Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0QWW2 | 1.2.1.12 | ACT_SITE 159; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362" | MTIRVGVNGFGRIGRNFYRALATQKAEGKNTDIEIVAVNDLTDNATLAHLLKFDSILGRLPQDVSLEGDDTIVIGDTKIKALEVKEGPAALPWGDLGVDVVVESTGIFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCLGPLAKVLNDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVLPELKGKLDGYALRVPIPTGSVTDLTAELAKSASVEDINAAMKAAAEGPLKGILKYYDAPIVSSDIVTDPHSSLYDAGLTKVIDNQAKVVSWYD... | 22 |
F4PA56 | 2.7.11.23 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MITPKYSAYEKEKKVGEGTYAVVYQGWAIPNTALDKRKVAIKKIKIGQFKDGLDMSAIREVKLLKELHHVNIVELIDVFAHKTNLNLVLEFLDADLEMIIKNKNVVFSAGDIKSWMLMMLRGLFHCHRNFILHRDLKPNNLLLSSTGQLKIADFGLAREFGDPTRAMTSQAVTRWYRAPDLLLGAKQYGTAVDMWSVGCIFAELMLRTPYFAAETDIGQLQTIFRALGTPTEEDWPGLKSLPDYHEFAMHPKTALSVLFTAASNDTLDLLQRMIIYDPLKRITSEQALDHVYFRNLPRPTDPSRLPKDTNGQTQQNTAAD... | 103 |
A0A3B6CH96 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASRTAAATVVVLALVCAVQSSLSVAAATGGLSPDFHAATCPALEHIVADHVWKAFKNDSGVAPALIRILFHDCFPQGCDASVLIEGPGTEQDEIPNRTLRRVALDLIERIRATVHTECKATVSCADITILATRASLIMAGGPRFDVTLGRRDSFFPASKDQVGLLPAPFHPVDTLIKSFGDRGLNVEDLVSLSGAHTFGVAHCPAFHDRFKDGFDTNPAIDRRFATMLRNKCAKDTPEGTLKQNLDVRTPDVFDNKYYFDLIARQGLFKSDQGLMNHTATQRMATRFSLNQDAFFQQFSKSMAKMVNMDLLTGDKGEIR... | 14 |
M4ETV9 | 1.11.1.24 | ACT_SITE 61; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPGITLGDTVPNLEVETTHKNFKLHDYFADSWTVLFSHPASPIYLLSLLTNGLQGDFTPVCTTELGAMGKYAHEFEQRGVKLLGLSCDDIQSHKDWIPDIEAFTPGSKVTYPIIADPNKEIIPQLNMVDPIENGPSRALHIVGPDCKIKLSFLYPSTTGRNMDEVLRALDSLLMAAKHKNKIATPVNWKPDEPVVISPAVSDEEAKKLFPQGFKTAELPSKKGYLRVADVS | 12 |
A0A0R0HGS5 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGSQSCFKALIICLIALIGSTQAQLQLGFYAKSCPKAEKIILKYVVEHIRNAPSLAAALIRMHFHDCFVNGCDGSVLVDSTPGNQAEKDSIPNLTLRGFGFIDAIKRLVEAECPGVVSCADILALTARDSIHATGGPYWNVPTGRRDGLISRAADPLRSLPAPFHNLTTQLTLFGNVGLDANDLVLLVGAHTIGVAHCSSIATRLYNFTGKGDIDPTLDSEYAKNIKTFKCKNINDNTIIEMDPGSRDTFDLGFYKQVVKRRGLFQSDAEFLTSPITRSIIDRQLQSTQGFFEEFAKSIEKMGRINVKLGTEGEIRKHCA... | 14 |
C5XHZ4 | 3.2.1.14 | ACT_SITE 113; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MAYPCAVHGALWIAVVAFLVASGSVVVIRVAEARYGPGHWNPAAPAPVATLVSEQLYNSLFLHKDDAACPAKGFYTYASFIQAARTFPKFAATGDLSTRKREVAAFFAQISHETTGGWATAPDGQYAWGLCYKEEISPASSYCDATDKQWPCYPGKSYHGRGPIQLSWNFNYGPAGQALGFDGLRNPEVVANCSETAFRTALWFWMTPRRPKPSCHEVMVGEYRPTAADAAANRTAGFGLVTNIVNGGLECNRTDDARVNNRIGFYQRYCQIFNVDAGANLDCAHQQPY | 158 |
C5CPN2 | 2.2.1.2 | ACT_SITE 126; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MNQLDALRQWTTVVADTGDFKQLAISRPQDATTNPSLILKAVQKPEYRPLLDEAVSKHAGKPLDEVIDRLLVRFGTEILSIIPGRVSTEVDARLSFDTAATVARGERIVALYKAEGIDTEKRLLIKVASTWEGIEAARTLEQKGIRTNLTLLFSFAQAVACGAAGVQLISPFVGRIYDWYKKSAGAQWNEAASAGANDPGVKSVRQIFEYYKQHGIKTEVMGASFRNVGQIRALAGCDLLTISPELLAELAASNEPLAHALDAKAATGGDVAKVSYDEAGFRFALNEDAMATEKLAEGIRAFAADAVKLEKLMQESGK | 52 |
Q7UHZ5 | 3.5.1.88 | ACT_SITE 135; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MPLSIIHFPHPTLRHVSRPIVRVDAKLKSMADEMLDLMYEFDGVGLAANQVDLPIRMFVANPTGKRDEGESWVILNPEIDRPKGNDTAQEGCLSVPGLYGQVKRPKTVRLRGFDLQGNEINQVLDGFMARVVQHEVDHLDGIMFFDRIGEEGLRDLEGHLEEFKTDYESKQGTGSIADEATLAQQRAEWEAMYTGGTTSNG | 183 |
A0A1U8FXF2 | 3.2.1.14 | ACT_SITE 91; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MKFLSSPLALTCVFFLFLTGSLAQDVGSIVTNDLFNNMLKNRDDDRCPAKGFYTYDAFIAAANSFQGFGTTGDDSARKKEIAAFFGQTSHETTGGSLSADGPFAGGYCFVREGNQMGSGFYGRGPIQLTGQSNYDLAGQAIGQDLVNNPDLVATDATVSFKTAIWFWMTPQGNKPSCHDVITGQWTPSAADTSANRQPGYGVITNIINGGIECGKGQNPQVEDRIGFYQRYCTILNVAPGDNLDCYNQKNFAEA | 158 |
G1KPQ5 | 2.7.10.1 | ACT_SITE 645; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MEMNQTMQIRGLLLLLPALLWALLLRRDVAAGTGTKVTGMPIKLKVSQGQPVKLNCSLEGMEDPEMLWIKDGAVVQSVDQVYIPVDEEHWIGFLSLKSVDRTDSGKYWCQIETNGKKEESQQVWLIVEGVPYFTVEPEDLSVVPNTPFHMVCAAAGPPEPVTIVWWMGDSRIGPSDVSPSTLNVSGINQSTVFSCEAHNIRGLSSSRTATVHIKVLPFPPLNVTVTQITSNNANVIWLPGFDGLSPLLSCTVQVAESQAEEEVVTEVVPVPSFNRALLGLKHSTNYSVRVQCTNEMGSSPFTDWVNFQTLGLAPNNTPQN... | 97 |
A0A1L8I1Z7 | 3.2.1.52 | ACT_SITE 351; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MALRRVAVLGILSLSFYLSPSLCLRSHSHGELLDAETQLTVAEDSPYGSLWPLPQTVTFSADTFRIPPSAFSIVHGSGSTVGASCVMLQDAFRRYYDYMFGYSKWKHLSEKPSDAGQLLQLQVIILSQDHECHQYPTVKSDESYELSVGENVAVLKAKQVWGALRGLETFSQLIYEDSFGAFLINKTHIEDSPRFAHRGVLLDTSRHYLPLKTIFLNLDAMAFNKFNVFHWHIVDDPSFPYQSVTFPDLSDKGSYHPYTHVYTPIDVRMVIEFARMRGIRVVPEFDSPGHTDSWGKGQQNLLTPCFNKEKLTGTFGPVNP... | 170 |
Q9P376 | 3.1.3.16 | ACT_SITE 170; /evidence="ECO:0000269|PubMed:11934898"; ACT_SITE 172; /evidence="ECO:0000269|PubMed:11934898" | MSKRLTPIHLPNSLNYPIEIASCLVPQGSYVKKGTPLLLYRFFTKVKEDQEDGSEVYVDREFVEQFECPVEGELVEWAVKKEESIENFSKIVAKLHEPCTHEVNYGGLCAICGKNITSQDYMGYSDMARANISMTHNTGDLTVSLEEASRLESENVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVLRDVRSFNLQEGPSGYTSCYYIKFRPGLAQFLQKISELYELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSGSLAQKSLRRLFPCDTSMVVVIDDRGDVWDWNPNLIKVVPYEFFVG... | 144 |
Q94DM2 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASRTSATAGMLLLAAAAALVCSSAAARMPPLAKGLSLGYYDASCPQAEAVVFEFLQDAIAKDVGLAAALIRLHFHDCFVQGCDASILLDSTPTEKSEKLAPPNKTLRKSAFDAIDDLRDLLDRECGDTVVSCSDIVTLAARDSVLLAGGPWYDVPLGRHDGSSFASEDAVLSALPSPDSNVTTLLEALGKLKLDAHDLVALSGAHTVGIAHCTSFDKRLFPQVDPTMDKWFAGHLKVTCPVLNTNDTTVNDIRTPNTFDNKYYVDLQNRQGLFTSDQGLFFNATTKPIVTKFAVDQSAFFDQYVYSVVKMGMIEVLTGS... | 14 |
Q96WV1 | 2.1.1.33 | ACT_SITE 173; /evidence="ECO:0000255|HAMAP-Rule:MF_03055" | MSATAKKSAAQLQREEEEARKKLKRLSKQGGVEGRLPMKRLFRQRAHANVLSDHELEYPRSPSEMDWSPYYPDFDVESNKKVEIVDIGCGYGGLTVALGPQFPDTLVLGMEIRMQVSDYLKEKIQALRYRADHEEPVPGGYKNISVLRMNCQKFLPNFFEKGQLSKMFFCFPDPHFKARKHKNRIITSTLASEYAYFIRPHGTLYTITDVEELHVWMAQHLDAHPLFRRFTKEEEENDICVTLMTNETEEGKKVARNGGKKFVACYERIPNPK | 45 |
P40857 | 4.2.1.134 | ACT_SITE 149; /evidence="ECO:0000305|PubMed:18272525"; ACT_SITE 156; /evidence="ECO:0000305|PubMed:18272525" | MSKKLASPLSFLPLYNLLSAVGWSYLLYLVISLYPKVGQPAFFYQTKNVATLVQCGAIIEIINSFLGVVRSPLLTTVAQVSSRLLVVLGIFQLLPNTSGVQSVVYISLLLAWSITEIVRYLYYFFMLVFKNGAPKILILLRYNLFWILYPTGVASELRIIYCALNAAESQYSLLYKRILIAAMLAYIPGFPMLFLHMVAQRKKVMKSLRSSFGKKLI | 201 |
A7EIH3 | 3.5.1.2 | ACT_SITE 81; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 188; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 190; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 232; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"... | MSKVYLLDYVAGNVRSLVNAIEKVGYTIEWIKSPEDVPKADKLILPGVGHFGHCMTQFSSAGYLPAIRKHIESGKPFMGICVGLQALFEGSAENPAVPGLGIIKATLDRFDDSSKSVPHIGWNSANTSGEEVYGLRPSSKYYYVHSYKVPYKQGELESQGWTVATARYGDEEFVGAIAKGNILATQFHPEKSGVAGLRVIKAFLDGNNTSSAVEGLVAAKEGLTRRVIACLDVRTNDQGDLVVTKGDQYDVREKTDGGNVRNLGKPVEMAKKYYEQGADEVTFLNITSFRDCPLVDVPMLEILRQTSKTVFVPLTIGGGI... | 181 |
P32821 | 3.4.21.4 | ACT_SITE 64; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 108; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 200; /note="Charge relay system"; /evidence="ECO:0000250" | MKICIFFTLLGTVAAFPTEDNDDRIVGGYTCQEHSVPYQVSLNAGSHICGGSLITDQWVLSAAHCYHPQLQVRLGEHNIYEIEGAEQFIDAAKMILHPDYDKWTVDNDIMLIKLKSPATLNSKVSTIPLPQYCPTAGTECLVSGWGVLKFGFESPSVLQCLDAPVLSDSVCHKAYPRQITNNMFCLGFLEGGKDSCQYDSGGPVVCNGEVQGIVSWGDGCALEGKPGVYTKVCNYLNWIHQTIAEN | 177 |
A0A022RP40 | 3.4.19.12 | ACT_SITE 27; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 127; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 142; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MNSSSEGGGGASNGGILYHEVQESKLCAVHCVNTVLQGPFFSEFDLAALASDLDRTERQMMLGSVTGDYLPELSHNVSLDGDFSIQVLQKALEVWDLQVIPMNSPVAEPAQIDPEKENAFICHLQDHWFCIRKLNGEWYNFDSLLAAPEHLSRFYLSAYLDSLKSFGWSIFLVRGNFPKECPISSSEASNGYGQWLSPEDAERITKSCNSASSRRALVPYADVEAVPDDEDEDLKAAIAASLLDSAPPPPPPPTIGGEQPGTSPEENKNSGA | 175 |
B9S9Q8 | 3.1.1.11 | ACT_SITE 245; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSVLGFNAYLSQLLIIIEKRGKSMERSVLGVSVVVYICFLGSFQVVFSQSGVVNMKDFISWDDMKVDEDKAKLNSRYDYNRSRIIVVDRNGEGDSLTVQGAIDMVPESNPHRVKIYILPGIYREKVLVPSTKPYISFIGKESQCADTVITWNNKASDMDSNGVELGTYRSASVTIESDYFCATGVTFENTVVAEPGGYGMQAVALRVSGDKAFFHKVRILGTQDTLLDETGSHFFYQCHIQGSVDFIFGKGRSLFQDCVLQSTAKRSGAIAAHHRDTPFDDSGFSFVGCVINGTGKILLGRAWGNYSRAIYSYCFIDDVI... | 125 |
Q7NE61 | 1.8.4.12 | ACT_SITE 120; /note="Nucleophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_01400" | MPTKVFKSEAEWKKILTPEQFLITRKKGTERAFTGKYHDTKQAGIYQCVCCETPLFSSAQKYDSGTGWPSFWGPVNPKNIATKADFSLFMRRTEVLCAVCDAHQGHLFNDGPPPTGLRYCINSAALKFVKLPLVSRLGRGFIEYLTSQA | 40 |
O66847 | 3.5.1.88 | ACT_SITE 136; /evidence="ECO:0000250" | MVRDIVIYPNEILKKPTEKVDVIDKEVKNLIRDMFDTMYEAEGVGLAANQIGVPLSVMVIDTSPKEDAPPLKLVLINPEIKEGEGKIKYKEGCLSFPGLSVEVERFQKVKVNALNEHGEPVELTLEGFPAIVFQHELDHLKGITFVDRLKGWRRRMALEKYQKLLKSRK | 183 |
F4NRH1 | 3.5.1.2 | ACT_SITE 94; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 206; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 208; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 263; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"... | MVTSQGSTHAALIDADIYLLDYGAGNVRSLVNAVNHIGYSIKRIESVADFDKAKKIIFPGVGAFGSCMVKLQELGYIESLQKYIRANNPFFGICVGMQSLFLASDESPDIQGLGIISATVSKFDATTKTVPHMGWNTTTLQVDTRIHHGGADNRYYFVHSFAVKGSQAEIDASPDLRDWAYSLTTYGNETFVSIIQKGNIFGTQFHPEKSGHLGLAVIKAFLDSKPADASLPKPIPLDGLPHSKRAYCMPQSQLSRRIIACLDVRANDNGDLVVTKGDQYDVRESAKDGGHVRNLGKPVELAQRYYQEGADEITFLNITS... | 181 |
P28274 | 6.3.4.2 | ACT_SITE 404; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 535; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 537; /note="For GATase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00605" | MKYVVVSGGVISGIGKGVLASSTGMLMKTLGLKVTSIKIDPYMNIDAGTMSPLEHGECFVLDDGGETDLDLGNYERYLGVTLTKDHNITTGKIYSHVIAKERKGDYLGKTVQIVPHLTNAIQDWIERVAKIPVDDTGMEPDVCIIELGGTVGDIESAPFVEALRQFQFKVGKENFALIHVSLVPVIHGEQKTKPTQAAIKGLRSLGLVPDMIACRCSETLDKPTIDKIAMFCHVGPEQVVNVHDVNSTYHVPLLLLEQKMIDYLHARLKLDEISLTEEEKQRGLELLSKWKATTGNFDESMETVKIALVGKYTNLKDSYL... | 252 |
A0A3B3ILV5 | 2.3.1.48 | ACT_SITE 529; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MPRRKRTAGSSSDGTEDSDFSADLEHADASDNGRRRSSARLTRSSLRLSQSSQENCRPARRLSSAAAARDDGPDVSADSAAPASVFSSGRRITRSQQGASSTTAKKYPLRQSRSSGSDTEANDGKHGADRDETPPRTPTGNASSSESDLEVSSSNNETVTSNDIIVSQEEDERLAKELSLKEAAAHDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGRHERHFSISGCPLYHNLSADECKGKASTRDKLAEERTLSHRHDENRHSTRNQAPSDRQLRYKEKVTDLRRKRDSGLNKEQKDKYMEHRQSHGTSREPLLE... | 61 |
Q2U325 | 3.2.1.21 | ACT_SITE 304; /evidence="ECO:0000250" | MASIAHLVVSGLLAATAVNGQNYGGSGRSDDAFSYVQPRNTTILGQYGHSPAVLPSPNATGAGGWEEALAKAQQFVAQLTLEEKADMVTGQPGPCVGNIVAIPRLGFKGLCLQDGPLAIRVADYASVFSAGVTAASTWDKDILYERGVAMGEEFKGKGAHVALGPVAGPLGRSGYGGRNWEGFAADPYLTGVAMERTIQGYQDAGVQACAKHFIGNEQETQRNPNYNPNGTLTDVIQEAISSNIDDRTIHELYLWPFANAARAKVASVMCSYQRLNGSYACQNSKVLNGLLKEELGFQGYVQSDWGGTHSGVSSIEGGLD... | 161 |
F7B2I8 | 2.7.10.1 | ACT_SITE 837; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MGLYGAAGAAVLVLLVGHFSQGLALEEKKVCQGTSNKLTQLGTFEDHFVSLQRMFNNCEVVLGNLEITYVQKNYDLSFLKTIQEVAGYVLIALNAVEKIPLENLQVIRGNVLYENFYALSVLSNYDVNKTGVKELPMRNLLEILIGGVRFNNNPSLCNVETIQWKDIVNPIYINNITIDNNSHPKSCEKCDSSCPNGSCWGPGPQYCQTLTKTICAQQCSGRCRGSSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDNCPSLLQYNPTTYQMDVNPDGKYSFGATCVRKCPHNYVVTDHGSCVRSCNADTYEVEE... | 97 |
Q6C8C6 | 1.8.1.4 | ACT_SITE 478; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MLRTTRILPSKFGVAARTRAVTQFQRCYSSANEELDVLVIGGGPGGYVAAIKAAQAGLKTGCIEKRGSLGGTCLNVGCIPSKSLLNNSQMYHAIKTDSANRGIEVSDVKMNIAKLQEAKETSVKGLTGGIEMLFKKNKVNYYKGAGSFVSDSEVKVDPIDGGEAVTLKAKNIIIATGSEPTPFPGITIDEKKIVSSTGALALEAVPKKMVIIGGGIIGLEMGSVWSRLGSEVTVVEFQNAIGAGMDDEIAKAAQKMLTKQGIKFKLGTKVLSGAIEGDGVKVEVENVKKGDKETLDADVLLVAIGRRPYSEGLNLEAAGV... | 36 |
A0A0Q3G9D9 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSKRNENVSLSVLLASAVVAILLAAQVNVKPAMAGDYTIGMQTKVRDIVQRNRAVAPGLIRLAFHDCWVKGCDGSVLLERADKQAEMDAPQNGGIRGLDLIQAIKDTLSLDDSTVTCADAVVYAAREACNVLSGGNIVYAVDGPGSHKDTNASSMADAGALPGPTASFANLAANFNGKGFTPRDVVVLSGAHAVGLAHRPNFEARLTANANEISQKYRNDVNVISNASPNKTAHNNVRDLDKAETEPGVLDNNYYAANLGKKVLFSSDFALTTDGAALNNMTNFKNDATMWFRLFEDAMARLSRLPAQGADVLQVPRIKC... | 14 |
Q8Y915 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 596; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGYIGTNNAKGILLEGLEKLEYRGYDSAGIALQNKELVTVVKEKGRIADLASLVPSDAFGTTGIGHTRWATHGKPNHENAHPHQSKSGRFTIVHNGVIENYTLLKEEYLKNHSFVSDTDTEVIVQLIELFAAELSTKEAFKKALSLLHGSYAICLIDQTNTETLYAAKNKSPLLIGKGENFNVIASDAMAVLKETDEFVEIMDKEIVIVTKDGFTLETLEGEEITRASYKAELDASDIEKGTYPHYMLKEIDEQPAVTRKIIQAYQDEAGEINVDKTIIDEILSSDRIHIVACGTSYHAGLVGKNLIEKMAKIPVE... | 81 |
B7P894 | 3.4.21.92 | ACT_SITE 102; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 127; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | EKILMSYVPIVIEQTSRGERAYDIYSRLLKERIIFVCSTVEDHMTNLIVAQLLFLEAENPKKDIYMYINSPGGVITAGLAIYDTMQYIKPKVATLCIGQACSMGSLLLCGGEKGMRYSLPHSRIMIHQPSGGYKGQATDIEIHAQETLKIKRLLNELYSKHTRQELKHIEKSMERDNFMSPEEAKKFGIIDNIISSRDAMTMSAK | 179 |
A0A1U8K4S4 | 1.11.1.7 | ACT_SITE 93; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQRQGRKRNTKNLSMAKVTNFFVALLLISSLLLAPYLSISEAADNSVPIVSGLSWTFYKTSCTKLESIIRTQLKKVFDNDIGQAAGLLRLHFHDCFVQGCDGSVLLDGSASGPGEQQAPPNLSLRAKAFEIINDLRNRVEKACGRVVSCSDIVALAARDSVYLSGGPDYGIPLGRRDGLTFATVNATLQNLPPPFANATTILSMLATKNFDPTDVVALSGGHTVGISHCTSFTTRLYPTQDPTMDKTFANNLKVICPTVNSTNTTVMDIRSPNKFDNKYYVDLMNRQGLFTSDQDLYTDSRTRGIVTSFAINETLXXXXX... | 14 |
A0A2K1J1R3 | 3.5.1.2 | ACT_SITE 78; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 192; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 194; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MAVGVLALQGSFKEHIVCLRKLGVDAVEVRKLEQLVGLSGLIIPGGESTTMAKLAEKNNLFPALREFSTAGKPIWGTCAGLIFLADRASGVKEGGQKLLGGLDCTVHRNFFGSQLNSFEMELSVPTLASREGGAETCRAVFIRAPAIVDVGSSVEVLAEYPLAPGQAPQQEVGKDKVIVAVKQNNMLATAFHPELTSDLRWHKLFLNMINDGGEGAQVPGAERIVAKKTNVPPALDQIRDMPVFREASFLSLELQ | 181 |
F4JPX3 | 2.7.11.1 | ACT_SITE 221; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MNCLFLFMSKKPKSRGNMEKEKKNIRGREFLQKSAPELTTRKTTLSFNLPTPRSLPSPTSIKDLYTDREQNQNQNLRVFSFKELSDATCEFSRKLKIGEGGFGSVYKATINNPTVGDSHSSPLTVAVKKLNRQSLQGHKQWLAEVHFLGVVNHPNVVRLLGYCSEDRERLLVYELMSNRSLEDHLFTLRTLTLSWKQRLEIMLGAAQGLAYLHEIQVIYRDFKSSNVLLNEEFHPKLSDFGLAREGPEGDNTHVTTARVGTDGYAAPEYVITGHLKTHCDVYSFGVVLYEIITGRRTLERMKPLAEQKLLEWVKKYPINS... | 99 |
A0A1Y1I713 | 2.4.1.18 | ACT_SITE 490; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 545; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MATSRVVQLGGRWSELTRTSGVDRLHCGPVCSIPVSLHRPEHVAWSNTFACQNESLKPLAKRTKAGKNAARQGARAQVSRTKVTDAAKAAKDLKETIKASEEKLETLQGDDAAVADLESETARIEREIDSLKQENAKLRVKVTGEAGPMAAPSVMPPPGEGQEIYKQDPFLEPYRDHLEYRYGQYKKWRGEIEKYEGGLEAFSRGYEKLGFTRSGKGITYREWAPGAKWASLIGDFNNWNTNADVMTKNEFGVFEITLPDNADGSPAIPHGSRVKIHMDTPSGWKDSIPAWIKFAVQAPGEIPYNGIYYDPPEEELYKFK... | 73 |
A0A8M3B3R5 | 2.3.2.26 | ACT_SITE 800; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MKAQLQITVLSAKLRENKKNWFGPSPYVEVFVDGQSKKTEKCTNTHSPKWKQSLTVIVTPFSKLIFRVWSHQTLKADILLGVASLEVSETLKANNMKICEVVQTLQLSSDRGRSEQVGDLSLCLDGLQVDAETFASEEQKHNAVVNGESRLNGDAIRSRDSSPSSDITDDAPLPNGHAVGSSASASPSTGALRAPRPLRPQRPPPASPHKHTSSTASSTGSTPTHGSSAPSPEMSPRVCVNGETESQGSSSGSGSNQAPRASPTPPRAPAITNGPLPPGWEQRADQNGRVYYVDHIEKRTTWERPEPLPPGTTTWQRPTL... | 65 |
Q6F3A6 | 2.7.11.1 | ACT_SITE 257; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNTCVGPSISKNGFFQSVSTVLWKARQDGDDALPGANGAPDGGGQGRLPAPPPPTSDAPLAVQNKPPEHVKIVSTTDTASAEQDASKSSAGSDSGEAARPRPRVPPVKRVSSAGLLVGSVLKRKTESLKDKYSLGRKLGQGQFGTTYLCVERATGKEFACKSILKRKLVTDDDVEDVRREIQIMYHLAGHPNVISIRGAYEDAVAVHLVMELCAGGELFDRIVQKGHYTERKAAELARVIVGVVEVCHSMGVMHRDLKPENFLFADQTEEAALKTIDFGLSIFFRPGQVFTDVVGSPYYVAPEVLKKKYGQEADVWSAG... | 99 |
Q386E7 | 6.3.4.4 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 105; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125" | MAAAPSATAPKHNYTLGTNASQLELYKYLKTVPPIPELRQAVTIKKYEEASVDDTLYPLIDEHQIIMVVGAFFGDEGKGKTVDAVARHPACTCVARVNSGENAGHTVFDDIGRKYVFNLAPSSLLTPNTRNYVSSECVMDPISFMEREIGQFIKSNMPYKDKLFVGNVFVVTPYHKLLDLLGSAPNSSTLKGMSPIHASKVTKRGIRLDHIFNDEGVLRARLAKDMDTYYGLLKVKGLTDKDVVRRCQEENADGVERVPGYVVDFARAENKIDYLVKLYTERVKNNKDFPRRCDVTHELRAALARGEKLLLEGPQSYWLS... | 253 |
Q5Z7L0 | 3.2.1.23 | ACT_SITE 178; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 247; /note="Nucleophile"; /evidence="ECO:0000255" | MSGGAVAFLLLVAAAAVANAAVTYDHRSLTINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPVQGQYYFSDRYDLVRFVKLVKQAGLYVNLRIGPYVCAEWNYGGFPVWLKYVPGISFRTDNGPFKAAMQTFVEKIVSMMKSEGLFEWQGGPIILAQVENEYGPMESVMGSGAKSYVDWAAKMAVATNAGVPWIMCKQDDAPDPVINTCNGFYCDDFTPNSKNKPSMWTEAWSGWFTAFGGTVPQRPVEDLAFAVARFIQKGGSFINYYMYHGGTNFDRTAGGPFIATSYDYDAPIDEYGLLR... | 163 |
A0A1Y1HWB2 | 2.2.1.1 | ACT_SITE 502; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MQAVQASSLASAGATFAAAAAGVSSQKNVQMSAPVCRRSATKASLGNFAGLRRVSESRSETAAFSQPAAVKRSAKKQGIRATAAVKAPSKVSPEVVDKSINAIRFLAIDAVEKANSGHPGLPMGCAPMAYVLFNETMKFNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDSVKTEDLSQFRQWGSKTPGHPENFETPGVEVTTGPLGQGIANAVGLALAEAHLAARYNKPDAKVVDHYTYCILGDGCNMEGISNEAGSLAGHWGLGKLICLYDDNKISIDGHTDIAFTEDVQARFDALGWHTIHVEEGNTDLDALRK... | 51 |
Q89EM1 | 6.3.4.4 | ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MANVVVVGAQWGDEGKGKIVDWLSEQADIVVRFQGGHNAGHTLVINGKTYKLALLPSGVLREHKLSVIGNGVVFDPAAFLDEVTKLRAQGVAVSPENLRVAENVTLILPLHRELDAHRESANAATAIGTTRRGIGPAYEDKVGRRAIRLMDLADLDTLPHKIDRLLAHHNALRRGLNLPEFDGKDILKELTALAPQLLPYAETVWRLLDIKRREGKRMLFEGAQGALLDVDHGTYPYVTSSNTVAAQAATGSGLGPGAVGYVLGLCKAYTTRVGQGPFPTEQDNEIGRKIGERGREFGTNTGRPRRCGWFDAVLVRQAVR... | 253 |
F6R2Y1 | 2.7.10.1 | ACT_SITE 967; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MRHCYPIVVLLVVLCLNIQTTESTSECDNVVCPEQVICQPPKTKLVLPYPGKEKCCVKVVCTCKGTNSELTSSGSREIQYSNLEKLYTNCTLVNGNLELTGLFPFGNITTIEFTKHIEQVTGYLLIYRTIMDSINLSSLRLIRGLTQYYIGVDCRTNLTLARDQPGYSVYANRITGDQNYLRELWMPKLTEISAGNVFFTKSRICNLESIKWRDEIFNDGSQTVEITNDPVRDRYCDPCPSVCRDDSGSTPVNRCWGNSSDLCQLITKSKCRRQCGNDRCNAGGACCNGKCAGGCYDNMPATGNKDKWCHACKDMNNNGT... | 97 |
Q59Y21 | 2.3.2.26 | ACT_SITE 800; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MAPNISTSRSNNNTTTINVKVVAAESLYKRDVFRQPDPFAVLTVDGSQTKTTITAKKTLNPYWNETFNFQAKEDSILVIQVFDQKKFKKKDQGFLGVINVRIGDVIDLSLNSSEETITRDLKKSNENLAVSGKIIVVISHNRNSNGGGVTTATTRGTGASSSNNIATITSGVNNLRIGSATTTANSTAQASSDATVGANGSGPTSSLPPIGQGHPETAATPGGAAGAAGAASRQYSSFEDQYGRLPPGWERRTDNFGRTYYVDHNSRTTTWQRPALHQSETERGQQRQSETEAERRQHRGRTLPGEGSVSPLPTGSGNSI... | 65 |
O55234 | 3.4.25.1 | ACT_SITE 60; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P28074" | MALASVLQRPMPVNQHGFFGLGGGADLLDLGPGSPGDGLSLAAPSWGVPEEPRIEMLHGTTTLAFKFLHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGTAFSVGSGSVYAYGVMDRGYSYDLKVEEAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHDKYSSVSVP | 180 |
A0A022RTI0 | 3.2.1.52 | ACT_SITE 338; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MGYFSNLLISTILLSCTIWSISILQISAVRFPINVWPKPTTFHWPHPQAIPLSPKFIISAPRHHRHLSAAVHRYLRQILTEHHRPLVSPPLNLTSSPPLKTLKITVADTAAALAHGVNESYTLEIPSTGAAAVLTAETPWGAMRGLETFSQLVYSKPSVVACGLRISDAPLFAHRGVLLDTSRNYFELDDLLRLIRAIGMNKLNVFHWHITDSHSFPLVTPSEPELAAKGAYGEAMKYTAADVKKVVQYGMEHGVRVVPEIDMPAHTGSWAEAYPEIVTCANEFWWPIESEWSDRLAAEPGTGQLNPLNPKTYQVVKNVI... | 170 |
Q7VRT4 | 2.2.1.2 | ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MNQLDNLKKFSKISADTGDVDLIRTYQIQHATTNPSLILKSPLFTTYLKLFNDAIDYAQKIGGNQNTKITNASDRLIVNIGSEILANISGYISTEIDAQLSFNTDLTIKKAHKLITMYQKKNIDTSRVLIKIAATWEGIQAAEELEKSGIKCNLTLVFSFAQARACAERNIYLISPFIGRIYDWYNQRNLIKTSYINDDPGIQSIKKIYHYYKTYGYNTIIMGASFRRLEQILALSGCDYLTISPHFLKQLYQNTNSVTRQLFPPKTIISHHIPVLDQSEFFQEHNKNQMAVEKLNEGIQQFSIDQQKLHKLLLNNLNVQ... | 52 |
A0A061G6S9 | 3.1.1.11 | ACT_SITE 224; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTGKRSRNIEVGAAICTILVLAPVVLSQNSSPIPVDKSQLKAWFNANIKPASARGSTIDPALAKAEVAAHIIKVKKDGSGDFDTITKAIASVPSGNTKRVIISIGGGSYREKIRIDRSKPFITFYGDPRNMPNLSYDGTARQYGTVDSATLIVESDYFVAANIVIQNTAPRPDGVMVGAQAVSLRISGDKAAFYNCKIIGFQDTLCDDRGNHFFKDCYIRGTVDFIFGSGKSLYLNTVLYVDGQKGVTVITAQARESSSENTGYSFVHCTVTGTASGAYLGRAWKTSPRVVFAYTNMSSVIHPLGWSDNLHPERAKTVFF... | 125 |
Q9RXK9 | 2.6.1.16 | ACT_SITE 38; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164"; ACT_SITE 637; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000256|HAMAP-Rule:MF_00164" | MAVRGAVPRWTFPFRPGAEAESSGRGKAPTHARGAFMCGIVGYIGPRQAQDVLLSGLSKLEYRGYDSAGVAVGDGACIAVRKKAGKLANLAGDLQAAPLSGSFGIGHTRWATHGLPNDRNSHPHTTEDGRIVLVHNGIIENYLPLKEELLARGHTFKSDTDSEVVAHLIEEAYQGNLEEAVQAALAQVRGAYALVVTHVDHREIVAARTVSPLVMGVGEGEMFLASDVPALLAYTRQMVFLMDGDMVILSDDGYRVTDLQGHPVQRDVETIEWDAEAAEKGGFDTYMLKEIYEQPQALTNTLLGRLRDEQGAVDLDISLD... | 81 |
A0A1L8H7I8 | 3.1.3.48 | ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 311; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MSAMENGQDLAEQPVKKPKMQDSGEEGLSQVGNNESSDRKAEPSSNMSSNQTMPSEILPCADYILRANDYASQIYPAKSYTHILSVPVAETVATYTGQTQYQTLQPSQPYTVYPQASPTYGLPPFGALWPGIKSESGLIQTPSPPAALTSSGVTSSQSSPVLYSYPVQASSTNASAMSSPSTIANISIPTVTSISSQEYPSYTILGQNQYPQCYPNQGFPSAASSSNAEANSATPLFPTDKSENTVPAQASQRPLADNAAGQPMMRAMGSQETEEQNKKAVPVKNRGKGKKADASSPQHGDLERVFLWDLDETIIIFHSL... | 149 |
A0A0A0K7I0 | 1.11.1.7 | ACT_SITE 91; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLNGWVVSVLFITLLVSLCNPRGVSDIKTLHFSETHTNTHTHTLFSFLSTLQYDFYRKSCPNAENIVRSSVANIYSHHQDISASLLRLFFHDCFIQGCDASILLDPITGDATYSTEKQAIPNLTLKGFHEIDQIKEELERVCPRVVSCADILSLATRDAVVLAGGPFYPVFTGRRDSTRAYFEEATADMPRPDDSINRTLYLFATRGLDERDMVSLLGAHNIGKIGCQFILNRLYNFSGTNLPDPSIDPEFLNHMRSKCQEKENNENNNGSQDQMSPASSPISKEASVEKLRRSTLDVSNFQELSSALSLEGGFDTHYYK... | 14 |
A0A804K0W1 | 3.1.1.11 | ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MALLGHVTVSQRSTIQHQDFISWDDLSVEKYTRTMDAVDGDATRVILVSKDGTGDSRTVQGAVDMIPDGNKERVKILINPGVYREKVIVPKTKPFVSFIGNQSSETVISFHLRASDRYSNGQNVGTFDSATVAVESDYFCANGITFENTAPAAQPGEEGMQAVALRLTGDKAMIYRCRILGSQDTLFDHYGRHYFYECYIQGSIDFIFGSARSLYQACTLHAVAESYGAVAASQRNSPMDNSGFSFLECRLNGTGLLYLGRAWGRYARVVYSYCQLEGIILPEGWNDWGDPSRKSTVYFGQFNCKGDGANLQGRVSWARS... | 125 |
A0A6I8NPM1 | 2.7.10.1 | ACT_SITE 719; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MLPWRRRRRWCRGPEPGMARLWGFCGLLVLGLWRGVRACPAPCICSATRIACGDASPGLVAFPRLEPSTADLENITEIYIANQRMLQVINAEDLEGYVGLKNLTVVESGLTFIARQAFLKTPNLQYINFTRNKLTSLSRKHFGHLNLFALTLAGNPFKCSCDIMWIKVFQETRSKKGSQDLFCINESNKKIALSDMLIPNCGLPSANLITHNLTVEEGRSLTLYCNTSGVPAPDISWDLNNLVSKHVVDTSKKLSSLSITGISPDDSGKQITCVAENIVGREQDSVNLTVHFAPTITFLEPPTSDHHWCIPFTVKGNPKP... | 97 |
Q57XW9 | 2.1.1.37 | ACT_SITE 313; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MCSVAPLASHGTGCPVAACIVRCKRHLSAVVCRLRKLKRLRSGRNVTTFNANFYEAVAEERRYGAFTDGEHFDDCTLHLRRWMLRRVTCAPTFATSVTGSVETNEVLTMWTKLSDGGVVWNILQKEQQCYAVHFIGELSSDFVKELFNCTVDEYRSGSHNGVVLCIVQQLRVYSEACCRPEDFPPPLYELRAAALRTQVLHQCGSAGAFPTSTKLGKRSENGSDCFTFSELFAGMGMFRVGLERIGGKCVFAVECAPHARSVYHANHHLPRRNSCGNEALPATRRPVPLVGDITTVPSHYFPHHDVLTAGFPCQSFAKAG... | 47 |
Q5U1S5 | 1.11.1.7 | ACT_SITE 104; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRRPDPATGLRFAAVSLILCTANICAVARRSSYALLLDDEEDGGGGGDGSASFSFFPQTQPRGLVYGFYDESCPDAEGIVSSTVRELYLANPNVAAALVRLFFHDCFIHGCDASVLLDRINGDKSEREAAPNQSLRGFGAVDKIKARLEAACPRTVSCADILVLAARDSLVLAGGPSYPVLTGRSDSARAFYDEVGARIPSPNATYTVTLDAFARRGFTERETVALLGAHSIGKVHCRFFKDRIDNFAGTGEPDDTIDADMVEEMRAVCDGDGAAPMEMGYYRQGREVGFGAHYYAKLLGGRGILRSDQQLTAGSTVRWV... | 14 |
Q814M9 | 3.2.2.27 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00148" | MENVLKNDWEPLLAPEFEKEYYLTLSSFLTEEYSTHVVYPKVEDIFNALQYTSYENTKVVILGQDPYHGPNQAHGLSFSVQPGVKTPPSLLNMYKELRDEYGYEIPNNGYLVKWAEQGVLLLNTVLTVRQGEANSHKGKGWEHFTDRVIELLNEREKPVIFILWGRHAQAKKKLITNPNHHIIESVHPSPLSARRGFFGSKPYSKINTILANMGEREIDWEIPNL | 173 |
Q9VVI3 | 2.3.2.26 | ACT_SITE 974; /note="Glycyl thioester intermediate" | MSARSSGLVAAAALPVPSSSSSVAGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVNDSGDSCHLRIVVLTGQSLAKKDIFGASDPYVRIDLNTINGDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYTLRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQLASDFQRRFHISVDDTESGRSADSISHNS... | 65 |
A0A072TK22 | 3.1.1.11 | ACT_SITE 223; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVSKTRTYMINVAIIVALFMVNVALSDDTIPVPANRAQVDSWFNTNVGPLEQRKSTLDPALVTAEAGAKVIKVMQDGSGDFKTITDAINSIPTGNTVRVIVNIGGGSYNEKIKIDRTKPFVTLYGAPGNMPNLTYGGTAKQYGTVDSATLIAESDYFVAANILVSNSAPRPDGKTAGGQAVALRISGDKAAFYNCKFFGFQDTICDDRHNHIFKDCVIQGTVDFIFGSGTSLYLKSELRALDDTGPTVIVAQARKTASDADLYSFVHCDITGTGSSTFLARAWMTYPKIIYAYSTMTNVVNPKGWDNAMHPEFDKTSYFG... | 125 |
H3GHX8 | 5.4.99.12 | ACT_SITE 79; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001430-1" | MSGHRRLNMPPSAFLRVDAAGPWIRRRCVVEYDGADFCGFQAQDQPGAMRTVQETIEDALGRTTGEMPLPRLRFASRTDTGVHALGQVVVFASRCAESDRVLRDALNTRLPKDVLCRSLVTMTEAEADFDPCADAKRKRYEYELIAGGLRPVAHRRNVWHVRKPLDVASMQAAVEQLMAPPTTKDFSSFTPQKSVDSDRGNVCTVSAIELHAEKLDGRGDAQYEDDVATRIRLVFEGNRFRYKMVRNLVGTIVDVGLGRLSPDDIPAILAAKNRGNAGQGAPPQGLTLVWVKYD | 217 |
Q8ZBP3 | 2.7.1.25 | ACT_SITE 121; /note="Phosphoserine intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00065" | MPAHQLDDHNQETRSDDENIVWHPHAITRQDREQQHGHQGVVLWFTGLSGSGKSTLAGALEQALFARGVSTYLLDGDNVRHGLCRDLGFSDADRRENIRRVGEVAKLMVDAGLVVLTAFISPHRAERKMVQDMLASGQFIEVFVDTPLAICEARDPKGLYKKARAGELKNFTGIDSVYESPASPDIHLQGEQLVTNLIEQLLDVLRGRAIIKS | 90 |
A0A8M2BDT6 | 2.7.10.2 | ACT_SITE 696; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | MGFAEDLWCPQGHAALMKLQDSELRLMEVMKKWMMQRAKSDREFSMQLHQMSAMVEKMEGTQPGGGLNYISQFNKSWNVLVSQTESLSRIMRKHSDDLMVGPLSKLTLLIRDKQQLRKTYGEQWTLLNQDMCRVTQTELDRLKSSYRQLVRDATYAKKKYQEASKDRERDKAKERFIKATLKLHEHHNEYVLSVKAAQVHHQLHYGQSQPALLGALQTLQEEMVLILKEILQEYFDLSSLIQDEVVSVHTEMANALKAIQPHKEYDNFIQQNRSRGEVPACVEFDCSLLEEADALEPEDLQLNELTVEGIQHRLTAVEEE... | 98 |
P12688 | 2.7.11.1 | ACT_SITE 470; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MYSWKSKFKFGKSKEEKEAKHSGFFHSSKKEEQQNNQATAGEHDASITRSSLDRKGTINPSNSSVVPVRVSYDASSSTSTVRDSNGGNSENTNSSQNLDETANIGSTGTPNDATSSSGMMTIKVYNGDDFILPFPITSSEQILNKLLASGVPPPHKEISKEVDALIAQLSRVQIKNQGPADEDLISSESAAKFIPSTIMLPGSSTLNPLLYFTIEFDNTVATIEAEYGTIAKPGFNKISTFDVTRKLPYLKIDVFARIPSILLPSKTWQQEMGLQDEKLQTIFDKINSNQDIHLDSFHLPINLSFDSAASIRLYNHHWIT... | 99 |
A0A1U8AGW5 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEVHSILFRTLPQAFFLLLIINLATTPYGYVQGQGTRVGFYSKSCPQVETTVRSTVQSHFRSDPTIAPGLLRMHFHDCFVQGCDASVLIDGPSTEKTAPPNQLLRGYDVIDDAKTQLEAACPGVVSCADILALAARDSVVLANGPSWQVPTGRRDGLVSRASDTTTLPGFTDSIDVQKQKFADQGLNTQDLVTLVGGHTIGTTACQFFRYRLYNFTTTGNGADPTIDSNFLPQLQALCPPNGDGTRRIGLDTGSSDRFDGSFFTNLRNGRGILESDQKLWTDPSTRTFVQQFSGPIRGLLGLRFNIEFGRSMVKMSNIGV... | 14 |
A0A8V0YDQ1 | 2.3.2.26 | ACT_SITE 893; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MATASPRTDTSNNHNGRLQMQVTVSSAKLKRKKNWFGTTFYTELTADGEIKKTAKSSSSSNPKWDEQLTVNVTPQTTLEFRVWSHHTLKADALLGRATVDLRQALEIHNRKLDKVKEQLKLSLENKSGMVQTGELTVVLDGLVVEQESLTNLSSPATIEVQQNGEAVHENRDASARSTSRSACDVSNGNDNQVPSNSVVQNAFCIEAVNGNNSPSPTHIAARPKNTPVPKPLGAELVNSTVNGETSSSAPETGNSSVSEAMVGSEEAPMSTDCTNTTAEPQSTEEAASCSESHTSALSVASAGLEASTTTDCAQPNTSTA... | 65 |
A0A022RGU0 | 2.2.1.1 | ACT_SITE 490; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MAAMAMSSLLLHPNSGHHKRPIYKITKLPSRKPFSCKSSLLNPTKIQDQNYKLSWINEIQEAYPSAAAGGEYSDEEFQELVDRRCVDNVRMLIVDSVQRAKAGHPGMALGMADVAYFLYRHVFRHNPMNPTWFNRDRFVLSAGHGCLLQYVCLHLAGFHSVKIEDLQRLCQLGSRTPGHPENTVTAGIEVTTGPLGQGVANAVGFALAEAHLAARFNKPDVAIVDHRTYCIMGDGCAMEGISNEAASLAAHWKLNKLTLIYDDNKNTIDGPTDLAFTEDVTLRFKALGWNTITVDATHSNMSSFKNALLDAFNETQRPTL... | 51 |
Q89BN9 | 3.5.1.88 | ACT_SITE 141; /evidence="ECO:0000255|HAMAP-Rule:MF_00163" | MALREIIILPDKQLRLVSKPIEKVTTEIRKLADDMFETMYDAPGIGLAAIQIAQPLRLITMDLAKRDENGETKPEPRVFINPEVIASSEELSVYEEGCLSIPEYYEEVERPAKVRVRFTDLDGKVHEEDAEGLYATCIQHEIDHLNGVLFVDYLSKLKRDRVLKKFEKAAKRAE | 183 |
Q9FIF0 | 2.7.11.1 | ACT_SITE 500; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAGVLRSLRFWMIICVQVLSLVLAQDRDEFVYHDFSQADLHLDGMASIDDGRLHLTNNTTKSTGHAFWKIPMNFTTSPSSSLSFSTEFVFAIFPLLGDGQGMAFVVAPFMDIRYSGDAASYLGLFNRKNDNKTENHILAVELDTNSSPEAIEDSDNHVGIDINSIISEDSANASYFSGTEGKNISFRLASEKSILVWIDYNGTEKLLNVTVAPVPTPKPALPYLSSSIKPRKPLLSRFINISEIFNGTMFVGFSGSTGTVKSDQYILGWSFKKGGQAESLDLSKILDPPNRPPPPSSPPPPPPPPPTPPTSRSKDSKNII... | 99 |
Q8A9Z8 | 3.4.21.89 | ACT_SITE 39; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 112; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MKRALKKFGWALLGLFILFQIYFSVRVYWLVSCTIPTYSMSPTLVGGDYILVSVQIPGRRIYKKDPLRPEHYLIHRRKGAHGVKKGDVVVFNFPYAKQNEKMILCDEVFYCKRCVALPGEIYQWRTNEGTKTVYLPKINDTIRIDTTNYSDYYKCIEYETGLPVRVSEEGKVYLANTLLESYCFRHDYYFMRGDNVNDSYDSRYWGVLPDDFILGVGKCIWFSRDPKTKQIRWNRIFKTI | 178 |
Q9SFX0 | 2.7.11.1 | ACT_SITE 201; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MRCFSCLNTQTNDMRINIDTLSDLTDYASVATKIDPRGTGSKSGILVNGKVNSPKPGGGARSFTFKELAAATKNFREGNIIGKGGFGSVYKGRLDSGQVVAIKQLNPDGHQGNQEFIVEVCMLSVFHHPNLVTLIGYCTSGAQRLLVYEYMPMGSLEDHLFDLEPDQTPLSWYTRMKIAVGAARGIEYLHCKISPSVIYRDLKSANILLDKEFSVKLSDFGLAKVGPVGNRTHVSTRVMGTYGYCAPEYAMSGRLTIKSDIYSFGVVLLELISGRKAIDLSKPNGEQYLVAWARPYLKDPKKFGLLVDPLLRGKFSKRCL... | 99 |
Q9M4A2 | 5.6.2.2 | ACT_SITE 103; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01385, ECO:0000269|PubMed:17965269" | MEGKFAISESTNLLQRIKDFTQSVVVDLAEGRSPKISINQFRNYCMNPEADCLCSSDKPKGQEIFTLKKEPQTYRIDMLLRVLLIVQQLLQENRHASKRDIYYMHPSAFKAQSIVDRAIGDICILFQCSRYNLNVVSVGNGLVMGWLKFREAGRKFDCLNSLNTAYPVPVLVEEVEDIVSLAEYILVVEKETVFQRLANDMFCKTNRCIVITGRGYPDVSTRRFLRLLMEKLHLPVHCLVDCDPYGFEILATYRFGSMQMAYDIESLRAPDMKWLGAFPSDSEVYSVPKQCLLPLTEEDKKRTEAMLLRCYLKREMPQWR... | 222 |
Q54S77 | 2.7.11.1 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGNTVGAPIVSEYLEDEIGPIVFKKSLGNARFLKTVKAYHSEEGYVVVKIYKKRNTKESLEKYKIMLKEIKDNFNITPSFNIMPYQHFIETDRSGYLIRQYFHNNLYDRLSTRPFLSMIEKKFIAFQLLKALEQSSFKGVFHGDIKSENVLVTTSNWVYLSDFACYKPTFIPEDNPADFSFYFDTSGRRTCYIAPERFYETNRGAPSNNELTPKMDIFSLGCVIAELFLDGFPIFDFSQLLSYRKGEYSPEPIIRQRIQDPNIQTLILHMIQKDPDQRYTPEKYISKWNTVFPQYFSFAHQFIPELMRLENDDRVMCISD... | 99 |
A0A078HB81 | 1.11.1.7 | ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASPFSSCKQKHAFLSSLLLFLPLLLLISSSVADLSFNFYGSSCPGAEFIVRNTVRSASSSDPSVLGKLLRLVFHDCFVQGCDASVLVRGNSTERSDPGNASLGGFDVIESAKNVLEIFCPGIVSCADILVLAARDAVEALGGPVVAIPTGRRDGTVSAAENVRPNIIDTDFTVDKMINIFASKGLSVQDLVVLSGAHTVGAAHCNTFNSRFTRDPRGNFELIDASLDNSYAQTLLNKCSSSMDPTTTVVNNDPETSSTFDNQYYKNLLAHKGLFQTDSALMEDDRTRKIVEILANDEESFLERWTESFMKMSVIGVRVG... | 14 |
Q6NUA1 | 2.1.1.320 | ACT_SITE 431; /note="Proton donor/acceptor"; /evidence="ECO:0000250"; ACT_SITE 440; /note="Proton donor/acceptor"; /evidence="ECO:0000250" | MAAGDGGRVSSGRDVACVTEVADTLGAMANQGFDFLCMPIFHPRFKREFYKEPAKSRPGPQTRSDLLLSGRDWNTLIVGKLSDWIKTDSEVSRIRKTSEAAMQQELNFSAYLGLPAFLIPLKQEDNSNLSRLLINHIHVGHHSTMFWMRVPLMAPNDLRDDLIENEPISLSEEDNSGEERTWIWWHNFRSLCDYNKKIALAIEIGADLPSGHVIDRWLGEPIKAAFLPTSIFLTNKKGFPVLTKVHQRLIFKLFKLEVQFVISGSHHHSEKDLCSYLQYLEYLSQNSPPPNAYEMFAKGYEDYLQSPLQPLMDNLESQTY... | 44 |
Q9I4I2 | 1.17.4.1 | ACT_SITE 194; /evidence="ECO:0000256|PIRSR:PIRSR000355-1" | MLSWDEFDKEDPTEAKAAPAAAQAVAQGHDKLDDEAAGSVEEARAVSADDSDAVARAKKALNDLDIQEGLDDLEGSAARVQVGDKQMINARADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSKDGLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVAKKASWGLKYTRSISDPMFQTGTPETDRQFLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQM... | 21 |
A0A251UDN0 | 4.1.1.50 | ACT_SITE 64; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 78; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 232; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAVSGFEGFEKRLELEFSCHDPVIGIGLRELDFKSLEQVLHLVQCTVVSALGNQHFDSYVLSESSLFVYPTKIIIKTCGTTQLLKSVQPFIHLARTLNLHIVALRYTRGSFIFPQAQPHPHTSFHEEVVYLEDNIPANLCYRKASVIPSKLTSHSWHVFSAAVVEYSDDILYTVEVCMTDLDQTLARKFFRHPNDGKNGDSAGREMTEATGINRINPNAQICDFAFDPCGYSMNAIDGDRYSTIHVTPEDGFSYASFECVGSVYDGDIADMVKKAVKVFCPGTVSVATTSASNDMCLRMKNAVEQLGMKCRSWSMDEFPA... | 196 |
B9T8H9 | 3.2.1.14 | ACT_SITE 135; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MLTRHLLTITALATILAGALLPKNVMGQNCGCSPGLCCSQYGYCGSGKDYCGPGCRQGPCFAAPGNNAVSVPDLVTPDFFNRIINQAAPSCPGKNFYTRKAFLEALNSYSGFGKIGSSDDSKREVAAFFAHVTHETGYFCYREEQNTGDKSFCDPSYRDYPCTPGKRYYGRGPIQLTWNYNYGAAGRSNNFDGLNNPEIVSQNPVISFKSALWFWMNNVHSRVTQGFGATIQAINSGECGGKETRKVQARVDLYTKYCSQFGVSPGGNLYC | 158 |
Q9KPB2 | 3.1.26.3 | ACT_SITE 44; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 116; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MTPPMNKLTSKLGYTFKETELLNLALTHRSANGKHNERLEFLGDSILSFVIADELYRRFPKVNEGDMSRMRATLVRGNTLAELGREFDLGDYLKLGPGELKSGGFRRDSILADAVEAIIGAIYLDSDLETARSIVLEWYHGRLEEIKPGASQKDPKTRLQEFLQGRRKPLPVYTVTNIKGEAHNQEFTVACEVAGMDTPVIGKGTSRRKAEQAAAETALEQLTNG | 138 |
T1FZQ7 | 3.5.1.23 | ACT_SITE 95; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR017632-1" | YHIDLDLAPQNRWDDLAFHEGAKLKKILQVFKDVLLSFSKYSANIISFVDNNLGQLVDTLPQPYRDELKGLANATNLPLGEVLLYNLFYEVFTVCTSILAEDDRGNLYHARNMDFGLFMGWDSQNSTWLMTEALKDSVVNLKWKKNGQVLFKSVNYVGYIGVFTAMKPGAFSLTVNERFNIDGGYLGILKWLLGYRQSSWLTFITRQVMETARDFHDAYYLLRDKELLAPVYFILGGNQTDQAVVITRSRLEAIDVWHLSMDNSTFYLLETNYDHWSKPPFYDDRRSVGRKCMDGLTKKNVGFLGLFDVLSSKPVLNKLT... | 182 |
A8HYD8 | 3.4.19.12 | ACT_SITE 78; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 155; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MEWTTIESDPGVFTELIENIGVKGVQVEELWSLDQLRELSPVFGLVFLFKWKKEPVRPATTTDAGQVFFAKQVISNACATQAILNILLNVKAPGLDLGTELANLREFVSDFDPTMKGLAISNSDLIRTAHNSFARPEPLVPDNDKDDEKSGDAYHFISYVPVGGKLFELDGLQEGPIELCDCTDDDWLDKVGPHITARMERYAASEIRFNLMALVGNRVDIFSSRLAAATAQRDQLAAAAAAADGMSDEDLAHAQAKLLEAETEVANLQEALAAEQAKHRTWHEENVRRKHNYVPCLFQLLKLMAARGQMGPLLERARRP... | 175 |
Q9SCV8 | 3.2.1.23 | ACT_SITE 185; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 254; /note="Nucleophile"; /evidence="ECO:0000255" | MVLNFRDKSCIFLAILCCLSLSCIVKASVSYDRKAVIINGQRRILLSGSIHYPRSTPEMWPGLIQKAKEGGLDVIETYVFWNGHEPSPGQYYFGDRYDLVKFIKLVHQAGLYVNLRIGPYVCAEWNFGGFPVWLKFVPGMAFRTDNEPFKAAMKKFTEKIVWMMKAEKLFQTQGGPIILAQIENEYGPVEWEIGAPGKAYTKWVAQMALGLSTGVPWIMCKQEDAPGPIIDTCNGYYCEDFKPNSINKPKMWTENWTGWYTDFGGAVPYRPVEDIAYSVARFIQKGGSLVNYYMYHGGTNFDRTAGEFMASSYDYDAPLD... | 163 |
Q8P9Y6 | 2.1.1.77 | ACT_SITE 75; /evidence="ECO:0000255|HAMAP-Rule:MF_00090" | MTPRLRLQPESVGIGMTSQRVRDRLVERLRESGIQDEATLNAVRTVPRHLFIDEALASRAYEDTALPIGHGQTISQPWVVARMTEAVLQVAPKKVLEVGTGSGYQGAILAALGLEVYTVERIGDLLRQARKRFRHLGMNVRSKHDDGRIGWPEHGPYDAIVVTAAAPALVDALVDQLAVGGRLVAPVGGASSQSLVQLTRGADGEIAQEVLAPVTFVPLLSGMLD | 49 |
Q00216 | 5.3.4.1 | ACT_SITE 49; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 52; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 169; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 172; /note="Nucleophile"; /evidence="ECO:0000250" | MVRLSNLVSCLGLASAVTAAVVDLVPKNFDDVVLKSGKPALVEFFAPWCGHCKNLAPVYEELGQAFAHASDKVTVGKVDADEHRDLGRKFGVQGFPTLKWFDGKSDEPEDYKGGRDLESLSSFISEKTGVKPRGPKKEPSKVEMLNDATFKGAVGGDNDVLVAFTAPWCGHCKNLAPTWEALANDFVLEPNVVIAKVDADAENGKATAREQGVSGYPTIKFFPKGSTESVPYEGARSEQAFIDFLNEKTGTHRTVGGGLDTKAGTIASLDELIASTSAADLAAAVKKAATELKDKYAQYYVKVADKLSQNAEYAAKELAR... | 215 |
Q9SJF0 | 3.1.3.16 | ACT_SITE 787; /note="Proton donor"; /evidence="ECO:0000250" | MDEDSSMVADNDQDREFQSLDGGQSPSPMERETPQQMNDQSPPPEGGSVPTPPPSDPNPATSQQQAAAVVGQEQQPALVVGPRCAPTYSVVDAMMDKKEDGPGPRCGHTLTAVPAVGDEGTPGYIGPRLVLFGGATALEGNSGGTGTPTSAGSAGIRLAGATADVHCYDVLSNKWTRLTPFGEPPTPRAAHVATAVGTMVVIQGGIGPAGLSAEDLHVLDLTQQRPRWHRVVVQGPGPGPRYGHVMALVGQRYLMAIGGNDGKRPLADVWALDTAAKPYEWRKLEPEGEGPPPCMYATASARSDGLLLLCGGRDANSVPL... | 144 |
B8BT26 | 1.1.1.8 | ACT_SITE 218; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | EQICIVGSGNWGSAIATVLGRNAGRLSFCHDTVNMWVFEEDVDVTSDDGTTKLEKLSEVINTRHENVKYLPGIKLPSNIRAVPNLADACRNATLLVFVLPHQFLPKLLPTIRASVHPSCCRGVSLIKGLEFNETTKMPLLISKTIEDQMGGGFKCGVLMGANVANEVAMGRICESTLAGCFGNDELNEQTRRIFDEPPNFHVARIADVAGAEACGALKNVVALGAGFVDGLGLGGNTKAALLRVGLLEMAKFCAMFFDGVEQNTFMQSCGVADLITTCYGGRNRKCAEEFTKRRLQNDWMAQELLNGQKLQGTHCCKEVY... | 7 |
O75951 | 3.2.1.17 | ACT_SITE 54; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680"; ACT_SITE 71; /evidence="ECO:0000255|PROSITE-ProRule:PRU00680" | MTKALLIYLVSSFLALNQASLISRCDLAQVLQLEDLDGFEGYSLSDWLCLAFVESKFNISKINENADGSFDYGLFQINSHYWCNDYKSYSENLCHVDCQDLLNPNLLAGIHCAKRIVSGARGMNNWVEWRLHCSGRPLFYWLTGCRLR | 160 |
I1JB12 | 3.5.1.98 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MESGGNSLPSGSDGVKRKVSYFYDPEVGNYYYGQGHPMKPHRIRMTHALLAHYGLLQHMQVLKPMAAKDRDLCKFHADDYVAFLRGITPETQQDQLRQLKRFNVGEDCPVFDGLYSFCQTYAGGSVGGALKLNHGVCDIAINWAGGLHHAKKCEASGFCYVNDIVLAILELLKIHERVLYVDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGTGDIRDIGYAKGKYYSLNVPLDDGIDDESYQSLFKPIMGKVMEIFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVRYMRSFNVPLLLLGGGGYTIRNVARCW... | 184 |
A0A9K3J918 | 3.1.1.11 | ACT_SITE 430; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAASKILISVISLLLVVGCVLGVVLLIVKSGKDENISTSTKTAESICKPTEYKEACNKAVEEVAKNSSATHEDYILASIRATADELQKSLKKASEAKKDLGDDKKESKRDLESCEKMIGYASDELQQVLKVVAETEAVSLAEQIDPILVWLTAIRSYQTTCVDEIQDKKLKKDMQKGLETSNELTFNAQKIVYNVLDILKDIGVDLSEVKVPSTGQRRLLDEVDELDHHGFPSWVPSVDRKLLGAKKGGGGGGKKQKPNGQGLFKTPPPPPLPPNPVPNAIVAQDGSGKFKSIKQALAAYPPNHQGRYIIYIKAGTYSEG... | 125 |
A0A251UL14 | 2.3.2.26 | ACT_SITE 815; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTLAEQQRIKRKLDDYVDDDLDLASSSSSSFVRMRKDDRNPNPQPQPQNPIQFFVRTISGGTTLVLRGYPHDTIELIHRKIHSATGIPIMDQRLIYCGKQLQSEHTLSHYRITNDAGLHLVARMRSTGHPLVWQLVDDLVSVICRACRGVVGQGASTSIKLKLTEFLNMLPTTDDHDHDDDHDHNHNHNHRDRSAAPYLDIFLSSSAPAALVMLYFSPHPGNKECALDSVQHFIKSLPRLIYSQFAPILLDFCKLLRRAAFHDDPLYKLCRTSLASMVHYINLATRNSNASSYNNMAIALPDIFPFMNELATKLSQDLVS... | 65 |
F6RAB3 | 3.5.1.98 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | SNNKVAYFYDMDVSRFHYGPGHPMKPHRLALTHTLVLHYGLHNKMQMFKPYRATSHDMCRFHSEDYINFLQRITPMNLAGFTKNLKLFNVGDDCPVFPGLYDFCSMYTGASLQAATMLNNKKSDIAINWSGGLHHAKKYEASGFCYVNDIVIAILELLKYHPRVLYLDIDVHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEIGAESGRYYSLNVPLKDGINDQAYQQLLKPIMKAVMQSYQPTCIVMQCGADSLGCDRLGCFNLTIDGHGECVKFMKEFGVPMMVLGGGGYTVRNVARCWTHETSIIVGQEIN... | 184 |
Q7UFQ9 | 2.3.1.286 | ACT_SITE 111; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121" | MNVLILTGAGISAESGIPTFRDANGLWEGHAVEEVATPQGFARNPNLVHEFYNQRRRALLNPEIQPNAAHVALADFEREHLENGRGDFLLVTQNIDNLHQRAGSQNVLAMHGQLLQVRCVYSEEIFDWTGDLSVDTPHPEAPDDDSMRGCLRPNVVWFGEMPIGLTQIEKAATKADLFIAIGTSGVVYPAAGIVAQTPPHCRRIEVNLDDTPASSAFDETIRGAASVEIPKLLNHFSAM | 58 |
O04348 | 3.4.21.89 | ACT_SITE 184; /evidence="ECO:0000250" | MAIRITFTYSTHVARNLVGTRVGPGGYCFESLVRPRFFSHKRDFDRSPRNRPASMYGSIARELIGEGSQSPLVMGLISILKSTTGHESSTMNVLGVSSFKASSIIPFLQGSKWIKNPPVIDDVDKGGTVCDDDDDKESRNGGSGWVNKLLSVCSEDAKAAFTAVTVSILFRSALAEPKSIPSTSMYPTLDKGDRVMAEKVSYFFRKPEVSDIVIFKAPPILLEYPEYGYSSNDVFIKRIVASEGDWVEVRDGKLFVNDIVQEEDFVLEPMSYEMEPMFVPKGYVFVLGDNRNKSFDSHNWGPLPIENIVGRSVFRYWPPS... | 178 |
A0A2R6W794 | 3.4.21.89 | ACT_SITE 285; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 335; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MATKCVFSFCHINASPTSCVLRVRELMSVASTPGTDSRRAGRRGGCRSFSLRVACNDVKRKACYPSPWASWKENCKPELPKASSFVPGVLSSEFASSKFSVPGTQDFRGKTVKCSPLLSRVRAETSQRKQTFSSGSAQLFDSAPFSRSRQNQMAGHFRLPFVPSMKWLPCNEYMGSTFGSLLVSNAVRDGSNASHPNTEEPTSVSPGDGDGGGGGGGDEIGPSAKFQVKEDDAGEDATAENNKVSWLPDWVNMTSDDGKTIIAAFAASLLFRWFIAEPRYIPSLSMYPTFEIGDRIIAEKVSYYFRKPGVNDIVIFKAPP... | 178 |
Q9FX43 | 2.7.12.2 | ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MALVRERRQLNLRLPLPPISDRRFSTSSSSATTTTVAGCNGISACDLEKLNVLGCGNGGIVYKVRHKTTSEIYALKTVNGDMDPIFTRQLMREMEILRRTDSPYVVKCHGIFEKPVVGEVSILMEYMDGGTLESLRGGVTEQKLAGFAKQILKGLSYLHALKIVHRDIKPANLLLNSKNEVKIADFGVSKILVRSLDSCNSYVGTCAYMSPERFDSESSGGSSDIYAGDIWSFGLMMLELLVGHFPLLPPGQRPDWATLMCAVCFGEPPRAPEGCSEEFRSFVECCLRKDSSKRWTAPQLLAHPFLREDL | 108 |
D8SUV1 | 1.11.1.7 | ACT_SITE 38; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | GFYDQSCPSAESVVRRTMVDSFRRNPLLAAGILRLFFHDCFVRGCDGSVLLDRKPGGPIPEKESDVNNNSITGFRVIDDAKKRLERMCPGVVSCSDILALAARDAVWISGGPRWSVPTGRLDGRVSLATEADNEIPPPDLRIRDLRKAFLAKGLNTHDVVTLSGYSFTGAHTIGRAHCPAFEDRLYNFSATNAPDPTLNLSLLDSLQKICPRVGNTTFTVSLDRQTQVLFDNSYYVQLLASNGLLQTDQQLLFDASTAGLVRAYAADSSMFFRAFAKAMIKLSRVGLKAPGEGEIRKHCRRVN | 14 |
A0A0K9Q5H0 | 3.1.1.11 | ACT_SITE 365; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNLNRHLLHLFAVVVVLTASGILRSDARNGDYKREMKQWCETEVPYSHSCLMYTRRTYDGGGRMDRSVFFQFSLQAALSRAILAGADLRRMRKHSKYEENVWIDCEKLYSNTVIQLNRTVLSMEYSRPCDFQTWLSAALTNVDMCSKIFETDGDGTPDSMKMIASLSSLSKYNVPELISNCLAINEPLVLDNATANYKLTETMRRNLGSSVKADIVVAKDGSGRYNSVAAAVAAGTRMRRRKGKRLVIYVKSGVYSETVNIPNSMDDVTLIGDGKGKTIITGRRSVKSGYTMITCATVAVFGDGFVAKDLTFRNTYGPGS... | 125 |
P00722 | 3.2.1.23 | ACT_SITE 462; /note="Proton donor"; /evidence="ECO:0000269|PubMed:6420154"; ACT_SITE 538; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:1350782" | MTMITDSLAVVLQRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRDYLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPKLWSAEIPNLYRAVVELHTAD... | 163 |
B2UP57 | 3.2.1.52 | ACT_SITE 151; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:30846208, ECO:0007744|PDB:6JE8, ECO:0007744|PDB:6JEA, ECO:0007744|PDB:6JEB"; ACT_SITE 214; /note="Charge relay system"; /evidence="ECO:0000305|PubMed:30846208, ECO:0007744|PDB:6JE8, ECO:0007744|PDB:6JEA, ECO:0007744|PDB:6JEB"; ACT_SITE 279; /note=... | MARPLPILGGILLSFSPPAEATAQYSIIPEPSRTELRQETAKTLQLLSDQEVPTLETDAYRLTVTPQGAHLASGGREGRIYGLATLRQLRDQLAGQPEGIPCGVITDKPRYPWRGLMVDPARHFIPAADLKKFVDMMAYYKFNRLHLHLTDNQGWRLPVPGYPKLKSVASRREESFGDGIPHEGMYTKQELKELVAYCAARGIDVIPEIDMPGHNQALHAAYPEFFCFPKPDMNVRTTAGNSKELVCPQKPEVWKFYASVFNELKDIFPSGIVHLGGDEAPTELWEKCPLCREARTRAAMKDEQEQMKAFFAKTAALLAK... | 170 |
A0A0A0L8C5 | 2.7.1.11 | ACT_SITE 216; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MVTGGDNHFPFLVDDIPHFTHYLPPQHLKEHSNPLHNHPAYSTVDQYFVDVDDVVAENIVAGKKAQKRARYFRLAGPRQQVFFEPQEVHACIVTCGGLCPGINTVIREIVCGLHHMYGVHDVVGIQGGYKGFYSKNTISLTPKSVNGIHKRGGTILGTSRGGHGTSKIVDSIQHRGINQVYIIGGDGTQKGVAAIYEEIRKRGLKVSVVGIPKTIDNDIPVIDKSFGFDTAIEEAQRAIDAAHVEAESNENGIGVVRLMGRNSGFIAMHATLASRDVDCCLIPESPFYLEGEGGLFEYIEHCLKEQGHMVMVIAEGAGHE... | 84 |
P84199 | 2.7.11.1 | ACT_SITE 591; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTEEVGQKLLESLSLFKLGDIGYARIECELLTTFLEEQLENNLDSLSIHELSTNLIRNRICCREFIESRPAKKWVFLIFRLARTLFRDKTRIATFHSVNLHSEFVQVFWRNLTYQTKSYRNCKFQTFQFIASRFLRSEHDWNVTVVNCLNVTQKLIDNGENARKFVDCNLEDAVLVLLATRQMTVLQHSLEILGRLSDWSTTCRENLCESNTIDVCLQLIPDGDILTQKLCISLLRILSCEEQAREQIRIYDGVPTLLGLLSIKNSRLQWHVAWTLAQLAEQHETSLEIAQLGGISLIFAAISNPKPPGKAVGDWVAMLT... | 99 |
F1MZM9 | 3.2.1.35 | ACT_SITE 146; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MLRHQHISFRNFVGSNGAPQAVFTFLLVPCCLALNFTAPPLIPNIPFLWAWNAPTNHCAEIFSMPPDLGLFSLVGSPQKDVTGQPITLFYADRLGYYPKINERTGVHKNGGIPQVASLKKHLDKAEKDIAYYMPIDNVGLAVIDWENWRPTWVRNWKPKDVYKKASIELVLQQNRHFTLKEATKRAKADFEKAAKSFMQETLKLGKFLRPNHLWGYYLFPDCYNHHYNQANYNGSCFDEEKRRNDALNWLWKESTALYPSVYLNTKLKSSPQARLFVRNRVQEAIRLSKVANVKSPLPVFVYTRPVFSDMSSKFLSQDDL... | 166 |
A0DZI9 | 2.7.11.1 | ACT_SITE 234; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MHKISTSRSASQNRITLINKLSSPLHTQQDILDPKINSKELIEQLLKTIKRKPTQNEKPQKRIRSNANSGQKLVEINKNVLHIRDYEPEQQTVKKMHNKTILPKAQQISNYTMLQFLGKGKYSEVKLACEINTGIHVALKIMKKEQISSIWKSIAQELKIQYLLNHPNIVKLYTFFHTSTEIVLVLEYCCHGQLHKLLRSLTETCFTEKVAASYIKQVASALNYLHRNGIIHRDIKPENIFLCYNQIKLADFTHSIYSPQQERSTQCGSLAYISPEIVKGETYDKSTDMWSLGVLAYELCTGETPWEDLSFQEMQDMIIS... | 99 |
Q7NND8 | 2.7.1.23 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MPAFETVVIAYRAEEAHSRIAADRCESLLHKVGCRVLKGPTGPQDNPYPHFLEATGGHIDLAIVLGGDGSILAAARYLAAVDVPILAVNVGGHLGFLTQPPEVLGGRYWERLLAGEWELEKRMMLQASLTGPPPLPERQPYFCLNEFCLKPASEMRLTSIILELAIDGEIIDQIHGDGLLVSTPTGSTSYTVAANGPIIAPSLQAITITPICPLSLSSRPVVLPATGTIEVSPLRDPDLNIKLWSDGAFAAPVHPCQTVRIEVARHPTRLLILEEDHSYFRTLREKLKWAGTRIQAERDPECLLPPQNHP | 89 |
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