQEITAALWKEMREIYYGRNMPAV | 196 |
P46573 | 2.7.11.1 | ACT_SITE 204; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGICLSAQIKAVSPGASPKYMSSEANDSLGSKSSSVSIRTNPRTEGEILQSPNLKSFTFAELKAATRNFRPDSVLGEGGFGSVFKGWIDEQTLTASKPGTGVVIAVKKLNQDGWQGHQEWLAEVNYLGQFSHPNLVKLIGYCLEDEHRLLVYEFMPRGSLENHLFRRGSYFQPLSWTLRLKVALGAAKGLAFLHNAETSVIYRDFKTSNILLDSEYNAKLSDFGLAKDGPTGDKSHVSTRIMGTYGYAAPEYLATGHLTTKSDVYSYGVVLLEVLSGRRAVDKNRPPGEQKLVEWARPLLANKRKLFRVIDNRLQDQYSM... | 99 |
Q8RX86 | 3.2.1.22 | ACT_SITE 161; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P17050"; ACT_SITE 216; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P17050" | MVLLSFSLRFIAFTLTITLTQIADGFQSRMLMNNGLALSPQMGWNSWNHFQCNINETLIKQTADAMVSSGLSAIGYKYINIDDCWGELKRDSQGSLVAKASTFPSGIKALSDYVHSKGLKLGIYSDAGTLTCSQTMPGSLGHEEQDAKTFASWGIDYLKYDNCENTGTSPRERYPKMSKALLNSGRSIFFSLCEWGQEDPATWAGDIGNSWRTTGDIQDNWKSMTLIADQNDRWASYARPGSWNDPDMLEVGNGGMTKEEYMSHFSIWALAKAPLLIGCDLRSMDKVTFELLSNKEVIAVNQDKLGIQGKKVKKEGDLEV... | 162 |
O60566 | 2.7.11.1 | ACT_SITE 882; /note="Proton acceptor"; /evidence="ECO:0000250" | MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLE... | 99 |
D2CFZ3 | 1.1.1.205 | ACT_SITE 326; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 427; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MADSNSLLEDGQSLQDMMNDGVGLTYNDFIILPGYIDFTPDAVDLTTQLTKKITLKSPLVSSPMDTVTESSMAIAMALCGGIGVIHHNCSPSYQANEVLKVKKYKHGFIHNPVVLCPTNTVADVLKTKKEQGFSGIPITEDGKMGGKLVGIVTSRDLDFLEDQNYSNSKLETIMTKLEDLVTAQSGVTLPEANSILAKSKKGKLPIVNAEGNLVALMARTDLKKAKSYPTASKDDNKQLIVGAAIGTRDEDKERLKLLVNAGVDVIVLDSSQGNSVYQIEMIKYIKKSYPSLQVIAGNVVTAKQAKNLIDAGADALRCGM... | 3 |
Q83BK4 | 3.4.21.89 | ACT_SITE 71; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 126; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MIVDFAFYLTVAVILTGVISFIDKLFLKKRRSPKAKASLSIEYAKTFFPVLLIVWVVRSFIIQPYHVPTGSLEPTVMPGDFIAVEQFAYGLRLPVLNKKILPISEPKRGQIALFRWPKDPKIVFVKRVIGLPGDHIVYKNKRLYINGQEQKQNFLYKTNDVSSWGYRRIVNVKEENLDGVKHKIYVQPAGGETEDYNLVVPPRHYFMMGDNRDNSDDSRQWGFVPEKDLIGKAFGIWMSWDKLLNRIRWDRIGNAL | 178 |
A0A2I2UKY7 | 3.5.4.5 | ACT_SITE 67; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MAQERPACALEPELVQRLLLSCREAKKSAYCPYSHFPVGAALLTRDGRIFSGCNIENVCYPMGICAERTAIQKAISEGHREFRAIAISSDLQDDFISPCGACRQVMREFGTNWAVYMTKPDGTYVVRTVLELLPSPFGSLGPQKIQ | 187 |
F6VUC2 | 2.7.11.25 | ACT_SITE 268; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAAGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFTMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEV... | 105 |
Q756Z0 | 3.1.1.5 | ACT_SITE 1252; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1370; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MVDGTYVNSSVEAISGEADTAAVAELANQMVMNFLYESSSWLAQSTGPFLWKGFRFLFLRLPSSLLVYLINGTVPFYLVVLGSVFTPIIVYLILRSRVLSAYSRLKGDNEDEVIDKKKQLVNDSEAMLMGGPDGKRRSGFSSYLDEFLSAIKIFGYLDKLVFHELTKSMRTQRLEQGEVMLLDDSVGFAIVVEGGLHIYHKIAHSQGSTRESMPLPEDRSFDSNEDDLTINGERFQLLNKVKAGNPVSSLVSILKLFTDNHTPTVVDSSKSSPKQSAQVPIRQLISPFLDGNVERNKATLNMKQVPTAEYEIPSAERAGS... | 131 |
A0A022QCW0 | 3.1.1.11 | ACT_SITE 372; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAAAASFFKCMLLVLPLCLLLPCGNSDFFGETTAYLNVPAAKFERAVESTAAQLRQVISTISKFSAETSGGDLRLSNALSNCYDLLDFSLDLLNSTTQLVTSRNPSRKDRSSNEKYGSFEMMKNVKCPLTVNPETCKEGFDAIPDNNPVKNSIFSQLDSVATSAQKLSAMVNPNYLTTTQSKIRRGRKLIGDHDHAQFPDWVKPHDRKLILEGAAASITGVDAVVAADGTGDFTTIMAAIEKAPKNSTRRYVIHVKKGVYREYVDISKHKWNIMMFGDGIDATIISGNRSKTDELSTYRSATFGVKGRGFVAMDMTFEN... | 125 |
C5Z0E4 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MWRERRPPPPLLLIVAGAALLVIGAALASAPPEAALKVGFYHETCPIAEDVVLAEMRLILMEDATVAPALLRMHYHDCFVQGCDGSIMLRSRKKGKAERDAVPNRSMRGYDAVERIKARVETVCPLTVSCADIIAMAARDAVYLSHGPWYDVETGRRDGNVTVAEYVENDLPPPDSNIVDVKTFFSVKSLNSKDIAVLFGCHSIGTSHCGAIQKRLYNFTGNMDQDPSLDPAYAAELRKLCPPPRPGGDDDGAGGEGKVKVPLDPGSNYTFDLSYYRHVLATGGLFQSDGSLLHDPVTKGYVEKVAKAASPDEYYADFAA... | 14 |
A0A1L8FRF1 | 2.3.1.48 | ACT_SITE 554; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR003048-1" | MSEAASGGGTMVCVAASGCSALPQGSPAVVASAASGAARGAESPAAAAGGGGGGSAPLRIAAKNGQLRSAPRAKKLEKLGVYSACKADETCKCNGWKNPNPPPTPPRMDLQQTVISLTEPCRSCGHTLAAHVSHLENVSEEEMNRLLGIVLDIEYLFTCVHKEEDADTKQVYFYLFKLLRKCILQMVKPAVEGSLGSPPFEKPSIEQGVNNFVQYKFSHLPSKERHTIIELAKMFLNHINYWHLETPSQGRLRSPNDDIPAYKENYTRWLCYCNVPQFCDSLNRYETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPQ... | 61 |
A0A804KK34 | 3.2.1.14 | ACT_SITE 109; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MASLRSRNSWPLALPSFFYLLASSLLSCTAQSAEAGCGPYGHGVSSIVSEELYHSIFLHKDDSACPANGFYTYASFVRAASSFPRFGRTGDLDTRKREVAAFLAQISHETTGGWATAPDGPYAWGLCFKEEINPQSNYCDSTNKKWPCYPGKSYHGRGPIQLSWNYNYGPAGKALGFDGLKNPETVANNSEIAFKTAIWFWMTEQKPKPSCHDVMVGRYRPTAADVQANRTIGFGLVTNIINGGLECGVPGDSRVADRIGFYKRYAQLFDVAVGPNLDCAYQKPF | 158 |
Q9K0D4 | 4.2.1.20 | ACT_SITE 47; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 58; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MSRIRQAFAALDGGKALIAYITVGDPDIRTTLALMHGMVANGADILELGVPFSDPMADGPVIQRAAERALANGISLRDVLDVVRKFRETDTQTPVVLMGYLNPVHKMGYREFAQEAAKAGVDGVLTVDSPVETIDPLYRELKDNGVDCIFLIAPTTTEDRIKTIAELAGGFVYYVSLKGVTGAASLDTDEVSRKIEYLHQYIDIPIGVGFGISNAESARKIGRVADAVIVGSRIVKEIENNTGNEAAAVGALVKELKDAVR | 202 |
G7IYH9 | 3.1.1.11 | ACT_SITE 364; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAIIGKTLFMLFFLSSIFSIASSRKGPSSSNIDWWCNLTPHPKPCKHYTTQMNNHFKIKHRVEFREMLVQLALKQALTMQKEAQENSQQQQNSFVHKTVHGDCLKLFENTIFHLNRTLEGLNNASKNCSPNDAQTWLTTSLTNIETCKSGALELNAQDFDFIMQTNVTEMIRNILAINMHFLKHSKETEEGSFPNWFSVHERKLLQSKGPVKYNLVVAKDGSGQYKTVQAALNAAAKRKYKTRFVIHVKKGVYRENIEVAVHNDNIMLVGDGMQNTIITSSRSVQGGFTTYSSATAGIDGLHFIARDITFQNTAGPHKGQ... | 125 |
Q9FJ54 | 2.7.11.1 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDKNGIVLMRKYELGRLLGQGTFAKVYHARNIKTGESVAIKVIDKQKVAKVGLIDQIKREISVMRLVRHPHVVFLHEVMASKTKIYFAMEYVKGGELFDKVSKGKLKENIARKYFQQLIGAIDYCHSRGVYHRDLKPENLLLDENGDLKISDFGLSALRESKQQDGLLHTTCGTPAYVAPEVIGKKGYDGAKADVWSCGVVLYVLLAGFLPFHEQNLVEMYRKITKGEFKCPNWFPPEVKKLLSRILDPNPNSRIKIEKIMENSWFQKGFKKIETPKSPESHQIDSLISDVHAAFSVKPMSYNAFDLISSLSQGFDLSGL... | 99 |
H2LRN7 | 3.2.1.143 | ACT_SITE 510; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 528; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 529; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MMDSQKSVDPDDLSRERNDVLLQADRKDELFSVPQMTDITNDHISQENPQDGFVSQSLIDTASADEAEEPRLEDCRGAGAQTFDSNGQKSKRSSSPGPQPVKATCVAESQPLTLHLSSKIVESTPNDVEMLSPESPVCKTLNISSSLDEEEDAKMLAENPVLELELHMNDPGNAATEKVNLPAFGSEGADKAENSDSSLTQHLLDRQSNEVCKSDSSTSFLHNTEKNFRGTPIDELNRLPQCAPPLSRLKANPGHTVTIRTDLLREGKVPIPYPSKFQDSWDDAHVKMPCSEKNMFPIETEDGSGLQSRWDLIHSSLRRG... | 159 |
B7Q8W6 | 1.11.1.24 | ACT_SITE 75; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MGARQVVLQCAGRQFGFLSFLRKVREMALPKLTHPAPDFSGTAVVGGQFKDIKLSDYKGKYLVLFFYPLDFTFVCPTEIIAFSDHVEEFRKINCEVVACSTDSHFCHLAWINTSRKEGGLGNMNIPLLADKTCKISRDYGVLKEDEGIPFRGLFIIDDKGRLRQMTINDLPVGRSVDETLRLVQAFQYTDKHGEVCPANWKPGGDTMKPDPKGSKDYFSKH | 12 |
B9N564 | 3.4.19.12 | ACT_SITE 318; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 767; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MDLLRSNLSRVRIPEPTNRIYKQECCVSFETPRSEGGLFVDMTTFLAFGKDYVGWNYEKTGNPVYLHIKQTRKVVPEDRPLKKPTLLAIGVEGGFDNNEPEHEENHNIVILPDYVTLPFPSVELPEKVRLAVDAIIMAEGAERKEQLAAWIAADKKQVSAYAMSLPQIDNGVVIPPSRWKCAKCDKKDNLWLNLTDGMILCGRKNWDGTGGNNHAIEHYKETSYPLAVKLGTITADLEAADVFSYPEDDSVVDPLLAQHLAFFGIDFSALQKTEMTTAERELDQNTNYDWNRIQESGQDVEPIFGPGYTGLVNLGNSCYM... | 175 |
A0A0K9NRS0 | 2.3.1.181 | ACT_SITE 180; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MSLKRGLDVWKLGKVNYSEGLKLQAKLCSRRKSGEIPDTLLSLQHPPTYTVGKRRTYHNLLIPESQLKSIGAELHHTERGGDITFHGPRQIVLYPIISLKDIHFGARRYVETLEAAMVELAGAYGVEAHVGGSKCDTGVWIGDKKIGSIGVRISSGVTSHGLAFNVGSDVLDYFKNIIPCGIAGKGVTCLSREVSPRHLPLPPDGIIHDQLISRLSRLLGYNQITCREDINIAQ | 55 |
A0A8V0YFC8 | 3.1.3.48 | ACT_SITE 786; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1"; ACT_SITE 1102; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002004-1" | MFLCLKLLAFGVAFLCQDAFAQAGNDNLTSASSLSSTLPTPTRSTSFSPPSTTAGVQPASTGASPTASTHLSTHSGSGPTTGLGHLQHSSPAALTTRTLTAFHQTVSDYYSSTSLHNTTSPVITPASTETIPTSTIESTTTTEEPCDNSIDYGNIEEKNNSAEVTLKNLKENRIYDILLEDGKSLSVNASNNIVMLNWCRRYTVQSRNCIVMYLTIPPDEKRYTFDVESIGNDNATLRLNPLCIDCEDVCSNVTVSCKTNSINSGGTGNLTGSYELMKHDINADNITILSLSSDSEYLCRVTVRFFEKNFTKEVNITTDY... | 149 |
A0A251QM44 | 3.1.1.11 | ACT_SITE 218; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAGKMMHAAGFIIITILLAGSTPAVANDSTPIPADGSQVGSWFDNNVKPLTERKGTLDAAIVTAEDGPKLIKVMKDGSGNFKTLTEAINSIPERNTKRVVVYIGGGVYNEKIKIPQNKPFVTLYGSPNNMPNLTFDGTAQKYGTVYSGTLIVESDYFRAANIIVTPDGIRPDAQAVALQISGDKASFYNCKFFGFQDTLYDYKGLHFFKDCYIQGTVDFIFGKGKSLYLSASEDNEFSFVHCKITGTTYVRGTYLGRAWGSSPTVVFAYTDMADVVHPERWSDFGHPERSK | 125 |
Q0UWV5 | 2.5.1.18 | ACT_SITE 27; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MNNNPINRNPLTKMAQPKITLYVDIVSPFAYIAFYILKNSPVFKQCEITYVPIFLGGLMKACGNTPPLHIKNKDKWIDAERLRLCKYFNVPMSQNTPPGFPINTIAIQRALASLEISHPQSMPQAIGLFWENFWVQYNDPMKPENLSAIVRTIVGSEEGAKKVLESTKGEEVKKRLSENTDKALKGGAFGLPWFEATNAKGETEGFWGVDHMGQMCDHLGLERPSGKGWKALL | 77 |
K7VXP1 | 3.2.1.14 | ACT_SITE 133; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MARQLFLHPVLLAAACLLVSVVLCNAGVAQAAWWWPRWDSLFPSRGQQQHHGGYDYHDNGDGSSKSRVASIVTQELYGEMFKHKDDAACPAHGFYTYASFLAAAARFPEFGGDGDLATRKREVAAFLAQVSHETTGGWATAPDGPFAWGLCFKEEITPPIDYCDASSTQWPCVAGKSYHGRGPIQLSWNFNYGPAGQALGFDGLGSPDVVAADPEVAFKTALWFWMTPRAPKPSCHDVMVGRYRPSAADVAANRTAGYGLTTNIINGGIECGKSGVPQVDDRIGFFREYCKLLRVDVGTNLDCAQQQPYSS | 158 |
Q9KU78 | 5.4.99.25 | ACT_SITE 47; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MARRRKGRVIHGVILLDKPTGISSNDALQKVKRLYGAEKAGHTGALDPLATGMLPICLGEATKFSQFLLDSDKRYRVIAKLGERTDTSDSDGQVVQTRPVHVDYDTLLACIAKFRGETDQVPSMFSALKYQGRPLYEYARQGIEVPREARKITVYEIELHRFEGDEVEMEVHCSKGTYIRTIVDDLGEMLGCGAHVTMLRRVGVANYPYERMVTLEQLNALVEQAHRDEKAVADVLDPLLLPMDTAVEALPEVNVIPELMTLIQHGQAVQVSGAPSDGMVRITGGEQKLFLGVGEIDDNGKVAPKRLVVYGE | 218 |
A0A2K2DDB2 | 3.5.1.98 | ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MVPRRVALTHALVDSYGLLHGHGMKRLRTRPATEEELASILNKDYLELLRDLTPHNYSGKRREGAVKRNIVGLTHHDQEAEDDGQQNSDDNPVIAGLWDYCQRYAGGSLAAARALGSRDSDIAINWSGGMHHACRDGASGFCYANDIVLAVRELLRVFPRVLYVDIDVHHGDAVEDQFAEDSRVMAVSFHQHGRRANGGDGEFFPGTGAAGDVGKGEGEYRTPNVPLKYGMDDAGYREMFRPIVGEVMRVFQPEALVMQCGADSLAGDRLGEFNLSVRGHASCVAYLRSFNKPLLLLGGGGYTINHVASCWCYETAVAIG... | 184 |
Q99036 | 3.2.1.78 | ACT_SITE 196; /note="Proton donor/acceptor"; /evidence="ECO:0000305|PubMed:10666621"; ACT_SITE 303; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:10666621" | MMMLSKSLLSAATAASALAAVLQPVPRASSFVTISGTQFNIDGKVGYFAGTNCYWCSFLTNHADVDSTFSHISSSGLKVVRVWGFNDVNTQPSPGQIWFQKLSATGSTINTGADGLQTLDYVVQSAEQHNLKLIIPFVNNWSDYGGINAYVNAFGGNATTWYTNTAAQTQYRKYVQAVVSRYANSTAIFAWELGNEPRCNGCSTDVIVQWATSVSQYVKSLDSNHLVTLGDEGLGLSTGDGAYPYTYGEGTDFAKNVQIKSLDFGTFHLYPDSWGTNYTWGNGWIQTHAAACLAAGKPCVFEEYGAQQNPCTNEAPWQTT... | 172 |
E9H5G0 | 2.7.10.1 | ACT_SITE 211; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MNEDLSLDDQIEILPYDRRWEFPRNRLKLGVQLGAGCFGRVVKAEAVGVKDAEENVQTVAVKMVRSQTNAAALEALVSELKILIHLGAHLNVVNLLGACTKTLIRELFVIVEYCRFGNLQSYLINHRNNFVNQVDKLGNLLIDAAIQEINTAAGMNRFYEYEPPVSFGVCQKDPDSNFYGMSVSTADLISWSFQIARGMDYLASKKVLHGDLAARNVLLADDGVAKVADFGMARKMYYEGNYQQTGQKLMPVKWMAIESLTDRIFSTQSDVWSYGVLLWEIFTLGKVPYPGLEGNTLVRQLEKGYRMEKPDFAPTCMGEI... | 97 |
B3WFY8 | 2.7.11.1 | ACT_SITE 132; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSSAVKLADRYLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLNHPNIIKLREVIRENDILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNGTELVKIADFGLAREIRSKPPYTDYVSTRWYRAPEILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMNFRFQQVVATPMEQVVNTISKEGMKLMMDMMLWNPEKRPNANQSLRYKYFQVAEKLGAPVVSQPAPGSIRKTSAASVKS... | 99 |
A0A6I8NJW4 | 3.2.2.27 | ACT_SITE 182; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MRVRLAPNPWRAGGLAPAPAQWACSPARALLLSAKMIGQKTLHSFFASSAAAGPAGKRHLHCKGPGPAPGDSQGEQVPPAKKAKEEVAAASPPLSPDQLERIRRNKEAALLRLAARHAPGGLAEGWKRQLGTEFAKPYFSKLMGFVAEERKHHTVYPPPEHVFSWSQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQKPVPPPPSLENIYQELSTDVEDFSHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNENLDGLVFMLWGAYAQKKGSSIDRKRHHVLQTAHPSPLSVHRGFFGCKH... | 173 |
C4K4G2 | 2.2.1.2 | ACT_SITE 132; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MMNKLQALRQFSTIVADTGDISAIQSYQPEDTTTNPSLILNATKIPAYRHLIDRSVAWAKRQSSDPKQHQIDATDKLAVDIGVEILKLIPGRISTEVDACLSYDIHASIEKAQKLISLYHEADIHKDRILIKLAATWQGIRAAEALEKLGIRCNLTLLFSFAQARACAEAGVFLISPFVGRILDWYKKNSDTKEFLPTQDPRVLSVQKIYHYYKKHGYETVVMGASFRNTAEILELAGCDRLTISPALLQELSEQQGTVEQKLVFRGALKEKPTPLTESEFYWQHNQDPMAVEKLSEGIRKFAEDQEKLKNVISNLLA | 52 |
A0A9L0SIX1 | 2.7.11.1 | ACT_SITE 323; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MNGKGVRSPSAVALVLHPRKGVDGEAESPRTGSWVTPDTQTSENQVDSAKEFAMGQLVRWEATLQGIMDRSKENCISGPVKTTVPLGDGPKRVPVTQQLPQNLLSANSGQAQRVLCPSNSSHRVPSQAQKLVSSHKPVQNLKQKQSQATSVPHPVPRPLNNTQRSEQLQPSAPGNNSEKELASKEKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGAVYRELQKLSKFDEQRTATYITELANALAYCHSKRVI... | 99 |
Q8LPZ7 | 2.7.11.1 | ACT_SITE 201; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNCCRSPAAAAREDVKSSHFPASAGKKKPHQARNGGVGGGGGGGGGGGGGGGAGQKRLPVLGEEGCELIGGIDDKYALDRELGRGEFGVTYLCMDRDTKELLACKSISKRKLRTAVDVEDVRREVAIMRHLPKSASIVSLREACEDEGAVHLVMELCEGGELFDRIVARGHYTERAAANVTRTIVEVVQLCHRHGVIHRDLKPENFLFANKKENSPLKAIDFGLSIFFKPGEKFSEIVGSPYYMAPEVLKRNYGPEIDIWSAGVILYILLCGVPPFWAETEQGVAQAILRGNIDFKREPWPNVSENAKDLVRRMLEPDP... | 99 |
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