Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A2R6X7Q4 | 2.7.1.11 | ACT_SITE 311; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MASLSSAIASTLSRVPNFTEAERCGLQQHRCAREQPLSQITNVTQINCAVAVSCDGRSRTARLQRQVLLGPGRGGFWGSSLGFQTRRMALTRRTVHRACSRAQATDEAVLEDVPHVTDWLPDLPSFPNPLQDNPAYTAVKQYFVEEDDVVAKNVVVKLRTPGEGTHFRRAGPRQKVYFKPDEVRACIVTCGGLCPGLNTVIREIVCGLWTQYGVRDILGIDGGYAGFYSNNTIQLTPKLVNDIHKRGGTILGTSRGGHDKTKIVAAIQDRGINQVYIIGGDGTQRGAAVIYEELKRRGVKVVVAGIPKTIDNDIAIIDKS... | 84 |
A0A3Q2HPM4 | 2.7.10.2 | ACT_SITE 348; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630220-1" | MEAGTGWGRGAAGPARETATTSSGSRRGGCEAVEPETQELRPLLLHFSGQSPSDPVRGSSSSVEMPAARRFPGLELSFPLLARLRRRLYTRLGSSSMQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRLEAEFPAHHSQSTFRKTSPTPGGPAGEGPLQSLTCLIGEKDLHLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHF... | 98 |
I1MS29 | 3.1.1.11 | ACT_SITE 354; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAIPSLINQPQRTPSLTFSFLLFLAICTPLDAAHTDFAGSACLKVSPSHFAGSVTEVIAAIRQLASILSRFGSPLANFRLSTAIADCLDLLDLSSDVLSWALSASQNPKGKHNSTGNLSSDLRTWLSAALAHPETCMEGFEGTNSIVKGLVSAGIGQVVSLVEQLLAQVLPAQDQFDAASSKGQFPSWIKPKERKLLQAIAVTPDVTVALDGSGNYAKIMDAVLAAPDYSMKRFVILVKKGVYVENVEIKKKKWNIMILGQGMDATVISGNRSVVDGWTTFRSATFAVSGRGFIARDISFQNTAGPEKHQAVALRSDSDL... | 125 |
Q751G6 | 3.1.3.1 | ACT_SITE 106; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MATDEHTGLLPRVGGRSSKQRAVWGSLVALLVLATVVLRFDIVPRRAVAGGKRNVIFFVTDGMGPASLAMTRAYAQAQETDTQLRLPTFQMGSMQTRSSSSLITDSAAGATAFSCAMRTYNSAVGVGPDGRPCGTILEAAKLQGYMTGLVVTTRLTDATPAAFSSHVDHRWYEDLIAEHQLGTYPLGRVVDLMIGGGRTHFYGSQDTKYGDGGSRKDGRNLIDKAVEDGWQYVGDMEGFKRLQGGHNASLPLLALLADYDIPFDMDRDDAVHPSLEQEMMTAINALTDATKDSDRGFFLLVEGSRIDHAAHQNDPAAQAK... | 141 |
A0A1U8B419 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKTLAFLFLLSSGFWALAATADSYGLSYDYYSETCPQAETLIAETMKKIVKKDVTVPARMIRMHFHDCFVRGCDGSILLDSTPGNKAEKDAPPNNPSLKGFEVIDKLKAVLEHHCPGVVSCADILAYAARESVFLSGNGKVEQYKIRGGRKDGRISKDIDALNNLLPPTAEVDTLIQGYAAKGLSVEDLVTLSGGHTVGVSHCSSINGRQDNFKNTGRPDPTLDSHLASMLRGECRSSKGADPIVVMDRFTPLVLDNKYYVGLVQNKGLFTSDQTLLTNELTRKEVMENAYYPGVWEKKFVASMIKMGEIEVKTGNQGEV... | 14 |
P0AA89 | 2.7.7.65 | ACT_SITE 376; /note="Proton acceptor"; /evidence="ECO:0000255" | MEMYFKRMKDEWTGLVEQADPPIRAKAAEIAVAHAHYLSIEFYRIVRIDPHAEEFLSNEQVERQLKSAMERWIINVLSAQVDDVERLIQIQHTVAEVHARIGIPVEIVEMGFRVLKKILYPVIFSSDYSAAEKLQVYHFSINSIDIAMEVMTRAFTFSDSSASKEDENYRIFSLLENAEEEKERQIASILSWEIDIIYKILLDSDLGSSLPLSQADFGLWFNHKGRHYFSGIAEVGHISRLIQDFDGIFNQTMRNTRNLNNRSLRVKFLLQIRNTVSQIITLLRELFEEVSRHEVGMDVLTKLLNRRFLPTIFKREIAHA... | 120 |
P0CO06 | 2.3.1.48 | ACT_SITE 286; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q12341" | MAETLEEWISDSNQVLNLQMVRTPEDASLLQYEEQQNIDVFNPAFTYPIFGDNEKIFGYKGLDIKLHFASGSLRQYLDISYDAKLASSTTPPDEIEGALYKFIPPDYTKSEVEFQKRVAGDAETFKPLGEKIGSYAHPSAGRKGKGQGDSGMAAGKAIEDNEDVVEYEMYKATWSTPGFREYHRRMQIFVLLFIEGGSYVHEDEDAWEFIVLYERRTRPDSGIFTYHFVGYVSVYPFWCYPDRVRLRLSQFVILPPYQHQGHGSKLYNMLFRHMLDRSEVAELTIEDPAEAFEDLRDRNDLRFLVKEGIVKDPMLYVDVG... | 61 |
I1GQL7 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTRDRSSVVTMLLVPLGIMLALSCSAFAQLETGFYSATCPKVEEIVREETVKIISAAPSLAGPLLRLHFHDCFVRGCDASVLLDSTPGHLAERDAKPNKSLRGFGSVERVKAKLEAACPGVVSCADVLALMAREAVVLAKGPTWTVPLGRRDGVASSAAEASKELPPSFGDVPLLAKIFASKGLGVKDLAVLSGAHTLGTAHCPSYADRLYGRVVDASLDSEYAEKLKSRCKSVNDTATLSEMDPGSYKTFDTSYYRHVAKRRGLFRSDAALLDDDTTKGYVQRVAAAGNFDGTFFRDFGESMVKMGNVGVLTGVQGEIR... | 14 |
A5HXQ3 | 5.6.2.2 | ACT_SITE 121; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MLNEGKILPVDVSKEMKKCYIDYAMSVIAGRALPDVRDGLKPVHRRIIYSMQGLGLAPEKGYRKCARIVGDVLGKYHPHGDTAVYEALVRMAQNFSIRYTLVDGHGNFGSVDGDGAAAMRYTEAKMSKISMELIKDINKNTVDFIPNFDGEEEEPSVLPSRFPNLLVNGSSGIAVGMATNIPPHNLTEVIDGIIMLIENEDVNILDLMTKIKGPDFPTSGLIVGTRGIREAYETGRGKVIIRAKAEIEEEKGKNKIIVTEIPYQVNKARLIENMANLVKDKKINGISDLRDESDRDGMRIVIELKRDANPNIVLNQLYKH... | 222 |
Q0UCI9 | 6.5.1.1 | ACT_SITE 326; /note="N6-AMP-lysine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10135" | MAEDTEMPDAEAVRENTLMYGHDDELDEKFPTRPMNLHKSPPFHTLFTDLFDPLMETQKKGRQPPGPRRKAGPHGHSNLSPHEAKRNIIERFIASWRKTVGNDFYPAMRLIIPDKDRDRAMYGLKEKAIAKVLIKLTKISKDSDDAKQMLNWKLPGQLHKASASTAGDFAGRCYQVLSSRQLNTKLGDMSIAEVNNALDKLSQLGSEDEQVKIFQRFNRRMNAEEMTWLIRIILRQMKIGATEKTFLDIWHPDAETLFNISSNLRRVCWELYDPKVRLEGEDTGLSLMQCFQPQLAAFQDKGGSFEKIVARLQANSDDDS... | 254 |
A0A1U8ILP6 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKMRAGYSIFILLVSLTLIGIVDVCNAGKLSYKFYKRTCPRAEQIVKEIIQNRTQSNPSLGARLIRMQFHDCFVRGCDASVLLDTVNNSTAEKVAIPNSSLSGFDVIDDIKTAIERACPKVVSCADILALAARDAVSAPFSKPLWDVQLGRRDGMVSLATETNGNLPSPFANFTSLIQLFNRKGLDVNDLVVLSGAHTIGVAQCATFSSRLYNFTGKGDADPSLDPTYAEALRKQCPNPASPTITVEMDPTSSLSFDNHYYDILLQKKGLFVSDAALLTNRNSNKIVTRLQRSRSSFFPAFAKSVKKMGAIEVLTGNAGE... | 14 |
P14680 | 2.7.12.1 | ACT_SITE 496; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNSSNNNDSSSSNSNMNNSLSPTLVTHSDASMGSGRASPDNSHMGRGIWNPSYVNQGSQRSPQQQHQNHHQQQQQQQQQQQQNSQFCFVNPWNEEKVTNSQQNLVYPPQYDDLNSNESLDAYRRRKSSLVVPPARAPAPNPFQYDSYPAYTSSNTSLAGNSSGQYPSGYQQQQQQVYQQGAIHPSQFGSRFVPSLYDRQDFQRRQSLAATNYSSNFSSLNSNTNQGTNSIPVMSPYRRLSAYPPSTSPPLQPPFKQLRRDEVQGQKLSIPQMQLCNSKNDLQPVLNATPKFRRASLNSKTISPLVSVTKSLITTYSLCSP... | 107 |
A0A2R6XI76 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTRDWRFLLSMFLAASTLVVHVQCTYGVGGGLMVGFYDGTCPSAEALVKATVESAIASDKRNGAGLVRTFFHDCFVEGCDASVLIDSTPDNSAEKDGRPNLTLHGFEFIDMAKASIEAACPGVVSCADIVAIAARDSVHLLGGPYYEVKTGRRDGRVSLASGTSDIPNPIDDLATLTSSFAKKGLSQSQMVSLSGLHTIGKATCGAFTNRLYNFSSTASTDPTLDAEYAEQLKAACPPGSETGTTVVDMDVATPELVDNQYYVGLVAHKGLFTSDEVLYTSAETQPQVLRNAQSAYSWTSEVVRDLTAMGDVEVKTGSNG... | 14 |
A2WV32 | 2.4.1.12 | ACT_SITE 308; /evidence="ECO:0000255"; ACT_SITE 688; /evidence="ECO:0000255" | MMESGVPPCAACGDDAHAACRACSYALCKACLDEDAAEGRTTCARCGGEYGAPDPAHGQGAVVEEEVEESHEPVASGVRERVTMASQLSDHQDEGVHARTMSTHARTISSVSGVGSELNDESGKPIWKNRVESWKEKKKEKKASAKKAAAKAQAPPVEEQIMDEKDLTDAYEPLSRIIPISKNKLTPYRAVIIMRLVVLGLFFHYRITNPVYSAFGLWMTSVICEIWFGFSWILDQFPKWCPINRETYVDRLIARYGDGEDSGLAPVDFFVSTVDPLKEPPLITANTVLSILAVDYPVEKISCYVSDDGSAMLTFESLAE... | 70 |
Q8NB14 | 3.4.19.12 | ACT_SITE 454; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 857; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDLTTRLILEGQDPFQRQVGHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVAILDYIHNGLKLIMSCPSVLDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKGKLSITFCQQLVRTIGHFQCVSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFASISSTDASFEPSVALASLVQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKGLAAVQKFTILIDVTLLKIELVFNR... | 175 |
Q56UN5 | 2.7.11.1 | ACT_SITE 1186; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIEECNKIE... | 99 |
A0A3B5XVF0 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVIKLSAGAIAVSVCLSLAFFAGHGQPVLADGGGGKKHDVADTVKKEVAMSIKKNPRIGAALVRLLFHDCWVHGCDGSVLLDKAPDGGSTEKDATNNIGLEGFDLIDRIKGKLGESVSCADIVVLAARDATFILSRGNIAYDVTTGRKDGVRSSAAAADAVLPPSTFNFTQLKANFAGRNFTQTELVVLSGTHAVGVAHLSSFRDRLDNATATPISARYQRALAEHIEEQKGVQGTPDPTEPNNIRDMELAFRNASGHNASGVDTSRAARGVLDNSYYHANLQNKVLFRSDWELRNDTTGAAGRDMREFRDDAATWYLLF... | 14 |
Q0U8C3 | 3.2.2.27 | ACT_SITE 130; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166" | MSLKRKAGEAATDASKKPKANGSITAFFGAPKPAANSKAAAAAKFDREAWVAKLTEEQKDLLKLELETLHESWLPHLKDVLLTPQFLNLKRFLKQELKSGKTIYPPMKDVYSWSRHTPLDTVKVVITGQDPYHNPNQAHGLCFSIRPPTPAPPSLQNIYKALKIDYPDYKPPPNKSGLLTPWAERGVLLLNTCLTVRRNEANSHSGKGWELLTQKVIDTVVKVRTNGVAFLAWGTPAQNRTKGIPVDKHLILKSVHPSPLSASRGFFDCHHFTKCNQWLEQRYGKGGGIDWDLNVDPEKVTEEAAGEATEAAAKEVTGGA... | 173 |
P29951 | 5.3.1.8 | ACT_SITE 310; /evidence="ECO:0000250" | MQVPLLRLQCGVNSYDWGRVGPESAAAKYAAATAPSDFTIEADKPYAELWMGTHPSLPSKDVETQRTLLDMVQDNLALMSPEVSERYGGKLPFLFKVLSIRKALSIQAHPNKKLAEALHARDPRNYPDDNHKPEMTIAITPFEGLCGFRPLAEIVHFLKAVAPLRYLIGVQTATDFENAVRGFENTEDPEQTKKNKVALRTLFTSLMQSASENIEQAARELVAAAQSSPETFASLVNAPDTNPTNAAELASIIIRLNEQFPNDIGLFVFFFLNFVRLEPGEAMFLKADDIHAYISGDIIECMASSDNVVRAGFTPKFKDV... | 214 |
H3HD13 | 2.7.11.1 | ACT_SITE 469; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MNDGGDDGARRMSRVQAEWLIAGAYRIPAAVSDGDSAAPPTTSGPKLRALTRLPSRGLSSLLTSSNEFYLQQSGVQFYVDDIVRQLQDKRPDHPAQFIANYFSAVVKGSNVKGRPFEYVNGCLQNRAAFLAQLQRSYAKIDQNTIANAVAADRVIARLRVVAQQNTFNIPPMPEVELIAAKSSSFTEFCNLFYESPVLAGCILNLQLAFQKLAPVQKYCELTLRPMYTRPGSADSRMGARPTGANSFRLRSDENRRPNFGRGQPSPSAADVDMKDASPSSATSGRFQRPSPASATSSTFGSLDGPNSFFTGTSNGTYFSS... | 99 |
P57078 | 2.7.11.1 | ACT_SITE 143; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEGDGGTPWALALLRTFDAGEFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICREPVGLVMEYMETGSLEKLLASEPLPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACSHLIRLMQRCWQGDPRVRPTFQGNGLNGELIRQVLAALLPVTGRWRSPGEGFRLESEVIIRVTCP... | 99 |
Q8RF62 | 2.4.1.18 | ACT_SITE 302; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"; ACT_SITE 343; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685" | MILMSGQMEQYLFHRGEFRQAYEYFGAHPTRSSTIFRIWAPSAKSVAVVGDFNDWRAREEDYCHKLTNEGIWEVEIKKIKKGNLYKYQIETSWGEKILKSDPYAFYSELRPQTASIVNGKPKFRWADKRWLNNREIGYAKPINIYEVHLGSWKKKEDGTYYNYKEIAELLVEYMLEMNYTHIEIMPIIEYPFDGSWGYQGTGYYSVTSRYGTPDDFMYFVNYFHKNNLGVILDWVPGHFCKDSHGLYRFDGSACYEYEDPSLGENEWGSANFNVSRNEVRSFLLSNLYFWIKEFHIDGIRMDAVSNMLYYKDGLSENKHS... | 73 |
Q9WY52 | 2.7.1.11 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339" | MKKIAVLTSGGDAPGMNAAVRAVVRYGVRQGLEVIGVRRGYSGLIDGDFVKLEYKDVAGITEKGGTILRTSRCEEFKTEEGRELAAKQIKKHGIEGLVVIGGEGSLTGAHLLYEEHKIPVVGIPATIDNDIGLTDMCIGVDTCLNTVMDAVQKLKDTASSHERAFIVEVMGRHSGYIALMAGLVTGAEAIIVPEIPVDYSQLADRILEERRRGKINSIIIVAEGAASAYTVARHLEYRIGYETRITILGHVQRGGSPTAFDRRLALSMGVEAVDALLDGEVDVMIALQGNKFVRVPIMEALSTKKTIDKKLYEIAHMLS | 84 |
P9WI63 | 2.7.11.1 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVEAGTRDPLESALLDSRYLVQAKIASGGTSTVYRGLDVRLDRPVALKVMDSRYAGDEQFLTRFRLEARAVARLNNRALVAVYDQGKDGRHPFLVMELIEGGTLRELLIERGPMPPHAVVAVLRPVLGGLAAAHRAGLVHRDVKPENILISDDGDVKLADFGLVRAVAAASITSTGVILGTAAYLSPEQVRDGNADPRSDVYSVGVLVYELLTGHTPFTGDSALSIAYQRLDADVPRASAVIDGVPPQFDELVACATARNPADRYADAIAMGADLEAIAEELALPEFRVPAPRNSAQHRSAALYRSRITQQGQLGAKPVH... | 99 |
A0A8V0YCV8 | 2.7.10.1 | ACT_SITE 696; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MVSWRRRPGPGLARLWGLCCLVLGCWRGALGCPASCRCSSWRIWCSEPVPGITSFPVPQRSTEDDNVTEIYIANQRKLESINDNEVGFYVGLKNLTVVDSGLRFVSRQAFVKNINLQYINLSRNKLSSLSKKPFRHLGLSDLILVDNPFKCSCEIMWIKKFQETKFYTEAQDIYCVDDSNKRIALMDMKVPNCDLPSANLSNYNITVVEGKSITLYCDTTGGPPPNVSWVLTNLVSNHESDTSKNPASLTIKNVSSMDSGLWISCVAENIVGEVQTSAELTVFFAPNITFIESPTPDHHWCIPFTVKGNPKPTLQWFYEG... | 97 |
F6PPJ1 | 2.7.11.13 | ACT_SITE 364; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000554-1" | RDIVKMSIDAGSHQILAKVYYSGHAFSLHLEHTIQMEELFTMVRLNCNFPDAQVFTLKWMDDEGDPCTISSQLELSEALRLYRHNNETVLLFHIFLGIPVEPGLLCPGEHKLYRHGARRWYKLKRILRQIKKPKHPRIPIESGPILDSGDSQDSKQFHPRFCYNECNCILTMSPQIFKQNLKQLLLHIPPSFCLSNYRSYLVVTPYVLCKQTPIYTKYKQTSASSDQASPNAPGFGLKDFEMLKVIGRGSYAKVLLVKLKSTDKMYAMKVIKKELVTDEEDIDWVQTEKHVFETASNYPFLVGLHSCFQTPERLFFVIEY... | 100 |
Q5U1T3 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKVFMAVCMLAVAVRLAAAIVVPSAAPCALTVGFYNGKCGNVSVESVVYDTVKAFLDADKSKGAALVRLLFHDCFVNGCDGSILLDNSTTNPSPEKFAGANLGIAGLDVIDAVKAKLETACPGVVSCADIVVFAGRDASRYMSNGGVNFDVPAGRLDGIVSSSVDAQNTLPDSKADIGKLIANFAAKGFTPEELVILSGAHSIGKAHCSNFDDRLTAPDSEINADYRDNVLSKTCKSAPNPTLANNIRDIDAATLGDLASYVVPAVGGDYLDNSYYKNNKNNLVLFNSDWALVGSNATLQHVNEYAENGTLWNIDFAQAL... | 14 |
Q8H186 | 2.7.11.1 | ACT_SITE 197; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGSCLSSRVLNKSSSGLDDLHLSSCKSSSSATAHKTEGEILSSTTVKSFSFNELKLATRNFRSDSVVGEGGFGCVFRGWLDETTLTPTKSSSGLVIAVKRLNPDGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEQRLLVYEFMHKGSLENHLFANGNKDFKPLSWILRIKVALDAAKGLAFLHSDPVKVIYRDIKASNILLDSDFNAKLSDFGLARDGPMGEQSYVSTRVMGTFGYAAPEYVSTGHLNARSDVYSFGVVLLELLCGRQALDHNRPAKEQNLVDWARPYLTSRRKVLLIVDTRLNSQYKPEGAVRLA... | 99 |
A0A2I4EZ76 | 3.1.3.48 | ACT_SITE 30; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 32; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MGDNLHVPHEETKGIVEDTVDGRLDVYIWDMDETLILLKSLLNGMYAEAFNGLKDAQKGVEIGKMWEKHILDLCDSHFFYEQIENYNKPFLDALLQYDDGKDLSGYKFDQDGFGPPHDDDNKRKLAYRHRYIAQKYEKGLHNFFDQETMKLWDELYDVTDKYTDGWLSSARAFLEQCSSGKKDATSSVAPAVGVLDSPDSNYQQVNVLVTSGSLIPSLVKCLLFRLDGIITHGNVYSSWEVGKVQCFQWIKERFSCSNVRFCVIGDGWEECEAAQAMRWPFVKIDLRPGSSHRFPGLTLRTVGYYFSVVYGSPDAEDDKD | 149 |
B3S9A1 | 2.7.1.21 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1" | LILGPMFSGKTTELMRRVRRLQIGNQSCVIIKYANDNRYDKDGVATHDLQIAKAISSNDLFSIESQAESYGVIGIDEGQFFPDVVPFAEHMANKGKLVIVAALDGTFQRKGFGDFLNLIPLAEDVMKLSAVCMLCYSEGAFTKRLSSEQTVEVIGGTDKYMAVCRNCYKKPIKELHLQETPTKATNLGRKLILDEEVTASS | 88 |
Q9C5S1 | 3.1.3.48 | ACT_SITE 235; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MVGREDAMGNDEAPPGSKKMFWRSASWSASRTASQVPEGDEQSLNIPCAISSGPSRRCPAAPLTPRSHHNSKARACLPPLQPLAISRRSLDEWPKAGSDDVGEWPHPPTPSGNKTGERLKLDLSSTQQRVTDKSSGLAKREKIAFFDKECSKVADHIYVGGDAVAKDKSILKNNGITHILNCVGFICPEYFKSDFCYRSLWLQDSPSEDITSILYDVFDYFEDVREQSGRIFVHCCQGVSRSTSLVIAYLMWREGQSFDDAFQYVKSARGIADPNMGFACQLLQCQKRVHAFPLSPTSLLRMYKMSPHSPYDPLHLVPKL... | 149 |
A8IJ60 | 3.4.21.92 | ACT_SITE 144; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 169; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MVAAALLGGLQGACPLVAGKRSARRACVPKAQLHDSQRPKGWDRPWIQANSQPIVAPRTAEMQGDPFGLLLRQRIVFLGGEVEDFGADAIISQLLLLDSQDPTKDIKIFINSPGGSVTAGMGIYDAMMLCRADVNTYCFGLAASMGAFLLGAGKRGKRNSMPNSRIMIHQPLGGASGQAVDIEIQAKEIMYHKANLNRIMADYCQQPLSKIEEDTDRDRYMSPLEAKEYGLIDHIIGGEEAVFNVKGSLKKFPKIKEEFVTDKDDMVKRNIMDGDPFLSETPSWRFKSPQTEPYMPSQAPGSRWFRTRKVSKEDYKEMQE... | 179 |
P46549 | 2.7.11.1 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MAPAVLQKPGVIKDPSIAALFSNKDPEQRYQDLREIGHGSFGAVYFAYDKKNEQTVAIKKMNFSGKQAVEKWNDILKEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLVDPAQTFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQNDPPTLSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTKNMVLELDNFQYKKM... | 99 |
Q5A8X6 | 6.2.1.5 | ACT_SITE 276; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03222, ECO:0000256|PIRSR:PIRSR001553-1" | MYRQFTRGFSSSLPARNYASTIKNLKVTKDTKVIYQGFTGKQATFHAEQAIAYGTDVVGGINPRKAGTTHLDRPVFGTVAEAMKEAGASATGIFVPPPLAAAAIEEAIAAEIPLAVAITEGIPQKDMVRISQILKTQEKTRLVGPNCPGLIAPDQCKIGIMPSSIHQRGKVGVISKSGTLTYEAVAQTTAVGLGQSLVIGMGGDPFPGTNFIDALTLYLNDPETEGIIMIGEIGGSAEEEASEFLKQHNLTRPEGPKPVVGFIAGVSAPPGRRMGHAGAIVAGGKGDAKSKIAALESAGVVVEKSPARLGNSLLAEFKNK... | 247 |
A0A3Q2HAL6 | 3.1.1.4 | ACT_SITE 67; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 112; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MEVPLLCVLVVFAGVIPTQGGILDLNKMIRQVTGKTPFFSYWFYGCHCGLRGKGQPKDATDWCCHAHDCCYTHLKYHKCRRRWDRYHYTFSEGDVQCPEKGSWCEQQLCACDKELAFCLKSNLDTYQNHLRFYWRPRCKGQTPMC | 130 |
G5EBH0 | 3.1.4.11 | ACT_SITE 355; /evidence="ECO:0000250|UniProtKB:P10688, ECO:0000255|PROSITE-ProRule:PRU00270"; ACT_SITE 403; /evidence="ECO:0000250|UniProtKB:P10688, ECO:0000255|PROSITE-ProRule:PRU00270" | MAKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFL... | 153 |
Q9JYX2 | 1.1.1.49 | ACT_SITE 238; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MSTQTNFDLVLFGATGDLAMRKLLPCLYQAHVAGLLHPEGRILGVSRSELDTEGFLAKVETSSKIHVKENFSDEAWASFVERFAYLKVDVTQPDDFAALGDLVKARKETDNVVIYLSTAPKFFAQACENLAAIGLNADNVRVVLEKPLGTDLASSQQINTDVARYFKEGQIYRIDHYLGKESLQNLLALRFANVMFEPLWNNKYIESVQLTIAEQLGVEERGEFYDITGALRDMVQNHLMQMLCMTAMEAPASLDADAVRDEKVKVIKSLKPLTVESVNENVVRGQYTAARGMNGYLEEINVPQDSFTETYVAIKAEIEN... | 6 |
A0A0K9PRM4 | 3.1.1.11 | ACT_SITE 222; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAFPKKTITDEKIFCILVLSSSFFFFFFHSSVFVGAQTTFITRKDFAVDNDVNEFNEYSAVIVVSKDGRGDSLTVQGAVDLVPDLNTRRIKIFVSPGVYREKVVIPSTKPFISFIAHPNSTTVLSWNSKASDPSPTGDGIVGTYNSASVAVESDYFIASDITFENTSGDAPPGSVGLQAVALRVTGDKAVFYRCRFLGSQDTLFDHIGRHLFLQCYIRGSIDFIFGSARSLYEDCEIESTARSSGAIAASQRNGYDDICGFSFFNCRVRGSGKVYLGRAWGRFSRIIYAFCEMEGIVIPQGWNDWGDSTRRFTTLFAEFN... | 125 |
P75611 | 2.2.1.1 | ACT_SITE 397; /note="Proton donor"; /evidence="ECO:0000250" | MKNLFACQHLALSAIQHAKGGHVGMALGASPILYTLWTKHIQFNPNCPKWINRDRLVMSAGHGSMALYPILHFAGLITKQEMLHHKYGQVNTSSHPEYAPNNFIDASTGPLGQGLGMAVGMALTQRVLAAEFKALSPKLFDHFTYVVVGDGDLQEGVSYEVAHLAGVYQLNKLIVLHDSNRVQMDSVVRDVSLENLQTRFTNMGWNYLETSDAVADIDAAIKQAKKSDKPTFIEVHTTIAKNTTLEDQPAGHWFIPTDKDFARFNSNTKTNFTPFEYPQTVYDFFHKQVIARQAKPVQAYKELLEKLKDKPLYTKFINWT... | 51 |
Q9USS6 | 3.1.3.2 | ACT_SITE 35; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9NPH0"; ACT_SITE 330; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P15309" | MSQMSSASVKFPDSVPGVDYPKQLQLKYLQVIFRHGERAPVKERLGSAGIPKDWKLCNNARRFFAQIKGEKEWSVLGFERKVESPVDTSLAAPTSDNSPSGVCIHGELTDFGRVTTRTLGEYLRERYVKQLKFLPDELNNYADVYMRATPMVRALESLEHVFSGLYPESKRKMGLPVIFTRNWSDENLLPNENNCPRLVQLYEEFAERAAKLYDPLLAGRASEMMSQFMNGQPVRVVSSHPRLSGLLDTINAAIGSHVDFNPNLRDEQWLRDAETAVVEEWFGGYKVSKLMRQLGAGSLLNDLSMRMENFVVAEKNGSPY... | 145 |
Q84SL0 | 2.7.11.1 | ACT_SITE 199; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNCCVTPEGSGRGRKKQQQEQKQKQKEPKQQQQQQKKGKKPNPFSIEYNRSSAPSGHRLVVLREPTGRDIAARYELGGELGRGEFGVTYLCTERETGDAYACKSISKKKLRTAVDIEDVRREVDIMRHLPKHPNIVTLRDTYEDDNAVHLVMELCEGGELFDRIVARGHYTERAAALVTRTIVEVVQMCHKHGVMHRDLKPENFLFANKKETAALKAIDFGLSVFFTPGERFTEIVGSPYYMAPEVLKRNYGPEVDVWSAGVILYILLCGVPPFWAETEQGVAQAIIRSVIDFKRDPWPRVSDNAKDLVKGMLNPDPRR... | 99 |
A0BLG1 | 2.7.11.1 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MRKKRALNEFEFVEKKDNGKAQEELGKGAFGRVRLAHDKVTDTKVAIKTIPKKLLKENAQAENIKREIKLHRKLDHPHIVKLYHSLEDETNVYLVLEYVPMGNLFVYLKKRKTLEEQEAFVYFLQTALALDYLHKKGIIHRDLKPENILLDAQGNIKICDFGWSAELQPERRTFCGTLDYMCPEMLNSQNHDHRVDIWAMGILLFEMLHGHAPYNKNRQSQEVVIKAILNAATTKIPFNDKISNDAKDLIQALLKVNPLDRLSMEEIFNHKWIKVHARALQINIPEFVYEKGVNETVQSIQDISIDFGNLTQPSNNYQSQ... | 99 |
K3ZU40 | 4.1.1.17 | ACT_SITE 336; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MVGSSPMQAVLVAPGVKDRKVLAFERSGALKDKDAATGLVRAILAANPAQRSAFYVFDLAKVIDLFRAWRRALAGVRPCYAVKCNPDPALLGALAALGAGFDCASRAEIEAVLALGVHPRDIVYANPCKPEPHLEYAAEVGVNLTTYDSVEEVAKVKRCHPCCELLLRLKGPDGGKAKVDLGIKYGALADEVVPLLRAAQCAGLNVAGVSFHVGTGASCIDVYRGAIELSRAAFDAANALGMPPMRILDIGAFGDLPCVEVIGEPGRYFAETVFPLAVRVIGKRTRGEVREYWIDDGVYGSLNCILMDYYVPRPRPLATP... | 195 |
A0A2C9WPN3 | 3.1.1.11 | ACT_SITE 194; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKNLYLFFIGGMVLLLHCSSRGCKASDCQPNTISTITVDISGHGNFTSVQSAIDFVPEGNTQWIRIQISPGKYSEKVAIPVNKSCIFLDGAGRELTSIEWGDHEETHTSATFTSYPDNIVAKGIKFKNTYNLPDGLNKIDIMKEELIWKQAVAARILGDKCAFYECGFVGLQDTLWDEEGRHYFNSCYIEGSVDFIFGQGQSIYEGCEISVNIGRFAPGVTGYITAQRKQQPQDSNGFVFKNCNISGTGTVDLGRAWGPYSTVVFYNSTMSDVIAPEGWNAWNFVNHEANFTYVEEDNKGPGADTSKRVPWEKKLDPNEL... | 125 |
P77872 | 1.11.1.6 | ACT_SITE 56; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 129; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MVNKDVKQTTAFGAPVWDDNNVITAGPRGPVLLQSTWFLEKLAAFDRERIPERVVHAKGSGAYGTFTVTKDITKYTKAKIFSKVGKKTECFFRFSTVAGERGSADAVRDPRGFAMKYYTEEGNWDLVGNNTPVFFIRDAIKFPDFIHTQKRDPQTNLPNHDMVWDFWSNVPESLYQVTWVMSDRGIPKSFRHMDGFGSHTFSLINAKGERFWVKFHFHTMQGVKHLTNEEAAEVRKYDPDSNQRDLFNAIARGDFPKWKLSIQVMPEEDAKKYRFHPFDVTKIWYLQDYPLMEVGIVELNKNPENYFAEVEQAAFSPANV... | 13 |
A0A1U8FQY4 | 5.3.1.8 | ACT_SITE 312; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MSSMEGKGRVVKLTGCVKNYDWGRAGKESRVARLYACNSGDTVDLEKPYAEFWMGTHDSGPSYVVEGAAGVSENGLGNSGGRERNKLTLKEWIENNPIVLGEKVVNKWGTNLPFLFKVLSVAKALSIQAHPDKDLASRLHSELPDVYKDDNHKPEMALALTEFEALCGFISLEELKLIVQTVPEIVELVGTARAEQVLELNEDGGKEKGKLVLKSAFTELMSASKDAVAEVIAKLISRLNVKNQARELTEKEQVVLRLEKQYPADVGVLAAFLLNYVKLNPCEALYLGANEPHAYIYGDCVECMATSDNVVRAGLTPKHR... | 214 |
A0A804ISM2 | 2.3.2.26 | ACT_SITE 1858; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METRSRKRAEASSSAPSSQTPPAAPRPAKRPRIALSSQAPPALSTRSRRSQNPPPSPPSSSSSAVANAVMDSSGGDFIGRRRRTSGKSRQPSGDRDRDASDKGKEAGASRARERDRDAERILGLSFDGGGADDDNDGDGGLGILHQNLTSASSALQGLLRKLGAGFDDLLPSSALTASSSLQQSGRLKKILSGLRADGEEGKQFEALNQLCEMLSIGTEDSLLSMSVDSFVPVLVGLLNHESNPDIMLLAARALTYLCDVLPSSCSAVVRYGAIPCFCARLLTIEYMDLAEQSLQALKKISQEHPTACLRAGALMAVLSY... | 65 |
Q8P8S0 | 3.5.4.33 | ACT_SITE 70; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MSVSPDHHAQDAHLQIDQQWMTHALRLAERAERDYDEIPVGAVLVDPTGALLGEGWNFNIASHDPSAHAEIMAMREGGRRLANHRLIGCTLYVTLEPCAMCAMAMIHARIARVVFAASDPKTGACGSVFDLLADPRHNHRVQVSGGVLAAEAGLRLTNYFRAKRGKPPLVP | 186 |
Q8W413 | 3.2.1.26 | ACT_SITE 64; /evidence="ECO:0000255|PROSITE-ProRule:PRU10067" | MAISNVISVLLLLLVLINLSNQNIKGIDAFHQIYEELQSESVESVNHLHRPSFHFQPPKHWINDPNGPVYYKGLYHLFYQYNTKGAVWGNIIWAHSVSKDLVNWEALEPALSPSKWFDIGGTWSGSITIVPGKGPIILYTGVNQNETQLQNYAIPEDPSDPYLRKWIKPDDNPIAIPDYTMNGSAFRDPTTAWFSKDGHWRTVVGSKRKRRGIAYIYRSRDFKHWVKAKHPVHSKQSTGMWECPDFFPVSLTDFRNGLDLDYVGPNTKHVLKVSLDITRYEYYTLGKYDLKKDRYIPDGNTPDGWEGLRFDYGNFYASKT... | 164 |
Q09298 | 2.7.11.1 | ACT_SITE 338; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSMKRFGKAAYRIANELVAKGGRLPIFQRFLPRIFPATYNLGVHVVLKKAPFPRQNALRIARLVTRHGRVFRPFSSVIIERHRFQNQNDWRRKFQPIRKELPRNVDLVERIRQIFGNSLRYNEDLKSTEWPNRIDSYEFGEFLGQGCNAAVYSARLANSDAESSGNTHYGAGFNEVTNILAEIPPVSKVAQKKFPLAIKLMFNFEHDRDGDAHLLKSMGNELAPYPNAAKLLNGQMGTFRPLPAKHPNVVRIQTAFIDSLKVLPDAIERYPDALHTARWYESIASEPKTMYVVMRRYRQTLHEYVWTRHRNYWTGRVIIA... | 99 |
A0A7M7N9V9 | 2.7.10.2 | ACT_SITE 995; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MTQKVSIRHMVNMLRLPSIRSSRESPGLPNGMEPDIVEVRTYMCGNLVLPWRERLTVEQVCIKAAKLCGIPRLTSNLFALYDKTNKKWLCPKAQVFSRRQRKSEQLEYRVRFHTATMCPSGDAQGFMLLEENVVNYMFCQYRESFLNDEFMGLSTEESLGLMVLDFMQHVKEDGTSLTNLNGRLRFGRFLPKSLNEGLSWWDKRKLRRKVRTALTDFRDDPRETFAFRVMFLVSLSEEMKQEWGTEQFTMANGDIYEVSGVKGVTKKKLTYGDEAVQDSFPFQDIIDITIYPSTAERAHTLLQINRRSTPPLILEMESRD... | 98 |
A0A3B3I699 | 2.7.10.1 | ACT_SITE 777; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MAPQRVPWIYMFLALVLLLHALSPSGALRNYPENEVTLLDSMSALADLGWTAYPNEGWEEISVMDERNTPMRTYQVCNVMEANQNNWLRTRHISREGAQRIYIEIKFTLRDCNSLPGVPGTCKETFNMYYYESNNVNLWFIKESQYVKIDTIAADESFTQVDVGDRVMKLNTEVRDISNLSKKGFYLAFQDLGACIALVSVRVFYKKCPLTVLNLAQFPDTITGGDTALVEVHGMCVNASEEFEPPKMYCSADGGWLVPIGRCVCKPGFEENKDVCQPCRPGTYKASATDAFCTKCPPHSSSPQEQADECICEKGFYRAE... | 97 |
Q9HZM6 | 3.1.3.48 | ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1"; ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617867-1" | MRVLFVCLGNICRSPTAEGVFRRKVEEAGLASRIHVDSAGTAGWHVGKAPDQRTRLAAQRRGYDLSALRGRQVGIEDFSRHDLILAMDLSNLADLETLRAGRGAAELDLFLRRYGSERDEVPDPYYGGEEGFEQVLDLIEHACDRLLIEAKGRL | 149 |
A0A2K2DU51 | 2.1.1.37 | ACT_SITE 522; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MPCGKRRRKAAGKPASRKRAAKRKPKEEMKLPEAVADAQQAVAAEAEGVMEVDDAGSAINDDDMCAEEMEMLEQEEAAAALEADEEAKGGGEESAETAGARKRVARPSTERKVDASEDHFVGEPVPDHEARQRWPERYRTKDSDSLVGRSAGEEDISARCHYRSACVDDAIFHLDDDVYVKAGPDEENYIGRIAEFFEGIDRGSYFTCRWFFRTADTVISRKLLMVHDHKHDHKRVFLSEEKNDNMIESIISKINIIYVDPNMTPKGKAQVISTCDFYYDMSYSVDYSTFANMPSENDGASGSEATSNISCDDDNSSKEN... | 47 |
Q5BG51 | 3.2.1.21 | ACT_SITE 99; /evidence="ECO:0000250" | MTVLAPWALWEKTKDVMVLEQQYQSMCTWIAAIPENMKRHRHLCDPVVLQFAVAVRESNPWAVMTAYHKINGVHCSEDPRLIRDIPRSEWKYDGLVLCDWWGIYSTSELINAGMDLEMPGPTDWRCKILAWATRSRKVSIETIDSSVRRVLKLVNRVLAAQSEPVKDSDTEKNRALLRETTAVPVVLLKKNEANVLPLVKDSKTRYALIGDHWKNPAVAGDDSSEVTPYYVSTPYSAFVEAVGEDSFICAMGCYSHKFAPLLYSTITQPGSDAHGMLLEFFNKDPNGSSDAELLYTTTTEKTDLKFADSLPPDTVPEYTS... | 161 |
A0A2C9WCH7 | 3.1.1.11 | ACT_SITE 25; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPLDTVYLHRGKQYLKDCYVEGSVDFIFGNSTALFEHCHIHCKADGYVTAQSRKTAEDSTAYVFLRCVITGNGGNSYAYLGRPWGPFGRVLFAYTYMDQCINHAGWHNWDKTENEGTACFYEYRCYGPGYDKSKRVAWCKELPDEQAEEFLRHAFIDPNPESPWLAQKLAHKTPVSA | 125 |
P47648 | 1.8.4.11 | ACT_SITE 10; /evidence="ECO:0000250" | MKEIYFGGGCFWGIEKYFQLIKGVKKTSVGYLNSRIRNPSYEQVCSGYTNAVEAVKVEYEEKEISLSELIEALFEVIDPTIRNRQGNDIGTQYRTGIYWTDSSDEKIINDKFLKLQKNYSKPIVTENKKVENYYLAEEYHQDYLKKNPNGYCHIKFD | 39 |
Q9XTW2 | 2.7.11.1 | ACT_SITE 366; /evidence="ECO:0000250|UniProtKB:Q8IXL6" | MRCNIKRLFTLAIGVFAATLVIISFSKDNYEREWKQGPQSNEARAVGHQSPDLFPVGQNSLPHQPIPPSLGEKDLSDPFNFLFSSNKITLRKLYDLTKNVDFDQLRQNECKKNITLSKFWEKSEQRNVPEDDNWERFYSNIGSCSVYSDDQMIDNLLHDLNTSPIKHVHIMDGGTQVKFVFTFKNDKQAVFKPMRFGRDYESDPNHFYFSDFERHHAEIATFHLDRVLGFRRAIPTVGRVLNMTTELFEKAEKKLKKTFFFSPAKNFCFVSRCDYYCDTTHAICGLPDMKEGSVQVFLPDESAVPRKHNRSPYRRTYSKK... | 99 |
A0A804JW41 | 3.1.1.11 | ACT_SITE 385; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTPSLLYPLRSNTGIMASSRPTFASLLLLLLLLLLLTSAQGSSLNTTAWHPECETPKAPRRVSSSASSFVPSADFVSTLQSTLEEIKKVMSLVSTFSGVLGGDLRLSSAVDDCLDLLDLSSDELTWTLSASQRTTASASASGAGNRRSDLRSWMSAALGNQDTCKEGLDGTGGLVETLVAGGLDMVTSLVSDGLREIAAGGGTGGKGGSRRLMGFPEWVSAADRRLLQAQPTTVADAVVAQDGSGNYTTVEAAVAAAPTEGARRYVIHVKKGVYKENVEVKKKKWNLMLVGDGMGQTVISGTRSYVDGWTTYRSATFAVA... | 125 |
E9AFZ6 | 2.1.1.33 | ACT_SITE 142; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MASEEQPRWTRLPIRTRPHRNPLAENDDEHPECPAQFERRFSEFYPGMVNPVVEFVDVGCAFGGMLFSLAAVFPATCMMGLEIRPKVVSFAQEKALALRQENAASLTQHYRNVWFEQMNVMKFGSNCFTKGQLSRLFFCYPDPHWKRKNIRRRIISPGLVQEYAYWLRHGGLVYTVSDVAELEEWMVQCLDDSPLFRRLAEAELCTPEHKQVLEIVTGASEDAQRTARKGLQKHFAVHMRI | 45 |
Q8A8R5 | 2.7.1.11 | ACT_SITE 130; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339" | MDNKYIGILTSGGDASGMNAAIRAVTRAAIFNGFKVKGIYRGYEGLIAGEVKELTTEDVSSIIQRGGTILKTARSETFTTPEGRKKAYKVIQKENINALIIIGGDGSLTGARIFAEEYDVTCIGLPGTIDNDLYGTDFTIGYDTALNTIVECVDKIRDTATSHDRIFFVEVMGRDAGFLAQNSAIASGAEAAIIPEDRTDVDQLETFIGRGFRKTKNSSIVIVTESPENKNGGAIYYADRVKKEYPGYDVRVSILGHLQRGGAPSANDRILASRLGEAAIQALMEGQRNVMIGIRNNEIVYVPFVQAIKKDKPIDKSLIR... | 84 |
A0A9R1V7X4 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVNNKTVAFVVAIGFIFLNLSGHCYGALQFGFYNGKCRGSDVEDIVRKTVLSKFLVDRTITPALLRMQFHDCFVNGCDASILLDGTNSEKTAPPNLSVRGYDVIDAVKTAVERVCPDVVSCADIIVMATRDAVSLSGGGRYNVQTGRRDGRVSLAKDAQILPSPSSSVSSAIQAFATKGLTATDMIYLLGGHTIGIAHCSFFQDRLYNFENSGKPDPTMDLALLTSLRRTCPRNATVDGKANLDQNSFSSAVVDKSFYTQIMLRRGVLQIDQELAVDGLSKSTVAAIAGSSDFTTKFGQAMVKLGGTHVLTGTQGEIRKS... | 14 |
Q9M1I6 | 3.1.1.3 | ACT_SITE 266; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 423; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MDISNEAGVDAFSIIGPTTIIGRTIAVRILFCNSVSIFRHKVFRILKFFLRGGRVLLSPFVSLLHPRNPQGILVMVTTMAFLLNRYTSLKAKAEMAYRRKFWRNMMRAALTYEEWSHAAKMLDKETPKVNETDLFDVELVSNKLDELKHRRHEGSLRDIIFCMRADLVRNLGNMCNPELHKGRLHVPRLIKEYIDEVSTQLRMVCDMDTEELSLEEKLSFMHETRHAYGRTALLLSGGASLGAFHLGVVKTLVEHKLLPRIIAGSSVGSVMCAVVGTRSWPELQSFFEGSWHALQFFDQMGGIFTTVKRVMTQGAVHEIR... | 128 |
A0A061EPT7 | 1.11.1.7 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQCLSSKMQQNLKRQKLRKRSKREREREREMKNSLVFSLISLIGLSGFVGVLCQGGALCNNFYETSCPLAEHIVQSITWTYVASNFTLPAKFLRMHFHDCFVRGCDGSVLLDSTANNSAEKEAIPNQSLAGFDVIDEIKSKLEETCPGVVSCADILALVARDSVSFQFGKPLWEVPTGRRDGTISRASEALANIPSPFFNFTTLKQSFANKGLTVQDLVVLSGGHTIGVGHCNFFSNRLYNFTGKGDADPSLNSTYADFLKTKCQSLSDNTTIVEMDPGSSLSFDNNYFTILKQNEGLFQSDAALLTDQGSSNIVDEMLN... | 14 |
Q0D4B2 | 2.7.11.1 | ACT_SITE 210; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQKTSMNPVTDPVAAATGRVAIRQLPIKTQPNSQSLTPFLQLPPKPPPNLLFSSPLASVELRHRARARRRRRPSHPRRAPAMRMGKYEMGRALGEGHFGKVKLARHADTGAAFAIKILDRQRILAMKIDEQIKREIATLKLLKHPNVVRLHEVSASKTKIYMVLEYVNGGELFDKIALKGKLSEKEGRKLFQQLMDAVSYCHEKGVYHRDLKPENVLVDAKGNIKVSDFGLSALPQNQRKDGLLHTTCGSPNYIAPEVLLNRGYDGSLSDIWSCGVILYVMLTGNLPFDDQNTVVLYQKILKGDARIPKWLSPGAQDILR... | 99 |
A0A9R0JJ74 | 3.1.1.11 | ACT_SITE 243; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAPRKHHILPLLSLFFLSRISWSDATPQKDYDKWLTWNVHNHHLRRLAAKPPPNAAAAGLSGSTPTTKALDVRLEKAEVNKERFIINQNGTGDYKTISEAIDNIPIHNTKRFILQIMPGVYREKIHIPKIKPFISFIGDPDNPPTITGNDTASSMSQGGGAALSTFQSATVAVDADYFIASNIIFENTAPHEVGTVGEQAVALRISGNKASFYESSFYGSQDTLYDHKGLHYFRNCFIQGSVDFIFGYGRSFYENCTLNSIAKKVASVTAQKRNEKSMSSGFSFKDCKVTGSGTVYLGRAWGDYSRVVYSFSFLDKLVLP... | 125 |
H2LW37 | 2.7.11.1 | ACT_SITE 312; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1"; ACT_SITE 329; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR038147-1" | MEEVTCVPGQFDDAEVDRDQSEPSLLPSLINDVAAQRVDSDEEEDEVDDDYDDEDDEEDWAYHSAANLTSRLNRSGLNCQANRQNPSNKMISSSTPSDKALRKYEHKINLDKLNYADSVINKVTAMQRQKEADTYRVKDKSDRATVEQVLDPRTRMILFKMLSRGIISEINGCISTGKEANVYHAITASGESRAIKIYKTSILLFKDRDKYVSGEFRFRHGYCKGNPRKMVRTWAEKEMRNLIRLQMAGIPSPEPLLLRSHVLLMGFIGKDNMPAPLLKNAALSESKARELYLQVVQNVRKMFQDARLVHADLSEFNMLY... | 99 |
M5XGZ6 | 2.7.1.11 | ACT_SITE 277; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MESAISSPLSTSSHLLPSPSRSSLGSRSQSFPSLQNLRHPSFKSRCFLGVPFRSRQTQPIRCQSSNQQPAKDDGFVIEDVPHLTDFLSNLPSYPNPLKQSQAYAVVKQTFVSTDDVVAQKVVVQKDDPRGVHFRRAGPREKVYFKSDEVRACIVTCGGLCPGINTVIREIVCGLNYMYGVEDILGIEGGYRGFYSKNTLRLTPKVVNDIHKRGGTFLRTSRGGHDTNKIVDNIQDRGINQVYIIGGDGTQKGAALIYKEVEKRGLQVAVAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVESVENGVGIVKLM... | 84 |
Q3SEA7 | 4.2.1.11 | ACT_SITE 223; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 359; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MKIKGGFSSIKNVIAREILDSRGNPTVEADVITSKGVFRSAVPSGASTGIYEALELRDGDKSRYLGKGVAKAVANVNEIIRPALVGKNVTEQTKLDKSIVEQLDGSKNKYGWSKSKLGANAILAVSLSLARAGAAEQNVPLYQYLAQLAGKRTDKFVTPVPSLNVINGGKHAGNKLAMQEFMILPTGAKSFKDAIQIGCEVYHSLKSVIKSKYGLDATNVGDEGGFAPSIQDPNEALQLLEDAIKKAGHTGKVDIGMDVAASEFFEKNTYDLDFKNAKNDGSKKLTAQQLTELYLKFVSSHPIVSIEDPFDQDDWEGYTQ... | 200 |
Q0CT11 | 3.4.19.12 | ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 419; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MGSLFRSFRRDAGATAPSVGATPAKKEPPPPPMTPLEKMLQDMGAIREDGSDKFFGMENYGNTCYCNSILQCLYYSVPFREAVINYPTRTPIESLTAALAETLRYPNPNAHLEAEAQAEKQKAANAQRPGAPPNQPQKPEDKDSPEYKKKMALQTFPLLETKNNAPSYGMSESLFTSLKDLFESVVGSQSRIGIVRPQHFLDVLRREHEMFRTAMHQDAHEFLNLLLNEVVANVEAEALKQPSLERSLPPAESSESVEHSGSSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEVFLDLSVDLEQHSSVTSCLRK... | 175 |
Q9SND6 | 2.7.11.25 | ACT_SITE 131; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEWVRGETIGFGTFSTVSTATKSRNSGDFPALIAVKSTDAYGAASLSNEKSVLDSLGDCPEIIRCYGEDSTVENGEEMHNLLLEYASRGSLASYMKKLGGEGLPESTVRRHTGSVLRGLRHIHAKGFAHCDIKLANILLFNDGSVKIADFGLAMRVDGDLTALRKSVEIRGTPLYMAPECVNDNEYGSAADVWALGCAVVEMFSGKTAWSVKEGSHFMSLLIRIGVGDELPKIPEMLSEEGKDFLSKCFVKDPAKRWTAEMLLNHSFVTIDLEDDHRENFVVKVKDEDKVLMSPKCPFEFDDWDSFTLDSNPSFDSPVER... | 105 |
Q9YDP3 | 2.1.1.37 | ACT_SITE 93; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018" | MSRYSTISLFSGAGGLDLGFVQSGRFRIVFANEILLPAAVTYSRNLGLRLEVCGDEPRVEAQPGTIMACDVAKLDFTGLSGVDADVIIGGPPCQDFSIVRGPDWDRRGINVKRGRLYAHFVRALASLQPKAFVFENVPGLVSANRGLAYKVILEDFARLSIRWDEIKRIVSSNGNGGKVEGYEIVFTGIVDFSKLGVPQKRERLVIIGLRKDLAGGGFETISRLRARIDHVLSGKRWLLHRYPLTPIEVFEGQPLDRLGDKYKEVMLKWEGVWDEVGTERAFEWKRRVWDRLTFDIISDYLSFNGIKHADKQELEEALMQ... | 47 |
M4DTL4 | 2.1.1.37 | ACT_SITE 384; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MKRPEPSTDLSFTGEPISAEEAIAKWPSRYRSSKARVSATVGTPKDGEENLEQAKRHYSQALVDGTLFNLGDDVYVKAEDGNPNYIAKIVEFFEAIDGEPYFRARWFYRPEDTVIKTLASEVQEKRVFLSNVEDDNPLNCIVSRVNIVKVPAKIVSGAEERVIPPCDFYYDMKYELAHLTFSTAADDGDASSTISSESDSNCIQIPQQKEKFLLDLYSGCGAMSTGLCMGASLSGVKLIKVRNEAAEDFLKLLIEWRKLCQKFGLISTTEVIESDGDSEDEEEDGDENDDADGDSNGSDIPPEEFEVDKFLDICFGNPNG... | 47 |
Q59WD3 | 1.11.1.24 | ACT_SITE 43; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P40581" | MGNELLSTARIYTFKIPDAYNNVIDFDQFKNKVILIVNVASLCGFTPQYKELQLLYEKYHERGLEILGFPCNQFGNQEPLQEEEIVESCRRNFGVSFPIMKKTKVNIDCDGHESELYKYLKSEKPGEVGFKGVRWNFEKFIVNRKGEVVARFNSLITPLQLEGFIEQLLSE | 12 |
P48609 | 2.7.11.22 | ACT_SITE 126; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYFTDSSSSGH | 102 |
A0A9R1VRX0 | 3.1.1.11 | ACT_SITE 163; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAKVIKVAKDGTGNFWNLQDAIDSIPLENKARTYITLSPGTYLQPIHIPKRKNLITITGVNPELTIITWYNCATKIEHHKPASLIGTGTFGCGSAIIEGDDFIAENVTFENNAREGSHQAVAVRVSADRCAFYNCRFLGFQDTLYLHMGKHYFKDCYIEGSVDFIFGNSTTLFEHCQIHCKAAGYVTAHSRTSSQETTGFVFLRCVITGTGGMHCSYLGRPWRPFSRVLFAFTYIDSCIKNEGWHNWGNHENEKTACFYEYKCMGPGSWADKRVWWGKQLSDREVEPFLNHTFIDPDRHKPWLWTKFGHRVPYSA | 125 |
Q9WZR0 | 6.3.4.2 | ACT_SITE 369; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 499; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 501; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MKKYVIVTGGVLSGIGKGIFSASLARLMKEHGVDVNVLKIDPYLNVDAGTMNPNQHGEVFVTEDGYEADLDLGHYERFLGRDMTRQNNMTAGQVYLRVIEKERQGKYLGNTVQIVPHLTEEIKDRIRALEAELLVVEIGGTVGDIEGEVFLEAVRELQMEEGKENFLFAHVTYVPYLRTTNEFKTKPTQQSVQLLRRIGITPDMVIVRSEFPLDVPSMNKVALFSGVPRDFVINLPDTKNVYEVPEILRDMGLHEKIASKLNVELKKSTFNWSYPKAFKPYRIALVGKYLGTDDAYKSIIESVFLTGIEKPTVVDSQMLE... | 252 |
A0A3B3H694 | 2.1.1.37 | ACT_SITE 640; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MPSNSPAAGEPPQTLENDASNDVSEDGADQDSPEEGTPASPHNKRRVGRPGRKRKQLLPEMATSDPCANAPPTPPEEPEPSPSPRKRRGRRRLEQTEKNREEPDDRNCDSPREGETGRLRRRPVPRVTFQAGDPYYISRRQKEEWLSRWKMEAERRAYREAEISMMDDLSEADFQKEEEPSSPAPPPSQQHTDPASPTVAVTPEPVARGDQATPSEIEYQDGRGFGIGTLVFGKLRGFSWWPGRIVSWWMSGRSRAADGTRWVMWFGDGKFSVVCVEKLMPLSSFSSAFHQPTYNKQSMYRKAIFEALQVASVRAGRPVP... | 47 |
O74536 | 2.7.11.1 | ACT_SITE 156; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQPQEVDLMENSTMRNGARVLPPEAISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHIIKLYDVITTPTDIVMVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQGSYADSRIVSKLGEAMGFSE... | 99 |
A0A6I8N5K6 | 3.5.1.98 | ACT_SITE 739; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MHRPSLDGSEVSLGTRRHGPPGPAYETLRGTPPGPQAAPMDLRVGQRPPPPAEPPAVEPSTPEPALLALQHTQRLHHQLFLASLQPRRPEHIRLSLETPGPEVPAGQQEQELCHLLHKDKSKRSAVASVAVKQKLAEVILKKKQAALERTGHANGPGVPGPGIPYRTLEALESEGGSPSMLSGILPPVPSLPSDPPEHFPLRKTVSEPILKLRYKPKKALERRKNPLQRKESAPPSLRRRPTEPLGGESARQAQWGAGTPRGKSEASGRTDPCPVQSRFPPLPPTDSSPSSSSTPVSGCSSPNDSEHGPCPAPGHEVDGD... | 184 |
A0A1U8B1Z2 | 3.1.1.11 | ACT_SITE 385; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSLTIFFLLLFSFPSFHALSNSTFSPQDHQTTIRDMIQQVCVDMADPETCFSNFRAEYELMDRHSPAAVLGAAIKASMNEAQKAMEVVNKFTVLSMNPREQMAVEDCKELLDFSVSELQWSLAQMDKTRSSKVKDVHSESNLHAWLSAALSNQDTCIEGFEGTNGRILNYIKGSINQVTQLIYNVLTMYHKMHSLPLKPPFYDPQVTGSLDFPTWMADVDPDGDFLAAGPQGIKVNAIVAQDGSGQFRSIMEAVNEAPDYSWRRYVIYVKKGIYKENVEVKKKKTNIMFVGDGIGVTVVTGNRNFGQGWTTFRTPTVAVT... | 125 |
W5MWQ1 | 2.7.10.2 | ACT_SITE 692; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | MGFGKDLRYSHEALLKLQDWELKLLETVKKFMTLRVKSDKEYASLLLNISQQVDKYENASQVDYISNVSKVILSAFAQHVHVLRMLGTPISEIMAHGYTYIILCCLRDAQELGRSSNFGLHLRVLQVTFKKTTLYTQLHKYNLTEPQDSSQLSVNTDKKKQCITMRKEPEKARERYDKVTMKLHNLHNQYVLAVRGAQLHQEHYHDTTLPLLLDSLQKMQEEMIKALKGILEEYSEITSLLSDEIVKVHKEIYTSIEQIDPASEYEHFIEVHRSPEMKQPCVEFDVSLLEETENLQANEILWNNLTADSLQAVLKSTSEE... | 98 |
Q10LQ2 | 2.7.11.1 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVEQKGNILMKRYEIGKLLGQGSFAKVYHGRNIKNSQSVAIKVIDKEKILKCELMDQIRREISVMNLVRHPCIVQLYEVMATKTKIYFILEYVKGGELFNKVRRGRLKEEVARKYFQQLISAIDFCHSRGVYHRDLKPENLLLDENRNLKISDFGLSALAECKRQDGLLHTTCGTPAYVAPEVINRKGYDGAKADVWACGVILYVLLAGYLPFQDKNVINMYKKICKAEFKWPSWFSSDIRKLLRRILDPNPATRISVSEIMEDPWFRVGLNSDLLNKTIPTDKVDKVVHVDMDSTFGNLSNNINEGKQEAENLTSLNAF... | 99 |
Q8ZJL6 | 2.7.1.11 | ACT_SITE 129; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339" | MVKKIGVLTSGGDAPGMNAAIRGVVRAALSAGLDVFGIEDGYLGLYENRMKKLDRYSVSDMINRGGTFLGSARFPEFRDPEVRKVALKNMHERGIDGLVVIGGDGSYAGADLLTKEGGIHCVGLPGTIDNDVAGTDYTIGFFTALETVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFIAIPEVEFKRDDLVAEIKAGIAKGKKHAIVAITEKLDDIDSLAKYIEKETGRETRGTVLGHIQRGGAPVAYDRILASRMGAYAVDLLLQDHDYKKGGFCVGVQNEKMVHELISVCIAPENKKSKFKEDWY... | 84 |
Q7UG96 | 3.1.3.3 | ACT_SITE 277; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 279; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MPDRRDTTRRICSRPNRQRRAGSQRHHCRLDRFIRCRRSPFTLSQRLIVPVTTNAPKPTPNAVVNDSILPSTLGNSPIAPSPPTIVLLRFTGDDCPGLTASISERLHRFNCRVIDVNQAVIHRSLLLGMLVQIPGSEDPERLIRKMRRKSRKLGLKCKAKIVCDPDYDAWVDRQGKSRFILTLLSRSVTAEQFAAVSRLVSDQGLNIDVITRLSGRPKREPGDELTRACVEFSLRGDPTDVNALKASLLELSNRLNLDLAWQRDDAFRRNRRIVALDMDSTLLQAEVIDELAKEAGAGEKVSAITEAAMRGEIDFDESLR... | 147 |
A0A3B3HI82 | 2.7.11.1 | ACT_SITE 172; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50"; ACT_SITE 538; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000606-50" | MSGDASDSSDDSDGKSHEETSTVKHQITNANLTGHTERVGMENFELLKVLGTGAYGKVFLVRKNSGHDAGQLYAMKVLKKAAIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTQSKLHLILDYVSGGEMFTHLYQRDHFSEDAVRVYIGEIILALEHLHKLGIVYRDIKLENILLDSEGHVVLTDFGLSKEFLEEEKERTYSFCGTIEYMAPEIIRGKAGHGKSVDWWSLGILMFELLTGASPFTLEGERNSQSEVSKRILRCDPPFPSMIRSVAQDLLKKLLVKDPHKRLGSGPRGAEDIKAHPFFKGLNWEDL... | 99 |
F0Z6W5 | 3.5.1.98 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MEYKTILNNTSKTKVCYFFDQDVGNYFYGPYHPMKPHRLCLTNNLVLNYGLHKKMHLYKARRADSEDFLRFHSDDYVDFLERVSPDNLSEWKDLSRFHIGEDCPVFPGLYDYCSIYTGGSIEGALKLNHRMYDIAINWSGGLHHARKDEASGFCYVNDIVLGILELLKFHPRVLYIDIDVHHGDGVQEAFYLTDRVMTVSFHKFGGDFFPGTGDIDEIGMHAGKQYSVNVPLHDGIDDRSYLSIFKPVIQGVMDYYRPSAIVLQCGADSLRFDRLGCFNLTINGHAECVRFVKSFNVPTMVLGGGGYTVRNVARCWTYET... | 184 |
A7RSQ4 | 3.2.1.52 | ACT_SITE 537; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MRVLYLYLVVAFCGYNSVYCQSVSQSTLDYIAANLGIRYDVLDNFQDSWRSYKVQLTLSNAGSQAIANGDWSIYLCHIRVIEPVHTKHNPDGYVLPGYGLKVTHVNGCQHRIQPTADFKPLLPGDSRPVLFNAENWAVAKTDVMPNFYVAAEGLQARTITSTSGESLDFVGPFDNKFKWKRFDPDKYNPFTPEERFAKNNVTDLKRPGLLVLPSPSEVTGYDPHQQVNLLTGDWEVIAGDELKNEAAFLAEKLGIRAVSFSQFRQIKLQLGDVAVGNLGNPSKEAYSLEVDAAAERILITGVTPLAVFWGVQSLLSLGHS... | 170 |
A0A1B6PJT3 | 2.3.2.26 | ACT_SITE 1854; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METRSRKRAEASSSSATSSSSRSSKRSRPNPNPNPNPNPPAASSSPAPNPVPLPPRTRRSAAVNPLPAMDSSGDNNSNPNPPPRRRGRPSNADKGKEQQQPEPSHSSRVREAERLLGLGFEGIEDDDDAGFGAGAIPHSLTSASTALQGLLRKLGAGLDDILPSSALSAAAAAAAASSSSASGQLGGRLKKILAGLRADGEDGRQIEALTQLCEMLSIGTEESLGAFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCSAVVHYGAVPCFCARLLTIEYMDLAEQSLQALKKISLEHPTACLRAGALMAVL... | 65 |
Q0WJZ4 | 2.7.1.107 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600829-1" | MANQSTGLTRIYKAAGYTVKGLTAAWNNEAAFRQESVAAVIAIILAFWLDVGAIARILLICSVVLVLIVEVINSAIEAVVDRIGSEFHALSGRAKDMGSAAVFLTILMALFVWITVLWQHVAR | 83 |
Q00526 | 2.7.11.22 | ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH | 102 |
A0A0R0F5Q2 | 1.1.1.100 | ACT_SITE 227; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MASIAGSNCVALRTANFGASGNRKIGQIRQWSPILTNLRPVSGLRHRSNTPFSSSGVRAQVATLEEAGTGATQKVEAPVAVVTGASRGIGKAIALSLGKAGCKVLVNYARSSKEAEEVSKEIEEFGGQALTFGGDVSNEADVESMIKTAVDAWGTVDVLINNAGITRDGLLMRMKKSQWQDVIDLNLTGVFLCTQAAAKIMMKKKKGRIVNIASVVGLVGNVGQANYSAAKAGVIGLTKTVAKEYASRNITVNAVAPGFIASDMTAKLGQDIEKKILETIPLGRYGQPEEVAGLVEFLALNQAASYITGQVFTIDGGMVM | 2 |
A0A803T1X8 | 2.7.11.25 | ACT_SITE 233; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MERKREVKSEFSEEGWAWNTGPMTPNPVWMAVFDYEATAEEELTLRRGDRVEVLSKDSTVSGDEGWWTGKLQDKVGIFPSNYVTSNHKYTQIQGSLTCPPPLEISFQELELDEIIGVGGFGKVYKGLWRGEEVAVKATRQDPEEDIAVTAENVRQEARLFAMLQHPNIIALKAVCLNLPHLCLVMEYARGGALNRALAGKKVPPHVLVNWAVQIARGMNYLHNEAIVPIIHRDLKSINILILERIENEDLSSCTLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRHSLFSKSSDVWSFGVLLWELLTGEVPYREIDAL... | 105 |
Q9BWV3 | 3.5.4.5 | ACT_SITE 400; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01083" | MKEAGQMQNLESARAGRSVSTQTGSMTGQIPRLSKVNLFTLLSLWMELFPAEAQRQKSQKNEEGKHGPLGDNEERTRVSTDKRQVKRTGLVVVKNMKIVGLHCSSEDLHAGQIALIKHGSRLKNCDLYFSRKPCSACLKMIVNAGVNRISYWPADPEISLLTEASSSEDAKLDAKAVERLKSNSRAHVCVLLQPLVCYMVQFVEETSYKCDFIQKITKTLPDANTDFYYECKQERIKEYEMLFLVSNEEMHKQILMTIGLENLCENPYFSNLRQNMKDLILLLATVASSVPNFKHFGFYRSNPEQINEIHNQSLPQEIAR... | 187 |
F6I559 | 2.3.1.286 | ACT_SITE 124; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSLGYAEKLSYIEDVGKVGMSEICDPLHVLQEKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKALPQASLPFHRAMPSMTHMALVELEKAGILKFVISQNIDGLHLRSGIPRDKLAELHGNSFMEICSSCGIEYLRDFEVETIGLKETSRRCSNVDCGAKLRDTVLDWEDALPPKEMNPAEKHCRMADVVLCLGTSLQITPACNLPLKSLRGGGKIVIVNLQETPKDKKASLVIHGFVDKVIAGVMDRLNMRIPPFVRIDLFQVILTHTLSSDKRFVNWILRVASVHGQKAPLPFIKYVEVSFLDGQNYKEAVLH... | 58 |
A0A1U7ZZM0 | 1.11.1.7 | ACT_SITE 86; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKALVFLYLLAFGFWTLGATADHMDGEETESPHGDQGDYHQQYQGLSFDYYSSTCPQAETLIAETLKDIVSKDIRVPARMIRMHFHDCFVRGCDGSILLDSTPGNKAEKDAPPNNPSLQGFEVIDKLKAVLENNCPGVVSCADILAYAARESVYLAGVDRYRIRGGRKDGRVSKDTDALANLLPPFAQVSTLIQGYAAKGLSVQDMVTLSGAHTVGVSHCSSIVGRQANFSNTGKPDPTLDPHLASVLRVECQSNNGSDNIVVMDRFTPLVLDNKYYVGLLQNKGLFTSDQTLLTIEVTRNEVMENAYKPGVWEQKFIAS... | 14 |
U5GA92 | 3.1.1.11 | ACT_SITE 254; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRIKAISFWLLAFAIALVSIVIALYEISPSPSTGTPISNLHSSSLTTLKRVIKKSGLEVFHSLVASSFSRHHHRRKHKIKCDMNKWISSRLIYRYKVSLVLTVDLKGCGNFSSIQEAVDVVPELSSSTTLIIMDSGTYREKVTVHAKKTNLILLGQGYLNTAIAWNDTANSTGGTVYSASVAIFASNFIAYNISFKNTAPWPSPGEVGGQAVALRIAGDKAAFYGCGFYGAQDTLHDDSGRHYFRGCFIQGSIDFIFGNARSLYQSCTISSIAEQPKAGVSGSITAQARQSVSEQTGFSFVNCTVIGSGKVWLGRAWGAY... | 125 |
A0A0A0K5V8 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKLMILLNLLLFLGCFASISQAQLKFGFYARSCPTAKSIVRSVVNDAIRNDATMAAVLLRLHFHDCFVEGCDGSILVDNGARSEKLAFGHQGVRGFDVIEKAKRELEAQCPGLVSCSDIVAMAARDAIVTANGPDYDIPTGRRDGRVSDVSLASDLPDVSDSIDVLKRKFAEKGMNEKDLVLLSAAHTIGTTACFFMTNRLYNFPGGGSDPNINPALLPELQSQCPRNGDVNVRLGIDRDTPRTFDISIFQNIRSGFAVLASDASLNNDPSTRAILDSYLSPLAPVLGPSFQRDFVTSIVRMGQIGTKTGSEGEIRRVC... | 14 |
Q8EDM4 | 2.4.2.1 | ACT_SITE 204; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01627" | MTAHINAQPTDFAETVIMPGDPLRAKYIAETYLTDAVEVTNVRNMLGYTGYYQGQRISVMGHGMGISSMVLYGHELINFFGVKRIIRIGSLGATQQHVEMRDVILAQAAGTDSPTNAKRSSGYHMATSATFSLLHKAYTKANEKGISVKVGNVFSGDLYYDPDEDMIPALERFGVLGIDMEVAGLYGLAHQQGIESLAILTVSDHCLTGEETTAQERQLSFNNMIELALETALN | 75 |
Q39202 | 2.7.11.1 | ACT_SITE 657; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGSLSCSIIHLVLILQLQTFFVFSQNIRNGSVPVGESLTASESQQISSSWRSPSGDFAFGFRKIQPNDGFTLSIWFDKISDKTIVWHAQAVNTTTGLVPNGSKVTLTADGGLVIADPRGQELWRALSGGSVSRGRFTDDGNFVLFRDGSEDSDEVLWSSFENPTDTLLPNQNIEVGRNLSSRRTETSFKKGRFSLRLEDDGNLQLHSLNAETASESDIYSQYYESNTNDPNNPGIQLVFNQSGEIYVLQRNNSRFVVKDRDPDFSIAAPFYISTGFLLSTIIPKEARRIVGGCLLGLCRDNMCSPDDALGNMACGYNNIC... | 99 |
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