Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A0A3B3H834 | 1.1.1.205 | ACT_SITE 331; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 429; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MADYLISGQTGYVPDDGLSGQQLFNGGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITMKTPFVSSPMDTVTEANMAIAMALTGGIGFIHHNCTPEFQANEVHKVKRYEQGFITDPVVMSPNERVRDVFQAKARYGFCGIPITENGKMGGKLVGIISSRDIDFLKEDEHSLLLNEVMTKKEDLVVAPAGVTLKQANEILQRSKKGKLPIVNEEGSLVSIIARTDLKKNRDFPLASKDSRKQLLCGAAIGTHNDDKYRLDLLVQSGVDVVVLDSSQGNSIFQINMIKYIKEKYPDLQVIGGNVVTAAQAKNLIDAGVDA... | 3 |
A0A803SP96 | 3.4.21.92 | ACT_SITE 136; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 161; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MSSNQVSHLSFLFLQHPLRLGCHILSVSRCLHQSPRNHIPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDGVASLVIAQLLFLQSESNKKPIHMYINSPGGTVTSGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGSPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEILKLKKQINGIYAKHTKQNLEVIEAAMERDRYMSPVEAQEFGILDKVLVHPPHDGEDEPELVQKETPPTASPPSSSAEP | 179 |
A0A022R9P0 | 1.11.1.7 | ACT_SITE 49; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | IICFASAQLKLGFYSTTCPKAESIIQGVVKQRFSKDRSITAALLRMHFHDCFVRGCDASILIDSTRTTSSEKDAGPNLTVRGNDLIDAAKKAVEAVCPSTVSCADIITLATRDSVALAGGPKYTLSTGRRDGLVSDANEVDLPGPSQSVSDAFATFRAKGMTMNDMVTLLGAHTVGVAHCGFFQDRLSNFQGTGKPDPTMEPALAARLLKTCGTQFRPLSSDPKVFLDQGTSFAFDNQFYNQTLFKRGIMQIDQELALDRLSAPIVSGFAKNGVAFQQSFANAMIKMSKIQVLVGKAGEIRKNCRVFNPKKKA | 14 |
Q924I2 | 2.7.11.1 | ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHANIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKLKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQPLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIPSTSR... | 99 |
A0A059DHM6 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKMITIFLGFIFLLPRGLGNLKVGFYHSTCPRAESIVHQVVQSRFQADQSITAALLCMHFHECFVRGCDASILIDSTDSNPMKKSAAPNLTVRGFEIIDEAKKNIEASCPSMVSCADIATLATRYAVFFAGGPNYDVATGRRDGIISARDEVNLPGPTFSVSQAQRAFAAKGFTLAEMLKVTCGASSSGDPTVSLDQSTPSIVDNKFYSEILVKRGILQIDQELTVDKSSTAIVAKFGLDANGFRLSFANAMVKMSNVGVLTGNAGEIRKNCRNINRT | 14 |
P29349 | 3.1.3.48 | ACT_SITE 583; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAA... | 149 |
P86210 | 4.2.1.11 | ACT_SITE 69; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P06733"; ACT_SITE 141; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P06733" | AAVPSGASTGIYEALELRAVEHINKTIAPALVSKLAMQEFMILPVGASSFRIGAEVYHNLKDATNVGDEGGFAPNILENKEALELLKAGYTDQVVIGMDVAASEFYRFTASAGIQVVGDDLTVTNPKRAASEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERYNQILRIEEELGSKSFRNPLAK | 200 |
Q61084 | 2.7.11.25 | ACT_SITE 489; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MDEQEALDSIMKDLVALQMSRRTRLSGYETMKNKDTGHPNRQSDVRIKFEHNGERRIIAFSRPVRYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHTSSSPHSGVSRQVRIKPSQSAGDINTIYQAPEPRSRHLSVSSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSFRKSQMSRARSFPDNRKECSDRETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGE... | 105 |
A0A3Q2GUR0 | 3.4.19.12 | ACT_SITE 139; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 139; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 244; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 259; /evidence="ECO... | MLPLQGQNTYTSNKTPRSLKIHSNGWEAEKILRTAGDAATYPSRLAHRRWEDALQRSRAPAFPSSAGTSSSLRVTRILGADWPARGTWAAAAGGGAGQGGRRGGAGGRGWRGWSGAGAVGSRQINMESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEE... | 175 |
Q5MD89 | 2.7.10.1 | ACT_SITE 1045; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MKRDFTFFCRIWIGIPFFSGLVNGFSMSPPTLDNTKDQLVINANDTLNITCRGQRILDWSWPEESLSKVEFTDRQGQQSPTDTPGYREIRLKECQGVAGKPYCKILILTNAQANDSGYYRCFYKDIKAVIDGTTAASIFVFVRDPEHPFIKRGDNDMETIFITDSETHIEVPCLVSDPDLKVTLFSLVPYPEPVDGSVVTWNNKKGWSIPRHIIQNTSTFIGFYCSISVQNSQHTSSIYVVQVIGLKFYEFKLFPEDSPVELMQGESLVLNCTALVDFNTGVDFQWDYPGKKENRLASLQPLRNVLDEATEISSILSIRN... | 97 |
A0A9R1WSB6 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEIDGKTNLLLLFGFYLLLSLITSSDSSLQYDYYRQSCPEANQIIKSTLRRIYDRNSSAAPAILRLVFHDCFVQGCDASVLLDPTEIMGSEKDTPPNQSLKGFEHLDIIKAELENACPGVVSCADLLVLAARESVILAGGPFYPVHTGRKDSSRSFPQLSYELPSPLDDLSTNIARFATRGFTDKETVTLLGAHSTGMIHCKFFEKRLYNFGGTDKPDPSMDSEFVELLRSVCNNRSHSHSHSQSPSASLSPSPSSSKTRQDQGMKMDYEGKGSGFGTLYYRSLLQGRGILFVDQQLTAGEETATWVRQYASDVSLFRKD... | 14 |
O01798 | 2.7.10.2 | ACT_SITE 344; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MRSKSSEGDLQPEDTQSREDKETTATYSEDTKPETQKERNAALDNLAKTPIQLVVQPTPLTPAITPCEAPPPPPPPKPSSDNNNSKRLKVKDQLIEVPSDEVGRVENNIDNFPFYHGFMGRNECEAMLSNHGDFLIRMTEIGKRVAYVISIKWKYQNIHVLVKRTKTKKLYWTKKYAFKSICELIAYHKRNHKPIYEGMTLICGLARHGWQLNNEQVTLNKKLGEGQFGEVHKGSLKTSVFAAPVTVAVKTLHQNHLSANEKILFLREANVMLTLSHPNVIKFYGVCTMKEPIMIVMEFCDGKSLEDALLSKEEKVSAED... | 98 |
Q8CXS6 | 5.4.99.12 | ACT_SITE 26; /note="Nucleophile"; /evidence="ECO:0000250" | MIVNFKTQRVIQNFSKFLLSLNAITDSGLSILNMTEVDENFDSRFSCNSREYEYWILNTKYPRPTWKNRTFWYQHRIDVPRLEAELELLKGEHDFRSLAKVASLKGRSTVRTILDVKLERSLELEGLLKVKIRANGFLHNMIRILTGTLLEISNGKRKDTNVLEILSSKDRTIAGITLPPYGLYFIRAYYDSYPKIDFMYSHLDFLK | 217 |
Q04770 | 2.7.11.22 | ACT_SITE 125; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MTRYEKKQQLGEGTYGVVCKAWDTVCNRYVALKKIKQEREDDGIPVTSVREIAVLLELKHPNVVDLYDIYLEDKFLYLVFEFCDEDLYQFMSRSSKIPINETRSIVYQILQGLAFCHYHQILHRDMKPQNILINKNGTIKLGDFGLARLTTINDRKYTSEVVTLWYRAPEILLGATQYGGAIDIWSTAAIFGELINKEELFKGRCKIDQLFKIFSQLGTPTEDIWNGVTKLPFYLSTFPKWKAKDLHTIFHTDERAVDLLQKMFIYTPEKRISAADALKHPFFDPLNKPNN | 102 |
P80210 | 6.3.4.4 | ACT_SITE 12; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 40; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125" | MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPGAWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV... | 253 |
D6WQ66 | 3.1.3.16 | ACT_SITE 295; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MNTEVKENCVITPELVEAGERYKAEANEYFKKQNYNAAIELYTKAIEANPNVAIYYGNRSFAYLKTECFGYALADASKAIELDKGYVKGFYRRAAAHMSLGKFKEALKDYEYVTKVRPNDKDAKSKYTECNKIVKKLAFEKAISVEDTKKNIASTINLDAMTIENEYTGPELEDGKVTLKFMKDLMELYKNQGKLHRKYAYKILLDVKAYFMKQPSLIDVVIGDEDKFTVCGDVHGQFYDLMNIFNLNGLPSETNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFMSRGNHESATMNQMYGFDGEVKAKYTAQMAE... | 144 |
B9HW40 | 3.1.1.11 | ACT_SITE 369; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDKQQLVLGFLNAYFLFYSLALVHGDSVTSCDQTPFPEACNYFIDTNISKTPPLFALRDQSLSITMNKAIEAHQMVSSMELSSFNQQAKLAWDDCLKLYEDTVDHVNRSMSSNNLADSQTWLSAAIANQRTCENGFIDFNIVSYLESLPNMLRNFTKLLSNTLSLNKAIISSTPILLDTKQDGGRRRLLVDGFPSWVPASDRKLLQSNGRAAPKADIVVAQDGSGDYKTISEAVAASAKLRSGTKSKRFVIYVKGGVYKENVEIKKSMKNLMFVGDGIDATVITSNKNTQDGTTTFRSATVGVSGKGFIARDITFENTAG... | 125 |
A0A067G5W1 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKGSLSFFLISLVALLLGACRGGGLGKNFYKETCPEAEDIVQKIIWKNVALNSTLPAKFLRMHFHDCFVRGCDASVLIDSTASNSAEKDSIPNQTVGGFDVIEEVKTELEKKCPGIVSCADIVALATRDSVSFQFEKPLWEVLTGRRDGRISLVSEANSQIPAPSFNFSRLKQSFASKGLTVHDLVVLSGGHTIGVGHCNFFSRRLYNFTGKGDADPSLDSTYAAFLRTKCRSLADNTTIVEMDPGSGMDFDNNYYKILRQNKGMFQSDAALLTDNGASNIVDELLDPAKFFTEFAQSMERLGAVGVLTGTSGEIRKKCN... | 14 |
B9RA28 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIMIVKAALLILALGLFLGNLAGLCNGALQVGFYSGKCGFADVEAIVAGVVTPQFFKDPTIVAALLRLQFHDCFVNGCDASLLLDGRSSEKTAPPNLSVRGYDIIDQAKTAVERACPGVVSCADLIAIATRDVVFLSGGGRYNVQTGRRDGLISAGQNVSILGPKASVPEAVAAFAEIGLNTTDMVLLLGAHSVGVTHCSLIKDRLYDFEGSGNPDPLMDPFLVNLLRFRCPQFPAIDNTVNLDQNPFSPFFMDVSYYQNIMMHRGILQIDQELGMDPLTMPIVRNLAGEFDFPTRFGAAMVKLGTIGVLTDKQGEIRRS... | 14 |
Q9KP30 | 1.8.4.11 | ACT_SITE 51; /evidence="ECO:0000250" | MLDKQTMVTAHNALPGRTTAMSIDDTHFVNGSSLTAAPQSGQQQILIGMGCFWGAERLFWQLDGVISTSVGYSGGFTPNPTYEEVCSGKTGHTEVVRVIFDPERLPLTELLRAFWERHDPTQGMRQGNDRGTQYRSAIYTFSEDQREIAEASKAAYQALLTAQHRPSITTEILPAGAYYFAETYHQQYLAKNPNGYCGLGGTGVCFPPHSTL | 39 |
A0A078IW90 | 3.5.4.5 | ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MDRPSFLIHAEEAESAAKRHGVSVVNLLPLLVNPAKPLARPPISKFPVAAVGLGSSGRIFVGVNVEFPGLPLHHSIHAEQFLVANLTLNSEPNLRHFSVSAAPCGHCRQFLQEIRDAPDIKILITDPNAFRDAVNENENDANENDAVKNENDAVKNKEEDGYVRLESILPHRFGPNDLLERDVPLLLEPHDNRLTILGVTNGHTDSDLKLTALAAANRSYAPYSRCPSGVALVDCEGRVYRGWYMESAAYNPSLGPVQAALVDFVANGGGGGFERIVGAVLVEKRDAVVRQEHTARMLLQVIAPKCDFEVFHC | 187 |
A0A096XJN4 | 3.2.1.1 | ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P56634"; ACT_SITE 238; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P56634" | MQHLSILLVVLGSSIAFAQHDPHFADGRNTIVHLFGWKWGDIASECENWLRKKGFAGVQISPPSENPIVSGRPWWENYQPVSYDLKNRNGDEDSLSDMIKRCNNVGVRIYADLVVNHMATSIGQGTADHSYDPGSKSYPAVPYSNENFHASCDIDYNDAASIRNCELSGLKDLDQSQDYVRGKIVDYMNHLVSLGVAGFRVDAAKHMWPADLAAIFGSVNDLNTDFFPSGSRAYIYQEVIDTGSDPIDNKDYTGFGSVCEFKYGIQLATCFRGSNPLKYLENWGTGWGLLDGGNTLVFIDNHDTERSSGSYLNYKESRAY... | 157 |
Q4WS33 | 3.2.1.23 | ACT_SITE 200; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 298; /note="Nucleophile"; /evidence="ECO:0000255" | MKLLSVCAIALLAAQAAGASIKHMLNGFTLMEHSDPAKRELLQKYVTWDEKSLFVNGERIMIFSGEVHPFRLPVPSLWLDVFQKIKALGFNCVSFYVDWALLEGKPGEYRAEGNFALEPFFDVAKQAGIYLLARPGPYINAEASGGGFPGWLQRVNGTLRTSDPAYLKATDNYIAHVAATIAKGQITNGGPVILYQPENEYSGACCDATFPDGDYMQYVIDQARNAGIVVPLINNDAWTGGHNAPGTGKGEVDIYGHDSYPLGFDCGHPSVWPKGNLPTTFRTDHLKQSPTTPYSLIEFQAGSFDPWGGPGFAACAALVN... | 163 |
P32571 | 3.4.19.12 | ACT_SITE 571; /note="Nucleophile"; ACT_SITE 880; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MEQNIISTIRDECIRHRSKYLTIAQLTAIAEAKINEFIITGKAKDQDLSSLLDKCIDILSIYKKNSKDIKNIISCKNKGAMISSNSVMIIQLNYVYYKVIHIIVTTNIPHLSEFAKIKLHKSTSDEGNGNNNNNEFQLMNIYNTLLETLLKDENIAKIKSFIKSSIKQTKLNHEQEECNLMRTGSYITSNQLNSLISSSANSASSQMEILLIDIRSRLEFNKSHIDTKNIICLEPISFKMSYSDHDLEKKSLITSPNSEIKMFQSRNLFKFIILYTDANEYNVKQQSVLLDILVNHSFEKPISDDFTKIFILESGFPGWL... | 175 |
P28583 | 2.7.11.1 | ACT_SITE 158; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAAKSSSSSTTTNVVTLKAAWVLPQRTQNIREVYEVGRKLGQGQFGTTFECTRRASGGKFACKSIPKRKLLCKEDYEDVWREIQIMHHLSEHANVVRIEGTYEDSTAVHLVMELCEGGELFDRIVQKGHYSERQAARLIKTIVEVVEACHSLGVMHRDLKPENFLFDTIDEDAKLKATDFGLSVFYKPGESFCDVVGSPYYVAPEVLRKLYGPESDVWSAGVILYILLSGVPPFWAESEPGIFRQILLGKLDFHSEPWPSISDSAKDLIRKMLDQNPKTRLTAHEVLRHPWIVDDNIAPDKPLDSAVLSRLKQFSAMNKL... | 99 |
B7PE53 | 3.2.1.52 | ACT_SITE 320; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MALFPPLQVTPTQGQAWPYPKEIQTGLEVFLIDPKSFQLVLRTPQGAPCELASSALRRYNPSLLFGGCTTRSGVHSRCAPKGRRAEASSSSVIGQLLQLDVFLTGQCEGMPHFSMDENYLTVALQSRAALQARSVWGIIRGLETFSQLVYPFNNTHFAVNRTEINDAPRFSHRGLLIDTSRHFLPLHSIIDTLDAMAYNKMNVLHWHIVDDQSFPFVSRTFPGLSDFVSALYFALSTSFLTLLRTAAFMRMALDVPAGHTQSWGAAFPDLLTPCYKGSTPNGKLGPMNPILNTTYQFLKYFFEEVVDVFPDQYLHLGGDE... | 170 |
A0A2K1KPA8 | 1.11.1.7 | ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MERRCKHLHWKAFLVTTPALLWFAMLLVAMRLSSAEPLRVGYYDLSCPSAERIIRQAMERGMQQDQGIAAGVLRLHFHDCFVEGCDGSVLLDNPNSEKTSPPNFSLRGFEVVDAAKADLEALCPGVVSCADILAFGARDAVELMGGLGWRVRAGRYDGRVSSAARALAEIPDPRYTVEEITALFARKGLSKSDMIVLSGAHTIGRAHCASVTPRLYPVQDPQMSQAMAAFLRTACPPQGGSAATFSLDSTTPYRFDNMYYTNLIANRGLLHSDQALINDMSTRGETIFNSFAAGPWAFQFSRVMIEMGNIQVKSGPDGEI... | 14 |
A0A3Q2I1H1 | 3.1.1.4 | ACT_SITE 584; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 717; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MSSVAPSLQAQNREQRRWGAIWVSVQEPAAPGEVGMGDRAQLTRDPVFFQTEGEGGGASAPAPRKMQFFGRLVNTLNSVSNLFSNPFRVKEVAVADYSSSSRVREEGQLILFQNTLHRTWDCVLVNPRNSKSGFRLFQLEVEADALVNFQQYSSLLPPFYESSSQVLHAEVLQQLSDLIRSHPSWSVAHLAVELGIRECFHHSRVISCANSVENEGGCTPLHLACRKGDGEILVELVQYCHAQMDVTDNSGETAFHYAVRGDNSQVLQLLGKNASAGLNQANNQGQTPLHLACQLGKQEMVRVLLLCNARCNIMGPGGCP... | 130 |
W5NAK4 | 2.7.11.1 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | CHDTAVMDPQNRAALDISTRNPQDDFEILHRVGGGTYGEVYKARNKQSGELAAIKIIKTEPEDDFSVIQQEIVMVKSCTHSNIVAYFGSYIRANKLWICMEYCGGGSLQDVYHVTGPLSEQQIAYVCREMLKGLEYLHSQKKIHRDIKGANILLNDQGEVKLADFGISAQITATFARRMSFIGTPYWMAPEVAAVEIKGGYNELCDIWSVGITAIELAELQPPMFDVHPLRVLFLMSKSGYQPPKLKDKAKWSSVFHNFIKMMLIRNPKKRPNASKMLTHVFVTQSSLNRTLTLELLEQMRHPEKLKDCVQLEEEEMEVL... | 99 |
A0A1U8BC49 | 3.1.1.11 | ACT_SITE 384; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAPCLLKAFLLVYAIFFTGTWALNSTSASSPTTTLLDAHLASIRSVCKSTPYPDACFDSLKLSISIDINPNIINFVLQSLETAFSEGGKLLDLLLNIGSSGVVENQRGAIQDCQELHQITMNSLQRSMSRISSSADSRKLSDARAFLSAALTNKDTCLEGLDSATGLLKPVLVDSVVNTYKYISNSLSMLPNPAVPQLKTKGGANRRLMGFPAWXSRKDRRVLQSFDGGYNPNDVLTVAKDGSGNFTTITDAINFAPNNSYDRTIIYVTQGVYQENVYIPRHKTNIVLLGDGADVTEITGSRSVGDGWTTFRSATVAVSG... | 125 |
A0A6I8PIX1 | 3.5.4.5 | ACT_SITE 73; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MAQVNALCHQTNLPQVEADQIQQLVRSCQAAKKFAYCPYSNFPVGAALLTTDGKIFSGCNVENASFPLGICAERTAIQKAISEGYKEFKAMAVASNKQDDFVAPCGACRQVMREFGKDWAVFLAKPDGSYITHSLQELLPLSFGPEDLKNL | 187 |
A0A251T0C2 | 3.1.1.11 | ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTFRYTNFRYANVLSLLVAVLASTHFLSTNLQYVKHLFEEFKAISLSPQPVVIRLDGHHHHHHGKKASKVDMCDTFPSDSIPPDTNTTTTFCVDHNGCCNFTTVQAAVDAVITLNPKRTLIWINSGIYFEKVIIPKTKPNITFQGQGYTSTAIVWNDTANSAHGTFYSGSVQVFSTNFAAKNISFMNVAPIAKPGEVGAQAVAIRVAGDQASFWGCGFFGAQDTLHDDRGRHYFKDCYIQGSIDFIFGNAKSLYEDCQLISMAPPLPMGQKSINGVVTAHGRASADEDSGFAFVRCAIGGTGRIWLGRAWRPFSKVVFAY... | 125 |
Q89YZ2 | 3.1.1.29 | ACT_SITE 21; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MIKYLIVGLGNIGPEYHETRHNIGFMTVEALARINNAPPFIDGRYGFTTSFSIKGRQLILLKPSTFMNLSGLAVRYWMQKENIPLENVLIVVDDLALPFGTLRLKGKGSDAGHNGLKHIAAILGTQNYARLRFGIGNDFPKGGQIDYVLGHFTDEDRKTMDERLETAGEIIKSFCLAGIDITMNQFNKK | 127 |
A0A2K1IBC8 | 3.4.19.9 | ACT_SITE 155; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 268; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 268; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MMAMRASALLYLVLLQCGAIVGARIPGIKLPSQRQEILPEALLNSRPLIGVLSQPGDGEEYQLTSRPLPPDYNTSYIAASYVKFVEMGGARAVPLIWNEPEETLRKKFASINGVLFPGGGASLKDTPFYRVAEKLFNWAIEANDRGDHFPVYGVCLGFELLSIIVSKNHYILERFEAENNPGPLLFVGDSAKHQSMFQWIPLRIIDELNDQKLAMQNHKWGLSPEKWISTPELNNFFQILTVTPDLNEKLYVSTVEARKYPILGVQWHPEKNAYEWGVDNIPHSADAIGVTQSVANYLIAEARKSSHKPASYEEEQAFLI... | 176 |
Q54DK3 | 2.7.11.1 | ACT_SITE 741; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNWDSNNNNNKNSNNNNNNSSSSSYNINNNYSSFNNSNNNNINNNNINTNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNSSNNYHLAHINVYQQYPIKPLPISFNSFNTNMFQQQQQQQQQQQQLPQHLPPLGSSGSSNGGPNLMGYAQIPPNYFKPLSPPSFHPPTSPQSFFNNNTNNNNNNNNNNNNNINININNNNNSNNYINDSTNSNNLNTSNGAINTSSHLFINSPNHHSDNRSFIESRSPASMNASPIHFNDPTFKVPVHLPSLSITNSPSLNSSIDSSYRLNNNNNNNNNNGSNNSSFNSTPTKFEQLQ... | 99 |
A0A0A0KK48 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSLGVSIKFVILLLSFLLLSNVGKSQELVVNYYNQSCPQAEEIIKQQVFSLYQKHGNSAISWIRNLFHDCMVKSCDASLLLEMKNEEGVVISEMKSPRSFGIRNLKYVNKIKQVLENECPNTVSCADIMALAARDAIVLLGGLEMEMKTGRRDSKESYGEMVEEFIPNHNDSLSLVLSRFQDIGIDAEATVALLGAHSIGRVHCVNLVNRLYPTVDPTLDPNHALYLQKRCPNPDPDPKAVQYARNDLESPMVVDNNYYRNVLDHKALLLVDQQLGSSPITLPYVQQMASNNTYFLAQFARALLLLSENNPLTDDQGEIR... | 14 |
P75960 | 2.3.1.286 | ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121" | MLSRRGHRLSRFRKNKRRLRERLRQRIFFRDKVVPEAMEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSIA | 58 |
A0A059C9V1 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRAQCIGMAALLMAVWIGVSDGQLAYDYYKTTCPNAEDIVRREMLSFAFLDATAPAAFLRLMFHDCQVQGCDASILLDAIGSKSEIKSSRNFGIRKLDAIEYVKSALEAECPGQVSCADIIALAARESVALSGGPHIAIPLGRKDSRASNYQQADAHLPSPSISVDAFLHIFMTKGLNLEESVAILGAHTLGAGHCLNIIDRLYNPKPDDLMNPVFEARLRLQCPTLNPLMNLTATSNDITPTIFDNQYYRDILLGKGLFFIDSSISRDPRTSDIVKQFAIDQDYFFRAFSSAFVKLSSANTLSKTKGEVRKQCSR | 14 |
A0A022RZG3 | 3.1.1.11 | ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | METVNSFKGYGKVDALEEAAFRRRTRKRVIILAVSLVLLVVLIVGVVAGTVAHRRSKGGVPATPTSTSAAIKSVCSVTQYPDSCFASLESGNSTNPGNIFKLSLMVAVDSLKRLSAAFPGEYANRTDKPLVKEALRVCAAVLSDAVDSLDDTISSVDGGGKAGVVSRIDDLKTWLSTAVTDQETCLDALEEAKAPFLEEIKLLAKNSTEFASNSLAIVSKLLGLLGDFDIPFNRRRLLAAPAGFPAWVAARERRLLQEFRPKPDVTVAVDGSGDVATINEAVARIPKKNLTKFVIYVRAGEYVENVELVKSMWNVMMYGD... | 125 |
Q9H422 | 2.7.11.1 | ACT_SITE 322; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIH... | 99 |
B9TAD0 | 6.3.4.4 | ACT_SITE 14; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125"; ACT_SITE 42; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03125" | MGKNVVVIGTQWGDEGKGKIVDWLTDHAQGVIRFQGGHNAGHTLVIGQGAAQREYKLNLVPSGIVREGVRCYIGNGVVLDAGHLLEEIGGLESVGVEVRSRLMISPGCPLILGYHVSLDKAREAARTQGKKIGTTGKGIGPTYEDKVARRALRVYDLFYPERFAEKLAEVLDYHNFVLTRHLNTEAVDFQAQLDAAMKHAESLRPLVHDVSAALYDAHQAGHNLLFEGAQGTLLDVDHGTYPYVTSSNCVAGQASAGSGVGPSMLHYVLGITKAYCTRVGGGPFPSELDIETDATPGHQMSDKGREIGTVTRRKRRCGWF... | 253 |
Q8TQG1 | 5.6.2.2 | ACT_SITE 187; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01897" | MAKYEEEKKSEAEMKKSYQATLIPEERDDKQEHGDGSIPLTREESGKKLELALSDPASDETEDEGPEPDNNGVTAILIDDEMKRSYINYAMSVIVGRALPDARDGLKPVHRRILFSMKESGITHDKPYKKSARVVGDVLGKYHPHGDAAVYDSIVRMVQDFSLRYPLIDGQGNFGSIDGDEAAAMRYTEVRMDRIAEEMLTDIEKETVPFRPNYDGSLEEPEVLPAKLPNLLINGSTGIAVGMATNMAPHNISEVIDGTLMLIDNPETPVSELMTVVKGPDFPTGAHILGTAGIRSAYTTGRGPVKIRAVAEIQELKKDR... | 222 |
A0A9R0JUD3 | 3.1.1.11 | ACT_SITE 423; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDTIKSFKGYGKVDETEEAAFQKKVKKRIIIISISAIILFAVIIATVAGVLLTRDNGGDKPSSSSPSQSLKVVCSVTQYPDTCFSSLSPLTSNSTSINPTNLFSLSLQVAKHSVSDLRSILPKDTNDTVLAKGLKDCGELFDDSEDQLGESLLSLSNSNKKSDNDLRTWLSAVLTNLESCVDGVSEINGTASLVEDLRLKMKNSTELVSNSLAIVSKIGTILGKFKNSNSIKVPKSFHLRKLLEYGSDQMFLDWVGPAERRLLLGEEAMGPGADAVVAKDGSGQYKTITEAIKAVTLKSKKRYVIYVKEGVYEENVVMGK... | 125 |
F7F7G1 | 3.1.3.48 | ACT_SITE 89; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MAAAEILEVRPGLYLGGVAAREQCRLREAGITAVLTVDTEEPSGDTEGLQTLFISARDEPETDLLSQLDNCFNFISRARADGAAVLVHCHAGVSRSVAVVTAYIMKSEKLTFEDAYGNLQTIRPEAKMNEGFEWQLKLYQAMGCEVDTSSAIYKQYRLQKVTEKYPELQNLPREVFAVDPTLISQELKNEILYKCRKCRRSLFRSSSILDHSEGSGPAAFAHKKMAPLIMNTGDETKCTSYFIEPVQWMESALLGVMDGQLLCPKCSAKLGSFNWYGEQCSCGRWMTPAFQIHKNRVDEMKMLPLLGSQTRKT | 149 |
P18431 | 2.7.11.1 | ACT_SITE 179; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSGRPRTSSFAEGNKQSPSLVLGGVKTCSRDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLE... | 99 |
Q6DGU9 | 2.5.1.18 | ACT_SITE 16; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MSGSRKVVELFYDVVSPYSWLAFEVLCRYRNVWNIDLKLKPAFLGAVMHDSGNRPPGMIPNKFLYMTSDLKHVSEYFGVPVRQPSNVFETMFEKGSLKAMRFVTAVAEKEKEGDVKLERVSRELWNRIWSNDQDITLPASFAEAGLKAGLTASEVDELLTLATSQPIKDKLKSVTSEAIKYKCFGFPTIVCHVDGKPEIFFGSDRFEVMAHIIGEKWMGPNPVKPMAKM | 77 |
A0A2C9U1C5 | 2.3.1.48 | ACT_SITE 327; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MGSIETPTNPENGSATLSPAVTAADLHQKPHSAVNGTPPQAAEMTQMESDSLKKRRSSVLPLEVGTRVMCRWRDGKYHQVKVIERRKMQCGGPNDYEYYVHYTEFNRRLDEWVKLEQLDLDSVETVVDEKVEDKGHEELDAASLREHEEFTKVKNIATIELGRYEIETWYFSPFPPEYNDSVKLYFCEFCLNFMKRKEQLQRHMRKCDLKHPPGDEIYRSGTLSMFEVDGKKNKVYGQNLCYLAKLFLDHKTLYYDVDLFLFYILCECDDRGCHMVGYFSKEKHSEESYNLACILTLPPYQRKGYGKFLIAFSYELSKKE... | 61 |
P57668 | 1.11.1.24 | ACT_SITE 60; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00269" | MAQVTLKGNPVNVDGQLPQKGAQAPAFSLVGGDLADVTLENFAGKRKVLNIFPSVDTPTCATSVRKFNVEAGKLANTVVLCISADLPFAQKRFCGAEGLENVVNLSTLRGREFLENYGVAIASGPLAGLAARAVVVLDEQNKVLHSELVGEIADEPNYAAALAAL | 12 |
Q7JY07 | 1.2.1.12 | ACT_SITE 150; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MSGIGINGFGRIGRMFARQALVRKDVKIVAINDPSLDPKYLAYMLRYDSTHGQFNQKISVDGNNLVVNGKKIQLLKESDVKKIKWCDLGVHTVVECSGRFTTLKACQGHLDSGAKKVVISAPSADAPMFVCGVNLEAYKPGTAIISNASCTTNCLAPLAKVVHDNFEICEGLMTTVHAATATQKIIDGPSSKLWRDGRSGMTNIIPASTGAAKAVGKVIPDLNGKLTGMAFRVPVPNVSVVDLTCRLSKPAKMDDIKKCIKAASKCEMKGILGYVEEEVVSTDFNGSRFASVFDAKACIALNDNFVKLISWYDNETGYSC... | 22 |
A0A9R1VVS3 | 3.2.1.23 | ACT_SITE 213; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 296; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MAKGRSLKSTKIIVLLLCLVAFSTVFAPLPSPLSNSLKPHNHHHHHHHHHQVVNARKFEIADDMFWKDGEPFRIIGGDLHYFRTLPEYWEDRLTRAKALGLNAIQTYVPWNLHEPKEGQLDFNAIADIVSFLELCQKLDLLVMLRAGPYICAEWDLGGFPAWLLTKKPPIRLRSSDPTYLALVDKWWGVLLPKIAPLLYHKGGPIIMVQIENEFGSYGVDKDYLHHLVNLARSHLGDDLILYTTDGGTRDTLIKGTINGDAVFSAVDFSTGEDPWPIFNLQKEFNTPGKSPPLSAEFYTGWLTHWGENIAKTDATSTASA... | 163 |
A0A1U8ASH7 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAIVALLCTLFVFSVSSPGDALSLDYYDKTCPQAESTITNVVKKAMTNDNTVPAALLRMHFHDCFIRGCDGSVLLKSVGNNQAEKDGPPNISLHAFYVIDNAKKAIESVCPGVVSCADILALAARDAVALSGGPTWEVPKGRKDGRVSKASETRQLPAPTFNISQLQQSFSQRGLSMADLVALSGGHTLGFAHCSSFQNRIHNFSPNSDIDPSMNQAFATSLRIVCPAHNKVKNAGSTMDSSVTTFDNTYYKLLLQGKSLFSSDQALLTTSKTKSLVSKFASSQADFNKAFVKSMIKMSSLAGGQEVRLDCRVVN | 14 |
Q5AGZ8 | 2.7.1.11 | ACT_SITE 334; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MISIVNGTSTLSLVAGSVETLNQAINFYTNILGLSVHSEQNDWTYLSNDDNKMIVKIQLDTKSGLSLDQINDRRTEIIAKLNITDWRSLDTTSVLKVQNLVALIETLTTFNYTLQITPNELYPNEVYCVDPLGYIIGFTACDEPLTLVPPLQKSHPKPGLVSNLMSKSGSQSRNIEETKAVRRNIAVMTSGGDSQGMNAAVRAVVRATIFHGSKAFAVQEGYAGLVKGGPEYIKEMKWQDVRGFLSEGGTNIGTARCMEFKERWGRLKGCKNLIDAGIDGLIVCGGDGSLTGADLFRHEWPSLIQELKDKGEITNEQFER... | 84 |
A0A139WNY2 | 3.1.3.1 | ACT_SITE 118; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MLAKFWIQCLCSLTVFVQCSWTAATVSQSTIHDQEYWYEQARIALRKRLQYATDRRPHAKNVVLFVGDGMGVATATAARILRGQRLGKRGEDHELAWDTFPAVAFAKTYNMDAQIGESSACATALMCGVKTNFETVGLDARGRFENCFSSFSSRVSSLIDWAQESGKSTGIVTNTRITHATPAALYGHSPSRYWEDDSKVPPASRKSCKDLARQLIENDPGRNINVLLGGGRRHWLPKVAHDPEQTKEEGRRLDGRNLIDDWVRDKKKRGLKAEYVWNKGQLDKINPNQVDYLLGLFAYSHMDFEADRDAGPSGDPSLAD... | 141 |
A0A3B3HBU9 | 2.7.10.1 | ACT_SITE 1137; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1" | MRPPAETRHLTLFWGLMLALSSCLRPATAKICGPSIDIGNDINEFRLLENCTVVEGYLQILLIGDKNNNANQEVFRSLSFPKLTMITDYLLLFRVSGLDSLSTLFPNLTVIRGRNLFYNYALVIFEMTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSIDWSSIMDAEFNNYIAGNKQSKECSDVCLGVTENNPLCRKAMIRNSYSYHCWNSNQCQKECPPSCGRRACTAEGKCCHPQCLGSCTAPDSDAACAACVHYFHQGRCMADCPPGTYRFEGWRCISAKVCSKVHHPDFDTFVIHGGECMPECPSGYTRSATNS... | 97 |
A0A078I2G4 | 1.11.1.7 | ACT_SITE 78; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGRSYTLLFILVTILVLVAAATAQGNRGSSRGGGGRRPRVGYYGNRCRNVESIVASVVRAHVRSNPANAPGILRMHFHDCFVRGCDGSVLLAGNTSERTAVPNRSLRGFEAIEEAKARLEVACPRTVSCADILTLAAREAVVLTGGQGWRVPLGRLDGRISQASDVILPGPFDPVDKQKRDFAAKTLNTIDLVTLVGGHTIGTAGCGLVRGRFFNFNGTGQPDPSINPRFVPLVQNRCPLTGDASARVDLDDGSVGRFDTSFLRNVRSSRVVLQSDLVLWRDPETRAIIERLLGLRRPSLRFGTEFGKSMVKMSLIDVKT... | 14 |
Q09178 | 2.7.10.2 | ACT_SITE 1003; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MPELAVMELGRQLCGKMKKQRKAEMTVLTVMKGLEIHFYLPDTHQLEYFKDCHTAEDLCVEGCQEDATSHLCADNLFALSEESQDLWYAPNHAFKITEETSIKLHYRMRFYFTNWHAPVRTESPVWRHSLFKHKGVSVSPKGPEGTPLLDAASLEYLFAQGQYDFLRGLAPVRAPQNEAEKHEIENECLGMAVLAITHHAKSNDLPLSGVGAETSYKRFIPDSLNRTIKQRNFSHVYVYNNVFKNFLNEFNSKTIQDSNITLYDLKVKYLSTLETLTQGLGRETIEPKILKVSGESDGSPALTLPSGDDGLGYEVQVSGT... | 98 |
Q9URT9 | 2.7.11.1 | ACT_SITE 150; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSDDSHLETKVVTDGTTGEKKTISYEPCRVLGSGSFGVVIQAKLVGTPGFIAVKRVLQDKRYKNRELQIMRAISHPNIIKLIAFFHTHNPSKDETHLCLLLEYMPETVFDDMRWYTRRRKSIPNLSIKLYAFQLFRALAYLHSTGVCHRDIKPQNLLVDYKTGILKLCDFGSAKVLVPSEPNVSYICSRYYRAPELVFGATHYTTKIDVWSAACVIAELFIGRPLFPGDSSVEQLVEIIRVLGTPSYHEISVMNPNYVNHSLPNVRPHTLESVMPHNCTKNAMDLLHKMLTYVPSKRISAIEVLTHPFFDELRDPNCMYH... | 99 |
C8VUX2 | 4.6.1.16 | ACT_SITE 240; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 248; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 279; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MNPSPDLPIPISYIAGNYFVFSVDAATFLRREHHICGVLAGTLPQVPQQNIFTGLPLELMPEEARLLAEKGVACIVDEVNFQKQGMNCLVEEDRKKYLEELELQGVESMQLQVRRKERQREEALKKKNEKAAAKAKKTERKQDTAEPASGEDSIVPFFDDAQPSVSPNHVSSRRPSTLATPDAMGITPAVSHPPLPQQPPAEHLLSLPEVPSSYPLFAHLHSKGYFLSPGLRFGCQYMAYPGDPLRFHSHFLVVSAEWDEQLDLMTIITGGRLGTGVKKGFLIGGADKSRGDPEEAGANVRSFSIEWAGM | 207 |
A0A8J1KL21 | 4.1.1.50 | ACT_SITE 70; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 84; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 231; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MKMEESAAHFFEGTEKLLELWFSQQDVSKGSGDLRDIPRFEWDKLLENVHCLIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLQALVPLLELAREYCGFDGIQNFFYSRKNFMKPNHQEYPHRNFHEEVEFLNQIFPNGAAYCMGRINSDCWYLYTLDIPDEYVISQPDQTLEILMSELDPEVMDQFYMKEGVTANDVTRVSGIRDLITGSVIDATMFSPCGYSMNGMKSDGTYWTIHITPEPDFSYVSFETNVSLTTYDDLISKVVDVFKPRKFVTTLFVNQLQVPRDQLCTGHNSDAA | 196 |
A0A8M9PMG5 | 2.7.11.1 | ACT_SITE 305; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1" | MGQKRKRDCFSDSDCVIAQNFHHGAQTKSCPNEAFNHLEPVEERRPSKKMRSGSSSSYFSAQSVTSEERNMEYYDCFMDFSVENPKLTETDTSSGLSLDEASSSSSSSSRTSSTNSNSSRTSSSNSSCSRKSCSNTSRTSRSSKTSNSSNSLGGQQVQDPDQDIDNDILGRYRIVKKLGQGGYGTVFEAVRVRDGLEVAMKVVLKSSDMDYLSIPGHPTPLPLEVALTILANNGPTVPQIIQMLEWQERPDSYIMILERPSPCEDLFDFLERHLGTLSENMTRHIMWQVVQAAHMCCQRGVLHRDIKLENLLINKETLEV... | 99 |
P36005 | 2.7.11.1 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MATDTERCIFRAFGQDFILNKHFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHPNIVWLFDTDIVFYPNGALNGVYLYEELMECDLSQIIRSEQRLEDAHFQSFIYQILCALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLSCSYSENHKVNDGFIKGYITSIWYKAPEILLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEETLQEIASQKVYNYIFQFGNIPGRSFESILPGANPEALELLKKMLEFDPKKRITVEDALEHPYLSM... | 99 |
H9G6L6 | 3.1.1.4 | ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 126; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | TRAAHTMNLLILFALATVGMAHSALPRNLWQFRNMIKCTMPSSDPLKDYNNYGCYCGLGGSGTPVDYLDTCCQIHDECYSAAKKHPNCKFILDNPYTKTYAYSCSDTEITCSEKNNECEAFICNCDRNAAICFSGAPYNKDYKNLDTSKHCK | 130 |
Q5FVR1 | 2.3.1.225 | ACT_SITE 179; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067" | MDFLVLFSFYLAFLLICVIMICIFTKSQRLKAVVLGGAQVCARVTPQCFQRAVQTLLHQLFHTRHPAFLALHLLLQGLVYAEYTYEVFSYCRELEFSLPCLLLPYVLLSVNLVFFTLTCSTNPGTITKTNVLLLLQVYEFDEVMFPKNSRCSTCDLRKPARSKHCRVCDRCVHRFDHHCVWVNNCIGAWNTGYFLIYLLTLTASAATIAILSAAFLLRLVAVSNLYQETYLDDLGRFQAVDTGFLIQHLFLAFPRIIFLLGFVIVLSLLLAGYLCFALYLAATNQTTNEWYRGDWAWCQHWPLVAWSPSAEPQIHQNIYS... | 57 |
T1F731 | 1.2.1.12 | ACT_SITE 152; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MSENAQIGVNGFGRIGRLVTRVAIRRGFNVNAINDPFIDVDYMVYMFKYDTVHGRWPGTVKAKDGKLIIDGKTIEVTNEKDPAKIMWRSSNVDIVVESTGVFTTLDKANQHLIGGARKVIITAPSADAPMFVMGVNEHTYDTSYNIVSNASCTTNCLAPIAKIIDENFGIVEALMTTVHSYTATQKVVDGPSNKDWRGGRHAAMNIIPSSTGAAKAVGKVIPSLNGKVTGIAFRVPTPNVSVVDLTCKVEKECTYEEIKEVVKKASQSPEWKGILGYTEDEVVSSDFTTTTFSSVFDAKAGLGLNRTFFKIVAWYDNEYG... | 22 |
Q8YZ37 | 1.3.3.3 | ACT_SITE 96; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MKQLQDEITQALTKLDGGSEFHEDSWERPEGGGGRSRVLRDGAIFEQAGVNFSEVWGSHLPPSILAQRPEAEGHGFYATGTSLVLHPRNPYVPTVHLNYRYFEAGPVWWFGGGADLTPYYPFAEDAAHFHQTLKLACDEHHPEYYPVFKRWCDEYFYLKHRDETRGVGGLFFDYQDGQGVLYRGPNPKGEAANYSNQVGEPASRDWEDLFSFIQGSGKAFLPAYVPIVERRHGMEYGDRQRNFQLYRRGRYVEFNLVYDRGTIFGLQTNGRTESILMSLPPLVRWEYGYQPEPNSPEAELYDTFLKPQDWSNWTANQ | 27 |
M0WUX2 | 1.11.1.7 | ACT_SITE 90; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASSRTAAMLVLVAAVLCPAAFSKTSSAFISMPTDHVGGSIPPVSPAEGLAFDFHADSCPQLQDVVRSAVQTALQSEIALAAGLLRIFFHDCFPQGCDASVLLTGDGSELQLAPNLTLQPRALQLIESIRAMVHAACGPVVSCADITALATRDAVAFSGGQGYDVPLGRLDSLAPAPSSAVFNLPQASSNAATLIDVFQTRNLDNVDLVALSGGHTIGKGHCSSFSNRFSEDSGFVRSLASNCSTDFNRLQDLDVTTPDVFDNKYFTNLQEGKGVFTSDQKLTADWRTEWVVNGFAGNHWWFFGQFAASMTKLGNLQGPQ... | 14 |
P29272 | 1.2.1.12 | ACT_SITE 151; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P0A9B2" | MTIRVAINGFGRIGRNVLRAIVESGRTDIEVVAINDLGQVETNAHLLRFDSVHGRFPAKVTSGDDWIDVGRGPIKVTAIRNPAELPWAGVDMAMECTGIFTTKEKAAAHLQNGAKRVLVSAPCDGADRTIVYGVNHATLTADDLVVSNASCTTNCLSPVAKVLHDAIGIAKGFMTTIHSYTGDQPTLDTMHKDLYRARAAALSMIPTSTGAAKAVGLVLPELKGRLDGVSIRVPTPNVSVVDLVFEAARDTTVEEVNAAIEAAACGPLKGVLGFTTEPNVSSDFNHDPHSSVFHMDQTKVMEGRMVRILSWYDNEWGFSN... | 22 |
Q0VA64 | 3.4.19.12 | ACT_SITE 205; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_03062"; ACT_SITE 798; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_03062" | MVKKRGKNLPAQDSLDAEPVCKHLRKALDEGSVKKALVNVEWTVCQECQADNKEKNNSDDELVEDPSVWLCLKCGHRGCGRNSASQHALNHYNTPRSEPHCLVLSVDMWSAWCYLCDNEVPYNRSSRLGQLVDYLQRKAKAKSKSTDSAALDEEVKAEIVAENEVKIEDQEEKPKGQAKWDKASSTQNNSTEPTVKGLSNLGNTCFFNAVMQNLSQTPAVRELLNEAKTLKKPVTVPLPDSSSPTNVEVHLEQQPGPLTLAMWQFLTEMQETKKGVVTPKEVFSQVCKKAIRFKGYQQQDSQELLRYLLDGMRGEEIQRV... | 175 |
Q9ZUE0 | 2.7.11.1 | ACT_SITE 495; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSDLGESPSSSPPAPPADTAPPPETPSENSALPPVDSSPPSPPADSSSTPPLSEPSTPPPDSQLPPLPSILPPLTDSPPPPSDSSPPVDSTPSPPPPTSNESPSPPEDSETPPAPPNESNDNNPPPSQDLQSPPPSSPSPNVGPTNPESPPLQSPPAPPASDPTNSPPASPLDPTNPPPIQPSGPATSPPANPNAPPSPFPTVPPKTPSSGPVVSPSLTSPSKGTPTPNQGNGDGGGGGGGYQGKTMVGMAVAGFAIMALIGVVFLVRRKKKRNIDSYNHSQYLPHPNFSVKSDGFLYGQDPGKGYSSGPNGSMYNNSQQ... | 99 |
A0A1S3XYC6 | 3.1.1.11 | ACT_SITE 364; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTYITMSNIYLIFPLLFVSSFFFPSTNGYSQAAIKFWCIQTPHPQPCEYFLTQNPKYSTPINKKSDFLKVSLELALDRALRAQTNAYSLGSKCRNEREKAAWADCLELYENTIHKIKSTVGPNTKCTAADAQSWLSTALTNLETCRAGFEELGVTDYVMPLMSNNVSSLISNTLSLNHGYYTEPTATQVDGFPTWVALGDRKLLQSSSPASQANIVVAKDGSGNFKTVKEAVAAAGKRKGSARFVIYVKAGIYSENVDLGSKLKNIMLVGDGIGKTIITGSKSVGGGSTTFKSATVAVVGDGFICRGITIRNTAGPTNHQ... | 125 |
Q69XZ1 | 1.11.1.7 | ACT_SITE 87; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MHGYGTRRSDSGGDRSMARLSTAAWPFLAAVAAALLCSVDAVIVEGLQVGFYNQTCPSAEEAVRDVVTSEIGLDRTIAAGIIRIFFHDCFVTGCDASILLDETPSGDVPEKESSANGFTLHGLRTLDVAKSTVESMCPRTVSCADILAFAARDAAVAAGIPFYEVAAGRMDGLRSNMDDLPGNMPTPSHQVPRMSELFVKRGLSQEDLVVLSGAHSIGGAHCFMFSNRIYGFSQGADIDPALEPAFAEKLRKVCPPRKDGDDPEQSPKVSFDGRTSEKLDNVYYSELLASRGLMTSDDALIKDPETKTTVDLFAGDNAVW... | 14 |
A0A452DII9 | 2.1.1.37 | ACT_SITE 1333; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MNECLRQGSQQMEELGQIHCSAQGCAPPSRMRDPCAEPVPLPPPTHGTASLCVVRPDFPHAWAGMVRAASARGPSPSVSARKARVACAAAASAAPSKMPARTAPARVPALASRAFSLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLRTEIKNQLCDLETKLHKEELSEEGYLAKVKSLLNKDLSLENGAHAFSREANGCLENGSQTSGEDCRVVMAEKGKPPKPVSRLYTPRRSKSDGETKSEVSSSPRITRKTTRQTTITSHFPRGPAKRKPEEEPEKVKSDDSVDEEKDQEEKRRRVTSRERVAGLLPAEEPGR... | 47 |
E9HPX0 | 2.4.1.18 | ACT_SITE 354; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 409; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MESKTKETEVNKQVDECVIVPDIEKLLERDTYLKPHEGEIRRRYARFEKLKKQICQCEGGIDKFTSAYKSFGIHIGEDNSVSCKEWAPGARQLYLYGDFNGWEKKRNPYEKLDFGKWQLHLPANPDGTCPIKHGSKIKVVVETEDGLLLDRLSPWAAYVVQPPPNEGCAYQQVVWNPQHKYEFKHSRPKRPNSLRIYECHVGIATTEGKIGSYKEFRENVIPRIVKLGYNALQLMAIMEHAYYGSFGYQVTSFYAASSRFGTPEELKELVDVAHSHGLIVLLDVVHSHASKNVLDGLNRFDGTDSCFFHGGVRGQHALWD... | 73 |
A0A2K1IY41 | 2.3.1.286 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MSSLGYAEKLSYRADVGTVGMPELYDPAEDLQSKIDKLAQLISESRHLVAFTGAGISTSCGIPDFRGPKGIWTLQHEGKPMPKIEMPFDQARPGVTHMALFELQQAGILKFIISQNIDGLHLRSGIPRSQLAELHGNCFREICSSCDKEYFRDFEVETLGCKPTGRRCTEHDCGGKLVDTIVDWEDALPPAELRAAEKHTKKADLVLCLGTSLQITPACNLPLKTVRAGGKMVIVNLQATPKDKSAALLVRGRVDEVISGIMSRLHRTIPPYVHIDRILLSYYYYWTKKKSVKWYFRISSIHGQKMALPFIKSIEVMFPN... | 58 |
A9UX52 | 3.1.3.3 | ACT_SITE 16; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 18; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MDVAAVYQRVRAVCFDVDSTVCIDEGIDKLAEYCGVGQAVAEWTARAMGGSVTFQDSFAARLDIIKPTTAQVRIQALVEEGPKLTPGVREVVAALQARGVQVFLVTGGIRPLILPVAAALNISPDNIFANVLHHDATGAYVDFDRNQPTSRTGGKQEVARLLREERGLAPLIMIGDGATDMEARPPADAFIGFGGNVVREKVKAGADWFISSFDELLALEKSQGASS | 147 |
A0A2K1J3J7 | 3.4.19.9 | ACT_SITE 161; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 274; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 274; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MKTSVCASALLCVILVQCVATGGTRISGIELPHRRHGNPQEVPSQNRPLIGILSQPGDGMGYSLTSTGGLEKPVPPGYSTSYIAASYVKFVEMGGARAVPLIWNEPEETLRKKFSAINGILFPGGGTSLKDSPFFRVADKLFNWAIEANDRGDHFPIYGVCLGFELLSVIVSKNHDILEPFHAENNPGPLLFVGDSAKHEGMFKWIPLNIIDELYEQKLTMQNHKWGLSPEKWISTPELNDFFQILTVTPDLNEKLYVSTVEAREYPILGVQWHPEKNAFEWGIDNIPHSADAIRITQSVANFLIAEARKSTHTPSSFKE... | 176 |
A0A2K1K766 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARIRFQQTLIVLLSLAAFFRVGDAGCPIASLGRRSLKQAPVPAQPALIFGFYDLTCPTLNSIIDTRMRFWVLQDIRTPGKVLRLFFHDCFAAGCEASILLNSTAEFAAEKDAPISVTLDKFQVIEDIKSEVETACPGIVSCADILALAAAKAVELAGGPILVTETGRRDGVVSYLAGATASMPLSTQKIPDLEAMFVQAGLDINDLVILSGAHTIGEVHCSNFADRFDPAANSPFGDVSFGQELLAFCTRNGAGDIATLNLKTFMDLQTPNSFDISYYVNLIIGRGVMTSDQVLFNDLRTQPMVREFAANRTLFFESFQ... | 14 |
Q9NY57 | 2.7.11.1 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q60592, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNCDPTFELEEMIL... | 99 |
O60172 | 3.1.3.2 | ACT_SITE 69; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P07102"; ACT_SITE 341; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P15309" | MQLCIISLWFLAAFIVNADNVQFEDYESNFFFKEHLGTLSPYHEPYFDGLDSAFPETCEIQQVHLLQRHGSRNPTGDVTATDVYSSQYLNNFQEKLLNGSIPVNFSYPENPLCFIKQWTPVIDAENADQLSSRGRLELFDLGRQLYQRYYKLFDSYVYDINTAEQERVVESAKWFTYGLFGDKMYEKTNFILISEGKAAGANSLSMYNACPVFKDNNFHKNATDAAHAVWRNIFIEPIVNRLAKYFDSSYKLTINDVRSLFYICEYEIAIKDHSDFCSIFTPSEFLNFEYDSDLDQAYGGGPVSEWASTLGGAYINNLAD... | 145 |
A5IBB3 | 1.3.3.3 | ACT_SITE 114; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MPISKTLPYNAIEQIKSYLLQLQNTICVSLESIDGKTRFHEDSWQRAAGGGGKTRIMANGNVFEKAGVNFSHVSGEQLPASASAHREELAGRHFSALGVSLVIHPQNPYVPTTHANVRFFVAEKEDSEPVWWFGGGFDLTPYYGFVEDCEHWHQTALNACLPFGETIYPKFKRWCDDYFFIKHRNEARGIGGLFFDDYNEISFDHSFELMRSIGDHFILAYEPIVARRKDIPFGNREKAFQNYRRGRYAEFNLVYDRGTLFGLQSGGRTESILMSLPPIVHWEYNWHPEKGSDEEKLYTDFLPAKDWLKKE | 27 |
B9SW55 | 3.1.1.11 | ACT_SITE 224; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVRGMTSLDAIKCAIILVLAVLISTATSDDTEQIPESQSALNSWFEANVKPYASRKGTLNPALEAAEANPKTIKVRTDGSGDFKTVTDALKSIPVKNTQRVIVDIGPGVYTEKITVDIQKPFVTLYGSPNAMPTLAFGGTAKEYGTDDSATLIVMSDYFVAANIIIKNTAPRPNGKPQGQAVALRLWGSKAAIYNCRILGFQDTLCDDHGMHFFKDCYIEGTIDFIFGLGKSIYLNSIIHVVDDKLLTVITAQAGSDPKEDTGFVFVHCSITGDGTGAFLGRAWMPMPRVVFAYTRMGKVIHPGGWFNNFHPERERTVSF... | 125 |
Q4WD73 | 2.1.1.37 | ACT_SITE 397; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MNRPTNDSLHSQEPPQPSEPICLDDSDDNSSVCDTYSNTDSSVTIDNDPDRSFFLDDEQFHPGGGRRTPTPFHIGPQTHQEIIDLTSGPELLVTEGDYLTDECFERLLRDWSRPGPAAAPLPIREASEWEKRPIDHACVDGIVYKAGHSLELHNGLFLRIETVLQDTAEEIFFQGRHLIRTWNHKGTYIPKWSNELVWIVNESTEVPLSFVKRFINIRFTNCCHVEQDLQKRNRPNDLFCRLKENLKSSQAAVEYLSFEDSDEGFAIGSMSLRHSWRGETRPFGSADANSQPQSPIIVLDADPVIDLTGIEKEDARVQKK... | 47 |
O81905 | 2.7.11.1 | ACT_SITE 651; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRGLPNFYHSYTFFFFFLLILFPAYSISANTLSASESLTISSNNTIVSPGNVFELGFFKPGLDSRWYLGIWYKAISKRTYVWVANRDTPLSSSIGTLKISDSNLVVLDQSDTPVWSTNLTGGDVRSPLVAELLDNGNFVLRDSKNSAPDGVLWQSFDFPTDTLLPEMKLGWDAKTGFNRFIRSWKSPDDPSSGDFSFKLETEGFPEIFLWNRESRMYRSGPWNGIRFSGVPEMQPFEYMVFNFTTSKEEVTYSFRITKSDVYSRLSISSSGLLQRFTWIETAQNWNQFWYAPKDQCDEYKECGVYGYCDSNTSPVCNCIK... | 99 |
Q9UVF4 | 1.1.1.8 | ACT_SITE 253; /note="Proton acceptor"; /evidence="ECO:0000250" | MSALLRSSLRFKHMSAVNRLTQQLRLLTASAPLSAANTAGKAPFKVAVVGSGNWGTTVAKIVAENCTAHPELFEPEVRVWVREEKVNGKNLTDIFNAEHENVRYLPKIKLPHNLIAEPDLLKAVEGANIIVFNLPHQFLAGVCKQLKGHVNPKARAISCLKGLDVTPQGVYLLSDVIENETGLHCGVLSGANLATEIALEKYSETTVAYNRPKDFFGEGDVTNDVLKALFHRPYFHVRCVQDVAGVSIGGALKNVVALCAGFVEGKNWGDNAKAAIMRRGMLEMINFSKRFFPETDINTLTVESAGVADLITSCAGGRNF... | 7 |
P0A7A5 | 2.1.1.77 | ACT_SITE 59; /evidence="ECO:0000250" | MVSRRVQALLDQLRAQGIQDEQVLNALAAVPREKFVDEAFEQKAWDNIALPIGQGQTISQPYMVARMTELLELTPQSRVLEIGTGSGYQTAILAHLVQHVCSVERIKGLQWQARRRLKNLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPPEIPTALMTQLDEGGILVLPVGEEHQYLKRVRRRGGEFIIDTVEAVRFVPLVKGELA | 49 |
F5HDV2 | 2.2.1.1 | ACT_SITE 419; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MSSFTETDQLAINTIRVLAADATAHANSGHPGAPMGMAPVAHVLFNRFMNFNPKNPKWLNRDRFVLSNGHACMLQYALLHLYGYALTIDDLKAFRRIDSITPGHPEAHDTPGVEVTTGPLGQGISNAVGLAIAQAHTAAVFNKPGYDLVNNYTYCFLGDGCLMEGVSSEACSLAGHLQLGNLIAIWDDNRITIDGDTNQAFTEDVLKRYESYGWHIVTVLDGDNNLDLIADAIKKAKEVTDKPTLIQLKTTIGFGSKKQGTHDVHGSPLKADDIKQLKEKFGFNPEESFAVPQEVYDLCHKASAKGAAKEEEWNQLFAKY... | 51 |
H3GE55 | 2.3.2.26 | ACT_SITE 589; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTTLASRGASLLAASDLSVCCAVLLLAAVLITRRAVRKTSSSDDVPHPLLLSAEQLADHRMLAAQREAERGFTACMTCGFKNFARVVHCALCGLSSTSQELPVAVRPVVDGPSEEQAAPTSLPRAHKRREWTRQLDVHNRLVWQRRLAEGGDHSPGYVLQFDLPPETEPESERGPFKHRERSLSTGYDPCAGVQFELLEPRDVDPTQFPLPPPRADTTDTMEDLKQMAVDLAAQDFPTKYAQFIARASAVLQAGDRSTRSFLSVHRDYVLEQSVQHINCIREADIRSVRLHVNFAGEGDVASDEKDVGGLHREWLTLLNE... | 65 |
P07601 | 4.2.1.20 | ACT_SITE 43; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 54; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALELGVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQLNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTIIEQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNEISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK | 202 |
Q9KRX4 | 2.3.1.286 | ACT_SITE 112; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121" | MSLPYRHVVILTGAGISAESGIQTFRAQDGLWENHRIEDVATPEGFQRDPDMVLEFYNQRRRKLLSDAIQPNPAHLALGKLEKELQGSVTVITQNIDNLHERGGSQNIIHMHGELLKARCPESNQTVEQKEDIRHGDLCHCCQMPAQMRPHIVWFGEMPLRMGDIYAALEQADLFVSIGTSGVVYPAAGFVHDARMHGAHTIEINLEPSAVESEFAEKRYGKASIEVPRLVEEILAAQARAKESAA | 58 |
Q9K440 | 3.2.1.21 | ACT_SITE 167; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1"; ACT_SITE 366; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR617736-1" | MSEYPGFPPGFVFGAATASYQIEGAATEDGRGPSIWDTYSRTPGLVVNGDTGDVACDHYHRYPEDVALLRDLGVDSYRFSIAWPRIVPDGSGAVNPKGLDFYSRLVDELLAAGIEPAATLYHWDLPQALEDRGGWRVRETAERFAEYTAVVAEHLSDRVPRWITLNEPWCSSFLGYSIGRHAPGAKEGRGALAAAHHLLVGHGLAVKALRAAGVREVGITLNLDRNLPATDSPADLAAVVRADTQHNLVWTEPILAGRYPATEEETWGELITGEDFRRDGDLELISQPLDFLGVNYYRPIVVADAPHRESDPARRVATDN... | 161 |
Q5KHN7 | 1.8.1.4 | ACT_SITE 490; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MFARQPLSQNLLRPLSRPSSSFSRTSTIPKLAFLQSARGFASASEPYDVVIIGGGPGGYVAAIKAAQLGFKTACIEKRGALGGTCLNVGCIPSKAMLNNSHIFHQTQHDLKNRGIDVSGIQLNLPKMLAAKEASVKALTGGIETYLFKKNGIDYIKGEASFETANKLNVKLLEGGETQVEAKNVIIATGSEVTPFPGLEIDEERIVSSTGALELKEVPKKMVVIGGGVIGLELGSVWSRLGAEVTVVEYLGAIGAGMDGEIGKQFQKILTKQGFKFKLNTKVISGHREGDIVKLKVDSAKGGKEETIEADVVLVAIGRRP... | 36 |
A0A9J7LCJ6 | 2.3.1.48 | ACT_SITE 424; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MAADWSKYFPYTNQTSCFIFYSSLSKMADDKENKKIGLKTTLDMVVEGCRLPVKMSILPNEEEEWPLAEILSRKEEKGKLEFYVHYIDFNKRLDEWVLPDRLRVEELQFPRKDQKTPQKQTSSAANSRPTTPDRELQEKKTTVDRSESDSPSPSLLSKKLSLPEQTSSPAAKLGGQGQTPQSQTKSNAGRKRKAIFLDEKQDLPPAYCNSLSSQDSQDAPATPQPSAPPQQPRQTGSMSSSHDENIITRIKNIETIELGKYRIKPWYFSPYPPELTTISIVFICEFCLKYVKSRKCLERHRTKCTLRHPPGNEIYRKSTI... | 61 |
A0A2K1XZC7 | 3.1.1.11 | ACT_SITE 385; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MMALANFLFILFLLPSLEALSNVIPSEEQELNTQALILQACSNVENLSSCLSNFQAELQKSGPPTAQSIIHAALRATLDEARRAIDTITKFNSLSISYREQVAIEDCKELLDFSVSELAWSLMEMNKIRAGIKNVHYEGNLKAWLSAALSNPDTCLEGFEGTDRHLENFISGSIKQVTQLIGNVLGLYTQLHSLPFKPTRNDNATTPKSSSDKFPEWMTEGDQELLKGSSLGMHVDAIVALDGSGHYRTITEAINEAPSYRTRRYIIYVKTGVYRENIDMKRKKSYIMLVGDGIGKTVVTGNRNFMQGWTTFRTATVAVS... | 125 |
W5MWB1 | 2.3.2.26 | ACT_SITE 876; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MATASTRSDSSNRHNGRSQLHTTVSSAKLKRKKNWFGTAIYVEVATDGEAKKTAKSNSSSNPKWDERLTLNVTPHTKLDFKVWSHHTLKADVLLGKATLDINQVLELHERKLENVREVLKLTLENKSGVIPTGELTVILDGLALDQDSLPNGNTDLTKVQQNGNAIHENGGETSTRARSSSTSGSSSGVDSQAPSTSSGQSVSVFVNGDGTSSPLHGTTSPGNTPAPKPSDTETTDRTVNGDIPGCTPAMQDVLPSAGCLAGGCDAATSTPVVNPAPAPSPPPPVPESPPMVATSGGAQAPSSSTSVSEARANSSSAAEG... | 65 |
H6QUT9 | 3.4.19.12 | ACT_SITE 149; /note="Proton donor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01100"; ACT_SITE 302; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01100" | MRGSTSILKLVVLLVMISGLVDGLGLGEPPDGKAYLAAWTDGSAPYHDSPSAFNRRIGQKAYAFQQAQTIPITPYNYTSGAGGPMNASQVVQTGTPAAIYLTVYPQSLGRVSDQDLRLLGQQIARYQLVPKTTSTSTPSRQVFLRFAPEMQGRWMAYGAQPTQFLALWKRMFAIIKALAPQTIIVWAPNGAMGYPYGLQWSDISSKADQDLLDTNKNGQLDSGDDAYSPYYPGDAYVDWNGISWYWKGNEYPYRLNQLLPAGYTAGAMTGKSPPGSIGSGGAQTFTNFYDNYCINKPCMFSEMGAAFHSNSTSTSAPSSS... | 175 |
B7ZRE2 | 2.7.10.1 | ACT_SITE 617; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MFSGRSLLLWGVLLGAALSVARPPSTLPDQVAPKTKTEVEPYSAQPGDRITLQCRLREDVQSINWVKNGVQLSETNRTRITGEEIQISNAGPEDNGVYACVTNGPSRTYTVLFSVNVSDALPSAEDDDEDDDNSSSEEKAAENSKPNRPLWSHPEKMEKKLHAVPAAKTVKFRCPANGTPTPTLRWLKNGRAFQQDQRIGGYKVRSQTWSLIMDSVVPSDKGNYTCIVENKYGAINHTYQLDVVERSPHRPILQAGLPANTSVTVGTTAEFSCKVYSDPQPHIQWLRHIEINGSRVASDGFPYVEILKTAGVNTSDKDME... | 97 |
H2M181 | 3.1.4.11 | ACT_SITE 330; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 375; /evidence="ECO:0000256|PIRSR:PIRSR628391-1" | MSCFKWSPKRTASEEIVYQENKKRVAQESGKRLGLDGDPDLQFLLVGGELIKVRSNSWQKNRFYKLQEDCRTLWHESSKVHKKKQTYSIDDIDSIRKGRQSEGLKKHTNPNDEEKCFSIIFKGSKKNLDLMASSAEEADRWINSLEKIISTMHNLDYQQKSEHWIISCMKKVDKNNDNMMSLKEVKDFMRQINVEVDDDYAADLFKKCDTSNSGTLEGSEIKEFYNLLTQREEINVIYEKCAQTEGLMSARDLLNFLLNEQREQVTIEHAQKLIENYEVDAAAKQRKCMTKDGFLMYLQQEESSIFNPAHKKVYQDMSQP... | 153 |
H3G8A6 | 3.5.1.2 | ACT_SITE 95; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 202; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 204; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MVTEIKSLTVGVLALQGAFEEHMAMLEGLRATTAKGQPVAVKTVAIRLPEQLQNVDALVLPGGESTTIGKVAVRWGLVEPLKKWVAAGRPIWGTCAGMIMLSQQAKHAEEGGQTLIGGLDVEVSRNFFGAQVRSFEMLVDGPPGFNTEPYNAVFIRAPAIISVGEEIEVLSRVANAKPADGSDPVDVIIAARKEHILVTAFHPEITDDSRWHQYFIETIVLPRV | 181 |
P08426 | 3.4.21.4 | ACT_SITE 64; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 108; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 201; /note="Charge relay system"; /evidence="ECO:0000250" | MKALIFLAFLGAAVALPLDDDDDKIVGGYTCQKNSLPYQVSLNAGYHFCGGSLINSQWVVSAAHCYKSRIQVRLGEHNIDVVEGGEQFIDAAKIIRHPSYNANTFDNDIMLIKLNSPATLNSRVSTVSLPRSCGSSGTKCLVSGWGNTLSSGTNYPSLLQCLDAPVLSDSSCKSSYPGKITSNMFCLGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGYGCAQKGKPGVYTKVCNYVNWIQQTVAAN | 177 |
A0A1D6FQT9 | 1.11.1.7 | ACT_SITE 104; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLSSSLPSRRHHSSRVVDRSQEMGASGGEKLGTLVCVLAHVSLLLVLVLAPCVCKATGGDYGGLSNDHYTESCPELETIVKKSLAPIFAVDITSPAALLRLLFHDCQVHGCDGSILLNSDERRHITSELGSRKNLGIRHVGTVGLVKAAVEAACPGRVSCADIVVLAAREAVAHTGGPRVASVPLGRRDATTTSTQAADAQLPSCFLGIDGALDIFTSRGMTVEETVAILGSHTLGGGHCVNIDTGRARRDKAFEALLHLQCPKTMPPLITEAVVFVPSDLTPTWFDTHYYRGAAAGRGLFNVDDEASTYARTAGYVRRF... | 14 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.