Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A2K2A8B4 | 3.1.1.11 | ACT_SITE 407; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTEANQYISISKKNKKLILAIFASFLLVATIIAVVTVVNSHKNSTQDDASHAKLETSCNSIKYPDLCSSSISTLSAAADTLKVPMNVFLGQINITIDAAQSNMVALSKKYSIPRFKKQKPALDDCWKNYDGVVTYLKKVFADVEVYTKRKPPQPQADQDLKTRLSSCSTSVNSCLDGFSHSKENNNARRQLFSGIIDVTVNCRKALEMIKSEPTADMAAGLKTTNRKLKEGNDSNEGGAEWLSVTDRRLFQLSSLTPDVVVAADGNGNYKTVSAAVAAAPKYSSKRYIIRIKAGVYRENVEVPKEKSNIMFLGDGRKTTI... | 125 |
A0A067GSF6 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGTKAVFLLLALLSFSAVSLRSALAENEEDPGLVMNFYKDTCPQAEDIIREQVKLLYKRHKNTAFSWLRNIFHDCAVQSCDASLLLDSTRKTLSEKEMDRSFGMRNFRYIENIKEAVERECPGVVSCADILVLSGRDGVVALGGPYIPLKTGRRDGRKSRAEILEQYLPDHNDSMSVVLERFAAIGIDAPGLVALLGLSYYYWSISSGSHSVGRTHCVKLVHRLYPEVDPALNPDHVPHMLHKCPDAIPDPKAVQYVRNDRGTPMVLDNNYYRNILDNKGLMMVDHQLATDKRTRPYVKKMAKSQDYFFKEFSRAITLLS... | 14 |
M5W9R1 | 3.5.4.5 | ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MDRPRFVIEASEAESMAKRSNLTVLQLLPSLVKPAQALARPPISKFHVGAIGYGSSGRIFFGGNLEFPGLPLHYSVHAEQFLVTNLSIHNESKLEYVAVSAAPCGHCRQFLQEIRGAPDIKILITSAESGDDNSGLNRFDPLLHLLPHRFGPEDLLGGDVPLLLEHHHNGLSFLGETEILTNDFKLNAELKVAALEAANKSYAPYSGCPSGVAILDCDGNVYKGSYMESAAYNPSMGPVQSALVAYIVGGGAGYEKIVGAVLVEKDGVLVKQEHTARLLLQAISPKLEFRVFHCASGSNACKKS | 187 |
A0A078CGE6 | 2.7.11.1 | ACT_SITE 144; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MARQMTSSQFHKSKTLDNKYMLGDEIGKGAYGRVYIGLDLENGDFVAIKQVSLENIVQEDLNTIMQEIDLLKNLNHKNIVKYLGSLKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVTVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLNEADVNTHSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDDSPPIPDSLSPDITDFLRQCFKKDSRQRPDAKTLLSHPWIRNSRRALQSSLRHSGTIRYMKGADSSSEKDGEGSQDIAESVSAEKV... | 99 |
W1NLC8 | 3.1.1.11 | ACT_SITE 426; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MMSNSTSFRGYGKLDETEQARLEARHKTRKRMTIISLSTIVLVTIVVAVTVGPTQSHAGKQKPDSSSDSRPYYSSIKALCNLAVYPDSCFSSLSPIANVNHLDPESLFKLSLEVALKEISNAASLPEKLTRKLNDTAIAPALEVCSQVLTDAVDQLNITITSVECNSRNLAGILSQENVDDLKSWLSAAITDVETCLEGFEDANQVLVSQIHESLRNSTEFTSNSLAILAGITNVLGSLNIPTHRRLLGHFSGDFPSWITSKDRRLLQSFDPRDAADFVVVKDGSGKYKNISAAIKAVPKQSKKRIVIYVKQGRYVENVV... | 125 |
C8VNK6 | 5.1.3.15 | ACT_SITE 184; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 290; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MDRSKKPAAIGVTATPPQPTISLANNVVQATLPSGESVTVNLNGATVTSWKSASGAEKLWLSEAAVLDGSKPIRGGIPVVFPVFGPPPSDHATSFLPQHGFARSSLWEFLGKSSSESSGANSGDDTVKLDFGLSSGLLSEDFKSKWPHEFGLVYSVTLSPEGLGTSLQVQNQGERSFEFQVLLHTYFAIDDISQIHVKNLQGKTYIDKVQNATTHTESNSSVQFTSETDRVYKDLDPSVPLVISLGDKELFSITREGLNDAVVWNPWIEKAKAMGDFSPDDGYKKMVCVEAGAVNGWQSLEAGESWEGGQFIKSK | 210 |
Q54WD7 | 2.7.11.1 | ACT_SITE 487; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNKYEVVKLIGVGGEAKALLVKRINSDKLYVMKQRMFFLLEEANEGLCEAMSLAKIQSPYIVRFEEVFLDNNSNMFSLCIVMEYCEGGDLMDNLFKRISDSFLKNSGLNNNQNNNNNNNNNLNSIVNNNILNNNKNSKQSTTNTNSSGSNSSIASNTTNNNNNNNNINNNNNLKAYENFFSKYVPSETLKGVNQLVEPNCNKDNNKPIEITTTDSPRIIINDNESTNNLNSQSDQILQFSISSESSSFSNNDLINSPNSNDSNLHQSSSNSSICGDYSSPPNLEKISSPGTSTPYQKGSNGNTVNIRCSDIVVEAVSPIK... | 99 |
A2ENW6 | 2.3.1.48 | ACT_SITE 283; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MSEVTKFKKNDVVSAYCEEYQTNMDAEIVDFRHHRQQAYVHFIKQDKRLDRWMDVSNLFPSTESNTNKQEEHVLSRNQRKLLDDSDSDDEATTAEFIQFEKVHREVTKIRNIDFITIGKFTIRTWYYAPYPPPFYKMDHIYICEHCFSYFKSPEDLQAHIDEKKELCPPGREIYREGNLSVFELKGKRQKLACQNLCLLSKLFLDHKTLFYDVEGFIFYVLCECDDSGAHIAAYFSRELNSAQNNILACITTLPPYQKRGYGHFLISLAYEIAKRQHRTGGPERPLSDLGKIAFKAYWRDTILNLLKNQSAEITSVDSLV... | 61 |
Q02779 | 2.7.11.25 | ACT_SITE 222; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKL... | 105 |
P42959 | 3.4.21.89 | ACT_SITE 46; /evidence="ECO:0000250"; ACT_SITE 88; /evidence="ECO:0000250" | MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEGSSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKNDQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNGMGMPSEDDIIGTESLVFYPFGEMRQAK | 178 |
I1M5B6 | 3.2.1.23 | ACT_SITE 223; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 306; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MRIGLKKKKTTSGAASKLLAMAKKLSSKPTILFIFVSFMLFCAFLPVFAPLPSFSSHHSHRNTVNRKFEIANDRFWKDGEPFQIIGGDVHYFRVHPEYWEDRLLKAKALGLNTIQTYVPWNLHEPAPGKLVFEGFANIEAFLNLCHKHGLLVMIRPGPYICGEWDWGGFPGWFYSMIPTPKPRSSDPTYLQLVERWWGNLLPKFVPLLYENGGPIIMVQIENEYGSYGDDKEYLHHLITLARGHLGHDVILYTTDGGTRETLEKGTIRGDTIFSAVDFGTGEDPWPIFKLQKEFNAPGKSPPLSAEFYTGWLTHWGEKNA... | 163 |
A0A804JSV0 | 2.3.2.26 | ACT_SITE 822; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MESSGSSPTAAAFPRFLSSQHHHERKNDDYADQDHSFPLLKMVKPWPPLSFYPLSFSPATVDDADEDLQFFVRLLTGESLVIHARPTDTVDSVIERIEKVTGIPCYQQRLIYRGRQLQGDSTLLDSAVKKDTTLQLTCGLRSTDQPTSWRVVSDLISSIWFLNTAAPGTHSSVRQWNTVDLLVKRFLANTLLDSDADKKKISARLHVFILAGAPSELVKLYLSPVLENRVIAAVAIRIFLTPDPDFLPAQMHLHCAPIVLTFCKMLAASVGRKDRLYIGCRSTLARLLKSGPPYYVHWTSVHLLTDLQVFIAELVGLADV... | 65 |
B3S6Y5 | 3.5.1.23 | ACT_SITE 171; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR017632-1" | MAENVCPSKRAQSRSTLHKKQGNSSIVKIAMMALLQRFYLLLVFLVVIVLAKDQVNGDVWESCETSAYPPDKKDKIEWYPVNLDSAPQERWMQLASKKKHELAGMIGVVKNFTRFFFKNLLVDWVDKDWGALADKIPKPYSDEIKGIAKAANIPLGEIVLYNIFYEIFSVCTSVVAQDKNGILVFHKGKIYHARNLDFGLFLGWDFKRDTWLLTEYLRPLVVNVDYQRNGKTVYKSVSFIGYVGVLTGIKPGVASVTINERFISDGGYIGLIEWVLGLNDAKFMSLLLRDTLDKASSYQDAVNVLVEPQLIAPAYFIVAG... | 182 |
Q9M2Z1 | 2.7.11.1 | ACT_SITE 816; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKLLLLLLLLLLLHISHSFTVAKPITELHALLSLKSSFTIDEHSPLLTSWNLSTTFCSWTGVTCDVSLRHVTSLDLSGLNLSGTLSSDVAHLPLLQNLSLAANQISGPIPPQISNLYELRHLNLSNNVFNGSFPDELSSGLVNLRVLDLYNNNLTGDLPVSLTNLTQLRHLHLGGNYFSGKIPATYGTWPVLEYLAVSGNELTGKIPPEIGNLTTLRELYIGYYNAFENGLPPEIGNLSELVRFDAANCGLTGEIPPEIGKLQKLDTLFLQVNAFTGTITQELGLISSLKSMDLSNNMFTGEIPTSFSQLKNLTLLNLFR... | 99 |
Q54Y26 | 2.7.11.1 | ACT_SITE 235; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MINDHESVIDVGSDDERENFEDEEDTTTVYSSDPLSRPTMDRSLAAKMYIEQYYINAQQSVKERGQRRKDLELKLENMKLSSKESNDLRKELDKKESDYMRIKRLKLKRSDFEVIRIIGRGAFGEVSLVRHRESNDLYAMKRLKKSEMLKKEQAAHVRAERDVLASANTNWVVKLYYSFQDDNYLYLIMEYLPGGDMMSLLIKYDIFTENQARFYIAETILAIESVHTLGYIHRDIKPDNLLLDSKGHVKLCDLGLCTGFHRLHSSEFYQMLVGDAMTIKMKLIEATPLTQTERIASWKKARRALAYSAVGTPDYTAPEV... | 99 |
A0A3B5Z1E6 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASRAATMVALLLAAVAATCARAQLHEKFYGESCPSVEDVVRKEMVRALSLAPSLAGPLLRMHFHDCFVRGCDGSVLLDSANKTAEKACPDTVSCADILALIARDAVWLSKGPFWTVPLGRRDGSVSISNETDALPPPTSNFSVLTQLFAAVNLDAKDLVVLSAGHTIGTSHCFSFSDRLYNFTGMENPSDIDPTLEPQYMMRLKSKCVSLNDNTTLVEMDPGSFKTFDTDYFKLVSKRRGLFHSDGALLTDPFTRAYVQRHATGAFKDEFFADFAASMIKMGNANPLIGSQGEIRKKCNVVNH | 14 |
A0A3Q2HA18 | 3.1.4.11 | ACT_SITE 358; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 405; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSVRLGASPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNELLHALWVTDHLKFWCDGQEPCFLLKKEDTLHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKTKGLISSD... | 153 |
M1BVU0 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATLKFLCFLILQLFLVANCEGVEVGFYNETCPNVEIILKETTKHYISIAPTLAAPLLRMHFHDCFVRGCDGSVLLNSTKGNKTEKDEIPNQSLRGFQVIDATKSALEKECPGIVSCSDILALTARDAVSMINGPTWPVPLGRRDGIVLILLEASKNLPTPFDNFTTLKTTFGALGLNVKDLVVLSALLTNTQTKDYVLSQLYLHGSTFFKDFGESMVKMRQIGVLTGKAGEIRKHRAFRN | 14 |
D7UPN3 | 2.7.11.1 | ACT_SITE 436; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MFSLPALLIGACAFAAAAVAASGDGCRAGCSLAIAAYYFSEGSNLTFIATIFAIGGGGYQALLPYNPAITNPDYVVTGDRVLVPFPCSCLGLPAAPASTFLAGAIPYPLPLPRGGGDTYDAVAANYADLTTAAWLEATNAYPPGRIPGGDGRVNVTINCSCGDERVSPRYGLFLTYPLWDGETLESVAAQYGFSSPAEMELIRRYNPGMGGVSGKGIVFIPVKDPNGSYHPLKSGGMGNSLSGGAIAGIVIACIAIFIVAIWLIIMFYRWQKFRKATSRPSPEETSHLDDASQAEGIKVERSIEFSYEEIFNATQGFSME... | 99 |
Q9FAB3 | 2.7.11.1 | ACT_SITE 148; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTPDSRHRRLLANRYQLVELVGSGAMGQVYRAEDKLLGGVTVAVKFLSQALLNPRMKERFEREATISALLGEKSIHIVRVRDYGLDEKEIPFYVMEYLQGENISDVIKYRPLKVERFLKIARQICFGLDCAHKGIIYQGEACPVVHRDIKPSNVLLVEDPALGELVKILDFGIAKLVQAAEESKTQAFMGTLAYCSPEQMEGKELDSRSDIYSLGVMMYEMLTGEMPLFPDNSSFGGWYEAHHHTKPHPFSARYKIPASLEALVMNCLAKSPKGRPQSVDVIIRAIDAIEAEIKAPPISDTEKTQIAPHLLNTDMEATVV... | 99 |
A0A804IVR3 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASKSLFVFFLPLVLSPFFSGCAEAQGGLRVGYYSQTCPKAEAIINAEMRKIIKYAPSLGGPLLRLHFHDCFVRGCDASVLLNSANGQAAEKDGIPNQSLGGYGVIDVVKVKLEKACPGVVSCADILALVARDVVALSKGPYWQVPTGRRDGTVSIASEAFQLPRPTDGISQLIQNFAGKGLSVQDLVVLSGAHTIGVSHCSSFSSRIYGSDPSIDPKYAATLRMKCKPKDLTTLVQMDPGSVTTFDTGYYKQVSGNRGLLNSDAALLQNPQTKAYVLRQSTGSASQFFKDFGDSMVKMGNIGVLTGAAGQIRKKCFAVN | 14 |
Q9P7S5 | 3.4.19.12 | ACT_SITE 217; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 812; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MPHSNTLIVPSTNPFDDPSSIKNGLNNLTSSELVNQMKKESLAASVKTPSTPPKECSHLKKGVKLSHLKGNARALRDPSKHLCFICTTEKIKREDYELTLCANCGYLFCCNHESDHSRKHFEKNKKHCVFVNIITLKCHCYSCDADIVIFDKKNLVVRDVQQFICSNLVSSLTKAPNVLKSNSSHFKKEKKSKHSSGKSSKKYKVISPGLKNLGATCFFNSTLQVLCACEALHDVISPFQYSHSSVIVRKLTKSPESSLLSAFIKFLETFYKSDGTISVYRPTTFFGEFRRLHPQFSESVQQDAHELLRLLLDDLISEEF... | 175 |
M5W7I6 | 2.7.1.11 | ACT_SITE 303; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MGTLSHAAIAPRLAALHHHRASHGLSHPSSPSLRLPASNGVAKKSRVPFAQSKSHNQDIDFSDPDWKSKFQRDFERRFNIPHITDVFPESVPIPSTFCLRMRTPVIEDFAGGYPSDEEWHGYINNNDRVLLKTIYYSSPTSAGAECIDPNCTWVEQWVHRAGPREKIYFKPEEVKAAIVTCGGLCPGLNDVIRQIVITLEIYGVKKIVGIPYGYRGFSDKELAEMPLSRKVVQNVHLSGGSLLGVSRGGPSVSEMVDSLEERGINMLFVLGGNGTHAGADAIHNECRKRRLRVAVVGVPKTIDNDILLMDKTFGFDTAVE... | 84 |
Q0UF94 | 3.2.1.52 | ACT_SITE 385; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MNLIILLPLFLSSASALWPKPVSYTHGNTVLFIEKSVSFLWYGSGTRNVGSIADQHPDQQPFVFVSNSNDRSETQEHLKLRKRYTEVSLDSRSSNGSQAVSGDEIIDYAIKSAYSTIFTQNFVPWKYHPRGWEEPSPGKTVSEVKINLLKNDPENVSRPLAGEVDESYTLTLTEDGKATVSANSSIGIAHGLNSFTQLFYAHSDGTHVYTPLAPVSISDAPKFQHRGINLDVSRNYFSVADIKRQIDALAYNKMNRFHLHITDSQSWPLVIPSLPTLAAKGAYRPDLVYTPQDFADIQRHAAIQGVEMITEIDMPGHTAS... | 170 |
F6UPH6 | 3.1.3.48 | ACT_SITE 486; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000929-1" | MTSRRWFHPNIGGVEAEQLLLSQGQHGSFLARPSRSCPGGFTLSVRWVVPWPGVDSLRSQEASKGLSTLSCRRRRHDEVTHIKIQNTGDYYDLYGGEKFATLAELVQHYMDQRGGLLRERSGAPVELRHPLGCQDPTTERWYHGHLSGKEAEKLLMEKGRPGSFLVRESQSKPGDFVLSVLTQQPDKADRRPRVTHVMIHFQPDGKFDVGGGEQFHTLGDLVERYRKNPMVEKSGAVVHLKQPLKATRINAASIENRVQELSKTTEATEKAKQGFWEEFEMLQQQECRLLFPRKEGQRPENKPKNRYKNILPFDTTRVAL... | 149 |
B7PKT6 | 3.2.1.143 | ACT_SITE 113; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 131; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 132; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MQVACLLANAFFCTFPRRNTLKSSAEYSHYPDINFVRLYSGPSDEDCKMEKLKCIINYFRRITSDEPKGMLTFHRKGLSESIEWSRSKDSLTDLHVSEKGFIEREGRGMLQVDFANKFVGGGVLGGGCVQEEIRFLVCPELLVSRLFTEALGPKEVLVITGVEQFNDTAGYADTFSWESDFLDDTPRDSWGRRCTAVVAMDALYFARPHEQYRPIAIRRELTKAFCGFSCPGVPEGKRAAVATGNWGCGAFRGDPQLKSLLQLMAAAVAGRDVVYFTFNDRRLCRNLRNMHRFLRERNLCVGDIYELLMQYHQDCASKNI... | 159 |
Q8ZNL2 | 3.1.3.3 | ACT_SITE 92; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 94; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MSIIYFITTQDIDTFQKKLQETLFNAVTMPFPLLFDKRYAALINTAYLKLTLPAECLTPEFYRYLRELSLQWQFDFFIKPQPLPANGIIAFDMDSTFIAEEGVDEIARELGMSTQITAITQQAMEGKLDFNASFTRRIGMLKGTPKAVLNAVCDRMTLSPGLLTILPVIKAKGFKTAIISGGLDIFTQRLKERYQLDYAFSNTVEIRDNVLTDNITLPIMNAANKKQTLVDLAARLNIATENIIACGDGANDLPMLEHAGTGIAWKAKPVVRKKIHHQINYHGFELLLFLIEDEL | 147 |
Q9ZNQ8 | 2.7.11.1 | ACT_SITE 408; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASSPESAPPTNSTSSPSPPSNTNSTTSSPPAPSPPSPTPPQGDSSSSPPPDSTSPPAPQAPNPPNSSNNSPSPPSQGGGGERGNGGNNGGNDTPPSRGSPPSPPSRSNGDNGGSRSSPPGDTGGSRSDNPPSSGGSSGGGGGGRSNTNTAIIVGVLVGAGLLMIVLIIVCLRRKKKRKDSFYPEPMKGNQYQYYGNNNNNNASQNYPNWHLNSQGQNQQSTGGWGGGGPSPPPPPRMPTSGEDSSMYSGPSRPVLPPPSPALALGFNKSTFTYQELAAATGGFTDANLLGQGGFGYVHKGVLPSGKEVAVKSLKAGSGQ... | 99 |
Q8P8V4 | 1.3.5.1 | ACT_SITE 290; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MSAYKITEHKYDMVVVGAGGAGLRATFGLAQKGLQTVCLTKVFPTRSHTVAAQGGISAALGNMGEDDWRYHFYDTIKGSDWLGDQDAIEYMCREAIPAIIELEHYGVPFSRTEEGKIYQRPFGGMTTKYGEGPSAQRTCAAADRTGHAMLHTLYQQSLAHNARFMIEYFALDLIFDEEGVCRGVLALDMAEGSLHLFRAHGVVLATGGYGRAYFSATSAHTCTGDGGGLVMRAGLPMQDMEFVQFHPTGIYGAGCLITEGVRGEGGILRNSNGERFMERYAPHYKDLASRDVVSRSMTIEIREGRGVGEHKDHILLDLTH... | 28 |
P57080 | 3.4.19.12 | ACT_SITE 178; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 608; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MTVEQNVLQQSAAQKHQQTFLNQLREITGINDAQILQQALKDSNGNLELAVAFLTAKNAKTPPQEETGYYQTALPGNDRYISVGSQADANVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPIEVWRDSRNPYDRKRQEKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAMGVLEGKKFENTEMF... | 175 |
Q58897 | 3.1.26.11 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01818" | MIIMKLIFLGTGAAVPSKNRNHIGIAFKFGGEVFLFDCGENIQRQMLFTEVSPMKINHIFITHLHGDHILGIPGLLQSMGFFGREKELKIFGPEGTKEIIENSLKLGTHYIEFPIKVYEIYTKEPITIYKEENYEIIAYPTEHGIPSYAYIFKEIKKPRLDIEKAKKLGVKIGPDLKKLKNGEAVKNIYGEIIKPEYVLLPPKKGFCLAYSGDTLPLEDFGKYLKELGCDVLIHEATFDDSAKDAAKENMHSTIGDAVNIAKLANVKALILTHISARYDKEEYFNLYKMNVKQYNESFKIIISEDLKSYDIKKDLLG | 137 |
Q8ECU9 | 4.2.1.20 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MNSISNQTIPHQASRYQAAFSRLKAEGRGAFVPFVTLGDPSPELSLKIIDTLVQNGADALELGFPFSDPLADGPVIQGANLRALAAGTTPTACFELLAKIRAKYPELPIGLLLYANLVFANGIDAFYAKAQQAGVDSVLIADVPVEEAAPFIQAAKAHGIAPIFIAPPNADSDTLAKVSQSGEGYTYLLSRAGVTGADTKAGTPVEEILAKLQEFNAPPPLLGFGIAEPAQVSAAIKAGAAGAISGSAVVKIIETHQQDEVKLLAALGEFTRTMKAAT | 202 |
A0A022QPR6 | 3.1.1.11 | ACT_SITE 215; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNNSGSVRCRTKGMRPRKSGNSSSVDTTQVEQSEQQFLKWVDFVGSLKHSRFKTAKNKVFPSYTLTVDRNPQLGDFTSIQDAIDSLPLVNLVRVVIKIHAGVYTEKVTIPTMKSFITIEGASAEKTVVQFGIPLGTYGSATFAVNSPYFIARNITFKNTTPVPPPGAVGKQAVAFRISADTAAFVGCKFLGAQDTLYDHLGRHYYKDCYIEGSVDFIFGNGLSLFENCQVHAIAPIIGAVTAQARSSILDDSGFSFVNCKVTGSGALYLGRAWGPFSRVVFAYTYMDNIIIPKGWYNWGDPSREMTVFYGQYKCTGAGAN... | 125 |
Q67E00 | 2.7.12.1 | ACT_SITE 768; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQKDGTRSSRRMEEGDRRNGSTGSSGSVSRELGRGFSYYNKYLARLQQNLRDTKRFFRDIKHTYSGAPGGPDTDIKGAEGDLGQLHSITFPRQEEEYLKLTVRCRPCIFILGQSCSSRGRVANSLLGDQLLPILTHCGSECCKRRRIRFRYGKQTLVSLALPEQYELVHELVAHQGKWDTIPEEDLDVPEDEEDPAHRLAELEVTLPHQLLQDVDIVVSPCRSSQAVSMTLEDYVDHVQSIVVYAVCEERLSQQDEEELTEIKEKYKLPVFFIRTSSTRDRLIGGSEGVRSALYEQLMELGFLKRGLCNCGAAGSGSTAP... | 107 |
P06243 | 2.7.11.1 | ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKKFASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEAQMDYKSMISSQNDYDNYANTNHDGGYSMRNHEQFCPCIMRNQYSPNSHNQTPPMVTIQNGKVVHLNNVNGVDLTKGYPKNETRRIKRANRAGTRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMF... | 99 |
B7PUB2 | 4.1.1.17 | ACT_SITE 327; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | SQCQGEHGSVSYQRFNAMPTSSQTADGAFFVCDVRDLEHKVDLWRQELPGITPFYAVKCSTDPVVLHTLSSRGVNFDCSNMSEIKMVLEMGVSPDRIVYANTIKSSSHLDFASEHGVTLMTFDCMEELGKISDKNARLLLRIASNETGSGITMNNKFGCRLEEAGNLLQIARYMGFNVVGIAFHVGAAYRCPDIFARSIAEARSVFNVGIRIGHPMTVLDIGGGFTGGLRSHDRLLKLCETIRVAVDEYFPASSGVRVIAEPGQFFVTSAYTLATRVVAERRKDIEINGEFGQKYNEIKYTVCASGHAQPPHERPCNILS... | 195 |
Q9M1Z9 | 2.7.11.1 | ACT_SITE 429; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPSELKVLHIVLVLLYTLSSSTYNSNGNWTLEGSAADNSIGDTILTNTKKHSCGQTFNNESIPIKDSSFSFHFLFGIVPEHTQSGSHGMSFVISPTAGLPGASSDQYLGLFNETTNGKSSNHVIAIELDIQKDQEFGDIDDNHVAMVMRLSIVYSHPDQQLNVTLFPAEIPVPPRKPLLSLNRDLSPYFLEEMYYGYTASTGSIGAFHYMLSSYATPKVENPTWEFIVVPTLPPYPKKSSDRTKKILAVCLTLAVFAVFVASGICFVFYTRHKKVKEVLEEWEIQYGPHRFAYKELLNATKDFKEKQLLGKGGFGQVFKG... | 99 |
Q5AIR7 | 3.2.1.39 | ACT_SITE 892; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 969; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352"; ACT_SITE 973; /evidence="ECO:0000255|PROSITE-ProRule:PRU01352" | MLFKSVLLSTLIAVQALAENSAHQEIVTVTKTTHISNPCLENYAKKLLPNNPTGLTTGIPIVIVYAPQQPDNQVKQSESLQPTQSSKAQQQQQIQGSSVPASIHDTPTPTDHTKITVTSTTICNQKVCTVKTFSTIISHSESPTTTTTTKQNEEKSIADTKSFTHKALPSSNGAVTLKTTSVKTALTTTSTVFSATSLPSTTYTPSTSVSLVSTTKKNPVSSQSVVSTTKTISINTSLITDAVTITKEATTLPNSKHSSIFTNGSISFISTSANKVKSTVTSDISNNSQNGSSLSLTSTINQLASITNSTLTTITKPTSL... | 167 |
A0A2K1KFL2 | 5.3.1.8 | ACT_SITE 288; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MLRLLCAVQHYEWGRIGAASEVGRLHALASGEDVEDIPYAELWMGTHRSGPSRVVAEDKSEVLLKDWLDTHPEALGQNVIERWEGELPFLFKVLSVAKALSIQAHPDKKLGQYLHETQPHNYKDANHKPEMALALTPFEALCGFVTPEELKQAVETVPELRSVLGEATSEALIQLGQCKVSGDESKRKLKEAYTILMTLRNDVVSSTVSQLVIRLVEEKEVRQLTEKEELVLRLEKQYPADIGVLSIFFLNYLRLSPGEAVCLGANEPHAYLSGEIIECMAASDNVVRAGFTPKYRDTQTLCSMLTYKQGLPDMLTGTPV... | 214 |
A0A7I4F556 | 1.11.1.7 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MHVSSGEGTETMDRLAALLIALFCLLATVLKVESEGLVYDYYANSCPNAEKIIHDTVYKLYEKKGNIATSLIRYVFHDCFDSCDASVLLESSKGVPAEKESHSQVGMRNGKWINNIKKAVEDSCPGVVSCADVLALGGAAGAQVLGGPAIKLKTGRKDSRVSLKSVADTGIPTPQSNVSFVLDYFSKMGINTEETVALLGAHTIGRAHCVSFEERIYPTVDPKMDPVFASMLKYRCPQQKTGAEPVHFTYFRNDEQSPMAFDNHYYVNLMANQGLLHIDSEIAWDSRTKLFVVEYAKDNALWHKNFATAFTKLSEHNPLT... | 14 |
E9QFH2 | 2.7.11.22 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR628788-1" | MDKESSTQQYEPVAEIGEGAYGKVYKARDLKNGGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLESFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLEKAPDPGVPPETIKDMMYQLLQGLDFLHSHRVVHRDLKPQNILVTSGGQIKLADFGLARIYSFQMALTSVVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRRPLFRGNSDVDQLGKIFDVVGVPSPEDWPQEVGLPQSAFSPRPAQPIENLVPDMDELGKSLLLSLDSTSKSLYAQPFPSKKPSLEERAA | 102 |
Q9LFV3 | 2.7.11.1 | ACT_SITE 239; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVNRSDLVVIGISVGLALGLLLALLLFFAIKWYYGRSHLRRCANEQNSPTLPVHTAKRGVVIPDDRANTESSQPPENGAPTQHQPWWNNHTKDLTVSASGIPRYNYKDIQKATQNFTTVLGQGSFGPVYKAVMPNGELAAAKVHGSNSSQGDREFQTEVSLLGRLHHRNLVNLTGYCVDKSHRMLIYEFMSNGSLENLLYGGEGMQVLNWEERLQIALDISHGIEYLHEGAVPPVIHRDLKSANILLDHSMRAKVADFGLSKEMVLDRMTSGLKGTHGYMDPTYISTNKYTMKSDIYSFGVIILELITAIHPQQNLMEYI... | 99 |
Q8F0Q0 | 1.11.1.24 | ACT_SITE 47; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MSELKTGAKAPGFSALNEKGEKVKLSDLSGPKGTVLYFYPKDQTPGCTTEACDFRDNFSRIKKTGFNVVGVSKDSVKSHQKFIEKQELNFTLISDEDGKICEDYGVWQMKKFMGREFMGIVRTTFLIGADGKILKVYPKVSVKGHVDEILSDIKTLEKK | 12 |
G1KJF5 | 2.7.10.1 | ACT_SITE 1033; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MELTAPLGLFFLLLLLAEPRRVHSDSPVSLDPPLLSTQKSLITVTENDTLQITCSGERALEWFWPNNQTSSENRVAVTDCTENAYCKLLTLSKVKGNDTGAYKCFYQDNHTAASVYIYVQDFTDLPDYRSPFLKSASEKPDAIYITGNKTVVIPCLGSTSNLNVSLHTKYPDKVFVPDGKAKTWESQKGFTIPTSLISDVGIVFCKAKIDGESYQSLMYIVVVLGYRIHDLAMSPPHNVALAAGEKLALNCTARTELNMGIVFEWDYPSKKAAANKNNKHVIIRDGVTSPSNEEKKFVSSLTIDHVDLKDGGQYRCTASS... | 97 |
F7HC17 | 2.3.2.23 | ACT_SITE 385; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10133" | PLPAAAPIPLQEWRSGVCSGPPPGRAAVSGAAQRQAGREGRRGAARGGLGPCRPCPPPASPFPHPGTRSPPPSPCFGFLSYSFPPLLSSRPRQTPLVAPQSLTRATGPPPHDPRKADKNSPEAGRLPGPSLPAPPWRPAPPPCPPSPPGLLPPCPAESPGGRGRGRSPSSRPFSHSVPHLGPKINKPRPICKSLNGPADFEKRVEGGGRPRAPLVNALLTAPEFLIYTGCMVCVFLFCFPPPAGAVCGVGWGFAMSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPN... | 64 |
B7P242 | 2.5.1.18 | ACT_SITE 17; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MAAPTKVAVELFYDVISPYSWLAFEALHRYRTPWNLDLKLRPFFLGGVMKESNNRPPAMVPNKAAYMQADLRRSSKLFQVPIKVPDFFFEFITTKSTINAQRFLVALQLRQPQFLEEASRGFWKRFYQDNKDIAEEDSIAAVGQAIGMDAATLKETLGLMKDDSVKEGLKKNTSDAVDVYGAFGAPTIVAHVPGGKPEMFFGSDRFEQMACVLGKQWHGPVLPQGAKL | 77 |
Q588C6 | 2.1.1.37 | ACT_SITE 614; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MRKEEIKKSTEIVMPSNKYPSAESDKMTATAAMNRDTSVGDGLSENDSGLEMTSENSPLTPAEPPSPFCPKQNGGAASPADESVNSIRRKRSRKRSDTEEDSAWDSSYSEEKAEVGSGCETGLRQRPRPRTIFQAGLTAHSKPRSRERGHSKEDHSDLVASVPEGPALELMEQDSKDSAQSSTTSTSTTETASQPEYKDNKGFGIGELVWGKIKGFSWWPGMVVTWRATGRRQASHGMRWLQWFGDGKFSEVSADKLDSITAFPKFFNQSSYTKLASYRRAIFQALEVASLRAEKTFPPSEADSLEEQVKPMLDWAHGGF... | 47 |
A0A9J7N4H4 | 3.1.1.4 | ACT_SITE 72; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 120; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKVVLAAAILLVVGFGFEGAVGKPTRSVLQFGAMISHVTGRNPFDYLDYGCYCGLGGSGTPVDDIDRCCEVHDACYGAVDSSDGVGTAHLINYHFTQEAGGLVTCDDRFGTVAREACECDREAAFCFDRYPYPGRQPC | 130 |
A0A022PS95 | 3.1.1.11 | ACT_SITE 389; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASTNQPLLHKTKSNCKFIFFTISISALVISAVLLLPNQYQSNSKTSHLCSRALNPQSCQDFVSEVTSDNSAIAITPQQDGTTLLQKFLIRQAHHMSRAISQTRKLKNRMNAQIERGALADCLHLIDLSIDLVLDSIRDLNNETSAMSRDNARAWLSGVLTNHVTCFDGLDSFEKQYLGEVIEDLIERASASLAVFAVAVSKLDHNEVDIPSFGQNYMPSWITKVERQLLQSTADAVAADLTVAADGSGNYKTVAEAVAAAPDKSKKRYVIYVKKGTYKENVEVGKNKKNLMIIGDGMNNTIITGDLNVADGATTFNSAT... | 125 |
P56076 | 5.3.1.1 | ACT_SITE 90; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 159; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MTKIAMANFKSAMPIFKSHAYLKELEKTLKPQHFDRVFVFPDFFGLLPNSFLHFTLGVQNAYPRDCGAFTGEITSKHLEELKIHTLLIGHSERRTLLKESPSFLKEKFDFFKSKNFKIVYCIGEELTTREKGFKAVKEFLSEQLENIDLNYPNLVVAYEPIWAIGTKKSASLEDIYLTHGFLKQILNQKTPLLYGGSVNTQNAKEILGIDSVDGLLIGSASWELENFKTIISFL | 213 |
A0A2C9VE43 | 3.1.1.11 | ACT_SITE 265; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRIRTFSFWLFAFAIALISIIISISAILPSSLTTAPIKVPDSFQLLILRRVFKETGLEDTISRILSRHHHHHHHHHHHHHRKKPKCDRNSWKSRIMYRYGRVIYHYKVSSVLTVDLKGCANFSSVQKAVDVAPDFSPFPTLIIIDSGTYREKVTVHNSKTNLIFQGQSYQNTAIEWNDTANSTGGTVYSASVAIFALNFRAYNISFKNTAPSPSPGEVGGQAVALRIAGDQAAFYGCGFYGAQDTLHDDRGRHYFRECFIQGSIDFIFGNARSLFEGCIINSIAKPPVAGVSGSVTAQARQSMSEQTGFSFVKCIVVGSG... | 125 |
Q25BW5 | 3.2.1.21 | ACT_SITE 170; /note="Proton donor"; /evidence="ECO:0000269|PubMed:17376440"; ACT_SITE 365; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:17376440" | MSAAKLPKSFVWGYATAAYQIEGSPDKDGREPSIWDTFCKAPGKIADGSSGDVATDSYNRWREDVQLLKSYGVKAYRFSLSWSRIIPKGGRSDPVNGAGIKHYRTLIEELVKEGITPFVTLYHWDLPQALDDRYGGWLNKEEAIQDFTNYAKLCFESFGDLVQNWITFNEPWVISVMGYGNGIFAPGHVSNTEPWIVSHHIILAHAHAVKLYRDEFKEKQGGQIGITLDSHWLIPYDDTDASKEATLRAMEFKLGRFANPIYKGEYPPRIKKILGDRLPEFTPEEIELVKGSSDFFGLNTYTTHLVQDGGSDELAGFVKT... | 161 |
Q74BY3 | 6.3.4.2 | ACT_SITE 381; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 507; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 509; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MKTKFIFVTGGVVSSIGKGLASASLGALLESRGLRVTMQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERYTSARLSKRSNFTTGQVYFSVIEKERRGDYLGGTVQVIPHITDEIKHKILENAKGADVAIVEVGGTVGDIESLPFLEAIRQFKADRGAGNVLYIHVTLVPHIKTAGELKTKPTQHSVKELREIGIQPDILICRCEMELPRDMKAKIALFCNVEEKAVITSTDAEHIYAVPLALHKEGLDEQVVEKLNIWTKAPDLSPWHSVVEKLRSPLRGEVRIAIVGKYVNLTESYKSLSEALTHGGIAN... | 252 |
Q7XSU6 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAARRLPVLELVSFVAVLLISSPTAAAAELSVDFHAASCPPLEAIVRSSVQAALQQEIALAAGLLRIFFHDCLPQGCDASVYLRGGSNSEQGMGPNLTLQPRALQLVDDIRAKVHAACGPTVSCADISALATRDAVVVSGGPSYAVSLGQKDSLAPAPVRLVNQLPGPGTSSVQALLDKFGSKGLREAADLVALSGAHTVGRAHCDFFRDRAARQDDTFSKKLAVNCTKDPNRLQNLDVVTPDAFDNAYYVALTRKQGVFTSDMALIKDRITAPIVRQFAADKAAFFRQFAKSMVKLSQVPRTDRNVGEIRRSCFRTNG... | 14 |
A0A8I3Q0T5 | 3.1.3.16 | ACT_SITE 178; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 180; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | LRPKAGARERGGGGWARQSGGGCPALGRRSGRGEGGGGGAGRWLRDTGRGPHSRPLGPALLRTLDPRGRKGWEERGSGRRGPRPQPSWVGAPPSRGCARPGGCPGEQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAVPKQTPVQYLLPEAKAQDADKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLL... | 144 |
P51566 | 2.7.12.1 | ACT_SITE 240; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MQSSVYRDKASSIAMILETQRNVEFPHRIVDKRPRKRPRLTWDAAPPLLPPPPPPTVFQPPLYYGPEFASGLVPNFVYPNMFYNGLPRQGSPPWRPDDKDGHYVFVVGDTLTPRYQILSKMGEGTFGQVLECFDNKNKEVVAIKVIRSINKYREAAMIEIDVLQRLTRHDVGGSRCVQIRNWFDYRNHICIVFEKLGPSLYDFLRKNSYRSFPIDLVRELGRQLLESVAYMHDLRLIHTDLKPENILLVSSEYIKIPDYKFLSRPTKDGSYFKNLPKSSAIKLIDFGSTTFEHQDHNYIVSTRHYRAPEVILGVGWNYPC... | 107 |
A0A251RY77 | 3.4.19.12 | ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 124; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 139; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MEGPINGGMLYHEVQESKLCAVHCVNTVLQGPFFSEFDLAALASDLDRREHQMMLEGSAAAAGDAFLTEESFNVSMDGDFSIQVLQKALEVWDLQVIPLHSPVAEPAQVDPELENAFICHLQDHWFCIRKVNGEWYNFDSLYAAPEHLSKFYLSAYLDTLKGFGWSIFLVRGNFPKECPMTSGETTNGFGQWLLPEDAERIIKSCNSGQRQQHHQQQQLQPPRTPPMEEDDDLNAAIAASLRDTAGEAGTSGNDHDDDLEAAIAASLKDSSPAVVNKENDAVTAPAAVATLTDTTPPATPVTGGEDENESKKSGLQDK | 175 |
Q10E50 | 3.1.1.4 | ACT_SITE 99; /evidence="ECO:0000255|PROSITE-ProRule:PRU10035" | MARGGSFSRLRLRAGVVVAAAAAALLLFAVVAPPAAALNIGLQSAGDGASKAGLCSRTCESDHCTTPPLLRYGKYCGILYSGCPGEQPCDELDACCMHHDNCVQAKNDYLSTACNEELLECLARLREGSSTFQGNKCMIDEVIDVISLVIEAAVVAGRLLHKP | 130 |
B7PP47 | 3.1.3.48 | ACT_SITE 132; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR037322-1" | MDSSDEEVSGDYLKPATPLKIDWLDLSMFGYPDSVGLSGLPGCKFKDSWRDTAHDLEYLKLEDVSDVFVLCTRGELTLYRVPSLLTEYESHGITVHHHPFQDGTAPGIEQVLNILKEIGKVIEQGKRALVHCFGGLGRTGVVAACLLLNLDDGVTPEYVVRKVQELRGTRAIQTVKQYNFIHDFRSLRDMYLGDSDSKLATE | 149 |
Q54YF2 | 2.7.11.1 | ACT_SITE 154; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSYQQNPIGSFGGLYGSGGIEKSSQIIGNYRLDKTLGIGSFGKVKLAEHIRTGVKVAIKILNRTKIKNLKMDEKIRREIQNMKLFRHPHIIKLYEVIETTTDIFMVMEYVTGGELFEYIVKNGKLLEDESRRLFQQMISGVDYCHHHMVVHRDLKPENLLLDPINKCIKIADFGLSNMMQDGDFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYAFLCAKLPFDDESIPMLFKKIREGVFSIPDFVSPSCADLIKKMLVVDPVKRITIHEIRNHPWFQVKLPKYLSSPHTFLSKSIQTINNSILNEMVQVYAP... | 99 |
A0A1L8HBD3 | 2.3.1.181 | ACT_SITE 174; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MSVLRVRRLGLVSYAEALAEQARCVRAVREERVGREGRLLLCEHPPVYTVGIRRAAYPGEEESRLRALGADFHRTDRGGLITFHGPGQLVCYPVFHLRDLRLSLRSYVSGLESSVISLCNRLGLPGETNPETGVWVRGNKICAIGVHCARYITSHGLALNCNTDLSWFSHIVPCGIVGKGVTSLTRELGRQVTIDDIIPAFLEAFEEEFQCSLLMEQN | 55 |
K4AC48 | 1.11.1.7 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MPSTSLANMATAATSSKMPVLAALTLLLLAVACRASPYYPLELGYYRYKCPQAEAIVKAVMEKAIGQNPGNGAAVIRMLFHDCFVEGCDASILLDPTPFSPTPEKLSPPNNPSLRGFELIDAIKHALEAACPGVVSCADIIAFAARDASCFLSHGRVSFDMPAGRLDGTFSNASEPLKFLVPPTSNLSDLISSFVVKGMSVEDLVVLSGAHTVGQSHCSSFVSDRLDVPSDINPGLAGFLRSRCPANATSGSGDDPTVVQDVVTPNDMDSQYYRNVLSHTVLFTSDAALLTSPETAKMVVENAKIPGWWEDRFEKAMVKM... | 14 |
P27934 | 3.2.1.1 | ACT_SITE 204; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00693"; ACT_SITE 229; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P00693" | MGKHHVTLCCVVFAVLCLASSLAQAQVLFQGFNWESWRKQGGWYNFLHEKVEEIASTGATHVWLPPPSHSVSPQGYMPGRLYDLDASKYGTEAELKSLIEAFHDKNVECLADIVINHRCADYKDSRGVYCVFEGGTPDGRLDWGPDMICSDDTQYSNGRGHRDTGAGFGAAPDIDHLNPRVQRELTDWLNWLRTDLGFDGWRLDFAKGYSAPLARIYVDNTNPTFVVGEIWSSLIYNGDGKPSTNQDADRQELVNWVEGVGKPATAFDFTTKGILQAAVQGELWRLHDGNGKAPGLMGWMPDQAVTFVDNHDTGSTQSLW... | 157 |
M4D5C6 | 1.11.1.7 | ACT_SITE 462; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKPRMGSFKKRSSSKNLRYSMKRRTSSKVTPVEIEDVHDAEELKSVDAFRQALILDELLPEKHDDYHMMLRFLKARKFDLDKTKLMWTEMLRWRKEFGADTVMEEFEFKEIDEVLKYYPQGHHGVDKEGRPVYIERLGQVDSTKLMQVTTLDRYVNYHVMEFERTFNVKFPACSIAAKKQIDQSTTILDVQGVGLKNFNKAARDLVTRLQAVDGNNYPESLNRMFIINAGSGFRMLWSTVKSFLDPKTTAKINAKEVYAIQEACNTATSDGGRSPIFTGVMALVMGVVTMIRVTKNVPRKLTESTLYSSPMYCDDASMNK... | 14 |
P9WH77 | 1.17.4.1 | ACT_SITE 389; /note="Proton acceptor"; /evidence="ECO:0000250"; ACT_SITE 391; /note="Cysteine radical intermediate"; /evidence="ECO:0000250"; ACT_SITE 393; /note="Proton acceptor"; /evidence="ECO:0000250" | MPGERRRFAQATKSVGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGGTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTD... | 21 |
A0A8J1LQX7 | 2.7.10.1 | ACT_SITE 919; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MGVHKYWQGEELALPLKFCLPLAPCPLPQIAVKIQDGHVFHCGKHNHLGFVTDTRHRDSEASSVGTAGKKKFGVTGPGQTYNLKCLPYWLYRAPLKVKQTVEIWYLFSFPPLFSIAVCAGTDNKLSSLSDLEQQYKALRKYYENCEVVMGNLEITSIEHGRNLSFLRSIREVTGYVLVALNQFDYLPLENLRIIRGIKLYEDRYALAIFLNYRKDGNYGLRELGLRNLTEILNGGVYLGQNKFLCYADTIHWQDIVRTPNATLVPMASNAECGRCPKSCMGRCWGPSDQHCQRLTKTVCAEQCDGRCYGSYVSDCCHREC... | 97 |
P26570 | 3.1.3.16 | ACT_SITE 480; /note="Proton donor"; /evidence="ECO:0000250" | MGNSSSKSSKKDSHSNSSSRNPRPQVSRTETSHSVKSAKSNKSSRSRRSLPSSSTTNTNSNVPDPSTPSKPNLEVNHQRHSSHTNRYHFPSSSHSHSNSQNELLTTPSSSSTKRPSTSRRSSYNTKAAADLPPSMIQMEPKSPILKTNNSSTHVSKHKSSYSSTYYENALTDDDNDDKDNDISHTKRFSRSSNSRPSSIRSGSVSRRKSDVTHEEPNNGSYSSNNQENYLVQALTRSNSHASSLHSRKSSFGSDGNTAYSTPLNSPGLSKLTDHSGEYFTSNSTSSLNHHSSRDIYPSKHISNDDDIENSSQLSNIHASM... | 144 |
D6WG65 | 3.4.19.12 | ACT_SITE 329; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 756; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MELLTPHLSSVRVPTATSKVYKDECVFSFDNPETETGLYVGLKSFFGLGRDYVEKHFHKTGEAVYLHIRRVRHEVSSPPQGDGPEKKITRLAIGVDGGFDPEAMSKKFEFEDSYNIVVLPGFSTIPWPNTELPQIVKSSIEGILEAPSASKVAEMEALTGTWDGEARVVSQFAHNLPQLDNGKKIPPSGWQCEKCDKTDNLWLNLTDGSILCGRRFYDGSGGNNHAIEHYNATGHPLAVKLGTITKEGKGDVFSYKEDDMVEDPNLVQHLAHWGINIANMEKTEKSMVELELELNQKSNEWSALQESDGQLKPIYGPGYT... | 175 |
E3KKP2 | 1.11.1.6 | ACT_SITE 102; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 176; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MLQSARILLSVAHLLPCIIQRSESSSLPNETTSSSQQLPGNLNASSFQIPSLSSILPSANSTKALNGLNGLASPAPIAPLSPDALAKQSEFDRKNIPARPVHAAGAGAYGTFTVTTNFAQSQTSMDLFSNVGQTTPVTVRFSNALGEKGSFDTARNVRGFAMKFQTKQGAWDLVSNNAPVFFIRDPAKFPPLIQSQSRDPLNNLGNADTAFNYFPNNPETMNMFLRIFSSAGASRGWIHTNAWSINTYRWYKSDGTWSYVRINFETKQGVLNFTASEQAQISDPSYGARELYSSIQAGQFPRWTMFAQVLSPKDAENFRY... | 13 |
A0A9R1VL19 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEIKITLLIIVNLSLILIPVAKSQLQSGFYSSTCPKAEATVRSTVETHFKNDPTVAAALLRLHFHDCFVEGCDGSILIKGGSAEINAVPNLGLRGFEVIDDAKSQLESLCPGVVSCADILALAARDSVDLSSGPNWAVPTGRRDGRVSLASKASNLPSPLDSVDAQRQKFAAKGLDDRDLVTLAGAHTIGQTDCRFFRYRLYNFTTTGNSDPTLSQSTLTDFQKQCPRSSDGTERVALDKDSQLKFDVNYFKNVRDGNGVLESDQRLWGDPTTRDIVQKYAGTLRGLLGLRFDFEFKKSMVKMSSIEVKTGREFRSNVRQ... | 14 |
K3ZCE0 | 3.1.1.11 | ACT_SITE 276; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAVLAPLLLASLVSVATSSPPPSKDVQQASFAVNTPVKKPSHGGGQQASFVIGGDDGASSKVPPGSGAAGSFGEFIAENVQSYNVNKQIYAAKVKNGTGGKAVDAELSAAEAGAVRYVVSADGKGKFRTINDAIKAVPENNKKRVILDIRPGTYKEKVLVPYTKHFITFLGDPKQPPVIMWDDTAATRGKDGLPVGTVGSATVAVESDYFLASGIVFRNHAPMAAPGAKGGQAVALRVFGTKAAFYNCTIDGGQDTLYDHKGLHYFKGCLIKGSVDFIFGFGRSLYEDCSIVSVTKQVAVLTAQQRTRSIADAIESGFSF... | 125 |
B5YLL3 | 2.3.1.286 | ACT_SITE 51; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | IHILCIGNPNLHPSNLTSSNNNKFLHHIVTQNIDGLHRKTHLPRQHQSILHGCIFTEICDTCHTEHERSYEIDSIGLKYTGNVCTLGGSSGSGSCKGKLKDTLLDWEDALLDVDWTRAQEECEKADLIVCLGTSLRIEPAGSLCTFANPTKEGGGSGGGGGRSSKLGYAIVNLQQTPYDDGAALVIRAKVDDVMRGLMARLGYEDDWDDKFDYGKGAAVADNDDSDEEKKPASKKNGPVQSMSTSRLNLLPSLTNVDKGSRHEYEVSFGGAGLEKCRVKNLIVVPAVQYNVGDVILEE | 58 |
Q968Y9 | 2.7.10.1 | ACT_SITE 1388; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MTRMNIVRCRRRHKILENLEEENLGPSCSSTTSTTAATEALGTTTEDMRLKQQRSSSRATEHDIVDGNHHDDEHITMRRLRLVKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKKSSMTSLMLLLLFAFVQPCASIVEKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDLEIGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEY... | 97 |
Q54AK6 | 2.3.2.23 | ACT_SITE 97; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MSEHNSDIVHPPTKDCITRLKREFQEISKNPIENILVTPSPSNILEWHYVILGASNTPYEGGVYYGQLIFKYNYPLSPPSILMTTPSGRFETQKRLCLSISDYHPESWSPSWSTSSILLGLLSFMSDNEVTAGSIVTTNDEKRILATKSMDFNKKNKTFCELFPYLAMDE | 64 |
A0A804IK23 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDPKLVRLPPFILVSTFTLLLLPFLSPPVASQLSSGFYSSSCPDVELLVKNTVRSAYEIDSTIPAKLLRLLFHDCIVQGCDGSVLVEGNGTERSDPANKSLGGFYVVESAKRLLEFWCPGTVSCADILVLAARDAVELTGGPSVVVPLGRRDGAVSSAASVRPNMVDTTFTVDQLAQRFSSKGLSMDDLVILSGAHTIGSAHCTAFSDRFNQLSDGTMVPADASLERNYAMQLARKCPAGASDSVTTSNDPVTPSLFDNQYYGNLLAKKGLLQSDSVLVADARTKSTVEALSRSQDAFFASWAKSFVKLSTIGVKTGNEG... | 14 |
A0A067GNE7 | 5.3.1.8 | ACT_SITE 303; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MAENNNTEIKKRKRMINKPLRLQCAVKNYNWGIVGSKSHVSRLFCLNSGTHINPNEPYAEFWIGTHESGASFLDHGGLSLKEWISKNPDVLGDRVLNKWGGDLPFLFKVLSVEKALSIQAHPDKELARTLHKSQPSLYSDENHKPEMALALTEFEALCGFISLKELRNVLCTVPEIVDLVGGADAEQCFPVNEFGRSQEVKAIVESIFSQILLSSKDEICEIISRLKWRLNLEKKKRQLTDKEMLVLRLEGQYPDDAGVLAAFLLNYVKLNRGEALCIGANEPHAYIRGECIECMATSDNVVRAGLTSKHRDIQTLFSML... | 214 |
B7Q2V1 | 2.3.1.48 | ACT_SITE 344; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | VSFQPQVTEGCRMPVRMRNSNDWPLAEILSLKELGDNQFLYYVHFIDYNKRLDEWVTAERLDMKKLQLPRKENKTPLKDVKNGSRPCSPDPLAPLPAGVRPPPSFVARSSVCWPGTETAARRNVTADPQEITSSSPLPSCPVSQDSQDSLTPWPRPTGSMVAHHDDIVTRMKNIEMIELGRNRIRPWYFSPYPQELVNSCIYLCEFCLKYTKSRTCLKRHLAKCTLKHPPGNEIYRKGSYSFFEIDGRKNKMYAQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEVDSRGYHLVGYFSKEKESTEDYNVACILTLPPFQRK... | 61 |
A0A0A0L7Y3 | 2.7.1.11 | ACT_SITE 259; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MDSSFSSFSSSSTSIHFSAPASDHLPFWNRGSSPMDHNGGNSRGAPGDSLTGGDFHYVLEDVPHLTDYLPDLPANLNPLQDNPAYSAAKQYFVNVDDAVAQNVVVHNNSPRGTHFRRAGPRQKVLFESDEVHACIVTCGGLCPGLNTVIREIVCGLYRMYGVHRVVGIEGGYKGFYARNTIPLTPKSVNNIHKRGGTILGTSRGGHNTTKIVDSIQHRGINQVYILGGDGTQKGAAAIFEEIRRRGLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAISAAHVESESNENGIGLVKLMGRNSGFIAMYATLASRDV... | 84 |
Q759W4 | 3.4.21.89 | ACT_SITE 44; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367"; ACT_SITE 83; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367"; ACT_SITE 109; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P15367" | MNIRQQLTKFLGLFLTLASAFMFWKGLSVVTNSHSPIVVVLSGSMEPAFQRGDILFLWNRERFNKVGDVIVYEVDAKSIPIVHRVVREHRDKNGRQLLLTKGDNNAADDIALYGRKQSYLRRDKDIVGTVKGYLPKLGYVTILVSENQYAKFALMGMLALSSLLGSE | 178 |
Q89IK6 | 3.4.21.89 | ACT_SITE 51; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 112; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MTTLEQTIRPSAQSREWKAIVILVLLIPVLWSPPFLFRFFLYQPFNIPSNSMAPTLMVGDYVFAAKSAYGYDRYSFPYAPSWISGRFFAADPGYGDVVVFRTAKDASVDYVKRVVALPGDRVQMRGGQLVLNDRPVTRVALASVAGGAVCGTDDGTKIKRWRETLPNGASYVTYDCVDNGYLDNTSVYTVPPGHFFALGDNRDNSTDSRMMSAMGFVPMDHLVGKVTRIFWSLDADGRLRGERMGKVW | 178 |
A7ERM2 | 2.1.1.37 | ACT_SITE 740; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MPRSGNFSRDPSTSTDNSKLVHQQILAQQLDLDQTTSSDVDSTTPPLFQKRNISIYPPELIYPKSRYFGYIPPLPTSKEYQAYAVLSQEVNNQNLVRPPSTQEDFVEFELTDFSIYMPDTPLYGHEMRGLQDLASKASHSCLLFDRILSVGSLRHYVQGVPFKICSIGNYGEEVDDVDGAIWLQSDLNAKANIYYRLGKPTPEYSRFHLGFLWLSNLSKHFVDYSLACQEQKKKVSICNFRTEFAQWCRKVHAKSSKFQSWYLEYGRDDLRQTVSANINFLFKESIGVMEKLRSLDIWKEVLEKSSIKQHPIVENMTIVT... | 47 |
Q8GX23 | 2.7.11.1 | ACT_SITE 436; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MADSPVDSSPAPETSNGTPPSNGTSPSNESSPPTPPSSPPPSSISAPPPDISASFSPPPAPPTQETSPPTSPSSSPPVVANPSPQTPENPSPPAPEGSTPVTPPAPPQTPSNQSPERPTPPSPGANDDRNRTNGGNNNRDGSTPSPPSSGNRTSGDGGSPSPPRSISPPQNSGDSDSSSGNHPQANIGLIIGVLVGAGLLLLLAVCICICCNRKKKKKSPQVNHMHYYNNNPYGGAPSGNGGYYKGTPQDHVVNMAGQGGGNWGPQQPVSGPHSDASNLTGRTAIPSPQAATLGHNQSTFTYDELSIATEGFAQSNLLGQ... | 99 |
A0A8I6ADN0 | 2.3.2.26 | ACT_SITE 792; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MASASSSRAGVALPFEKSQLTLRVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEVIVLNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKRSQPPSRESSGTALAPETRHQPPSTNCFGGRSRTHRHSGGSARTATATGEQSPGARNRHRQPVKNPSSSGLANGTVSEEPTTASDPEELSVVGVTSPPAAASSVSPNPNTTSLPAPSTPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRQLPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYV... | 65 |
B9H303 | 5.3.1.8 | ACT_SITE 313; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | METGLEKNHHGGGGLKRLRCSVQNYDWGKKGTEGSEVARLYELNSGSDIELEKKKPFAEFWMGTHGSGPSFVVESGVENGDSIGSGSMGLKEWILKNPNVLGDGVLDKWGCDLPFLFKVLSVAKALSIQAHPDKELAKVLHKLQPNRYKDDNHKPEMALAITEFEALCGFISIGELKGVLRDVPEIVEVVGSAEANQVLQIHEQDHEEKVKSVLRSAFTQLMSASQEITAEAISKLKSRLYMESKIRQLTGKEQLVLQLEKQYPADIGVISAFFLNYVKLNSGEALYLGANEPHAYLYGECIECMATSDNVVRAGLTPKL... | 214 |
D6WV87 | 1.2.1.12 | ACT_SITE 161; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MVKIGINGFGRIGRLVVRRCFQKLRDARCSASGDSPQVVAVNDPYLSADHMANLLKYDSTHGLFQGEISVIGSSLKVDGQIVDITNEKNPEKIPWAKSCPKYVVDATGLYKSYDKASALIHDTVERVVLTYPSKDDIPMFVFGVNQDNYCNELKVVSNASCTTNCLAPLVKVIHDNFKIECGLMTTIHAITPSQNTLDGPAKKNYRIGRGALQNIIPTSTGAAKAIGKIIPEMDGKLTGIAARVPVADASMVDLTVVIDTPADYEVIKCKVKEAADGYLNGILAYTDDQIVSSDVIGDSRSSIFDAGAGVALTRNFIKLI... | 22 |
F6UF15 | 3.4.21.92 | ACT_SITE 247; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 272; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MLGILMQRPPPAGCVWHRGACQPRRARPRSKDFHTVRKPKQPRGERGAQPAQSGSSYETAEWSLFPEAGGVVSKRQGAKHAGSCSSAIGRKPGRPCDAMWAGVLVGGARVAAGRCPALGPRLAARFPPQRAPESGLVLRRSLHATAARALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTSGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYSIYAKHTKQSLQVIESAMER... | 179 |
A0A8V0XQ80 | 2.7.10.1 | ACT_SITE 829; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MAVCLLRLPVLVMTAMTFTSAMNQSTSEITCVFIRQRDGASRTEETSVSSKISNVLEDLECHLNSQGAENIYEPIKKVEANVFEDIELRIIMNISEIISCHCFFKEIQPCEPSLDSDNQYVTSLYFSQIRETQAGKYTFSVISKNSNYTIIVPVLIRSKPGKPYFRISEKLDVIECISESYPQPSVKWAFCRTPEKSCLNKMYEENGEIDGIQKVQYELHQSELFETYIWCCAANDLGRECTSLFTIDLSERRAAPSAELLLKVGEPLLIRCRAVYRNYKFRINVSFENKEVQQNCRFEGLEYQTDHSAIRTQYMFTPAA... | 97 |
P47280 | 2.7.1.21 | ACT_SITE 94; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MGKYQPSFQTKKGWTEVICGPMFSGKTEKLLHKIKRWKIAKISVVIFKPIIDTRQTNIVKSRNGEYDQAITINSPFEIYDHLVDKNYQIVAIDEAQFFSNEIIEVVTTLNEIGTNVIISGLDTDFRAEPFGCIPQLLAIADVVNKLDAICNVCGSLAQRTQRLVNKNTNDNLVLIGDAEAYEARCKLHHSFLTKKHVTVKTKNFKEQVQGKTQ | 88 |
Q5AY38 | 1.1.1.8 | ACT_SITE 264; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MAPTKKHQVSVIGSGNWGSTIGKILAENTSEHTDTFETPVRMWVFEEEITVPSDSPHHSKYGDKPQKLTQIINETHENVKYLPGIKLPDNLIATPDIKEAVKDASILVFNLPHQFIGKTLDQIKGHHLPYARGVSCIKGVDVSDGKVTLFSELIMQKLGIYCGALSGANIAPEVAAERLCETTIGYDPPPMDLTSSDGSPEDNLPHVDGQRQKDLSSTDIKLERVPQDYPHVNDELLEKMFERPYFLVHVIKDVAGVALGGALKNIVALAAGFVAGKQWGENTKAAIIRQGVGEMIRFGRTWFPSSVNEKTFTEESAGIA... | 7 |
Q6K968 | 2.7.11.1 | ACT_SITE 198; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNYYSCGASSTSSPTSPSLVDYYYCYHRYPSSCSSTSTATSSGGRMPIRSHQQRLSSPTAVLGHETPALREVYTVGRKLGQGQFGTTYLCTQVSTGAEYACKSIAKRKLLSPEDVEDVRREIQIMHHLAGHGSVVTIQGAYEDNLYVHIVMELCEGGELFDRIVERGYFSERKAAEITRVIVGVVEACHSLGVMHRDLKPENFLLKESSSSSSLKAIDFGLSVFFKPGQVFSDVVGSPYYVAPEVLCKHYGPEADVWTAGVIVYILLSGVPPFWAETQQGIFDAVLRGSLDFDSDPWPTISDSAKDLIRRMLRSPPRER... | 99 |
Q9FKA4 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297" | MGLVRSFALVIVFLSCLIAVYGQGTRIGFYSTTCPNAETIVRTTVASHFGSDPKVAPGLLRMHNHDCFVQGCDGSVLLSGPNSERTAGANVNLHGFEVIDDAKRQLEAACPGVVSCADILALAARDSVSLTNGQSWQVPTGRRDGRVSLASNVNNLPSPSDSLAIQQRKFSAFRLNTRDLVTLVGGGHTIGTAACGFITNRIFNSSGNTADPTMDQTFVPQLQRLCPQNGDGSARVDLDTGSGNTFDTSYFINLSRNRGILQSDHVLWTSPATRSIVQEFMAPRGNFNVQFARSMVKMSNIGVKTGTNGEIRRVCSAVN | 14 |
B9FKW9 | 2.7.11.1 | ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGNCCPPGSSSEPDPPPASSGSSRPAGSAGAAASPATISPSAAPAPAKPPAPIGPVLGRPMEDVKSIYTVGKELGRGQFGVTSLCTHKATGQRFACKTISKRKLSTKEDVEDVRREVQIMYHLAGQPGVVELKGAYEDKHAVHLVMELCAGGELFDRIIAKGHYTEHAASSLLRTIVEIIHTCHSMGVIHRDLKPENFLLLSKDEHAPLKATDFGLSVFFKEGEVFRDIVGSAYYIAPEVLKRSYGPEADIWSIGVMLYILLCGVPPFWAESEHGIFNSILRGHVDFSSEPWSRISHGAKDLVRRMLHSDPKQRISAYDV... | 99 |
A0A804IZ53 | 3.1.1.11 | ACT_SITE 391; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAPTTEPLLSSPATHTTRLPCKALLLTLSLATVVCLTAFMTIQLMTTTTTMNPPLQPSDLCAKSPNPTSCHAIVSQVMLTSAENHHPTPVQIFRSLLHNSLVQLDAAAASAADIHLRLLKEPKQQAALADCMQLLQLSRDRIVSSGDAAGTDARTWMSAVLTNHATCLDGLHGAAKSAMQAHLESLKASASASLAVLHAVPSSEHDNDDDIVKPVATFPSWLSHRDRKLLQMTSPNAVQANAVVAKDGSGTFKTVQAAVDSVPNGNKNRYVIYVKKGVYKENVSLGKKTTNVMIVGDGMDATVITGSLNVVDGSTTFDS... | 125 |
B4EZS7 | 1.3.3.3 | ACT_SITE 108; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MSLPDIHRVQSFFLSLQDSICHAIENIDQKATFQQDNWQREAGGGGRTRMLTQGAIFEQAGVNFSHVYGDALPASATAHRPELSGRRFQAMGVSLVIHPLNPYIPTSHANVRFFIAEKEGEDPVWWFGGGFDLTPYYGFEEDVIHWHKVAKSVCDPFSQDYYARYKKWCDDYFYLKHRNEPRGVGGLFFDDLNTPDFDHCFEFVQHVGQGYLDAYLPIVEKRKSIPWGERERQFQLYRRGRYVEFNLVWDRGTLFGLQSGGRTESILMSMPPLVRFAYDYRPEPNTPEAKLYTDFLIHKEWV | 27 |
A0A0R0KM06 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKMRFFLVACLAVFCILGVCQGGNLRKKFYKKTCPQAEEIVRTKIQEHVSARPDLPAKLIRMHFHDCFVRGCDGSVLLDSTATNTAEKDSIPNLSLAGFDVIDDIKEALEAKCPGTVSCADILALAARDTVSVKFNKPTWEVLTGRRDGTVSISGEALANLPAPFFNFTQLKESFASKGLTVHDLVVLSGAHTIGIGHCNLFSNRLFNFTGKGDQDPSLNPTYANFLKTKCQGLSDTTTTVEMDPNSSNTFDSDYYSILRQNKGLFQSDAALLTTKISRNIVNELVNQNKFFTEFGQSMKRMGAIEVLTGSAGEIRKKCS... | 14 |
Q54RR9 | 2.7.11.1 | ACT_SITE 1597; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKDNIPTGSIIIPLNHHPQQQQIPQQQEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEQQNNNNNINDNINGNNNSNEIKNTKDANITNNNGTSIIISLSPPPSPALNSSSSSTINSNNTTISGGDNENNNNNTNNTNNNINNSNNSNNNNSNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTNEEGNKTNINTTNNNSQNININNGINKNTRNNNNNNNNNNKQMTPPTFKNNLQVKHQPQSSSGGSIGGSNKLSLSKRVKSTTSSRASIIDSIDIDIVFNSLKNSITSKNSFVLGVHRHRMSSI... | 99 |
P24719 | 2.7.11.1 | ACT_SITE 290; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRPLYSCNLATKDDIEMAGGVAPAHLEVNVGGYNTEQTIPIVKHQLVKVGRNDKECQLVLTNPSISSVHCVFWCVFFDEDSIPMFYVKDCSLNGTYLNGLLLKRDKTYLLKHCDVIELSQGSEENDIKKTRLVFMINDDLQSSLDPKLLDQMGFLREVDQWEITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNS... | 99 |
Q74BH6 | 2.7.1.23 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MKKIAIFAKVHDPRCQGVASELIAWLEARGLIPLVEAHLARHLGGRQGIVPEDIPVLADMAVVLGGDGTLISAARLIGSRQIPILGVNLGSLGFLTEITLDELYPVLESCLSGDFQVTERMMLTVSVERNGEEICSHRVLNDVVINKGALARIIDMETEVSGIRLTTYKADGLIISTPTGSTGYSLSANGPIVHPSLECITITPICPHTLTNRPIVLESSSGVTVWLRSKDEDVYLTLDGQVGMELKCGDAVHVRRAAHRTRLVMSRSRNYFEVLRTKLKWGER | 89 |
A0A3N7HZV6 | 3.1.1.11 | ACT_SITE 130; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPSDNKNWVCIHVRAGTYREKVKIPYNKPYIILRGEGKRRTKIVWDDHFSTAQSPTFVSLADNIVVRSITFVNSYNFPHDNNPRLPAVAAMITGDKTAFYQCGFAGVQDTLWDEAGRHYFKRCTIQGAVDFIFGSGQSIYEGCSIQVLEGGFITAQGRTNPSDANGFVFKGCNVFGKSSVYLGRPWRGYSRVLFYKSNFSNIVDPEGWNAWNFVGHENHITFAEYGNFGPGAEISKRVSWANKLSPQSLEELTSMSFINAENWIEKQPI | 125 |
P36583 | 2.7.11.13 | ACT_SITE 808; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDMIDEAITEVVRKIERERSVIHGALSMKRLTQNQTVHQQLHSNIEESKKSIIYLEERLEKLKLRKNGVRKSNSEKPSVGIEKNPSFSTTKSAKSFSSTSSNIDSNLDLLNYDTPLTISKISFLLQQLEFKLSVEEQYRKGIEKMAKLYEREHDRRSIAEAEKKYVESAQKITLLKQALKRYHDLHIEIDEEDVPSTESRGNLNARRPQSGLLKITVGSLRNVTHSAGISKQTEMIVAIRAEDLERARTRPSRTDRFNETFEIDLEKTNEVEIVVYEKKNEKLLLPVGLLWIRLSDLVEKQRRKKVEQEVSDKGWVSADK... | 100 |
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