Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
W5M2S3 | 3.1.3.48 | ACT_SITE 218; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000926-1" | GMSTAVEAEFREIDESGSWSAIYQEIRQQSSELPCKLAKLPENKTRNRYRDVSPFDHSRICLQLGTNDYINASLISVEEAQRSYILTQGPLPNTCGHFWEMVWEQRTRGVVMLNRVIEKGSVKCAQYWPQREEKDMVFEDTNFKLTLISEDVKSYYTVRQLELENLSTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGCLNSDQGPVVVHCSAGIGRSGTFCLADTCLLLMSLRKDPSSVHIRDVLLEMRRYRMGLIQTADQLRFSYLAVIEGAKCIMGDASVQESWKELSNEEDAPPEFSPPPPRPPKRIGV... | 149 |
A0A9R1W9I2 | 3.1.1.11 | ACT_SITE 233; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDCLELYEDAIHHINHSTTYISPTDVEKWLSVAIVNHQACQNGFKDLKKNLLQNFSKSLVDLLADNKPSTSIAYFSKAIETNLVVAQDGSGDFKTITRALKASQHRRTGTDRFVIHVKSGVYKEHIFIKQSMINLTLIGDGIDATVITNNRNCKDGYITADTATVQIWGSGFVAIGITFENTAGPRKQQVIALLSASDLSIFYKCSFKGYQDTLCLLKYRQFYRECDIYGTIDFIFGDAAAVLQNCNIYVRNPLPGQQNTITAQGRTDARSTTGFVMHNSHFTAAPDLILAQESGVGSIRTFLGRPWKDYSRVVFIKCYL... | 125 |
B4FXQ4 | 3.4.19.12 | ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 20; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 131; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 131; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 146; /evidence="ECO:0... | MEAASNGGLLYHEVQEGKLCAVHCVNTALQGPFFSEFDLAALAADLDQRERLVMLEGSRSPGAGNAAAGDFFAEGEGSHNVSLGGDFSIQVLQKALEVWDLQVIPLDSPAAGSSLFDPEQEVAFICHLQDHWFCMRKVNGEWYNFNSLYPAPEHLSKFYLSAFIDTLKGSGWSIFAVRGNFPKECPMATEGSNGFGQWFTPDDARRITASCNQVQTPPTEQVQSPLLAEQPEGMSEMDMIAAQQEEADLNAAIAASLMDTGVPFASYAAAREHSDSQDSPAREAAPSKDNNQEEAGKAEPSAPPCEEDIQELASGSDTRR... | 175 |
Q89X65 | 1.8.1.4 | ACT_SITE 445; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MATYDLVVIGTGPGGYVCAVRAAQLGMKVAVVEKNATLGGTCLNVGCMPSKALLHASEMFEEAAHSFAKMGVSVSEPKLELPAMMNFKQQGIDGNVKGVEFLMKKNKIDVLKGTGKILGTGKVEVSADGKSQVVETKSIVIATGSDIARLKGIEIDEKRIVSSTGALSLDKVPGKLLVVGAGVIGLELGSVWKRLGAEVVVVEFLDRIMPGMDGEIAKQFQRILEKQGFAFKLGAKVTAVDTSGKTLKATIEPAAGGAAETLEADVVLVCIGRVPYTDGLGLKEAGVALDNRGRVQIDPHFATSLKGVYAIGDVVAGPML... | 36 |
Q3K9H0 | 2.2.1.2 | ACT_SITE 125; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MTSKLEQLKQFTTVVADTGDFEAIARVKPVDATTNPSLLLKAAAIPAYAELLNASVRDCKGDVGLASDRFGVAVGQEILKVIPGRISTEVDARLSFDQDAVLKRAHRLIELYDKAGVGRDRVLIKIASTWEGIRAAEILEKEGIQTNLTLLFSFAQAAACADAGVFLISPFVGRIYDWYKKANGNDYTGADDPGVQSVTRIYNYYKANDYKTVVMGASFRNLSQIEQLAGCDRLTISPDLIEKLAADTGKLERKLAPGHAGEARLSLNEAQFRWLSNEDAMATEKLAEGIRQFARDQEKLEALLQAKL | 52 |
P74430 | 2.7.1.23 | ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MPKVGIIFNDDKPTACSVAQELQEQLQQSGFTVAMETGSGGLLGYSQPDRPICHTRIEHLTPPHFDESMPFAIVLGGDGTVLSAFRQLAPLGIPLLTINTGHMGFLTEIYLNQLPTAIEQLINGDYQIESRSMMTVRLMREENLLWEALSLNEMVLHREPLTSMCHFEIQVGYHASVDIAADGIIVSTPTGSTAYSLSAGGPVVTPDVPVFQLAPICPHSLASRALVFSDLEPVTIFPATPNRMVLVVDGNGGCYVLPEDRVHLSKSPYPAKFIRLQTPEFFRILREKLGWGLPHIAKPTSVELP | 89 |
P35125 | 3.4.19.12 | ACT_SITE 541; /note="Nucleophile"; ACT_SITE 1328; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLW... | 175 |
H2MKT0 | 2.3.2.26 | ACT_SITE 1478; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MRPSLATAVLPARTRSHNPPNLAVGGREHLSAPRRRSPHLRHTLSPDNLRTLAERGGAAVDPTSVVSSPVGLTRANSDTDLVSSQSRSSLTASTLEHTLNRGQNLVISWDIKEEVDATDWIGLYHIDETSPSNVWDCKNRGVNGTQKGQIVWRLEPGPYFMEPETKICFKYYHGVSGALRATTPCITVKNPAVLMEGLAEQVGIDHPRKLISFTLTDLCATGLKKGMFFNPDPYLKMSIHPGKRSIFPVFSHHGQERRSAIIANTTNPVWHGEKYTFVALMTDILYIEVKDKFAKSRPIIKRFLGQLTIPVQRLIEKIPG... | 65 |
A0A2G2Y4W5 | 2.3.1.48 | ACT_SITE 401; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MGTIKFETQSGTKTISDVLYVPDLDQNLLSVERGFHELCVEPPLLKEDIPPDDEGWLCPSFDCKVDCIDLLNDLQGTDLSVTDSWEKVYPKEDAATLSEEMAETPPKDDGILELSSEDSEDDDFNPDNPDKDESVKTESSSSDFTSYSEDFTLIVDTEFNRRLDEWVKLEHLDLNSVYTIMDEKVEDKVISFKISCHQKHKIDEIRVEDHEELDAASLREHEEFTKVKNIATIEFGIYEIETWYFSPFPPEYNNCSKLFFCEFCLNFMKSKEPLQRHMRKCDLKHPPGEEICRSGTLSVFEVDGKKNKVYGQNICYWAKL... | 61 |
A0A061G1L9 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIKMSPRKLTRVFTILAVVLFCQSVHSQLQIGFYRDTCSLVEFIVKEEVTKAFIKENGVVAGLMRMHFHDCFVRGCDGSVLLDSTPSSTAEKDSFANNPSLRGYEVIDNAKARLEAVCKGVVSCADIVAFAARDSIEITGGLGYDVPAGRRDGRTSLASEIIGNLPPPTFNVSQLTQMFAKKGFTQEEMVTLSGGHTIGRSHCTSFSNRLYNFSGTGMQDPSLDPRYAAMLKQQCPQGNKDTNLVVPMNPSSPSITDAGYYVDILANRGLFTSDHTLLTNPATANQVTQNARNPMQWRAKFGAAMVKMGQLEVLTGTAGE... | 14 |
A0A3B6AQZ9 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MHPCITYSHSHHMQHRRHNMRTSMYSVLLLQLVLAGAIARRVVVVEALDVGYYAATCPDAAATVRQAMELQFYNDRTIAPAIIRMLFHDCFVRGCDASVMIVSTARRSSERVAIPNQTLRGFNIVNRVKKALESACPGAVSCADALALMARDSVVLLGGAAYDVPLGRRDGLQSNPWEVDLPAPFARLDDALGAFAARGFSAEETVVLFGGHTVGATRCSHFRYRLAHPDGTMDEALRRGMADACGLAGGDLPPDADPTAFLDPETPFAIDNACYGQMMGNRSLLQLDQEAATHPATAGHVAYYAASPDAFVRRFSEAMA... | 14 |
A0D383 | 2.3.2.26 | ACT_SITE 443; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MGNRSSNNQHSKIGQEAKCPNCDRKFGPSTTYFVLNSHIDHCLLLQQPIHNVEFQMPQTQDQLGDNYIWVKQNNQWKRIQSQVNGGQIYVRTFYQFYQNLSAQEIKNRSFPEKQMWFNLQLEKFRIPWQLGSDKLNVNLNDLLQTSLVSARSVNFYKEVKVVFLNDKVQDAGGLLREWLTLIFKEMCKDIFTLTETNDVTYKIAKQSQYFDLAGLAIAKALFERMTICVEFDRPLVKKLLGQEISFQDMQCYDKSLFLSWKYLLENQFDENQLQQYFIICKDDEIIELKQNGADILVTNQNKQEFVDLSIQFYSEKLISK... | 65 |
A0A1U8FSY0 | 5.1.3.3 | ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 321; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MSSKVISLLICFFILHLLAAGRVSGCDIGIYELKKGDFSVKITNYGARIISVFLPDKNGKINDVVLGYDTIKEYVNETRYFGALLGRVVNRIGGAQFTLNGTVYKLVPNEGNNTIHGGPKGFSFVVWKVSEYVKDGPCPHLTLTYHSADGEEGFPGDVLVSVTFALKDPYKLSVEFKAKALNKATPISLSHHPYWNLGGHNSGNVLSQVVQIYASHITPVDEQLIPTGEIAPVKNTPYDFLKPLKVGSRIDKIKIGYDRNYVLDSNKKMKPVAVVYDKKSGRVMDIHATAPCVHFYTANWIVNVKGKGGYVYQPRSALSL... | 211 |
A0A061F8R2 | 3.4.19.9 | ACT_SITE 196; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 309; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 309; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MPSLFLSNPSSPSSSSDTPNDAVPSPSASSSSSSDMWNYLIVPILFYLSKDLSLAKAETSTPLLLPSQRRDNSSAETLSSASSCTTLDPKLYYRPVIGILSHPGDGASGRLNNDTNASYIAASYVKFVEAAGARVIPLIYNEPEEILFEKLELVNGVLFTGGWAKAGLYYEIAQKIFKKVLEKNDARDHFPLYAICLGFELLTMIISEDRNILESFSAADQASSLQFVKNINIEGTVFQRFPPDLLKKLGADCLVMQNHHYGISPERLRNNPNLSSFFKILTTSTDDNNEVYVSTVQAHGYPVTAFQWHPEKNAFEWGST... | 176 |
A0A2K1JZB6 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRWASTGFLAIFITIAIAIAIVMNLIIPAGAHKGLEVGFYRNSCPEVETIVYKSMAQSYKTNMTVAPGVLRLAFHDCFVRGCDAFVLLDGPNTERKSVLNGGLHGYDAVDAAKRATEKACPGIVSAPDVLQFAARDSVILANWRLPMERARWASRRDDFPHHGGNGCEPRPSEHDPVSTRSKVPGEGLERSLMVVLSGFHTIGKAPCLTFDDRVQTNPVDPTLAPSFAASLKKQCLYAQITSTKVALDSTPRRFDTQYFKDIIQGRGVLISDQELLYDSRTVGVVRANKGSAFYRNFGEAMVAMSELGVLTDGSGEIRR... | 14 |
A9VB34 | 1.1.1.205 | ACT_SITE 347; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 444; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MEFKTVPHDGRASEASLKGSQLITGHMGYVPEDGKSAAQMLSDGGLTYDDFLILPGFIDFVPDDVSLRSPLTRNISLNAPLVSSPMDTVTEHEMAIAMALMGGIGILHHNCDAERQAEMVRMVKKYKQGFIMDPVVLSPEDSVERVMEIKANRGFGGIPITATGKVGGKLLGIVTSRDIDYLNAESYATPVSEVMTPAERLMVGNTEMSLDDANAVMQDARKGKLPIVNDDFELVALISRSDLKKSREYPDSSKDAKGQLLVGAAIGTREHDRERLRLLVEAGVDVVVLDSSQGNSVFQIGMIRFIKDNFPQVDVIAGNV... | 3 |
W1PFN6 | 2.1.1.37 | ACT_SITE 1222; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MDTAVKRQKPTKATTTTNNYNKKRTADAPPERNSTSDIENPSRRRLPKRAASCSNFKEREKPLRLNQDDYILPKVQQTIADDEQTAIQLTRKGDEEEEQTPQRRLMDFIIHDSDGTPQPFEMSEVQDLYISALILPAGPTSSTDKNCGACCEGFGRIESWSISGYDEGKPLIWVSTDLAEYSLLKPSSQYKKHFDIFSDKALLSVEVFKKLSKFHGGYPLIGLDELLASLARALGSRKGGLTRDFIISQGEFVANQLYGLDSTSSNNDQVFAGLPVLTSWRNECQMREPSCRLTKVKDGSLKIGNGLASSASSSPDVMED... | 47 |
I1L0X1 | 3.1.1.11 | ACT_SITE 424; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGGHNNDHEQQRSFAIFIISSILLVATMPVAMAFGLNPNPVGLNTNPNPNPNPGGETNGETGHQSNVLSTHSSGITICQGTEYEEKCKQSLGNSLFVNTDPKKLIETQFKVAIGELVDNIINNSTLYKQIVTDERTRLAMDDCKEILGYAVDAIMKSTSLLIQFDFSKLMEIVYDLKVWLTGSISHQYTCLEGLKNIEEKASQKMAMAMSSSLELSSNALDMTDTISRMLNGFRPKIFNRRLLSEEATVVDGFLSWVNEGQRRFLQVALGSVKPNAVVAQDGSGQFKTLTEALKTVPANNDKPFVIQVKAGVYKEIVKVT... | 125 |
A0A3B3HN04 | 3.1.4.11 | ACT_SITE 331; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 378; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MASAQPGVHALKLQPPSVSHTLRNGSNFIKWDEDLSTVTPVTLHVDPNGFYLYWTDQNKDTELLDLTVVKDVRTGRSTKTTKEAKLRELLDVGNLVGRLENRMVTVVTASDLVNVNQLNFIASQEDEAKVWCEELFSLSSNLLSHNLNRDQSLLKAYVRLTLQLNTDGRIPVKNIVRLFSSDRKRVETALDSCRLPYGRGDSIRVEDFTLEVYKSFLDSLCPRPELGNIFKLQGGNGGMLSIDQMTEFINNKQRDPRLNEILYPPFRPAQTLSLMERHQLDQAELKRGLISLQAFSMYLSSDENGVIPPEKLDQSEDMSF... | 153 |
A8X4H1 | 2.7.12.1 | ACT_SITE 495; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNSGEKQDNLQAWGQQPSSSYSNTQQQHGQITGQIPLTITNQVEAHDNDFHMQDASNDELEKSKKIAEQPTEHPQQHHQQQPAVPRFPPQSRQPQAILRFPQPPITSINKANNSNSQNFFPQQEVLQSRPKKHRVSMTNAEAANTPGMPPEKLPAKKLSADSQRPLFRDSNVFQRSAGQFTNDNGPSSSSAIVGAPFDANSSSKPVHIQQFRNPNDAPVTKLTSDLIKTYKAINEKFQSFYLRKNVRRSTVGRHTSLDSSGKPKTGKEASSSDANLIETFSIHNAVPNTSSSGNQPHYDSHVNAPPLLDTNAPPTSTMVV... | 107 |
Q84JF0 | 2.7.1.25 | ACT_SITE 190; /note="Phosphoserine intermediate"; /evidence="ECO:0000250" | MDVAAMARCVGRCYVSPAFGESESHRLSERRFLKLSSSTNSDPAGSKSLKLRGKIHRRMSYFRPIMAKDESISSRSGETKQINGKQKNIVWHDCPVTKSDRQELIKQKGCVIWITGLSGSGKSSLACALSRALHNRGKLSYILDGDNVRHGLNSDLSFEADDRAENIRRVGEVAKLFADSGIICIASLISPYRIERAACRALLPQGDFIEVFMDVPLHVCEARDPKGLYKRARAGKIKGFTGVDDPYEAPLDCEIVIQNSRDKGLSSSSSSSSSPSSSSSSLCEMADIVVSYLDQNGYLKKHSTKSRNCM | 90 |
B7PMD4 | 2.3.2.26 | ACT_SITE 753; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | VPACEEQESWLVHAGGMVCVCALASLLVGVASMMPAPSGILCEQSAKLGFLGYLTGKYLSPASCKVDFDWQEPQEVGSTVTFTVKFFQRNGRAYPICNEDPLLVEVVAGGGHKVACDVQLGGAHPSEANQARVQFTVRRAGPCSVSVLLGMVHVRGSPFLKNFLPGHVQDELVTFMKQENYPKGFVYSAMYGTPDAQQWNHSQAACRRLANLWPFICEPSIFHWPVLGQCIPAAFISAFDRWPSGDRSSVRIRPIDGRILAVFSYHGTSLSNGDFHVIVLSNDMALVQKNVAKKSHNIWYEAKLIAFNSEKLLKPKTVFV... | 65 |
A0A9R1VHH4 | 3.1.1.11 | ACT_SITE 371; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MALLRCFGGTKLVLLLVLVSTLCYHPTPTFAAYSEGVYVDAECLKVPGSAFVGSVTSTIQTVREVISIVSKFSGAFGGDFRLSNAIADCLDLLDFSADELTWTLSTTQNPATGKYYNSTGNKGADMRTWLGGALGNQDTCMDGFEGTNSFVKTVIGGSLQQVTSLVRDIIGMIREVPLTNADHVVPSGRRKLRGVDGPVFPGWLKAKDRKLLQANGSNIEADVVVAADGSGNFTKVMDAIDAVPDHNNRRYVIYVKKGVYHEYVEIGKKKTNIMMIGDGKDLTVITGNHSFIDGWTTYRSATFAVKGQGFIARDMRFENT... | 125 |
A0A251TE90 | 3.1.1.11 | ACT_SITE 201; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MIKSESCFVINILLLITIMFLLDGVNCRSFLTLRPPIEDDVTPKIVTRKMITVDVKGSEKFTSIQDAIDSVPDGNQDWVLIHVKKGTYREKVRIPREKGHIFLRGSGRTKTVIVWSQSCENNYESSTFKVDADDFIAFGISFKNDAPTGIANTSHNQSVAAYVGGDKAAFYSCGFYSSHNTLLDNEGRHYYDRCYIQGAIDIIFGQARSVFHECEIFVIADQRIEIQGSVTAHTRTSANENTGFVFLKGRIYGIGHAFLGRPKGDHSRVVFAKTYLSKSIIPQGWSDWNHHGSLEHVYHAEYNCHGPGSSTAGRAPWLKK... | 125 |
Q83AP0 | 3.1.1.29 | ACT_SITE 23; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MSGGVKLIAGLGNPGDQYARTRHNVGAWFLETLAQQRNQSLAKENKFHGFVAKCNDYWLLKPTTFMNESGQAVAALAHFYKIKPSEILIAHDELDFPAGDIRLKEGGGHGGHNGLRNIIQHLGSSDFYRLRIGINHPGHKDRVTPYVLSPPSENDRIAILAAIEKGLRLIPELVQGDFQKVMRELHS | 127 |
Q83AQ1 | 2.7.6.1 | ACT_SITE 198; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MPNVDDIRIFHGSANPSLAENVAKELNTTIGNALISRFSDGEIRFEIEENVRGRDIYLIQSTGHPTNEHVMELILMGDAFRRASAASITAVVPYFGYARQDRRVRSSRVPISAKVVADMMQKVGFSRLITVDLHADQIQGFFYMPVDNIYASITALEEYRLLDKLETPMIVSPDVGGVVRARAIAKRLNDSDLAIIDKRRPAPNQAEVMNVIGNVQNRHCVIVDDIVDTAGTLCHAASALKEKGALTVSSYCTHPVLSGNAVKNIMDSDIDELIVTDTIPLHEEAAKCRKITQISLSRLIAETISRINQKESVSSMFLD | 114 |
A0A7M7PP31 | 2.1.1.37 | ACT_SITE 1224; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MPSKTLCDRVIPTNVRNRVQELEGDLNDGLITEKGYIKKKSKMLFEHMSSDMQTTLKGLEDELKDEELTEKGYVNKVKSILAKFLDTCTPISNGDIQQENSSKKKLNKDTQSTVKNGSSSISSNGSGDPCKANGHSNGSHVRASDQEGNGSSQSEERMETDTPTSGKGDSKKKKKKGSPGGSEGGKGSKRKVLGDSDREEEEKKGREENKEVEEEEKEEESAGKTTPDANTPRSSKRKRSPKVDAKQPSIMSMFTKKPAKKEEEKVEESLSSVDENETKMENGDDGKKEEEEEEPSGPGGKRIKKEEEEEEKANDEPMSP... | 47 |
A0A059BYW3 | 1.11.1.7 | ACT_SITE 86; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLIMLRTKRRSSSSNVVATAIIAVLVLLVMHVMGSSESEGQEQQQLRVGFYSKSCPPAESIVHAVVKEAVLSVPRNAAVLLRIHFHDCFVEGCDGSILIDNGDISERHAGAHAGVGGFEIIEAAKARLESTCPGVVSCSDIVAMAARDAVFLSNGLFYEVQTGRRDGRVSNWTLAADMPDVNDSIHMLKAKFRQKGLKDKDLVLLSAAHTIGTTACFFMGTRLYQFNSTGGSDPAINPRFLPVLKSICPPGGDVNVRLALDAATEFVFDDLILHNIKNGFAVISSDARLYDSRHTRRIVDLYTQNGTSYKHEKPPSFKVD... | 14 |
A0A139WJG1 | 3.1.4.11 | ACT_SITE 327; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 374; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MTKKFEFDWHVPVPEPLLTGCVVDRWSEEPNEIEWKALFRVDEYGFFIYWKSEGKEGDVIELCQVSDVRAGGLPKDLKLFSQLESRHGPDLEKRSLTICSGTDYININYQHIVCPNAETAKVWLDGLRKITHNVKANNFCPMTCLKKHWMRLGFLTDAKGKVPVKVVARTFASGKSTEKLVYQCLADLDLPNGKNAVMEPEQFTFEKFYTLYHKICPRNDIEELFRSITQGKADYMNLEQFINFLNEKQRDPRLNEILYPHYDAKRASEIIATYEQDEEAKAANRLTKDGLIRYLMSDENAPVFLDRLDIYMDMDQPLCA... | 153 |
A0A3B6FPE6 | 3.1.1.11 | ACT_SITE 485; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLYLLTFLPLQTIPCLLLRQGRLLAYLRQQCLHNIYARTTNGHAHTLLTAMTSTWMARGKGTPLQVLLLLLALLIVPRGGDGAAVFSGYTFKGQGEAEAFEEALLRQACFNVTSSSSGAGRGKGDCVSRIDTARGGPSSGPVPVLRAALRDTLGEAVSAVGAVAGLASLSNHAREEMAVRDCIELLGYSVDELGWSLDAMAESLDGVEPEMETQHGAASGSVRSGARAEDDLHAWLSAALGNQDTCTEGFRGTDGRLLRRVEASVAQLTQLVSNLLAMHKRLRSIMPLRQHGKNDTAASGAGSELPPWVMDVAGGVEGEL... | 125 |
Q9X255 | 2.7.1.23 | ACT_SITE 51; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MKIAILYREEREKEGEFLKEKISKEHEVIEFGEANAPGRVTADLIVVVGGDGTVLKAAKKAADGTPMVGFKAGRLGFLTSYTLDEIDRFLEDLRNWNFREETRWFIQIESELGNHLALNDVTLERDLSGKMVEIEVEVEHHSSMWFFADGVVISTPTGSTAYSLSIGGPIIFPECEVLEISPIAPQFFLTRSVVIPSNFKVVVESQRDINMLVDGVLTGKTKRIEVKKSRRYVRILRPPEYDYVTVIRDKLGYGRRIE | 89 |
Q9DGJ4 | 4.1.1.17 | ACT_SITE 361; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MTACTGSDFDFAFLEEGFCARDIVEQKINESSLSDDKDAFYVADLGDVLKKHLRWLRVLPRITPFYAVKCNDSRAVVTTLASLGAGFDCASKTEIQIVQSVGVDPSRIIYANPCKQVSQIKYASAHGVQMMTFDSEVELMKVARSHENAKLVLRIATDDSKAVCRLSVKFGATLKSSRLLLERAKELGLDVIGVSFHVGSGCTDPETYSQAISDARYVFDIGAELGYNMSLLDIGGGFPGSEDTKLKFEEIAAVINPALDKYFPVDSGVRIIAEPGRYYVASAYTLAVNIIAKKVIMKEQSASDEEEDVSNDRTLMYYVN... | 195 |
P75392 | 2.3.1.12 | ACT_SITE 374; /evidence="ECO:0000255" | MANEFKFTDVGEGLHEGKVTEILKKVGDTIKVDEALFVVETDKVTTELPSPYAGVITAITTNVGDVVHIGQVMAVIDDGAGAAAPAAPQPVSAPAPAPTPTFTPTPAPVTTEPVVEEAGASVVGEIKVSNSVFPIFGVQPSAPQPTPAPVVQPTSAPTPTPAPASAAAPSGEETIAITTMRKAIAEAMVKSHENIPATILTFYVNATKLKQYRESVNGLALSKYNMKISFFAFFVKAIVNALKKFPVFNGRYDKERNLIVLNKDVNVGIAVDTPDGLIVPNIKQAQTKSVVDIAKDIVDLANRARSKQIKLPDLSKGTIS... | 54 |
A0A803TIU3 | 2.7.10.1 | ACT_SITE 700; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | TYPSHGWDSINEMDEFFNPIHTYQVCNVMSPNQNNWLRTSWVQRHGAHRVYAEIRFTLRDCNSMPGVLGTCKETFNLYYLQSDRDLGSAPRESQFVKIDTIAADESFTNVDLGVRRLKLNTEVRGVGPLTKRGFYLAFQDIGACIAVVSVRVYYKKCPAMVRNLASFSEAITGADSSSLVEVRGECVRNAEERDTPKMYCSAEGEWLVPIGKCVCSAGYEELRDSCRACQVGSYKSSPGDQLCAKCPPHSYSETPAAQVCRCETGFYRAALDLPSVACTRPPSAPMGLLSSVNGTSVTLDWAPPQDKGGRSDVIYNVICR... | 97 |
P30290 | 2.7.11.1 | ACT_SITE 417; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDSSTTIPITPTRTPCFFNISSSFNEHSPLNFYDEPIYNFSSGHEENQSHKSSKLTFFKPSNTKRSPHTPMQNNAKAIRLSTTVRHGIFKNSDLDGCSKPFAFSSGLKLSKKIVDASTPIDLKRKRAVTSLSTGLLSKREKWSLWEGNLTNPRSEQPHTPCKKGTKIKLKPPQSPLSPTTSLLARKCKHIDLDTFSRLDHPNSDSSDETFEMEELPSLSYGSEDLLEFCETPCKSQPIFLSSSHVNNWDEKDVPSSLSWTPTSPIFLNINSADDYEEEEDWTSDLRIRFQQVKPIHESDFSFVYHVSSINPPTETVYVVK... | 99 |
Q0V6A5 | 3.5.1.98 | ACT_SITE 196; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MGFPGVPPPNPRNNIVEEYLSPDDAYYVEDYSAFKRLSDEEKVEVVAREAQDNGMEKPLGWNVSFHYNPHVEYHHFGSSHPMKPWRLTLTKQLVVAYGLEYTMDLYTPRPANFGELALFHDREYLEYLSKITPQNAQPEDPQYISYGFGGDSNDCPVFDGLWNYVSLYSGASMSAAWNLLNKQSDIAINWSGGLHHAKKNLASGFCYVNDIVIAIQLLLTQHQRVLYIDIDVHHGDGVEQAFESTDRVFTLSYHKYGIDRHGYPFFPGTGNINETGPHDPINRGKGHSLNIPIDDGIDDAQYKHLFSTITSAVVEKYNPQ... | 184 |
Q5BD29 | 3.2.1.21 | ACT_SITE 392; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 488; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MRGAILATAAAFAGTAVADMHMRRHAHEGLHHRALHASSAVPEEECGCTTEVITYWGEPTTIPLSVPTSTVTSETTETVHSTSYSTVTVTATSSAAPVETPSETPSPTPEVTLPTAGVTSYSETGTYTIPATTITVTDTTTVCGATTTELPSGTHTYGGVTTIVETATTITCPYATVKPTGSTVTSVIETTTYVCPSAGTYTIAPTTTFVPTSTVVVYPTPETVTPGTYTNPGTTITVTRTEDVYVCPYTNGNVPTSVPALPTTSAASTTTAVPSSSTTTSSATSVPTGASGNKMGMTFTPYNNDGSCMAKNDVLEQVGL... | 161 |
B6JY65 | 6.2.1.5 | ACT_SITE 271; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1" | MSLVLKRFASSSAYRSTIKNLMISSSTKVLFQGFTGKQGTFHAQQAIDYGTQVVGGTNPKKAGTTHLGRPVFADIAEAMKETKADASAIFVPPAFAAGAIAEAIEAEVPLVVAITEGIPQHDMLRISDMLKTQSKTRLVGPNCPGVIRPGQCKIGIMPSHIHMPGRIGIISRSGTLTYEAVNQTTQTKLGQSLVIGIGGDPFPGTNFIDGLELFLNDPNTDGVIMIGEIGGSAEEEAAEYLKNHNLTREKPKPVVSFIAGVTAPPGRRMGHAGAIVAGGKGGAMDKLLALEAAGVRTARSPAILGKLICEELAKQ | 247 |
P07635 | 3.2.1.26 | ACT_SITE 42; /evidence="ECO:0000255|PROSITE-ProRule:PRU10067" | MLLQAFIFLLAGFAAKISALMTNETSDRPLVHFTPNKGWMNDPNGLWYDAKEGKWHLYFQYNPNDTVWGLPLFWVNMTTGVDNLFYIDKFQVREVK | 164 |
Q9T053 | 3.1.4.4 | ACT_SITE 369; /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"; ACT_SITE 371; /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"; ACT_SITE 376; /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"; ACT_SITE 709; /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"; ACT_SITE 711; /evidence="ECO:0000255|PROSITE-ProRule:PRU00153"; ... | MAYHPAYTETMSMGGGSSHGGGQQYVPFATSSGSLRVELLHGNLDIWVKEAKHLPNMDGFHNRLGGMLSGLGRKKVEGEKSSKITSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDSDIIGSQIMGAVGIPTEQLCSGNRIEGLFPILNSSGKPCKQGAVLGLSIQYTPMERMRLYQMGVGSGNECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRQARRLIYITGWSVFHPVRLVRRTNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSRSLLGFK... | 155 |
Q602L8 | 2.2.1.2 | ACT_SITE 136; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MSKNLLDQLREVTVVVADTGDIEAIEKFKPRDATTNPSLITAAAQMPQYQDIVDDTLKGARQTLGPGASAAQVANRAFDRLAVSFGLKILQIIEGRVSTEVDARLSYDTEGTIEKAREIIKQYEAAGVSKERVLIKIAATWEGIEAAAVLEKEGIHCNLTLLFGLHQAIACAENGITLISPFVGRILDWYKKDTGRESYAPHEDPGVLSVTQIYNYYKKFGYKTEVMGASFRNIGEITELAGCDLLTIAPSLLAELQATEGELPRKLDPAKAKDYPIEKIHVNKYTFDKMHAENRMATEKLEEGIQGFTKALEQLEKLLA... | 52 |
K3Y935 | 3.1.3.48 | ACT_SITE 111; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MPHLVRERLYFGDIKDAIAALTDSSSTPTFTHVLSVVSSASISFITDCRPGLAIPTEEVRRVVAGEEGAPPTAAVPPGTLMRVEENLLDHLEPCLDFIDDGRKVGNVLVHCFAGVSMRSEQKPLEEALESLKEISELACPNDGFLEQLKLFGEMGFKVDTSSPLYKRFRLKLLDPSKTEQHKTAYRCRKCRRIIAVEDNVISHVPGEGESCFDWNRRKSGHSYSNKEQDCSSLFIEPLKWMTPVKEGALEGKLSCIHCGARLGYYPNWSGIQCNCGSWVTPAFQIVKSKVDISTI | 149 |
G7KUL2 | 3.1.1.11 | ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKTKTLLVSSFFLILIINITFGIVHSDNFNEFRIPNKVVKSLCKDTDDHKLCHDVLYPVKTSNPIDYIDVVVKNLMESVENAFNDMSNKLSSMENNESNNLGIKMALEDCKDMLQFAINELKASKVIITESSSIRSIHNRSVELKNLFGAVIAYQQSCLDGFSDTKSDNNKAMLHLQTDNYLDNVGKLTGLALDVVSEISHSTNVKSLVDNEGYPTWFSVDDRKLMAMGPIGATDNDVLVTVAKDGSGQYKTIVDAINAYPNNHQGRYIIYTKSGVYDEYIFVDKDKPNVFMFGDGPTKTIITGSKSFLQGIKTMRTATF... | 125 |
B5YI38 | 3.4.21.92 | ACT_SITE 98; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 123; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MSIVPIVIEQTGRTERVYDIYSRLLKDRIIFIGTEINDHVANVVIAQLLFLQTEDPEKDIHIYINSPGGMVSSGLAIYDTMQYVKPDIATYCIGQASSMACVLLAAGTKGKRFALPHSRVMIHQPIGGFYGQATDVEIHAKEILKMKDLLNNILAKHTGQPIEKIQKDTERDFFMSAEEAKLYGIVDEVISSIKK | 179 |
Q0V6B1 | 3.1.3.1 | ACT_SITE 141; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MARPLLANRASSDISGDRDIAEEDALLTGQPTQRAASGPRTWKFWREVGLFVWAVVATAGIIVLAVVFQKHSDTQNGSANPSGKRNLIFMVSDGMGPTSLSLTRSFMQFQNGLPFGEQLVIDKHLIGQSRTRSSSSLITDSAAGATAFSCGKKSYNGAISVTPDHEPCGTVLEAAKKAGYMTGLVVTTRITDATPACFAAHVNMRQEEDLIAQQMVGDYPLGRVVDLMFGGGRCHFLPNSTAEHSCRADDKDVVALAKKNGYSYVDDRAGFDSLKGGAGLKLPMLGLFADTDIPYEIDRRNENDIYPSLQEMAETAMKAL... | 141 |
A0A804JQJ9 | 2.1.1.37 | ACT_SITE 1208; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MTKDLTGFSGIKRKVRGRPSKKKEKITNDSSTEQEAVASFIEDLGNNLENGEELVTRKRPKRAAACSNFKEKHIKLSDGSLLVEIKKNQVEKDEIVAVQMTKLGPDDIPPCRKLVDCILHDADGNMQPFEMSEIDDIFITAVVMPLDDNLEKVKERGIKCEGFGRIESWSISGYDDGSPVIWLSTNSADYECVKPASIYRKFYDLFHEKACICVEIYRKLARSVGGNPDLSLEELLAAVLRSVGGTKSFSSGLTSRDFVISLGDFVYNQLVGLDETSGNNDVQLATLPTLVALRDKCRRRTAFNKSSNIPNGSLKIKEGD... | 47 |
A0A3B6PKG8 | 3.5.1.98 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MAASGEGASLPSPAGGEDSRRRRVSYFYEPTIGDYYYGQGHPMKPHRIRMAHSLVIHYGLHRLLELSRPFPASEADISRFHSDEYVSFLASATGNPTILDPRAVKRFNVGEDCPVFDGLFPFCQASAGGSIGAAVKLNRGDADITVNWAGGLHHAKKGEASGFCYVNDIVLAILELLKFHRRVLYVDIDVHHGDGVEEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAGEGKHYAVNVPLSDGIDDDTFRDLFQCIIKRVMEVYQPEVVVLQCGADSLAGDRLGCFNLSVKGHADCLRFLRSFNIPMMVLGGGGYTIRN... | 184 |
Q86IA3 | 5.3.4.1 | ACT_SITE 51; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 54; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 172; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 175; /note="Nucleophile"; /evidence="ECO:0000250" | MKILLFVTLIALAFVALCSAEGNVVVLSPDNFDTVVDGSKTVFVKFYAPWCGHCKKLAPDFEILADTFAPVSNKVVIAKVDCDQADNKALCSKYDVSGYPTLKIFDKSTTAKDYNGARSVDELLTYINNHAKTNVKVKKAPSNVVDLSPSNFDSVVLDKSKNVLVEFYAPWCGHCKKLMPDYEILGNTYANEKDVVIAKIDCDAADNKAICSKYGVTGFPTLKWFGKQSKDGEKYEQGRDLDTFINYINKQAGVNRVKGGKLAVGAGRVEQLDTIATEFIAAAAEVRKELVKKAQTVVDSLPEELRTEGSYYVKVMKTIA... | 215 |
A0A804QMF0 | 1.11.1.7 | ACT_SITE 21; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVRALSVAPSLAGPLLRMHFHDCFVRGCDGSVLLDSTANNTAEKDAKPNLTLRGFGFIERVKTAVEKACSDTVSCADVLALMARDAVWPVRTYYVHTHQSMHIRTRTYVIMRISSYWLAVCSHSLRARARSGRSRWGGGTAGCPSPTRPTSCRRPRATSRSWPSFSAPRAWTPGTWRCCRPATPSARRRIASPSRTASTTSRAWTTPATPTRSWTGRTWRASAPSAPAWTTTPRWWRWTPAASGPSTWATTPTWPSAGASSTPTPSCSPTLPPAPTCSATPRVPTGTSSSPTSPRPWSRWAPSACSPAARARSGRSATSS... | 14 |
A0A1U8JST1 | 3.2.1.14 | ACT_SITE 145; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MRAPALSFCANALPGSAMQCEKQPCSATAMFPTAQWCCRGANNDNYRHKKIGLRSNCNKGDAGCGCGCGGGSDGGGGGGLSSIVTREVFEEMLPYRNDPRCPAAGFYTYETLMAAAKAYPAFAATGDDATRKREVAAFFGQTSHETAAARGRNPPGGPFGWGYCYNKEVKPLSEYCDGTNQRFPCVPGQKYYGRGPIQLTWNYNYGQFGAAIGKEKEMLENPDLLLTDASLAFHSALWFWMTPQRSMPSCHDVIVGAWMPSARDKAAGRFPGYGVITNIINGGQCGRGRNAAGEDRIGFYKRYCDMFGVNCGDCLDCYNQ... | 158 |
Q83BZ5 | 1.1.1.205 | ACT_SITE 303; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 401; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1" | MRVKEEALTFDDVLLLPNYSEVLPKDVSLTTRLTREITLNIPLLSAAMDTVTEARLAIALAEAGGIGILHKNMSPTYQANEVRKVKKFESGVVFDPITVSPESTIGELKKITSEYNISGLPVVEGEQLIGIITSRDIRFETDMQQKVVNLMTPKDRLITIKEGASRDEIINLFRQHRVEKLLVINDRFELRGLITVKDILRSERNPNACKTKSGQLRVGAAVGTGGETPDRVTALAAGGVDVIVVDTAHGHSKGVIEQVKWIKKNYPHIPVIAGNIATASAARALADAGVDAVKVGMGPGSICITRVVAGIGVPQITAIN... | 3 |
Q2FY03 | 2.7.1.107 | ACT_SITE 59; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600829-1" | MKRFKYALDGLKILIQKDYKFLLHVFAMIVAIVFGLVLNINRIEWIFILIAIALVLTVEALNTAIEYVVDLVTVEYHDLAKYAKDIAAFSVLIVSILAFIIGLIVFLPHFIALF | 83 |
T1EEX3 | 3.1.4.11 | ACT_SITE 327; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 374; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MAKIVDFQWQIPIPDVLLLGEYFDRWEEEIGVYEAGCMVKVDEFGFFIHWKSDGREGQVIECSQVSDVRAGPAPKDTKIASELESHGVGTLEQRTITVCSGLDLVNITYNNFVAANSKIANEWIEGLKKVTHNLKANNVCPMTCLKKHWMKLGFMVNTNGKIPVRSVSRTFASGRTERLIMQSLKDLGFPSGKNDEIEMDSFTFEKFYELYHKICPRTDIEDLFKDMYVAGNSKTLASSQFIEFLNNKQRDPRLNEILFPPFEKKRVLQIIDMYETDEKLKKQEVISLDGFCRYLMSDENAPVFLDRLDIYADMDQPLSH... | 153 |
P22517 | 2.7.11.17 | ACT_SITE 171; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPKESEVINSEFHVDVQDPERLNGHPVAKFINKLSGQPESYVNRTNYIFGRTLGAGSFGVVRQARKLSTNEDVAIKILLKKALQGNNVQLQMLYEELSILQKLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEYMHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLKGEEDLIYKAAGSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFIAESVEGFMEECTASRYPVTFHMPYWDNISIDVKRFILKALRLNPADRPTATELLDDPWITSKRVETSNIL... | 101 |
A0A2K3DLU8 | 2.1.1.37 | ACT_SITE 828; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MCNLQARSLLAGTRRAAYAAVLRASSQQVTRRRRNTQVPDLAEELALLAPRRAPEDIDMVTASLAAAKGPLVAVVRPVNQGDGQSEAPAAINAVEPTPGVKGRRSRRNPFQALLATLQPGVATAQVSAVWLSSLRAQLRASSTSTQVRQGHGSESAAKLTSTPTAGQDASSQQGWKLHGVSARLPLAAPDGDNTGGPTADPLGTLPLRTRTTYQSAVGPELVGTGQGKRQWLRPGDIIRVTLQQESGSKQQAGNEEVQAAASGSSSSPAATTYLVQALYRDKQYGVKYGEPMVQLRLLLHGRDTVLEDAAADHELFLLDT... | 47 |
A0A7M7RFJ6 | 2.3.2.31 | ACT_SITE 466; /evidence="ECO:0000256|PIRSR:PIRSR037880-1" | MRSISLRVAVLRASAQQAQFVFVFVCYYVIYEVLLCPSNMDRVLISVKLIQSQKLSKCAENATVMTVHINPSQNGGELRSEVARLSGQSPADIRLVFAGKLIDDVQIMEDLRICENTMIHAVPAQRIQCHSDGPKTIKDEGVKPQPVHVLMESRIIDEDQRSPETPDVDLASSLHPSFYVYCKSHCRSVQPGKLRVCCQTCKDNAFIVKEDPVCWDDVILSNRISGSCLVPGCQGQKAEFFFKCSSHASSVNDQFTVLPLVKTNTRRVICITCADILTSVLVFPCSASHVMCLDCFRQYCRLCLDERRFIQSPELGYTLP... | 67 |
I1KQ16 | 3.4.21.89 | ACT_SITE 131; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 181; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MPSLSVFPSLPSLQNPNLSQPNFFNFRLPSLCHRPLVKSTATFHRRILCKAFRDSGEDIKAVLKSDDGGGSGDGGGDGGGGGDRDAEKKEGPLPEWLNFSSDDAKTVLVALAISLAFRTFVAEPRYIPSLSMYPTFDVGDRIVAEKVSYYFRKPCASDIVIFKSPPVLQEVGYSDDDVFIKRVVAKAGDIVEVRKGHLVVNGVERNEEYILEPPAYEMKPTRVPENYVFVMGDNRNNSYDSHVWGPLPAKNIIGRSVFRYWPPNRIAGTVSKETCSVETTQTQESAETALPSQ | 178 |
Q9NWF9 | 2.3.2.27 | ACT_SITE 688; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MEEGNNNEEVIHLNNFHCHRGQEWINLRDGPITISDSSDEERIPMLVTPAPQQHEEEDLDDDVILTEDDSEDDYGEFLDLGPPGISEFTKPSGQTEREPKPGPSHNQAANDIVNPRSEQKVIILEEGSLLYTESDPLETQNQSSEDSETELLSNLGESAALADDQAIEEDCWLDHPYFQSLNQQPREITNQVVPQERQPEAELGRLLFQHEFPGPAFPRPEPQQGGISGPSSPQPAHPLGEFEDQQLASDDEEPGPAFPMQESQEPNLENIWGQEAAEVDQELVELLVKETEARFPDVANGFIEEIIHFKNYYDLNVLCN... | 66 |
P36615 | 2.7.11.22 | ACT_SITE 129; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MKSVGHFVPWLTDIRHLTDGTISEVFVGERKNSKKLYVIKVQGLVFKRPPHDAMRGKLILESIGHPHIERIVDSFIDNEAGSVYLITSFKSFVLSDVMDEISIDTKCKIVLQISSALEYLEKHGILHRDIHPNNILLDSMNGPAYLSDFSIAWSKQHPGEEVQELIPQIGTGHYRAIETLFGCHSYGHEVDRWTFGILIAELFSNQALFDDGSSEGWPSELRLTSSIIQTLGTPNPSMWPELSTFPDWNKFIFHEYPPKPWSEILPSVDTSIQYIVSHLVTYSNRASPSFVIESFPKVSARLSQYA | 102 |
A0A3B6HRM6 | 2.3.1.181 | ACT_SITE 181; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MGGGAARRVLEAWKLGVVKYGDALRLQERLVADRRAGRVPDLVLSLQHPPTYTLGKRRTDHNLLVPESSLAGLGAELYRTERGGDVTFHGPRQAVLYPILSLRDIGLGARRYVEGLESAMIEVASLYGVKARPGGACETGVWVGDRKIGAIGVRISSGFTCHGLAFNIDPDLGYFKHIVPCGIADKEVTSLRREAAVELPPDEVIHGQLVQSLATTFRFSDVKVKDDSECADMISSAATEQH | 55 |
A0A2K3CR84 | 6.3.4.4 | ACT_SITE 45; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 73; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 175; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MATSLMKSSLALHAAPRPRSVRLSATSSRVDSPQVSVVLGTQWGDEGKGKLVDNLAQQFDIVARAQGGANAGHTIYDETGRKFALHLVPSGILNPKATCVIGNGVVLHLPGLFEEIRRLKEKGVQVDGRLLVSDRAHLLFDLHKEIDGLREAELAGDGKQIGTTKRGIGPAYSSKATRNGLRVCDLFDRATFKTKLTNLAADGAKRFGEKFAYDVEGDIAAYEKLAEEIRPFVVDTVEYLHEALQSGKRILIEGANATMLDLDFGTYPYVTSSNPSIGGIATGLGLPPSSYDDIVGVAKAYTTRVGAGPYPTEIHGKLAE... | 253 |
A9U297 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARLGSFVAVLVLVCAASFVNVADSAGLVNNFYRKSCPNAEKIIRDSIYRMYEKKGNIATSFIRFGFHDFFNGADASFFLLSAPGKTSEKDSHSMVGMRNEKYVNNIKAEVEKVCPGVVSCADILAVGSAAAVQVLGGPYIHVKTGRKDTRNSMKSSADTIPRPQDGVTKVLTFYKNIGINPREAVALMGAHTIGRAHCTSFIERIFPKVDPKMDPVFAEKLKRRCPAKPTSVHFTYFRNDEPSPMAFDNNYFKNLVTKQGLMGIDSALYWDGRTQKYVIEFSQNEAAWREVFTVAFKKLSEYKVLTGRQGEIRKRCMYV... | 14 |
A5F4C4 | 1.3.3.3 | ACT_SITE 113; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MESIVDKQAVKHFLLQLQDKICQQLEATDGQAQFIEDAWQREPGEKLGGGGRTRVMREGAVFEQGGVNFSHVFGEQMPASATAHRPELAGRRFEAMGVSLVMHPKNPYVPTSHANVRFFIAEKEGEAPIWWFGGGFDLTPFYPFVEDGQHWHQTAKNICAPFGSEIYNEHKAWCDRYFYLPHRNETRGIGGLFFDDLNEWSFEQCFAYMQAVGEGYTQAYVPIVEKRKNTPFTERERQFQLYRRGRYVEFNLVLDRGTLFGLQTGGRTESILMSMPPLARWEYAYQPQAGTPEAKLSEFLVPREW | 27 |
A0A2C9V0Y1 | 3.2.1.14 | ACT_SITE 115; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MHLTHHLSLAFFRPISLKMVTQQRMMSHLFAITLAIILAGALPKNVMGQSVADLVTQDFFNGIINQAPAGCPGKNFYSRDTFLQALNSYSDFGKLGSPDDSKREVAAFFAHTTHETGFFCNIEEKDVPATENYCDTNFPQYPCTPGKRYFGRGPIQLSWNYNYGAAGQDNGFDGLNNPEIVATDPVVSFKTALWYWMKNVRPSVSQGFGATIRAINGPVECDGKEPAKVQARIDLYTRYCGQFGVAPGGNLQC | 158 |
P49814 | 1.1.1.37 | ACT_SITE 180; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00487" | MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPTKGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEKIMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTFVAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGGGEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIVGGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS | 5 |
P28072 | 3.4.25.1 | ACT_SITE 35; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:25599644, ECO:0000269|PubMed:27493187" | MAATLLAARGAGPAPAWGPEAFTPDWESREVSTGTTIMAVQFDGGVVLGADSRTTTGSYIANRVTDKLTPIHDRIFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVHTAASLFKEMCYRYREDLMAGIIIAGWDPQEGGQVYSVPMGGMMVRQSFAIGGSGSSYIYGYVDATYREGMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVERQVLLGDQIPKFAVATLPPA | 180 |
A0A8V0YCY4 | 2.7.11.1 | ACT_SITE 278; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MDRKTKENCPGNPSRATKVANPVVDGPKRVPVPQNSAQSRPLNSGVQPQRVLCPSNFAQRVPVQSQKSSLSNQKLSNNQTTQQPRPKLPVQPTAGPQVPSKSSEKPQQAPVPAKSSEADSVSKQKNEESTKKKKEETKKRQWSLDDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEDAGVEHQLRREVEIQSHLRRAFQFSCRHPNILRLYGYFHDVTRVYLILEYAPRGEVFKELQKLTKFDEQRTATYITELADALSYCHSKSVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRSTLCGTLDYLPP... | 99 |
Q8F6S8 | 1.8.1.4 | ACT_SITE 446; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MSAEFDVVVIGAGPGGYVCAIRCAQLGFKTAIIEKRKTLGGTCLNVGCIPSKALLDSSEEYHKTLHKLEVHGISVGKVDLDLNKLMNRKDQIVKEVTDGVDFLMNKNKIKRYEGFGKVLSAGKVEVAFNDGKKETLSAKHIVVATGSVPIDIPGLTVDGKNIITSDHAIDVRKLPKKMIIIGAGVIGLELGSVWGRLGTSVTVVEFLPGLISNVDRQMGSLLERSLTSQGMEFLFEHKVKGAATTKNGVKVQIEDSKGESKDLEADVVLVAVGRRPFLEGVGLEEAGVAFTQRKRIQVDAHFKTSVPGIYAIGDAIDGPM... | 36 |
A0A061EN86 | 1.11.1.7 | ACT_SITE 100; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVRIRITRYDQESSKAMRRGSRVLRTTKKMSPSAQMASLFTSLLFLLAIFFISPAVSLPLKIGFYQKTCPSAEAIVMSTVKAALASDPGIPAALIRLHFHDCFVRGCDASILLDSTPSNRAEKDSMGNKGVQGFQVIDEAKAKIEAQCPNTVSCSDILAFAARDSVTLAGGLHYGVPSGRGDGRVSSAAEVTQNLPDAFFNVTQLKQNFARKGLSMEEMVTLSGAHSIGDSHCSSFSKRLYSFDKTSTQDPSMDPSYARLLKAKCPRPLNTRTGPDPLVPFDPVTPNRLDNNYYKNLKSSKGLLASDQVLWNSMLTRKFV... | 14 |
Q83B44 | 4.2.1.11 | ACT_SITE 207; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 337; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MTATITDINAHEILDSRANPTLEVRVTLSSQAYGCAAVPSGASTGEREAVELRDNDLERYGGKGVLQAVENVNGPIRDALLGQDPRSQEEIDRIMIELDGTENKANLGANAILGVSLAVAYAAANNADLPLYRYLGGDGGPFSMPVPMMNIINGGAHATNNLDFQEFMIVPVGAPTFAEALRYGAEVFHALKKRLVSRGLMSAVGDEGGFAPDLPNNEAAFELILEAIEDANYVPGKDIYLALDAASSELYQNGRYDFENNQLTSEEMIDRLTEWTKKYPVISIEDGLSENDWAGWKLLTERLENKVQLVGDDIFVTNPD... | 200 |
Q10283 | 1.1.1.34 | ACT_SITE 712; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 846; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 922; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 1018; /note="Proton donor"; /evidence="ECO:0000255|PROSI... | MIYKLAARYPIQVIAIVGILVSMAYFSFLEALTQEDFPVLIRALKRFGILDGFPNTRLPNEMILKLSSVQGEDASVWEQIPAAELGGEGFVDFDITQWYYPANAKVDVAQLVEPYRNDCIFHDASGACHFFFKEVGNWTVSSIALPSNLANPPIDYFLDSSSTVIQRILPAIREHGISWSWLLQLIARTWMNTLKIASQASKTELLIVGTAYACMLISIVSLYLKMRRLGSKFWLFFSVLLSTLFSVQFAMTLVRASGVRISLVSLIESLPFLINVVALDKAAELTRQVITRCSVSDSHSPMHEDIAKACRNAAPPILRH... | 4 |
B9HTN9 | 3.2.1.52 | ACT_SITE 322; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MKSYLLLLFTICTFLLYSSAELDDNLTYVWPLPAKFSSGNNTLSVDPELSLVLGGKGGDSSIIKDGFGRYKKIIFKHSSKSYSVNKRLVFDIGVLKIVVLSDNEELQLGVDESYLLLVEKRNGQSIIGEAYIEANTVYGALRGLETFSQLCAFDYETKAVQIYRAPWYILDKPRFAYRGLLLDTSRHYLPIGVIKQIIESMSYAKLNVLHWHIIDEESFPLEVPSYPNLWKGSYTKWERYTFEDAYEIVDFAKMRGINVMAEIDVPGHAESWGTGYPDLWPSPSCREPLDVSKNFTFDVISGIMTDLRKIFPFGLFHLGG... | 170 |
B3RPJ9 | 2.3.1.48 | ACT_SITE 256; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038084-1" | MEVGKDHDLIASANEAIHLKLVSKGDEVLEKSESFHPEFTHQLFGDNEAIFGYKDLEIKLYYGSSSLLTYFGFTYSQKIDPSTSDGVKADDIIQILSDVLPQGFYTNQDEYMRVLEKEESNFKPFGEIINSYSLDDQTFEIRKANVDIPGFKAYHERLRTFLIWYIETASFIDDDDEKWTFYLLYHKRKDHNAFRYDIIGYMTSYNYYAYPDKIRSRISQIIILPPYQRNGHGAKLLESYYSLAEKDDNILDITAEDPSENFISLRDFVDCRRCAKLPAYSDQNLHDGFNENMANEARKKLKIHKKQARRVYEILRLKAT... | 61 |
Q09831 | 2.7.11.1 | ACT_SITE 320; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNELHDGESSEEGRINVEDHLEEAKKDDTGHWKHSGTAKPSKFRAFIRLHFKDSRKFAFSRKKEKELTSEDSDAANQSPSGAPESQTEEESDRKIDGTGSSAEGGDGSGTDSISVIKKSFFKSGRKKKDVPKSRNVSRSNGADTSVQREKLKDIFSPHGKEKELAHIKKTVATRARTYSSNSIKICDVEVGPSSFEKVFLLGKGDVGRVYLVREKKSGKFYAMKVLSKQEMIKRNKSKRAFAEQHILATSNHPFIVTLYHSFQSDEYLYLCMEYCMGGEFFRALQRRPGRCLSENEAKFYIAEVTAALEYLHLMGFIYRD... | 99 |
P04814 | 3.4.21.4 | ACT_SITE 71; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 116; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 210; /note="Charge relay system"; /evidence="ECO:0000250" | MLKIVILLSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTAAHCLQSVSASVLQVRAGSTYWSSGGVVAKVSSFKNHEGYNANTMVNDIAVIRLSSSLSFSSSIKAISLATYNPANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRNTMICAAASGKDACQGDSGGPLVSGGVLVGVVSWGYGCAYSNYPGVYADVAVLRSWVVSTANSI | 177 |
A0A078FX82 | 3.1.1.11 | ACT_SITE 243; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKDKAFVPAVLLLCFWVLLSSGSSRLLQSDDKGNELKNYISWEDMRVVEEVGRERRSSSVKVKDNNMVNQESNMATVNASRVIVVDKRGRGDSVTVQGAVDMVPDSNSQRVKILILPGVYREKVIVPRTKPYISFIGNESYAEYTVITWSDKSSDPYSNGTELGTYRTATVAIDSDFFCATAITFENTVVAEAGEEGKQAVALRVTGDKAMFYKVRVLGSQDTLNDATGSHYFFQCHIQGSVDFIFGNAKSLYQDCDIRSTARRFGAIAAHHRSEESDDTGFSFVNCDIGGTGKVYLGRAWGNYSTTVYSNCYIADIITP... | 125 |
C5XIT5 | 3.1.1.11 | ACT_SITE 400; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAAAFHTTTAALSAILALLLSLSLLVAVVRSDTAATPVTPSTACNETTDPNFCRTVLPSNGTSNLYTYGRFSVAKSLANANKFLGLVNRYLTRGGGGLSPGAVAALQDCQLLSGLNIDFLSSAGATLNTSGNSTLLDPQAEDVQTLLSAILTNQQTCADGLQVAAAAWSVRNGLAVPMVNSTKLYSVSLSLFTRAWVRSSAKANKSKSKPPRHGGGHGRGLFDATDDEMVRRMALDGVAAAVSVVGEVTVDPSGAGNYSTIGEAVAAAPTNLGGSTGYFVIRVPAGVYQENVVVPKNKKYVMMIGDGIGLSVVTGNRSV... | 125 |
A0A6I8NAL3 | 2.7.10.1 | ACT_SITE 1111; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1" | SGSGLGGGSSPVPSSLCPSQDIRHDVARLSALENCSVIEGHLQILLMSTATGEDFRARRFPRLVMVTGYLLLFRVYGLESLRDLFPNLAVVRGARLFFSYALVVVEMPHLRDLGLPALAAIARGAVRVERNQELCHVSTVDWGLLQGGRPEGNHIVANKPLEECAELCPGLRGGGERPCARTTVNGRSGFRCWTSAHCQRVCPCEGGTSCTAAGACCHPECLGGCGRTDDPRACVACRHFHFGGQCHRTCPPGTYQYEGWRCVTAAYCASLRAVSVAAAGGSSDFVIHGDVCLAHCPPGFTRNGSSVFCRKCEGLCPKRC... | 97 |
P67507 | 2.1.1.33 | ACT_SITE 118; /evidence="ECO:0000250" | MRVRNRKGATELLEANPQYVVLNPLEAKAKWRDLFGNDNPIHVEVGSGKGAFVSGMAKQNPDINYIGIDIQKSVLSYALDKVLEVGVPNIKLLWVDGSDLTDYFEDGEIDRLYLNFSDPWPKKRHEKRRLTYKTFLDTFKRILPENGEIHFKTDNRGLFEYSLVSFSQYGMKLNGVWLDLHASDFEGNVMTEYEQKFSNKGQVIYRVEAEF | 45 |
E3JV21 | 2.3.1.48 | ACT_SITE 351; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038084-1" | MAVTKARSSPRKPRVVITVSCSVGVAFPPSIDTRQVTTTTHIGLCAKSTKESDRSKPQAMAGEDPERWACDGTGALSLRLARGKVAADQLAPSEQHLISSFHPKFVYPLFGDEETIYGYEDLDIQLAFNSSTLKNYLAINYAAALPEPDPVEKIIYKFIPPDYTKSEATFNADLESSGTKKFIPPGKKISSYRTLPSKGKTKSEHFLTSKRWERCTDDQMEDEQDVIYELWAADWKSPGFREYHRRMQILVLFYIEGGSYIEEDDDRWEFVVLFERRKVKTADGDSSPYSYHFCGYVSLYSFYHYPSSIRLRLSQFIVLP... | 61 |
Q8T2I8 | 2.7.11.1 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSKKEPEEIKKNVTVGNYNLGVVIGKGGFGTVYQGLDIEDGDFVAIKQINLTKIPKDQLQGIMNEIDLLKNLNHANIVKYIKYVKTKDNLYIVLEYVENGSLSGIIKKFGKFPETLVCVYIRQVLEGLVYLHEQGVVHRDIKGANILTTKEGKIKLADFGVATKFDDTSAAAVVGTPYWMAPEIIELNGATTKSDIWSVGCTVIELLTGSPPYYDLGQMPALFRIVQDDCPPLPEGISPPLKDWLMQCFQKDPNLRISAQKLLKHKWIQASIKKKPVENGAGGVGNGTDSLGAPANIDDIAKNITDYNERINKKPSHQRK... | 99 |
A0A022QTV2 | 5.1.3.15 | ACT_SITE 157; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 261; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MSAETASSSTAGPPAPVQRPTRRFTGRNNRGGRSVILSQPGGYSTEAVYRPPQPIRGGIPICFPKFFDEEFLEKHGFARTEVWILTHDTAFPPPTPDHAYVDFLLDHKPDDFQDWPNHKFELRLRVILGPTGDLTMTTRVKNVNTNGEPFAFKFAYHSYFSVSNILATRIEGLQGLDYRDYLNHNQFTEEADVLTFEEELDRAYLNTPDEIRIRDLELRRVITIHKDDSLPEIVVWNPWEDDAGLISDFGYEEYKEMICVEAAAMDSEITLNPNEEWTATQRLSAKEY | 210 |
A0A1S4ALZ9 | 3.4.19.9 | ACT_SITE 257; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MSNYYFITISLFVAVVATAIESSSELSVPAGCPVPDPRLNYRPVIGIISHPGDGASGRIVNSTSVSYVAASYVKFVESAGARVIPLLFDDSPQVLNQKLDLVNGVIFPGGWARKGKYFETVKAIFKKVLEKNDAGEHFPLLAINLGFELLMMIVSKDNNILEKFSVSNQASKLHFVETVNIEDTVFGRFPPTLIKKLSKECLVLQRNKYGLSPEKFQANDDLSSFFIMLTTSTDTRNKVFVSTLQAENYPITALQWHPEKSAFEWGSAAIPHSEDAVQVTQLVANYFVSEARKSSNKPDAQKVLDNLIYNYSPTYSGKAG... | 176 |
Q54RB7 | 2.7.11.1 | ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MATQQQQQQQQQQQQQIKARKDIQIQQAQSASDILGPPEISETEITTESILGDGSFGTVYKGRCRLKDVAVKVMLKQVDQKTLTDFRKEVAIMSKIFHPNIVLFLGACTSTPGKLMICTELMKGNLESLLLDPMVKLPLITRMRMAKDAALGVLWLHSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEVLQGRLFNEKADVYSFGLVLWQIFTRQELFPEFDNFFKFVAAICEKQLRPSIPDDCPKSLKELIQKCWDPNPEVRPSFEGIVSELEEIIIDCCIPDEYGAILWKN... | 99 |
A0A2R6WP24 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASTRNLVLFFTVTLFLRISVDAEFMKPHDLLKDNFYKDSCPNAEAVIRRAVFTAAEKNLKLAAGLIRLQFHDCFVEGCDGSVLLDGNDTEKTAPVNEHLKGFRVVDAAKAAVEEVCPGVVSCADVLAYAARDSTVMLNGTRFEVQGGRKDGLFSCAEAAERDLPPPTFNASQLIDSFAKRGLSAEQMVVLSGSHTVGVGHCDKFIERLYNFSEAHATDPSLNSTYAKQLKRDCPKRNFNSTLEIFMDTMTPGEIDSNYYVGLTQRKGLFTSDQTLFEDRRTRKFVRRLMNEGRFDRRFGEAMRAMGAVGVQFEGQIRKN... | 14 |
A0A1L8FAK5 | 2.7.11.1 | ACT_SITE 856; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MAGGRGNAVLPIDLDLPRPPPPTSEAAETYSIRQENELEVLESIYSGDFTDLRRNNVWKVQQPPEITIALRPQGNEVYVKVDLWIKCPQNYPDVPPEIKLMNIQGLSNENVNSLTSSLADLSKQLCGEVMIYQLADHVQCFLTEYNLPPPKSFHEEMLKNLQKQQEKLALEEEKRVQQIRMQEEQMRREILDEIQKREEEKKEAKRKKEIAKQERIESANQMCQENVNKINNTGKTITASSDGSVTDHGGTNRNRPHSAGRSKRDRQYSVCITEDATLFEVLTFDLGCSGQVVVHRGKCLGKDELLGKSVYNGLEIASGN... | 99 |
Q8A1R1 | 3.2.1.52 | ACT_SITE 304; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MKLLLTTLAIVYLSLFMSLQAQEQVRVIPYPAEVTMQAETCKLKSGQKIHYLDASLYKEAAFLEKKLADLNYKMKVIPGKKAVKGINLSLNNRLQNKEGYQLIIAPKQVLIKGGSPAGVFYGIQTLLQQLTNGDLRCGTIEDAPRYEWRGYMLDEARHFSGEKRVKQILDLMAYYKMNRFHWHLTDAQGWRIEIKQYPKLATIGGEGCHSDPDTPAQYYTQEQIRDIIAYAKERHIEIIPEIDMPGHATAANKAYPEYSGGGTEEHPEFTFNVGKEETYTYLTNILKEIAALFPSPYLHIGGDEVAYGIKAWETDPHVQA... | 170 |
P40160 | 2.7.11.1 | ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000250" | MKLDTSHMRYLTTDDFRVLQAVEQGSRSHEVVPTPLIHQISGMRSQSGTNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMSMLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHKNIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDFPQCISIQHQDADYYFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKRTDN... | 99 |
A0A2I3TU63 | 2.7.11.1 | ACT_SITE 243; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | DQSEENCISGPVEAKTPAGGPKHVLVTQQFPCQNPLPANSGQAQWVLCPSNSSQRVPLQAQKLVSSHKPVQNQKQKQLQATSVPHPASRPLNNTQKSKQSPLSAPENNPEEELASKQKNEESKKRQWALEDLEIGRPLEKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLQHPNIIRLYGYFHDATRVYLILEYTPLETVNTELQKLSKFDEQRTATYITELASALSYCHSKPVIHRDIKPENLLLGSAGELEIANFGWSEHAPSSRRTTLCGTLDYLPPEMIEGQIHDEKVDLWSLGVLCCEFLVRKPPFEANT... | 99 |
B3RSA1 | 5.1.3.15 | ACT_SITE 148; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 252; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MAAADDVVELNLDQENICKVNLHGATLTSWLCDGTEMLFVSQQAVFNNVKAIRGGIPIVYPHFGPWELGPQHGFARISRWTLEKPPAKDGDTVSATFLLQDNENTRQMWQDNRFNLFYTVIIGKRQLKLKLDVRNEGNDSFEFTTLLHTYFKTLDVNKVTISGLKSLKYIDKVRQSKKFVEENDLVTVKEFVDRLYIGSVDRNEVTNLNGNQNVVMTRVNLPDVVVWNPWQEKAKVMSDFGDEEYKEMICVEAGYVAKPRSLSAGARFEASVVLDVI | 210 |
A0A2R6W8U3 | 1.11.1.6 | ACT_SITE 65; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 138; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MDPYKFTPSSKYNSNHWTTNSGAPVWNNNSSLTVGPRGPVLLEDYHLVEKLAQFDRERIPERVVHARGFSAKGYFEVTHDISHLTTADFLRAPGVQTPLITRFSTVIHEIGSPETLRDPRGFAVKFYTREGNFDMVGNNIPVFFIRDGMKFPDMIHSLKPNPKTNVQEMWRAMDFFSHIPESLHMFSFLFDDWGVPYNFRHMEGFGVHTFKLINKAGKETYVKFHWKPSCGVKFLLEEEAVIVGGTNHSHMTQDLFDTIAAGNYPEWGLFIQTMEPCMEDAYDFDPLDDTQTWPEDKFPLQPVGKMVLNKNIDNNFAENE... | 13 |
A0A1L8G7Q7 | 5.1.3.3 | ACT_SITE 176; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 307; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MTSVTRDVFGQLLGGEGTVERFCLHSKEVRAEVISFGCIITRLETQDRNGTFSDLVLGFDVIEGYTNKHPYFGAVIGRVANRIANGKFTVKGKDYRLAINNGPNSIHGGLKGFDKVLWAPKIIENGVQFFYKSADGEDGYPGELNVWVTYTLIGRTLTVNYRAQSNNTTPINLTNHSYFNLAGQGSSNVYDHVVSIDADHYLPVDDTMIPTGEVAPVLGTCFDLRKPVELGSHLKSFHLDGFDHNFCLGVTQEQKQCARISHPLSGRVLTVSTTQPGVQFYTANFLDGSLKGKAGKVYPKHSAFCLETQGWPDAVNKPHF... | 211 |
Q4WLY1 | 3.2.1.21 | ACT_SITE 233; /evidence="ECO:0000250" | MGSIDTVGMGQRAIDQIISELSLNEKVALLSGVDAWHTFAIPRLGIPSIRTTDGPNGARGTRYFNGVPSACLPCGTALGATFDRDLIFSLGQLLAAECRAKGAHVLLGPTINIQRGPLGGRGFESFSEDPVLSGLAAASYCSGVQDGGVVPTLKHLVCNDQEHERVAVSALVTPRALREIYLLPFQLAIQGARPGAVMTSYNKVNGLHASENPGLIRDILRGEWGYEGAVISDWFGTYSVADAVNAGLDLEMPGPTRFRGPALMHALTSNKVSEKTLNERVRKVLELVQLASRAGVPEYAPERKLNRPEDRALLRRAAGE... | 161 |
C4LUV8 | 2.1.1.33 | ACT_SITE 143; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MSSEHQTTEHSHNSIIKKKKGIKPFHRVHAHRNPLADSPSTNPITPQSLDWKLYFPNGKPAEMLDIGCGWGGLVREVGMIQEKNVLGMEIRDPAVQYGLEKIQAAREKNELKNVWIIQCNCMKYVDNYFVKGQLLKIFITFPDPHFKNSVKRRRIINPHFAAMYVYLLKPGEGMLYTASDVKELFDWNTQSLDQQPLLERMPDDYTDDYLNIVMFKTEEAKKVDREQRQKWGACYRRRIEEPF | 45 |
M4CYV9 | 3.1.1.11 | ACT_SITE 475; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQTQHFSSSLLFLTLLCLSWASLISSTQPPTQTPLQPPTQPPTQPPSKPPSQPPPRPTSQPPSQPPSQPTSQPPSQPPSQPPSKPPTQPPSKPPTQSSQQANVACKSTPYPKLCRTILSAFKSSPSDPYRYGKFTLKQCLKQARRLSKVINRFAQRVEKDPKASTPEEVSAVADCGDLAALSVEYLEAVTDELKSAELMTEALVDRVSSLLGGVVTNQQTCLDGLEDANSAFATVLGSPLGNVTQLYSVSLGLVSNALSRNLKRYKGSKGKIFGGGNKAIREPLETLIKVLRKTCDKSKECRHDRSLGELGETSGGSILV... | 125 |
A0A3B3I0J6 | 3.4.19.12 | ACT_SITE 328; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 822; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MAADLGELLVPYMPTIRVPRTGDRVFKSECAFSFDSPESEGGLYVCMNTFLGFGREHVERHYRKTGQSVYMHLKRHVKEKTTGAAGGAIPRRRNGKVFLDLELNRDFNGEDFEYEDEAKLVIFPDHFEIPLPNIEELPALVTIACDAVLNAPSAYKKQEPESWEEEIQVSRHARSLRQLNNGVRIPPSGWKCQKCEMRENLWLNLKDGAVLCGKWFFDGSGGNGHALEHYKETNYPLAVKLDTITPDGADVYSFEEEEAVLDPHISEHLSHFGIDMLQMQKRTENGHHTENNSRLRVSEWEVIQESGMKLKMVYGSGYTG... | 175 |
C5YLR6 | 3.1.1.11 | ACT_SITE 410; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASTSTSTFPRATAPQLLLLVLSLLLAAASASSLLPPLNNAHPQRPSPVAKAREEEGGGGSAGLISTLRETLDAIRDVASIISSFPISVGGGILGGGAGDLRLSSAVADCLDLLDLSSDELSWSMSTTTSSSDGYSPASAGAGAGAGGRVVGTGDDRSDLRSWLSGALGNQDTCKEGLDETGSPLASLVATGLDAVTSLLADGLGQVAAEEAVAAEEAVAASSASSRRGALGAAAPPPRWVRARERRLLQMPVGPGGLAVDAVVAQDGSGNFTTVSAAVDAAPSQSAARHVIYVKKGVYRETVEVKKKKWNLMLVGDGMG... | 125 |
E7F9M6 | 2.7.1.11 | ACT_SITE 166; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MSSAGLEKLRMTGAGRAIAALTSGGDAQGMNAAIRAVTRMGIYVGAKVYLVYEGYQGLVDGGDNIKLANWQSVTNIIQLGGTVIGSARCKAFTMREGRLAAAFNLVKRGISNLCVCGGDGSLTGANIFRAEWSGLLEELVQKGRITAETAQKHGHLNIVGLVGSIDNDFCGTDMTIGADSALNRITEIIDAITTTATSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWEELMCARLEESRSKGCRLNIIIIAEGAISRSGEAITSNYIKDLVVSRLGYDTRVTVLGHVQRGGTPSAFDRVLSSKLGVEA... | 84 |
A8KB50 | 3.4.19.9 | ACT_SITE 130; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 240; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 240; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MYRQVLVLAVFAACLCGFPASCARNLNYRPIIGILAQENLEEDPHAQGTSYIAASYVKHLESAGARVVPIRINRTEEEYETLFNAINGLLLPGGNVDIETSQFTRAARIFYELALKANDASDYFPIWGTCQGFQQLTVLTSNKNLLTLTDTKAVALPLTFSPGAQNSRLFKKFPKDVLQSLAEENITSNFHSWSLSTQNYSANPKLKRFYRVLTTNTDGRKEFISTMEAYRYPFYAVQWHPEKSPFEWIEKSGMVHTLSAIKATFYTAHFFVSEAMKNRHQFPSQIEEEKALIYNYQPVYNGLNSIFLQNYYFD | 176 |
O49139 | 2.1.1.37 | ACT_SITE 417; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016" | MAARNKQKKRAEPESDLCFAGKPMSVVESTIRWPHRYQSKKTKLQAPTKKPANKGGKKEDEEIIKQAKCHFDKALVDGVLINLNDDVYVTGLPGKLKFIAKVIELFEADDGVPYCRFRWYYRPEDTLIERFSHLVQPKRVFLSNDENDNPLTCIWSKVNIAKVPLPKITSRIEQRVIPPCDYYYDMKYEVPYLNFTSADDGSDASSSLSSDSALNCFENLHKDEKFLLDLYSGCGAMSTGFCMGASISGVKLITKWSVDINKFACDSLKLNHPETEVRNEAAEDFLALLKEWKRLCEKFSLVSSTEPVESISELEDEEVE... | 47 |
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