Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q9FGL5 | 2.7.10.1 | ACT_SITE 788; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MRLKNFPFFVLFFFFCFNSNQSWGLMSSNQQPQFFKLMKNSLFGDALSTWNVYDVGTNYCNFTGVRCDGQGLVTDLDLSGLSLSGIFPDGVCSYFPNLRVLRLSHNHLNKSSSFLNTIPNCSLLRDLNMSSVYLKGTLPDFSQMKSLRVIDMSWNHFTGSFPLSIFNLTDLEYLNFNENPELDLWTLPDSVSKLTKLTHMLLMTCMLHGNIPRSIGNLTSLVDLELSGNFLSGEIPKEIGNLSNLRQLELYYNYHLTGSIPEEIGNLKNLTDIDISVSRLTGSIPDSICSLPNLRVLQLYNNSLTGEIPKSLGNSKTLKI... | 97 |
A0A067F2L2 | 1.1.1.205 | ACT_SITE 324; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 420; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MDFSPLPIEDGFSADRLFSQGYSYTYDDVIFLPHYIDFPIDAVSLSTRLTRNIDLSLPCVASPMDTVTEDYMAAAMAALGGIGIVHSNCTAADQARLVVSAKSRRVPIFSSSLDVFKAPDGCINDANDFDGSNYVFVTESGTRRSRILGYVTKSDWENLSDNKVKIFDYMRDCSSNVSVPANYDLGQIDEVLEKNDVDFVVLEKDGERLDVVTREDVERLKGYPNLGKGTVGPDGKWMVGAAIGTRESDKERLEHLVKAGVNVVVLDSSQGNSSFQIEMIKYAKKTYPELDVIGGNVVTMYQAQNLIEAGVDGLRVGMGS... | 3 |
P42750 | 2.3.2.23 | ACT_SITE 85; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MASPSKRREMDMMKLMMSDYKVDTVNDDLQMFYVTFHGPTDSLYQGGVWKIKVELPEAYPYKSPSVGFVNKIYHPNVDESSGAVCLDVINQTWSPMFDLINVFESFLPQLLLYPNPSDPFNGEAASLLMRDRAAYELKVKEYCEKYAKPEEILSDDDDDDSMSEDGSDSDDDDDDEIVGKADP | 64 |
Q8KA27 | 2.2.1.2 | ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MNQLNALKQFTTIVADTSDIESICKYKPQDATTNPSLILKAVSSSVNKRFIDQAIEYARKKGGSYNYKIVNASDKILVDLGVEILKHIPGYISSEVDARLSFNKEKCILKAKKIIDMYEEKGISRNRVLIKLAATWECIKAAEELKKNNIACNLTLLFSFAQARACAESNVFLISPFVGRIYDWYLSQNLILKNPADQDPGVLSVCKIYDFYKKYNYKTIIMGASFRNVQQILSLSGCDRLTISPVLLKELESSNKELNRKLCPPTSFLNPPVPLTEAEFRWEHNQDEMAVQKLSEGIRNFGKDQLSLEKIFSKLI | 52 |
Q7USD8 | 3.2.1.52 | ACT_SITE 340; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MRRTFISFRRARFVLSQSILQLASKSLDTIYRYDPKFVFASLIPHPKLNRLPMLVRCLLAYLLLASTTFIAAAEVSIVPLPAKVEPGDGANLILPSMITVESPPISGWSDHLEIFGEHLERMTAGKHQLQTSDANNPVLLISHTPNLSPEAYTLSITQKQIQIEASSIKGFAHSTATLLQLIGGSRSDSIPPMRIEDAPKLSYRNFMIDMGRNPHSLALLKEAIDLLWFYKIDSVQLHLTDDQRIAFPSTAFPKLWDGKITLPEFKELERYAVQRGVTIIPELEVPGHSELLRRNYPEVFGKTGTDLTKSPKAIEGIKTL... | 170 |
Q39041 | 3.2.1.26 | ACT_SITE 135; /evidence="ECO:0000255|PROSITE-ProRule:PRU10067" | MASSDALLPISAREEEPLCPYTRLPMADPNQETHGPRRRRPFKGLLAVSFGLLFIAFYVALIATHDGSRSNDEGIDETETITSRARLAGVSEKRNDGLWKLSGDRNTPAFEWNNSMLSWQRTAFHFQPEQNWMNDPNGPLFYKGWYHFFYQYNPNAAVWGDIVWGHAVSRDLIHWVHLPIAMVADQWYDSNGVWTGSATFLPDGSIVMLYTGSTDKAVQVQNLAYPEDPNDPLLLKWVKFPGNPVLVPPPGILPKDFRDPTTAWKTSEGKWRITIGSKLNKTGISLVYDTIDFKTYEKLDTLLHRVPNTGMWECVDFYPV... | 164 |
A0A8J0PNS4 | 2.1.1.37 | ACT_SITE 78; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MALRVLELYSGVGGMHCGLAESGVAAEVVAAVDVNTNANKVYKYNFPHTPLWPKTIEGITLKELDALSFDMILMSPPCQPFTRIGLQGDISDPRAKSFLYVLDILPRLKKLPAYILLENVKGFESSEAREALIGTLQKCGYVYQEFLLSPTCLGIPNSRLRYFLIAKLQTEPFAFPISNTILEEFPSQHSIDPGRRRVIHCSENNPQAGADQKNPSCPFSGTDHGPEKTFLYKLETAQELERKQGQDNDASVRMLQDFLETSVEEMSQYFLPPKSLLRYALILDIVRPTCRRSTCFTKGYGHYVEGTGSVLQTATDVEID... | 47 |
K7LCD5 | 3.1.1.11 | ACT_SITE 359; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRTQELVVTFLVLGCALTWVSMSDGLVGGHQEHAHNECNLTRYPNLCAETLMELGLGNQNVDNNIEALVNKTIFETSLPSSYFAEFKTGEAQPAHSVVADYCEELMSMSLKRLDQSLRALKSPKRNTNDIQTWLSASLTFQQSCKDHVHAHTSTLSTDDHLMERMSNKMDYLSQLGSNSLALVNQMSTTTSHNIGDNNNEKEHEFPIWVSSKGRKLLQGATIKANAIVAQDGSGNYKTVSEAIEAASGTTRFVIYVKEGVYKEKINTNKDGITLIGDGKYSTLIVGDDSVAKGAILPDSATFTITGDGFIARDIGFHNNA... | 125 |
P14682 | 2.3.2.23 | ACT_SITE 95; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MSSRKSTASSLLLRQYRELTDPKKAIPSFHIELEDDSNIFTWNIGVMVLNEDSIYHGGFFKAQMRFPEDFPFSPPQFRFTPAIYHPNVYRDGRLCISILHQSGDPMTDEPDAETWSPVQTVESVLISIVSLLEDPNINSPANVDAAVDYRKNPEQYKQRVKMEVERSKQDIPKGFIMPTSESAYISQSKLDEPESNKDMADNFWYDSDLDDDENGSVILQDDDYDDGNNHIPFEDDDVYNYNDNDDDDERIEFEDDDDDDDDSIDNDSVMDRKQPHKAEDESEDVEDVERVSKKI | 64 |
F1MTV1 | 3.2.1.35 | ACT_SITE 149; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MRMLRRHHISFRSFAGSSGTPQAVFTFLLLPCCLALDFRAPPLISNTSFLWAWNAPVERCVNRRFQLPPDLRLFSVKGSPQKSATGQFITLFYADRLGYYPHIDEKTGKTVFGGIPQLGNLKSHLEKAKNDIAYYIPNDSVGLAVIDWENWRPTWARNWKPKDVYRDESVELVLQKNPQLSFPEASKIAKVDFETAGKSFMQETLKLGKLLRPNHLWGYYLFPDCYNHNHNQPTYNGNCPDVEKRRNDDLEWLWKESTALFPSVYLNIRLKSTQNAALYVRNRVQEAIRLSKIASVESPLPVFVYARPVFTDGSSTYLSQ... | 166 |
Q9I441 | 3.4.21.89 | ACT_SITE 40; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 83; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MGLLAAIMLAVYLANPFGTASLDPRARLLGVALYKIPSRSMEPTLQQGDFILANAARYAFADPQVGDLVVFRFPPQRSIAYVKRIAGIPGDRVRIDGGRLYVNERPVTEPYLAQQALRQPESLRMAERTVPAGQYFMLGDNRDNSNDSRYWGYVPRADLVGRVFAVWYAEDTRRIGSVR | 178 |
Q0JEU6 | 2.7.11.1 | ACT_SITE 645; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MAHLLFLPILQLLLLYCTKSAQAQLNISIGSSLTPQGVNNSWISPSADFAFGFLAVDGNSSSYLLAVWFNKIADKTVVWYARTSSNGKDDTIPVQVQSGSVLKLADGALSLRDPSGNEVWNPQVTDVGYARMLDTGNFRLLGTDGATKWESFGDPSDTILPTQVLSLGTALHSRLLATDYSNGRFQLKVQRDGNLVMYPDAVPSGYLYDPYWASNTVDNGSQLVFNETGRIYFTIINGSQVNITSAGVDSMGDFFHRATLDTDGVFRQYVYPKNIHARPLWPEQWTAVDVLPENICQSIQTMVGSGACGFNSYCTIDGTK... | 99 |
I1LB85 | 3.1.1.11 | ACT_SITE 423; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGEDGQSKRRIAIIGVSTIFLVAMVVAVAVGVNYFNLNGGSNDDAHDDKSQIASSVKAVKTLCKPTDYQKECEKSLRAEAGNTTDPRELIKIAFKITIKKMGNGLKKTDFMHEVENDPRSKMALETCKQLMNLSIDEFKRSLERMGKFDLNNLDNILNSLRVWLSGAITYQETCLDGFKNTTNKAGNKMKNLLKSTMHMSSNALAIISELADTVVKVNVTTKDIGHRQLVEDSGDEHVFGQHKVIPSWVEDEEDGVGVGVRRLLHESAYKIKPNVVVAKDGSGKYKSINQALKKVPEKNQKPFVIYIKEGVYHEYVEVAK... | 125 |
Q9QZL0 | 2.7.11.1 | ACT_SITE 143; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:10490590, ECO:0000305|PubMed:24095729" | MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPECPRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRSSGRNL... | 99 |
A6K134 | 2.3.2.26 | ACT_SITE 161; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MYFSIYWDQRDVDLIPDGISVPVNETNKRDYVSKCVDYIFNISIKTIYDEFHRGFYKVCNRDSIRHFQPEELMAAIIGNPTCDWKQFENNSKYENGYSKSHPTILLFWKAFHELTLDEKKKFLLFLTGCDRLHVKGLQNEGIRFRCPEVFSERDNPRSLTCHSILDLPKYSTMRRMKEALQVAINNNKGFISPE | 65 |
O81291 | 2.7.11.1 | ACT_SITE 475; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MFFIKLFTIFFLSFFWQSLKSSSQIIDFTYNGFRPPPTDISILGIATITPNGLLKLTNTTMQSTGHAFYTKPIRFKDSPNGTVSSFSTTFVFAIHSQIPIAHGMAFVIAPNPRLPFGSPLQYLGLFNVTNNGNVRNHVFAVELDTIMNIEFNDTNNNHVGIDINSLNSVKSSPAGYWDENDQFHNLTLISSKRMQVWVDFDGPTHLIDVTMAPFGEVKPRKPLVSIVRDLSSVLLQDMFVGFSSATGNIVSEIFVLGWSFGVNGEAQPLALSKLPRLPVWDLKPTRVYRFYKNWVPLISLLLIPFLLIIFLVRFIMKRRR... | 99 |
Q86UE8 | 2.7.11.1 | ACT_SITE 592; /note="Proton acceptor" | MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQN... | 99 |
Q03019 | 3.1.3.48 | ACT_SITE 318; /evidence="ECO:0000250" | MASKRLMLDVEEEDDESGACGQENFDPHDADMEYQAKRRKSAVQETPLQWMLKRHIPASTTVLSPITELSQNMNGARLDGTPKSTQRIPANRTLNNFNSLSSRTLGSFSSSCSSYESGNSLDDEYMDMFEMESAENHNLELPDDLEVLLSGQLKSESNLEEMSNKKGSLRRCLSMYPSEQPEEAVQEPDQETNMPMKKMQRKTLSMNDAEIMRALGDEPELIGDLSKPCTLPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAFPTLTSNQENRRIYVFHCEF... | 149 |
Q81F30 | 1.8.4.11 | ACT_SITE 15; /evidence="ECO:0000256|HAMAP-Rule:MF_01401" | MSEKTYELATFAGGCFWCMVKPFDELPGIHKVLSGYAGGHVENPTYEQVKAGTSGHLEVVQITFDPSIFPYQKLLDLYWPQIDPTDDGGQFFDRGPSYRTAIFYHNETQKGLAEKSKQALAESGMFKDPIVTEIRPAAPFYEAEEYHQHFYKKNPEKYATEQKESGREDFIKENWQKK | 39 |
Q5KAI7 | 2.3.2.26 | ACT_SITE 1021; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFDPAFLLSNSKSNNVNLSTSTSTSSSDLLSSVRAERLAREEKRHQELAAIEIQKVWRGRKVARDFRERILDDLERSLGIEGGLNVEKGGREMVVLLRDAKNKKDTDRKQIVSANWCDLGLQVKDGRPNLVEPLNRDPGWGRILGLLSIRLLHVVDCNPTTVHVPSILSGLEAIADPSSYTGFPAQLADTARYEWLEAILNNQWVDKLVSILSKLISASLPKKKHPSISPIIRLLASPLSAASPSQLAPVLAPMVNQLFAIPNLPSSLPLQALTYLSANFHIFDIVIPFASQNPQILTEGRLSDELGKTYFLANLVTFGI... | 65 |
Q7PS31 | 2.3.1.181 | ACT_SITE 181; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MSRLVHVLRAGRLPYQRALKLQQTIASQLQQQQQNASPSPPYRHVLILTEHEPVYTIGIRTRGYDETEENRLRALGADFVRTNRGGLITFHGPGQLVAYPILDLKHFQPSVRWYVCHLERTVIELCRRYGLRAGTTADTGVWIGDRKICALGIHASRYVTTHGLALNCDVDLGWFGHIVPCGLVGKSVTSLAHELGNRPDLGVDSVADGLLECFRATFECELDELDAGSRTKLLEGI | 55 |
Q9KR20 | 5.3.1.8 | ACT_SITE 272; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MTNPIQNYAWGSKTALQQLFELENPNDDPQAELWMGAHPNGCSGIAINGKIVQLSDFIAQNPNLILGEYTARQFGELPYLFKILAAEKALSIQVHPNKQQAERGFAQEEQLGIALTAAQRNYKDPNHKPELVYALTEYQAMNGFRANQEILNYFIELSIDEIQPLVNVFQSNPTEQGLRDFFSGLLSLQGEAKNRALEALMAQAKQIDLPLFQLIVELENQYPNDIGLFAPLMLNVITLQPGEAMFLDAETPHAYLHGTGLEIMANSDNVLRAGLTPKYMDIDELVACTQFKHKPLEQLRLKPEVIEGCEQYPIPVADFK... | 214 |
A5JME7 | 4.1.1.50 | ACT_SITE 73; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 87; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 236; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MEMDLPVSAIGFEGFEKRLEISFVEPGLFADPNGKGLRSLTKAQLDEILGPAECTIVDNLSNDYVDSYVLSESSLFVYSYKIIIKTCGTTKLLLAIPPILRLAETLSLKVQDVRYTRGSFIFPGAQSFPHRHFSEEVAVLDGYFGKLAAGSKAVIMGNPDKTQKWHVYSASAGTVQCNDPVYTLEMCMTGLNREKASVFYKTEESSAAHMTVRSGIRKILPKSEICDFEFEPCGYSMNSIEGAAVSTIHITPEDGFSYASFESVGYDPKTNELGPLVERVLACFEPAEFSIALHADVATKLLEHVCSVDVKGYSLAEWSP... | 196 |
Q5A1Q0 | 5.1.3.15 | ACT_SITE 159; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 264; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MPVEELEDRVIITDPNDSTNRATILKFGATVVSWKNNNQEKLWLSEGAHLDGSKAVRGGIPLVFPVFGKQKDSNHPTFKLPQHGFARNSTWEFLGQTQESPITVQFGLGPENVDPETLKLWNYDFTLILTVSLTKDKLVTSIDVENTGKEAFEFNWLFHTYYRIHDITDTLVTNLIDQQCYDQLIGESYIEKAPVISFHEEFDRIYSKVSLEKSIQVVDKGQVLFNLHRKNLPDSVVWNPWTKKAEGMADFQPKSGFHQMVCVEPGHVNSMVSLPAGGKWSGGQEITIGGEIKVQANIY | 210 |
P49657 | 2.7.12.1 | ACT_SITE 292; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MYRLEDTNSGGVMDKNKQKLSAYGSSGGSVDAAQGSGSGGGRQRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLG... | 107 |
Q69Q47 | 2.7.11.1 | ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGGEEGMAAGRKKRVGRYEVGRTIGQGTFAKVKFAVDADTGAAVAMKVLDKDTILNHRMLHQIKREISIMKIVRHPNIVRLNEVLAGKTKIYIILELITGGELFDKIARQGKLRENEARKYFQQLIDAINYCHSKGVYHRDLKPENLLLDSRGNLKVSDFGLSTLAQKGVGLLHTTCGTPNYVAPEVLSNNGYDGSAADVWSCGVILYVLMAGYLPFEEDDLPTLYDKITAGQFSCPYWFSPGATSLIHRILDPNPKTRITIEQIREDTWFKKTYVAIKRGEDENVDLDDVQAVFDNIEDKYVSEQVTHNDGGPLVMNAF... | 99 |
F6WR85 | 1.8.1.4 | ACT_SITE 487; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MQMFRNLYSNLIKKNSTNLSSNVLRQPYFIRASNYSSQTHDADLVVIGSGPGGYVAAIKAAQLGLKTVCVEKEATLGGTCLNVGCIPSKALLNNSHYYHMATGKDFAMRGIDDTAEVKLNLPKMMEQKSTAVTGLTSGIAGLFKANKVTRVDGHGIIKGPNQVVAKKADGGEETINTKYILIATGSEVTPFPGIEIDEETIISSTGALSLKEVPKRMIVIGAGVIGVELGSVWSRLGSQVTAVEFLGHVGGMGIDMDVSKTFQRTLQKQGLKFKLNTKVTSAEKTASGIQVNVESAKGGKAETLECDVLLVCIGRRPYTN... | 36 |
Q10664 | 2.7.12.2 | ACT_SITE 195; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSGKRRNPLGLSLPPTVNEQSESGEATAEEATATVPLEEQLKKLGLTEPQTQRLSEFLQVKEGIKELSEDMLQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPVPAPSQAEYATMFNVAENEIELADSLEEPNYHPPSNPASMAIFEMLDYIVNGP... | 108 |
P65235 | 2.7.6.1 | ACT_SITE 196; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MAAYDSLMVFTGNANPELAQRVVRHLDISLGNASVSKFSDGEVAVELLENVRGRDVFILQPTCAPTNDNLMEILTMADALKRASAGRITTAIPYFGYARQDRRPRSVRVPISAKLVANMLYSAGIDRVLTVDLHADQIQGFFDIPVDNIYATPILLNDIKQQRIENLTVVSPDIGGVVRARAVAKSLNADLAIIDKRRPKANVAEVMNIIGDIQGRTCLIVDDMIDTANTLCKAAVALKERGAERVLAYASHAVFSGEAVSRIASSEIDQVVVTDTIPLSEAAKNCDRIRQVTIAGLLAETVRRISNEESVSYLFNEEVM... | 114 |
Q8IXL6 | 2.7.11.1 | ACT_SITE 458; /evidence="ECO:0000269|PubMed:23754375" | MKMMLVRRFRVLILMVFLVACALHIALDLLPRLERRGARPSGEPGCSCAQPAAEVAAPGWAQVRGRPGEPPAASSAAGDAGWPNKHTLRILQDFSSDPSSNLSSHSLEKLPPAAEPAERALRGRDPGALRPHDPAHRPLLRDPGPRRSESPPGPGGDASLLARLFEHPLYRVAVPPLTEEDVLFNVNSDTRLSPKAAENPDWPHAGAEGAEFLSPGEAAVDSYPNWLKFHIGINRYELYSRHNPAIEALLHDLSSQRITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAAFHLDRI... | 99 |
A7EFT9 | 5.1.3.15 | ACT_SITE 192; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 299; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MDRPKKPSALSATPALTPHPQINTTHSNSRVSAVLPTGESIEILLYGATIISWKDAAGTEKLWLSEKAALDGTKAVRGGIPLVFPVFGKVEGEEGKAKGVDTLPQHGFARNCRWEFLGKSTSESTLKGQEGGSSVKLDFGLSASNLPEETRKLWGGEFGLIYSVTLGKESLGTSMVVRNEGTTAWEFQILMHTYLKIQDISQISINGLENATYVDKLTEPISTNTAPSEPLTISAKTDRVYTPAGGPSTEIIVSEGGKKKYTVARDNMNQVVVWNPWIDAKDIGDFAPKDGWRTMICVEAGSVTGWQKLEAGETWEGGQI... | 210 |
A9UTP3 | 6.3.4.4 | ACT_SITE 16; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 44; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125" | MAQQKVAVVLGLQWGDEGKGKLVDVLAEDADVVARFAGGNNAGHTVVVDNISYDFHLLPSGIGHAKCDCVIGNGVVIHLPGLYEEVEKNMAKGPHLQGWQSRLKISDRAHLVLDLHQKVDGMKEEERGLDKIGTTKKGIGPTYSSKAIRHGLRVCDLMGDFGIFKQKFLQVVEHYQKLFPSLEVDVDAQLKAFEGYAEKVRPMVTDTTLLVHRYLKENKRVLLEGANATMLDLDFGTYPYVTSSSCCVGGICTGLGLPPQAVGDVYGVVKAYTTRVGDGAFPTEDFAEVGNYLQTKGHEYGVTTGRKRRCGWLDMMVVNY... | 253 |
Q8TSH7 | 1.1.1.37 | ACT_SITE 174; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P61889" | MAKISVIGAGNVGATTVQRLAELEPGEIVMTDIVEGLPQGKALDLMQAGAINGYDTQVTGTNDYADITDSDLVIITAGIARKPGMTREDLMKTNSKIIGEVSRNIAEYAPNSIVINVTNPLDVITYVAMKTTGFETKKVFGMSGVLDAGRFASFIAEELNCSKKDIEAMVIGGHGDLMVPLPQYTTVSGIPLPELLPEETIARLVERTVNGGAEIVGLLKQGSAFYAPSAAIVSVAEAVLKDSKRILPTSAYLEGQYGQEGIYFGVLAKLGANGVEEVLELKLEENQYEILRKSSETIKRGISKLGI | 5 |
Q9HFW2 | 2.7.11.1 | ACT_SITE 644; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSLSAAARELSESDFQDIGPAPKPPPVAYNQTKPLVNYMSQMDLGAKSGGKMRAVQRKKSGWVSYKDDGLLSFLWQKRYMVLNDNYLSLYKGDSGREDAVVQIPLTSIVSVSRNQLKQNCFEVVRSSDRSGAPAAGAGGDSSKKSVFIATKTELDLHTWLDSIFSKCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPFNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYNNGTATPTAQAAAQAAGAPGRPPMLTLSSNSSQASMQQIASTPPYSGGEMIPQRKAPTPPKPVVTSGSAIPSAKGGPNVGVTTSPSVH... | 99 |
Q75KG4 | 4.1.1.50 | ACT_SITE 67; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 81; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 249; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MASCGFEGFEKRLELVFELPASGGEVARHGLRLLPAEALREVLDAAQCAVVSAAGNAAADAYVLSESSMFVYPGRVVLKTCGTTPLLRAVPVLLRAAAALRLRLRSCRYSRGEYLFPEAQPFPHAHFADEVAYLDAALPRELLRFRRSAVMPSSSSSSPGASHRWHVYSASSSASSSDADGAARLTAEVCMTELDRGMAARFYQRPGDGRTSHAIGDEMTAASGIGGVVDENDPRSLVCAYAFAPCGYSMNALDGARYATVHVTPEDGHCYASFECATDDAAAALAAIRRAVAAFRPATVSVSISHTSSAASSLCTPVAE... | 196 |
P75393 | 1.8.1.4 | ACT_SITE 437; /note="Proton acceptor"; /evidence="ECO:0000250" | MNYDLIIIGAGPAGYVAAEYAGKHKLKTLVVEKEYFGGVCLNVGCIPTKTLLKRAKIVDYLRHAQDYGISINGQVALNWNQLLEQKGKVVSKLVGGVKAIIASAKAETVMGEAKVLDPNTVEVAGKTYTTKSIVVATGSRPRYLTLPGFAEARQNGFVIDSTQALSLEGVPRKLVVVGGGVIGIEFAFLYASLGSEVTILQGVDRILEIFDTEVSDLVAKLLQTKNVKIITNAQVTRANNNEVFYSQNGQEGSVVGDRILVSIGRIPNTECLDGLNLQRDERNRIVLNQDLQTSIPNIYIVGDANAQLMLAHFAYQQGRY... | 36 |
F4NZD5 | 3.2.2.27 | ACT_SITE 121; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MTITKKRTDPPRLESDAKIRRLTDSENINPSDTEKVTADDTVLANKLSETQPLLQLEITTMPDDWFNAFRSEMESAYFLNIKRFLQAERDAKKVIFPLLENIYSFTQCPLKKIKVVIIGQDPYHGLHQAHGQCFSVQKGVSIPPSLINIYKELESDLGLDVFKRPSHGYLNSWCQQGVLLLNASLTVRQSEPNSHAKCGWLKFTDAIIAYINKNNQGVVFMLWGGFAQKKGTVVDKKKHLVLKATHPSPLGANKGGWFGCKHFSKANEYLKSKGRGVVDWASITRD | 173 |
D8RCK2 | 1.1.1.37 | ACT_SITE 209; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MNFRAAGIFRATAMEASKLVLRRAFARSASSAKRRVVILGANGGIGQPLSLLMKLSPLVSDLGLYDIVGTPGVAADVSHVNSRAQVAGFAGEENLGKCLKDADLVIIPAGVPRKPGMDRDDLFNVNAGIVQTLCTAVAKNCPKALVNIISNPVNSTVPIAAEVFKKSGTYDPNRLFGVTTLDVVRARTFLASAKKLNPSEVDLPVIGGHAGATILPLFSQASPKVSLSTKELDALTKRTQDGGTEVVKAKAGKGSATLSMAYAGALFAEACLKGLNGVNNVIECTYVESSVVPGLSFFSSKVRLGKEGVDEILELGSLSD... | 5 |
A0A2K1J8B0 | 3.4.19.12 | ACT_SITE 82; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 157; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSWCTIESDPGVFTELIQQMQVKGVQVEELYSLELESLSQLRPVYGLVFLFKWRAGEKDGRPVLKDYNPNLFFASQVINNACATQAILSILMNRPEIEVGPELSTLKEFTRGFPPELKGLAINNSEAIRTAHNSFARPEPFVAEEQKVADKDDDVYHFISYLPVDGVLYELDGLKEGPISLGECGGEGPDSMDWLQMVQPVIQERIEKYSKSEIRFNLMAVIKNRKDIYNEEMTQLEMRRARLWDRIEKLEGKRDDTMDVDSGDEEVGPVSIDKLRNEFADVESELAKVQDKIAMEDEKFRKWKTENIRRKHNYIPFLFN... | 175 |
A0A9R0K7A8 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARATTLAILVLCMTLVGQSYGQLKQGFYNGRCGTNNVENIIYSIVANAYQYDKTLVAALLRLQFHDCFVRGCDASILLDVSNSEKTAIPNGSVRGYELIDSCKTKLEQLCPGVVSCADIIVIATRASVLLAKGSWYNVETGRRDGFISIADEALNNLPGPAISVADAVTSFGNKGLTADDFVLLLGGGHSVGIIHCVHFLDRLYNYKNSGRADPSMNTATLSSFRQRCPSTGSTNFVYADQTVGSEFLVDNGFFKAIEQRKGVIEIDQRIESDTLTANTVNRLAYSTDFASQFGGAMVKLGRVGVLTGSQGQVRKSCRR... | 14 |
O84350 | 3.1.26.11 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01818" | MSYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIFISHFHGDHCLGLGSMLMRLNLDRVLHPIHCYYPASGKKYFDRLRYSTIYHETIKVIEHPIDREGIVEDFGNFRIESRQLDHLVDTLGWRITEPDTTKFIPEKIKAAGLKGPIMQELINKGQVKVNDTIVHLDDVSYTRKGDSIAVVADSLPCQAIVDLARNARILLCESTYLEEHSHLAKSHYHMTAKQAAEQAKRAEVQQLILTHFSARYNTTEEFVQEAGEIFPNVFAAEEFCSYEFPKNPS | 137 |
Q9KUI8 | 2.1.1.77 | ACT_SITE 59; /evidence="ECO:0000255|HAMAP-Rule:MF_00090" | MANPKADRLIQFLTEQGITSPQVLAAIHALPREFFVAPAMMHQAYDNNALPIGQGQTISQPYIVAKMTELLALTPETKVLEIGTGSGYQTAVLAKLVNHVFTVERIKTLQWDAKRRLKQLDIYNVSTKHGDGWQGWPARGPFDAILVTAAAAKVPQSLLDQLAEGGRMVIPVGEDEQYLYKIVRQGGQFISERVEAVRFVPLVAGDLA | 49 |
A0A022R301 | 5.1.3.15 | ACT_SITE 188; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 293; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MSEESLETVSPFTAPPPPVQQRPTCKAAVRADRGGPYIILRQPNGYSAEILIYGAQVISWKNERQQELLFLSKKAVYRPPHPIRGGIPICFPKFFGKENMDKHGFARIRLWQTETLADDAVFPLPTPDNAYVDFVLNHMPRDFPDWPNHRFELRLRVILGPTGDLTMTSRVKNVNTNGEPFTFKFAYHTYFSVSNIRATQIEGLQTLDYLDYLEDHEQLTDEADAITFEDELDRVYLNTPDDIFVTDRELRRTITIHKDASLPEIVVWNPWDIEARDMDDLGDEEYREFVCVEAAAMESEITLNPNEEWTGTQRLSVEEY... | 210 |
Q8RHM2 | 2.7.6.1 | ACT_SITE 197; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MINFNNVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASAKTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRVVAMDLHADQIQGFFDIPLDHMQALPLMARYFKEKGFKGDEVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNMSEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGAKEVYACCTHAVFSDPAIERLEKSVLKEIVITDSIALPERKKIDKIKILSVDSVFANAIDRITNNQSVSELFN | 114 |
B7QGN3 | 3.1.3.1 | ACT_SITE 101; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | SLCPLMCPVPEVPEDLEPKYWVQHGQDTLKRLLETDVVDAPAKNVIVFVGDGMGISTVTASRIYGGQLKGHRGEESSLSFERFPFTALVKTYAVDKQVTDSAASATALFCGAKTKYTMLGVSAMANISECDSLAGHEMDSFIKRAQDKGMSTGLVTTTRVTHATPAALYTHSVHRDWENDARVPKDAVHKCKDIARQLIEDVPGKNLNVRGEEKKGASGITQQNLVCRDKQTGGGKRGDGMNLIEDWKRSKQNRKFVTNREELLAVDTNATDYLLGLFADDHMAYELHRQEGSLKQPSLVDMVTTAVKLLRRNENGFALM... | 141 |
Q81BY0 | 1.11.1.6 | ACT_SITE 65; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 138; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MNEKYDKHRKELLEEDFNKHRELTEPAKFHSQTVGSRGPVLEQDSVLHESLQQFIHEKILERPVHVKGFGAFGYFQTIYSMSEHTKLSFLQNSNEKVPVMVRFSLAVSTKGTPDTARNVRGFSTKFYTKEGIFDLLCNHIPVFSVRDPMRFPETIQALLPSPKNNLIDPNRFWSFVAKAPESIHFVVRLYSNNGTAKSLRHIPGHSVNTYVWRNAEGNRKYVKYHWYPFEGVQYITSKEAIKLAAENPDYSGKDLYDAIENGKPVEYGLYVQLMDPKDETHLSYDPLDDTKVWDEQTYPLIPVGKMVLNKNPENFMEQVE... | 13 |
P46795 | 1.2.1.12 | ACT_SITE 153; /note="Nucleophile"; /evidence="ECO:0000305|Ref.3" | MKLAINGFGRIGRNVFKIAFERGIDIVAINDLTDPKTLAHLLKYDSTFGVYNKKVESRDGAIVVDGREIKIIAERDPKNLPWAKLGIDVVIESTGVFSSATSDKGGYLDHVNHAGAKKVILTVPAKDEIKTIVLGVNDHDINSDLKAVSNASCTTNCLAPLAKVLHESFGIEQGLMTTVHAYTNDQRILDLPHSDLRRARAAALSIIPTSTGAAKAVGLVLPELKGKLNGTSMRVPVPTGSIVDLTVQLKKKDVTKEEINSVLRKASETPELKGILGYTEDPIVSSDIKGNSHSSIVDGLETMVLENGFAKILSWYDNEF... | 22 |
A0A0A0L530 | 4.1.1.50 | ACT_SITE 64; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 78; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 236; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAESGFEGFEKRLELHFTGNEPIIHMGLRQIDLSSLEQILRTVHCSIVSSVGNHFFDAYVLSESSLFIYPTKIIIKTCGTTQLLKSIFPFLHQARSLGLTLSSCRYTRGNFIFPKSQPFPHSSFKEELLYLEESLPENLHYRKASVIPSNLPSHSWHVFTAADDAALIHRNPEFLYTVEICMTELDRILARKFYFRSGDGKAGNSIGKEMTNLTGIGDINPSGLVCEFAFFPCGYSMNGIDGDRYSTIHVTPEDGFSYASFECVGSVYDDPDDLVRMLKKVVQIFRPAAMSVATTGASHEVWALVAGALDPLGLKCRSCA... | 196 |
Q9NES8 | 3.1.3.16 | ACT_SITE 303; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:P53041" | MAATITDDIVATVLESIEEKSYEDEKEKAGMIKDEANQFFKDQVYDVAADLYSVAIEIHPTAVLYGNRAQAYLKKELYGSALEDADNAIAIDPSYVKGFYRRATANMALGRFKKALTDYQAVVKVCPNDKDARAKFDECSKIVRRQKFEAAISTDHDKKTVAETLDINAMAIEDSYDGPRLEDKITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPTGKKFTICGDVHGQFYDLCNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNHESDVMNKMYGFEGEVKA... | 144 |
A0A5F5Y789 | 3.2.2.27 | ACT_SITE 260; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03166, ECO:0000256|PROSITE-ProRule:PRU10072" | MGMDRGAHGTNQTRGGRPARPAVQSERTRGGSPKGFCREKTTWGRRWRVRGGGAPGSRPPSPGTPPEVSRALLPASLPAAVWYATQNWGQRPAFPAGLPHSVFAATCPLAAASSRMGVLRNGPWGWGRQLRAPGPGPLRLVTSLRGDRLQASPAKKARAGQEDPGTPPTSPLSPEQLVRIQRNKAAALLRLAARNVPVGFGESWKKHLSAEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQMCDIRHVKVVILGQDPYHGPNQAHGLCFSVQRPIPPPPSLENIYKELSTDIDGFVHPGHGDLSGWAKQGVLLLNA... | 173 |
D2A0T2 | 3.1.3.3 | ACT_SITE 18; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 20; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MSGEVQKILKNADCVCFDVDSTVIQEEGIDELAKFCNKGAEVANLTAKAMTGTMTFQESLKLRLDIIQPTLTQIRDFLKTKPPTLTPGVKNLINLLHSRKIPVYLISGGFKCIIAPIAAQLNIPYDHIYANRLKFYYSGEHAGFDENAPTSRSGGKAVVIDFLKKQHNYKNVILIGDGATDLEASPPADGFIGYGGNVIRPTVQAKAKWFVTDFNEVIDVLNQ | 147 |
Q54QV3 | 2.7.12.1 | ACT_SITE 332; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGSTTQMSDYLVSTTTTSSASSMVTMTSQIENNSLNSNDNTNTTNNNNNNNNNNNNNNNNNNNNNNNNNINNNNNNGGMVGVNHKTHKKTASIGGGKNRAILHDFTFSYFIPNQNRSEDNSNENELGLNNHNVQHQGPIIHLTKNLLHFYKKCNSNFNYISSLNPRRVLTHPSEPLSNDGYDNVNSDYIVYVNDIITNNESGQKYKVLDSLGQGTFGQVVKCKNCDTDELVAIKILKNKQAYFQQGRLEIQTLKSLNDQHDPEDKNHILRLLDSFIHKMHLCIVFELLSVNLFELIKQNNFRGLSTNLIKVFLIQILDAL... | 107 |
Q9RR60 | 4.2.1.11 | ACT_SITE 203; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 335; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MNIEKVIAREVLDSRGNPTVEAEVHLDSGFSGRAIVPSGASTGSHEALELRDGGERYMGKGVERAVQNVREALGPALIGMDASEQAAIDKALMDVDGTSNKGNMGGNAILAVSLATARAAAAELDIPLYRYLGGSNAKTLPVPMMNVINGGAHADNSVDFQEFMVMPVGAPSFREALRYGAETFHHLKKVLSGRGYNTNVGDEGGFAPDLKSNEEALEVLLEAIQQAGYEPGKDICIALDPAVTELYKDGQYHLESEGRVLSSDEMIDFWADWTSRYPIVSIEDGLAEDDWDGWERLTAKVGAKTQLVGDDLFVTNPERL... | 200 |
A0A251SF04 | 3.2.1.14 | ACT_SITE 127; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MNTYRMLIFAGVLLAGILNSAAQNCGCSPNLCCSQWGYCGSGDDYCGPGCREGPCYSTSDVDVGSIVTDAFFNGIVDQSDAGCEGRGFFTRAAFLEALGNYAEFGSASSEDGSRREIAAFFAHVTHETGHFCYINEINGASRDYCDELNTQYPCNPNKDYYGRGPLQLSWNYNYGAAGNAIGFDGLNNPEIVATDPLMSFQTALWFWMNNVHSVIGQGFGATIRAINGMECDGGNPSTVSARVEYYTRYCSQLGVTPGDNLWC | 158 |
H9GFQ0 | 3.1.1.3 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 194; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 284; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MFGIWFTAFLLHVIVRGSEICFDRLGCFENGPPWGGTLQRPTLDFPEPPDIVNTAFHLYTRENPIYFQVISAVNPSTIKVSNFRTNRKTRFIIHGYFVGDEYDRIVNICRFLLQKEDINCIVVNWKGAAADLYTQAVQNIRIVGAEVAYLLEYLEENCGYSLSDVHIIGHSLGAHAGGEAGRRKPGLSRITGLDPAGPLFHQTPPEVRLDPSDAKFVDVIHTNIGHLFFDFASGIIQPCGHLDFYPNGGGIMPGCKKELFISKQGGIDGAMREIASSRSAGCSHKRSLRYYSDSIFIPDGFLGYQCKTFDSFASGKCFPC... | 128 |
A0A5F5PV42 | 3.1.1.3 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 194; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1"; ACT_SITE 281; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR000865-1" | MGNIWTIVLFLLGAAKGKEICYDHVGCFSDSEPWAGTAIRPLNVLPWSPERIGTRFLLYTNENPDTFQSLLPSDPSTVEASNFQADKKTRFIIHGFIDKGDESWLLDMCKNMFKVEEVNCICVDWKKGSQTTYTQAANNVRVVGAQVAQMLGMLSANYSYSPSQVHLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEASFQGTPEEVRLDPSDAVFVDVIHTDAAPLIPFLGFGTKQQMGHLDFFPNGGEEMPGCEKNALSQIVDLDGIWAGTRDFVACNHLRSYKYYSESILSPDGFAAYPCDSYRAFESNKCFPCPDA... | 128 |
C5WUE6 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAMGKQQGAGLLFLVVVAGLLLHDTRVADAQTLRVGYYNQTCRNAESIVADEVLKASYRDKGVLASLIRLHFHDCFVNGCDGSVLLESSDRQAEKNAKPNLSLRGFDVIERIKQRLEAACALTVSCADIVAFAARDSVKLSGGVGYAVPGGRQDGTVSRASMTGDLPPPNQRSVDQLAQYFYRKGLTLDDMILLLGAHSLGVAHCGTFDYRLTSDQDKGMDAAFRNSLRSQCRHNASNAVPFDAGSPYAFDTGYFANVLANRTVLESDAALASPRAAGKVRQWKDNPGWFRSSFAAAMVKMGSIRGTNPGKVRLSCNRVR... | 14 |
Q59989 | 3.1.1.29 | ACT_SITE 21; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MIPKLIVGLGNPEPKYDQTRHNIGFAVVDALAITWQCSWYDHKRFQGWFGEGLMAGQKTCLLKPRTYMNRSGQAVRAVVDWYKLDPQSVLVVYDDMDLPLGRLRLRQTGSAGGHNGMKSLISHLGTQDFPRLRLGIGKSDGSKDTIAHVLGKFSPSELPIVEKSLDLATEAIAHSLHHGIAKTMSLFNNRDVCP | 127 |
A0A0K9PJJ7 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGYSTLFKAFSLCFLWFILYDAKISSAHAHAHAHDNSMLKYGFYSKTCPNAETIVRITLSNYVKQDVTVAAPVLRLHFHDCFVRGCDGSVLLNSTKNNKAEKDATINLTLDGFYVIDAAKAALEEACPGVVSCADIVALAARDAVYLSKGIYYEAQTGRRDGRVSHASEAAVKIPNSFSGFEELKANFAATGLDVKDLVVLSGAHTIGQSHCQNFAKRIYNYTGKGGDDDVDPTLNPNYIPILRKQCKPGDTTTTVDMVPGGSTTFDNDYYGLVNRNKGLFHSDAALLSNDETKAYVYTHRYSDQSNKSAFFQDFAVSMV... | 14 |
A0A1U8MVG3 | 1.11.1.7 | ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MFYKQLLKNQVQGKMEIGQRVLLCLHIQLIIVVMVLNHSNAQGLKLGFYSETCPNAESIIRKTTYGFISRAPTLAAPLLRLHFHDCFVRGCDGSVLLNSTKNQAEKDAIPNLSLRGYHVIDAVKSAVEQACPGVVSCADILALVARDSVSMINGPSWKVPLGRRDGRVSKLSEALANLPSPFFNITQLKQNFASKGLNMKDLAVLLGGHTIGTSHCVAFGLRLYNFSGKGDADPSMDLTYVTQLKQKCKPGDITSLVEMDPGSFKTFDEAYYTLVSKRRGLFGSDAALLNNAETKAYVLQASRHGSTFAKDFAVSMEKMG... | 14 |
A0A804I122 | 3.2.1.52 | ACT_SITE 342; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MESTPSILFFLVFVVIVNVISLVSSSDAAPLIEINVWPKPISVSWSGPAAIAVPLSPSFRVLNPYSEHPYLCAAAARYTRLLLLERYRPLRPPHLNLSSSAPPLSSLALSVVDPSAPLRHGVDESYTLSITANGSSSVAELSAATPWGAMRGLETLSQLAWGNPPAVAAGIRIEDRPLFPHRGLLLDTSRNFYPVRDILRTIRAMSHNKLNVFHWHITDSQSFPLLLPSAPQLALRGSYGPDMRYTPADVRRVVRYAMNRGIRVIPEIDAPGHTASWAEAYPEIVTCANKFWSPPDGPALAAEPGTGQLNPLEPETYEVV... | 170 |
Q8Y014 | 2.2.1.2 | ACT_SITE 125; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MTQLDQLKQFTTVVADTGDFQAMRAYAPHDATTNPSLILKAVQKAEYRPLLEQAVRDARSDSVEDIIDAVLVAFGCEILSIIPGRVSTEVDARLSFDTAATVAKARHLIALYEARGVPRERVLIKIASTWEGIRAADQLRAEGIRCNMTLLFSLIQAVACAEAGVQLISPFVGRIYDWYKKDAGAAWDPIAQGGANDPGVQSVVRIYNYYKRFGYTTEVMGASFRNTSQIIELAGCDLLTISPELLAQLQQSDAPVERKLSPEHAHATNLVRLPADEAAFRWHMNADAMATEKLAEGIRLFAADAVKLEGLIGPLRAAA | 52 |
A0A2K1IMY1 | 3.1.3.48 | ACT_SITE 94; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MREVREGIYIGDLGDAAAVKASEVPLVSHVLSLVGSSSSLLDSKTSAHTQGAENLHKLAVPMLDEDSQNLLDNLESCLEFIEKGRSRGGVLVHCAAGVSRSAAVVTAYLMQKEHLSAAAALKSLRRISPGVHPNDGFMEQLAIFESMGNKIDRDSSSYKKFKVKFLGESFAKGEVMESSSYASDPGSATVKLPAPSNTIESGTERSTVYRCKKCRRVVARDENVIGHDVGGGESAFKWQKRGGKEGMYTQAPVCTSMFVEPMQWMTAVEEGVVEGKLQCVKCEARLGNFNWSGMQCSCGAWVTPAFQLHKSRMDAAYF | 149 |
H3GNU0 | 2.7.11.1 | ACT_SITE 565; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MGRKKGKKRANKLNVHLGCSVFRSADACVQDAPATYDAATLAEARELQAQELEVLQAIFDRDLVSQSATPLYTYIFAIRLACEATPGSATTAEVLLHFDLARAYPLQQPPNITVEPKHGLSDTETQKLQRGMEALALEKVGDAVVYDLVVFATDFIQEHLKDQSSFFDQMMTRQQDRETREKQEEDALLQEQEAQARAKNEEIIALIDAERKKRETIKKTRRRRRRHRSSIDGEYSGSDGESLSSIYEQQTEASSRRDGSSSSLSDSDSDTSDLDAAAAAERYHSRYHGDFKELGLLGRGGGGEVVKVRNRLDRQLYAVK... | 99 |
A0A1L8EXP1 | 3.1.1.4 | ACT_SITE 161; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 206; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MEFRILALIFLFHCLCITANESDVSNEIVDPLCDGNISENCIQGNLTQEDWMDQKEVKAPCITANGSDISGTIMDPMCDRNISEEYHNGNLTEEDWMDEMALNGSFRKPHNLQKRGLIQLTKAIRCVTGRSSLRYLGYGCHCGPGGKGGPIDATDWCCHAHDCCYKESKRHRCKPKIGSYKWSCSNRTFHCPAQSSWCKSFVCNCDREFSRCISRARFNSILILYPNGRCRKPPQPCR | 130 |
Q5JE70 | 3.1.26.11 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01818" | MLEVFFLGTGGIMPTRERNVPAIALRYKGEIILFDAGEGTIRQMNTAKLSPMKVDKIFITHFHGDHYLGIPALIQTMNLWDRQKPLHIYGPKYTFQFVQNLLNSGFFRPGFDIHVHELGETRLKFGDYEIWSFKVEHGIPALGYVFKEKDRRGKFLKEKLREYGLEEGPILGKLEREGKIEWNGRIIRLEDVTGPRRKGLKIVYTGDTEPCERVKLFSERADLLIHEATYLNPGDRGDSYHSTVEEACDTARRAKVKLLALFHRAFRYSYEDYVEEALKICESLGVRAVVPRDFDVITFKSGTWELRNLLEERE | 137 |
Q5ZCI1 | 2.7.11.24 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MQQDQRKKSSTEADFFTEYGDASRYKIQEVIGKGSYGVVCSAIDVHTGEKVAIKKIHDIFEHISDAARILREIKLLRLLRHPDIVEIKHIMLPPSRRDFKDIYVVFELMESDLHQVIKANDDLTKEHYQFFLYQLLRALKYIHTANVYHRDLKPKNILANSNCKLKICDFGLARVAFNDTPTTIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAEVLTGKPLFPGKNVVHQLDLMTDLLGTPSMDTISRVRNDKARRYLSSMRKKEPILFSQKFPSADPLALDLLQKLLAFDPKDRPTAEEALAHPYFKGLA... | 104 |
A0A2C9W4S3 | 3.1.1.11 | ACT_SITE 388; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLHFHAPSFAITSLPQSHCSSLHYSAFHRMSRFSVPLLFVFLLLVLIVGSVPCDASSRSRSDYLQNECLKVPISEFVGSARTTIVLIRNVASTISKFGNFLGNFRLTNAIADCLDLLDFSADELSWSMSASQNPKGKHNSTGDLSSDLRTWLSAALVNQDTCIDGFEGTSSILKNLVAGGLNKITSSVQQLLSKVDSKPNSKANGVALTGRKTSQNHKFPSWVQHRDRKLLVINGVTPDAIVAADGTGNFTKIMDAVSAAPDYSMGRYIIYIKKGFYNEYVDIKKKKWNLMMVGDGMGVTVISGNRSFIDGWTTFRSATF... | 125 |
A0A8M2BJ34 | 3.2.1.52 | ACT_SITE 338; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MLCLLKFTPLFLVVAVCHGWLFGDLFEKQKELDEISLWPLPQKYQSSAVAFKLSAASFQIVHAKQSTAGPSCSLLENAFRRYFEYMFGELKRQEKSRKKAFDSDLSELQVWITSADPECDGYPSLRTDESYSLSVDETSAVLKAANVWGALRGLETFSQLVYEDDYGVRNINKTDISDFPRFAHRGILLDSSRHFLPLKVILANLEAMAMNKFNVFHWHIVDDPSFPFMSRTFPELSQKGAYHPFTHVYTPSDVKMVIEFARMRGIRVVAEFDTPGHTQSWGNGIKDLLTPCYSGSSPSGSFGPVNPILNSSYEFMAQLF... | 170 |
G1KU09 | 2.7.10.1 | ACT_SITE 986; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MSCRANWMDILGKAWTFSALLVFCGSSFMLSGVVEATFDLILINSLPTEVDSETSLICITSRWCSLDSIKIGRDYDALMNQHPSPLTVVENETKGVSKKVVWQREKSGESIGVYYCEGKCRDKVKRIHTMKMQQTASFLPVSLTITANKRDDVNITFVKKEVKEEDAVIYKNGTFIYSVLRQEVPKLLKYSISQVSLQDAAVYSARYIGGNHFTAAYTRLIVRRCEAQRWGPECSFHCPDCNNGGICHEDTGECICPPGFMGKTCEKACAENSFGRACQERCEEKSGCKSLVFCLPDPYGCSCASGWKGLHCDEACEPGF... | 97 |
Q9JZB5 | 1.1.1.205 | ACT_SITE 305; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 401; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1" | MRIVEKAYTFDDVLLVPAHSTVLPRDVKLQTKLTREITLNLPLLSAAMDTVTEARLAISMAQEGGIGIIHKNMPPEMQARAVSKVKRHESGVVKDPVTVAPTTLIREVLEMRAQRKRKMSGLPVVENGKVVGIVTNRDLRFENRVDLPVSAIMTPRERLVTVPEGTSIDEARELMHTHKVERVLVLNEKDELKGLITVKDILKTTEFPNANKDSEGRLRVGAAVGTGGDTEERVKALVEAGVDVIVVDTAHGHSQGVIDRVRWVKETYPHIQVIGGNIATAKAALDLVAAGADAVKVGIGPGSICTTRIVAGVGVPQLTA... | 3 |
A9A3A9 | 2.7.7.7 | ACT_SITE 112; /evidence="ECO:0000255|HAMAP-Rule:MF_01113" | METRIVFHIDFDYFYAQCEEIRSPELKSKPVCVCVFSDRGGDSGAIATANYTARKYGAKSGIPIVFAKKRLEERKDAVFLPVDFDYYSEMSEKAMKIMEEFSDVFEYVGRDEAYLDVTKRTEGDFHKASHLAQQIKNSIREKTKLSCSIGISPNKLISKIASDFQKPDGLTIVSPEKVEGFLESLKIRDIPGIGKKTEQRFTEMNLETIGDVKRLDVFTLNKEFGRKSGTYIYNAVRGIDDELVKEREPSIQHGKIVTLKKDSKDYEFLLENTLELCKEVHEIIQKKNQMFKSVGISFVQSDLSNKTKSKMLRNPTMSLE... | 121 |
K7DYR4 | 3.1.1.4 | ACT_SITE 68; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 112; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MQLILLCIILITSGGMAPSQGSLLQLKKMIRQATGKNPIFSYLNYGCHCGPGGRGQPIDATDWCCKAHDCCYEHLAEQKCYAHLDVYKYKYVSGDIECYGKSHCEKEICQCDKELALCLRRNLETYKKQFCLSWLFFCQGENPEC | 130 |
E9HBA1 | 1.11.1.24 | ACT_SITE 57; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR637944-1" | MALRSTLRSSILSKVPESLVGLNFTVFGRKELHLASTFNMPIKVIIVGVSGAFTPCCSKTHLPGYVSDFEKFKSKGIDEIVCVAVNDPYVMDAWGKDLNTNGKVRMLADTNGAFAKAANLEKDLSGTLGNVR | 12 |
Q09740 | 2.6.1.16 | ACT_SITE 2; /note="For GATase activity"; /evidence="ECO:0000250" | MCGIFGYINYLVERDRGYILKTLVKGLKRLEYRGYDSSGCAVDGDEGEDFIMFKEVGNVSKLEASIKGSNVNKSTKFINHCAISHTRWATHGIPSPINCHPQRSDPHSEFIVVHNGILTNYRELRTVLESRGMVFESETDTECVAKLAKFIYDTTPGVDFTSLAKLVFRELEGAYALLIKSSHYPGEVVATRRGSPLIVGVKSEQKLKVDFVDVEFPEPAEGLPGTPKPTSLHPVFSNPATNGMLRGDKPDLLHRAQSRAFVSGEGVPGPIEYFFASDATPIIEYTKRVMFLEDDDIAHVRDGELHVHRLRREGGGSTTR... | 81 |
Q5M9B2 | 3.1.1.3 | ACT_SITE 43; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MKHFNLSFSAAGFLGIYHLGAASALLKHGPKMVKRVKCFAGASAGSLVATVLLTAPDKIKESKEFLYAFSEDVRKQKVGAMTPTYDFMKNLRGGIESILPANAHEIAEHRLYVSITNAKSRKNCLVSHFASREELIKVLLASSYVPLYAGIKAIDYKGEKWFDGGFTDSLPLLPTGRTITVSPFSGRIDICPQDKTHWDLYVTFAKHSLLLSAANVRRLNQALFPPRQEKMETIFQDGYKDAVNFLQLKNWYEHC | 128 |
A0A1U7ZI92 | 2.3.1.286 | ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSLGYAEKLSYREDVGTVGMSEIFDPPDLLQQKIEELAMLIKKSKHLVVFTGAGISTSCGIPDFRGPKGVWTLQREGKGVPEASLPFHRAMPSVTHMALVELEKAGILKFLISQNVDSLHLRSGIPREKLSELHGNSFRELCPSCGAEYLRDFEVETIGMKETSRRCSDVNCGAKLRDTVLDWEDALPPKEMNLAEKHCRMADVVLCLGTSLQITPACNLPLRSIRGGGKVVIVNLQQTPKDKKANLVIHGFVDKVIAGVMHLLNLRIPPYVRVDLLQISLSQFSRSTEERYVKWTLRISSVHGQKAPLPFLESVEISFS... | 58 |
A0A2K1IJE7 | 3.4.21.89 | ACT_SITE 151; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 201; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MAMIVGAGRISVVGFAIDVDAQFKAAASVGSGQLCCRGPALRNPFVGQTLKIAVRCWSRSEQQRRYEALVARSERDRNGREGEPLAAPAIKESPSEEDAVDAEEAELKKPSWLPDWAAISSDDGKTILAAFAFSLLFRWFIAEPRFIPSLSMYPTFEVGDRIVAEKVSYYFKQPSVNDIVIFKAPESLQAKGYSAGEVFIKRIIAKAGDVVEVHNGQVFVNKQPKNEPFIAEPPIYDMKATYVPEGFVFVMGDNRNNSYDSHIWGPLPVKSILGRSVVRYWPPTRLGSTVLEPEAPGVRLTPVLPLLQAQSAMRPS | 178 |
A0A1L8GM27 | 2.7.10.1 | ACT_SITE 872; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MVLHLFLPFVFFFSLLLVKTGAVLDVTLVSLGTRATDFSLRCVTGERDMHGSDLHIRRDNSIVRTTPKTQFKIASGSNDVRAHGFVINELVGVLICTGKGPAEQTEILYVNNFPNADLIPVKVTVTVSVNSDVTLEAKINRHELADILWKYNGTMFHTTYKGEVTDKTAQLNMQAVKVSHAGIYSAGFMGASPLNNAFFRLIVRGCPDNKWGPSCQKDCRECLNGGICHDSSGECICAPGFMGTRCEKACREGNFGRNCQEMCKGEHGCRGRTFCLPDPYGCSCGSGWTGSHCQKSCPPEKYGANCALHCQCKNGGSCNS... | 97 |
Q7NFK0 | 2.7.1.23 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MMALPKAGIIFNDIKPAAARAAAELTEKFQDAGYRVYQTTGWGGILGFPRPDSPVCHTPIDRLAAEGFDEAMPFAIVLGGDGTVLAAARQVAPFDIPLLTINTGHMGFLTEGYLNQIHPAIDTLLAGQYALEDRSMIEVRVFRDERLIWEALALNEAVLHKEPLSGICHFEVAIGRHNIVDIAADGVIVATPTGSTAYALSAGGPVITPDVQVLQLIPICPHSLAARGLVFADTESLVVHPPTNHQHLILSLDGNSGCYIWPGDQVRIRRARYRTRLIRLQPPEFFALLREKLGWGLPHIAKPLSVELP | 89 |
A2FR71 | 2.3.2.26 | ACT_SITE 638; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSSAAATSTKEAVQQLFNQFTNGCDSINCKCKWCKSCSNFPFKFNSPNEIASKVLDLLKTTPFAEMVCPNLKTESPEKVVDIKAAIRSSDKEQIQNAFKRLFTEVEYFPYLFASKSQPIRKGNYQFESSDFKSFLAYLSHNLEMIESFRNDYYNLVEKIIANDSKTYTRIRSIILAFCFDNFLLFHTENQISQKFFFMIDNLSDEEVTVLIDMFSSIPPVLLNSLMVCQTIITVLSHESFSSNKYYDFIKYACKMVKHLHYASLCSEAQLPYHAFFNDPLSKFFIKRNEIADFTPYLGALSLSLKARCMYREIMDKQRMT... | 65 |
A0A804JBQ1 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAALSSSLLLLFAAHFLTTSFSLELNFYRDSCPRAELIVKEVVQKHCQKDPSVPAGLIRLHFHDCFIKGCDASVLVDSTDYNIAEKEAPPNLTLRAFDVIDDIKAEVEKECRGVVSCADILALAARDGVALSGGEAYPLPTGRRDGTVSLMEDAHFPGPSFSVQAALSAFQTINLDLVDLTTLLGAHSIGLCHCGFFIDRLYNFRGSGLADPHIDPGLLDTLRHKCPFEVVEIKNVSKDPKVFMNQAAAASSSPFTLNTSFYRGLLDYRAVLRLDQNLAFTDFTSRLAASYVDDPKLFLAQFSKSMIKLGSVGVLTGRDG... | 14 |
P91938 | 1.8.1.9 | ACT_SITE 569; /note="Proton acceptor"; /evidence="ECO:0000269|PubMed:17385893" | MNLCNSRFSVTFVRQCSTILTSPSAGIIQNRGSLTTKVPHWISSSLSCAHHTFQRTMNLTGQRGSRDSTGATGGNAPAGSGAGAPPPFQHPHCDRAAMYAQPVRKMSTKGGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASLLGEAVHEAAAYGWNVDEKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGSFVDSHTLLAKLKSGERTITAQTFVIAVGGRPRYPDIPGAVEYGITSDDLFSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTV... | 37 |
B9N486 | 3.1.1.11 | ACT_SITE 183; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEHPLFIILVTLFIITSRGISQVSDCKPGNNGSKVAITIVVDQSGMGNFRAIQEAIDSIPANSDQWIKVQINPGTYTEQVAIPIDKPCIFLEGQDSSLTTITYDAHERTDLSATFASRPTNIVAKGITFKNSFNLGAVPAVSAVIYGDKTAFYNCAFLGFQDTIWDALGRHYFSNCYIEGAVDFIFGVGKSFYEGCSINVTGDGFITAQGREFPFETNGFVFSNCTVTGLQGFQAYLGRAYRPYATVIFQSTFLSEVVRPLGWDAWQYPGQESNFTFAEIDCKGPGSDTSKRVPWEKKLDGSQLEKFSKSSFIDRDGWLA... | 125 |
A0A1U8LEH1 | 3.1.1.11 | ACT_SITE 403; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASKLICSILMICHLVLLPLFIYPSFADSLPSDPVSPGSVCKSTPDPSYCISVLPNQTTNVYNYGRFSVRKSLSQSRKFVNLVDKYLRKYRQSLSVSAIRALEDCRFLADLNMDFLLSSFKTVNATSSTLSNVEADDVQTFLSAILTNQQTCLDGLQSTSSAWSIRNGISVPLTNDTKLYSVSLALFTKGWVPKRKKKATWQPSSSKQLGFKHGRLLMRMWSGTRSIYETVSRRKLLQTNNTDEEVLVSDIVTVSQDGSGNFTTINDAISAAPNNTNGVNGYFVIYITAGVYQEYVSIAKNKKYLMMIGDGINQTIITGN... | 125 |
O13289 | 1.11.1.6 | ACT_SITE 53; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 126; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MAPTFTNSNGQPIPEPFATQRVGQHGPLLLQDFNLIDSLAHFDRERIPERVVHAKGSGAYGVFEVTDDITDICAAKFLDTVGKKTRIFTRFSTVGGELGSADTARDPRGFATKFYTEEGNLDLVYNNTPVFFIRDPSKFPHFIHTQKRNPETHLKDANMFWDYLTSNEESIHQVMVLFSDRGTPASYREMNGYSGHTYKWSNKKGEWFYVQVHFISDQGIKTLTNEEAGALAGSNPDYAQEDLFKNIAAGNYPSWTAYIQTMTEAEAKEAEFSVFDLTKVWPHKKYPLRRFGKFTLNENPKNYFAEVEQAAFSPAHTVPY... | 13 |
P53704 | 2.6.1.16 | ACT_SITE 2; /note="For GATase activity"; /evidence="ECO:0000250" | MCGIFGYVNFLVDKSKGEIIDNLIEGLQRLEYRGYDSAGIAVDGKLTKDPSNGDEEYMDSIIIKTTGKVKVLKQKIIDDQIDRSAIFDNHVGIAHTRWATHGQPKTENCHPHKSDPKGEFIVVHNGIITNYAALRKYLLSKGHVFESETDTECIAKLFKHFYDLNVKAGVFPDLNELTKQVLHELEGSYGLLVKSYHYPGEVCGTRKGSPLLVGVKTDKKLKVDFVDVEFEAQQQHRPQQPQINHNGATSAAELGFIPVAPGEQNLRTSQSRAFLSEDDLPMPVEFFLSSDPASVVQHTKKVLFLEDDDIAHIYDGELRI... | 81 |
Q55A09 | 2.7.11.1 | ACT_SITE 1200; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | METSSNSSGSSSSPPSQHQQQQQQNSQLNLSSQSCFSNNSSSAADFNNYMESKLSEENNYYKNFNSNLDRGDSFKLEKESIKDTIKDNIKEDKICNDNNNSSSSSSSSSSGNNNNNIKDGRAPSPITTQQISPNKLILNTTKAITKPTPILNTQQTPTTTATTNTSTSTTNSTPSKFKKIKNSTINPTIEFISKPSLSVMFGFSPIYFVESIFIVLLIYILSNFVLKETSVYVISIFVIYFVIYFDNRYQIINKLSKSSINDSDSSSNNNNNNNNTTTTNNDSASTKGNNNNEISSPETYQKDVKSKINFYEHVNISSTN... | 99 |
A0A1U8AZS5 | 3.1.1.11 | ACT_SITE 338; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASRPTIILFLYLFSSFSTNSSSAAPSDFVATLKSTIDEVQGVISLVSKFANQFDDFRLSNALNDCVDLLDYSADELGWTLSATENPNSNDNSTGNRNSDLKAWLSAALGNQDTCLDGFEGTNSFVKGLVAGSLDTVTSLVSEVLGQIPSGGRLGRKLKSVSEGGGFPAWMKGSDRRLLQAPAGGVSADAVVAQDGTGQFTSVMDAVLAAPDYSERRYVIYVKRGVYKENVEIKKKKWNLMIVGDGMDVTIISGSRNFVDGWTTFRSATFAVSGKGFIARDITFENTAGPEKHQAVALRSDSDLSAYYRCAIKGYQDTLY... | 125 |
D2A3X3 | 1.11.1.24 | ACT_SITE 49; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MPVPSLQKPAPVFKGTAVVDGQFKEISLKDYSGQYVVLFFYPLDFTFVCPTEIIAFSDRINEFKKIKTAVIGCSTDSHFSHLAWINTPRKQGGLGQMNIPLLADKSMKIAKDYGVLDEEAGVTFRGLFIIDPKGVLRQVTINDLPVGRSVDETLRLVQAFQYTDEHGEVCPANWAPGKKTMVPDPQGSKAYFQESN | 12 |
Q5XD01 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 344; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYLGLGTQKAVDNVNNIIAKAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYTYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGAPTFKEGLRWGAEVFHALKKILKERGLVTAVGDEGGFAPKFEGTEDGVETILKAIEAAGYEAGENGIMIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQVDYLEELVNKYPIITIEDGMDENDWDGWKVLTERLGKRVQLVGDD... | 200 |
A8B2F8 | 2.1.1.33 | ACT_SITE 147; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MLGKADRPDASSSKMARFRHRPHANPLADNDFQFPCTEPDEFPFDLYYPTWTSQRSTDAREYHFDIVDIGCGYGDFVRNVSLAFPDLLVIGLELRDIPVVLGQQALLNGRSAGQNENAAIIRCNIMKHLPRLLARQSVRYLTVMFPDPQFKASHARRRVISPQLLSEYAYYLKSGGFLFVCSDLQDLYLYMCSTIAGHPFFCELQHEEGADDNDGDTRVVKTILKLMDKTADAERHMRKDADKTVYKAVFRCTKPHCM | 45 |
Q8IDF6 | 6.3.4.4 | ACT_SITE 26; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 54; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125" | MNIFDHQIKNVDKGNVVAILGAQWGDEGKGKIIDMLSEYSDITCRFNGGANAGHTISVNDKKYALHLLPCGVLYDNNISVLGNGMVIHVKSLMEEIESVGGKLLDRLYLSNKAHILFDIHQIIDSIQETKKLKEGKQIGTTKRGIGPCYSTKASRIGIRLGTLKNFENFKNMYSKLIDHLMDLYNITEYDKEKELNLFYNYHLKLRDRIVDVISFMNTNLENNKKVLIEGANAAMLDIDFGTYPYVTSSCTTVGGVFSGLGIHHKKLNLVVGVVKSYLTRVGCGPFLTELNNDVGQYLREKGHEYGTTTKRPRRCGWLDI... | 253 |
A9A5D7 | 2.7.1.23 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00361" | MPFLENCLKLQNVAVVSKVGNKESEKAAIDVAKKLLAKKSKVYTISPIQVEGAKQIETLEELKKVKLDLVVTLGGDGTTLRVFRNLENETPILTINVGGNRGILAEITIEEIDDALNQIQKDKFFLDKRTRVVASCGGKEFPPALNEIFINRANLTKTAEIEIKFQNDTVKQKMDGVIVATPSGSTGHSFSLGGPILHESLDVLIITPVAPVYRLESIVVPDEKIEIISSHDCNIVMDAQVVKSAGFEEPITIKKYKKPAVFIRLKKRGLRQMSKLGF | 89 |
U5D2D1 | 1.8.1.4 | ACT_SITE 486; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MAMAACTRRKALILGQILRDCKSNSGHFTSVYTYRSFSSGSEDNDVVVIGGGPGGYVAAIKAAQLGLKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHEAKHSFQSHGVKFSNLEVDLPAMLGQKDRAVSNLTRGIEGLFKKNKVNYVKGTGKLLSPSQVSVDTLEGGNTLVNGKHIIIATGSDVKSLPGIPIDEKKIVSSTGALCLSEVPKKLIVIGAGYIGLEMGSVWGRLGAEVTVVEFAPDIVPTMDGEVRKQFQRTLEKQKMKFMLKTKVTGVDASDSGVRLTVEPAAGGEQTMLEADVVLVSAGRVPYTTG... | 36 |
Q21221 | 3.1.2.22 | ACT_SITE 191; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:Q99685"; ACT_SITE 256; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608"; ACT_SITE 285; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:O75608" | MSSGAPSGSSMSSTPGSPPPRAGGPNSVSFKDLCCLFCCPPFPSSIVSKLAFMPPEPSYTITEDNKLVLIEGRAAWPHQEVDMANCVEMRITRTRRRNRVACTMIRPLPNSHFTLLFSHGNAVDLGQMTSFLYGLGFHLNCNVFSYDYSGYGCSTGKPSEKNLYADITAAFELLKSEFGVPKEKIILYGQSIGTVPSVDLASREDLAALVLHSPLMSGMRVAFPGTTTTWCCDAFPSIEKVPRVKCPTLVIHGTDDEVIDFSHGVSIYERCPTSVEPLWVPGAGHNDVELHAAYLERLRSFIDMEASAIRVTAPITNATS... | 134 |
A0A1S4DJJ4 | 3.1.1.11 | ACT_SITE 404; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNLNVANAYICPYYLDLRIDIINMGIEQFVPKILAFFLIFTFLCSSPFAAPSSFRGPTFCEITPFPDLCKYFLPQNKSTNIHDYGRLSIQLSSSATTQFLDSVNGYLNSKTTSSQSTIFVLQDCQLLIGLNLDFLSNVAGTITQPGNTLQGSQFDDVETLLSACITNQQTCLDSLQITPSAADIASQIFPTLANGSMMYSVSLALFKYGWLPNSPAKTSYSSGSGEMILKTARGGRKLLQMSGISSVNVTQMVVVNPDGSGNFTTINDAIAAAPNNTKAGNGYYMIYVVAGVYQEYVSIASNKKYLMMVGDGINKTIITG... | 125 |
Q8P631 | 2.1.1.33 | ACT_SITE 150; /evidence="ECO:0000250" | MTDPFTSDGAKMPPKPFTIEEGRRQVRSFVLRQGRFTPAQQRAFDELWPRFGLDYTGAPRDLDAVFGRPAPKVLEIGFGNGAALRFAAQHDPARDYIGIEVHAPGVGRLLNALDDDGATHVRLYHHDAVEVLEREIADGALDEVRIYFPDPWHKKRHNKRRLVQPAFAQLLVRKLRDGGRLHAATDWADYAEQMWDVLDATEGLVNRAGPRGHVARPAWRPQTHFETRGQKLGHGVWDLLYDRESGMENRESPGQAPAAPG | 45 |
A0A3B6NTI3 | 3.1.1.11 | ACT_SITE 432; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MLMLCTLPMHLSTHNALLLATMGMHGGTSWRRRTQEAVAVVLALATLGAVAAAVEQHQHETTSKVAGGNAADVSWTEASGVNVTAICSSTPYPGACRMALSSSASRAAKDPFAASVQFAMARAASARVLALNLSSSRRSRAVLPPSGMDDCAELLDISHGLLGDALGAGSAHDATTWLSAALTNQDTCADSLDAVPASSGREGVRQMVGALAEFIGTALALHASLKGGSATPPPSATPTQSSTPSNRAFPSWVSDHDRKLLESAAGGMTPDAVVALDGSGTHRSIGEAIAAVTAAAMAPVGSSKAGAGAARKVIYVKTGR... | 125 |
O44408 | 2.7.11.24 | ACT_SITE 164; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MEVDLPVHNEYDASRFHQVTIRDPIAGADSTFTIPTRYVNLSFLNAGAQGTVVMADDLVTTQRVAIKKMQQPFVMTMSAKRAYREFILLTTIKHPNIIRLLNAFTPDTSLSTFREVYLVMELMTHNLHEVIHRLRLDHKTLSFFVYQSLCAIKHLHNSGVIHRDLKPSNIVVNDRCVLKVLDFGLARKKNVDTSMRMSDYVVTRYYRAPEVILGLPYSEKVDIWSVGCIFAEMINHTVLFPGKDRIDQWTKIYSVLGTPDDHFISQLGQSAAMYVRSLPRHQARAFSEIVPDTNFLPETENPRVHLTPHVARDLLFNMLK... | 104 |
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