Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
B0V237 | 2.7.10.2 | ACT_SITE 943; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MSEEEEVPLMKSERAGSQRSSCDSALQVHLYYSPSLNSETTFSIPTGHVTAESVCVLAAKASGILPVYHNLFALASEDLSYWYPPNHLFKSEEPVKVYYRVRFFFSSWFGQESRASYRFSLSKGRIFAVLDYAVIDYVFAQSRSDFVTGCGGISPALSLQQECLGLAVLDLWRLAKERNQSLAEICNTTSYKSCLPETHRQDIQRMNRLARYQIRKTLKRFLKKLGKCSAGERSLKLKYLMKLSELEPDYGSESFPLHHSGWLEQSEQQRVLAVKVSGEGGIQIQKTDRQEWQTFCDFPQIIDISIKRLCQEQMPLEGRV... | 98 |
Q83CG2 | 4.2.1.20 | ACT_SITE 44; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 55; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MNRIEQQFKKSPAYVAYLTAGDGGLERSLESLLALAKGGVNILEVGVPFSDPVADGPVIQEASIRALAQGTTLHDVLTLITSFRQHSEIPIILFTYFNPLLAAGDKIYQQMKSAGVDGCLVVDLPVEEAAPHLTACKTAKIAPILLISPSTTQERLKKINEHGEGMLYYVCRPGTTGVRATLPENFPAKMNQIKSMTSLPIVTGFGIANRKMAAQALQYADGFVIGSLFVKAIAEGISKNALTRLAQSLNPHYPNLRLITPFRKKTF | 202 |
D8R3E3 | 3.4.19.12 | ACT_SITE 13; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 106; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 121; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MAIYHERQRLQLCLLHALNNLLQEQHATPWSTRNLFFLPAKQHRNPLTGNYDANVLIAALSSRGLEARWHDRRSAIADDDLSRPNLAGLIANTSSQRFLGLWRSRHWIALRRVHGSWYNLDSDLPMPVAMRGAGEVRDFLNSLRDQGAELFFVFRKEEQGDE | 175 |
P00724 | 3.2.1.26 | ACT_SITE 42; /evidence="ECO:0000255|PROSITE-ProRule:PRU10067, ECO:0000269|PubMed:2113524" | MLLQAFLFLLAGFAAKISASMTNETSDRPLVHFTPNKGWMNDPNGLWYDEKDAKWHLYFQYNPNDTVWGTPLFWGHATSDDLTNWEDQPIAIAPKRNDSGAFSGSMVVDYNNTSGFFNDTIDPRQRCVAIWTYNTPESEEQYISYSLDGGYTFTEYQKNPVLAANSTQFRDPKVFWYEPSQKWIMTAAKSQDYKIEIYSSDDLKSWKLESAFANEGFLGYQYECPGLIEVPTEQDPSKSYWVMFISINPGAPAGGSFNQYFVGSFNGTHFEAFDNQSRVVDFGKDYYALQTFFNTDPTYGSALGIAWASNWEYSAFVPTN... | 164 |
Q9VUL1 | 6.3.4.2 | ACT_SITE 399; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 526; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 528; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605" | MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTFSPYEHGEVYVLDDGAEVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEKERTGEYLGKTVQVVPHITDAIQEWVERVAQTPVQGSSKPQVCIVELGGTIGDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTKPTQSSVRELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIYHVPLLMEQNGVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVCIAVVGKYTKFTDSYASVVKA... | 252 |
D7TF24 | 3.1.1.11 | ACT_SITE 404; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSFKAYGKVNEAEQERLLARRKTRRRITIISLSSIILVAVIVAAVVGTTTNSGGKSKNAGNSVSTSIKAVCDVTLYPDSCYNSLAPMVKSSQLKPEDLFNMSMEVALNELHRTFQRFSEHEGFKGITDKMLAGALDDCYELLDLAIDNLNSSLSSSLDNFDDLKTWLSAAGTYQETCINGFESGNLRSSVLEFLKNSTEFSSNSLAIITEISKLAGSISSRRLMGLPEDKVPKWLSAKDRKLLQSSSTLKKKADAVVATDGSGKYKTISEALKAVPDKSKKSFVIYVKKGVYNENVRVEKSKWNVLMIGDGMNKTVVSG... | 125 |
Q5BH83 | 6.5.1.1 | ACT_SITE 317; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | METDQDMHDQAMAGEETDLDEKYPNRPQNKAPTLPFHDLYETLFRPLREIKKKPVGPAGNRRKAGPHGLSAANLNPIERRRDIIERFISRWRKEVGDDIYPAFRLILPDKDRDRAMYGMKEKIIGKMLVNIMKIDKNSEDGFNLLNWKLPGQSATSSMAGDFAGRCYDVVSKRPMRTEFGNMLIEEVNEKLDQLSSASKEEEQLPILAEFYRRMNPEELAWLIRIILRQMKLGATERTFFDVWHPDAENLYSISSSLRRVCWELHDPNIRLDAEDRGVSLMQCFQPQLAQFQMQSLDRMIARMRPTEDDPVFWIEEKLDG... | 254 |
A0A9J7MKB6 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 119; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MVQLLPLFCLTTIALCGHVDAMPKAVTQLGVMITKVTGRPPWKYWNYGCWCGKGGQGPAVDDTDSCCRTHDFCYEDLGKPPCKWTFKQYVTSYKYTIDGKTVTCGDQKGTCKRTLCECDKALVNCFTRSPYVEKHDHMDQTICKKGNSTEVMDADLPWSFQ | 130 |
Q76P07 | 2.7.11.1 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEIHSVGPFIIGKTLGQGTTGKVKLGFHKDTGFKVGIKIINKELLINKPSMRRKIEREIVLMKLIDHPNAMKMYEVYETSKYLFLILEYVEGGELFDYLVEKGGLESGEALFFFQQIIIGLEYCHSRNICHRDLKPENLLLSGDKRIKIADFGMGSIVRKDMLLHTSCGSPHYASPEVVSGIDYDGQKADVWSCGVILYALLTGKLPFDDENIRRLLNKVKNGAFSMPPYIHKDAQDLLTKMLTVDPSKRISIKEIKEHPWFVSNFNQFQKATPVEEINAEPLVDYSQIDEDIFRSLMALGVGTIDEVKQQLVSNQKSAT... | 99 |
Q27869 | 2.1.1.77 | ACT_SITE 60; /evidence="ECO:0000269|PubMed:14596598" | MAWRSVGANNEDLIRQLKDHGVIASDAVAQAMKETDRKHYSPRNPYMDAPQPIGGGVTISAPHMHAFALEYLRDHLKPGARILDVGSGSGYLTACFYRYIKAKGVDADTRIVGIEHQAELVRRSKANLNTDDRSMLDSGQLLIVEGDGRKGYPPNAPYNAIHVGAAAPDTPTELINQLASGGRLIVPVGPDGGSQYMQQYDKDANGKVEMTRLMGVMYVPLTDLRS | 49 |
A0A1S3XMV6 | 3.1.1.11 | ACT_SITE 496; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFQDFDQISERRKLERQQKMKRRIMIAVVLLLLILAAVAAAVVYLVVFKNKSEDASANKSNKNASTPPSKEPETLKSDATPPPKDDAASTPPKVAAPPPDDGAVPPPKEEGAAVPPVKDAAAPSPPSDNAPALSPQEGDNAAAPALSPQAEGAIGAICAATEFNQTCGDILSKVLQTNASGAQPADLLKATISAAIDEIAKGIDELGKINKDSPEKSTAYDDCMSLLADAKKDLNSSIYILDGGINDVASATAELNNKLSAALTYQDMCVDGYPEADQSTVQTALKKIGEHTINSLAVASELSTTSPKTNNNAKRRLLT... | 125 |
Q5A1E8 | 1.3.5.1 | ACT_SITE 333; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MLTSLRNQVKSSAVTKRLLSSSSVRSQVIGSNVKGQDFNAAKYMSQKYHVVDHEYDCVVVGAGGAGLRAAFGLVSEGFKTACVSKLFPTRSHTVAAQGGINAALGNMHADDWHWHFYDTVKGSDWLGDQDAIHYMTKEAPASIYELEHYGVPFSRNDEGRIYQRAFGGQSKEFGKGGQAYRTCAVADRTGHALLHSLYGQSLRHDCHFFIEFFAMDLMMKDGACIGIIAYNEEDGTLHRFFANRTIMATGGYGRAYFSCTSAHTCTGDGYAMVSRAGLPLEDLEFVQFHPSGIYGSGCLITEGARGEGGFLVNSEGERFM... | 28 |
Q4WUK5 | 3.2.1.39 | ACT_SITE 491; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 590; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MSGPNRTYSFGEGDDSLAHPSSRTHAMHSQYDDVSPISDGARMNPMNGQGMDHGLASVLEDGRQGWGRSPEPSPSLLTGSSATPGMDNLGPGAVGGGISGIALSVANSHDRLSGVEALMGTDGQEANIPAERGLSTTGSDNPYVPEPPEHRYSYGSNIALGAAAAPAGQLTPGQSVSHLSSTNPSQRNLYDIPYQDVGGLNAGPYQRHSAYSSNDLPVDINPDEIVDDGDDGFVPAPNSGSGARKSQAIPAAAGGAAAGGVLGNLGGLFGGKSAADTSYGPVPGAGLEAGEKGRWVKPKPGGGNKKRGWIVGAILAFIII... | 167 |
A9JTG5 | 2.3.2.31 | ACT_SITE 664; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MSLSSGGWTRASPPAQSSSSHLGHEASQSACSTVLMSVKVSVCHSGIRPLCLPGAGDESLRLQLSMDPGKAGEFRLALRDISATAAGRSVFIAEFDLKTVQYEVKTPLCHELSLATPPHDRISFKFRCEQEAQEWATVVMSSLREAHRVAISSSTEEGRLPPPPLATQSKAPMPRTEEICAELVSAIEAGDVRSASVCASSLAKQKAALSIQPSKRNYTDSEVCLAVVVEDASSSCCVSVKVFPHSTIGALKQQVFSDYGFHPRVQRWVIGQSLCSDHRSLASYGVQRDGDTAFLYLISARQARLSRGIYQQDQESALLM... | 67 |
T1EXC7 | 2.7.11.13 | ACT_SITE 349; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MQLMSERFNINIPHRFVLNSFMSPTFCDHCGSMLFGLFKQGLKCEECGATCHKKCYKFVPNLCGINQKILNELLETVKNSNLSLTPGKQLAPCSKSSEVTRRVPPSKAPSKSIDSSAASSFSSTATQLEKASIDTVYSILSSELASINLRESLLSESSTDEDDIMKQPCSVHMSGIRSDSKRTSQMVLHQISPSLATKKSKRTSIFIMPEPTKKTKKFAVDDFKMLKVLGKGSFGKVLLVEMNNEADSDLYAMKVLKKDVVLEDNDVESTLVERRVLELGNQCPFITKLICTFQTSNHLFFVMEYLSGGDLMFHIQRNRR... | 100 |
A0A1S4A3U5 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDNNHNHFSLSSRFLLLLLPLLLHIHHVRSELQLNYYLESCPRAEEIIKEQVAQLYHKHGNTAVSWIRNLFHDCMVKSCDASIYLDTANGQESEKTSPKNFGMRNFKYVETIKQALESECPNTVSCADIVALSARDGLLWLGGPRVEMRTGRKDSKESYLAEVESSLPNHNDSMSSVLSRFQSIGVDTEGTVALFGAHSVGRVHCVNLVHRLYPTVDPTLDPDYAKYLKGRCPTPNPDPEAVLYSRNDRETTMILDNMYYKNILNHKGLLIVDQELVTDSTTSPFVEKMAADNGYFHDQFARALLILSENNPLTGDQGEI... | 14 |
A0A2K1L8S5 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGGGPTAMLSVLALLVASLAALSTTVQAQLVENFYRTSCPSAETVITSAVNSALNRRAASAAGVLRIHFHDCFVHGCDASVLIDSPSEKDAPPNGSLQGFEVIDAAKTAIEKRCPGIVSCADITAMASQIAVKKLSGGKITWKVPLGRRDGLVSSAADVAGKLPAPTANVATLKSIFAGVGLTTEEMVVLSGAHSVGVASCRAVQNRLTTPPDATLDPTYAQALQRQCPAGSPNNVNLDVTTPTRLDEVYFKNLQARKGLLTSDQVLHEDPETKPMVAKHTSQGVFNEAFKNAMRKMSDIGVLTGSAGEIRANCHRFNA | 14 |
A0A5F8GQ53 | 4.2.1.11 | ACT_SITE 206; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 339; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSILKIHAREIFDSRGNPTVEVDLHTHKGIFRASVPSGASTGIYEALELRDGDESCFLGKGKRRVFPITHLPSLLQKMNVVEQDHIDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAERCIPLYRHIADLACKEDLILPVPAFNVINGGSHAGNKLAMQEFMILPIGAPSFKEAMRIGTEVYHNLKNVIKEKYGQIATSVGDEGGFAPNILENKEALDLLKEAISKAGYTDEVVIGMDIAASEFRRDGKYDLDFKSPDDPSRYVTAKDLMDMYKSFIKDYPVVSIEDPFDQDDWEPWTTFTADAGIQVVGDDLTVTN... | 200 |
A0A8M2B8G6 | 2.7.11.1 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MDTAGVSHTDPLDDYELIHRIGSGTYGDVFKARSIKTSVIAAIKVVKLDPGDDISSIQNEITMMKDCTHKNIVAYFGSYLRNNKLWICMEFCGGGSLQDIYHVTGPLKERQIAYVSRETLQGLHHLHQTGKMHRDIKGANILLTERGDVKLADFGVAAEINASVAKRKSFIGTPYWMAPEVAAVEKKGGYNQLCDIWAVGITAIELAELQPPMFDLHPMRALMLMSKSSFQPPKLKEKNKWSTEFHSFIKMALTKNPRKRPTAEKILQHAFVMQLLTRNLVIELLDTVNNPDLQQTQTMDESDLETCSVLPDKIHSLAKL... | 99 |
Q5AWA8 | 3.4.19.12 | ACT_SITE 228; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 651; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MIYLNYGHRLPLKPFIEKTREEPPHKISKLAINAETDEDRYDTSTRVVCYSCGRDDVGEPSGKLQSVIEGVMHATTFSKREEIKAWEQEFIPCEHTTGLIQQESKRIKSQGCGRSQFGGTGGNSHGLAHFNATSHAVAVKLGSITADGSADIYCYKCNEERIDPDLATHLYHWGIDLAGREKTEKSLMEMQVEQNLKWDFLMTTEDGQDLTPVFGAGLTGLSNLGNSCYLSSVVQCLFDLPEFQRRYYHPNEDPPLAETPAADFETQLRKLADGTLSGRYSRPDDKTVASPKPQEIRHQKGLAPSMFKHLIGRDHPEFST... | 175 |
Q10364 | 2.7.11.1 | ACT_SITE 392; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MMNKWAKNWFGLSKKSVSTNSAKGSLPRSPLASIQTNQPVEEGEGGSLPSVSNLGPSSIDHPMEEFASDQSTVGNRNSNDILPEVDHEPSGYLKLQIGSLVLGGPHTDAALAMECSRLNQLFVVVQFGTTEFVSPPLKWESPGRDIGTSSRDSANVSRSSSMMSSHPIPTPAIQRTSSIPNPLTPSYVVFDVAKPVPIDVNIYDHGNNNEFVGRTYIHPSYNYGQFEQFCNSVEVSPAYNRMVDLRLSLNTVFQPLSQHSYGPDDFVPLKLIGKGTFGQVYLVRKKDTERVYAMKVLSKKVIVRRKEVAHTVGERDILVQ... | 99 |
A0A3B6RDV9 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSRLSMATLLLLSLALATAPRLAVVEAVVVEGLRVGFYNRTCPDAEQVVRDVVMNDYAMDHTIAPGLIRIFFHDCFITGCDASILLDESPSGDIPEKESSANGFTLHGLQTIDVAKASIEAMCPRTVSCSDILSFAARDAAVAAGLPSYEVAGGRRDGTHSRMDDLPGNFPVPGHTVPRLTELFASRGLSQEDLVTLSGAHSIGGAHCFMFSNRIYGFSKTADIDPSLDPAFAQRLRKMCPRPRPDDNPQQAPKVNFDERTGEKLDNAYYQELLARRSLLTSDNTLALDPQTRPLVEQYAKDDALFQQRFGEAMQKVSAL... | 14 |
Q9LW44 | 3.2.1.78 | ACT_SITE 202; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 322; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036" | MKCLCFIVLLAIVIAQSYVGVEAAPSDGFVSRNGVQFILNGKPFYANGFNAYWLAYEATDPATRFKITNVFQNATSLGLTIARTWGFRNGAIYRALQTAPGSYDEQTFQGLDFGIAEAKRVGIKLIIPLVNNWDDYGGKKQYVDWARSKGEMVSSNDDFYRNPVIKEFYKNHVKTMLNRVNTFTKVAYKDEPASMAWQLMNEPRCGVDRSGKTLMAWINEMALFVKSVDPNHLLSTGHEGFYGDSSPERKNSLNPVSANTVGADFIANHNIDAIDFASMHCGSDLWFQRLDQNSRLAFIKRWLEGHIEDAQNNLKKPVIL... | 172 |
Q852N6 | 2.7.11.1 | ACT_SITE 237; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNNCVGPSAAGQNGFFANVALWRPRPADAAPPALPPPSSAPSDQAPEPVTIPPSEHSSHHSSRSTDPSTPTSAAEQPANKAAPKVKRVQSAGLLADSVLKRDVNTARLKDLYTIGKKLGQGQFGTTYLCVEKATGREFACKSIAKRKLLTQEDVEDVRREIQIMHHLAGHANVVSIVGAYEDAVAVQLVMELCAGGELFDRIIQRGHYSEKAAAQLARVIVGVIEACHSLGVMHRDLKPENFLFIHQKEDSPLKAIDFGLSIFFKPGETFTDVVGSPYYVAPEVLMKHYGREVDVWSAGVIIYILLSGVPPFWDESEQG... | 99 |
Q380S2 | 3.2.1.23 | ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 282; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MIRRTKLLGICGVVLVVVLALTLGLVFGLQSDDDGGDEAERSFKIDYERDTFVMDGKDFRYVAGSFHYFRALPETWRTKLRTLRAGGLNAVDLYVQWSLHNPRDGVYNWEGIANVTDIIEAAIEEDLYVILRPGPYICAEIDNGGLPYWLFNKYPGIAVRTSDANYLEEVRKWYGELMSRMEPYMYGNGGPIIMVQIENEYGAFGKCDKPYLNFLKQQTERYVQDKAVLFTVDRPYDDEIGCGQIDGVFITTDFGLMTEEEVDTHAAKVRSYQPKGPLVNTEFYTGWLTHWQESNQRRPAQPLAATLRKMLRDGWNVDFY... | 163 |
I1L3N3 | 1.11.1.7 | ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLCKPPLKCLKIVIMANLLTMFFVMEMIIVSGLSFGASGLNMNYYLLSCPFVEPVVKNTVNRALQDDPTLAAGLVRMHFHDCFIEGCDGSVLIDSTKDNTAEKDSPANLSLRGYEVIDDIKEELENQCPGVVSCADIVAMAARDAVFFAGGPVYDIPKGRKDGTRSKIEDTINLPAPFFNASELIKMFGQRGFSARDMVALSGAHTLGVARCSSFKHRLTQVDPTLDSEFAKTLSKTCSAGDTAEQPFDSTRNDFDNEYFNDLVSNNGVLTSDQTLYNSPQTRNIVNAYAMNQALFFLDFQQAMVKMSMLDVKEGFKGEV... | 14 |
A0A078HFU7 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAVKISTISALVVFLALLSLSHFSHGELQLGFYNKTCPDVEKIVFGVVQDAFRTNSRLAPLMIRLYFHDCFSNGCDASLLLDSTTSEKTAGPNLSVDGYALIDAIKDELEIKCAGFISCADIIALATRDLVNLASGGKARYEIPTGRFDGRESLASSVNLPGPQMSVSDTVEMFEKRNLDLTDMVLLLGGHTIGKTHCSFIKDRLYNFENTQGPDPAMDPKLVKELKRECPENSKQNKAINLDQNVSSSNIVDASFYKQIKSGRGILQIDDQLATDEMTEQIVTDLAEGDDFLARFGQAMVKLGSFGVKNKDAGEIRKSC... | 14 |
Q9VKY3 | 3.4.21.92 | ACT_SITE 124; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 149; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MLKTAVSRFLQISSVQCGGRANSVRNINLIPMVVEQTGRGERAYDIFSRLLKERIICLMGNITDDISSTVVAQLLFLQSENVNKPIHLYINSPGGVVTAGLAIYDTMQYVKPPIATWCVGQACSMGSLLLAAGAPGMRYSLPNARIMIHQPSGGAQGQATDILIHAEEIIKIKRQLTNIYVKHAKNTYEEMSGRMERDHFMTPEEAKVLGIIDHVLEHPPETVSETGPASDGGVTSGKAVPEECEKKRSKQAA | 179 |
A0A9J7K9F9 | 3.1.3.16 | ACT_SITE 113; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 115; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MADRCINTCVLQPELYGHPEFLPGLSWFSYQEVGTGRRDQFLSHHAAAPVTTVAKKRHRSIFGSLLCCFRANSSHTPAAPGQPEENGSAKVPQKYLLPPVRHQDMHKKCIVIDLDETLVHSSFKPVTNADFIVPVEIDGTVHQVYVLKRPYVDEFLQKMGEMFECVLFTASLAKYADPVADLLDKWGVFRARLFRDSCVFHRGNYVKDLSRLGRDLCKVIIVDNSPASYIFHPDNAVPVASWFDDMSDTELLDLIPFLEGLAKVDDVYSVLRPQNHHVS | 144 |
G1KTH3 | 1.1.1.8 | ACT_SITE 221; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MQKLRNHTQWHDFKNPSDIISLSSSFSVPCRGSAIAKIVGSNAAKLDKFDNTVNMWVFEEEVGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDILKASEGADILMFVVPHQFIGKLCDQLKDHIKKDAIGVSLIKGVDEGPDGLKLISDIIREQLGIEMSVLMGANIANEVAEEKFCETTIGCKNIEHGQILKELMQTPNFRITVVKEADTVEICGALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCKGSVTSATFLESCGVADLITTCYGGRNRKVAEAFAKTGKSIEQLEKEMLNGQKLQGPQTS... | 7 |
P0C5D5 | 1.11.1.24 | ACT_SITE 112; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P0AE52" | MAFAVSTACRPSLLLPPRQRSSPPRPRPLLCTPSTAAFRRGALSATTTPTPARAALPSTTGRNRIVCGKVSKGSAAPNFTLRDQDGRAVSLSKFKGRPVVVYFYPADETPGCTKQACAFRDSYEKFKKAGAEVIGISGDDAASHKEFKKKYKLPFTLLSDEGNKVRKEWGVPADLFGTLPGRQTYVLDKNGVVQYIYNNQFQPEKHIGETLKILQSL | 12 |
A0A1S3YFK9 | 2.7.11.1 | ACT_SITE 325; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 342; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MAEPADKLEKPQKAENEKEAAVVDEELEEEEEEEEEEEEEEEEEEGELSWSSDSEIGEALDYLDTKDDSESINGAFSLQTRRPNAHGGLHSRPNSSALQPLSNRTQKFSNHIIASPLEEWEGRIKVGMSNSVTTAIRGSVRDMAIGRTKTTEKADRATVEQAIDPRTRMVLFKMLNRGVFHDINGCISTGKEANVYHATKADGQELAIKVYKTSVLVFKDRDRYVQGDYRFRYGYCKHNPRKMVKTWAEKEMRNLMRLRAAGIRCPAPILLRLHVLVMEFIGKGGWAAPRLKDAALSLDKLRECYVEIIMAMRTLYQKCK... | 99 |
A0A0D1EA79 | 2.3.1.48 | ACT_SITE 444; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MASATLSATNQRDEAQSTLLAIGSACQVYDSKTGESYPATVLSRRSGSSSTPPSAGADTDNVQYYIHRHDQDKRMDGWVDCSSIRPLSKLSSLDVKLTSAPTKGVNGNAIPHSLEKGKRKAEHDLINQGSDASRTPSVSRQASPAPADRSSNHRGRHKTTASSPSDTPALRNIDRVLYGSYDIKTWYYSPYPLDHDDDGPENSTAHSASAALSNNRRNQSPSTLRAGASASKRAVRGDSTSGLGGALATSARDAPAIKSLAASTTIDTVTSSGRQSPASPSVSSGTIRGKKDHLIPTKMLWICDGCFKYIKTYSGFAAHR... | 61 |
Q5QXJ4 | 1.3.3.3 | ACT_SITE 108; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MHNDYLKQVKSYLMSLQDAICQQLAQADGEQSFQEDSWDRPGGGGGRSRIMKNGAVFEQGGVGFSHVYGEKMPASATAHRPELEGRDFNACGVSLVMHPENPMVPTVHMNVRFFIAQKEGEEPVWWFGGGFDLTPFYPFDQDIIEWHQQAKNALDSVDEKLYPEYKAWCDDYFFLKHRDEARGVGGIFFDDLNDRSFDECFSVIKAVGDAFTKAYLPIVERRKNLAYTQQQRDFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLARWEYNWQAEPGSAEEQLTEYYLKPRDWLSV | 27 |
A7SG79 | 2.3.1.41 | ACT_SITE 161; /note="For beta-ketoacyl synthase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000447-1" | GLVTPLGSGTEYVWRRLINGACGLACISDKGSQQNMENMAWHATGFVPAGTGEGEFDQTSWHKSRSTSDEAYFAVAAAQEAFDSCGWTPATQEEKEKTGVSIGTGIGDTKGLPEMGAILKNQGYKKVGPFFVTRSLLSMSSGIVSMYFNLQGPNHAVATACAAGAHAIGDAYRMIAHGDANVMLAGGTESAITPLCMASLCKARALTTKYNDSPHEASRPFDRDRSGFVIAEGAGILVLEEHQHAVSRGAHIYAEMLGYGLSGDAHHITAPSQDGRGAYLAMSNALRDAGLSPSDIHYINAHATSTPLGDAVENRAIVRL... | 60 |
A0A5F8GR19 | 2.7.10.2 | ACT_SITE 282; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630220-1" | MLRRFPGLEFSFPFLTRLRLRLYTRLEGSSMQAEEGTGWLLELLAEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRLDAEFSTPQSQNTFRKTSPIPGISVGEGSLQSLTCLIGEKDLNLFEKLGDGSFGVVRRGEWDAPSGKKVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHR... | 98 |
B3RR75 | 3.1.3.1 | ACT_SITE 109; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MSMAHFLLILASLSWVSSQLTSPQINSQWYKDGENVLKQKLNAKNIEKTGKNAILFIGDGMSIPTEVCARIFQGQKRGQTGEENNLSWQLFPNVGLSKTYSVDFQVPDSAATATAFLSGVKTNDGVLGLNQNGIKGQCASEKNNHVNSLVAIAEELGMSTGIITTARVTHATPGAAYSHCASRNWEANIPSSQAGLGCKDIATQLLDAYNIGDGFEVVMGGGRCNFHSINTTDPEYTTFKGCRFDGKDLIQEWKNKKLSNSAYVWNLTAFNAIDPNKTDHLLGLFDPSHMKYDADRLTDKAGEPSIAQMTEKAIQILQRN... | 141 |
A0A2C9VQI0 | 3.1.3.3 | ACT_SITE 89; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 91; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MEGLVHSQVNPIHVTCKHSGSRFIPAFSLQLKKYLTRGGILFMKPPQSFSSVTASVQPLKAVSLDHFHNTVPSKEVLELWRSADAVCFDVDSTVCLDEGIDELAEFCGAGKAVAEWTAKAMGGSVPFEEALAARLSLFSPSLSQVQDFLAKRPPKISPGIDELVKKLKAKNTDVYLISGGFQQMINPVASILGMPLENMFANQLLFGSSGEFLGFDAKEPTSRSGGKATAVQHIRKVHGYKTLVMVGDGATDLEARKPDCANLFICYAGVQLRETVAAKADWLVLNFADLINSL | 147 |
A0A2G2ZPZ1 | 1.11.1.7 | ACT_SITE 185; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MITENVLLAQELAHGIKQDNLGGNMIIKLDMAKAYDRMSWNFLMVVMRKIGFAEDWKSWNSKGQQWRDGDGFFNSQGMYQQQQGLTNFTLELDSMIIVNMVNNRSNNNYKLKQIIDNIIEIVSVKCPVHFQVTEAQGTQPIVKGLSWNFYESICSNVESIIRRRLQDVFRQDIGQAAGLLRLHFHDCFVQMVQQVDQSEKDAPPNLTLRQEAFRIIEDLRRRVHRDCGRVVSCADITAIAACDFVFLSGGPDYDLPLGRRDGLNFATRNETLANLPPPSFNASLILSSLATKNFTPTDVVALSGGHTIGISHCTSFVDRL... | 14 |
O68816 | 4.2.1.20 | ACT_SITE 53; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MSGNVQLLNDTLAAAKSEGRAALIAYLPAGFPTVTGGIEAVKAALDGGADVVEVGLPHSDPVLDGPVIQTADDIALRGGVRIADVMRTVREAHEATGKPILVMTYWNPIDRYGVERFTAELAEAGGAGCILPDLPVQESALWREHADKHGLATVFVVAPSSRDARLAEITAVGSGFVYAASLMGVTGTRASVGAQAEDLVRRTRATTDTPVCVGLGVSNAAQAAEVAGFADGVIVGSAFVKRMLDAPDDAAGLEGVRALAADLAKGVRGQA | 202 |
B6K069 | 4.6.1.16 | ACT_SITE 196; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 204; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 235; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MPPYPIACLNGQYLLFDLEAVKEFRCKYGILGMLTGTLAQLPQQNVFLGLPVQLMNEEAYYLVKHGLAYLVDDVASHESTRAEITKYHVEQVHTQRRELAQEQHTENNRRQYEKKRLAMQKLGRPPPPEPSPAEDRRSDLLMVPVRTASNRELYAPQDSHIFPEVEMKRYHAFEYLLARKFCLNPGLRFGCHFVAYPGDSLRYHSHYLVNSYNWNEEVPVVNIIAGGRLGTGVKKAWLMCGTKSSSSKRNDTASTRCFSVEWAGFG | 207 |
Q4WL79 | 3.2.1.21 | ACT_SITE 225; /evidence="ECO:0000250" | MTPKFDIDYVLANITEDDKIALLSGSDFWHTHAIPKFNVPPIRTTDGPNGIRGTKFFAGVPAACLPCGTALGATWDRDLLHQAGVLLGKECLAKGAHCWLGPTINMQRSPLGGRGFESFAEDPHLSGIMAKSIILGCESTGVISTVKHYVGNDQEHERRAVDVLVTPRALREIYLRPFQIVARDAHPGALMTSYNKINGKHVVENPAMLDIVRKDWHWDPLIMSDWLGTYTTIDSLNAGLDLEMPGPTRYRGKYIESAMQARLIKQSTISKRARKVLEFVERASRAPVSADETGRDFPEDRALNRTLCANSIVLLKNDGN... | 161 |
A8XUK9 | 2.7.11.1 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MSADVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDTLAAVKVVKLEAGDNFAVIQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKVSFRSIHRDIKGANILLSSNGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMLCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWSPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLGSLSARMTRDLLDKVNGAPSDVYDRMSKTVDDLTEEESDMD... | 99 |
Q94517 | 3.5.1.98 | ACT_SITE 139; /evidence="ECO:0000250" | MQSHSKKRVCYYYDSDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFNVGEDCPVFDGLYEFCQLSAGGSVAAAVKLNKQASEICINWGGGLHHAKKSEASGFCYVNDIVLGILELLKYHQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNIPLRDGMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSLTGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRCWTYETSVALAV... | 184 |
A0A2R6XGW8 | 1.1.1.37 | ACT_SITE 214; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MEAGNARLARIAAHMRPVRTEESSIRREYTRAKGASAGFKVALLGACGGIGQPLALLLKLNPLVSTLHLYDVVNTPGVTADISHTDTTAVVRGFLGQAQLNAALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKTLIEGVAKSCPKAIVAIISNPVNSTVPIAAEVLKKAGVYDPKKLFGVTTLDVVRANTFVAEVIGVDPKEVNVPVYGGHAGITILPILSQVSPPFSFSKDEVEYLTNRIQNGGTEVVEAKAGAGSATLSMAYAAAKFAEAALRGMRGESDVVECAFVASEVTELPFFATKVRMGRGGIEEIFPLG... | 5 |
A9SKT7 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGGLDFSRRSSAAESCFVVVIALSLLLVTQVRAQNIGVGFYDQSCPRAESIVTETVREFNSRDATVPAALLRLLFHDCFVEGCDGSLLLDPSPENPDVEKAASPNLTVRGYDVIDAAKARLEVECPQTVSCADIVALAARDSAVLAGLNFQGLPLTMATGRWDGRVSSRNAAEAALPSSKSNVQQLTAQFSNKGLSQDEMVTLSGAHSIGVAHCSNFMDRLYDFPGSPNGVDPTLDPDYAAELQAKCPRGNPNPNTVVNMDPQTPFVIDNNFYSNGFAGKVLFSSDMALFNDFETQFTSDLNVVNGITWNQKFGNALAQM... | 14 |
Q54DC8 | 2.7.11.1 | ACT_SITE 1063; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKSFLNKNKNSKKIIILDDNDFSKYQQRYDLQNQNIEIVSSPLQNIRSQQINDGVQMSGSIQSDLSSSDNFTSSGGFGGGGNSSSNTSNRNSDNSTQRPLMVDIGLEYKYRLALEQNPNDFKALVKWGSLIYKNIKNQMGGKHVDVCLMDWNEELIPIPQNNNNHHNHNHHNNHTSGNFTGNINSNTTLSNSFFETLNSFNLREPLFDVCGKYQSSLQLSGGSNLLNIPFSTLLNYNLNEQLNILVNNLNNSSPSSSSSSIKTKNTTSTTTTTTTTKNLNDISNNINNSRVLRSVSLPPAPPPPPTEDPNSPWSDPILWM... | 99 |
Q96V54 | 3.4.19.12 | ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 417; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MGSFLKSFRKDVGSAAPSVGAPPAKKEPQPLPMTPLEKMLTELGPIRGDGSDKFYGMENFGNTCYCNSILQCLYYSVPFREAVLNYPKRTPIEDLEAALAKALRYQDPNARLEAEALAEKQKAANSPRPGQPPNPQQKPEDKDSPEYKKKLALQTLPLLETTDNSVSYGIPESLFSSLKDMFESIVGSQSRIGIIRPQHFLEVLRRENEMFRTAMHQDAHEFLNLLLNEVVVDVEKAAAKLLESPQPASDVSDSVIPSSSSGSRTPNTTRWVHELFEGLLTSETQCLTCEKASQRDEVFLDLSVDLEQHSSVTSCLRKFS... | 175 |
A0A1U8F029 | 1.11.1.7 | ACT_SITE 86; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNSFNTKLAAIALLFCLILSLSAFAEASSKKYYKNKPKPKPGKSTFGVGFYSRSCPPAEGIIKKVVFKAVLMNPGIAAGIIRMHFHDCFIRGCDGSVLLDSVNGKETAEKDSPINNSLRGFEVIDEAKALLEILCPRTVSCADILAYAARDSALFVGGINYALPGGRRDGLVSLSSEVIQNLPPPFFNAQQLQDNFKRKGLSLDEMVTLSGAHSIGRTHCSSFSNRLYGFNATHPQDPSIDPRYASFLKSKCPRPISDTQVDPMVNLDVSSPNHLDNKYYLNLRNHRGLLTSDQTLFESALTSKLVMNNVKYASTWKRKF... | 14 |
B8DZ84 | 3.1.3.1 | ACT_SITE 101; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MKMDRIISKALLLSVLILTFVFFSSPLGIALQSSSSLYKGKPVKYIFWFIGDGMGLNHVYLTETFLSRNSQSPSIQKLSFTQFPNTGLMTTYAADSYITDSASAITAMASGKKTNDGVINMDPQLKFKYKTVAETARDLGYKVGVLTSVSIDHATPAGMYAHQPSRNKYYEIALELFESKFDYFGGGGFLQPKGKDGKQKDVYEIAKEKGYRIVDKIDEFWKLRKGDSKVVAINPILDSSKALPYAINRLRGIDMGLSLADFTRKAIELLDNPNGFFIMVEGGKIDWAAHANDAATVIYDVLDFNEAIKVALEFYKKKPF... | 141 |
A0A0A0KBN9 | 3.4.19.12 | ACT_SITE 18; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 132; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 147; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MAREDCGVYHERQKLQLCLLHALNNLFQEKDAFTRANLNAIAEKLVRDVPNQETWTPLSIVFKPHHNTVTGNYDINVLISALEEKGKSVVWHDHRNGAFSIDLDGPDHTCKLMGIVLNVSVRRFGGIWKSRHWVALRKIDGLWYNLDSDLPDPHPFKDTDELRQFLDHVINDNGEILLVMNDRN | 175 |
B9S954 | 1.11.1.7 | ACT_SITE 100; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKQQHGLKEPIMPTYSSSSSSSSSLSFVFTCLLILMLGINSSISILAKTTNTTRRPPRQLSVNYYARTCPQLEQLVGSVTSQQFKETPVSGPATIRLFFHDCFVEGCDASILISTRPGSKQLAEKDAEDNKNLRIEGFESIRKAKALVEGKCPGVVSCSDILAIAARDFVHLAGGPYYQVKKGRWDGKISLASRVTFNLPSANSTVDQLLKLFNSKGLTLQDLVVLSGAHTIGFAHCKQFVSRLYNYHGSKQPDPAIDPRLLKALKMSCPQFGGNEDIVAPFDVTTPFLFDHAYYGNLESKLGLLATDQALFLDPRTKPL... | 14 |
A0A7M7NWY2 | 2.3.1.48 | ACT_SITE 271; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038084-1" | MAGAVANNMDSMRSALEEFISRANDVIEMKLVRSKEDIEDSTRSFAPEFTHQIFGENETVFGYRGLKVQLYFSAARLTPYLTYTFEEKVNPKKFDGVQADPILKPIVEKLEITPMDNLDRFVASLDEDVGFQPMGDLLHSYSNTDEAHGATRHFEIYKCNVMTPGFKEFHSHLQTFLWWFVDASSYIDFDDERWMYYTIFERYPHDGTKRYSTVGYSTVYRYYAYPDKIRPRISQVLILPPFQRQGHGAQFLETMYADFRKDTEVLDITVEDPSDDFVRLRDFIDCRACAQLPSFAPENLPKGLCDAMEKEALEKLKLNK... | 61 |
Q8F3Q2 | 3.1.1.29 | ACT_SITE 23; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MANLKLLLVGIGNPGQKYVHNRHNIGFVILDSLLDSSSVSYQTNSKYSLARTDEDGVTIFYLKPLEFMNLSGKSVAEIAKKNGISPENILIIHDEIDFEFGKLKLKGGGGHAGHNGLRNIVEKLGTNTFFRLRFGVGKPSITSEVPDYVLSNFLPNEKEKIPELVKVSLQKISDWIRERKNGFQKLSDNQ | 127 |
A0A139WI71 | 2.3.2.26 | ACT_SITE 931; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MAFKMSYSFEGNYRTKPEQNLSGASKKISRDVLLQKTHEERRKRQEQRLKLQSAQLLQSHIRSYLVRKHKKEEERAYYDNNFENIPIQVLLSKLLFFYDPVKDNMRLYQISERLLQQNVQINQALGSDTALSWLIKWWLVLCLKSSYHPDMTKLMLNCLDAFVCNTPTIEYLTRKGYYVYLRTLLDNDAKELLQQILSLIYRPFQSLRITQSSQDIILSEFCSNFLKPTFTNNVKTVLIPYLKNKRDFPYEKIIRYLNSGYHFQISNSLFYCILALEPDDYEPTSDSIQVLSTLSVDIHQLKPPVYLISDDSDDESEVQV... | 65 |
O13632 | 3.1.3.48 | ACT_SITE 131; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MSNKSAWQPQFDEIHSSVQEAEGFLQSSNDVQKAIDEVHYPDSLNDLSEISKNLYISSWKTASELVSTSDKGIDYTLSAMSINPNLSVPEQQHLWLQIEDSSSQNILQYFEKSNKFIAFALSKNAKVLVHCFAGISRSVTLVAAYLMKENNWNTEEALSHINERRSGISPNANFLRQLRVYFECNYQLDRSLRPYRQWLFRRYGDFAVLNTRVPSEVAYAETVRARAGQLELRCKKCRFVLASSDYLVSHEPKDENNYSHTRCTHYFLEPIRWMQPELELGNLEGRFDCPKCNSKIGSYKWQGLQCSCLQWVCPALSILQ... | 149 |
G1KIN7 | 2.7.10.1 | ACT_SITE 832; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MIKVQLISTLIYKCQLLALVLMVASTALIIRNTSEIICHLTTRNSTAARESDVSSFQKIPKNAYYFRCSLNSQGIGNVYKAAESVEVDVLESVEIKAEMNITGSITCLWIFREIQNGCNMSLNSDNRHVLSIVFPKIRETEAGNHSLSIQTEMNNYTVIFTFLVRRTPRKPYFIKNERTDTVSCISEGYPKPVIKWFFCNGPDESCGTYIFSPNEDLHGIKKEQVNLKQDSLAYYAHVWCCAANELGRKCTKLYTIDRNVSSRNTVQELFLKVGDPLLLRCRAKYSNFDFENKWYFENKKLMKNMLLEGRLNNGSYWIKN... | 97 |
F7FU16 | 3.2.1.35 | ACT_SITE 142; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MMWAEARTALALTLTLLVSLASAGPRSDETKPTAPPIFTRRPFLVAWNAPTQDCWPRFRVSLNFSVFDVKASPNEGFVNQNLTIFYRDRLGYYPYHDSHLRPVHGGVPQNSSLMEHLERLPEGVRHYIRSPDREGLAVIDWEDWRPVWIRNWQSKDVYRKVSRQLVSLRHPTWSQEQVGKQAQYEFEFAARQFMLETLRWAKETRPRQLWGFYLFPDCYNHDYVQNWSSYTGRCPDVEVSRNDQLAWLWAESSALYPSIYLDPMLKSSSNCRKFVRSRVEEALRVAREHHAGYSLPVFVYTRPTYTQSFTVLSEMDLIST... | 166 |
Q02159 | 2.3.2.23 | ACT_SITE 89; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MSKTAQKRLLKELQQLIKDSPPGIVAGPKSENNIFIWDCLIQGPPDTPYADGVFNAKLEFPKDYPLSPPKLTFTPSILHPNIYPNGEVCISILHSPGDDPNMYELAEERWSPVQSVEKILLSVMSMLSEPNIESGANIDACILWRDNRPEFERQVKLSILKSLGF | 64 |
D6XGL4 | 2.7.7.7 | ACT_SITE 74; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MLRRTFFRLSLDNRENIIRIFTEMADLNNALGEKYKVQSYNRAVRSLKTHLDLPLRTVEDLEKFPGIGSKLLKKAEEIIRTGKLDELEKKTKPKLKAIQELTQIHGFGPRAAATLFDREGIFTVEDLIEKADQIQLTEQQRVGVRYFHDINEKIPMHESILHENFLRECALRRLGSDYEIQICGSYRRRHPFSGDIDAILARSLNAPPLDAPVTTTGVLTILVEYLQEQRYLEATMALGPLKYMGMGRLPPRTTGGATKTYKARRVDIRLIETKSVPTALLTFTGSKNFNVIMRQAAISKGYLLNEYGLFKVGTSDEVRV... | 121 |
Q8TDR2 | 2.7.11.1 | ACT_SITE 360; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGHQESPLARAPAGGAAYVKRLCKGLSWREHVESHGSLGAQASPASAAAAEGSATRRARAATSRAARSRRQPGPGADHPQAGAPGGKRAARKWRCAGQVTIQGPAPPRPRAGRRDEAGGARAAPLLLPPPPAAMETGKDGARRGTQSPERKRRSPVPRAPSTKLRPAAAARAMDPVAAEAPGEAFLARRRPEGGGGSARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKRRHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVMEFCEG... | 99 |
Q8IAW2 | 2.3.2.23 | ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" | MSNLAKKRLIRDFRKLQTDSPFGVSGSPIGNDIMKWRAVIFGPADTPWEGGTFHLELLFGNEYPNRPPKVKFLTKMFHPNIYMDGNICIDILQKHWSPIYDISAILTSIQSLLSDPNPNSPANQEAALLFVENRIEYNRRIKNCVKESFNFIEQKAEEDAEKS | 64 |
Q8RXN9 | 3.2.1.21 | ACT_SITE 186; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q75I93"; ACT_SITE 394; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q75I93" | MEQFFALFTIFLSFAFPGRCSDVFSRSDFPEGFLFGAGTSAYQWEGAAAEDGRKPSVWDTLCYSRNIGNGDVTCDGYHKYKEDVKLMVDTNLDAFRFSISWSRLIPNGRGSVNQKGLQFYKNLISELITHGIEPHVTLYHYDHPQYLEDEYGGWVNNMMIKDFTAYVDVCFREFGNYVKFWTTINEANVFTIGGYNDGDTPPGRCSLPGKNCLLGNSSTETYIVGHNLLLAHASASRLYKQKYKDKQGGSIGFGLYLMGLTPSTSSKDDAIATQRAKDFYFGWFLGPLIFGDYPDTMKRTIGSRLPVFSEEESEQVKGSS... | 161 |
P17336 | 1.11.1.6 | ACT_SITE 73; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 146; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MAGRDAASNQLIDYKNSQTVSPGAITTGNGAPIGIKDASQTVGPRGPILLQDVNFLDEMSHFDRERIPERVVHAKGAGAFGYFEVTHDITQYCAAKIFDKVKKRTPLAVRFSTVGGESGSADTARDPRGFAVKFYTEDGVWDLVGNNTPVFFIRDPILFPSFIHTQKRNPQTHLKDPDMFWDFLTLRPESAHQVCILFSDRGTPDGYCHMNGYGSHTFKLINAKGEPIYAKFHFKTDQGIKNLDVKTADQLASTDPDYSIRDLYNRIKTCKFPSWTMYIQVMTYEQAKKFKYNPFDVTKVWSQKEYPLIPVGKMVLDRNP... | 13 |
A7SUP8 | 3.5.1.98 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MASSDEDEGMHGELLPKVAFIHSEDSVNLCDKLPKVTGRASLTSSLIEAYGLLKDRNIRVIAPRKATASELAAFHSSEYVNCMRRAAEAVSDGSEECEDLVEFGLGYDCPPFEDMYDCVSMIAGATLLAADMLKTGQAKVAVNWQGGWHHAQRDEAAGFCYINDIVLGILKLREKYDRVLYVDLDVHHGDGVEDAFSFTPKVMTVSFHKYSSGFFPGTGSCCQVGHGKGRYYTLNVPLKDGITDRPFVEVFTRVMSRVKAKFKPDAIVCQCGVDSLAGDPMKAFNLTQFAVGRCVKYLQGWNLPMLVLGGGGYNMVNTSR... | 184 |
A0A0H2VZY4 | 2.7.11.1 | ACT_SITE 201; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01497"; ACT_SITE 217; /evidence="ECO:0000256|HAMAP-Rule:MF_01497" | MNNSAFNFQTLSPDLIMDALEGAGLRVDSGLTALNSYENRVYQFMDEESKRYVVKFYRPERWSSEQITEEHQFSLDLAESEIPVIAPLRLNGKTLHTHCGFFFAVFPSVGGRQYEIDNLDQLEWVGRFLGRIHQAARNSLFVARPTMGIEEYLTEPRQLLANCDLVPVKQRDKFLAAADLLITTIKQYWHTEWQPLRLHGDCHPGNILWRDGPMFVDLDDARNGPAIQDLWMLLHGDRRDQSMQLDILLEAYSEFADFDQRELALIEPLRAMRMVYYLAWVARRWQDPAFPKSFPWMAESDFWLQQTASFTEQVKLLQEP... | 99 |
D2X8K2 | 3.1.1.4 | ACT_SITE 46; /evidence="ECO:0000250"; ACT_SITE 95; /evidence="ECO:0000250" | GVWQFAYMIAKYTGRNPLDYWGYGCWCGLGGKGNPVDAVDRCCYVHDVCYNSITQGPRPTCSRIAPYHKNYYFTGKKCSTGWLTSKCGRAICACDIAAVKCFRRNHFNKKYRLYKKNIC | 130 |
Q81IH1 | 5.6.2.1 | ACT_SITE 310; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383" | MSKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDKVKLNKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASAVARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIASREDEIKNFKAQTYYGIEAQTMEKLKLTWQDANGNSRSFNKEKIDGIVKRLDKQNATVVEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISS... | 221 |
D0G6X8 | 3.2.1.52 | ACT_SITE 336; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MAMERHGWRWLPGLLALLAALVVPKGWARDTSGAESLGLWPLPFAVDISPRSLHLSPNNFFFGHSPTSKAGSSCEILQEAFRRYYDFIFGFYKWHQGSYQLCFGTELQQLQVHVESECDTFPSISSNESYVLHVKGPEALLRANTVWGALRGLETFSQLIYQDSYGTFTVNESEIIDFPRFPHRGILIDTGRHFLSVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSINFPLLSSKGSYSLSHVYTPNDVRMVIEYARIRGIRVMPEFDTPGHSRSWGKGQKDLLTPCYRKQVLSGTFGPINPILNTTYNFLSKFFKE... | 170 |
A0A8M9PT21 | 3.1.3.16 | ACT_SITE 1057; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 1059; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MSTCTLLLVSQAGCGLNESLQPCEPPLQTQSCRICRKSKPMGECLECFPSSDLCRCFGERMSFVESNITKYLESSAFFKSEHAEVNMPAELCFDHSEVSGQGDPKKEDQSLERAAESCAEQDTPIDQSTIKLHEVDGLCIENSRINGEFSDQSGSSGYSSLLDSCSEHSESFEASGSSVDLVEMSQNDELSITFDPSDQSEFSEHDEEQLTLSEVSLSDCESFQQDDSEQIVLPEMILDDCDSFEQHNEEPLDASEMSPDLYEFVSFHQDDEEIDLSEMSLVDQDAAEQEDLSDSFQQGHVEPNPLDPLDYETLSECDAE... | 144 |
Q05B57 | 3.4.19.12 | ACT_SITE 157; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 160; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 267; /evidence="ECO:0000250|UniProtKB:Q5VVQ6"; ACT_SITE 342; /evidence="ECO:0000250|UniProtKB:Q96FW1" | MFGPAKGGHFGVHPAAGCPGGVSQPAAGTKAGPAGVCPVGGRTNAMWRLRCKAKEGTHVLQGLSSRTRVRELQGQIAAITGISPGCQRILVGYPPECLDLSNGDTILEDLPIQSGDMLIVEEDQNRPKTSPAFTKYGAPSYVRETLPVLARMAVPADNSCLFTSVYYVVEGGVLNPACAPEMRRFIAQIVASDPDFYSEAILGKTNEEYCDWIKRDDTWGGAIEISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLHLVFPDPDTPPLTIFSSYDDIVLVQALELADEARKKRQFTDVNRFTLRC... | 175 |
A0A3Q7HXF7 | 2.3.2.26 | ACT_SITE 805; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"; ACT_SITE 1617; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MADQLPHDTSTKRKLNDHTGASTARMRHNQILFNSSLRSPIQFFVRMFSGKTLVIQADSSDTVASLHWKIHSITGIRPIQSTSSAVPSMQEGLIYRGKQLELSQTLSECGIQNDDTLQLVRRMRSMHHPQTWKLMSDLNLIIDDLCNCNDNPNIITYVTRLSNMLTDFLIKTPNYSADGSEEYLHIFIHSSVPSSLVKLYVSPSLITKQAAHGCICQFVQNCLNHFTNPTTVYRLIAPILFEFCTILRGAAGVDDDLYLFFRSRLAAMMVENVHDVKHVLTLHHVFPFVDELATTLSHSLELSAQSPDFKQLSDSDVLVF... | 65 |
Q5N3S5 | 1.3.3.3 | ACT_SITE 121; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MTVATPNLTTVPVPPSDSRERVKQFMQTLQDEICAGLEALDGGGQFREDSWERPEGGGGRSRVIREGNVFEQGGVNFSEVWGEKLPPSILAQYPEAAGHGYFATGTSMVLHPRNPYIPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAKHFHSSFKAACDRHYPQFYDVFKLWCDEYFFLKHRGETRGIGGIFFDYQDGRGDLYNKGPAPSGPAGQKAAEVGIVSDLNWEKLFAFAQDCGRTFLPAYSPIVERRKDTPWGDRERQFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYMYQPEAG... | 27 |
A0A3B3IGG7 | 2.7.10.1 | ACT_SITE 1163; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1" | MPQSRSSRLNADRRTSRPRSGAAPAPAGEAMWPRMSGWVVAALCAALLGCHPAHADICPSKDIRNNVTNLQTLENCTVIEGHLKILLMFKTKPENFRGISFPKLRVVTDYLLLFRVYGLESLSDLFPNLTVIRGNNLFFNYALVVFEMLQLRELGLHSLMNITRGAVRIEKNPDLCYLSTLDWSKILDTVEDNYIVANKNDRECGDVCPGVPRGETLCPTTTLNGHFSERCWTQKFCQKMCPVQCKHGACTDGGQCCHDQCLGGCLKPNSTSDCVACRGLQHEGRCVEQCPKKFVVYKGWRCVSSDFCQELHHRCRREKE... | 97 |
A0A022QI62 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPGLTIGDTLPDLEVETTHGNIRLHDYVDQSDFTIIFSHPGDFTPVCTTELGMMAAYADKFAERGVQLLGFSADDVDSHNQWIKDIEAHNGGHKVTYPIAADPHRHFIKQLNMLDPDEKDSSGNQVPSRALHIVDGRDKKIKLSFLYPATTGRNMDEVLRVLDSLQRASESQHKIATPANWKPGEPVVISPSVSSEEAKQMFPQGYNTAHLPSQKDYLRFTNVN | 12 |
Q8ILU6 | 3.2.2.27 | ACT_SITE 169; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MNNPTIQKTIDQFFKVKRKSSILSGEIEKKRKKVILEEVEEKSLEGSLKEENVNILKTKKLMNNDEDIEKMGTISNISMSTSTIDNEINNNVKQNVCEQGYMEEIKKLMHIEWYELLKDELKKNYFKNMYLKIKEERKTKVIYPPEQLVFNAFLKTPLSNIKVVIVGQDPYHQKDQAMGLCFSVPIGVKIPPSLKNILKEMKQKSNHGNLISWSEQGVFLLNTSLTVEENKPASHKNYGWETFTDTVINIINRQKEKIIFMLWGNFAIKKCKNIDINKHFILKAGHPSPLSIKHFENCNHFAKCNKILAQHNLTPIKWEL... | 173 |
Q4WK02 | 2.3.2.26 | ACT_SITE 1193; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFQSFTGNSRRPRQVNLGGRNTNPFAAYPSGRHLPQGPSAQNTLAIAQQERLLRQQERERLGATRKIQRTWRGYRSRKLTHSTWRTEWDTAERQRTGSSLPFEHKTRTPDDFLEPSLRYATAAECLSQLRLLMQFVEPWNTSDIVRLVYYANAFQITLHEVPTIATEGEWTTPLCRLAKTTLRVLRSALSPIVPDFAVPHLVGLLVFLTNLIPKQMARLAEDYYSVMATITRNIESLSQRCHVSQENLAQSVLALLRPITSETLTAYEWFARSYLTIPDLSAYLGTLDQLAGNINYKLLLSALGPLQSRFRERPQSVTDL... | 65 |
W5N4T1 | 2.7.10.1 | ACT_SITE 835; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | METPWRSLLVLLGAALVVTAGTRGREVCTGTDMKLALPSSKENHYQMLRMLYTGCQVVQGNLEITHLQGAQDLSFLQGIVEVQGYVLIAHTTVESIPLENLRIIRGSQLYNSTLALAVLDNSVSQEAGPGLRQLRLRSLTEILLGGVRIAGSLQLCFPNSIRWTDILDQQNKLRQILDIQERPANCPPCSATCLPQSCWGEGNQDCQTLTYTPCASGCRRCKGPQPSDCCHKQCAAGCTGPKDTDCLACRQVNDSGTCKEDCPPPTVYNPVTFQSEPNKDRKYSFGATCVKECPYNYLATVVGSCTMVCPNHTQEVIVNR... | 97 |
Q8LG98 | 3.4.19.12 | ACT_SITE 89; /evidence="ECO:0000250|UniProtKB:Q96DC9"; ACT_SITE 92; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96DC9"; ACT_SITE 259; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 288; /evidence="ECO:0000250|UniProtKB:Q96DC9" | MQNQIDMVKDEAEVAASISAIKGEEWGNCSSVEDQPSFQEEEAAKVPYVGDKEPLSSLAAEYQSGSPILLEKIKILDSQYIGIRRTRGDGNCFFRSFMFSYLEHILESQDRAEVDRIKVNVEKCRKTLQNLGYTDFTFEDFFALFLEQLDDILQGTEESISYDELVNRSRDQSVSDYIVMFFRFVTAGDIRTRADFFEPFITGLSNATVDQFCKSSVEPMGEESDHIHITALSDALGVAIRVVYLDRSSCDSGGVTVNHHDFVPVGITNEKDEEASAPFITLLYRPGHYDILYPKPSCKVSDNVGK | 175 |
A0A5F8HHD8 | 2.3.1.48 | ACT_SITE 891; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MVKLANPLYTEWILEAIQKVKKQKQRPSEERICHAVSASHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSIKPGTFPKSAKGSRGSCNDLRNVDWNKLLRRAIEGLQEPNGSSLKNIEKYLRSQSDLTSTTNNAAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLEGSGAPKYSNTFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACRIQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPK... | 61 |
F1QFY3 | 3.1.3.48 | ACT_SITE 857; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1" | MTARFRLPAGRSYDVGALEEARERQHAQVECNVLLLDNTVQTFRVNKQDQGQILLDVVYKHLELTERDYFGLQLADDTSDTQRWLDPNKPVRKQLKRPSPHNLRFRVKFFVGDPGKLQEEYTRYLYFLQLKQDILSGRLPCPQNTAVLLASYAVQAELGDYSHSEHLSGYLSEYSFIPNPPQDFEKEVAKLHQEHNGLTPAQSEFNYLNAARTLELYGVELHYARDHCNTEIYVGVLSAGISVYKDRVRVNHFPWFKIVKISFKSKQFFIQLRKELTECRESLLGFNMMNYRACKNLWKSCVENHTFFRLERPVPPERNL... | 149 |
A1L167 | 2.3.2.23 | ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000269|PubMed:24000165" | MKELQDIARLSDRFISVELVDESLFDWNVKLHQVDKDSVLWQDMKETNTEFILLNLTFPDNFPFSPPFMRVLSPRLENGYVLDGGAICMELLTPRGWSSAYTVEAVMRQFAASLVKGQGRICRKAGKSKKSFSRKEAEATFKSLVKTHEKYGWVTPPVSDG | 64 |
Q9LZW4 | 2.7.11.1 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVDSDPVEFPPENRRGQLFGKYEVGKLVGCGAFAKVYHGRSTATGQSVAIKVVSKQRLQKGGLNGNIQREIAIMHRLRHPSIVRLFEVLATKSKIFFVMEFAKGGELFAKVSKGRFCEDLSRRYFQQLISAVGYCHSRGIFHRDLKPENLLLDEKLDLKISDFGLSALTDQIRPDGLLHTLCGTPAYVAPEVLAKKGYDGAKIDIWSCGIILFVLNAGYLPFNDHNLMVMYRKIYKGEFRIPKWTSPDLRRLLTRLLDTNPQTRITIEEIIHDPWFKQGYDDRMSKFHLEDSDMKLPADETDSEMGARRMNAFDIISGSP... | 99 |
A8HAL1 | 3.4.19.12 | ACT_SITE 217; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_03062"; ACT_SITE 752; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03062" | MGKKKVKDRSAGTDSSSETAGPSCTHIRKGTENSVLKKACLNEHWSSCQDCEQDKPEEKQILEDQTDGESPAVWMCLKCGHRGCGRSGNQHAIKHYETPRSEPHCLVLSLDVWSVWCYICDDEVQYSSTGQLAQLITNIRKQVLTAPDKRNASKKSWKEDISVMNSAEQTQDEEKGKKGKQKSSSKQEDSPKSHQSAAAGSSAVVSVRGLSNLGNTCFFNAVVQSLSQTQYLRELLKQIAEEKSSFSITPALSSELDPLQIQLERPGSLTLAMCQLMNEIQETKKGVVTPKELFTQVCKKAPRFKGFQQQDSQELLRYLL... | 175 |
Q0DIT2 | 3.2.1.21 | ACT_SITE 209; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 423; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MCGCASGEDAMETRRPLHPLLLFFSPWLLLLLLLVVQGVRSLQFTRDDFPDGFTFGAGTAAFQYEGAAAEDGRTPSIWDTYAHSWRNPGGETGDVACDGYHKYKEDVMLMNETGLEAYRFTISWSRLIPSGRGAVNPKGLQFYNSMINELVKAGIQIHAVLYHIDLPQSLQDEYGGWVSPKVVDDFAAYADVCFREFGDRVAHWTTSIEPNVMAQSGYDDGYLPPNRCSYPFGRSNCTLGNSTVEPYLFIHHTLLAHASAVRLYREKHQAAQKGVVGMNIYSMWFYPLTESTEDIAATERVKDFMYGWILHPLVFGDYPE... | 161 |
P40235 | 2.7.11.1 | ACT_SITE 130; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MALDLRIGNKYRIGRKIGSGSFGDIYLGTNVVSGEEVAIKLESTRAKHPQLEYEYRVYRILSGGVGIPFVRWFGVECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEFIHSKSFLHRDIKPDNFLMGIGKRGNQVNIIDFGLAKKYRDHKTHLHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLVYFCRGSLPWQGLKATTKKQKYEKIMEKKISTPTEVLCRGFPQEFSIYLNYTRSLRFDDKPDYAYLRKLFRDLFCRQSYEFDYMFDWTLKRKTQQDQQHQQQLQQQLSATPQAIN... | 99 |
Q5BAD7 | 3.1.3.1 | ACT_SITE 221; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MKPTSFAGVALFASGAFGQYFQRLGGCPSLGCVFPPDQADFLPGQHFDIRLEVHSPVNGSEARDGVPDTNFKFTVGKKGQEGVPVTEFFDIEDAELENWQFSWYEDLFAQDAETPSVVNVTSKAYRNLALYEPGEYEAILTYYGKEQTVANWLVRDIPKKRRAKNVVLFVGDGMTTNMITAARLIAHKSINGKYQTKLQLDKFPVLGHQMTHSMDSFITDSANSAAALYGGHKTTVNCLGVYADSSEDPFDDPKFELLPEIFRRQHNGGIGIVSTAFLADATPGAMTSHTRLRSEYDHVISTFLEGITNHTWTEFDGPDV... | 141 |
A0A2R6XKN2 | 2.3.1.181 | ACT_SITE 178; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MASRRLNVIRMGIVGYAQASELQRLLVDRRRAGLIGNTLLSLQHPPTFTVGKRKTMHNLLATPDVLAGLGVEVHESDRGGDITFHGPRQAILYPILALNQMNLGARKYVEGLEDSMINTAALYGVQALGRFKKRTGIWVEDRKLGAIGVKISSGSITSHGLAFNIDPDLEFFTHIVPCGISDKEVTSLRKESYVPIPGEDVVTEQLIESFANVFKLDKHTLDLDDL | 55 |
D8S5X6 | 3.4.19.9 | ACT_SITE 143; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 256; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MAGAIVAIFLALAAIAAARIIQLPEESREKRPLIGILTQPGDGDGRSYINRLEPGDPRRSNISYIAASYVKFVEAGGARAVPLLYNEPWETLAKKFSLINGILFAGGSASLQDGPYYRAGEFLFKRALEANDKGDYFPVFGTCLGLELLAVIVSGNHSILDDYNAHKAAGELNFVGDWAKGRSMFTWFPKDILDKVEHEKLAMQNHIKGLSPQAWRDTQRLRDFFDVLTTTPDLNGKIYISTIEGRKYPVTSVQWHPEKNAFEWGYEGIPHSPDAVRITQSAASFFVSEALKSSHTASWEEEEQLLIYNYSPIYSGRDGK... | 176 |
A0A0A0LNA3 | 3.2.1.143 | ACT_SITE 146; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 164; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 165; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MNYGYLVKENKGIPIHPNIYWRILIELIGALLACAFFCLFPVNDRHVQNLPTINFDYLFAILYDGRSKMQENKIRCIVHYFRRICSNIPVGFVSFERKVLPLNNCAGSFCCPKANFWINSTIPLCQFKVKDSGLIEDQTFGALEVDFANEYLGGGALHSGCVQEEIRFMINPELITGMLFLPAMADNEAIEIVGAERFSNYTGYAFNFCFAGNHEDKREMDSLGRHKTFIAAIDALCSPGMRQYRLEFLLREVNKAFCGFFNQSKYNQYESLFLESGEDVTNHTDKSRNSLPVHESISDARENFLGTSLTPESLDHKDDI... | 159 |
I1HTZ1 | 3.1.1.11 | ACT_SITE 384; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPPPPLRLLFILLLLFHIPFSLSSGHSHSRRHRAPAPSPATPPAASDTAPLPVLLACNATRFKPVCVSTLSAANATSTPDLLAATLSALRCRIPPAVSTARSILSSSSSNVNLSSAATNCLTLLSISSHRLSPSPAPSLISASAALLHLYDCWSAYKYVNTSRTISDAMAYLNDAIAVSSNYISMLAAQIRYGDDTSRWAPPQTERDGYWPSAAADAEADVDALGVPRGLPADATVCRDGCDYETVKEAVAAAPDDNGGGKRFVVRVKEGVYKESVSVPWEKTNLVLVGDGMGKTVITGDRNADTPGVSTFNTATVGVLA... | 125 |
A0A067DP22 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEGAFAVLVLFVAMAVTSVHCQAGTRVGFYSRSCPRAESIVKSTVQAHFRSDPTVAPGLLRMHFHDCFVHGCDASILINGPNTEKTAPPNRLLRGYDVIDDAKSQIEAACPGIVSCADILALAARDSVVVTRGISWQVPTGRRDGRISLASDTANLPGFTESVEAQKQKFLDKGLNTQDLVTLVGAHTIGTTACQIFKYRLYNFTTTTATGADPTIDATFIPQLRALCPENGDGARRVALDTGSPNRFDTSFFSNLRNGRGVLESDQKLWSDASTKAVVQRFLGVRGLLGLTFNVEFGRSMVKMSNIGVKTGTDGEIRKI... | 14 |
Q2QQR2 | 2.7.11.1 | ACT_SITE 274; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNVCIGPRRNFAKNGLLGILRPRHAAPSSPSQPTTTSRSIPVVLPSAPSSKPPPPTQTAPPVPVVISEPPPPQPQPEPQPAAPSQPPPPQEQPSPPPPASSNTTQQPPPPQQRQQSRAKKPAHIKRISSAGLQVESVLRRKTENLKDKYSLGRKLGQGQFGTTYLCVDKANGGEYACKSIAKRKLLTDEDVEDVRREIQIMHHLAGHPNIISIRGAYEDAVAVHVVMELCAGGELFDRIVRKGHYTERQAAGLARVIVAVVESCHSLGVMHRDLKPENFLFVGNEEDAPLKTIDFGLSMFFRPGEVFTDVVGSPYYVAP... | 99 |
A0A9R0JIH7 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIIRFLLGLILLREMVAGGFRFGVDALSMNYYIMTCPMIEGIVRNAVSSALQDDPTLAGPLLRMHFHDCWIQGCDASILIDSTKDNTAEKDSPGNLSLRGFEVIDNIKDELEDRCPGVVSCADIIAMAARDVVFLSGGPIYDIPKGRKDGRRSKIEDTINLPFPTLNSSELIRVFRQRGFTVQDMVALSGGHTLGVARCSSFKTRLSKFDATHDVDPSLNPDFAKTLSKTCSSGVDKAEQPFDDSRNDFDNLYFQALQNKAGLLTSDQTLFDSPRTRGIVNGYAMNQALFFLDFQRSMVKMSLLDVKEGSKGEVRRDCRK... | 14 |
A0A059B5V7 | 3.1.1.11 | ACT_SITE 209; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLPCSPSMRAIHFALLAALVVSVSVGLLPPATAAAHGSSPATVIDSPLLTQKINTDRAIKVDINGNGDFKSVQAAVDSVPSGNSKWVIIHVRKGVYREKVHIPEDKPYIFMRGNGKGRSIITWAQSSADNVESATFKVEAPNFIAFGISFKNDAPTGVAYTSQNQSVAAFVAADKAAFYHCAFYSTHNTLFDYKGRHYYDNCYIQGSIDFIFGRGQSVFHSCEIFVIDDKRVAIHGSITAQNRESADENSGFVFVKGKVYGISDVYLGRAKGPYSRVVFAKTYLSKTIVPHGWTNWSYDGSTENLHHAEYHCHGPGAESS... | 125 |
E9FS43 | 3.2.1.52 | ACT_SITE 188; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MAWDDSLESMIMLTDANISDSPAFVHRGLLIDTSRNFVSVPVIKKIIDAMSYDKLNVFHWHLTDTHSFPFVSTREPRLALYGAYSPSKVYRPEDIKELVHYATVRGVKIVPEFDAPAHVGSGWEWGERAGMGQLALCVNKEPWPTYCVEPPCGILNPVNDNIYSVLSNIYQDMNDLFQSDIFHMGGDEVNFSCWNETTEIIDWLRARGRNDYSKEDFLYLWTHFQNRSLEEVDKAYGNKQPIVLWTSGLTEDGHADKFLDKERYIIQIWTTGTDQSIAQLYRQGFKLIMSNYDAWYFDCGYGQWVGEGPNNWCSPYIGWQ... | 170 |
P33329 | 3.1.3.16 | ACT_SITE 515; /note="Proton donor"; /evidence="ECO:0000250" | MGNSGSKQHTKHNSKKDDHDGDRKKTLDLPPLTKSDTTHSLKSSRSLRSLRSKRSEASLASNVQAQTQPLSRRSSTLGNGNRNHRRSNNAPITPPNNHYLTSHPSSSRRLSSSSRRSSMGNNNNSELPPSMIQMEPKSPILKNSTSMHSTSSFNSYENALTDDDDDRGDDGGESPSMAKVTRINTSSSADRGSKRTPLRRHNSLQPEKGVTGFSSTSSKLRRRSDNTLPASYPLNAEAGGNGSDYFSNRSNSHASSRKSSFGSTGNTAYSTPLHSPALRKMSSRDNDDSGDNVNGRGTSPIPNLNIDKPSPSASSASKRE... | 144 |
E3JY13 | 4.6.1.16 | ACT_SITE 269; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 277; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 309; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MENDSEKPAVGPLRRKPPTSPIGPPIPIYVSNGEAYIWAVDQVERLRIDYQISGLLTGTLPQLAQQNVFLGLPLQLMPEEVVVLVELGIAVLVDDLKAHRPATVEESTEYQARRDQEIAEERRLTAIREGERRAAAQEVYRSQIAAADQKRRARQQKPPSRTEDGGEGSEEIQQGMLVPDGLDEKSKPAISPVQVPYFVPIHLQSHTPTHTPDHPDVVHHQLDSARRAGLWTFPDNQFQRARSAVFSALWRQGMFLGIGLKFGCDFLVYPGDSLRFHSHFACTVVQDPHKPIAPLSLVSYGRLATAVKKSHLLACWDEHS... | 207 |
B9RR45 | 3.1.1.11 | ACT_SITE 235; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKRLFFSFTSPCLIAFILGLQLLPAANSHSKQVPKDISKLKTWVADNINQFNNRKSDLSERIPRIILNKRLADAESSVRVITVAKRDDQFADFQSISDAIDSIPINNKQRRIIWIKGGEYFEKITINTSKPFITLYGDPGDMPKIVFNGTAARYGTVYSATVAVESKYFMAVNIAFVNSAPMPDVNKTGAQAVAMRISGDKAAFHNCKFVGFQDTLCDDRGRHVFRDCYIVGTVDFIFGNGKSLYLNTTIETVAQGTGVITAQARESVTDSSEFTFIHCNLTGIGNNTYLGRAWKERPRVVFAYAYMGSLINAAGWSTGK... | 125 |
C5XIN9 | 1.11.1.7 | ACT_SITE 92; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAATTTSRPAAAALPLAVLAAAMVVALAAAGDVVEQQLEVVGSRYPPLAPGLSFDFYKKSCPKAESIVKEFLSSAVRQNVGLAAALIRVHFHDCFVQGCDASVLLDSTPTQPSEQLSPPNLTLRPAAFKAINDIRARLEQACGRVVSCADITALAARESVALGGGPAYKVPLGRRDGLAAASNAAVLAALPSPTSTVPTLLSFLSKINLDVTDLVALSGGHTVGVAHCSSFSNRLFPTQDPTLNKFFAGQLYGTCPTDTTVNTTVNDIRTPNTFDNKYYVDLLNRQGLFTSDQDLLTNATTRPIVTKFAVDQNAFFEQFV... | 14 |
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