Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A8M2BEF6 | 2.1.1.37 | ACT_SITE 1298; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFESQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFEARDGQEIVPVDDVMKSPKALKSSYESGRAGEESDMEINGGRRSATYDPKWQRNLKWIRASDMGDNYAYCTTCDYNIILLAGFHDLKRHQLTQNHMKHETGRTNLPGRKQIEESISCSETMLLFIQSHCLSSLPSRINRVSQRTARCILGLKYPNDIVSACKLNPYCIYIYGQVPLDVKTGDKTNCHVVLA... | 47 |
A0A251QMM0 | 3.1.1.11 | ACT_SITE 364; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATKPSLLLSILIFSFIFQTALSRSHHHSSRIRTWCQKTPHPEPCNYCMSHSRHRLVPKHTSEFRKMMVQVALERALNAKSYASQFGQNCQNNQQKAAWADCLKLFEDTVHQLNITLEGLGTKRNCSNFDAQTWLSAALTNIHTCQVGSMELNVSDFIAPIYTSNNNVSELISNGLAIGSQLLGTEENYADEEYPNWVSKHERRLLQASKIKANLVVAKDGSGHFRTVQAAIDAAAKRKITSRFIIHVKKGVYRENIEVSNTNNNIMLIGASMRYTIITASRSVNGGSTTYNSATAGIDGPGFIARGITFSNTAGPLKGQ... | 125 |
A5I348 | 1.8.4.11 | ACT_SITE 10; /evidence="ECO:0000255|HAMAP-Rule:MF_01401" | MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPTVLNKQGNDRGTQYRTGIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD | 39 |
B9TH96 | 5.1.3.3 | ACT_SITE 153; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 287; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MEIRIMTYGGTLLSLRVPDRDGRLADVVLGFDSLAPYLGEHPYLGGIIGRYANRIAGGSFSLDGRIYQLTQNEGPNHLHGGTLGFHRQLWRALPQKTRNADQLVLHYLSRDGEEGYPGDLHVEVIYTLTARNELRVDYHAQVDRPTIINLTHHAYFNLGGGDTILDHVLTLTADRYLPVDGLLIPTGELAPVADTPMDFRTPTPIGSRIHEQDAQLLRASGGYDHCWALNSDTGILAAELYDSFSGRKLHVYTTQPGVQFYSGNFFDGSVVGKEGHAYGKYAGLCLEPQHFPDSPNQPDFPSTVLGPHDFYQHSTIYAFD... | 211 |
H2LM09 | 2.7.11.1 | ACT_SITE 292; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MDPSPSLKVTKSVKLQKPEIKQVNDGPRRIPVSQQHQMVPKAIVTPTSHQRVLSVSNGPQRIQRPVSHQKPVSQVAFTNKSSHSGDQNVNPATLNAHHAPPSKPTSQQNQPKTQVLGANPDLAKPPSEPIKADNTDYFLSCMYKPENVLWKAVTRLLCSYRKRWSLEDFDIGRPLGKGKFGNVYLARERQTKFILALKVLFKKQLERAGVEHQLRREVEIQSHLRHPNILRLYGYFHDASRVYLILEFAPKGELYGELQRCGSFPEDRSATYIMELADALHYCHTKKVIHRDIKPENLLLGANGELKIADFGWSVHTPSS... | 99 |
Q9VU29 | 1.1.1.37 | ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MFLASRLLSHVGNLPPKVQQLGYINRGLKVAVVGSVGGIGQPLSLLLKHNPQISTLSLYDIKNTTGVGVDLSHINTRASVCPFEGKNGLKKAMDKADIVVIPAGLPRKPGMKREDLVDVNASVACEVAFAASEVCPGAMLAFITNPINVIVPIVATILKAKGTYDPNRLFGVTTLDVVRAQTFVADILNVDPQKVNIPVIGGHTGRTILPILSQCDPPFKGTDKEREALIQRIQNAGTEVVNAKDGLGSATLSMAFAATQFVSSLIKGIKGSKDECIVECAYVESDVTEAQFFATPLILGPQGVKENTGLPDLDDEERKA... | 5 |
B9RI07 | 1.11.1.7 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MADFIIKRRRFFAVMLIIPVLLSLRNPKVDQMEDINFSVFLQRDEIIRTYSTADIHDLEYDFYRQTCPQAESIVRSRMASIYSQHNDVSAGLLRLFFHDCFIKGCDASVFLDDSNGNSNRSIEKQAIPNRTLKGLDKIDMIKKDLENACPGVVSCADTLALATRDGVVLAGGPFYPVFTGRRDSTQSYFQEAMAEIPKPNGNISETLDLFALRGFNERETVSLLGAHNVGRIGCDFIQGRLDNFEGTGQPDPSMPSDFVNEMRLNCQDNSSIVHDEAPVPMMSREVKNPTNGLMFSQGLSTSVSSGTGFDAHYYRNLLRG... | 14 |
H2LKP1 | 2.7.10.1 | ACT_SITE 599; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MSAYQPGSWALSGSESWRCLLWWWFLSWGLAVGSGDPWMSAEACRSSCSCSSTRISCVDPETGISSFPSLQKPESEKFQAGIWIQPVVYVAQCFVWFLLNVYVCSSILSGNPLRCSCENMWIKLLLGEEADIQELRCTEDGGARKLLSRLTLPNCGKCICNHTHATSEGEKHSQGLSCTTSGVPAPELNWSMIETSGQISVLRLSNLSSLDHNSKISCIAENIVGEKESSLQLDILFPPKITKLSDAIPDHHWCIPFSVAGNPVPHFQWYLNENEVTEGAYIMTMIHDITEREYHGCLQLDNPTHLNNGRYRLVVTNEYG... | 97 |
Q8ZY26 | 6.3.4.4 | ACT_SITE 12; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00011" | MLYVVVDGFFGDTGKGKITAYLAMADKPELCVRTGAPNAGHTVVWNGEVTVLRSLPTCFVNPGSKLAVAPGALIKIDVFLSEVKQFGKGRSYVDYNTGVIEDVHLERERRDEFLMKTVGSTGQGVGAAMVDRVLRRLRLAREFEELKPYLADVPAMIHEHREGGVVIEGTQGTFLSLYHGTYPYVTSRDVTASGVLSEAGVGPKAVDHVVLVFKAYVTRVGNGPLPGELSPEEAERRGWAERGAVTGRPRRAAPFNMELAKRAVLLNTPTQIAITKIDVLFKDASGKTKWADLPPEARRWIEEVEEALGVPVTLIGTGPE... | 253 |
A0A6I8NDD2 | 2.7.11.13 | ACT_SITE 531; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MGSCQMPHGPDGINTAGMGTSRAVRLCLDNVLTRGCLLIPSRATDPQVSSQLVTQSAMAPFLRISFNSYDLGSLITSEEQCQPFCAVKMKEALTTDRGKTLIQKRPTMYPEWNSSFDAHIYEGRVIQIVLMKAAEEILSEATVGVSVLAEKCKKSSGKTEFWLDLQPQAKLLMAVQYFLEDKDKDDSDRTMNRRGAIKQAKIRYIKNHEFIATFFGQPTFCSVCRDFVWGLNKQGYKCRECNAAIHKKCIDKIIGRCTGTAANSRDTKFQKERFKIDMPHRFKMNNYMSPTFCDHCGSLLWGLVKQGLKCEECGMNVHHK... | 100 |
Q9KUB0 | 3.2.1.52 | ACT_SITE 433; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MSYRIEFAVLSEQKPDCRFGLTLHNLSDQDLHDWSLYFVIDRYIQPMSVTNGQLTQVGSLCSIVPTEKVLQANGHFYCEFIIKTAPYHFYTDGVKHAFVQLNDKQPVERINVAVNPIVLASPFRERSQIPEVTAAELCLIPKPNSLQRFQGEFVVNHSSQISLQSDSAARAARWLEQELHALHEFKLNTVGHSDIVYRSNPTLDEGHYQLNIEAQGIKIEAGSHSGFMHASATLLQLAQAHQGSLRFPLVNIVDAPRFKYRGMMLDCARHFHSLEQVKRVINQLAHYKFNVFHWHLTDDEGWRIEIKRLPQLTDIGAWRG... | 170 |
A0A194YPA5 | 3.1.1.11 | ACT_SITE 392; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDHHLLARRLGAPPVLLLILSCLALILAGCSCSCSSAHAASAPRPPVFAFPAAAAKAKAQHAVARHHESRLRAALDAAATRVGEALGALAATSSPTLAAAAAREDCAELLDEALQLLAGARAAARGDALTWLSAALTNHDTCADSLAEAGAPLHAHAHLAAARAVVRDSLATMYASSTTTTAATATGTTEDAGGAAGLVRSCCNKNETTTRRQGGPCRFPRWVPARDRRLLLAPAASLAGTADIVVAKDGTGTHATIADAVKAAPECSERRTVIYVKAGRYDENVKVGMNKTNLVFVGDGKGVTVVAGNRSVADNYTTFR... | 125 |
A0A8M6YUX4 | 2.1.1.37 | ACT_SITE 1115; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MPTKTSLSLPEDVKERLQVLDEGGDSLSDEECVKEKLRLLQEFLLADTQDQLKNLEDKLKSSELSTEVYMSEVKAVLKKALGVVKEGDGVEQNGHSNGFSENGSHKDNGEQEGAMDTQEEGDAIKSPSAPKGRGGRRSKADSEPKKSPASSRVTRNTGKQQTIVSMFSRVPKRKSDELNGEPANGDTEIKTEETITEEVREEKRLKTEDEKPEAENAANLKPVSTAKTPPPKCPDCRQYLDDSDLKFFQGDPDDALDEPEMLTDERLSLFDSNEDGFESYEDLPQHKITNFSVYDKRGHLCPFDSGLIEKNVELYFSCAV... | 47 |
P08458 | 2.7.11.1 | ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MESKEISIRSRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVKNITITNLKSDVDLIKQKKVQERYTKVPKYPLQNRLYKNSNTVRGKEF... | 99 |
Q4QE49 | 3.4.19.12 | ACT_SITE 78; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 81; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR013503-1"; ACT_SITE 261; /evidence="ECO:0000256|PIRSR:PIRSR013503-1" | MDEGLPIDASEAQLEAIRREVAQYPLLSLSLPLNKESMIVKEMEHDDAYLAQTLSLFGASPVSTKQYDFGSIRYSRRDGNCFYRCAGFRLCELIVEHPERAAEYVALLKSREESLSRLFGLFVFDFTDALAEILKGVADKTITSVAQVYNRFISDDAAYVLAALRYLISAYLQEHEEEYEPFVSGLGYGAVRDYCNAEVELVDHESDNVQLAAFAKAFNVCIKVYALDRNAGNNITEYSFNGEDNDAGDRLVVGLLYMPGHYNLLGRGPG | 175 |
A0A059CJ54 | 2.2.1.1 | ACT_SITE 500; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MASASSLTVSQAVLARSASAPRGGAGQSPSSDRLSVPSPRLPTFSGLKSSPAAAAAAGSAHRRLRRLAVPRPIRATAAVETLGPSAAAETALVDKSVNTIRFLAIDSVEKANSGHPGLPMGCAPIGHVLYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDSVKEEDLKSFRQWGSKTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDNEIVDHYTYAVLGDGCQMEGIANEACSLAGHWGLGKLIAFYDDNHISIDGNTEIAFTENVEKRFEGLGWHVIWVKNGNTGYDEIRAAIK... | 51 |
Q2FY67 | 3.1.26.11 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01818" | MEVTFFGTSAGLPTKERNTQAIALNLEPYSNSIWLFDVGEGTQHQILHHAIKLGKVTHIFITHMHGDHIFGLPGLLSSRSFQGGEQKPLTLVGPKGIKAYVEMSMNLSESHLNYPITYIEIDDHLTYHHDGFTVEAHLLNHGIPSYGYRVMAPETTGTINVEALKNIGLEPGPKYQEVKSHDTFEHNGQVYQSKDFRGESKQGPVVAIFGDTKPCSNERVISRDADVMVHEATYIDGEKHLANNYHHSHIEDVFALIKEANVKRTLITHLSNRYNTEDINEIYQTLIQNEDTPNFNFVKDFDSFKI | 137 |
A0A2K1IF39 | 2.3.2.26 | ACT_SITE 478; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MVGVDQAVGGDSGLHPVCMLLWAWVTTMTMLLSFSVCAWHRRRMQRMREAGDLAAAIRLSMNDNQQQIVVNIPPGAIPAPIVRIDSSRTQDARVSPAADVPSIKIIHELKDSLSIGSLFKMKRDWLARELSKGKDGSKGKPSPARHERRLLQIVVRRDHVFQDSYLQFASLSDDDLRNPLSIHFVGEVGRDDGGVTRDWYSVLAKEIFNPQYALFTHSAVDDYTFQINPNSGINPDHLDFFRFIGTIVGKALYDGCLFVAHFTRFVYKQILDEPVTYHDMASVDVQFYESLCWLLQNKLEGMDLGLTFSVDTDNFGSYEE... | 65 |
Q76K58 | 3.1.3.48 | ACT_SITE 472; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002006-1"; ACT_SITE 762; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR002006-1" | MRNSLVQGRMGLCPLLLLLGVAVWASAQDQTPVTGPPSVTVKSTDPPAAPSVNLTVSAKLTSASPPTTLPPVVVLPTTAVTTADTTTAPSSAEEHDAKNPNGDAAVRVLPISEAPPSDSIEASPATPTIQPTSPPITEVNNVSTATTEDSSWIDTERTVTTTEVNVLTSHSPPEDESGDMPIIAVMVALSSLLVIIFIIIILYMLRFKKYKQDGSHLNSFRLSNGRSDETEFQSVPLLARSPSTNRKYPPIPVDKLEEEMNRRMADDNKLFREEFNALPNCPIQATCDAASKEENKEKNRYVNILPYDHSRVHLLSLEGV... | 149 |
B3S9G7 | 4.1.1.17 | ACT_SITE 328; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MPYVKFKNEDDPFYLVDISDLICKYKTWMSLLPRIRPFYAMKCNPNFQMVATLCRLGAGLDVASAGEIETAVALGLKGEDVIYSNTCKGISHLKVAANEGITQMTFDSEEELHRIKRILPNARLLLRLLVDDSGAQWKHGIKAGAPFSRVSHLFKVAKKLGLNLVGTSFHVGSDCGDPSAYSKAIERCRKAFDIAVSLGMELSMLDIGGGYPGHADTLFKNVGATSINEAIDIHFPSGCGVKIISEPGKYFAMSSSILCANIIGKRLRYEDGDVQIEGVKALEVMYHISEGMGGSFLSVIATHQQYIPKKLSNNNEKCYR... | 195 |
M1AYE6 | 1.11.1.7 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MFSKNWALMAVFSFLVICLVTTMAAHAEVDPGSASGFPFLLRYGYYDDKCEDLEDIVWSKMKTIVQLQHNAPAQLLRLMFHDCFIGGCDASVLLADRNENGTVEREAIPNRTLKGFNFIDTIKDEIEEECPGVVSCSDILVLATRDGIVLAGGPYYPVLTGRRDSKESFFDKAMAEIPQPNGNIIETLRLFSLRGFDERETVALLELRRKCPDDNNTISNMLNDEHTDTARGLSVSIATSLDNHYYKTLMRGRGLLFADQQLMANEKTAAAVTDYAIDDGIIFRTEFAHAMGKLSNFGVLTGSEGEVRHSCSHLNS | 14 |
Q9FIZ3 | 2.7.11.1 | ACT_SITE 1079; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MQQNSVLLALFFLCFSSGLGSGQPGQRDDLQTLLELKNSFITNPKEEDVLRDWNSGSPSYCNWTGVTCGGREIIGLNLSGLGLTGSISPSIGRFNNLIHIDLSSNRLVGPIPTTLSNLSSSLESLHLFSNLLSGDIPSQLGSLVNLKSLKLGDNELNGTIPETFGNLVNLQMLALASCRLTGLIPSRFGRLVQLQTLILQDNELEGPIPAEIGNCTSLALFAAAFNRLNGSLPAELNRLKNLQTLNLGDNSFSGEIPSQLGDLVSIQYLNLIGNQLQGLIPKRLTELANLQTLDLSSNNLTGVIHEEFWRMNQLEFLVLA... | 99 |
Q7KRY6 | 2.7.11.1 | ACT_SITE 183; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPRVAKPKAAAPAKKVVSAKKAKSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGDFKPDPKKMHNGTIEYTSRDAHLGVPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPD... | 99 |
A0A0A0LAE1 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAKTHFSFLLLLVLFQLFNSGRGQLQLNYYAKSCPKAEEIIKQQVIDLYYEHGNTAVSWLRNLFHDCIVKSCDASLLLETVVGVESEKDSSRSFGMRNFKYVNKIKAAVEKECPLTVSCADIVALSARDGIVMLKGPHIDLKTGRKDSKMSYSNMVEELVPQHNASLVNVLSRFNSIGIDTEATVALLGSHSVGRVHCVNLVERLYPTVDPTIDPEYAKYLKMRCPTPTPDPNGVLYSRNDRETTMILDNMYYSNVLKHKGLLIVDQELVSNPLTLPYVKKFAADNLYFHAQFSRGIRLLSENNPLTGDQGEVRKDCRF... | 14 |
Q64434 | 2.7.10.2 | ACT_SITE 312; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MVSWDKAHLGPKYVGLWDFKARTDEELSFQAGDLLHVTKKEELWWWATLLDAEGKALAEGYVPHNYLAEKETVESEPWFFGCISRSEAMHRLQAEDNSKGAFLIRVSQKPGADYVLSVRDAQAVRHYRIWKNNEGRLHLNEAVSFSNLSELVDYHKTQSLSHGLQLSMPCWKHKTEPLPHWDDWERPREEFTLCKKLGAGYFGEVFEALWKGQVHVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLV... | 98 |
P44427 | 1.1.1.37 | ACT_SITE 177; /note="Proton acceptor"; /evidence="ECO:0000250" | MKVAVLGAAGGIGQALALLLKLQLPAGTDLSLYDIAPVTPGVAVDVSHIPTAVNVKGFSGEDPTPALEGADVVLISAGVARKPGMDRSDLFNINAGIVRGLIEKVAVTCPKACVGIITNPVNTTVAIAAEVLKKAGVYDKRKLFGVTTLDVLRSETFVAELKGLNVSRTSVPVIGGHSGVTILPLLSQVQYAKWNEDEIEPLTKRIQNAGTEVLNAKAGGGSATLSMAQAAARFARSLVKGLSGETVVECTYVEGDGKYARFFSQPVRLGKEGVEEILPIGPLSNFEQQALENMLPTLRADIELGEKFING | 5 |
P92199 | 2.7.11.1 | ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEQDELRDQLVDPKSPINIESLLDTITALVNDCKIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNS... | 99 |
Q5VSJ4 | 2.7.10.1 | ACT_SITE 776; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MVCTSVSCVWIIFCLHLCFYVNTGIAQNTREVILLDSKAQQTELEWISSPPSGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWIEKGDAQRIFVELKFTLRDCNSLPGVVGSCKETFNLYYQETDVEVGRNIRESQYVKIDTIAADESFTQGDLGERKMKLNTEVRIIGPLSRRGFYLAFQDVGACIALVSVKVYYKKCWSIIENLATFPDTVTGSEFSSLVEVEGTCVNDAEEEADNSPKMHCSAEGEWLVPIGKCICKAGFHQKGDACEPCGRGFYKSSSQDLQCSRCPAHSYNDREGSWRCDCEDGYYRALS... | 97 |
Q8F528 | 1.11.1.6 | ACT_SITE 54; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 127; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MSRKTLTTAGGHPVSQNQHSLTAGPRGPVLIQDTHLIEKLAHFNRERIPERVVHAKGAGAYGTLTITQDLTKYSRASIFSKKGKQTSLFLRFSTVAGEKGSADTERDPRGFAVKFYTDEGIWDLVGNNTPVFFARDPLKFPDFIHSQKRDPVTGYKNPIRMWDYWAGSPEAFHQITILFGDRGIPDGYRFMNGYGSHTFGLWNSKGERFWTKFHFKSMQGIRNLSMEKASALAGTDPDYATRDLFEAIERKEFPKWKFCVQIMPEKEATKYKFNPFDLTKVWSHKDYPLIEVGVLELNSNPKNYFEEVEQAAFSPSNMPP... | 13 |
Q89WE4 | 4.2.1.20 | ACT_SITE 50; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MTTRIDIRFAELAKQGRSAFVTFLMAGDPDPATSLEIIKALPKSGADVIEIGMPFTDPMADGPSIQAAGLRALKAGMTLKKTLELVRGFRKDDNATPIVLMGYYNPIYIYGVDKFLVDAKSAGVDGLIIVDLPPEEDDELCLPAMKAGLNFIRLATPTTDDKRLPAVLANTSGFVYYVSITGITGAAAADSSAVSEAVARIKRHTKLPVCVGFGIRTPETARAIASHANGAVVGTALVDALKNSLDADGRATAKTVNAVAELTASLAQGVKGAQQAAE | 202 |
Q11186 | 3.1.1.3 | ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MTMINSRPELMNLSFSGCGFLCVYHAGVAAAIKEYAPELLQNKILGASAGSIVACGLITGVCISHATSTILKVVSQARSRTFGPLHPEFNLLGIVRDELEVILPPNAYEMCTGRLVISLTRWSDHENVIIDEYRSNADLIDAIMCSCFIPLYCGITPPKFRGVQYIDGGVSDNQPIYDEHTVTVSPFSGESDICPPDWDSGSMLGVDFNGTSIRFTTRNMFRLMACLWPRSTDDLSRMCLQGFGDALRFLTKCGLAPCIRCLTIQTIDANEPAGRVSSECFSENDDAKKVTHVAVPRMKKRASANALNSFRTRGESECET... | 128 |
A0A804L485 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGCVSRSCWIVFIAVLAMASSTSASLHLGFYRKTCPSAEAIVRRTVSEAVANNPGLAAGLIRMHFHDCFVRGCDASLLLNSSPGNTAEKDAPPNNPSMRGFEVIDAAKAAVEARCPSTVSCADIIAFAARDSAYLAGGIDYPVPAGRRDGRVSLDSEALTNIPLPNLTAAGLRDSFAKKGLSVDEMVTLSGAHSIGRAHCTAFAPRLYNFNATHTQDPSMDPAFAAYLKSRCSPSTVDFTSKDPTTVPLDAVTPRRLDNQYYKNLAKRRGLLFSDQTLQASRLTARLVRLDAKLGSVWAAKFAAAMVRMGHIEVLTGSQG... | 14 |
H3G8M9 | 3.5.1.98 | ACT_SITE 185; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MQHSFPAPSPSPKSENRSPMSSANGSSVALTSGGTVASKRRVAYFYDCTVQYLRPLRQFVTEIGNYHYGQNHPMKPHRVRMAHNLITNYGLTKHMEVFRPRLVDWTELTRFHSDDYIHFLRLVTPDNMHEYLRQLQRFNVGEDCPVFDGLFEFCQLYASASIGGAAKLNAGSADIVINYSGGLHHGKRSEASGFCYVNDCVLGILELLKTHQRVLYIDIDIHHGDGVEEAFYTTNRVMTCSFHKYGEFFPGTGDIKDVGHGDGKHYAVNFPCRDGMDDESFTGIFRSVIAKVMEHFAPGAVLLQCGTDSLSGDRLGSFNL... | 184 |
Q93571 | 2.3.2.23 | ACT_SITE 315; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MACLRKLKEDIQVLEKLFPKNHNRFQILSASVDELSMKFINAENKGIIVTANIQENYPRQPPIWFSESDDVPVIGMSLQRLTETEESTNILHQVHRLVSDLCSFYNLQMPCELPQIAPPVRDDIDEGRGSDISDTTSEPIDDDMAGDGEVDDDDEEEEDDEDADGDIEIVEMAEEDPTSQHDVGVSKEGLDMLDKVSKINRQQHLDGKVQGSITATDRLMKEIRDIHRSEHFKNGIYTFELEKEENLYQWWIKLHKVDEDSPLFEDMKKLKKDHNQDHLLFSFTFNEKFPCDPPFVRVVAPHINQGFVLGGGAICMELLT... | 64 |
Q5B6C6 | 3.2.1.21 | ACT_SITE 285; /evidence="ECO:0000250" | MAHRWLILALVAAAAPRALASPGPSLNERQSDDEPFSPPYYPAPNGGWVSTWAEAYEKAHSIVSNLTLAEKVNLTTGTGIFMGPCAGQTGSVPRLGIPNLCLHDSPLGVRNTDHNTAFPPGITVGATFDKSLMYERGVGLGEEARGKGVNVLLGPSVGPLGRKPRGGRNWEGFGFDPVLQGIGGAETIKGMQSTGLIACIKHFVGNEQEMHRMSSVVTQGYSSNIDDRTLHELYIWPFAEGVRAEVGSVMIAYNDVNKSSCSQNSKLINGVLKDELGFQGFVVTDWLAHYGGVSSALAGLDMDMPGDGAVPLFGNSYWGP... | 161 |
A0A022QF11 | 3.1.1.11 | ACT_SITE 132; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVNLDRVVINVHAGIYTEKVTIPPTKSYITIQGAGAENTVVQWGDMAKNTNGTFYSATFAVNSPFFIARNITFKNTAPVPPPGAKDMQAVALRISADAATFVGCKFLGAQDTLFDHEGRHYYKDCYIQGSIDFIFGDGRSFFENCELHSIPPGGALTAQHRDSESDDSGFVFVNCRVTGSAAVYLGRAWGSYSRVVFAYTYMHSIIIPRGWHDWGRKSRDSTVFYGQYKCSGPGAKFAKRVEWAKELTDEEARPFIYPDFVDASQWLNI | 125 |
A0A022QNJ5 | 3.1.1.11 | ACT_SITE 449; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQKQLIIHKDNTIYLFIVSTTFSGLFFFHTDTSMENMQSENKPKSRRKFILLSALSSLLLVAVVSVAAVQSHKHASIHGAGVAKYSVSHYSVVKSTCSVTLYPELCIWTIQEAAPAASMKSSRDVLITALNYTIYTVERNYFTVKKVGSTRSKSLTAREKGALHDCLEVIDDTLEELRDTEMELKDYGYKNYTIADHKEKIMSLLSAAQTNQESCLDGFSHYNADKVVRKVLLAGQKHVFKLVSNVLAIIKNLADTEMAQLNSSPAAEGRRLGEESSGEWPEWMSAGDRRLLQSSTVTPDVTVAADGSGNFRTIAAAVAA... | 125 |
A0A8J0SG86 | 2.7.10.1 | ACT_SITE 634; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MSKAGGGCGIALYQGIHMGMVTLFCTLCLFLVAVNCVPAARLPVTLPGEDRASRKASDYITVEQPPFDELMFTIGETIELSCAAEDASTTTKWFKDGIAIVPNNRTNTRQGLLKIINISYDDSGIYSCRLWHSTEILRNFTIRVTDLPSSGDDEDDDDEETEDREPPRWTQPEKMDKKLTAVPAANTIRFRCPAAGNPTPTIHWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDKGNYTCVVENKYGSIRQTYQLDVLERSSHRPILQAGLPANQTVVIGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKYGPDGDP... | 97 |
P96744 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MRIPLIAGNWKMYKTVGEATTLVRDLLAGLGELSDREAIVCPPFTALAAVAALVADSPLGLGAQNLYPEAQGAFTGEVSPPMLVDIGCRYVIIGHSERRQYFGESDAFVNRKLRAALAHGLRPIVCVGESKPQRDAGQAEPIVTAQVRAALLEVPPDQMANVVIAYEPIWAIGTGDTATPADAQAMHAAIRATLAELYGSEIAATVRIQYGGSVKPDNIDELMAQPDIDGALVGGASLQAASFLRIIHYQ | 213 |
A0A287BDL0 | 2.3.2.26 | ACT_SITE 2008; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSHLGQAKHKGYSPPESRKSNSKAPKVQSNTTSELSRGHLSKRSCSSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQQQLKSAQSPSTSKAHTRKSGAAAASRSQKRKRTESSCIKSGSVSESTGAEERSAKPTKLASKSAASAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKL... | 65 |
A0A2G2ZEU3 | 3.1.1.11 | ACT_SITE 355; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVLHKGAKDDAEQSPKVQMKASIEEFCKPAEFQMACFKSLDSVAKNNSATIKDYLLASLQVTGIEIKKSLGLVEKSNPIDNKTDPYNHMAVEDCKELLQYAVEELQDSYSMVGDTELRSLGDRGSELLNWLGAVYSYQSMCLDGIIGKPDYKETLENGMQNATQLTHNAINIIAKISTVHLPAFNDSTSTTTASISNATKNHRRRLLGYPTWFRVADRKLLAGGRHNRVPHAVVAKDGSGRRSLPILIIIEKQPNVFIYGDGAGKTIITGHRNFGIMKIPTQDTATFAVIGNGFIAMGITFRNTAGPQGHQAVALRINGD... | 125 |
A0A3B6B862 | 1.11.1.7 | ACT_SITE 98; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTPTACREEATSPLNSSSSFTSAPQMASSSLVVLAAMATVAALLLSPATSLPVFTGDASPGFHAASCPQLDGIVWSSVEAALRQEVAVAAGLLRLYFHDCFPQGCDASILLNNTAARETALGPNLTIQPRAMQLIESIRARAHAVCGPVVSCADITLLATRDIIVISGGPWFNVPQGNLDSLAPAAQEKVFDLPAPKTASVATLVESFATRGLGDVADLVALSGAHTIGRSQCGSFEDRSQRADDTFSRKLAANCSKHPERLQNLDVITPDLFDNAYYKALGFNQGVFTSDMALVKNKTTAAIVKRFAESKDAFFGQFAR... | 14 |
G7LB60 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAINIMVTLFLSLILLFSIVSTGNSLSYNYYEKTCPDVEFIVAKTVKAATASDKTVPAALLRMHFHDCFIRGCDASVLLNSKGSNKAEKDGPPNASLHAFFIIDNAKKALEAACPGVVSCADILAFAARDAVFLSGGPSWDIPKGRKDGRISKASETIQLPSPSFNISQLQKSFSQRGLSMEDLVALSGGHTLGFSHCSSFRNRIHNFDATHDVDPSLNPSFASKLKSICPIINQVKNAGTTLDASSTTFDNTYYKLILQRKGIFSSDQVLIDTPYTKDLVSKFATSQDEFYKAFVKSMVKMSSINGGQEIRKDCRVVN | 14 |
A0A067EF61 | 3.1.1.11 | ACT_SITE 409; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | VDEADLHARLEARRRTRRRIAIVSLSSIVLVAVIVAAVVGITRNNDSDRVEAENNGHGRVISAAIKAVCDVSMYKDTCYDSLSKGASNSSQMQPEELFKLAIKVASNELSKASDKFFSDHNGTSDDNNNNNIMFLDALGNCRELLSIAWDSLDSSLSSGKSVSDAVNDLKTMLSSAGTYQETCIDGLEEAKPGFRARVLEYLRNSTEMTSNALAILTGISKVESSLKLRRLLGEPPHEWLRPEDRKLLQSPAENWKKNANAVVGKDRFAKYKTINDALRAVPDKSKKKFIIYVKKGVYVENVRIEKPKWNVVMIGDGMNE... | 125 |
H3G9Y3 | 2.7.11.23 | ACT_SITE 126; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MERYDRGDVLGEGTFGIVFAAVQKSTGRRVAIKQFKRGKFKDGVDFTALREVKLQAELKHVNVVELLDVFVANDTMNVVFELLPSNLDDVIKDKAVVLTAADIKTYMQMLLKGLAYCHAHYVLHRDLKPENLLIGPDGNVKIGDFGLARVYGSPNRNMTSMVCTIWYRPPELLFGAREYSGSVDMWGAGCIFAELMLRMPYLTGLNELDQLGKIFHALGTPTDDEWPGVSSLANFVEFTPSTAPPLASIFSAASEDALDLLAKLLKYNPAERITAADALKHPYFSNSPAPTPTEKLPSTPAQPQT | 103 |
P94377 | 1.11.1.6 | ACT_SITE 83; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 161; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVTDNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDEPISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVGNNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGIPANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQDLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDD... | 13 |
B8DZU8 | 1.1.1.205 | ACT_SITE 308; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 404; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01964, ECO:0000256|PIRSR:PIRSR000130-1" | MNFDERFLGEALTFDDILLVPAYSEVTPREVSVDTYLTDRIHLNIPILSAAMDTVTEARMAIAIAREGGLGIIHRNMSIERQAEEVDKVKRSEHGMITDPIFLYPDQTVGEALSIMAKYHISGLPVVERDGKLVGIVTNRDLRFESDMNKKVSEIMTKDNLIVAQVGITIKDAQEILQRYKIEKLPIVDKDFKLKGLITIKDIQKMRQYPNAAKDKKGRLLAGAAIGVGDEAIRRAKALVEAEVDVIVIDTAHGHHKKVLETVKELKKLFSKEVVIVAGNVATAEGTKALIDAGADVVKVGIGPGSICTTRVVAGIGVPQ... | 3 |
A0A2K1KPB8 | 1.1.1.37 | ACT_SITE 208; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MAARFAAAGLLKRALSSAPQQQVRCMSSQTPKRKVAVLGAAGGIGQPLGLLMKLNPLVTDLSLYDIAGTPGVASDLSHINTGANVEGFAGEQELAKALKGCDLVIIPAGVPRKPGMTRDDLFNINAGIVKSLASAIAEHCPGALVNMISNPVNSTVPIAAEIFKQKGTYDPKRLFGVTTLDVVRARTFLAHKKGLNVKDVDVPVVGGHAGITILPLFSQATPKVDLSDEELEALTKRTQDGGTEVVQAKAGKGSATLSMAYAGALFAESCLKGLNGAPDIVECSYVASTVVPGLPYFSSKVRLGPNGIEEILGLGSLSDY... | 5 |
O81263 | 2.7.1.21 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000255" | MRSLLAASTFLRSGASPLLRPLSRPLPSRLNLSRFGPVRPVSAAAAAADKSRGGGGSAMEAQPSYPGEIHVIVGPMFAGKTTALLRRVQVEAGTGSRNVALIKSDKDNRYGLDSVVTHDGTKMPCWALPELSSFQDKLGTEAYDKVDVIGIDEAQFFDDLHDFCCKAADRDGKIVVVAGLDGDYKRNKFGSVLDIIPLADSVTKLTARCELCGRRAFFTLRKTRETKTELIGGADVYMPVCRQHYLDGQIVIEATRIVLDLEKSKVIHAFK | 88 |
Q7UVC8 | 1.8.1.4 | ACT_SITE 452; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MKTARHELVILGGGPAGYVAAIRAAQLGIDVACIDDNPRFGGTCVRVGCIPSKALLESSHLYEEAQHKFADHGLNVSNVEVDLDVMMKRKEKIVESLTGGIDMLFDRRGVTAYHGRGRLRDVDSIEITPSEGAAEDQPTLVTADQIMLCPGSVPAQLPFVEEDGDRIGNSTTALSFPEVPEELVVIGGGYIGLELGSVWNRLGSNVIVLEAFDRIMPGLDKEMATLAHRSFKKQGMDIRTGTFVASAKVDPKPGDKKPCVIKIKNGETIRCDRVLLATGRAPATKSMGLEEAGVKLDERGFIQVNHQFETSVTGIYAIGD... | 36 |
A0A9R0J2X2 | 1.11.1.7 | ACT_SITE 111; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRHNMLVVGLILGVILVLSQVSESTHRLNLQIGPIIVGGKGKPPKGSPTTPPTLTPPPPSPTPPPGLKVGFYKGRCPNINVDVEANIATKVQQEFRKDPTILPALLRMQFHDCFIHGCDASILIKGSSSERTAGPNLSVRGYELIDTLKNVAEATCPDTVSCSDIIAIATKEVLKMGGGLGYAVETGRRDGLVSKAQDVDLPSPFASVSESISAFAAKNFSPEEMVILLGCHTVGISHCDFFEDRLYQGSSQFDENMDKDLREELKPVCPQNAGSDNFTFLDQNSESSNIVDNSFFQQIVKQRGILPIDQALANDPQTTG... | 14 |
C0LGK4 | 2.7.11.1 | ACT_SITE 657; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MVDQRRSALGFVLLLLCLVLFFDCVVVGQTQSRFSEKLILLNLRSSLGLRGTDWPIKGDPCVDWRGIQCENGSIIGINISGFRRTRIGKLNPQFSVDPLRNLTRLSYFNASGLALPGTIPEWFGVSLLALEVLDLSSCSVNGVVPFTLGNLTSLRTLNLSQNSLTSLVPSSLGQLLNLSQLDLSRNSFTGVLPQSFSSLKNLLTLDVSSNYLTGPIPPGLGALSKLIHLNFSSNSFSSPIPSELGDLVNLVDFDLSINSLSGSVPQELRKLSKLQLMAIGDNLLSGTLPVDLFSAESQLQTLVLRENGFSGSLPDVCWSL... | 99 |
O34577 | 2.7.1.25 | ACT_SITE 107; /note="Phosphoserine intermediate"; /evidence="ECO:0000250" | MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIANAAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVITAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGIDSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS | 90 |
A0A2K2A348 | 3.4.21.89 | ACT_SITE 163; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 213; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MMISLQILSPLPSSHFINPNPLSLQCSKNPNFYPKSFSETPYLVKSTHTHFLSFPKNSNLKLKTSLRLKLSVQFQRLICYGVKDSDEETKAVVDSGGDGGGGGGGGGDDGDGDADGEMEKKDGILPEWLNFTTDDAKTLFAAVAVSLAFRSFVAEPRFIPSLSMYPTFDVGDRVFSEKVSYYFRKPCVNDIVIFKSPPVLQEVGYTDDDVFIKRIVAKEGDTVEVHEGKLIVNGVMRSEKFILEPPSYELTPIHVPENSVFVMGDNRNNSYDSHVWGPLPAKNIIGRSIFRYWPPYRIGRTVLETGCAVDKQDSTSSSK | 178 |
P93604 | 2.7.11.1 | ACT_SITE 466; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSKLLVIALLLLPLINHGIYLATAWDDQDFFKYCPPSKCSQHGPMIRYPLCLESSNTSSSSSCGCAGRSIWKLACSGQDTILVHPVLGPYSVSAIDYRRSSMKITPLVDPCLVLQQKLIISRSSSSPQVDVINDEKPSFDENFFESSSATIVHCSREFTPAAAHADSIAGPVSCLSNTTHFFYLVNSDEDMSILPLDCKVVPVSDRGGISLPHMLKDQMFYNFTETAKKIPSFAETAVSWDEGDCRECELSGRRCAFSSQRDREFCMPDPHGSHIKVIAATSSVAAFVALLLTVATVLYLSLKTRYNAEIHMKVEMFLKT... | 99 |
A0A022RTZ9 | 3.1.1.11 | ACT_SITE 421; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGDDSKKKKMAVAGLCSILLVAMVVAVAVGIPKKNGDETDDAPTNGGGGVSATTKAVQAICSPTDYKQTCTESLSGANSTDPKELIKVAFEYTVKNIKESIKNSTLYKDAAADERTKGALDVCSEVLNTSIEDLERSFEKIGEFDMSKVDDLVDDVKTWLSGAITYQETCLDAFENTTGDTGEKMKNLLQTSGELLSNGLAMVTDFSSILSSLGGFSSRRLLSDEGRSLYHLDPTDYAPGEDPKMGFEGTPSFVDSKARKLLAATPATLKPNAVVAKDGSGQYGTIAAALKTLPKKTNQTFVIYVKAGVYKETVIIPRHV... | 125 |
Q8AAB1 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 609; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGYIGKRKAYPILIKGLKRLEYRGYDSAGVALISDNQQLNVYKTKGKVSELENFVTQKDISGTVGIAHTRWATHGEPCSVNAHPHYSSSEKLALIHNGIIENYAVLKEKLQAKGYVFKSSTDTEVLVQLIEYMKVTNRVDLLTAVQLALNEVIGAYAIAILDKEHPEEIIAARKSSPLVVGIGEDEFFLASDATPIVEYTDKVVYLEDGEIAVINRGKELKVVDLSNVEMTPEVKKVELKLGQLEKGGYPHFMLKEIFEQPDCIHDCMRGRINVEANNVVLSAVIDYKEKLLNAKRFIIVACGTSWHAGLIGKHLI... | 81 |
A0A9J7LHP0 | 2.7.10.1 | ACT_SITE 636; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MAPQGVLVGQQAIINCTINPDQGAAVTWTKDGHVVPDASTTVHRHGAGPINNGRYNEYRDRDIDIVGRASLRIQNTSLSDNGEFYCTVTVSGPLVVGPDSAVLTVFGRTGPPTISLSGTPSTEYPLTLTCTTAGGYPAATIGWYRGDENRTGEAEDQTDVEETDGSVTSSRQYTFTPTKNDTGVSYKCVVSQSVLQMDLEVETTLNVTYPAQITPTPPVTTTVIVGQTANFSCPAEGNPNNFTYIWKEGNRTINSAHEDQFSQSDGVLTISNVQRNQHDVVYTCDVSNNIGRADTASTTLDVQHAPDVSAPENVTVKEND... | 97 |
Q818U9 | 2.7.7.7 | ACT_SITE 116; /evidence="ECO:0000255|HAMAP-Rule:MF_01113" | MSTMREMYPKNGRVILHVDMNCFFASVEIAHDPSLQGKPLAVAGNEKERKGIIITCSYEAREYGIRTTMPLWEAKRLCPQLVVRRPNFTLYREASFQMFQVLSRFTEKIQPVSIDEGYLDITDCYALGSPLEIAKMIQQALLTELQLPCSIGIAPNLFLAKTASDMKKPLGITVLRKRDIPEMIWPLSVEAMHGIGEKTAEKLNEIHIHTIEQLAKGDEHIIRAKIGKHGIDLQKRAKGTDDREVDPSQMGQHKSVGNSMTFSKDMDEEKELLDMLERLSKSVSKRLQKRTLVSYNIQIMIKYHDRRTVTRSKQLKNAIW... | 121 |
Q9PVZ4 | 2.7.10.1 | ACT_SITE 1148; /note="Proton donor/acceptor"; /evidence="ECO:0000250" | MGQGVLRGEGHPNNNPNSKVGWKSLVGIITIFMLILCDQSDGKICYSMDIRNNISQFSMLEDCTVIEGHLQILLMFTSKPENFRGLRFPKLTTITDYLLLFRVYGLESLKDLFPNLTVIRGTRLFFNYALVIFEMVHXKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSIILDSVEDNYIELNRDNKEECGDVCPGTVKGKSKCKHTLVNGALVERCWTQDHCQKVCPSDCKGSGCLPDGQCCHPECLGSCRKPNDPSECTACRHFQNEGVCVTACPKGSYQFQGWRCIDFNTCQELNSRCQNSRDNSCPPYVIHKGE... | 97 |
I1JFF0 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKINILLCVVLLGFLGVCQGGSLRKKFYKDSCSQAEDIIKSKTQQHVSANPDLPAKLLRMHFHDCFVRGCDASVLLNSTANNTAERDAIPNLSLAGFDVIDDIKSELEAKCPKTVSCADILALAARDAVSVQFNKSMWEVLTGRRDGTVSNSNEALANIPAPFFNFTQLKQNFASKGLTLHDLVVLSGAHTIGIGHCNLFSNRLYNFTGKGDQDPSLNSTYAEFLKTKCQSLSDTTTTVEMDPGSSTNFDSDYYPNLLQNKGLFQSDAALLTEEQSEDIAKELVDQDKFFTEFAQSMKRMGAIDVLTDSAGEIRNKCSVV... | 14 |
P15731 | 2.3.2.23 | ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MSSSKRIAKELSDLERDPPTSCSAGPVGDDLYHWQASIMGPADSPYAGGVFFLSIHFPTDYPFKPPKISFTTKIYHPNINANGNICLDILKDQWSPALTLSKVLLSICSLLTDANPDDPLVPEIAHIYKTDRPKYEATAREWTKKYAV | 64 |
A0A061GFY5 | 1.11.1.7 | ACT_SITE 938; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MNKIRSVPTSSTKSFNSIINNLSSQGSYHEVLVTYTTMLNSSTPDSYTFPSLLKACTSLNLFSIGLSVHQQVILRGFSSDSYTASSLINFYSKFGHTKHARKVFDKTLNRDVVPWTAIIGCYGRGGDVGNAFSMLNEMRYNGVEPSPVTFLSLLSGALEVAQVQALHGCAVLYGFESDIAVGNSLLNAYSKCGSIGEARGLFELMDQKDKISWNSLISGYAQLGNVEEILQLLYAMKIENMGPDQQTFGSLVTAVAAQSTLDIGRVVHGQILRSGFDSDAHIETALMVMYLKCGTTDAAYQIFEGVSQKDVVLWTAMISG... | 14 |
A0A9J7L0A2 | 2.7.11.13 | ACT_SITE 577; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MVVFNGLIKVRVCEAQDLRPTDYATRHAVVRPASQVLDPYVKLNVDDTCFGQTTAKPKTLNPKWKEDFTTEVHNGHTVGVTVFHNTTIGPDDFVANCNVTFEELLQEQGGSADIWVDLEPAGKVHLIVELKGAACEPGKTTLAAAASASASASAVAEKVFRPGMGRHQRKNAMRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELVVTKCPGQKEPIQDEFLTSRFSINMPHRFSTHTYKRPTFCDHCGSLLYGLFKQGLQCEACKMNVHMRCQKNVAHNCGINPKEIALKLAELGL... | 100 |
A0A6I8N495 | 2.3.1.181 | ACT_SITE 188; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MGSSPVPAVRLVRMGLVPYGEALALQERWVRAVRAGAAPGAGAGAGAGALLVGEPSGPVYTVGLRGGLSPEERARLRALGAEVRATGRGGLATFHGPGQLLCHPLLDLRRLGLRLRQHVAALEACALRLCRRLGLPHARPLPPPYTGVWLRDRKLCAVGVRCGRHVTSHGLALNCCTDLSWFKHIVPCGLVGRGVTSLSEELQRHVTVEEVMESFLEAFEETYRCTLTSEESAGEGDVGDG | 55 |
A0A803SZZ8 | 2.7.1.11 | ACT_SITE 173; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MDNNKRLKSMAYAGNYCRITLEDLENSYHTHTTNVGMNAAVRAVVRMGIYVEAKVYFIYEGYEGMVDGGENIVEVTWESVSSILQVGGTVIGSARCKAFRTREGRLKAACNLVKCGITNLCVIGGDGSLTGANIFRTEWSGLLEELASQGEIDEEARKKYAYLNIVGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADYVFIPEYPPEEGWEDHMCSRLSENRARKKRLNIIIVAEGAIDSNNQPITSEQVKDLVVQRLGYDTRVTILGHVQRGGTPSAFDRILA... | 84 |
A0A067GSQ1 | 3.4.21.92 | ACT_SITE 193; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 218; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MAQSCAAALSSTAIFAAFCNHFPAESHSSSLRFSPLRLRKMIVSSNRERKCEKFGVKAAYTSDYSSLDDCESTWKGIWSIRNDLEVPSSPYIPTYAQGEQGGGPPPMLLGRFQNVLSQLFQHRIIRCGGPVEDDMANIIVAQLLYLDAVDPNKDIIMYLNSPGGSVTAGMAIFDTIRHIRPDVSTVCVGLAASMGAFLLSAGTKGKRYSLPNSRIMIHQPLGGAQGGQSDIDLQANEMLHHKANLNGYLSYHTGQTLEKINEDTDRDFFMSAEEAKDYGLIDGVVMNPHKILQPVAAAAGQ | 179 |
B7PHH2 | 2.7.11.17 | ACT_SITE 446; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | SRDKSRDRSRDRSRDRSSRDRSRDRSRNRSRNKSRDKSRDRSRDRSRNKSRDRSRDRSDRDKSDRSKSDRSKSDRDRSDRDKSDRDRSDRDKSDRDRSDRDRSDRDKSDRSKSDRDKSDRDKSDRDKSDRDKSDRDKSDRDKSDRNKSDRDKSDRDKSDRDKSDRDKSDRDKSDRDKSDRDKSERDKSDRDKSDRDKSDHDKSDRDKSDRDKSDRDKSDRDKSDRDRVDKNEKSDRDRSDKYEKSDRDRSDKYEKSERDRSDKDKSDRHDKSDRDKSDRHEKSDKSDRDKYDKSDRDKSERSSYKVSQTSYRIPLLLLSI... | 101 |
Q384J7 | 2.7.11.1 | ACT_SITE 152; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MRSTEVGRVVEDFIVLPPTPKSKWKLSDFELLHKLGGGNYGDVHLASVKDCNFVCALKRLSIKKLADFDIATQLRREIEIAFNTRHKYLLRTYAYFFDETDIYLIMEPCSNGMLYTELNRVKCFAPPTAARYVAQLAEALLYLHQHHILHRDIKPENILLDHNNNIKLADFGWSVHDPDNRRKTSCGTPEYFPPEIVGRQAYDTSADLWCLGIFCYELLVGKTPFVGKDTDQICKNIHSMHFKIPENIPSEAKDLIANLLLRDGSRRLALHRVVNHQFLLKYYYLPNNLQPPTGKRPRLDAEPTAGKEN | 99 |
A0A251PJP1 | 1.11.1.7 | ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKLCISALSVVLVLLFVSAAPQLAAKNVNKPRATVVRAADLLSFDHYLKTCPQAEGIIQQKTGDWIQKDFTLAASIIRLHFHDCAVRGCDASILLNHQGSERRAFASRTLRGFQVIDDIKAELERQCPKIVSCADILTSAARDATIIAGGPFWQVPFGRKDGRISISREADSVPQGHENVTALIEFFQVRGLNMLDLVTLSGAHTIGRSSCSSFKNRLSNFNGTRKPDPSLNSMYLNNFLKKKCQKDLDLIYLDAITPKTFDTQFYSNLHKKLGLLSTDQLLKSDVRTGPFVAALASQPSLFESQFAVSMVKLGNVQVLT... | 14 |
P0ACZ2 | 3.1.3.48 | ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 19; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 119; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P11064" | MAQLKFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLILAMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLSR | 149 |
D6WIE7 | 2.7.10.1 | ACT_SITE 1018; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MGIRHLLVLFVVVLLVLVVCDCRQHYNRNRRRGGAKDKALALHHQENEFHNKGKICIGTNGRMSVPSNREHHYRNLKDRYTNCTYVDGNLELTWLQDENLDLSFLQYIREVTGYVLISHVDIKRIVLPRLQIIRGRTLFKMNVRNEEFALLVILSKMYTLELPALRDVLIGNVGVFNNYNLCHFKTINWKEIITDPKSKYVFVYNFTSPERDCPPCHKNCEKGCWGEGEENCQKFSKENCSPQCYQGRCFGPNPRECCHLFCAGGCTGPKQSDCIACRNFYDDGVCTQECPPMKIYSPITYSWQDNPNGKYAYGATCVKN... | 97 |
Q0U7Z6 | 3.2.1.52 | ACT_SITE 353; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MHNFILASVATASALFASHVDAVAVNPLPKPANMTWGNSGCLSVGSLSLEAPEHAVLSAAFDRTTKSITDLKWVPQAIEAPIRQFQPFPTPAAGSKKRRSKRQYGSGNCTSTLGKVQVEIADTSAQLQHGVDESYKLDVTSDSDSIKISAKTVYGALHAMTTLQQIVINDGTGNMIIEQPVSIDDKPLYPVRGIMIDTGRNYLSPKKIMEQIDGMSLSKLNVLHWHMIDNQAWPIEIQAFPEMTEDAYSENEIFSQDSLKSLISYAAARGVRIIPEIDMPGHASSGWKQIDESILTCQNSWWSNDDWPKHTAVQPNPGQL... | 170 |
A0A067EYD7 | 4.1.1.50 | ACT_SITE 71; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 85; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 234; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MALPVSAIGFEGYEKRLEVSFFEPGVFADPGGRGLRSLSKHQLDEILKPAECTIVSSLSNEHLDSYVLSESSLFVYPYKVIIKTCGTTKLLLSIPAILKLSESLSLSVRSVRYTRGSFIFAGAQPFPHRSFSEEVAVLDGHFGKFGMDSTAFVMGSPDNTKRWHVYSASAEAGSHVNPVYTLEMCMTGLDRKRASVFYKTNESSVALMTEDSGIRKILPKSEICDFEFDPCGYSMNSIEGDAVSTIHVTPEDGFSYASFEAVGYDFEVVKLTPLLERVLACFKPAEFSVALHSDIVGDEHGDTFMLDLKGYSCGEKIYEE... | 196 |
P21734 | 2.3.2.23 | ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MSRAKRIMKEIQAVKDDPAAHITLEFVSESDIHHLKGTFLGPPGTPYEGGKFVVDIEVPMEYPFKPPKMQFDTKVYHPNISSVTGAICLDILKNAWSPVITLKSALISLQALLQSPEPNDPQDAEVAQHYLRDRESFNKTAALWTRLYASETSNGQKGNVEESDLYGIDHDLIDEFESQGFEKDKIVEVLRRLGVKSLDPNDNNTANRIIEELLK | 64 |
A3B529 | 2.7.11.1 | ACT_SITE 133; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEERSVLMERYVIGRQLGQGTFGKVYYARNLSSGQSVAIKMIDKEKILKVGLMEQIKREISIMRLVRHPNVLQLFEVMATKSNIYFALEYAKGGELFHKMARAKLNEESARNYFQQLISAMDYCHSRGVYHRDLKPENLLLDENETLKVSDFGLSALAESRRQDGLLHTACGTPAYVAPEVLSRKGYSGSKADVWSCGVILFVLVANYLPFHDRNIIQMYRKIAKAEYRCPRHFSAELKELLYGILDPDPSTRMSISRIKRSAWYRKPIAISALNNETGKKSCTSEAPFSGPTICISSERNQEPPNLHNLNAFDIISLST... | 99 |
Q9GT24 | 2.7.11.1 | ACT_SITE 131; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MSGGKSGSRLSAYSHLKEIGKGGFGVVYAAQRENGEKVAIKRIDKKVPKNRVWTEIQTMKELKKSKYVVEFYEDFVEDGYTYIVMELCEGGSLQAYVREHGALDDATAVHVLRQLISAVSFMHRVNVIHRDLSAGNVFIKDSKKKKMTVKLGDFGLATTLGRGETTCTIVGTPGFIAPQVYDQEYTQSADVYSLGAVLYTMLTARNPPPKGLPPTCGMSPNAARLVEQMMDTDAKKRIPLTQIVLSEFMYENTNENAVIFSREHSRDGRRQRSREPVRSSRDDRSRDGRALIRSSSQPAHSGRAPLSNRPIHDRMPSTSS... | 99 |
D7SP30 | 3.1.1.11 | ACT_SITE 225; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAMMMPKLLLLIFLLASASSTLNADGSNELVMTEEAYRSWVKRVGSFKHSVFQKAKNKLKPCLTIKVDKDQSLGHFASVQKAVDSLPVNNPCRVVISIGAGIYREKVVIPAIKAYVSLEGAGADKTIIEWNDTADLVGQTGRPLGTFGSATFAVNSPYFIAKNITFQNKAPPPPSGALGKQAVALRISADTAAFIGCKFIGAQDTLYDHMGRHYFRDCYIQGSVDFIFGNGLSLYEGCHLHAITNSVGALTAQKRDGLLEETGFSFVHCKVTGSGALYLGRAWGTFSRVVFAFTFMDKIINPSGWYAWGNKSREMTVFYG... | 125 |
Q942L2 | 5.3.4.1 | ACT_SITE 64; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 67; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 183; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 186; /note="Nucleophile"; /evidence="ECO:0000250" | MAIPRISPRKTLPLFAALALALAWAFAAPAFADGDDVVALTESTFEKEVGQDRGALVEFYAPWCGHCKKLAPEYEKLGASFKKAKSVFIAKVDCDEHKSVCSKYGVSGYPTIQWFPKGSLEPKKYEGQRSAEALAEFVNTEGGTNVKLATIPSSVVVLGPDNFDSIVLDENKDILVEFYAPWCGHCKHLAPIYEKLASVYKLDDGVVIANLDADKHKDLAEKYGVSGYPTLKFFPKGNKAGEDYDGGRELDDFVKFINEKCGTSRDTKGQLTSEAGRIASLDALAKEFLGAANDKRKEILSNMEEEVVKLSGSAAKHGKV... | 215 |
Q4Q5H3 | 2.3.2.26 | ACT_SITE 1595; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MDGFRLYMEGISLPEGSMRRANAELIGAINSPDPMVQHSGLQMLCDQLTMSSFISPSTMTTIPLVLPSLLRCIASSQVREVFITAARALTYIIDAFPRTFETFPTRDTLIEVLLQHLRSIQDVELSEQCITCLEMITRSQTGSRELLHNNGVEAVLGFADFFTLHKQRQIWTIVQRLVGEVDESSVQHITACLPTLRIGMTNGDSEIRQKAIATLAQAIEGVKTDRAIVETVFGDAADRIAVLLHERDVNDDTLSSALSLLYAGVQWSAGIAASVIQSDLLNTLLSLLQSTPVPAVVAEQHTAPSAGAGRVARRSAAAEL... | 65 |
W1NRM6 | 2.7.1.21 | ACT_SITE 96; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1" | MDVASATSFYGEIHVIVGPMFAGKTTALLRRVRAETEMGRSVAVIKSDKDNRYGLNSIVTHDGEKMSCWAMADLLTFKTKLGFDAYSKLDVIGIDEAQFFGDLYDFCRMAADYDGKTLIVAGLDGDYLRKSFGSMLDIIPLADSVTKLTASCELCGKKAFFTLRKTGDTQKELIGGADIYMPVCRQHYVSGQVVIEAARNVLESQQIQEDVYLEAAPLSSQLVPS | 88 |
O96651 | 5.6.2.1 | ACT_SITE 332; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383" | MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCGHVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDKEGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDARQELDLRIGCAFTRFQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFWHLQLLAGQPEVTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTVELMRICSSGLGIGPFQAMQI... | 221 |
W5MPE3 | 3.1.3.48 | ACT_SITE 1155; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000934-1" | MPLPFGLKLKRTRRYTVSSKSCLVTRIQLLNSEFVEFTLSVESTGQECLEAVAQRLELREVTYFSLWYLNKQSQQRWVDLEKPLKKQLDKYGLEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDVLEGRIPCSVEQAVQLAGLAVQADFGDFDHYESQEFLQKFVLFPIGWIQDERMLEEATQKVALLHQKYRGLQPPEAEMLYMQEVEKMDGYGQESYHAKDSQGNDLVLGACLDGIFVKHKNGRPPSIFRWNDITSMTHNKSFFALELANKEETIQFQTDDMETSKYVCRMCLARHKFYKINKTSLEPSESAPSE... | 149 |
P23780 | 3.2.1.23 | ACT_SITE 189; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P16278"; ACT_SITE 269; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P16278" | MLRVPLCTPLPLLALLQLLGAAHGIYNVTQRTFKLDYSRDRFLKDGQPFRYISGSIHYFRIPRFYWEDRLLKMKMAGLNAIQMYVPWNFHEPQPGQYEFSGDRDVEHFIQLAHELGLLVILRPGPYICAEWDMGGLPAWLLEKQSIVLRSSDPDYLVAVDKWLAVLLPKMKPLLYQNGGPIITVQVENEYGSYFACDYDYLRFLVHRFRYHLGNDVILFTTDGASEKMLKCGTLQDLYATVDFGTGNNITQAFLVQRKFEPKGPLINSEFYTGWLDHWGKPHSTVKTKTLATSLYNLLARGANVNLYMFIGGTNFAYWNG... | 163 |
I1KTS3 | 3.2.1.52 | ACT_SITE 344; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MTQQESTMSLIFLQLLLLLSCLTLNNSIAESTTIINVWPKPRNLTWSPPYQTTLLSSTFTITTTTNHHNKHLSIAIRRYQNLIKSEHHHPLVPQAVNISNKYLPPLQTLKVTVVDTAAELVHAVDESYTLSILPSSCATLTAKTVWGAMRGLETFSQLAWGHPTQVPVGVHVCDSPLYAHRGVMVDTARNYYPVKDLMRTVKALSMNKLNVLHLHLTDAESFPLVLPSEPALAEKGAYAPHMVYSPKDVKKLVEFGLDHGVRIIPEIDTPGHTASWALAHPDIVTCANMFWWPAGRDWPHRFASQPGTGHLNPLNPKTYQ... | 170 |
A0A8I6Y879 | 2.2.1.1 | ACT_SITE 495; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MAAHSVAAAHATIAARAGAAPSSPAAAPAERLGFRLSSLAGRALRSPLPARRGSPAAAASSRRSGGLHRVRASAAVETVEAAATGELLDKSVNAIRFLAIDAVEKAVSGHPGLPMGCAPMGHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDAVKEEDLKQFRQWGSSTPGHPENFETPGVEVTTGPLGQGIANAVGLALAEKHLAARFNKPDSEIVDHYTYCIVGDGCNMEGILTEACSLAGHWGLGKLIVFYDDNHISIDGDTEIAFTEDVSGRFEALGWHTLWVKNGNDGYDEIRKAIQEAKSV... | 51 |
P33157 | 3.2.1.39 | ACT_SITE 125; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 263; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MSESRSLASPPMLMILLSLVIASFFNHTAGQIGVCYGMLGDTLPSPSDVVALYKQQNIQRMRLYGPDPGALAALRGSDIELILDVPSSDLERLASSQTEADKWVQENVQSYRDGVRFRYINVGNEVKPSVGGFLLQAMQNIENAVSGAGLEVKVSTAIATDTTTDTSPPSQGRFRDEYKSFLEPVIGFLASKQSPLLVNLYPYFSYMGDTANIHLDYALFTAQSTVDNDPGYSYQNLFDANLDSVYAALEKSGGGSLEIVVSETGWPTEGAVGTSVENAKTYVNNLIQHVKNGSPRRPGKAIETYIFAMFDENKKEPTYE... | 167 |
Q8AA75 | 6.3.4.2 | ACT_SITE 384; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 510; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 512; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MGETKYIFVTGGVASSLGKGIISSSIGKLLQARGYNVTIQKFDPYINIDPGTLNPYEHGECYVTVDGHEADLDLGHYERFLGIQTTKANNITTGRIYKSVIDKERRGDYLGKTIQVIPHITDEIKRNVKLLGNKYKFDFVITEIGGTVGDIESLPYLESIRQLKWELGKNALCVHLTYVPYLAAAGELKTKPTQHSVKELQSVGIQPDVLVLRAEHPLSDGLRKKVAQFCNVDDKAVVQSIDAETIYEVPLLMQAQGLDSTILEKMGLPVGETPGLGPWRKFLERRHAAETKEPINIALVGKYDLQDAYKSIREALSQAG... | 252 |
Q9XVR6 | 3.4.19.12 | ACT_SITE 85; /evidence="ECO:0000250|UniProtKB:Q96DC9"; ACT_SITE 88; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96DC9"; ACT_SITE 245; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 267; /evidence="ECO:0000250|UniProtKB:Q96DC9" | MANEPQKSDDNGQAAEAVVTDDEIVLQDQQLKTIEDEQKSVPLVATLAPFSILCAEYDNETSAAFLSKATELSEVYGEIRYIRGDGNCFYRAILVGLIEIMLKDRARLEKFIASSRDWTRTLVELGFPDWTCTDFCDFFIEFLEKIHSGVHTEEAVYTILNDDGSANYILMFFRLITSAFLKQNSEEYAPFIDEGMTVAQYCEQEIEPMWKDADHLAINSLIKAAGTRVRIEYMDRTAAPNGGWHYDIPSDDQQIAPEITLLYRPGHYDVIYKKDSTEASEIEN | 175 |
A0A251NZP8 | 3.1.1.11 | ACT_SITE 154; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQSLVASILALFFLLGALEARYNLQDDVVVSAAIIVDQNGHGNFTTVQQAIDSIPSNNSQWTRIHINHAIYIEKVVVPKDKPYILLEGDLDHYPVIEFGDGGNVVTSPTFIAHADNFIAKNIIFKCSFLSVQDTLSDARGRHYFYECTIKGAIDFIFGSGQSLYEKCQIVSVTDVIGFPGYITANGRGGPDDPAGFVFKDCHVSGTGPINLGRAYGNHSRVLFSGTYMENIITPQGWMAAWNTGNEDLISYSEANCSGPGADLSQRVTWEKKLSDEEVESLTNAAKFIDQDGWLAKQPK | 125 |
A0A9R1WLC8 | 3.1.1.11 | ACT_SITE 208; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFRLQSNPFKTILVLYVLTFITFTVFLDGVDGKGILRLRPQGVDASFLTSQILPNRTFIVDINGPENYRSIQGAIDSVPDNNQDWVVIHVKKGIYREKVIIPREKPHIYLRGSGSTKTVIVWAESSENNYQSSTFKVEAPNFVAYGISFKNDAPTGIANTSHNQTVAAYVGADKVAFYSCGFYSSHNTLLDNKGRHYYDHCYIQGAVDIIFGRGRSIFHECEIFVINDRRMEIQGSVTAHTRSGLDENTGFVFVGGRVFGTGHAFLGRPRGTHSRVVFAKTYLSKTIRPEGWSDWNHHGSTENLCHCEYKCHGPGAGTSE... | 125 |
B9RSX8 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKSSLVLLLLFCVALVYQVGVCCGGGLRKNFYKDTCPQAEGIVRSIIWKRVSANSTLPAKLLRMHFHDCFVRGCDASVLLDSTPKNSAEKAAIPNLSLGGFDVIDEVKSKLETTCPGVVSCADIVALAARDSVSFQFKKPIWEVLTGRRDGLISRASEALADIPSPFFNFSLLKQSFANKSLTVHDLVVLSGYDIIDELLDSGKFFTEFAQSMKRMGAIDVLTGSAGEIRKKCNVVNS | 14 |
Q9C5C0 | 2.7.11.24 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MQQNQVKKGTKEMEFFTEYGDANRYRILEVIGKGSYGVVCAAIDTHTGEKVAIKKINDVFEHISDALRILREVKLLRLLRHPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQMLRALKFMHTANVYHRDLKPKNILANANCKLKVCDFGLARVAFNDTPTTVFWTDYVATRWYRAPELCGSFFSKYTPAIDVWSIGCIFAEVLTGKPLFPGKSVVHQLELITDLLGTPKSETISGVRNDKARKYLTEMRKKNPVTFSQKFSKADPLALRLLQRLLAFDPKDRPTPAEALADPYFKGLS... | 104 |
Q9XA16 | 2.7.11.1 | ACT_SITE 138; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEEPRRLGGRYELGPVLGRGGMAEVYHAHDTRLGRQVAVKTLRADLARDPSFQARFRREAQSAASLNHPAIVAVYDTGEDYIDNVSIPYIVMEYVDGSTLRELLHSGRKLLPERTLEMTIGILQALEYSHRAGIVHRDIKPANVMLTRNGQVKVMDFGIARAMGDSGMTMTQTAAVIGTAQYLSPEQAKGEQVDARSDLYSTGCLLYELLTVRPPFVGDSPVAVAYQHVREEPQAPSVFDPEITPEMDAIVLKALVKDPDYRYQSADEMRVDIEACLDGQPVGATAAMGAMAAGGYGAYPDDQPTTALRSDGGGGATTML... | 99 |
A8XSC1 | 2.7.11.24 | ACT_SITE 391; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MPSSTLLELAPNTHSKCKFETRNRSSSSSSGCSSSSTELYDLAAAHAALISRQQQILNQGIPIIPEHQLAAAAVAHHHHQLHPSVQHQLVAGHHHHHLPQVAHHPAILPRSDVIQQPSHFALHQHLQNLVQQQQQQQALHHHQQLVGDMALVSHTHPAAVGSTTCYEKNPQKQQQVPQIPTQPQVAHVSSNAILAAAQPFYQPPVQDSQPDRPIGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFRHDNVLSLLDILQPANPSFFQEFTSWHLTPSIHHQRLISHIKPICLFFVLPLVSLLCA... | 104 |
T1FUZ2 | 3.2.1.52 | ACT_SITE 1166; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MVMLGGRSIRGSRSAPWPAWHYCQVYCCLGALSILDCLNLVEVDELGWWLCERQLMSGGLNGRPEKMPDVCYSWWVVASLKMIDRLHWIDKKALVKFILASQDDETGGFADRPGDMPDPFHTLFGLAGLSLLQEDHDDNEVMSQPDNEVMSQPNNEVMSQPNNEVMSQNNDVESLYKEVTQPQLPPSRQHSPPRQKLQHPLNQIRFEAIDEVFCMPKKVVGRYFVRPQHCGTTSKDCGGCNEYTNEKCVDMILSYIMPYLLRYMRQGVFQHKALDTSIVSIQEEWSDYHDTATHAFHVTRDTASERKRQRSRPNNFYNKY... | 170 |
A0A2R6X3K0 | 2.1.1.37 | ACT_SITE 1390; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MGPVLGEAEWKDYGGNIIVRSYPNGRKTVIYVAPDGSKLRSWKTCLAYMEESPKSETNGTSTKSLPTKKDQKPSKTEKVNGESGHVSASDHEDGERKSVAVDFASELRKASNSSKSSPKEVAAIACEGADGSVKDLCKMKKQKVKAETLSESSSGVSSEDSKGASMRSRKRVGDSFGESAECKKARTTDCPPGLASKDNPADSSGRCEADTEEEITPQYSSRRPKRAAAGTNFKEKRIRLGERDARIDAKKERYAEDQTTMLMMTRSESDGSEVQQRTVLDFYLHDGHGRLRPVDPMENGTYLSGLCISKDGALDKDKGV... | 47 |
P50526 | 2.7.11.1 | ACT_SITE 267; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGSVNNEEKTLIEPQRLLRKNTWHPEVDDSEVPPSVFPEYPVHKAIQKTSDSFRKRNYSAGDYVIAPLGGEREGSSLTHSWTFQPGKHNQRLYSDNFQEAQRQWKRLQEWGEVKETKKIRKRFDRFSGRKYINHYEIIKELGRGMHGKVKLGRDTVTRELLAIKIIPKTERRPKLGRANASSQKEKVRREIAILKKCVHPNVVRLREVIDDPSSTKVYLVLEYMSGGEVPWTDCDSPVLSISEARQYFRDVVLGLEYLHYQGIIHRDIKPANLLLNSSNCVKISDFGVSYIANAGLNEDNDVELAKTVGTPAFFAPELCW... | 99 |
A9PAV3 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRIGYFGMLIFGLLAFMGSTEAQLKMGFYNTSCPKAEKIVQGFVNQHIHNAPSLAATLIRMHFHDCFVRGCDASVLLNTTSGEQPEKAATPNLTLRGFDFIDRVKRLVEAECPGIVSCADILTLVARDSIVATGGPFWRVPTGRRDGLISRSSEALSNVPSPMINFTTLQTLFANQGLDLKDLVLLSGAHTIGIAHCQSFSNRLYNFTGTGDEDPALDSEYAANLKARKCRSISDNTTIVEMDPGSRKTFDLSYYKLLLKRRGLFQSDAALTTNSNTLSMIRQILQGSIDFRSEFSKSMEKMGRIRVKTGSNGEIRRQC... | 14 |
Q0V1P1 | 3.1.1.3 | ACT_SITE 299; /note="Charge relay system"; /evidence="ECO:0000250" | MRRRPLCTSASRVTASLLLSFLAVSSAAELPILPAPPISPQPHSSEKDFSLRHIFHHGTYKYPELHRRLDVPENAAVWAAEHLHSEHREPVPRLRVKAEPMSIQRLADRSKEAIDGILEWGRMKGRAVQLAEDDWTIDEIAGPNVTDRETVLSFARMASNAYILEPNTGEWEDVGGGFNYTEDFGWESDGLRGHIFADTENSTVVIGLKGTSPAMFDGSETTTKDKENDNLFFSCCCGQGGQFLWRQVCDCQTSAYTCNSTCLVTALREKNRYYYAAQDLYHNVTALYPHAEIWMAGHSLGGAVSSFLSLTFGHPAVTFE... | 128 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.