Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
Q54R58
2.7.10.2
ACT_SITE 307; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
MFNNDKDDNNQGNENNENNKINIKTSIDMGNYINSSSLVESFGSGSNRNNDKSEDVEYDDDDDDDDDEIASTEEEKESDLDSDSDLAPTQIIVDDSDDFYNNNNGGGGGGGNEDISSTSPTLITSNSFNDKINQIFSRGGSSLNSSFLNNGENKINFKQLVKLKSTLKKHEIPSRELTVEKEIGQGFFGKVYKARWRGKSVALKKITLIKFRDLTETEIFDKEVSIMSKLCHPTCVMFIGACSLDGPSNDRSIIMEYMEGGSLRRLLDEKSSYHLPPSLQLSIARDIAEGMNYLHTNFKEGPIVHRDLTSSNILLNSSYT...
98
M5XQS7
1.11.1.7
ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MDLRAIVVGISLFVFSIGAEGQGLSYNFYENSCPQVEAIVRAALQPIFLADPTAPAALLRLMFHDCQVQGCDASILVDPNENTVSSEMAAGKNFGIRKRESINILKSIVELECPQQVSCSDILVLTAREAVSASGGPQIKVPLGRRDSSVPPSYKLADSLLPSATIGVDGMLQLFAKKGMTVEESVAIMGAHTLGVTHCLNILNRLSRLDQGGRVEGMAPMFEAFLRINCPQGSLTSNASFVLNDPTTLTFDNHYYNNVIRGHGVLRVDAEMVMDPRTALAVKRFAADQDGFFQAFSSAFVKFSSSGVLSGNQGVVRKIC...
14
A0A1U7Z6I7
3.2.1.21
ACT_SITE 182; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 386; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"
MATANDNGETISKEVSRSDFPPDFVFGVATSAYQIEGANNEGGRGDSIWDIFSHTEGKILDGSNGDIAVDHYHRYREDIELMAKLGFDAYRFSISWSRIFPDGLGTKANEEGIAYYNNVINALLEKGIEPYITLYHWDLPSNLHESISGWLSEKIVKYFAIYAETCFASFGDRVKHWITINEPLQTSVNGYCTGIFAPGRTENSLTEPYLATHYQLLAHAAAVSVYRNKFKANQGGEIGITVDCEWAEAFSDKTEDKVAAARRLDFQLGWFLDPIFYGDYPEVMREKLGDQIPKFSEEDKELLKNSVDFLGLNHYTSRFI...
161
A0A0R4IF99
2.3.1.225
ACT_SITE 183; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
MRSWRWSVSRIMRLFLRWFRLCPRRGHRKRSRVRDLWNYGMVVLKSLYYNVQTNSDTVLDCMFEPIYWLVDNMTRWFGVVFVCLVMALTSSVVVIVYLCVLPIIFSSYPVYWILWHLCYGHWNLLMVVFHYYKATTTQPGFPPQEKTDIPTVTICKKCIVPKPARTHHCSICNRCILKMDHHCPWLNNCVGHFNHRYFFSFCLFMTMGCVYCSISAKDMFLDAYNAIESGRYKGGASQGEAVPGAGLIYISFQHQSSYQTPPPAFTHQERMVHKSLVYLWVLTSSVAVALGALTLWHAILITRGETSVERHINRKERRRL...
57
A9V1T6
2.7.11.13
ACT_SITE 460; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
MFSPARSKRGGSVLNLKPLKSSKRTIDPYCIVQLDHTLVGKTTVKPKTESPIWEEVFETNADRAEHIELLCYSKALVGDGTFLASLKVNLADCIEGDSGTTDLWFELEPAGKVKVKIDWAQAVTEPRKFVARANRGRRGAMKRKKIHVVLNHRFVALFLRQPTFCSHCSGFCWGLGKQVCGVVVHKKCHEKVITSCPGGQDKRFNISLPHRFKVHNYFRPTFCDHCGSLLWGLRHQGHRCQACGFNSHKRCLANVAHNCGVDAKAFSDILSEIGTSVSQLDGVRLLPPFSQSKRLSVRCHTRGCRVSPSCPGCCHGATSG...
100
P9WH03
3.1.26.3
ACT_SITE 48; /evidence="ECO:0000255"; ACT_SITE 123; /evidence="ECO:0000250"
MIRSRQPLLDALGVDLPDELLSLALTHRSYAYENGGLPTNERLEFLGDAVLGLTITDALFHRHPDRSEGDLAKLRASVVNTQALADVARRLCAEGLGVHVLLGRGEANTGGADKSSILADGMESLLGAIYLQHGMEKAREVILRLFGPLLDAAPTLGAGLDWKTSLQELTAARGLGAPSYLVTSTGPDHDKEFTAVVVVMDSEYGSGVGRSKKEAEQKAAAAAWKALEVLDNAMPGKTSA
138
Q5BAE9
3.1.1.5
ACT_SITE 1257; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1375; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
MADSGASVPSPDLPDLDSLHASLSLPDIPSVAATSLSTSLPAISAKVSGFPSFSSHLPPPPLLSPPTPTTMVGWIGWVFSLVFQTIPSVLYWVITFSTITLPTWLFTLFSMSLTFTMNFTTLLLIVLGLVSTVSWFIRYRFLNMYSRLPPEPQRKEPQLDLFPDVQEGDSKPGLANYLDEFLSAIKVFGYLERPVFHELTRTMQTRKLIAGETLQLEEEKGFCLVVDGLVQIFVKSMRSGKHGLNGEVIEGSSDEDDQARDGKQGYQLLTEVKNGASMSSLFSILSLFTEDIRLRASEGSSSSMSSVQPSPARTTPAPFL...
131
P95200
1.6.5.9
ACT_SITE 184; /evidence="ECO:0000250|UniProtKB:Q2FZV7"
MTLSSGEPSAVGGRHRVVIIGSGFGGLNAAKALKRADVDITLISKTTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGEVNAIDLKAQTVTSKLMDMTTVTPYDSLIVAAGAQQSYFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEVSTDHAERERRLTFVVVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAPAVLPPMGPKLGLKAQRRLEKMDVEVQLNAMVTAVDYKGITIKEKDGGERRIECACKVWAAGVAASPLGKMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFV...
35
Q4WMU3
3.2.1.21
ACT_SITE 289; /evidence="ECO:0000250"
MRVLSAIALVASLASSALSAPASESRVSTQLRSRDAEGYSSPPYYPAPNGGWLSSWADAYEKAQRVVRDMTLAEKVNLTTGTGIFMGPCVGQTGSALRFGIPNLCLQDSPLGVRNSDHNTAFPAGITVGATFDKDLMYARGVELGKEFRGKGINVLLGPSVGPIGRKPRGGRNWEGFGADPSLQAIGGAQTIKGIQSQGVIATIKHYIGNEQEMYRMSNVGQRAYSSNIDDRTLHEVYLWPFAEGIRAGVGAVMTAYNEVNSSACSQNSKLLNEILKDELGFQGFVMTDWLGQYGGVSSALAGLDMAMPGDGAIPLLGTA...
161
A0A1S4DDU4
3.1.1.11
ACT_SITE 191; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASFFCKTLVFFFMGFVELGNARYISDFQWKQQKMKYTTVYVDPSGHGQFKTIQSAIDSVPQNNQNWICINIKAGQYREQVKIPREKPYIYLKGGDQGKTSVTWDAHDSIATDATFTSEADNTIVESITFINSYNYPPKSNNNPRVVAVAAMISGDKSVFYRCEFLGLQDTLWDVQGRHYFKLCTIEGAVDFIFGNGQSLYESCTISVNARALEGLTGFITAQGRSNPKDESGFIFKNCNVIGSGQTFLGRPWRDYARVIFYGCNMSNVITPEGWTAGVYVGKEKQLTFAEESCKGMGSSTSKRVQWEAKLSQQELQQLT...
125
I1MP39
1.11.1.7
ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATPPNSFCSLFFIYSILLSSFFLAYEAQAYPPVVNGLSYSFYSQTCPKLESIVRNHLEKEFTQASWQAAALLVVFFHDCFVQGCDGSLLLDGNPGERDHPLNRGISLKVLRTIDDLRNVVHNECGRIVSCADITVLAARDAVYLSGGPNFAVPLGRRDSLNFSFEEVNNLPLPYNITSVTLQTFASKNLDVTNVVALVGAHTLGRAHCHTFYNRLSPLDPNMDKTLAKILNTTCPSTYSRNTANLDIRTPKVFDNKYYINLMNRQGLFTSDQDLFTDKRTKGLVEAFAHDQTLFFEKFVDGFIRMSQLDVLTGNQGEIR...
14
Q9SXB4
2.7.11.1
ACT_SITE 634; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MRLHESSSPFVCILVLSCFFLSVSLAQERAFFSGKLNDSETIVSSFRTFRFGFFSPVNSTSRYAGIWYNSVSVQTVIWVANKDKPINDSSGVISVSQDGNLVVTDGQRRVLWSTNVSTQASANSTVAELLDSGNLVLKEASSDAYLWESFKYPTDSWLPNMLVGTNARIGGGNVTITSWKSPSDPSPGSYTAALVLAAYPELFIMNNNNNNSTVWRSGPWNGQMFNGLPDVYAGVFLYRFIVNDDTNGSVTMSYANDSTLRYFYMDYRGSVIRRDWSETRRNWTVGLQVPATECDNYRRCGEFATCNPRKNPLCSCIRGF...
99
Q07497
2.7.10.1
ACT_SITE 762; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
MDSNADISARRVSGMDWLWLVCFFHLVTSLEEILLDTTGETSEIGWTSHPPDGWEEVSVRDDKERQIRTFQVCNMDEPGQNNWLRTHFIERRGAHRVHVRLHFSVRDCASMRTVASTCKETFTLYYHQSDVDIASQELPEWHEGPWTKVDTIAADESFSQVDRTGKVVRMNVKVRSFGPLTKHGFYLAFQDSGACMSLVAVQVFFYKCPAVVKGFASFPETFAGGERTSLVESLGTCVANAEEASTTGSSGVRLHCNGEGEWMVATGRCSCKAGYQSVDNEQACQACPIGSFKASVGDDPCLLCPAHSHAPLPLPGSIEC...
97
A0A0Q3J132
3.2.1.14
ACT_SITE 118; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
AGGGTCANCLCCSRFGFCGSTAEHCGAGCQSQCSGCPRPGPPPPPAGEGVASILSRALFERLLLHRNDAACLARGFYTYDAFLAAAAAFPAFAADAAGITVETRKREVAAFLGQTSHETTGGWPTAPDGPYSWGYCFKQEKEPKSDYCEPKPEWPCAPGKRYYGRGPIQLSYGPGYRIGPAEQPGPVATDPVVAFKTALWFWMTPRNNKSCHAVNIGQWTPTAVDVAARRVTGYGMITNIINGGVECGIGPDPKVVDRIGFYRRYCDALAVSYGNNLDCYNQRPFPSSSSVGFAAQ
158
B8C2X1
3.4.25.1
ACT_SITE 67; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1"
MFGSSLTIGSDILDIGSSKFDRSSDERRGRAVGSGAICPPSLMLGEPGQFEVPNVADVSGVKFAKGTTTLAFKFNGGIIVSVDSRSTMGAYIASGTVKKVIEINPFLLGTMAGGAADCSFWERNLGMQCRLYELRNKKRITVASASKLLANTMSSYRGYGLSMGTMITGWDETGPQLYYVDDDGTRLHGRYFSVGSGSTYAYGVLDTYYRPDLTVEEAIDLGKRAIYHACHRDAMSGSINNLYHVTKDGWVKIHAIDVNDMHYEFLEEKQNAMRSS
180
B7P653
1.11.1.24
ACT_SITE 54; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
VMNMSVFVGKTAPDFTAKAIMPNNNIDDKFKLSDYAAGDNIVLFFYPLDFTFVCPSEIIAFHNKLGEFTERRTKVVAVSVDSHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNEDGVALRGAFLIDKDFIVRHMLVNDLSIGRDINYTLKVIDALTHHQKHGEVCPAGWHKGEEAITPSHEGIAHYLSSHAEKL
12
P73469
2.7.11.1
ACT_SITE 187; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MDLLCTRPGCARLNSFPDLDNRNTLQTVQQRFCTSCRMPLILAGRYLPVKLLGQGGFGAAYLALDRFTPTMRFCVVKQFQPSGNLNQEQLDLALSLFEREAVVLEKLGNRHDQIPDLFAYFPLLVDDPRTGKQDQFFYLVQEFINGQDLEKTVEKHGPLSEAEVRWVLTEMLKILSFVHGTGAIHRDIKPSNLMRDQEGKLYLLDFGAVKQATAGVGASNEGSTGIYSMGFAPPEQMAGNQVYPATDLYALAVTCLYLLTGKTAQDLYDAYHNQWNWRSPGLKVSQPLADVIDRLLLPTPKDRYASAEEVLAVLNGGKGN...
99
Q7F0H7
3.1.1.11
ACT_SITE 394; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSKGAIIGASTVLVVAVVAAVCVVSFKNGGGGKEDGELSTSVKSVKAFCQPTDYQQTCEEELGKAAGNGASSPTDLAKAMFAVTSEKISKAISESSTLEELKNDKRTSGALQNCKELLEYAVDDLKTSFEKLGGFEMTNFHKAVDDLRTWLSAALTYQGTCLDGFLNTTTDAADKMKSALNSSQELTEDILAVVDQFSATLGSLNIGRRRLLADDGMPVWMSEGGRRQLLEAAGPEAGPVEFKPDVTVAADGSGDVKTIGEAVAKVPPKNKERYTIYVKAGTYNEYVSVGRPATNVNMIGDGIGKTIITGNKNFKMNLTT...
125
H2M7J8
2.7.11.1
ACT_SITE 168; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1"
MLLTKLGSFSHICNPSSMDHIPVKILPPVKVEKEPFERVYQVGSVLGSGGFGTVYAGNRISDGAPVAVKHVAKERVTEWGSINGVMVPLEILLLKKVSSSFRGVIKLLDYYERPDGWLIVMERPDLVKDLFDFITEKGALDEGTARGFFRQVLEAVRHCYSCGVVHRDIKDENLLVDLRTGELKLIDFGSGAILKDTVYTDFDGTRVYSPPEWIRFHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGKVYFRRRVSPECQQIIKWCLALRPSDRPTLDQICDHPWMRMASESPKSSEEPAAGEIRLRTIGTDSSS...
99
Q24592
2.7.10.2
ACT_SITE 1014; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSIHTNDGTIRVFNFTTGEFERFHPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCLPGERLNCQLVYCFRMRFRVPELDSQLELIDGRSHKFLYRQMRYDMRTEQIPEIRYPEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPPSLWRAHSFFVGSKIREVFRSLKANSLSVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEVARGSGPIGTSLAHSTSTLASSGSTNTLSTLTTNTNSVALGGSGKKAKRR...
98
D8R4K0
3.2.1.23
ACT_SITE 159; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 242; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SRSFSIENDAFYKDGEPFRILGGEIHYFRIVPEYWKDRIQRAKAMGLNTIQTYVPWNVHEPSEGEFFFGDPVNLEAFLKLAQELEVLVMLRMGPYVCGEWDLGGFPSWLLSKKPQLKLRTSDSSYLKLVDQWWNVLLPKLVPFLYSRGGPLIMLQVENEYGSFGSDKQYLHHLVSDAREYLGNEIILYTTDGATDDALQRGTISRDDVYAAVDFPTGWDPVAAFALQKNYNSPGKSPALSTEFYTGWLTHWGENLATTSPYVAAAELDKLLSANGSVVLYMAHGGSNFGFFSGANTGGKETIYQPDITSYDYDAPIGEGG...
163
Q5KB79
3.4.19.12
ACT_SITE 19; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 115; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 139; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"
MDLVPYMYYEKQEAGSQLCAQHCLNNLLQQYTYSEFDLADIAKRLDQAENATLDVNHQLRKSYNYDDTGYFSISVLERALEVWDLTMVRWRGEAMKPYQDHPEDQAAFILNLASHWFTLRRFAPNPPHAAASKRWYNLNSFLADGPEWISPTYLHMVLTQAEQEGYSVFVIRKATPGTKEGEEAGEAEGWGDGGIGQLPESLGDVMAVELGEPVGRSGGLLSGTIGPTKESKTTQMSIPADPNTTTVDAEPSSPSRPPRRRRQPDLSSDPTEIVDDPYARPAPSRSRQSSSRSNPAQHQVIGDDEGDIFDQTHGIPSHYD...
175
Q5JK35
3.2.1.21
ACT_SITE 192; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 405; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"
MAAAIAVVYLSLLLLLLHGAAPAVLGYTRGDFPEDFVFGSATSSYQYEGGFDEDGRSPSNWDIFTHQGKMPGRSTADVAADGYHKYKDDLKLMVDTNLEAYRLSISWSRIIPNGRGDVNPKGLQYYNDIIDGLVKNGIQVHIMLYQLDLPQVLEDEYDGWLSPRILEDFKAYADVCFKEFGDRVAHWITIDEPNVASIGSYDSGQLAPGRCSDPFGIRKCTVGNSSVEPYIAVHNMLLAHASVTKLYREKYQVAGKGIIGISVYTFWAYPLTNSTVDLEATKRCQDFIVHWVLRPLVFGDYPQVMKNIVGSRLPSFTKAQ...
161
A0A7M7NS38
3.4.19.9
ACT_SITE 130; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MNIFVFSLPLLYILGSAICTYALPLRPIIGVLAQGSSSSIKKYGSSYIAASYIKFLESAGARVVPILVNQTDEYYGNIFKSVNGILFPGGGADIVDDVSRVGYSGAAHILYHLAVQANKQGDFFPLWGICLGFEELMIQTAGTDVLIEGIEAHNVSFPIHLEPGFEDSRLLNKKTTPPSIIHTLTTVNSTLNSHSMGVTPANFTKFPALSSFFRVLSTNHDLNGVKFISTVEAYDFPFYGTQWHPEKNAFEWKVNSCHSKECVELMQFLANFFVEEARKNQHQFSSAEEMAKFLIYNYQPIDLSQSSSFFEQAYFFQ
176
Q5B833
3.2.1.78
ACT_SITE 204; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q99036"; ACT_SITE 312; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q99036"
MRLIHAVLGLLAGAAPALVAASPAAPIGNGRDQVSKAVGRHFEIDGKVQYFAGTNCWWLGNLLNDFEVELAVSQIAETGYKVVRTWGFFGVNDPSNPGQPVYYQVLNESLYEGGLGINYGSNGIRRLDTVVSLAERYDIQLVLTFMNNWNDFGGINIYSNAFGSNATTWYTDKKSQRAYREYIKFIVNRYKGSSAIFAWELGNEPRCKGCDPSVIYNWAKSVSAYIKKLDKKHMVALGDEGWLCPPEGDGTYAYDCSEGVDFVKNLEIETLDYGTFHLYPESWGYNYSWGSEWVLQHDAIGKRFNKPVVFEEYGTPLNHT...
172
A0A0A0KEY2
3.1.1.11
ACT_SITE 223; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MTYCNNALRVTRWILFLEVSAAIILAASHMIPTEKSELDGWYSEHVKSFNKRDKMKLDSELVAAEENATVIKVRGDGSGDFKTITEAIESVPACNTKRVVIWIGGGVYKEKLKIDRNKPFVTLYGSPNNMPNLTFDGDASKYGTVYSATLTVEADYFTAANLIIENSSPRPDGKRKGEQALAARIWGNKVAIYNCKFIGFQDTLCDDRGLHLYKDCFIQGTVDFIFGGGTSLYLNTQLDVVVDGGLGVIAAHSREQESECSGFSFVHCSITGTGGRNTYLGRAWRPRSRVVFAYTTMADIIHPKGWNDMDNFGYDKTVSF...
125
Q9I4L0
2.3.1.286
ACT_SITE 116; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236"
MRAVVELLAGARRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGWYEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVDDLHERAGSRDVLHLHGSLHAPRCATCAAAYRDALPDSVEPEEGRRIEPPRCPACGGQVRPGVVWFGEALPEAALREAFAAACECDLLLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVRTRHPREHCLVGPAGEVLPELLRRAFPG
58
H2XXZ7
1.2.1.12
ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1"
MVLKIGINGFGRIGRLVTRAAAGRDDVEVVSINDPFIDLTYMVYMFKYDSTHGVFNGTVSEEGGKLIINGKPVAVNGERDPSKIPWAKDGAEIVVESTGVFTTIEKASAHLTGGAKHVVISAPSADAPMFVMGVNEEKYCNSMKVVSNASCTTNCLAPIAKVVDDNFGIVEGLMTTVHSYTATQKTVDGPSGKSWRDGRGAAQNIIPASTGAAKAVGKVIPQLNGKLTGMAFRVPTPNVSVVDLTVRLEKPASYDAIKTAMKTASEGKMKGILGYTEDKVVSTDFNGDKRSSIFDAGAGIALNDNFVKLVSWYDNEFGYS...
22
D8T629
1.1.1.8
ACT_SITE 248; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1"
MAPPGLEVASSSPEIQKITPLDAAAAVVEDDGTSASSESIATAARDRVAVIGSGNWGSVAAKLIASNTCCSDLFDDEVRMWVYEETLPSGEKLSQVINREKENVKYLPGVKLGSNVVAVPDLLNAVADATMLVFVTPHQFIEGICNTLKGNIRQNAIAISLIKGMEVKKDGPCMISNLITELLGIDCAVLMGANIANEVAVEKFSEATVGFRHDKRAADKWVRIFRRPYFLVTPVQDVEGVELCGTLKNVVAVAAGLVDGLDMGNNTKAAIMRIGLKEMRFFSKLLFPSVRDTTFFESCGVADLITTCLGGRNRRVADAF...
7
Q0UJ42
3.1.1.5
ACT_SITE 1242; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1360; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
MAAPDAMTSLVKSSVALLSSAHESLPTSLAAMKTAETAPSSTFGILGRVILSILSVLPTLLFWVSYTLPTWLFTLFSMSLTFTMNFTTLMLVLVFVVSTISYFVRYRYLTMYARLPPEPQREEPQVEVFPESQEGDSKRGLSNYLDEFLSAIKVFGYLERPVFHELTRTMQTRRLAAGETILLEEEKGFCLVVDGLVQIFVKSNREESDSDEDDGELQGESGGGSAQAHRQGYQLLTEVKNGAPMSSLFSILSLFTEDVKLRHDEDSGPSSSTPMSPQHRPSMTRNSSFNMDDSRPETPIEAQEATIRRRRTSALASPTA...
131
Q54N38
3.4.19.12
ACT_SITE 83; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393"; ACT_SITE 157; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393"
MSENEGWCTIESDPGVFTELITKIGVKDIQVEELYTLDSSEYDRLKPVLGLIFLFKWEKEEENRTISDNENIFFANQVIQNACATQAILSVLLNSEGIELGEELSNFKSFVGDFPPMMKGEAIGNSELIKETHNSFTVQDPFIFSKKKNRKPSDAFHFISFIPFQGKVYELDGLKKGPYCLGDCTPDNWLEIATPFIQKRMEKYSQGEIRFNLMAVIKNRQTTLQEKILTLEKKKNDLEIKLSELNSGSGGDNKEESGGATPTTKEDLNFMINVVNNDIEEANNEILMEQEKFRNWKDENIRRKHNFTPLILNLIKGLAE...
175
A0A9J7NBP1
3.2.1.35
ACT_SITE 139; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
MLIIYYGMTPSSTTTVFVILSLVQAHVSVGGPALPDRPFNIVWNVPSKVCMKKFGIEINLDGYEIVYTPGHEWNGTYMTIFYARDLGLYPSIHEHTWEETNGGLPQKADLQAHLARATDDISRLIPDADYRGVGVIDWEFWRPLWRRNWGSKKIYCTKSEELVRQKLPYASTAEVTSKAKDEFEGAARMWMGETLNLVKTFRAGGLWGFYLFPDCYNFPYKIRLQEDPSYDCLKKVKSDNDELQWLWEGSTALYPSIYLSNVFKTLPGSEQYIRARVAETFRVMDARQSSDIPVYPYVRLRYRESLEYLTKVSFILLSLI...
166
A2VD90
2.3.1.286
ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSVNYAAGLSPYADKGCCGLPEEFDPPDELRRKVEELAKMIRESSYVVFHTGAGISTSCGIPDFRGPNGVWTLEEKGLDPKFDSTFESACPSPTHMALLQLQRVGVLKFLISQNVDGLHVRSGFPREQLAELHGNMFVEKCSKCGKQYVRDQVVGTMGLKPTGRHCDVPKVRGLRACSGKLKDTILDWEDSLPDTDLNLANEACRKADLSITLGTSLQIRPSGNLPLLTKRKGGKLVIVNLQPTKHDKHADLRIHGYVDEVMTQLVELLNEKIPVWTGIQTKTESSYRNHKVEDNSYNNSVVDSKLNQKRDRCKEEPNLE...
58
A0A059CAH1
1.11.1.7
ACT_SITE 110; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSCKLHADPVRCLLILLNLDPVVKTLRLGDNNHRSSWHKAMACSKLFLSCLLVQLTLLFLVPEVAHGQGLKVGFYQKACPNAEAIVKGVIHEVMSVAPSLSGPLLRMHFHDCFVRGCEGSVLLNSPTNQSEKNAGPNLSLRGFQTIDRVKTALEKACPGIVSCADILALVARDVVVATGALSYDVETGRRDGNVSILTDALNNLIPPTANITTLKADFAKKGLSVKDLVALSGGHTIGTSHCSSFSDRVYNFTGKGDADPTLDSNYIARLKLRCKPNDQTTLVEMDPGSVRTFDVKYFDLIPKRRGLFTSDSALLDDSET...
14
A0A803T9A5
2.7.10.2
ACT_SITE 514; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000604-1"
MANAHSISHLPYFFGNITREEAEDYLIQCGLSNGLYLLRQSRNYLGGFALSLVHDSKVYHYTIEREISGSYAISGGKSHRSPVELINYHSDEVDGLVCLLKKSCNRPPGVEPKTSQFEDLKENLIREYVKRTWNLQGHALEQAIISQKPQLEKLIATTAHLKMPWFHGMISREESEQRVHLGTKTNGKFLIRERDNNGSFALCLLNEGKVLHYRIDKDKKGKLSIPDGKKFDTLCQLVEHYSYKADGLLRIITDPVPNPNFHLTNGQSDFGNTPELPKRSTNKTWSTGGIINRIKSYTFPRPGSQKVNDERMLKMSSFCS...
98
A0A0K9PJE8
1.11.1.7
ACT_SITE 75; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MESRGSRNGDLIMGFVVVFAVLLMGSTGSVTASDLKIDFYAQTCPAAEVLIKYITYVNVLENPSLSAKLLRMHFHDCFVEGCDASVLLDPVDNSTTATQVEKQARPNLTLGGFDFIDQAKQLLETVCPRIVSCADIVALATRDAISYKFGREMWQVPTGRRDGKVSLASNAIANLPPPFFNLTALRQSFSDKGLNLIDLVALSGGHTIGVSHCKTFLNRLYNFGGTGKADPTLEPSYADVLKKSCPATTTDNNKTVEMDPSSSFSFDTHYFTTVLKKKGLFTSDAVLLDDPAAVAAIERFRDSDNFYKQFGKSMEKMGGI...
14
B9RXP7
3.2.1.21
ACT_SITE 411; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
MEFWLVYYIFLLFEVWLSIFMISCHSISLNASPFPSSFLFGTASSSYQFEGAYLSDGKGLNNWDNFTHEPGNILDGTNGDISADHYHRYLEDMNLMEDIGVNSYRFSISWARVLPKGRFGHINQAGIHHYNKFIDALLRKGIQPFVSLTHFDIPQELADRYGSWLSPEVLEDFKYYADVCFRSFGNRVKYWTTFNEPNVAVIRGYRSGIFPPAHCSGSFGNCSSGDSDREPFIAAHNMILSHAAAVDVYRTKYQKEQGGCIGIVMNAIWYEPISNSLEDKLAVERAQAFYLYWFLDPIILGKYPSEMHEILGVDLPAFSN...
161
A0A1B6QFT1
1.11.1.7
ACT_SITE 122; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MLCCYSSLTAVTAAAVAEKMARLGVIVLVALLAAAAAQAQGSYGSGYAVPALSLESAPVPPPISSPPPAQTPPPPASARPKLRFDFYKRSCPYAEEIVREAVRNATNVNPGLGAGLIRMAFHDCFVQGCDGSVLLDPTPANPRPEKLSPANFPSLRGFDVVDAAKAALEKACPGVVSCADVVQFAARDAAFFLSGSKVYYSLPGGRFDGRVSFENETFTFLPPPSFNLSELIQNFKVKGLNVDDLVVLSGAHTIGLSHCSSFLSISTPPSDMNPGLATVLKKQCPAKPNFTNDPTVVQDVVTPDKLDNQYYRNVLHHKVL...
14
D8RPM5
1.1.1.100
ACT_SITE 220; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1"
MASASLISGFATTTPAAAPALQSRQHLRFGRNLQLCSSLSVRSSCSSSAIRAQVATATEPSHEPTKLVEAPVSVVTGASRGIGKAIALALGAAGGKVLVNYARSSKEAEDVASQIEELGGSALVYGGDVSKEEDVEALFKAVIDKWGTIDILVNNAGITRDTLLMRMKKSQWDEVINLNLSGVFLCTQAATKVMMKKKKGRIINISSVVGVTGNAGQANYSAAKAGVIGFTKTVAREYAGRSITANAIAPGFIASDMTAKLGDEIEKKILQTIPLGRYGQPEEVAGLVKFLALDPAAAYITGQVFNIDGGMVM
2
Q9FM99
4.2.1.1
ACT_SITE 204; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01134"
MKISSLGWVLVLIFISITIVSSAPAPKPPKPKPAPAPTPPKPKPTPAPTPPKPKPKPAPTPPKPKPAPAPTPPKPKPAPAPTPPKPKPKPAPTPPNPKPTPAPTPPKPKPAPAPAPTPAPKPKPAPKPAPGGEVEDETEFSYETKGNKGPAKWGTLDAEWKMCGIGKMQSPIDLRDKNVVVSNKFGLLRSQYLPSNTTIKNRGHDIMLKFKGGNKGIGVTIRGTRYQLQQLHWHSPSEHTINGKRFALEEHLVHESKDKRYAVVAFLYNLGASDPFLFSLEKQLKKITDTHASEEHVGIIDPKKLSFESKHYYRYSGSLT...
199
A0A059BA15
1.11.1.7
ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MDLELSRVLALLAYCCLMGTGNAQLRFGFYGQTCPSAEPIVRSVVRNAVISNPNMAAILLRLHFHDCFVEGCDGSILIENGRSAERNAFGHQGVGGFEVIEEAKKHLEVTCPGVVSCADIVALAARDAVAMANGPDYEVPTGRRDGRVSNVSLAEDMPDVGNSIQQLKSKFFQKGLTEKDLVLLSAAHTIGTTACFFMTDRLYNFMPGGGSDPSINPDFLPELKSMCPQNGDVNVRMPIDHGSEQTFDDQILRNIRSGWAILESDAKLNDDPVTRSVIESYVGLFNPIFGPSFEAEFVESMVKMGQIGVKTRVKWRDQAG...
14
A0A3B5Z2F1
1.11.1.7
ACT_SITE 124; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MRIEPAAPEDSPPHAGVGTLRRYISPGRQSSSSSSSSFPCLISHLAIVVSCIAKERGEKMASRAATMVALLLAAVAATCARAQLHEKFYSESCPSVEDVVRREMVRALSLAPSLAGPLLRMHFHDCFVRGCDGSVLLDSANKTAEKDAQPNQTLRGFGFVERVKAAVEKACPDTVSCADVLALIARDAVWLSKGPFWTVPLGRRDGSVSISNETDALPPPTANFTVLTQLFAAVNLDAKDLVVLSAGHTIGTSHCFSFSDRLYNFTGMENPSDIDPTLEPQYMMRLKSKCASLNDNTTLVEMDPGSFKTFDTDYFKLVSK...
14
A0A2C9VSE4
3.1.1.11
ACT_SITE 490; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQHLRSLLLVCMLLLLASVCKANEVANTIFVDKSGKGNFTTIQNAIDSIPQNNTQWIRIQISAEKYSEKVVIPANKPFIFLEGAGRNNTSIEYGDGQDLPTSATFISYADNVVAKGITIKNTYNLQNKGQNISIKRATAFSVQGDKSAFYDCAFIGIQDTLLDDEGSHYFKNCYIEGATDFIYGSAQSIYEECVISFNVGKYKPGSTGSMTAQMKVEPEDPSGFVFKNCEITGTGKAYLGRAWGPYSTVIVYNSTISDVILPQGWNAWHFVGHEENFTYVEADNTGAGADTSHRVPWLKKFDASQLTKYINLSYIDTDAI...
125
F7GD18
1.11.1.24
ACT_SITE 51; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MASGNAHIGKPAPDFHATAVENGAFKEVKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSENASAFRQLNCEVLGVSVDSQFTHLAWINTPRNTGGLGTMNIPLLADLTHSIATDYGVLKEDEGIAYRGLFIIDNKGIVRQITINDLPVGRSVEEILRLVQAFQYTDKHGEVCPAGWKPGSDTIKPNVKDSKEYFSKNN
12
Q8ZYN0
2.1.1.77
ACT_SITE 56; /evidence="ECO:0000255|HAMAP-Rule:MF_00090"
MAKRLVEELERDGIVKSERVKRALLTVPREEFVLPEYRMMAYEDRPLPLFAGATISAPHMVAMMCELIEPRPGMKILEVGTGSGYHAAVCAEAIEKKGRIYTIEIVKELAVFAAQNLERLGYWGVVEVYHGDGKKGLEKHAPFDAIIVTAAADVIPPALIRQLKDGGVMVIPVEERLGQVLYKVVKRGDKIEKKAITYVMFVPLR
49
Q9KPZ5
3.2.1.52
ACT_SITE 537; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
MLKKSLISIAVFTSLSGCALNTTSPQEVVDTLANNLDVQYQVVNNHGADTGLACQTLEAEWASCNQVNMTLVNRGEAVNSKDWAIYFHSIRLILDVGNDQFKITRVTGDLHKLEPTDKFDGFAAGETVTLPLIGEYWTLFETDFMPRAFVTAPDAEPKVIAALNTEDVASFVSGLEGENLKRTPSDNNVFAQALSRFEKNSDVALQDVTHALIPTPLQVKSHSGSVSIAKGIALPSKAFDGEQMQALNERAQLLGVNLKGVMPAQVIINPKSFKGDLAKSGAYRLAITDKAVKVTAFDQAGAFYAMQSLLGLVDMADATQ...
170
Q9X909
5.6.2.1
ACT_SITE 334; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383"
MSPTSETAKGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGAAEVPEKYTGEVRRLGVDVEHDFQPIYVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAWHLQEVLKPKIPVKRMVFHEITKDAIRAAVANPRELNQKLVDAQETRRILDRLYGYEVSPVLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPSSLVARLQTVDGRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVRSVESKPYRRSPYAPFRTTTLQQEASRKLGFGAKSTM...
221
Q0AEP6
1.3.3.3
ACT_SITE 104; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333"
MDFAQVKDYLVNLQNNIVAGLEQADGGSFRRDSWDRPEGGGGTSCVIEEGNVLERGGVNFSHVHGKGLPASATAARPELAGRAFEAAGVSLVLHPRNPYAPTVHMNVRFFAAIKEGAEPVWWFGGGMDLTPYYGFEEDAIHFHQICKHALQPSGSEYYPRFKKWCDEYFYLKHRKEPRGIGGVFFDDLNQPDFVTCFNLTKSVGDQFLAAYVPILQKRCNLPYGERERDFQAYRRGRYVEFNLVWDRGTLFGLQSGGRTESILMSLPPIVKWRYDWSPAAGSPEAKLYTDFLIGKDWLPLD
27
B7Q2N6
3.1.4.11
ACT_SITE 329; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 374; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"
IVDGRFRVDCAESATIEDVLQYLSRGMKLHKVRSSKKYYKRRYQLNLDNMLLVYAQSRKPFICSKKTYLDIFDVEEVRKGWKTDVFNDVESKFRRRKSYLPFGSLNMNEDTCFSIVISPKNDTLDLVACNANDCELWVRGLRHLVANCKNTRRDQEYERWLRDQFQKADVNRSGSLNFSECQNLLKQLNVSMDKNHCRALFNCHKVDGEDVLDREEFIKFYHSLLSRPDIDKIFKTYTAQNMTIMGPEELRRFLTQEQKVLVTAEVLFADLSICRVGPVPSGRIGSGRIGSGFRDMLLSDDHNIFDKEHNHVCQDMSQPL...
153
P54666
2.7.11.22
ACT_SITE 145; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTMLGALTGRQLSSGLKDQFDRYNRMDILGEGTYGVVYRAVDRATGQIVALKKVRLDRTDEGIPQTALREVSILQEIHHPNIVNLLDVICADGKLYLIFEYVDHDLKKALEKRGGAFTGTTLKKIIYQLLEGLSFCHRHRIVHRDLKPANILVTTDNSVKIADFGLARAFQIPMHTYTHEVVTLWYRAPEILLGEKHYTPAVDMWSIGCIFAELARGKVLFRGDSEIGQLFEIFQVLGTPMDAEGSWLGVSSLPDYRDVFPKWSGKPLTQVLPTLDGDAVDLLSQMLRYNPAERISAKAALQHPWFSDAMF
102
Q757X8
2.7.11.1
ACT_SITE 521; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MPQQVRLSRENSVKRSRSLTKSFRGLFKFNSPGSPPSSAATSDSSEMSGAQGGRGNGLLGGRTKKASISPKSEAQFTQRNKSAESVVSDEGVAMVASAGAQFYGRGKHESSPNVLMTGGEEAARAAGRASAESIALSEGGPPSIDTKLERVTPSLIYPQNGRAKHSSQRSRSASVGRNKERGGPTPAPIGSIREEESKKAHKCIIQQEHFTVDENGNHQHSLKVLPLIVQDPESHKPKLFSFSAVFKSHKNGEDEELSDAFSILPDYSTVLEKTLVEPLSEVKIFSEAAQPDENGGRTEANQPKDMPKIVNKHAAIGNEE...
99
Q4V8A3
2.7.12.1
ACT_SITE 334; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MGGAARERGRKDAALPGAGLPPQQRRLGDGVYDTFMMIDETKCPPYTNTLCNPSEAPVSRRLNITTEPFTRGHTQHFVSGGVMKVEQLFQEFGSRRTSTLQSDGVSNSEKSSPASQGKSSDSLGTVKCSLSSRPSKVLPLTPEQALKQYKHHLTAYEKLEIISYPEIYFVGPNAKKRQGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQ...
107
O25367
3.1.3.3
ACT_SITE 8; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 10; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MQKLAVFDFDSTLVNAETIESLARAWGVFDEVKTITLKAMNGETDFHKSLILRVSKLKNMPLKLAKEVCESLPLFEGALELVSALKEKNYKVVCFSGGFDLATNHYRDLLHLDAAFSNTLIVENDALNGLVTGHMMFSHSKGEMLLVLQRLLNISKTNTLVVGDGANDLSMFKHAHIKIAFNAKEVLKQHATHCINEPDLALIKPLI
147
Q92207
2.7.11.24
ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSADGEFTRTQIFGTVFEITNRYTELNPVGMGAFGLVCSAVDRLTGQNVAVKKVMKPFSTSVLAKRTYRELKLLKHLKHENLITLDDIFISPLEDIYFVNELQGTDLHRLLNSRPLEKQFIQYFTYQIMRGLKYIHSAGVIHRDLKPSNILINENCDLKICDFGLARLQDPQMTGYVSTRYYRAPEIMLTWQKYDTEVDLWSVGCILAEMIEGKPLFPGKDHVHQFSIITELLGSPPADVIDTICSENTLRFVQSLPHRDPIPFSERFASCTHVEPEAIDLLAKLLVFDPKKRISAVEGLTHPYMEAYHDPTDEPVCESK...
104
A0A803SZ80
2.7.10.1
ACT_SITE 837; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MGAWLVRPWLRPALLVAARGGQEKAERRRRRKKRRKKRLWWVQRDRGWWSSAGPTAGSGPGPCPCGGKKPANLDGAQGVSERARMLGVRLPLPWALLWPLLLLPGGALRSGLGSAAGSQVNLLDSRSVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCRVMEQSQNNWLLTNWISNSGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFETDDEDGRNVKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLTKKGFYLAFQDVGACIALVSVRVYYKKCPVVVRNLAIFPDTITGADSSQLLEVLGS...
97
A0A0R0EXJ4
2.3.1.286
ACT_SITE 134; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSLGYAEKLSYIEDVGNVGMVEYFDPSHVLREKVDQLAIMIKKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKALPEASLPFHRAAPSMTHMALVELEKAGILKFVISQNVDGLHLRSGIPREKLAELHGNSFMETCPSCGEEYFRDFEVETIGLKETSRRCSVAKCGTRLKDTVLDWEDALPTKEMNPAEKHCKQADIVLCLGTSLQITPACNLPLKALRGGGKVVIVNLQKTPKDKKASLVIHGFVDKVIAGVMDQLNMQISPFVRIDLFQIILVQALSNDKRYVNWTLQVASAHGQKAALPFIKSVEISFLD...
58
A0A9R0JE13
1.11.1.7
ACT_SITE 100; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASKVLFLLLVLAICSTFVFCNAGGSKKKSHYKHKGGWGHGHGHGPRGHDSYEPEYDGGLKNDFYRKSCPRAEEIVQTVTSRHVTSNPNLPAKLIRVLFHDCFVRGCDASVLLNSTGNSTSEKDANTNRNLEGFNVIDDIKSEIEKECKGIVSCADILTLATRDAVSLQYGRPLWKVPTGRRDGTISIASEASANIPSGASNFTVLVNNFASKNLTVRDLVALSGAHTIGVGHCNFVSRRLFNFTGRGDQDPSLNPKYADFLRTQCRDPADRTTTVEMDPGSSLSFDNHYFKILKEHKGLFVSDAALLTDDKAREFALQL...
14
K3Y9T8
3.2.1.14
ACT_SITE 92; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
MASSATSRILALGLALLCAAGLAAAQNVASVVTDSFFNGIKNQAPSSCEGKNFYTRSAFLNAVKSHPGFAHGGSQTQGKREIAAFFAHVTHETSNLCYISEINKSNIYCDRDPKYKQWPCVSGKKYYGRGPLQLSWNYNYGPAGKSIGFDGLRNPDKVAQDPVVAFKAALWYWMNNVHRVMPQGFGATTRAINGDLECNGKNTAQMNARVRYYKQYCKQFAVDPGNNLTC
158
K7MNB4
1.11.1.7
ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MEKGAMVFPFPIAVSCLFIIVHIFANSVSGSLVFNFYAASCPTAELIVRNTVSSSSSSDPSIPGKLLRLVFHDCFVEGCDASLMLLGNNTEKSDPANRSVGGFSVIESAKRVLEFLCPGTVSCADIIALAARDAVEIVGGPMIEIPTGRRDGMVSVASNVRPNILDTSFTMDEMINRFSSKGLSLFDLVILSGAHTIGAAHCSSFRDRFQEDSKGKLTLIDKTLDNTYADELMKECPLSASPSVTVNNDPETSMVFDNQYYRNLLTNKGLFQSDSALLSDNRTRKFVEDLANDQEFFFESWGQSFLKLTSIGVKTGDEGE...
14
E3K0K6
3.1.1.11
ACT_SITE 188; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MVSHKQVRQNLFIAAFFSLSAWAQSSPPTGALIVRQGSSTGRGEFSTISAAVAALARLTGPQTIFIYPGTYTEKVKITYPYSLSVQGYSANPTSTASNQVTVNAAVSAAQAGSNSNSATIWAHSSGIRISNLNIINSFGTGRDTQALALASTGNRQVFKYCAFSSFQDTVEIEGTAYFYGSHIEGAVDFIFGPGSAWFESVVLGVKASPTPVITAQRNSPGGGTAFVFNHAQIVSAGAKPGSAYLGRPWSPDASVVYQFCSLSNVINPQGWKIWSPSQPNTDRVNFQEFQNVGPGASTSARQIGTQRSAQVNIASILGSD...
125
Q8L7J2
3.2.1.21
ACT_SITE 211; /note="Proton donor"; /evidence="ECO:0000269|PubMed:23811195"; ACT_SITE 427; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:23811195"
MGRIKSSSGRCSTARLEAVAVLVVVFGVASSSLRGCIAQQSGGGLTRGSFPEGFVFGTASAAYQYEGAVKEDGRGQTIWDTFAHTFGKITDFSNADVAVDQYHRFEEDIQLMADMGMDAYRFSIAWSRIYPNGVGQVNQAGIDHYNKLIDALLAKGIQPYVTLYHWDLPQALEDKYKGWLDRQIVDDFAAYAETCFREFGDRVKHWITLNEPHTVAIQGYDAGLQAPGRCSVLLHLYCKAGNSGTEPYVVAHHFILAHAAAASIYRTKYKATQNGQLGIAFDVMWFEPMSNTTIDIEAAKRAQEFQLGWFADPFFFGDYP...
161
F6HGK3
2.1.1.37
ACT_SITE 1216; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016"
MGSAALLDSKGMKKNKAKLKSVAPSTKKTAAIGQKGKKRNVSQSSEQPVGSRKMPKRAAACTDFKERSVRISEISATIETKRDQLVYEEVVAVHLTSEQHEDHPNRRLTDFILHDSDGQPQPFEMSEVDDLLISGLILPLEESSDKEKQKGVRCEGFGRIESWAISGYEDGSPVIWVSTDVADYDCVKPASSYKNFYDHFFEKARACVEVFRKLSKSSGGNPDLSLDELLASVVRSMSASRCFSGGGSIKDFIISQGEFIYNQLIGLEATSNQSDQIFAELPVLVALRDEGCKRGDFMKAKGGSSGGSSMSGLRIRDIGN...
47
Q2G0R9
3.1.1.29
ACT_SITE 19; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083"
MKCIVGLGNIGKRFELTRHNIGFEVVDYILEKNNFSLDKQKFKGAYTIERMNGDKVLFIEPMTMMNLSGEAVAPIMDYYNVNPEDLIVLYDDLDLEQGQVRLRQKGSAGGHNGMKSIIKMLGTDQFKRIRIGVGRPTNGMTVPDYVLQRFSNDEMVTMEKVIEHAARAIEKFVETSRFDHVMNEFNGEVK
127
O13147
2.7.10.1
ACT_SITE 312; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
PLLVLDLIIQERGESFSHTVTAQHTSAKVEGLKAGTVYSVQVRARTVAGYGRYSNPVDFSTSLYVCPVSSSSTSMHLRRREELTTTTTGLKSREERFQKSDDPERSVQDLLPLIVGSASAGFVVILAMIVIAVVCLRRQRTGSELEYTEKLQQYVSPGVKVYIDPFTYEDPNEAVHEFAREIDISCVKIEEVIGAGEFGEVCRGRLKQAGRKETTVAIKTLKAGYTEHQRRDFLSEASIMGQFDHPNVIHLEGVLTRSCPVLIVTEFMENGALDSFLRLNDGRFTVTQLVGMLRGIAAGMKYLSDMNYVHRDLAARNVLV...
97
A0A2R6W0W2
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MTSSSLIKCVLLSIGAILLVTSSVDAQLSTTFYASKCPNVTAKVADVIKGWIKSDRQMGPALLRLYFHDCFVRGCDASVLLDGSQSEKQAAGNLNSLRGFNIIDDVKAKVEAMCPGVVSCADILALSAKEAMAAFGGITWTVTLGRRDGIVSSVTEGNSDLPPPFANFTQLVSMFAKKGLTMKDMVILSGAHTVGLTRCATMQSRLYSFSSLTPTDPTIEPSFATTLKKQCKQGDQNTIIKMDQSKTTDTWDFNFYSNVIKGKVVFQSDQALRTDSAAFQIVQAQNKAGGPFNSEFQAAMLKLGNIGVLTGNQGQIRKKC...
14
E9G6Y5
3.4.19.12
ACT_SITE 71; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 74; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 251; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"
MEMVPETEIQDEGILKQQREIEKEVAEIHPLVGNKQPLTCLLKEYMDDPIYTNKLTKLAGVYQSIRRVRPDGNCFFRGFGFSYFERLLDNEEEWKKFQAIVMGTKDQLISQGFPKFTLEDFFDSFMEVVNRLGGEGKMDAEELSRIFNEAGTSDYLVVYLRLVTSGQLQKEEDFYQNFLEGGKSMREFCQQEVEPMYRESDHMHAIALGSALKVGIRVVYLDRGEITTSPPEHDFPEDCTPSVYLLYRPGHYDILYK
175
A0A6I8N549
2.7.11.1
ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1"
MDPRHCAALQISTRDPQEDFELLQRVGGGTYGEVFKVTGPSPILPALPPTPGCVSPTDDDVSTLQQEILIIRNCKHPNIVAYHGSYLRFNKLWICMEFCGAGSLQDIYHVTGPLSELQIAYVCREVLQGLAYLHSQGKIHRDIKVKATGAGPVLWEGADFGISAQISATFARRLSFIGTPYWMAPEVAAVALKGGYTELCDIWSVGITAIELAERQPPMFDVHPLRVLFLMTKSGYQPPKLKEKARWSAAFHNFVKVALTKNPKKRPCATKMLSHQMVAQPRLNRSLTLELLERLRDPGKHRAGPGGAEPEEEEPEVRGR...
99
D8T1M6
5.1.3.3
ACT_SITE 210; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 343; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MLLLPAVAALTALATNPGAENEAVTVEAWGRGGALLYTLTAGTTTLRITDWGATITSLTMLDPRTGKRKDVDIVLGLDSLEPYMVSPGKTCKDGTSPYFGAIVGRVANRIKDARFTLNGTTYFLTGNDHNNTLHGGFIGYNNILWRSRVASKDPSSPSVEFLLYSYNTEQGFPGDIDVTVTYTLSGENELRVELIASTRNKMTPVNLAHHSYWNLAGHNSGSILNHTVKILASHYTPVDALLIPTGEIAPVAKTPFDFLEPMSIGSRIESVPGGYDHNFALDKTVRDDEGLYHAVTLEDPVSTRKMEIWTNQPGVQFYSG...
211
P9WHT9
3.4.25.1
ACT_SITE 58; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:20711362"
MTWPLPDRLSINSLSGTPAVDLSSFTDFLRRQAPELLPASISGGAPLAGGDAQLPHGTTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAAVAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLALPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSMKKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDADGAVDVPESRIAELARAIIESRSGADTFGSDGGEK
180
P0DOB6
2.7.1.11
ACT_SITE 127; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339"
MKRIAVLTSGGDAPGMNAAIRAVVRKAISEGIEVYGINHGYAGMVAGDIFPLTSASVGDKIGRGGTFLYSARYPEFAQVEGQLAGIEQLKKFGIEGVVVIGGDGSYHGAMRLTEHGFPAVGLPGTIDNDIVGTDFTIGFDTAVSTVVDALDKIRDTSSSHNRTFVVEVMGRNAGDIALNAGIAAGADDISIPELEFKFENVVNNINKGYEKGKNHHIIIVAEGVMTGEEFATKLKEAGYKGDLRVSVLGHIQRGGSPTARDRVLASRMGARAVELLRDGIGGVAVGIRNEELVESPILGTAEEGALFSLTTEGGIKVNNP...
84
A0A1L8EPW4
2.7.11.25
ACT_SITE 282; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50"
MHLNDIMASPHEPLNWSSSPNLIVDTIQEDKDYRVDYGDCTTIGHHEIKETPDKCDFLDNTNSPVNATVLNSISEDSRDQFENSVLQLRDQDEPENTAPQGSSHSGDGGNNSANEDIRIHFSRSRSGSGNGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRGEEVAIKKVREQKETDIKHLRKLKHPNIIAFKGVCTQAPCYCILMEYCAQGQLYEVLRAGRKVTPKLLVEWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHADTVKISDFGTSKELSDKSTKMSFAGTV...
105
A0A1B9ILM8
2.1.1.37
ACT_SITE 559; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MSSSDIIEIDDSDSELELIDMTSRSTSTSSSTRRSGDDDNKKRKRECVIEVISSDDDEDNEEIRTQLRELSVQEELVEAKEKQTETLRSSHRNTPSKRYRSHISINSSTCPPDHMQSHHPFRSQNATGYRPHLKSHLTWIVDTTDSPVERQSTYDVDGFEERCIKIYRKGFIHDDVEFIVDNAIVLPHRPPLYALIRSIFTLKFDDVSIKDKHFAHVHYIKSPNPHTDSSGRDGELFLRNAQCQDISIKQILKGQKLDFELIGGIKGKRRGSSKYFCQFVDQPSLSTIREPVFQDGFDRCDSCASRHQKHKFDDPRVLGD...
47
D6WT45
3.4.25.1
ACT_SITE 25; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1"
MPPVTSDYGMNAESDWMNAAHSTGTSIMAAEFNGGVIIGADSRTTTGAYIANRVTDKLTKVTDHIYCCRSGSAADTQAIADIVAYHLSFHGMELGEEPLVETGAAVFRELCYNYRDSLMAGILVAGWDKRKGGQVYSIPIGGMCVRQQVSIGGSGSSYVYGYVDANYKPNMSKEECVKFITNTLALAMSRDGSSGGVVRLGIITEEGIERRVVLGDQLPKFFEG
180
T1FZ44
1.11.1.24
ACT_SITE 52; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MSVQCGLKLAGPAPQFSGTAVVDGQFKQISLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDRVSEFKAIGAEVIACSIDSQFTHLAWIQTDRKKGGLGGLNIPLLSDLNRNISKAYCVYNEESGVDFRGLFIIDGHQNLRQITVNDLPVGRSVDETLRLVQAFQFVEKHGEVCPANWKPGAATIKPDPMKSKEYFEKV
12
Q8C042
4.2.1.11
ACT_SITE 497; /note="Proton acceptor"; /evidence="ECO:0000250"
MGDEDGGRRGGITRDLQKLKQQAMAYYQENDVPRKLEDLLNSTFYLQPADVYGHLKANYFSKLAKPPSICKIVGKTILDGLGLPTLQVEISCTIQNFPKYICAVAIPTHFEVVENALPEALDAEDSERAQAVNTAVQWINQSITEELWGLVPSNQAEVDHRLRTFFEHKVQEDKERKELEKSQEELVPAPPPVTLPPPPPPPPPPPSKKKGQKAGRRDTLLEKPVSPPEPPEPVLHGSMAIGAVSLAVAKASATLASDPLYLTLASLKHDQEQPSTFSMPLLMGSVLSCGKSSPGKLHLMKEVICIPSPGLTAKQSVELL...
200
A0A8I6A077
3.1.3.48
ACT_SITE 297; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 299; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"
MTPRKNFSGFLKTVCEDRRDLQSSHISVCKETAVLMEEEQDLPERPVKKAKMQEPGEQTLSQVNNPDTSDQKPETASLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLISTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDTENTALAATTYQTEKPGAMGPAPATQRLPSDSSTSPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKD...
149
E9HZC0
3.1.3.1
ACT_SITE 154; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
MVCSHKIIVLVVTLVLSSTAGVHGDEHHHSRPLRDSATDVNNKAEQSATEDAAYWTQLGQQLLFDELAKQRINSQAKNIIVFLGDGQYICAGPYSAAFKIQFYFGMSISTVTAARIYKGQKAGKTGEEEQLHFDRFPYAALSKTYCTDIQVADSACTATAYLCGIKIDVDTLGLDVNVIKKNCSTQIDPANQVDSVMTWAQLQLFIQSGSQQSDGYRDYDTNSNTCDDIAEQLVLSSPGKNLKVILGGAYLTPTTTTDPETQEACRRRDGKNLIDQWVTDHPTGKYVTTRDELVNLDMAGTDFLLGGRIDQAHHDGRAKL...
141
Q9RXP0
3.1.26.11
ACT_SITE 60; /note="Proton acceptor"; /evidence="ECO:0000255"
MLSAAVLGQPTRDNALWVTADSGKGQTRLLLDCGGHTLDTLPLHEVQATDHLLFSHLHMDHIAGFDDFFRVNFDRQSRENHLWGPPGAARILAHRLQGYWWNHAPQLRATWRIHEVDDAAVHTWRFELHEAFEIAHDEGRTPRTGPLIETPHLRVDAVPLQHQGPCLGYVLREPGRVNVDPAGLTRLDLTPGPWLAALKAGAEEVEIAGERRPAAPLRAELLREEAGDSLAYLTDFLLDEAELARLAPLLAGVRTLYLEAQYAPADADLAARNHHTTTEQGATLAARAGAQELVLLHLSRRYREADWREMLRAAQAIFPA...
137
A0A0K9P6R2
3.1.1.11
ACT_SITE 348; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSPQSMLLLFLIVFIYQTPSSISTQDFDFLITLGDAVDQLKDMITLVSSFSDLLWGGDKLSASAVADCLDLLDLSIDETTWAISATQEFSKRSAASASSIVRHQHDLRSWLSAVLSNQDTCNQGLSHINILLKTLIVQGMETVTSLISYGLSGIPGEYYGGEARGRNLMGVVENGYPGWVEEMDRRLLHRALGEYMNVDMVVAADGSGDFKTISSAVKSVPDKSEQRIVIYVKSGVYKENVYVHKDKWNIMLIGDGIGSTVITGDRNFVDGWTTYRSATFAVDGKKFMAKDITFENTAGPKKYQAVALRSNSDFSVFYRC...
125
E3KF66
2.1.1.33
ACT_SITE 265; /evidence="ECO:0000256|HAMAP-Rule:MF_03055"
MGANKKKRNFSAVDSSNQPNKKSTMTQSAADQAKEKLPHIMPRKRFYRQRAHANPFSDHNLDYPARSEEMDWSKHYPHFFQAPNSQTTIDHKEEGGEEEKNGVCTALADSSKKVVEFADVGCGFGGLLVAMAPLFPEKLMLGLEIRPHVCQYVEDKILALRAQQKIIQQQSSSTGEGTESVFELPSLPKSVPQNDKQIEQDADPVTNQASNEVTPDEELDDEAPIWVPKPGRFENVSVIRANAMKFSPNFFRKHQLSKMFFLFPDPHFKARKHKARIISPTLLSEYGYILRPNGIIYTITDVKDLNVWMVKHLSEHPLFK...
45
A2D8N0
3.5.1.98
ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MADEKKKRIVYFYDEDVGNFFYAPNHPMKPHRIRMAHNLILSYNLFPKLQIYRPKKATVEELTRFHTPEYIQFLQMATPDNTQNQACLFDKFNVGEDSPVFEGLFEFCQSSAGGSISAARHLNSGHADIAINWAGGLHHAKKGEASGFCYVADCVLGILELLERYDRVMYIDIDIHHGDGVEEAFYTTDRVLTVSFHKFGNEFFPGTGHDKDIGLGKGRHYAVNVPLKDGMDDKSYHYIFKPIIKHLIEWYRPQAIFLQCGADSLTGDRLGSFNLTIHGHGECVNYVKSFKLPMLVAGGGGYTVRNVSRCWTYETAVLLD...
184
A0A2A6C807
3.1.4.11
ACT_SITE 356; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 404; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MDANIICQFYLVLTVSVGGVTSRHGEGISGSIFDKYEDVGTLSTGSAQMDSPLIDLCSHTRVDEMGFYLYWHCDGKETQLIDLATVWEVRTGALPKDSRVLCEIERGGGSAGLPKDKGDAIEDRLVWISHGTDLVAPQHLFLLSDDPEVAKTWRQALSEIIRSARIKFVCPTTNLFKNWRRLCLATNERRKIPIKNIIRLFEAGKPEKMVQKCMTDLGLGGDKEREELDVELFTFDKFLRLYHKICPRTDVQELFVKLSGQKEYLTRERIVTFLNEEQRDPRLNEILFPFFDIPRVQQLIAKYETDDKYIQDGKMSGDAF...
153
Q8AAU2
5.1.3.3
ACT_SITE 190; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 329; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MNNTFPTEGNLSGLSRKDFQKEINNKETDLFILKNKKGMEVAVTNYGCAILAIMVPDKDGKYANVVLGHDSIDHVVNSPEPFLSTTIGRYGNRIAKGKFTLYGEEHELTINNGPNSLHGGPTGFHARVWDADQLAENIIQFNYVSADGEEGFPGNLEVEMVYRLEEEENALVIEYRATTDKATVVNLTNHGFFNLAGISNPTPTIENNIVTINANFYTPIDEVSIPTGEVAKVEGTPMDFTTPHTVGERINDKFQQLINGAGYDHCYVLNKIETGSLDLAATCFEPNSGRTMEVYTTEAGVQLYTGNWLNGFEGAHGATF...
211
A0A072UBK7
2.1.1.37
ACT_SITE 551; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MAGKRKTSSKTTTSGNAVTVDSVSGDTVTVTADSSSGNTVRKSRRLTKSSSSSADAVNVAADSATGETRSRSRKTTKSSNSNSSGDGTSVSADLTSGKAQKKSGKKTDLDKGKSVVASSGVKKEPKTESDPMNVDGGDNEVSSSKFLGDPIPIEAAKLRWPKRYQEKEKKKSRSRSNSDEEEVILARCHYTEAQVDEGVIYKLYDDAYVQGETDDYHFICKIVEMFEAVDGGLFFTAQWYYRANDTVIKQLGNLIEPKRVFFSEIQDDNPLDCLVKKLTILRLELKKDFDATKDIIPPCDYYCDTLYLLPYSTFLKLPSE...
47
A9UV35
3.5.1.98
ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1"
MSRPRVAYFFDADVGNFHYGPGHPMKPHRLALTHSLVLEYGLWSKMEIFRPYRASPEDMGRFHATDYINFLQRVTPDNYRTFGSYLQRFNVGDDCPVFDGIFDFCSIYAGASIEGAVKLNNKQCDVAINWSGGLHHAKKFEASGFCYVNDIVLAILELLKQHPRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGGHFFPGTGVMYELGAGRGRYYALNVPLKDGIDDMGYNELFKPVMREVISKFQPSAIVLQCGADSLGCDRLGCFNLSIAGHGNCVEFIKSFNLPLLVLGGGGYTIRNVARCWTHETGILLDEHL...
184
A0A9R0JEZ2
1.11.1.7
ACT_SITE 94; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MANKVLLLVFIIAICTTFVISDGKKKLHDDKDKDKGKGKGNGHGKDKHKNNGGLAINFYGENCPRAEEIVQTVTERHVSSNPDLPAKLLRVLFHDCFVRGCDGSVLLNSAKGSQSEKEASANRNLAGFEVVEDIKEEIEKECPDVVSCADILALATRDAVSLQYGRPLWEVPTGRRDGTTSLASEAEANLPSSFSKFPVLLNNFAIKGLSVRDLVALSGAHTIGVSRCNFVSSRLFNFTGKGDQDPSLNPSYADFLRTQCKGPSDATTTLELDPKSSLSFDNHYFQILKEHKGLFMSDAALLDDANARKITEEFLNSERF...
14
B9MT36
3.1.1.11
ACT_SITE 231; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MKRSFSSFALLLITLQAIQTIPTAISTTKLVPADISKVKAWVAKNINDFNDRKSNDSKGIPRIVLDELLASAEDRLRLIRVAKDGFADFTTISDALETIPKDNKRRTIIQIGGGEYWEKITIKCNKPFITFYGDPMDIPRIVFNGTASQYGTIYSATVAVESDYFMAVNVAFVNSAPLPNVNRTGGQAVSMRISGDKAAFHNCKFIGFQDTLCDDRGRHFFKDCYVRGTVDFIFGNGKSLYLNTTIDSVAEGTGVITAQAREHVTEDSGFTFIHCNLTGLGNNTYLGRAWKQRPRVVFAYTYMGHLINDEGWSTWKFPER...
125
A7MBL8
2.7.11.13
ACT_SITE 775; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAADSVQNDARGPMVSGRLDFDQNLDFSDTMVQKNLDEIKDQIKREIRKELKIKEGAENLRKVTTDKKSLAYVDNMLKKSNKKVEELHQELQELNAHIVVKDPEEVEEYPLTPDTPKSETRMSTNSNRLAALKKQADIELKVKQGAEDMIQMYSNGSSKDRKLLAAAQQMLQDSKTKIEFIRMQILKASQTSEINYENNDVTTSKPIISPLDLRIEELRHHYRIESAVADGAKNVMKLLGTGKVTEKKAHSEAQARLNESSQKLDLLKFSLEQRLSELPKNHPKGTLIMEELAMVASPPNSPRQSIMSTSNQYSTVAKPA...
100
A0A9R0IXM7
1.11.1.7
ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MTLKMPPHSSIFLVQLLAISCLSAQIEAQLKVGFYNQSCKSAERIVNEEVSKGFMTDKGVAPGLVRLHFHDCFVRGCDGSVLIDSTSSNTAEKDSPANNPSLRGFEIIDNAKTRLETECKGVVSCADILAFAARDSVAITGGPTYDVPGGRRDGRVSLASEVLRDIPAPSLNVDQLTQSFANKKLTQEEMVTLSGAHTIGRTHCTSINNRLYNFNRTNGGDPTLDSKYAGQLQQQCPQGSTDSSLVVPMNPNSPLVTDVGYYQDILANRGLFTSDQTLLTNNNTASEVNQNAGSQLLWMRKFAAAMVKMGQIDVVTGTTG...
14
P9WG43
5.3.1.1
ACT_SITE 100; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000305|PubMed:22120738, ECO:0000305|PubMed:25613812"; ACT_SITE 172; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147, ECO:0000305|PubMed:25613812"
MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAGGPLP
213
Q88YH3
4.2.1.11
ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 342; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"
MSIITDIYAREVLDSRGNPTVEVELYTESGAFGRGIVPSGASTGEHEAVELRDGDKSRFMGKGVTKAVDNVNKLIAKEIVGYDVTDQRAIDQAMIKLDGTPNKAKLGANAILGVSIAAARAAADELEMPLYNYLGGFNAHVLPTPMMNVINGGAHANNDVDFQEFMIMPVGASSVKEAIRMGSETFHNLKAILNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIERAGYKPGKDIAIAFDCAASEFYNEETGKYDLKGEGENGQSFTAEEFVDLLDSIVDKYPIVSIEDPLDENNWEDWQMATAKLGKKVQIVGDDLF...
200
Q7SB01
2.3.1.286
ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MAQGRQATKKSVDVLQAIPTKTHMALVELQERGILKGLISQNCDGLHRRSGIRADMISELHGNTNIEHCKNCGKEFLRDFYAVAPDNRPLHDHRTGRKCPICLTQPLHDTIIHFSEDLPLGPWSRAEAHCEKADLCLVLGSSLTVTPANELPQLVGERAAAQRKKQQTQQPDTDLVICNLQDTDLDYLCPSPDHRIYARADDLMERVMHYLSLPVPNFYVRRRLIVGTDVDPNPAGGRHVVTVKGVDEDNSTPASFLRTVKLVTAGGRPRIVKTEPFVLGWRGKIGEMEEEQNGSLAECRADEVRVKSETLTLGLEFMGN...
58
A0A251VGB2
1.11.1.7
ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAASCSTSLFLVFSSLLIFSSLLYVSEADYSAPITKGLSWDYHHKTCHKVEKIVRKHLKKVFDKDIGQAAGLLRLHFHDCFVQGCDGSVLLDGSHGGPSEQTAPPNQSLRKEAFDIIEDLRNLVHRECGRIVSCADIVALAARDAVHLSGGPDYDVPLGRKDGLSFATENATLANLPAPTSNATTILSALAVKNLTPTDVVALSGGHTIGVSHCSSFASRLYPTQDPTMEKTFAHGLKEVCPTNTTDATTAMDIYSPIKFDNKYFVDLMNRQGLFTSDQDLYTHKVTKPIVESFAHDEKLFFEAFVKAMIKMGQMEVLTG...
14
A0A1U8PR75
3.1.1.11
ACT_SITE 385; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MTTPHQPLLDRPKTSYTRILLLIFTLVAIICSATLVSVRSVRFSSSSTALPYRFCERAVDQKSCSVFLSEMASNTTLKMKDAGDVLQAFLEQSKVRMQNAMNVAKKFKHRINNPGEQAALADCMELMESSMDRIMDSMVAVDKQDATSYSNAHAWLSSVLTNHVTCLDGLEGSARTLMEPGLNDLISRARTSLAIFVSFSPRKTKLIDPLIDGFPSWVSSKDRKLLQSLPNEIKANVVVAKDGSGKYKTLGEAVAAAPDKSKTRYIIYVKKGTYKENVEIGKNKKNLMIVGDGMKSTIIIGSLNVIDGSTTFRSATVAAV...
125
Q7XSK0
3.2.1.21
ACT_SITE 194; /note="Proton donor"; /evidence="ECO:0000269|PubMed:33471829, ECO:0007744|PDB:7D6B"; ACT_SITE 408; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:33471829, ECO:0007744|PDB:7D6B"
MAGGSKTRIHASLVSTLLLLLPLASAIHRSDFPASFLFGTATSSYQIEGAYLEGNKSLSNWDVFTHLPGNIKDGSNGDIADDHYHRYEEDVELMNSLGVNAYRFSISWSRILPKGRFGGVNPAGIDFYNKLIDSILLKGIQPFVTLTHYDIPQELEDRYGAWLNAEIQSDFGHFADVCFGAFGDRVKYWTTFNEPNVAVRHGYMLGTYPPSRCSPPFGHCARGGDSHAEPYVAAHNVILSHATAIEIYKRKYQSKQRGMIGMVLYSTWYEPLRDVPEDRLATERALAFETPWFLDPLVYGDYPPEMRQILGGRLPSFSPE...
161
F4ITM1
2.3.2.31
ACT_SITE 334; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221"
MEEDDLNPAGKPLYRLYFKGLVTEEKEMLLAGFGVAICGDKDDLLFDLKVSIHDPTITLLEVELIALKSGLNQAVSLGINHISICCDHEYIFELVMGISTPKQESIALLLRDVQGIRKYLTSSIPVMLTQNQSNLAYDFAIEAISSEIIIDIPAQKETCNICLNDDINADQMFSVDKSGHMCCSECVKRHIEVRLLEGSLITCPHYRCNSLLTSVRCGNLLTPKLNKMWEQKTKDELIPVMDRVYCPNPRCSTLMSETELSGLNIGVRRCCVKCGEPFCVKCKVSWHNNLSCDEYKTLHPNPTENDGRLRDLANEKSWRQ...
67
Q55A55
2.7.11.1
ACT_SITE 722; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MARKIGSVRIEVLEGRNLVPMDSNGMSDPYGVVIVGDKKKKTKAIKHTLFPKWESDNCFEFDIDVNLLAITVEVYDWDRFSSDDRMGLTNIPVSQIQEYIVDTTKWYTLQPMKPNDKVSGEIKLKIRFDKDKTLPPPEKSPFIKAIKDNDTQAIELMMNKAKLDYTICDNEGTPAIHIAAASNNIPLITMLLKGSDARVSIRDQHGNTPLHLFVQKNVSLNCEDIINKLIERGCGINDENNLGETALHKACLATVVQKTTIVEQLLQKGAIINHQTKTRDTPLHYAIKVGKVEFVRFFLQNGANVMIEGGKPSRTPLELA...
99
E9HGX0
1.1.1.37
ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MAAVTKPQILKSVLNGAKQFSTSTKSHTKVAVMGASGGIGQPLSLLLKQSPLVSQLNLYDIVHTLGVAADLSHINSKAKVTGFVGPDQLKSSLEGCEVVIIPAGVPRKPGMTRDDLFNINASIVRDLAVACAEVCPKALIGIIANPVNSTVPIASEVFKKAGVYDPNRIFGITTLDIVRANTFIAELKGLDPTTVNCPVIGGHAGITIIPLISQCMPGVSFPTDQLKALTERIQEAGTEVVKAKAGAGSATLSMAMAGARFAVSLIRALRGEQGVVECAYVRSDLTESKYFSTPILLGANGIEKNLGLGNLSDYEKQLVT...
5
A0A2K3DBY2
2.3.1.286
ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
MSLGYADRLKPKKNLGGQLGAQEFHQDLDDIKKGVKELAGWVRDAKRVFVFTGAGISTACGIPDFRGPNGIWTLRKKGEALPTDFTPFEYARPSFTHMAISGLVAAGKCPYVCSQNVDSLHLWSGVPRSRIAELHGNCFAERCRGCGAEYARDFQMETVDFRPSGRRCTAPGCGGELVDNILDWDTPLPQDELDEAVRQAEEADVALVLGTSLQIQPANEIPVLTRDEGGKLVIVNLQKTPKDRRANLLLRARVDLAMALLARELGMQVPPYIRTETLVVEHEAAAAAVEATAGQGGLRGLTIHVSSRHGRACPLPMVES...
58
Q9LSR8
2.7.11.1
ACT_SITE 468; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MARWLLQILIISSLHLSSVSSQQETSFVYESFLDRQNLYLDKSAIVLPSGLLQLTNASEHQMGHAFHKKPIEFSSSGPLSFSTHFVCALVPKPGFEGGHGIVFVLSPSMDFTHAESTRYLGIFNASTNGSSSYHVLAVELDTIWNPDFKDIDHNHVGIDVNSPISVAIASASYYSDMKGSNESINLLSGNPIQVWVDYEGTLLNVSVAPLEVQKPTRPLLSHPINLTELFPNRSSLFAGFSAATGTAISDQYILWWSFSIDRGSLQRLDISKLPEVPHPRAPHKKVSTLIILLPVCLAILVLAVLAGLYFRRRRKYSEVS...
99