Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
A7S0E8 | 3.2.1.52 | ACT_SITE 501; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MAAKIDLRYDVISNLQGDGRYSAKLTLTNTGTTVITKGDWDLVFCSIRLIVPDSSTERAGVKVSHINGCLHKMTPLETFPVLAADQNVEIPFRAMNWVVAKTDIMPNWFFAADGLEPRVVKSTEGEGLSFVGKFTTEEQWKRYANDQYNPYTAQGRYDVIGFDDLGEDGWGDIVTIPQPMTVQGLERKSRVGIRADWKIFADGGFQKEAQLLKAKFNAQIASSMPFNQSKLIRLVKGDPNVTRGVASSEAYSLEIKVAEKEIKLTGSHASGVFYGVQTLIALADKENTVPMVTIKDAPRYGYRGMHLDVGRNFMEKAAVL... | 170 |
Q38FY2 | 2.7.11.1 | ACT_SITE 210; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MSTRLCEPSLRDDGAQRGTPASHGKWCDTGAFKLDETPSPVVANVSSTSDASFQFNRTPSPGKHQNHAADRSMWSLDDFVIIRKLDEGRFGKVYLAREKQSKCAVVLKCISKDMIRFHSLAHQLQREVELQEYAGRYHKNVLRLFAYFWDDVRIVLVLEYADSGTLQDLLDCYREKEQRSSLPDDKVRTILLQLLSALAFLHERDIIHRDVKPDNILFHGEKLLLADFSWAVRVNNSDPRYCRRHTVCGTLDYLAPEQVLKRGCTTKADLWAVGVVAYRMLCGFLPFEMLDARDVCSCIASGAIRYPSQLSPTARHFLQG... | 99 |
A0A2K1XMN9 | 1.11.1.7 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSLAISFLLLILISPSKAVLNNAHYYDQTCPQAEKIIFETVRNASMHDPKVPARILGMFFHDCFIRAWISIIQRIDDAKAKLEMACPHTVSCADIIAIAARDVVAMSGEPSWNVLTGRKNGRVSKANDTITLPAPTFNAMQLIQSFAKRGLGVKDLVALSGDHNLGFSHCSSFEARLQNFSSVHDIDPSMNTRFAGNLKRKCPKPNKDHSAGEFLDSTSSTFDNDYYKRDIEGKGIFGSYHALLGDYREFAASMVKLGKVGVIKNGEVRFKCRVVN | 14 |
Q9XCX9 | 3.1.26.3 | ACT_SITE 44; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 116; /evidence="ECO:0000255|HAMAP-Rule:MF_00104" | MSNSLDRLERKLGYTFKDRDLMVLALTHRSYAGRNNERLEFLGDAILNFVIGEALFHHFPQAREGQLSRLRARLVKGETLALLARGFEVGDYLRLGSGELKSGGFRRESILADAMEALIGAIYLDTGMDSARERIIAWLGPQLRELTPVDTNKDPKTRLQEFLQSRGCDLPRYEVVDIQGEPHCRTFFVDCEVALLSDKTHGHGGSRRIAEQVAAAAALVALGVENGHD | 138 |
Q8Y7J0 | 5.6.2.2 | ACT_SITE 122; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_00937" | MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPARFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDNPLCTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRVVVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLF... | 222 |
Q54TW2 | 2.7.11.1 | ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MENIVITNTSGGGGGGVPSSSTDPPNNTTTTTATASAIDLNMSLSPFLSSPSLSSPSIQSAKKKTIEDFIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTN... | 99 |
C5Z864 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVRRMVLVAALVVATVAVLAGGARAQLKEGFYGSTCPQAEKIVKEFVKAHIPHAPDVAATLIRTHFHDCFVRGCDASVLLNATGGKEAEKDAAPNQTLRGFGFIDRIKALLEKECPGVVSCADILALAARDSVGVIGGPFWSVPTGRRDGTVSIKQEALDQIPAPTMNFTTLLQSFRNKSLDLADLVWLSGAHTIGISHCNSFSERLYNFTGRAVPGDADPSLDPLYAAKLRRKCKTLTDNTTIVEMDPGSFRTFDLSYYRGVLKRRGLFQSDAALITDAASKADILSVVNAPPEVFFQVFARSMVKMGAIDVKTGSEGE... | 14 |
Q6YXM7 | 3.4.21.92 | ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 127; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MPIGVPKVPFRLPGEEDAVWIDVYNNRLYRERLLFLGQHVDDEIANQLIGIMMYLNGEDENKDMYLYINSPGGAVLAGISVYDAMQFVVPDVHTICMGLAASMGSFILAGGEITKRIALPHARVMIHQPASSYYDGQAGECIMEAEEVLKLRDYITRVYVQRIGKPLWVISEDMERDVFMSAQEAKTYGIVDLVAIENT | 179 |
Q9SR87 | 2.7.11.1 | ACT_SITE 495; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGIARSINSFMFFFFLMILSNASKSSVLAEATTAKFTFIGFKENQTDIQTEGASTIQHDNDLLRLTNRKQNVTGTAFYRKPIRLRELTNSSDIKVCSFSTSFVFVILPSSPGNGGFGFTFTLSPTPNRPGAESAQYLGLLNRTNNGNPSNHVFAVEFDTVQGFKDGADRRGNHIGLNFNNLSSNVQEPLIYYDTEDRKEDFQLESGEPIRVLIDYDGSSETLNVTIYPTRLEFKPKKPLISRRVSELSEIVKDEMYVGFTAATGKDQSSAHYVMGWSFSSCGENPMADWLEISRLPPPPRLSNKKGYNSQVIVLIVALSI... | 99 |
D7U2P4 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATCERPGFQALAWLLCLIFAHLSASTMAFPRSSLSSSLKVGFYGSTCPSAEAVVRKTVDKAVSRNLGIAAGLIRMHFHDCFVRGCDASVLLDSTPGNLSEKEHPANNPSLRGFQVINKAKAKLEALCPETVSCADIIAFAARDGALKVGGINYTVPGGRRDGRVSRKDEVAESLPPPHFNAEQLELRFARKGLSLDEMVTLSGAHSIGMSHCSSFSKRLYSNGTHAHDPSMRRKYVSFLRTKCHPQRNGGQNPTVPLEAKTPGRLDNKYYKELEKHRGLLNSDQTLMSSQSTAWMVRNNARHGSTWAAKFAAAMVHMGS... | 14 |
A5F028 | 2.2.1.2 | ACT_SITE 132; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MSNKLAQLRKLTTVVADTGEIDAIKKYQPEDATTNPSLILKAAQIAEYAPLIDQAIAYAKTQSNDKAQQVQDTCDMLAVNIGKEILKTIPGRISTEVDARLSYDMERSVAKARQLVKMYNDAGISNDRILIKLASTWEGIRAAEILEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRIMDWYKAKEGRDFAASEDPGVLSVTKIYNYYKEHGYKTVVMGASFRNIGEILELAGCDRLTIAPSLLAELEAAEGELVAKLVDSKGSKARPAPMTHSEFLWEHNLDAMAVEKLAEGIRNFAVDQGKLEAMIAAKL | 52 |
F7A6K0 | 3.1.1.4 | ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 115; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MESVRLLLLLLFTTVSGKSHVHRRGLTELATTITCATKSSALVYLKYGCYCGLGGSGQPQDQVDWCCQKHDCCYKAASDAGCIPKLQTYSWNCVNNTVECASSQSKCAAIACKCDQELSHCLASAKYNKKHFLSLASDCGDQSPKCE | 130 |
M5XMU7 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEMSLATIIFTFTFTFCTIFIIPCSEAAEKGQGNGLHVGFYGIRCPNAEQIVADVVSKAVEADQKLPAAFIRLFSHDCFVKGCDASILLDSTPSHEPVEIQSPANVGIKGLEVIDEIKARLEAECPETVSCADILAFAAREAVALAGLPRHKVPAGRRDSRTSRATDVTLPAPATPLNEIIEYFSRRGMTSDEIVVLSGAHSIGAVHCSFFDYRLYNYDQTQAQDPALDRFYAANLSQQCPAPNTLPEAEAKNRVVDFDPITPLVLDNQYYANLMQGKALLQSDQALVTDPRTKAMVISMAASADSWTQRFVRAMIKMGR... | 14 |
M5XEJ2 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALVLAMALAMVLAVAQEVEGQLMVGFYGETCPQAEPIVRNVVREAILSDTNMAPVLLRLHFHDCFVEGCDGSILIENGPSGERHAFGHQGVGGFEVIEKAKAELEAACQGVVSCADIVALAARDAIAMAGGPAYEVPTGRRDGVVSNMSLADDMPDVSNSIQQLKVKFMRKGLTEKDLVLLSAAHTIGTTACFFLTKRLYNFFPGGGSDPAINPTLLVELKQKCPQNGDVNVRLPIDQGSGQAFDLHILQNIRNGFAVLESDAKLNEDAVTRGIMDNYFGFFSNLPFGPSFEADFVEAILKMGQIGVRTGFQGAPRRVC... | 14 |
Q9KVV4 | 2.7.11.1 | ACT_SITE 213; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01497"; ACT_SITE 229; /evidence="ECO:0000256|HAMAP-Rule:MF_01497" | MVKGSVMSPFYSMTQATFHFDALTPDLIWYALESIGIRAESGFLPLNSYENRVYQFTDEERRRFVVKFYRPQRWTDEQIQEEHDFALELEQEEIPIVPPLRLNGATLHHYQGYRFALFTSMGGRQYEVDNEEHLEWVGRFLGRIHKVGASKPFLHRPTLSLDEYLHQPRHTLEYSHCIPAHLQRVFFHDLDILIAEIKQHWVPTQPQIRLHGDCHPGNILWRDGPMFVDLDDARNGPAIQDLWMLLHGDRQDKLIQLDIVLEGYQEFCDFNPQQLKLIEPLRGLRMVHYMAWLAKRWQDPAFPIAFPWFNDAKYWENQIL... | 99 |
A8WRJ3 | 3.1.1.4 | ACT_SITE 787; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 909; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MGSSNKDGPSCLPEVHKEPNLAISESTHSSDWYSATSSEDCWQGASQSFSGGKSNGKPITQKENSAAGEKMSCEMSDPKSCSFVPENNEKDSIHVGNFELKKGRSYSNPDLLVSMSPLAYRGEQGKQEMIASRQDLKEETTEIVAVVETVQTDDTTTTTAVITSTTMSGTASQDDFILVEAEQDEHIGLCDDTMPLVDKKDLSTTSATSSPARQITPRVESGLSFERVVSLVSVFPAMINKLLNKPWYPSRCDEVIQFPKEELHNYEIVPTEVDDEHFVIVTGIRSAEGRLPDSIYHLVFAYDGFFETDSTRPFSLFRAT... | 130 |
A0A9J7MJF8 | 2.7.7.7 | ACT_SITE 99; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MFGRFLVYSRRFGRFFHTSRTLQCSDDMSKRKGIAENVNSDFCDFLTELANYEKNVNRQMHKYNAYRKAASVLAKHPTRIKNGTEARKLDGIGEKIAKKIDEFVQTGTLQKLVKIRASDTNQAINLLTRVTGIGPAAARKLVDEGITTIEDLRKNPGKLNHHQQLGLKYFEDFEKRIPREEMLEMQSLIQGEINQLDSDYVATICGSFRRGAASSGDIDILLTHSTYSSEDKKKPELLKQVVHHLEKSKFVVDTISLGDTKFMGVCRLPAGKGSKERTFRRIDIRLLPNDQYYCGVLYFTGSDVFNKKMRAHALEQGFTL... | 121 |
Q10452 | 2.7.11.1 | ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNHGTKIPVDPFRIIKETARDGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELR... | 99 |
A5I458 | 3.5.1.88 | ACT_SITE 132; /evidence="ECO:0000256|HAMAP-Rule:MF_00163" | MALRQIRLFDDEILRKESKVVEIVDDKIRQILNDMADTMYNTENGGGLAAPQVGILKRLVVIDMGQGLIKLVNPKIIKQEGTQEVIEGCLSIPNKFGRVIRPAKVTVQALNEDGEEIILTGTGDLAKCFCHEIDHLEGILFTDLVTEYII | 183 |
A0A3B5YRG0 | 3.2.1.52 | ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MPPKLLTRLILALVAVAVAVSGAAAARRHPAPANFTASGNPVYIWPLPKNFTSGTQTLAVDPDLALDPKGAGGGAAAVAEAFQRYRHLIFSPWAHAARPASAGYDVARLTVVVASADETLELGVDESYTIYIAAAGGANSIVGGATIEANTIYGAIRGLETFSQLCVFNYDTKNVEVRYAPWYIQDEPRFAFRGLMLDTSRHYLPVDVIKQVIDSMSFSKLNVLHWHIIDEQSFPLEIPSYPNLWKGSYSKSERYTVEDARYIVSYAKKRGIHVMAEIDVPGHAESWGNGYPKLWPSLSCTEPLDVSSNFTFEVITGILS... | 170 |
O67655 | 1.1.1.37 | ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00487" | MRMKKTVAVIGAGNVGEHVASLILLKNLANVKMFDLPRKTEEKVFEPVKGKALDMKQMLAAMDIDARVEGYTVTPEGEGYEPLEGSDIVVITAGFPRRPGMSREDLLEANIRIISVIADRIKRYAPDAIVIVVTNPVDVMTYVAYKLLNFPKNRVMGMAGVLDSARFKTFISEELMVSPKDIHAYVIGGHGDEMVPLISISNVGGIPLKDLLPKEKLEKIIERTRFGGGEIVNLMGTSAYYAPAAAIVDMIEALVQNSKRILPCSVYLDGEAGEYYGVQGFCVGVPVKLGSNGVEEIIKVPMIEEEREMWRRSVESVKKT... | 5 |
B4FYH1 | 1.11.1.7 | ACT_SITE 109; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSKPAAALVMLLALVAAGPAAGDGGSTRLGCFVGWSPLKTVSSLLCLLQGSSTFPSPKPAPTGQGLSVGYYNKSGSCPKAEQLVREAVTSATNGANRGLNAGLIRLHFHDAFVRGCDASVLLDKTASNNTDTEKTGPPNKDSLRGFEVIDAAKAAVEKECPGIVSCADILAFAARDASYILSNEKIYYEVPAGRYDGRESFADETDQLPGPGSSVQDLKKSFAAQGLSLADAVTLSGAHSIGLARCLFFKDRLSAMDPGYAATLNATCNAGGDSYKVNQDYKSPDVLDNQYYKNIDKFVLFASDAALKSSETIDQVNANA... | 14 |
Q7NLT1 | 5.3.1.1 | ACT_SITE 94; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MRRKVLAGNWKMYKTRGEARAFLEAFVPLISPGAENREVILCGPFTCLDLLSAQAGPYAVGAQNVHWADHGAYTGEIAPQMLVELGVHYVIVGHSERREYFNETDSTVNRRLNNAQDHDLVPILCVGETESVRKDGITEAHIRSQLDRDLELVDMRRLIIAYEPIWAIGTGKTCEANEANRVCAMIRKHVNFEGVPILYGGSVKPENIDELMAQSDIDGVLVGGASLEAKSFARIVNFEV | 213 |
Q9I3D5 | 1.3.5.1 | ACT_SITE 289; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MASIRTLSFDAIIVGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDYIGDQDAIEYMCSVGPEAVFELEHMGLPFSRTETGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKNGTSFLNEWYAVDLVKNQDGAVVGIIAICIETGETVYIRSKAVVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIEMWQFHPTGIAGAGVLVTEGCRGEGGYLINAHGERFMERYAPNAKDLAGRDVVARSMVKEVLAGNGVGPNKDHVLLKLDHL... | 28 |
Q6CGC9 | 2.3.2.26 | ACT_SITE 838; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MFTNFTGDTRRARQVNLGGRGRQTANRESLLKKAADDRRKREEARKQDEAAKQIQLYWRKQVQEVRPKRLALKEKWLQSPDSVQEAIYFWRTLNMEEAKIVLQQCSELNAAPEQWSELGEEVCKWIISNGHKNASTILSTIAQYPVIIPSFFKAARVSEVTPEALNQQGRRNPAGFVLDYMTQEVNWQGIDLINVVLDTICKFARLPKNKAVGILSNMTQIGGDKFIPALSVVLSSVPFGDIPEELLERLEPLYSVNFVTQILDKYNYTDVSQVLVSLLRIHPERKQQVLQQLSLIDNPPVARVLWKSLFESGPIQKLYR... | 65 |
Q8A9I3 | 3.1.3.3 | ACT_SITE 201; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 203; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MQPSNTELILIRVTGEDRPGLTASVTEILAKYDATILDIGQADIHNTLSLGILFRSEERHSGFIMKELLFKASSLGVTIRFEPIGTDQYENWVGMQGKNRYILTVLGRKLSARQISAATRVLAEQDLNIDAIKRLTGRIPLDEDKTDTRTRACIEFSVRGTPKDRIAMQERLMQLASEQEMDFSFQQDNMYRRMRRLICFDMDSTLIETEVIDELAIRAGVGDEVKAITESAMRGEIDFTESFTRRVALLKGLDESVMQEIAESLPITEGVDRLMYVLKKYGYKIAILSGGFTYFGQYLQKKYGIDYVYANELEIVDGKL... | 147 |
Q59S66 | 2.7.11.1 | ACT_SITE 365; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MMLPRNSPHRTESTLAYNNNNSNNNNNNNGSSLFQRKPLAPINSEFKISKPQHIKPTTHSHTFTTPTPKTRNTATTTTNNNNRNNHQYRNPNLNTSLVFTPTKNSSSSSSSHSSSLLSSSPFVEEPENQPESNHTRATSHYRTTSTSQYKSSANKDASHSLITSSKRKTSTKQTSESTNPKRRTTTTATQNTNNNKILNPSLSSSTIRFSTVSSSTSSSTTSSSSSSHTSPKPQQQLTLDDFEFGKILGKGKLGRVYCVKHKQSGLIFALKVMSKSEIMNLKLEKSLRREIEIQSNLYHINITRLYSWFHDSINIYLLLE... | 99 |
A0A9J7KWM7 | 2.7.7.7 | ACT_SITE 341; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MGDRKRGLPQDSQQPDTKRKKSLPTCGPKSAKATSSVDQNVPKIFQDVRAFILPAGLGKARMDIFKRQIPRFGGDLHGQISSTTSHIVVDDNMEYDRLCRILKVEKPPVHASVVHANWVSDCIESRTLLGTDEYTIKVPASVTLIPQKKTTSEDEKESVSKSEGRSQATGQSDLPVQKVDDEGDQKDSGVESAATSQPSPAKDAWWWRKNKTKVPTGEDSDDSSYIPTDEDEDEEDAGNQLQEVESSPSTSASSTPNTSPQKLPRGKWVCAEPSTSKGVNYNKHITDKFQLLAKAYKNTSDQWRALSYTKAIAILQRHPK... | 121 |
A0A8I3NRW3 | 2.1.1.33 | ACT_SITE 303; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MRSRPSRSRPPSDRAGRARGTGETSEGLAIGSGPRGPLTCGVHRCLRLGQQRRPRGSAPTEAARCPVGPWQPTGDPRRGGALPPRPRPRPRPAGRTHSWVFKRRGPPPTCRGASSSCASGLGLHVGSEENPGLGIMAGAETGGAAGDGAGAEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNKTHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFRKGQLTKMFFLFPDPHFKRTKHKWRIISPTL... | 45 |
P36582 | 2.7.11.13 | ACT_SITE 789; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVQLDDALQDAYKKVEREESLILGAKAMVASTKNPEVKRRLESNIAVSENNIKYLRERIDALKVESGSERESQSDKDSSKKYSDSAKSTNSDDHLLSYNRSAFDLFNSEKPLSPEKISTMLQHLQMRLSIEQQCVSGIEKIMSLYSKEQKDKTDVIIKLKEGKQKVNLLKRSLKRYNELHIPFDISTPSSEEKQQASGLNFRGLAKPISGTLKVTIHSLRNIEHTSFLQTHSFTMPSYAVLYVDDAQVAKSRISQTDTWDETFIFDVHRAKEFQIIIYEKKKDFDIPIALILIPTTIIAEELRRKRNIQEMSETSWKPSI... | 100 |
Q9K3T8 | 3.1.1.29 | ACT_SITE 28; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MDVTTDAGAPWLVAGLGNPGPEYASNRHNVGFMVADLLAERIGARFKRHGKAQAQVVEGRIGPPGPANRRVILAKPMSFMNVSGGPVTALRDFYKVPVGNIVAVHDELDIDYGVLRLKLGGGDNGHNGLKSITKSLGADYHRVRFGIGRPPGRMPVADFVLRDFSSTERKELDYFVDRAADAVEALVIEGLERAQSAYNS | 127 |
A7ST16 | 2.7.11.23 | ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1" | MAAKVERSKRYKKIDFLGEGQFATVFKAEDQETGNIVAVKKIKLGNRAEAKDGINRTALREIKLLQELSHENVIGLLDVFGHKSSISLVFPFMETDLEVLIKDTCIVLSPADVKSFTIMTLKGLEYLHSHWILHRDMKPNNLLLDDKGVLKIGDFGLARAFGSPSRVYTHQVVTRWYRPPELLFGARIYGTGVDMWAEGCILAELLLRVPFLPGATDLDQLSRTFQTLGTPTEETWPGMTSLPDYVEFKPFPGIPLKDIFSAAGDDMLDLLDRLLDCNPNGRVNATQALNMPYFSNKPAPTPPHLLPRPKSSGKVTKKEE... | 103 |
A0A072VKX1 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MANKPRSNSSFLFLLLILHFNMGKSQLQLNYYSTSCPRAEEIIKQQVTELYNQGSTAISWLRNLFHDCMVNSCDASFLLATWRGVVSEQTSVRSFGMRNFKYVNTIKAAVEKECPLTVSCADIVALSARDGIAMLGIPNIEMKSGRRDSKESYVTVVEESIPSHNASMSLVLTRFQAIGVDVEATVALLGAHSVGRVHCINMVHRLYPIVDPTLDPTYVVYLKRRCPKPNPKAKAVQYVRNDLKTPLIIDNNYYKNILQHKGLLTVDEELATDPITSPYVQKMADDNGYFNDQFSRAVLLLSENNPLIGDQGEIRKDCRF... | 14 |
Q81J01 | 2.6.1.16 | ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 595; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164" | MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVAASVGIGHTRWATHGVPSKVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGLLDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDASDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELNQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPV... | 81 |
A0A1D8PMZ8 | 4.1.1.50 | ACT_SITE 81; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 95; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 289; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MVAPALIYSNHELSTAIDSTHAFEGPEKLLEIWFYESKELSPINLRDIKFDTWIEILNLVHCEVLSKVSSNLCDAFLLSESSLFVFPHKIILKTCGTTTTLACLDLLFETVNKELLQNEGLKATFQSKNIYQIFYSRRSFMFPDRQIHVHGNWQEEVKLLNQYFNNGKSYIVGNNTNWHLYVGGNGKTKNPVASTTTTTTPVVNDCTLEIIMTQLSLEASQQFYTTRKPGDTAIDSNHDLGHDLGQEILKQTGLNELFKFKKQPTMPGLSSSPIKEIHDGFAFTPCGFSSNSINESDYYTIHVTPEPGWSYASFETNMIG... | 196 |
A0A2R6X6V1 | 3.4.19.9 | ACT_SITE 155; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 267; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 267; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MERSSVSPCRVLLLVLVSQIFLHDTVFGGRIRMPSERLGFDDGSVVRATQPLIGILTGEMDDMIGGFGTYHPGMSYIAASYVKFVESGGARAVPLLHNEPVESLRRKFSVINGLLLPGGDTNMDGGPFLDTVKLLLDWAIEANDKGDYFPVHGTCLGMEVLANVIAQRNMMESCIAKKTPATLQFIDESKKSKSFFKWVPEDVLEKIPTVPLTIMNHKMGITPATFASTKPLADFFEVLTLSPDDYGQMYVSSVQGKKYPVTATMFHPEKNMFEWTYNTIPHSAAAIQLSQSIADYFISEARKSSHAPSSQDEVNNLLVN... | 176 |
Q5KEK1 | 2.3.1.48 | ACT_SITE 514; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MQTPAHHGHRLHGHGAVIREDFCSFCGGTDAINKQGVQETMVSCAACGRSGHPTCLNMLTPKLRKRVMMYDWHCIECKTCEQCAIKGDDSRLMFCDTCDRGWHSYCLNPPLAKPPKGSWHCPKCLSPPAVSSGSISNPRSATRPSKLHPRPSKPGKARPANTPNTSNNRRRPKQSLAGDDALFTSHRIKVKVPNPNYQYRDSEEGRGTPMIVRLKVPKRPVEEEPEEKKIPYGGVITGDDADTTRTKITEADKEAYQMAKNAAEKQLGGPVPTRETPGPGSPLPMASPSGKTTPSSKFPATSRPLRDRLLHQTLPDAYPF... | 61 |
W5N0P5 | 2.7.10.1 | ACT_SITE 841; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MQFEIAIVLSSLLTLGCCSIQDKRVCQGLSNKLTLLGTSQDHYNNIVRMYSNCTVVMENLEITYVEKDYDLSFLKSIREVGGYVLIALNKVSRIPIDNLRIIRGHILYQNSYALAVLSNFDKQSSVNKNQSSNVGLQELSLKSLTEILKGGVKFTGNPFLCNAETIQWYDIVDKSKNPEMFLIFANNTLNCKKCDPNCFNGSCWAPGPSNCQTLTKLNCAEQCSHRCKGPKPSDCCNEHCAAGCTGPRSTDCLACRDFQDEGTCKQVCPQLMLYNPNTHQLEMNPDGKYSFGATCVKSCPHNYVVTDHGSCVRTCTANTH... | 97 |
A8ICG9 | 1.1.1.37 | ACT_SITE 198; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MADPLNRIQKIASHLDPAKPRKFKVALLGAAGGIGQPLSLLLKMSPYVSDLALYDVANTPGVAADVSHMSTAARVRGYLGPDQLGAALTGAALVIIPAGVPRKPGMTRDDLFNINAGIVRGLAQGIAQHCPAAWVAIISNPVNSTVPIAAEVLQKAGVFNPAKLFGVTTLDVVRAEAFIGELTGTDPRDVHVPVVGGHAGVTILPLLSQARPPLPASMSAEARKALMVRIQDAGTEVVQAKAGAGSATLSMAYAAARFADSCLRAMSGEGPVSEYAYIRHPPRLSSGSGSSVAVDLPYFSSPVRLGRLGVEEVLPLGPMD... | 5 |
O59868 | 7.2.2.10 | ACT_SITE 329; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250" | MSVQYDAFSVEQTCADLETDMYNGLSSLQEITRRNKVHGDNDLKVEDEENMVVQFLKQFVKDPLILLLFASSAISVTLGNIDDAISIALAIVIVVTVGFVQEYRSEQSLKALNNLVPHYCNVIRSGKTEHIVASKLVPGDLVILQIGDRVPADLRIVEATELEIDESNLTGENSPRKKSSEAISSNISLTERNNIAFMGTLVRHGHGRGIVVATGSDTEFGRVFLTMQQTEKPKTPLQNSMDDLGKQLSLISLIGIAVIVLVGFFQGKNWLEMLTIGVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIIRRLPSVETL... | 258 |
E9FWC0 | 2.1.1.33 | ACT_SITE 137; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MASLPQKKYYRQRAHSNPIADHCFDYPVSPNDMKWDELYPTFSKDGIMKHKVQFADIGCGYGGLLISLSTVFPETLMLGMEIRLKVSEYVQDRIKALRILHPGDYGNVACLRSNAMKYLPCFFDKGQLTKMFFLFPDPHFKKAKHKWRIINDTLLAEYAYVLAEGGLVYTITDVKDLHEWMVMHLDQHPLFKRLTQEELDQDIVVPKLYESTEEGKKVTRNSGDKFLAVFRRIPDPFVLEENKC | 45 |
A0A7M7PKH2 | 3.1.1.4 | ACT_SITE 80; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 134; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MDLIMNSFLTLIIINVCLLFGIGQADLVHRRRPRAIWQFSSMIECATGRPALHYNNYGCWCGLGGGGEPVDEVDKCCRSHDECYDYLTEEGTCSILSLYLTSYLYERRHCQEMEEPSISCGEGSPCRTGLCDCDREAALCLAHAKYNDHRHNYDKDLCIP | 130 |
A0A1D6EBX4 | 3.2.1.1 | ACT_SITE 193; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 218; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MGQMISGDKSDEQTARDDGIIKNGREILFQAFNWESNKHNWWSILEEKVTDLAESGFTSVWLPPPTQSLSREGYLPQNLYCLDSCYGSLHELKLLLHKMSEHNVRAMADVVINHRIGTTQGSNGMYNRYDGIPVSWDEHAVTSCSGGKGNKSTGDNFDGVPNIDHTQPFVRKDIIEWLIWLRKSVGFQDFRFDFTKGYAAKFVKEYIEESKPLFAVGEYWDSCEYSPPDYRLNYNQDVLVSFCLPDIHRQRIINWIDNTGGLCAAFDFTTKGILQEAVKGELWRLRDSEGKPPGVMGWWPSRSVTFIENHDTGSTQGHWP... | 157 |
A0A1S3Y577 | 3.5.1.2 | ACT_SITE 149; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 254; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 256; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 297; /evidence="ECO:0000256|PIRSR:PIRSR036936-1... | MEAASFTSTSQFLTAKSSSSSSSSTTSYPSFSSTSQSLYSLRYKPHAKALNCKSSRSFSVRASAGGADDSVVTLLDYGAGNVRSLRNAIKYLGFDIKDVQTPEDILKAKRLIFPGVGAFAPAMDVLNKKGMAEALCTYIEQDRPFLGICLGLQLLFESSEENGPVKGLGLIPGVVGRFDSSKGIRVPHIGWNALDIAKDTQILDDIGKSHVYFVHSYRATPSDDNREWISSTCKYGDNFIASIQRGNVHAVQFHPEKSGDVGLSVLRRFLNPKSGRTQKLVQGNASKLAKRVIACLDVRTNDKGDLVVTKGDQYDVREHT... | 181 |
A0A9J7MHV0 | 4.1.1.17 | ACT_SITE 373; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MKTHIMNKDLSMEVLRDGLTARDVLTNKVNSGGRDDKDDAFFVCDLGDVVNKYKKWVSCLPRVEPFYAVKCNDSPHVLQVLANLGTGFDCASKTEVQTVLNLGVAPDRIVYANPCKQTSHIRYAKKNSVDLMTFDNEDELHKIKNYFPDARLLLRILPPAAEAQCQLGMKFGCHPSQAPKLLEVAAQLDLSVVGVSFHVGSGCLEASAFARGVESAKRIFNIADQYGFDFDMLDIGGGFPGQESAAISFDEIVADLGPALDEHFPPASGVRIIAEPGRYFVASAFTVAVNIVAKRMVARDIQEFKDEEAEDAVMNSVAPS... | 195 |
G7P9I7 | 2.7.10.1 | ACT_SITE 1111; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1" | MKSGSGEGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMY... | 97 |
Q7NCJ1 | 1.3.5.1 | ACT_SITE 277; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1" | MLEYDIVIVGGGLAGSRAAVEIARTDNRLKVALVSKVHPIRSHSVAAQGGIAAALQNVDPQDNWLTHAFDTVKGADYLADQDAVAVLTQQAPQVIIDLEHMGVLFSRLPDGRIAQRPFGGHTHQRTCYAADKTGHAILHELVSRLFQYKVPIFEEWYVLELIVEEGEARGLVMFHIPTGRIEVVRAKAILFATGGYGRVFNTTSNDYASTGDGLCLAAMAGLPLQDMEFVQFHPTGLYPVGVLISEAVRGEGAHLINDAGERFMAGYAPSRMELAPRDITSRAIATEIREGRGVGGGRYVHLDLRHMGKEKILERVPFAH... | 28 |
A2DXX8 | 2.2.1.1 | ACT_SITE 407; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MEIDELCVKTLRCLVSDMIHNARSGHPGSALGLAPALHILFSKFINFDKKWINRDRFLLGPGHASTILYAILHLYTGNLKMEDLKQFRRYGSLTPGSPEASITEDIEVTTGPLGLSVGYAAGMGCAEAHLEARFNRPNFPIFNHKVFAVISDGEMMEGPQAESASWIGHQRLDNLVCIYDSNNITINGTTDIAFTEDVMKRYEAYGWKVLEVKNGNTDLKEIENAIKQAIEIKGYPVLIKLNTTIGYGSDDANTTKIHGTPFNDEEIKKLKQNLGADPNATFFVPQEVYDYYKQIRERTQQKVEQWNKMFAEYKNQYPKE... | 51 |
A0A022RNH5 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATLNHTFIVLLLPLLLQFYSVKSELQLNYYSKSCPRAEEIIKEQVAILYRKHGNTAVSWIRNLFHDCVVKSCDASLLLDTVVGVTSEKTAARSFGMRNFKYIDTIKDALEKECPLTVSCADIIALTARDGAALLKGPEIKMKTGRKDSKESYAAVVDKLIPNHNDSMSLVLSTFQSIGIDTEGTVALLGAHSVGRVHCRNIVQRIYPTVDPSLDPQYADYLKFRCPSPNPDPKVVDYVRNDLETPMELDNMYYKNLLSHKGLLLIDSELVSNPTTYPFVVKMAADNAYFHDQFSRALLILSENNPLSGDQGDIRKDCRF... | 14 |
Q2NS86 | 2.2.1.2 | ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MNQLEGLKQFTTVVADSGDIESIRHYTPQDATTNPSLILKAASLTAYQPLFEDTLAYARKQGGTRETQIINASDKLAVNIGVEILKSVPGRVSTEVDARLSFDRGMCVAKARKLVALYQEQGIDKSRILIKLASTWEGIKAAEELEKEGINCNLTLLFSFAQARACAEAGVYLISPFVGRIYDWYNQRKPLDPYVADEDPGVVSVRKIYDYCKQHRYQTVIMGASFRKVEQILALAGCDRLTISTTLLEELHKADTRVERKLSPSTEGFHQPAPLSEPEFRWEHNQDAMAVDKLAEGIRQFAVDQQSLEDLLAAKL | 52 |
B8BQI4 | 5.1.3.15 | ACT_SITE 155; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 253; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | SADAETASSAGLMTNDDGLEYVRLSNAAGDTSDIYLYGGVVTSYVKGGQEYIAVRPDAKMDGSKPISGGLSHCWPQFGPGEIQQHGFARNVNWTVKSMDDTSCVLEMAPSDYTKEMWDKEFLCTFSVNLEDDQLSTKMFVENKGEESFDFQAALHSYFTVSALENLSIAGSFAGKEFLNKMVGDGEMQTEERDVITISEEYDRVYTGVNDPVLQDKGTGKSLSVLNTAGYEDTVLWNPYGNEGMGYNNFVCVESVKFDPVTLAGGASWTGDMALKVGDL | 210 |
A0A2C9U9W0 | 3.1.1.11 | ACT_SITE 369; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGLLHLIVFWLLGSALEATVSCGAVNFQARIQSECSFTRFPSLCRNTLMELRDHSTVHVVSALVNKTISETRLPSSYFQTLSSQLETHDAHLAKSVTGYCENLMKMSLKQLDKSLLALKESPKKNKNDIQTWLSAALTFQQACKDSADSLGLPAGEVNSQISSKMDYLSQLVSNPLALVNRITSNSVKLKNNTRTRHLGEEVEDFPKWVSARDRKLLQSGTIKANAVVAKDGTGNYKTISEAIEAASGGRFVIYVKSGVYKEKIRTNKDGITLIGDGKYSTIITGDDSVTGGSSMPASATFTITGDGFIARDIGFHNTAG... | 125 |
B8CAQ2 | 3.4.19.12 | ACT_SITE 108; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 183; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSDGNNDWCTIESDPGVFTSLIESFGVKNVELSELWSLDDESLLSLTNPMEGVENASVHGLIFLFKWQSSHAGNTNDNSPEEETGKALVGEDVPNDLFFAKQVTHNACATQAILSVLRLVLGSTLSNFKSFTSHFPPDLRGEAIGSSDEIRTAHNSFGRAEDAFLSDPSKPKRIATDDDDVFHFVAYVPNDKDECVYELDGLKEGPIRVGSYKKEGEDGNSTLQWVQVARDSIQNRLSHYSPTEIKFNLMAMVQDRRTYLTERLNSLAAIGIEESDPAMLTVRSELHLEEEKRARWEIENERRRFNYLPFCVELLRSLAG... | 175 |
O13839 | 2.7.11.1 | ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNIVQYCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENAPACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVFTQSYVGTPYYMSPEIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDIRSKLESERVVLEQSDLLHKKHQMLIQLENDLQFREQ... | 99 |
Q93IN2 | 2.4.1.12 | ACT_SITE 313; /evidence="ECO:0000255"; ACT_SITE 457; /evidence="ECO:0000255" | MSALSRWLLIPPVSARLSERYQGYRRHGASPFSAALGCLWTILAWIVFPLEHPRWQRIRDGHKALYPHINAARPRPLDPARYLIQTLWLVMISSTKERHEPRWRSFARLKDVRGRYHQWMDTLPERVRQKTTHLEKEKELGHLSNGARRFILGVIVTFSLILALICITQPFNPLSQFIFLLLLWGVALLVRRMPGRFSALMLIVLSLTVSCRYIWWRYTSTLNWDDPVSLVCGLILLFAETYAWIVLVLGYFQVVWPLNRQPVPLPKEMSQWPTVDIFVPTYNEDLNVVKNTIYASLGIDWPKDKLNIWILDDGGRESFR... | 70 |
I1HSD2 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALDVVLVRLLIIAAVASVLPARGRADGAAGLAIGFYNEKCPGAEDLVLEEMRDIVHEDRTLGPALLRLLFHDCFVRGCDASIMLKSRSKKGERDAKPMSYSLRGFDEVERIKAKLEEACPLTVSCADIIIMAARDAVYLNNGPRFPVETGRRDGKVSNCVDAENDLAPPNANIVDLKTYFSVKNLSWKDLVVLSGSHTIGSSQCAAFAGDRLYNHSGKGMQDPTLNKTYAPDLRMMCEAGNETDTTPVSMDPGSPHEFDLSYYRDVYSNKGLFVSDQALLDDKLTHDYVARMAAAPSPDEFFDDYAAAMINMGRMEVLT... | 14 |
A0A9R0KC77 | 3.4.19.12 | ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 122; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 137; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MEGPSNGGMLYHEVQEAKLCAVHCVNTVLQGPFFSEFDLAALASDLDRTERQMMTQNSVGAGDFGSAESHNVSLGGDFSIQVLQKALEVWDLQVIPLDSPVAEPAQVDPELENAFICHLQDHWFSIRKVNGEWYNFDSLYAAPEHLSKFYLSAYLDSLKGAGWSIFLVRGNFPKECPLSSEASNGFGQWLTAEDCVRILKACNSKGESSRAVDPVRREPSDQFPSLSDAQLLAMEDEDLKAAIAASLMDSTPSIPNSDSSDPSTEKSS | 175 |
F4PCH9 | 2.7.11.1 | ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MATSYTVHGRPPVQVQIKSQSSVNTKLQQHLAAVGSLERQLKAIEVTDKENTIPTSDKHKSESSKPDTLKLHPQLAATVDQERTRQKPGVPDPDQRKWSLSDFDVGRPLGKGKFGRVYLAREKHSGYVVALKILFKSELSEAKVEKQLRREIEIQSHLRHPNILRLYGYFYDSKRVYLILEFAAQGEMYKQLRKLTRFPEPQAAKYISQMANALAYLHRKHVIHRDIKPENLLLGLKGELKIADFGWSVHAPNARRQTLCGTLDYLPPEMVEGKDHNEKVDLWSLGVLCYEFLVGVPPFEDQRSYKETYRRIAKVDLHVP... | 99 |
K3XJ87 | 1.11.1.7 | ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARAGTSRAAAAVALVVAVLCASAAAEAGITRPPPVARGLSFNFYKKTCPNAEALVRGFVHDAIQRDVGLAAGLLRLHFHDCFVQGCDASLLLDDEHGEQKALPNLTLRREAITAINDIRDRLDKACGGPVVSCADILTLAARDAVVERGGPRYKVPLGRRDNVNFASHDEVNKGLPSPDANVGAMLEVLRKGNLGLDATDLVALSGAHTIGLSHCTSFENRLFPRQDSTMDAAFAAQLKQTCPAKGVSRTTPLDVRTSDVFDKMYFVNLVNRQGLLTSDQDLFTEARTRPAVQRFARSQNAFFRQFRVSMVKMGQIKVL... | 14 |
A0A1L8F4K7 | 2.7.10.1 | ACT_SITE 1141; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1" | MDRQGFLLVTSLKGLLLILLVFHANGDSTHLCGSMNIRNDVSQFRKLENCTVIQGNLQILLMFGTKPEDFRGLRFERLTMITEYLLLFRVYGLESLRDLFPNLSIIRGTDLFFHYSLVIFEMPHLRDIGLHSLTNILKGDVRIERNQELCHISTIDWSLLSESVENNYIVGNKPVEECADVCPGIRDFGESCVKTHINGHVESRCWTSTSCQKVCNCGKDIACSNTGECCDPECLGGCNKAGDPRACVACRNFYIDDQCLPSCPPGTYEYEGWRCIKEAYCGNLRKESESSQESTKFVIFENRCLSECPPGYTRNDSSIF... | 97 |
K3XX03 | 3.2.1.1 | ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MGMGSRHMCCLSTLLLLLGLSSGQVLFQGFNWESSKQTGGWYNNLMGKVDDIAAAGVTHVWLPPPSHSVSSEGYMPGRLYDLDASKYGTAAELKSLIAAFHDKGVQAVADIVINHRCADYKDSRGIYCIFEGGTPDSRLDWRAHMICRDDAKYSDGTGNLDTGADFPGAPDIDHLNDRVQRELTEWMLWLKSDLGFDAWRLDFARGYSAEVARVYINGTAPSFVVAEIWDKMVPAGDDGKPAYDQDPHRQALVDWVDKVGGAASPATVFDFTTKGILNAAVEGELWRLIDTEGKAPGVIGWWPAKAVTFVDNHDTGSTQA... | 157 |
A7EZS5 | 3.2.1.23 | ACT_SITE 184; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 283; /note="Nucleophile"; /evidence="ECO:0000255" | MRLLNIFTTLCLLLWSGAATNDGLTDVVEWDPYSLTINGDRVFIYSAEFHYQRMPVPELWLDIFQKFRANGFNTISVYFFWSYHEASKGSFDFETSGKNVQRVLDYAKEAGIYVIARAGPYCNAETSAGGLALWGSDGSMGTLRTNNAAYYQSWQPWIKEIGAILAKNQVTNGGPVILNQVENELQETVHSATNTLVLYMEQLETAFRAAGITVPFSHNEKGQRSQSWSTDYENVGGAVNVYGLDSYPGGLSCTNSNSGFSVVRNYYQWFSNYSYTQPSYFPEFEGGYFTPWGGSFYDECQSELDPSFPDVYYKNNIGQR... | 163 |
B7P6Q5 | 3.1.4.11 | ACT_SITE 328; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 375; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MTKAYDFNWQRTIPDALLKGCIFDRWEEEKEQVVYEPGALFRVDEYGFFIYWNSEGRDGQVLELSQVNDIRAGGIPKDVRLLAELSSKNRYGLDEVSLTICSGTDMVNINYTHVVCPDPDTAKVWQAGLRSITNNIKANNVCPATCLEKHWIKLGFLVEPEGKLPVRRIAQTFASGKTEKLVYQCIADVGLPGGKNDVIEPKEFTLEKFQELYQRVCPRNDIEELFNTITEGKTDYITLKQFISFLNEKQRDPRLNEILHPFYDERRVREIVGAYETSPELVKEGRLSQGGLVRYLMSDENAPVFLDRLDMYMDMDQPLS... | 153 |
A0A078FT38 | 3.2.1.1 | ACT_SITE 221; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 246; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1" | MDEKYRQFTTEQQHGLSECKTTLLFPPRLLPHLHGFHLVVSGEHIHHIGFKWESWMKEGGFYNSLHNSIDDLSNSGITHIWLPPPSQSVSPEGYLPGKLYDLNSSKYGSEAELKSLIAALKQKGIKAVADIVINHRTAARKDDHCGYCYFEGGTSDDRLDWDPSFICRGDTNYAGTGNPDTGEDYKPAPDIDHLNPRVQKELSEWMNWLKSEIGFSGWRFDFVRGYAASVTKSYVQNTSPDFAVGEKWDDMKYGGDGKLEYDQEEHRSGLKHWIEEGGGGVLTAFDFTTKGILQSAVGGELWRLKDSQGKPPGLIGIMPG... | 157 |
F1QAH4 | 2.7.11.30 | ACT_SITE 372; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1" | MGLWTRTSALLCCFCLLQVQSLSPIKTNLCKWCDHSSPVCEDNVCMSNCSLTSYCFLAEEVCVAIWKKDNVSVSVRTLCYDPQHMLENIMLANYSSKECLMSPHPSEDGLLFICSCVGDQECNDRLIFDKGPNGFSKLKSKDVIPVVVISLVPPLLVAVIATMAFYLYRTRQPGKKPKEWGPRRTHYQSLDPAEGQANGIDFSAKRPSLSDDINSEMSSTCANNLNHNTEQLPIQLEALVGKGRFAEVWRARLSHNESGQYETVAVKIFPAVEYSSWCNERAIFSDANLKHENVVQFLTAEERGGTSATSQRQYWLIMAY... | 106 |
A0A9R0JWY5 | 3.1.1.11 | ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MIILRVVVFSLCVLCVPLAEANQNDASITTTNVKLRVGEKEFFEWVNKIGFKTKSRSNKHKHNNNNNNNNNNNRMKFEQHKQQQKKKMKPCKTIKVRENPKPSSKHFGSVQKAISSLPILNSCRVVISVGPGTYREKVEIPRTMAYIKIKGAGADKTIIEWDDTADRLGQSGQPLGTYGSATFAVNSPFFVAKNITFKNVAPLPQTGALGKQAVALRISADKAAFIGCKFIGTQDTLFDHIGRHYFKDCYIEGSVDFVFGNGLSLYNACHLHAVSNHYGALTAQKRESFTEKTGFSFVNCRVTGSGGLYLGRAWGTFSRV... | 125 |
A0A1Z5RCU2 | 3.2.1.14 | ACT_SITE 90; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MRAPAAVMAMVAIFAMSTSTAGGSVASIISESLFNQMLLHRNKPACPASGFYTYSAFVAAANSFPGFGTTGSPDAQKREVAAFLAQTSHETTGGWASAPDGPYAWGYCYKEEKDAAASAPEAYCRPSALWPCAAGKKYYGRGPIQISYNYNYGPAGEAIGAAGILDDPDLVATDATVSFETAVWFWMTPQPPKPSCHAVVTGQWAPSPADTAAGRLPGYGVVTNIINGGLECGHGADSRVADRIGFYKRYCDLLGVSYGNNVDCANQRPFNSGEGGHRIHLVSNTRCHGLA | 158 |
A2EDM1 | 3.2.1.52 | ACT_SITE 273; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MLYSIKPQLQFQAQLLSDYITQQTLMPVKYSGVISDKCSIILDIGYPDANEEAYKPTITSDSISINGSTEKGSFYGIQSLRKMIPVQKTPKKIKILTQEIIDRPRFSYRGLLLDVARYFRTVEEVKKFMDIMALHNMNFLHFHLTDDQGWRIEIPKYPDLTRIGSRRRQTKGDGIPISGFFTRKDILDLIEYGQSRQITIIPEIDLPGHAQSALTAYPKLGCTGGPYEVSERFEVHSDMLCYGNPESMVFIKDVLSYVMDLFPSKYVHIGGDEAEKSQWKACQKCQAKIRELGFVDDQISTKEDKLQRHLTIELSKIISS... | 170 |
A0A804HWT3 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MIASHLMELLLLIALLLFGVQLSVGSLTSNYYAAICPFAEFIVRNTVNQALRSDATLAGGLLRLHFHDCFVQGCDGSVLIDSTKDNTAEKDSPANLSLRGYEVIDQAKQMLENQCPGVVSCADIVALAARDAVFMSGGPYYDVAKGRKDGRRSRIEDTINLPPPTLNSTDLIEMFAKHGFTVQELVVLSGAHTLGAARCSSFKKRLSNFDPNNDVDPTLDSNYARMLSRSCSAGDDTQVGFDFTRTRFDVNYYYALQGRMGLLTSDQTLYTNPQTQYIVNGYAMNQASFFSDFQQAMIKMGALNVKEGNQGEIRRNCRQV... | 14 |
Q6DR03 | 2.3.1.225 | ACT_SITE 174; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250" | MARRHGWQLPAHTFQVVAITVFFLLTVAYYAFFAPFLGNKLYEYIAIGVYSFLAFSVLVLYIRCTGIDPADPGIFVKADNTPAHKSQNSNYVPENASAIDGGPYIRHGSGCCSAIGRFICGCLVIQDCRRDTQQEQSNEQEEALFCSLCNAEVRMFSKHCRSCGKCVDGFDHHCRWLNNCVGQKNYISFVCLMAASFFWLIAEFGVGVTVFVRCFVDQKAMEHLITEKLGLGFSRPPFAAVVVVCTTLSLLALIPLGELFFFHMILIRKGITTYEYVVALRAQTEPLGTSVDELDQTSQYPSPASSAVTATSARSSLGLS... | 57 |
A0A6I8NXU0 | 2.7.10.1 | ACT_SITE 727; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MERRCPPGLGLALLLLCAPLPPGVPAKEVTLLDTSVAQGELGWLLDPPETGWSEVQQMLNGTPIYMYQDCPVLGTGEADHWLRSNWIYRGEVPTRVFAELRFTVRDCRSFSEAGSGPLGCKETFNLFFMESDQDVGIQLHRPLFQKVTTVAADQSFTVRDLAIGAMRLNVERCLLGRLTHRGLYLAFQNPGACVALVSVRVFYQRCPEIERGLARFPDTLPSPVGLTEVSGTCLPHAHPSLDPGPRMYCSPDGEWLVPVGECHCGAGYQDEEGECTACPRGFYRPDSDVRRCLKCPPRSSSSSEAATFCSCVTGYYRAPA... | 97 |
B1L6R0 | 6.2.1.5 | ACT_SITE 248; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01988, ECO:0000256|PIRSR:PIRSR001553-1" | MAILVREGMRVLVQGITGRQGTIHTKLMLEYGTKIVAGVTPGKSGAKVYDVPVFDSVEEAVREKGPIDASIVFVPAPYAMDAVIEAVDNAIPLVVVITEGIPVHDTAKFVSYARSMGTTIIGPNCPGIIAPGKVKIGIMPADSFAPGPVGIVSRSGTLTYEISLSLKNAGYGSSTTIGIGGDPITGLNFIEVLELFKEDPETKAVVIVGEIGGDAEERAAKYIAQGYPKPVVAYVAGRTAPPGKRMGHAGAIITAGQGTVESKERAFSEAGVPVARTPFEVAPLLAERLRH | 247 |
A0A0K9NPT2 | 3.4.19.12 | ACT_SITE 23; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 23; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 128; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 143; /evidence="ECO:0... | MDFGGSPSNGGLLYHEVQESKLCAVHCVNTVLQGPFFTELDLAALASDLDHKEREVIVSHDQDALSSHDFLSEDSHNVSMDGDFSIQVLERALEVWDLKVIPLDSPVAEPSKHDPELENAYICHLQNHWFCIRKVNGEWYNFNSLYAAPEHLTRFYLSAYLDTLKSSGWSIFLVRGNFPKDCPVSSSDPSYGFGQWLTPDDAKGITNSCNESGVTQRIESPHRIIQYKML | 175 |
A0A0Q3K0V5 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLSGNMMKGNKQLGCLVAVAVLVLSAGSLDTAAAQAAGLKKGFYKKSCPQAEDIAQKVVWNRVAGNRELAAKFLRMFFHDCFVRGCDASVLLDSPTRTAEKDSAPNLSLAGFEVIDEVKAALERACPGVVSCADIVALAARDSVSFQYGKKLWEVETGRRDGSISSDQQALDEIPAPSSTFDVLASNFSSKGLGVQDLVVLSGGHTIGIGNCNLVSSRIFNFTGKNNPSDIDPSLNPPYAKFLQGQCRRNQADPNDNTTVVPMDTGSSTSFDSHYFVNLKAGQGLFTSDATLVTNARAASLVDKLQDNGVFLDHFKNSIK... | 14 |
P25341 | 2.7.11.1 | ACT_SITE 449; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTQQEYRSPSQRLSKGRSMSLPKIFARNLRSLQNNAPPGKNINVNCLNVNSCSLSASPSSQINMACNGNKQDLPIPFPLHVECNDSWSSSKLNKFKSMFNHNRSKSSGTTDASTSEKGTHKREPRSTIHTELLQSSIIGEPNVHSTTSSTLIPNEAICSTPNEISGSSSPDAELFTFDMPTDPSSFHTPSSPSYIAKDSRNLSNGSLNDINENEELQNFHRKISENGSASPLANLSLSNSPIDSPRKNSETRKDQIPMNITPRLRRAASEPFNTAKDGLMREDYIALKQPPSLGDIVEPRRSRRLRTKSFGNKFQDITVE... | 99 |
A0A078IPB5 | 3.1.1.11 | ACT_SITE 406; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MIGKVVVSVASVLLLVGVAIGVVVIINKNGNTPLSPQMKAVQGICQGTSDKASCVKTLEPVKSDDPNKLIKAFMLATQDALTKSSNFTGKTEGELGSSISPNNKAVLEYCKKVFLYALEDLGTILEEMGEDLNQIGSKIDQLKQWLTGVYNYQTDCLDDIQEEDLRKTIGEGIASSKILTGNAIDIFHTVVSAMAKLNVKVDDFKNMTSGVFSPSDKGAAPTGLPTWVSGADRKLMANAGRGRRRGGGGARIRANFVVAKDGSGQFNSVQQAVNACPDKNPGRCIIYIKAGIYREQVIIPKKKNNIFLFGDGARKTVITY... | 125 |
P39118 | 2.4.1.18 | ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 352; /note="Proton donor"; /evidence="ECO:0000250" | MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVWAPHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRLKADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKKHSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGPPHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGTANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQ... | 73 |
O23447 | 3.1.1.11 | ACT_SITE 520; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 541; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040" | MNKYVLLGVTALIMAMVICVEANDGNSPSRKMEEVHRESKLMITKTTVSIICASTDYKQDCTTSLATVRSPDPRNLIRSAFDLAIISIRSGIDRGMIDLKSRADADMHTREALNTCRELMDDAIDDLRKTRDKFRGFLFTRLSDFVEDLCVWLSGSITYQQTCIDGFEGIDSEAAVMMERVMRKGQHLTSNGLAIAANLDKLLKAFRIPFPFLRSRRGRLGILGSGSSRDESVGSSQDSPPNEDSSDDSPSTVDSSENQPVDSSSENQSSDSSNNRPLDSSKNQQMESSEDTPKKSAFSGNQPLDDSSDKLPQKSTSSEN... | 125 |
A0A9R1XN79 | 3.1.1.11 | ACT_SITE 424; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSRTTDFFSEGLDSGMQINLSNKRKKLFLTAFALIILLASALIGVIVGVKSRNSGFDNSNPESITDSEAHAIVKSACSSTFYPELCYSTVTSHPDVTIKVKNLKNVIELAVNITVTAVEQTYFQIKKLTTRKGLTKREITALHDCHQMISETLHELLDVMKGLQKYQTKESLRHHANDLKTLMSSAITNQETCYDGFSHDEADKNVRKELEQGERRVEKMCSNALAMICNMTNTDLAEEMKLNARKLKEEVNTEWPGWLSAGDRRLLQSGTVKPNVVVATDCSGNYRTVADAVAAAPSHSRTIYVIKIKAGVYHENFEVP... | 125 |
P84155 | 1.3.3.3 | ACT_SITE 107; /note="Proton donor"; /evidence="ECO:0000250" | MSLAVEAVKDFLLKLQDDICEALEAEDGQATFVEDKWTREGGGGGRTRVMVDGAVIEKGGVNFSHVYGKGLPMSSTERHPDIAGCNFEAMGVSLVIHPKNPHVPTSHANVRLFVAEREGKEPVWWFGGGFDLTPYYAVEEDCRDFHQVAQDLCKPFGADVYARFKGWCDEYFFIPYRNEARGIGGLFFDDLNEWPFEKCFEFVQAVGKGYMDAYIPIVNRRKNTPYTEQQVEFQEFRRGRYAEFNLVIDRGTKFGLQSGGRTESILISLPPRARWGYNWQPEPGTPEARLTEYFLTKRQWV | 27 |
Q0D847 | 2.7.11.1 | ACT_SITE 181; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9JIH7" | MMGALQQQSNGHGHGVLLLAEAGYAEVDPTGRYGRFNEILGKGSSKIVYRGFDEWRGVEVAWNQVRLRDVVRGGGELERFYGEVHLLAALRHRGIVRLHAYWVDAPRRALNFVTELFVSGTLRQYRERHRRVSAAAVRRWCAQILDGLAYLHAHSPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAFRRGGGHARCVGTPEFMAPEVYDESYDELADVYSFGMCVLEMVTLDYPYSECSNPIQIYKRVISGIKPAALYRVSDPVVRQFIERCLAPAARRPAARELLDDPFLLPLEDDGFFSGDGGDGHGGFGVGYYNLMY... | 99 |
O84096 | 5.4.99.25 | ACT_SITE 45; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MELATESIEGVLLVDKPQGRTSFSLIRSLVRLIGVKKIGHAGTLDPFATGVMVMLIGRKFTRLSDIMLFEDKEYAAVAHLGTTTDTYDCDGKIVGRSKKVPTMDEVLTCTSYFQGEIQQVPPMFSAKKVQGKKLYEYARQGLSIERRFATVTVNLRLVKYEYPRLHFVVQCSKGTYIRSIAHELGNMLGCGAYLEELRRLRSGSFSIDQCIDGNLLDEPGFDVSPYLRDANGLILQPAPVL | 218 |
Q8PCF2 | 2.7.1.107 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600829-1" | MADQLGHVPRGPRRMLKAAVWSWQGLRAAWLHESSFRLEVCLAALLTPLALWLGNSGLERIALIAPLLIVLAAELLNSAIEAVIERYGPEHHVLAGRAKDMGSAAVFVLLINVLLCWGLVLLPRLF | 83 |
G1KCW7 | 3.5.1.98 | ACT_SITE 826; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MNSTNESDGVSGREPSLELLSRAQIHAIPVAAVDLKPVLPVVMQSSCNSSSSSSPVDLRMDARPSVPTIDPAAREQQLQQELLALKQQQQLQKQLLFAEFQKQHEHLTRQHEVQLQKHLKQQQEILAAKRQQELEQQRKREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLKLQEFLLSKSKELASAGGLNHSLPQHSKCWGAHHTSLDQSSPPQTGSPGTPPSCKLPLLGTYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAIEITVSSMCNSAPGSGPSSPNSSNSAITE... | 184 |
Q8EE98 | 1.1.1.49 | ACT_SITE 240; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966" | MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKDTKVIGVAKDEFSQDEYRDLVILALKTFVKEPLCEDTLNRFVSRCYYVGTNFTESAGYGAFHELLKPEERVMVSYFATPPSIFGDICRCLHEQNLIHSDSRVVLEKPIGSDLASSRIINDQVSAYFKESQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNHLLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINADNVYENTVRGQYSAGFLKGSPVPGYLEEEGANVQSHTETFVAL... | 6 |
Q8A1G3 | 3.2.1.1 | ACT_SITE 388; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 431; /note="Proton donor"; /evidence="ECO:0000250" | MNKHLHFLSLLWLSMLMAFMTACSDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGEDICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDF... | 157 |
A0A8V0Y4W4 | 2.3.2.26 | ACT_SITE 1209; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MAHRLRFHFGSGRSNTAPESEILDREREDDFFMAFHTLPRRSSPHAFSRHGADYGGGSEFQEVGSLKRSTSMFIPQLLNSISARPTRSSSMQISLQRKAADECATPETPEETPLCKASDVRERYASPVENHSSSRSSPEVTPEDSPPRQTEELGQQMNGTLRCNRRVFRTIPPNSQSDDALSTARENEAKETASGLNISGVRIQHRASSADVPQVTLLPFGSEAQNNAPTPEPRRWSLQHVPDMSANSGKKFFVLQLQQPQAGGTGGEYNFGFTGTKGDRLVRYPRIQLERSASYPVQPRPEEIRPTGDGLTSELHGNGR... | 65 |
A8X6B4 | 3.1.3.16 | ACT_SITE 186; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MSAPKLTDSQKKVRGFVNRIIGKLMFKWKHTTSMELFCAAELAELCIRARELIWAEPICLKLETPICVMGDLHGQFDDLLGMWDSNGWPLTEKERNWFMEKTLKTKRMPCTEPKSSQPDSNPNGPRSSGGWDEKPVLKEVKDLGYKRYLFLGDYVDRGMYSMEVVILLIAIKMAYPDRLYMLRGNHESRSVNCHYGFYREVTRRYDAKLYEYFSDLFNVFPFCAIIEDTIMCMHGGISEQLMNLSQLALYKRPVEIPDMGVLADLTWADPDPTVKRYAPSSRGASSVFGSQALREFLKRLNLRLVIRAHQVVEDGYEFFD... | 144 |
A8XU89 | 1.1.1.8 | ACT_SITE 231; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1" | MPCQNFDYCFNNNSDELRGDSRKKIAIVGGGNWGSAIACVVGKTVKAQDDVFQPIVSMWCRDSRKPGDTTPSIAETINATHENPKYLPGRRIPSNVIATSSLLDACESAHILILVVPHQGIPQICSELRGNLRDGAHAVSLTKGISSTSENDVIRMQLISEDIEKALGVECSVLMGANLAGEVADGKFCEATIGCKSLENGEELKMLFNTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLLETKKFVEHFYPSSHHTYFESCGVADLITTCYGGRNRKVAEAFIKSDKPLHIVEQELLKGQ... | 7 |
A0A251UPS6 | 1.11.1.7 | ACT_SITE 109; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MSTSTLSSSILFITNSNISLNHLHQNLKFQTPPESSLLPTMAAKNTTIFSFFSTLIFFGLIHSNQIDALNTNYYDHTCPNVESTITSVVKKAMMNDPTVPAALLRMHFHDCFIRGCDGSVLLNSTGKNKAEKDGPPNISLHAFYVIDNAKKALESLCPKTVSCADILALAARDAVTLSGGPTWDVPKGRKDGRISKATETRQLPAPTFNISQLQQSFAQRSLSMDDLVALSGGHTLGFSHCSSFQNRIHNFNSKQSVDPALQSSFAARLKSICPAHNTVKKAGANLDSTPTTFDNRYYKLLLQGKSIFSSDQALVTMANT... | 14 |
A0A8M6Z1G5 | 2.7.10.1 | ACT_SITE 671; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MMMKKMMKMQSSGGPAALSGCCVRWRVRCSGLCALLIAAVLRCCSANSDLRFVESPGNVTSSLGKPVSLQCVLQAFGLDEEPLDLLWLRDGRTLEYADTNQIQMLEEDHSWTVISKLTIEEVQLLDMGAYRCVLYSGEEETSSAEGYIQLEGLPHFSVEPQDRSAVANEPLSLRCEAHGPPEPVRVIWLQDGAPLNELDDPVALSPSTLNISGLNKSSSFSCEAHNRKGVASSATGVVTVLPSPPSAITADEISNSSIRLSWHSGFGGVYPISHCSVQVQDSSGSLVQDQQVSGVVGVCVISDLQAFSQYEVRLQCRSSQ... | 97 |
Q81ID4 | 3.4.21.89 | ACT_SITE 39; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 78; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MMQKKKRWREFFGTIAIACLLVFLAKIFVFFPTTVKGASMRPTLQDGDKVIVNKLAKQFESYGREDIIVMKTDNFYVKRVIGLPGDIIEMRNDQLYVNSEVKDEEYLDSNKKQAEKKLMNLTEDFGPITVPENKIFVMGDNRLISKDSRNGLGFIDREDVLGKLAGIYYPFEHMKIIK | 178 |
P54560 | 2.7.7.7 | ACT_SITE 108; /evidence="ECO:0000250" | MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGVVLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVEPYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNFAKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLLKKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLELSEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTN... | 121 |
A0A8I5ZUV2 | 2.3.2.26 | ACT_SITE 663; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPSRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLV... | 65 |
Q9RU23 | 6.3.4.2 | ACT_SITE 383; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 517; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 519; /evidence="ECO:0000255|HAMAP-Rule:MF_01227" | MKYIFVTGGVVSSLGKGVASASLGALLRARGYKVTAVKIDPYINIDAGTMRPYEHGECFVTASGAETDLDIGNYERFLDLDIPAGSNITTGQVYQEVIRKERAGDYLSQTVQVIPHVTDEIKRRIRAAGESAGAEIVLIEVGGTVGDIESLPFLEAIRQFRFDEGDDNVLYLHLTLVPYLGTSNEFKTKPTQHSVAALRSYGISPDIVMVRSKDKLPAEITRKIAAFTSVRENRVFSSYDVEHVYQVPLALEEQGLGKAVEELLGLEGTHPRLGVWTDAVRTIKHPKQQVTIAIAGKYTAMPDAYLSLMESLTHAGIAND... | 252 |
Q5JHL8 | 3.4.25.1 | ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113" | MEKKTGTTTVGIRTKEGVVLAADTQASLDHMVETLNIRKILPITDRIAITTAGSVGDVQALARMLEAEARYYQFTWGRPMTAKAMAHLLSNILNENKWFPYMVQIIIGGYVEEPTLANLDPLGGLIFDDYTATGSGSPFAIAVLEDGFRKDMSLEEAKELAVRAVRTAGKRDVYTGDRKVQVVVISKDGMKEEFVEFKE | 180 |
A5D6R3 | 3.1.4.11 | ACT_SITE 328; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"; ACT_SITE 373; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270" | MLGRKKNPETVQTESKSVESKTHDPLRRLGVLDDEDVLLMLQGSKMMKVRSQRWRKDRRLKLLEDCVTVWCESSKTSRKSNRQQTFSVTEVECVREGCQSECLRRMTDLVPEKNCFTVVFRGGRKSLDLCCHTQEEAERWVRGIRTLKDRVSNMSQKEKLDHWIRGYLRRADQNQDGKMSYDEVKHLLQLINIDLNEQYARTLFKKCDRSCDGRLDHVEIEEFCREMMRRPELDAVFRHYSGNGCVLTTLELRDFLGDQGEDASLVHAKSLIQTFELNDWAQKNLFMTQNGFTMYMLSKENDVFNPDHTHVYQDMSKPLA... | 153 |
F7DBN2 | 3.2.1.52 | ACT_SITE 300; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MNERTNGLWASPRPARDGRWQGGRQYAAGSALQPGCSVLDQAFGRYLRLLFGPGPPPRPAEAGEDQASDSTLTVSVDNPGCDGFPSLKSLENYTLNLADDQFSLKADEVWGALRGLETFSQLVWRSAEGTYFVNKTEIVDFPRFPHRGLLLDTSRHYLPLSSILETLDVMAYNKFNVFHWHVVDDPSFPFESVTFPELSRKGAYNSATHVYTPEDVKIIIEYARLRGIRVLAEFDTPGHTLSWGLGAPGLLTPCYVGPMLSGTYGPVNPILNSTYEFMAKLFSEISSVFPDFYLHLGGDEVDFTCWRSNPDIRDFMEEVG... | 170 |
F4NYD5 | 3.1.3.16 | ACT_SITE 104; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1" | MDMAVNWQYEMRRDMQEIIPGLWLGPYSCARDNSLLHLKGITHILCVRESNEEMMVRMRFPEEFHYLCIQASDSPLQNLIPLFPKATSFIHTAITNGGSVLVHCNGGISRSPAFVVAYMMDMHDMQFATAFQFVQSKRFCMNPIEVFKYQLR | 144 |
Q0V4Q5 | 2.5.1.18 | ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MSGRITSYLDCVSPYSYFALLRLEENRALLKEHNVEIDIVPVFLGGINVGSGNKPPWTLPAKGAYGRYDSERSKRYFGVPNIKTPEFFPILSLLPQRALVYVKEAHAQKFIQAFKDIFQGIWEQGLDVSKPELLAQVLSKQFSETEVRDILEKANSAPYKQRLNDNTKEALDLGAFGCPWHVLRNSKGVEEPFFGSDRFHYMWEFLGLPWKDIELQAPGSAKTKARI | 77 |
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