Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
A7S0E8
3.2.1.52
ACT_SITE 501; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
MAAKIDLRYDVISNLQGDGRYSAKLTLTNTGTTVITKGDWDLVFCSIRLIVPDSSTERAGVKVSHINGCLHKMTPLETFPVLAADQNVEIPFRAMNWVVAKTDIMPNWFFAADGLEPRVVKSTEGEGLSFVGKFTTEEQWKRYANDQYNPYTAQGRYDVIGFDDLGEDGWGDIVTIPQPMTVQGLERKSRVGIRADWKIFADGGFQKEAQLLKAKFNAQIASSMPFNQSKLIRLVKGDPNVTRGVASSEAYSLEIKVAEKEIKLTGSHASGVFYGVQTLIALADKENTVPMVTIKDAPRYGYRGMHLDVGRNFMEKAAVLKLLDAMATYKMNKFHFHLTDDEGWRLEIPGLEELTTVGSKRCYDINTTRCILSQLGSGPSPSTSAQYYSVSDYKEILKRANDLHIQVIPEFDMPGHGYAAIKSMEARFKRLKDSNPSEASKYILSDFNDTSKYLSIQYFTDNAINPCIESTYAFIEKVLTEVKSMHKDIQPLTVYHFGGDEVAHGAWTKSSACEQLAQRMGYNLTGSDIVDKLKGYFVERVANITVNDGLSLAGWEDGLLGHGEVPYNRKSFRNSNVMAYAWNNIWEWGSGKRAYLLANAGYKVVMTQATHLYFDFPYEPDPQERGYYWATRFTDTRKTFGFMPDNLFNNVEQKVTGEPLTREELCKTEGMCVELVKKENIIGMAGALWTETVRTADQMDSMIFPRLLAVAERAWHKASWEDISDKTERNNKRSEAWKRFATYLGHLEMTRLDAMKIKYHLPPPGARVENSKLKVRTAIQGLPVQFSKDDGKTWSDVTDSTEVRGKLVLRTKSADGTRQSRLVTLNMDVSVASRLSVAREKGTTKAQRVPFEKKNSPIGRQRQGKGYRKEHRSTQEINKNIRFMILESNQEFKQKFHVFNLRVQDLAREAEEKESIIRERESEISALSMEHEDALEREHQYQKELDYAWKRILRCENKIRHLIDELEFYRT
170
Q38FY2
2.7.11.1
ACT_SITE 210; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MSTRLCEPSLRDDGAQRGTPASHGKWCDTGAFKLDETPSPVVANVSSTSDASFQFNRTPSPGKHQNHAADRSMWSLDDFVIIRKLDEGRFGKVYLAREKQSKCAVVLKCISKDMIRFHSLAHQLQREVELQEYAGRYHKNVLRLFAYFWDDVRIVLVLEYADSGTLQDLLDCYREKEQRSSLPDDKVRTILLQLLSALAFLHERDIIHRDVKPDNILFHGEKLLLADFSWAVRVNNSDPRYCRRHTVCGTLDYLAPEQVLKRGCTTKADLWAVGVVAYRMLCGFLPFEMLDARDVCSCIASGAIRYPSQLSPTARHFLQGLLRVDEALRFSCQEALNHPFMRGDCNCRISNRYIESKHRARAEEPVLQHQGSFDTTKNGTRWIQQKKESWCCSRAPTLNVPEPVHHTGTNCVANHSHNHKDMDKSTTLSCPSASDIVRVRATTERVRCPVDDYSGTSASLITISPLRSTECMQSLSNVSTPSIVSQTHSEWLHSASPISHTPVVAAAATSKCSRDDVGTSSYGVSYSGIRLHNSASDGSGTTTGQHHAQLGTSTHSSFAFAPPTSARYRRDISGYHRINGRGSSPSDHEEYEVASCALRLCFDDEDDADNNCSGALHAAASNRPKTLKSGVMMNGTAPPSHHKGSSYDVR
99
A0A2K1XMN9
1.11.1.7
ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSLAISFLLLILISPSKAVLNNAHYYDQTCPQAEKIIFETVRNASMHDPKVPARILGMFFHDCFIRAWISIIQRIDDAKAKLEMACPHTVSCADIIAIAARDVVAMSGEPSWNVLTGRKNGRVSKANDTITLPAPTFNAMQLIQSFAKRGLGVKDLVALSGDHNLGFSHCSSFEARLQNFSSVHDIDPSMNTRFAGNLKRKCPKPNKDHSAGEFLDSTSSTFDNDYYKRDIEGKGIFGSYHALLGDYREFAASMVKLGKVGVIKNGEVRFKCRVVN
14
Q9XCX9
3.1.26.3
ACT_SITE 44; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"; ACT_SITE 116; /evidence="ECO:0000255|HAMAP-Rule:MF_00104"
MSNSLDRLERKLGYTFKDRDLMVLALTHRSYAGRNNERLEFLGDAILNFVIGEALFHHFPQAREGQLSRLRARLVKGETLALLARGFEVGDYLRLGSGELKSGGFRRESILADAMEALIGAIYLDTGMDSARERIIAWLGPQLRELTPVDTNKDPKTRLQEFLQSRGCDLPRYEVVDIQGEPHCRTFFVDCEVALLSDKTHGHGGSRRIAEQVAAAAALVALGVENGHD
138
Q8Y7J0
5.6.2.2
ACT_SITE 122; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_00937"
MSNPEQHIQDLALEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMNVEGNTAEKGFRKSAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNMLIEMHGNNGSVDGDPPAAMRYTEARLSPISAELLRDIEKETVDFIPNFDDTSSEPTVLPARFPNLLVNGSTGISAGYATDIPPHNLTEIIEAVIKRLDNPLCTTDDIMKIVKGPDFPTGGIIQGIDGIRKAYQTGKGRVVVRSKTEIEDIRGGRKQITIHEIPYEVNKANLVKRMDELRIEKKIEGISEVRDETDRTGLRIAVELKKDANAEGVLNYLFKNTDLQVSYNFNMVAINKKRPELMGIIPMLDAYIEHQKEIITKRSEYDIRKARARQHILEGLIKALSILDEVIKLIRGSKDKRDAKLNLQTKYDFSEKQAEAIVSLQLYRLTNTDIHELQSEAKSLAEQISVLEKILGDEAELIAVLKEELAEIKKKYKTARRTEVQAEIAEIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAELAMKEADHAIFIQKMNSLDSLLLFTSKGNFIYRPVHELPDIRWKNLGDHVSHLASDLSAGEEIRSAIAIQAFTEEKRFLFVTKNGMTKQSAITNYKPQRYSKSMMAIKLKGDDELLSVHLIDGTEDIFLATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVLMPNEQKHILLATQRGSLKQMKASEFEPISRAKRGLLMLRELKSNPHRFIGITLADNNDHLFIETNTDQIVEIDVANLRITDRYSNGSFVLDETMEGEPTSIWLAIPEIKDTSDAKEE
222
Q54TW2
2.7.11.1
ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MENIVITNTSGGGGGGVPSSSTDPPNNTTTTTATASAIDLNMSLSPFLSSPSLSSPSIQSAKKKTIEDFIIGKVLGEGSYGAVVLGTEKETQQQYAIKILEKKQIIKENKIKYVQIEKEIFCKSNHPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKVGSFDYRSCQYYVAEIISGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLPTNSSGNLSSLLNNVNNLSVSTDLTQQQQNRTSSVDSASTTDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKTTEIPKLTRNNSFVGTAEYVSPELISNKETSTDSDLWALGCIIYQMASGRVPFRGKTEFLTFQKVSNRELVYPINMNPVIKDLVEKLLVIKPTDRLGSSSTPGGFDNLKAHPFFQDFNWSSLSNMSHPPPPIQPPQEKIIFDGDELFSPSLDCTTPRNNNVDENHQQNSCNNNNNNNNNINNINNNNNSSSNNISNSNSNSNSSNNLNISNGNLSTPRSSSSSSSQQPTQRSGSSGGSRDGGSSSNNISKWLNNGENVIYQGLVWKRKGFSIKKRQLILTDTPRLIYIDPKKMELKGEIPWSDSIKPKLKSNNNFVIKTPKRKYLLEDVAHNPQKWVDSIKSVILSSGSSN
99
C5Z864
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVRRMVLVAALVVATVAVLAGGARAQLKEGFYGSTCPQAEKIVKEFVKAHIPHAPDVAATLIRTHFHDCFVRGCDASVLLNATGGKEAEKDAAPNQTLRGFGFIDRIKALLEKECPGVVSCADILALAARDSVGVIGGPFWSVPTGRRDGTVSIKQEALDQIPAPTMNFTTLLQSFRNKSLDLADLVWLSGAHTIGISHCNSFSERLYNFTGRAVPGDADPSLDPLYAAKLRRKCKTLTDNTTIVEMDPGSFRTFDLSYYRGVLKRRGLFQSDAALITDAASKADILSVVNAPPEVFFQVFARSMVKMGAIDVKTGSEGEIRKHCAFVNKH
14
Q6YXM7
3.4.21.92
ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 127; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
MPIGVPKVPFRLPGEEDAVWIDVYNNRLYRERLLFLGQHVDDEIANQLIGIMMYLNGEDENKDMYLYINSPGGAVLAGISVYDAMQFVVPDVHTICMGLAASMGSFILAGGEITKRIALPHARVMIHQPASSYYDGQAGECIMEAEEVLKLRDYITRVYVQRIGKPLWVISEDMERDVFMSAQEAKTYGIVDLVAIENT
179
Q9SR87
2.7.11.1
ACT_SITE 495; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MGIARSINSFMFFFFLMILSNASKSSVLAEATTAKFTFIGFKENQTDIQTEGASTIQHDNDLLRLTNRKQNVTGTAFYRKPIRLRELTNSSDIKVCSFSTSFVFVILPSSPGNGGFGFTFTLSPTPNRPGAESAQYLGLLNRTNNGNPSNHVFAVEFDTVQGFKDGADRRGNHIGLNFNNLSSNVQEPLIYYDTEDRKEDFQLESGEPIRVLIDYDGSSETLNVTIYPTRLEFKPKKPLISRRVSELSEIVKDEMYVGFTAATGKDQSSAHYVMGWSFSSCGENPMADWLEISRLPPPPRLSNKKGYNSQVIVLIVALSIVTLVLLVLLFIFVMYKRRIQEEDTLEDWEIDYPHRFRYRDLYLATKKFKESEIIGTGGFGIVYRGNLSSSGPIAVKKITSNSLQGVREFMAEIESLGRLGHKNLVNLQGWCKHKNELLLIYDYIPNGSLDSLLYQTPRRNGIVLPWDVRFEIIKGIASGLLYLHEEWEQIVVHRDVKPSNVLIDEDMNAKLGDFGLARLYERGTLTQTTKIVGTLGYMAPELTRNGKGSTASDVFAFGVLLLEIVCGNKPTNAENFFLADWVMEFHTNGGILCVVDQNLGSSFNGREAKLALVVGLLCCHQKPKFRPSMRMVLRYLNGEENVPQIDENWGFSDSSRDDHKSNVVGYVSSDRASSSNTFSSFSNVSSSSIVSGR
99
D7U2P4
1.11.1.7
ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATCERPGFQALAWLLCLIFAHLSASTMAFPRSSLSSSLKVGFYGSTCPSAEAVVRKTVDKAVSRNLGIAAGLIRMHFHDCFVRGCDASVLLDSTPGNLSEKEHPANNPSLRGFQVINKAKAKLEALCPETVSCADIIAFAARDGALKVGGINYTVPGGRRDGRVSRKDEVAESLPPPHFNAEQLELRFARKGLSLDEMVTLSGAHSIGMSHCSSFSKRLYSNGTHAHDPSMRRKYVSFLRTKCHPQRNGGQNPTVPLEAKTPGRLDNKYYKELEKHRGLLNSDQTLMSSQSTAWMVRNNARHGSTWAAKFAAAMVHMGSIDVLTETQGEIRRSCHVVN
14
A5F028
2.2.1.2
ACT_SITE 132; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MSNKLAQLRKLTTVVADTGEIDAIKKYQPEDATTNPSLILKAAQIAEYAPLIDQAIAYAKTQSNDKAQQVQDTCDMLAVNIGKEILKTIPGRISTEVDARLSYDMERSVAKARQLVKMYNDAGISNDRILIKLASTWEGIRAAEILEKEGINCNLTLLFSFAQARACAEAGVFLISPFVGRIMDWYKAKEGRDFAASEDPGVLSVTKIYNYYKEHGYKTVVMGASFRNIGEILELAGCDRLTIAPSLLAELEAAEGELVAKLVDSKGSKARPAPMTHSEFLWEHNLDAMAVEKLAEGIRNFAVDQGKLEAMIAAKL
52
F7A6K0
3.1.1.4
ACT_SITE 70; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 115; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MESVRLLLLLLFTTVSGKSHVHRRGLTELATTITCATKSSALVYLKYGCYCGLGGSGQPQDQVDWCCQKHDCCYKAASDAGCIPKLQTYSWNCVNNTVECASSQSKCAAIACKCDQELSHCLASAKYNKKHFLSLASDCGDQSPKCE
130
M5XMU7
1.11.1.7
ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MEMSLATIIFTFTFTFCTIFIIPCSEAAEKGQGNGLHVGFYGIRCPNAEQIVADVVSKAVEADQKLPAAFIRLFSHDCFVKGCDASILLDSTPSHEPVEIQSPANVGIKGLEVIDEIKARLEAECPETVSCADILAFAAREAVALAGLPRHKVPAGRRDSRTSRATDVTLPAPATPLNEIIEYFSRRGMTSDEIVVLSGAHSIGAVHCSFFDYRLYNYDQTQAQDPALDRFYAANLSQQCPAPNTLPEAEAKNRVVDFDPITPLVLDNQYYANLMQGKALLQSDQALVTDPRTKAMVISMAASADSWTQRFVRAMIKMGRINVLTGENGEIRKNCRAFNPL
14
M5XEJ2
1.11.1.7
ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MALVLAMALAMVLAVAQEVEGQLMVGFYGETCPQAEPIVRNVVREAILSDTNMAPVLLRLHFHDCFVEGCDGSILIENGPSGERHAFGHQGVGGFEVIEKAKAELEAACQGVVSCADIVALAARDAIAMAGGPAYEVPTGRRDGVVSNMSLADDMPDVSNSIQQLKVKFMRKGLTEKDLVLLSAAHTIGTTACFFLTKRLYNFFPGGGSDPAINPTLLVELKQKCPQNGDVNVRLPIDQGSGQAFDLHILQNIRNGFAVLESDAKLNEDAVTRGIMDNYFGFFSNLPFGPSFEADFVEAILKMGQIGVRTGFQGAPRRVCASF
14
Q9KVV4
2.7.11.1
ACT_SITE 213; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_01497"; ACT_SITE 229; /evidence="ECO:0000256|HAMAP-Rule:MF_01497"
MVKGSVMSPFYSMTQATFHFDALTPDLIWYALESIGIRAESGFLPLNSYENRVYQFTDEERRRFVVKFYRPQRWTDEQIQEEHDFALELEQEEIPIVPPLRLNGATLHHYQGYRFALFTSMGGRQYEVDNEEHLEWVGRFLGRIHKVGASKPFLHRPTLSLDEYLHQPRHTLEYSHCIPAHLQRVFFHDLDILIAEIKQHWVPTQPQIRLHGDCHPGNILWRDGPMFVDLDDARNGPAIQDLWMLLHGDRQDKLIQLDIVLEGYQEFCDFNPQQLKLIEPLRGLRMVHYMAWLAKRWQDPAFPIAFPWFNDAKYWENQILAFKEQIATLQEPPLSLQPQW
99
A8WRJ3
3.1.1.4
ACT_SITE 787; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 909; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"
MGSSNKDGPSCLPEVHKEPNLAISESTHSSDWYSATSSEDCWQGASQSFSGGKSNGKPITQKENSAAGEKMSCEMSDPKSCSFVPENNEKDSIHVGNFELKKGRSYSNPDLLVSMSPLAYRGEQGKQEMIASRQDLKEETTEIVAVVETVQTDDTTTTTAVITSTTMSGTASQDDFILVEAEQDEHIGLCDDTMPLVDKKDLSTTSATSSPARQITPRVESGLSFERVVSLVSVFPAMINKLLNKPWYPSRCDEVIQFPKEELHNYEIVPTEVDDEHFVIVTGIRSAEGRLPDSIYHLVFAYDGFFETDSTRPFSLFRATDKKDLMDLLHLCDEKSFLFTSLDTTRTDIRSKIEELVIQIRLKPHYHMIHVAIATDRLDFFSDDMIAAMNASMEPFASQLRCLCHTENCYPVHLALAMDRQKIVERLLELDPTLFCETDKAGNNVWHHASSSFCAQVSFFRIIWDKCPESKHFIDERNMDGQSPLNEAVSAAKPLVATFLISKGAKFTRGDRNELFVAMTSKNAQSVVEVVLMDKPELAHERDALGNSAIHVALYKESLNALLNKKVELGLDIDVTNNAGETALLLFITTRKPDLLPLLVTLYAHGANMNATDRHGNTALHKSAALVDARRISLECVKFLISAGADSNKVNLRGESPRHLAASLQNQEMLTILKAAGAKRCPKGYKGCRSNCRFNAASFDEEYEETIQNIHIGIETDYEKTELSAAERLNIEQNLENSGKCKKNKVNLISMDGGGIRGLVIIQTLIAIEERLGDDIFKYFDWSAGTSTGSLIMAGLATGKSLREMQQTYLLLKDKVFDGIMPPYDTVQLEKFIQDQFGTGTVWDIPFPRLMISAVNSEKLPVRLEMARNYKPAVDLAPETPREMPLWMALRRSTAAPVLFKPSEDRYIDGGIISNNPALDLMSEVHAYNRQLQLSGRKQEAVQMNVVVSFGTGQIPSTIIETLSIDSNSPLQSIKTIKNLAAMFIDQATASEGAPVARSRQWADSLEVPFFRFSAPLSKNIFLSSTSDLDVCTMMWDSFIYCRQHRGYIDELVRLLKFDDAHPYQKSPFAEL
130
A0A9J7MJF8
2.7.7.7
ACT_SITE 99; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MFGRFLVYSRRFGRFFHTSRTLQCSDDMSKRKGIAENVNSDFCDFLTELANYEKNVNRQMHKYNAYRKAASVLAKHPTRIKNGTEARKLDGIGEKIAKKIDEFVQTGTLQKLVKIRASDTNQAINLLTRVTGIGPAAARKLVDEGITTIEDLRKNPGKLNHHQQLGLKYFEDFEKRIPREEMLEMQSLIQGEINQLDSDYVATICGSFRRGAASSGDIDILLTHSTYSSEDKKKPELLKQVVHHLEKSKFVVDTISLGDTKFMGVCRLPAGKGSKERTFRRIDIRLLPNDQYYCGVLYFTGSDVFNKKMRAHALEQGFTLNEYTIRPLGSTGVPGEALPVSSEEDVFDIIGMKYLKPSQRSEGQ
121
Q10452
2.7.11.1
ACT_SITE 157; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNHGTKIPVDPFRIIKETARDGSTGEVKQLSYTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELRDPNTKLHNSRNPDASPRHLPELFNFSPFELSIRPDLNQKLIPSHARDALPVKLDDFVPIPIHRARID
99
A5I458
3.5.1.88
ACT_SITE 132; /evidence="ECO:0000256|HAMAP-Rule:MF_00163"
MALRQIRLFDDEILRKESKVVEIVDDKIRQILNDMADTMYNTENGGGLAAPQVGILKRLVVIDMGQGLIKLVNPKIIKQEGTQEVIEGCLSIPNKFGRVIRPAKVTVQALNEDGEEIILTGTGDLAKCFCHEIDHLEGILFTDLVTEYII
183
A0A3B5YRG0
3.2.1.52
ACT_SITE 337; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MPPKLLTRLILALVAVAVAVSGAAAARRHPAPANFTASGNPVYIWPLPKNFTSGTQTLAVDPDLALDPKGAGGGAAAVAEAFQRYRHLIFSPWAHAARPASAGYDVARLTVVVASADETLELGVDESYTIYIAAAGGANSIVGGATIEANTIYGAIRGLETFSQLCVFNYDTKNVEVRYAPWYIQDEPRFAFRGLMLDTSRHYLPVDVIKQVIDSMSFSKLNVLHWHIIDEQSFPLEIPSYPNLWKGSYSKSERYTVEDARYIVSYAKKRGIHVMAEIDVPGHAESWGNGYPKLWPSLSCTEPLDVSSNFTFEVITGILSDMRKIFPFGLFHLGGDEVYTGCWNLTPHVKQWLDERNMTTKDAYKYFVLKAQEIAIDLNWIPVNWEETFNSFGGSLNPRTVVHNWLGPGVCPKVVAKGLRCIMSNQGVWYLDHLDVPWEQVYTAEPLAGIDDAAQQKLVLGGEVCMWGETADTSDVQQTIWPRAAAAAERMWSQLEAISAQDLETTVLARLHYFRCLLNHRGIAAAPVTNFYARRPPIGPGSCFIQ
170
O67655
1.1.1.37
ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00487"
MRMKKTVAVIGAGNVGEHVASLILLKNLANVKMFDLPRKTEEKVFEPVKGKALDMKQMLAAMDIDARVEGYTVTPEGEGYEPLEGSDIVVITAGFPRRPGMSREDLLEANIRIISVIADRIKRYAPDAIVIVVTNPVDVMTYVAYKLLNFPKNRVMGMAGVLDSARFKTFISEELMVSPKDIHAYVIGGHGDEMVPLISISNVGGIPLKDLLPKEKLEKIIERTRFGGGEIVNLMGTSAYYAPAAAIVDMIEALVQNSKRILPCSVYLDGEAGEYYGVQGFCVGVPVKLGSNGVEEIIKVPMIEEEREMWRRSVESVKKTVEVAEGILSAGSSRQ
5
B4FYH1
1.11.1.7
ACT_SITE 109; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSKPAAALVMLLALVAAGPAAGDGGSTRLGCFVGWSPLKTVSSLLCLLQGSSTFPSPKPAPTGQGLSVGYYNKSGSCPKAEQLVREAVTSATNGANRGLNAGLIRLHFHDAFVRGCDASVLLDKTASNNTDTEKTGPPNKDSLRGFEVIDAAKAAVEKECPGIVSCADILAFAARDASYILSNEKIYYEVPAGRYDGRESFADETDQLPGPGSSVQDLKKSFAAQGLSLADAVTLSGAHSIGLARCLFFKDRLSAMDPGYAATLNATCNAGGDSYKVNQDYKSPDVLDNQYYKNIDKFVLFASDAALKSSETIDQVNANAGGYGKWEKDFGDAMVKMGKIGVITSPGYGAEIRKVCSQINY
14
Q7NLT1
5.3.1.1
ACT_SITE 94; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"
MRRKVLAGNWKMYKTRGEARAFLEAFVPLISPGAENREVILCGPFTCLDLLSAQAGPYAVGAQNVHWADHGAYTGEIAPQMLVELGVHYVIVGHSERREYFNETDSTVNRRLNNAQDHDLVPILCVGETESVRKDGITEAHIRSQLDRDLELVDMRRLIIAYEPIWAIGTGKTCEANEANRVCAMIRKHVNFEGVPILYGGSVKPENIDELMAQSDIDGVLVGGASLEAKSFARIVNFEV
213
Q9I3D5
1.3.5.1
ACT_SITE 289; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
MASIRTLSFDAIIVGGGGAGMRAALQLAQGGHKTAVVTKVFPTRSHTVSAQGGITCAIASADPNDDWRWHMYDTVKGSDYIGDQDAIEYMCSVGPEAVFELEHMGLPFSRTETGRIYQRPFGGQSKDFGKGGQAARTCAAADRTGHALLHTLYQANLKNGTSFLNEWYAVDLVKNQDGAVVGIIAICIETGETVYIRSKAVVLATGGAGRIYASTTNALINTGDGVGMALRAGVPVQDIEMWQFHPTGIAGAGVLVTEGCRGEGGYLINAHGERFMERYAPNAKDLAGRDVVARSMVKEVLAGNGVGPNKDHVLLKLDHLGEEVLHSRLPGICELSKTFAHVDPVVAPIPVIPTCHYMMGGVATNIHGQAITQDANGNDQIVEGLFAVGEVACVSVHGANRLGGNSLLDLVVFGRAAGLHLEKALKEGIDARGASESDLEASFKRLNGVNERTSGEEVAPLKRELQSCMQNYFGVFRTGEYMQKGIAQLADLRERIANVKINDKSQAFNTARIEALELQNLLEVAEATAIAAEHRKESRGAHAREDFEERDDENWLCHTLYFPGEKRVSKRSVNFAPKTVPAFEPKVRTY
28
Q6CGC9
2.3.2.26
ACT_SITE 838; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MFTNFTGDTRRARQVNLGGRGRQTANRESLLKKAADDRRKREEARKQDEAAKQIQLYWRKQVQEVRPKRLALKEKWLQSPDSVQEAIYFWRTLNMEEAKIVLQQCSELNAAPEQWSELGEEVCKWIISNGHKNASTILSTIAQYPVIIPSFFKAARVSEVTPEALNQQGRRNPAGFVLDYMTQEVNWQGIDLINVVLDTICKFARLPKNKAVGILSNMTQIGGDKFIPALSVVLSSVPFGDIPEELLERLEPLYSVNFVTQILDKYNYTDVSQVLVSLLRIHPERKQQVLQQLSLIDNPPVARVLWKSLFESGPIQKLYRDSMSANEVSEFLESSQYLHLTLLLELYSYWLIVTLDHEFRDQATTLLRFSEIENLMVVLKNLCVAMITNEIECNLIIAVLRQVYARDSRRPFLPKGFWLVRRLHVDTSFIKSLVEEEKMRLSQEHGVETTASRRMASRPSLSAMRSRNRTILSQLPFFIPFNTRVTLFEAFKAEDHSNVMGSEDVFLMHHTGRMGIDAPVIRGREFESAYEKLYSYGSELKKPLSIRFFNDFGPEAGIDGGGLTKEFLTSVTDDAFNTSRGLFAATDNHLLYPNPTTHDTKQLAFLGNLVGKGLYENILIEHGFASFFLQKWTQGSMRSSIDDLYSLDPNLYESLASLKQIYATQGDADLGLTFSIDYADSEGNVRTRDLIRNGSEVPVTKANYLRYIYEVANFKLNTSIRTQTDAFLGGLYQLIDPSWVSMFNADELQMLISGGHANVDVWDLKTHTNYGGYLDTDQTIKDFWTVFESFEEEDKRLLLKFVTSVSKAPLQGFKALNPSFAIRNAGRQVDRFPTASTCVNLLKLPDYQDIDQLRKKLLYAIRSHAGFDLS
65
Q8A9I3
3.1.3.3
ACT_SITE 201; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 203; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
MQPSNTELILIRVTGEDRPGLTASVTEILAKYDATILDIGQADIHNTLSLGILFRSEERHSGFIMKELLFKASSLGVTIRFEPIGTDQYENWVGMQGKNRYILTVLGRKLSARQISAATRVLAEQDLNIDAIKRLTGRIPLDEDKTDTRTRACIEFSVRGTPKDRIAMQERLMQLASEQEMDFSFQQDNMYRRMRRLICFDMDSTLIETEVIDELAIRAGVGDEVKAITESAMRGEIDFTESFTRRVALLKGLDESVMQEIAESLPITEGVDRLMYVLKKYGYKIAILSGGFTYFGQYLQKKYGIDYVYANELEIVDGKLTGRYLGDVVDGKRKAELLRLIAQVEKVDIAQTIAVGDGANDLPMLGIAGLGIAFHAKPKVVANAKQSINTIGLDGVLYFLGFKDSYLNM
147
Q59S66
2.7.11.1
ACT_SITE 365; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MMLPRNSPHRTESTLAYNNNNSNNNNNNNGSSLFQRKPLAPINSEFKISKPQHIKPTTHSHTFTTPTPKTRNTATTTTNNNNRNNHQYRNPNLNTSLVFTPTKNSSSSSSSHSSSLLSSSPFVEEPENQPESNHTRATSHYRTTSTSQYKSSANKDASHSLITSSKRKTSTKQTSESTNPKRRTTTTATQNTNNNKILNPSLSSSTIRFSTVSSSTSSSTTSSSSSSHTSPKPQQQLTLDDFEFGKILGKGKLGRVYCVKHKQSGLIFALKVMSKSEIMNLKLEKSLRREIEIQSNLYHINITRLYSWFHDSINIYLLLEYSIEGELYTHLKKLKRFDNIMASNYIFQITQALIFLHQRGIIHRDLKPENIMVSLDNQLKLSDFGWSVQINQNQNQNQIHNQTQTQKTPHQKKQKQKRLTICGTLDYLPPEMIESKSHDFSVDIWALGILCYELLVGKPPFEAINRNITYEKIAKVDIKYPSNLDVDAIDLISKLVVKDPNKRLSLKEVLNHNWIIKNKPKWPKNIYK
99
A0A9J7KWM7
2.7.7.7
ACT_SITE 341; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50"
MGDRKRGLPQDSQQPDTKRKKSLPTCGPKSAKATSSVDQNVPKIFQDVRAFILPAGLGKARMDIFKRQIPRFGGDLHGQISSTTSHIVVDDNMEYDRLCRILKVEKPPVHASVVHANWVSDCIESRTLLGTDEYTIKVPASVTLIPQKKTTSEDEKESVSKSEGRSQATGQSDLPVQKVDDEGDQKDSGVESAATSQPSPAKDAWWWRKNKTKVPTGEDSDDSSYIPTDEDEDEEDAGNQLQEVESSPSTSASSTPNTSPQKLPRGKWVCAEPSTSKGVNYNKHITDKFQLLAKAYKNTSDQWRALSYTKAIAILQRHPKPITSWEEAHSLPGVGQRLADKIWEVVESGHLRKLDHLGPEHEALNLFNDVWGAGAKTAQQWLQQGLRTLDDLRTKAKLTRQQQIGLKHYDDFLDRMPREEAAEIERTVREMAESINPGLMAMACGSYRRGKLNCGDVDVLITHPDGKSHKGIFQKVLNGLKETGFLTDDLVTQEDNGEQKKYLGVCRLPGEGRKHRRLDIIVIPYSEFACALMYFTGSAHFNRSMRALAIKKGMSLSEHSLNTGVIRKGKEKIFGGTPLPCQTEEDVFRHLGLDYRPPHERDW
121
A0A8I3NRW3
2.1.1.33
ACT_SITE 303; /evidence="ECO:0000256|HAMAP-Rule:MF_03055"
MRSRPSRSRPPSDRAGRARGTGETSEGLAIGSGPRGPLTCGVHRCLRLGQQRRPRGSAPTEAARCPVGPWQPTGDPRRGGALPPRPRPRPRPAGRTHSWVFKRRGPPPTCRGASSSCASGLGLHVGSEENPGLGIMAGAETGGAAGDGAGAEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNKTHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFRKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLGVGGLVYTITDVLELHDWMCTHFERHPLFERVPLEELSEDPIVEHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPTLQKAEEAT
45
P36582
2.7.11.13
ACT_SITE 789; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MVQLDDALQDAYKKVEREESLILGAKAMVASTKNPEVKRRLESNIAVSENNIKYLRERIDALKVESGSERESQSDKDSSKKYSDSAKSTNSDDHLLSYNRSAFDLFNSEKPLSPEKISTMLQHLQMRLSIEQQCVSGIEKIMSLYSKEQKDKTDVIIKLKEGKQKVNLLKRSLKRYNELHIPFDISTPSSEEKQQASGLNFRGLAKPISGTLKVTIHSLRNIEHTSFLQTHSFTMPSYAVLYVDDAQVAKSRISQTDTWDETFIFDVHRAKEFQIIIYEKKKDFDIPIALILIPTTIIAEELRRKRNIQEMSETSWKPSIAESASRSDEKGSKSDPINAPNSSSSISTNSPLAPTAYYKLLSKSWLSLEPVGQICISLSFSKRTTKRQFPETGLGRQGAIRQKKEDVVASQVGHQFVQRQFYQIMRCAVCAELFSYSPGLQCENCSFVCHKKCVTKVLASCIAQSNSEKSDFGGLRYRIPHRFEPFNSLGAQWCAHCGFFLPLRRKDCFKCVECGITCHGQCAHLIPDYCGMSNDLKHQLLTELEVSKRPKKPELPNQENKTTNEKVYRKPLSSQNTFDTLPTISQGLLAATQPVTSVLNTSPLPKTPEKDRSLNVTPSSSTPTPASVLAPPSSASLSSSKDANRSVPESPRREKKNRVTLDDFTFLAVLGKGNFGKVMLAEYKVNKKFYAIKVLKKEAILKNEELESLKTEKHVFEVANKEKHPFLLNLFASFQTSTRVYFVMEYILGGDLMVHIQRQQFSVKRARFYGAEVCLALKYFHENGIAYRDLKLDNILLCPDGHIRIADYGLCKENMLLGNTTSTFCGTPEFMAPEILLEQQYSKDVDWWAFGVLMYQMLLGQSPFKGEDEEEIFDAILSDEPLFPINMPADAVSLLRGLLTRDPNQRLGSGPKDANEVMAHPFFASIVWDDLYNKLYEPSYKPLINDPRDLNNFDEEFTSACPTLTPVNTVLTRQQQECFRGFSSFATE
100
Q9K3T8
3.1.1.29
ACT_SITE 28; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083"
MDVTTDAGAPWLVAGLGNPGPEYASNRHNVGFMVADLLAERIGARFKRHGKAQAQVVEGRIGPPGPANRRVILAKPMSFMNVSGGPVTALRDFYKVPVGNIVAVHDELDIDYGVLRLKLGGGDNGHNGLKSITKSLGADYHRVRFGIGRPPGRMPVADFVLRDFSSTERKELDYFVDRAADAVEALVIEGLERAQSAYNS
127
A7ST16
2.7.11.23
ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR637770-1"
MAAKVERSKRYKKIDFLGEGQFATVFKAEDQETGNIVAVKKIKLGNRAEAKDGINRTALREIKLLQELSHENVIGLLDVFGHKSSISLVFPFMETDLEVLIKDTCIVLSPADVKSFTIMTLKGLEYLHSHWILHRDMKPNNLLLDDKGVLKIGDFGLARAFGSPSRVYTHQVVTRWYRPPELLFGARIYGTGVDMWAEGCILAELLLRVPFLPGATDLDQLSRTFQTLGTPTEETWPGMTSLPDYVEFKPFPGIPLKDIFSAAGDDMLDLLDRLLDCNPNGRVNATQALNMPYFSNKPAPTPPHLLPRPKSSGKVTKKEEEKSLKRKLESATDGAIG
103
A0A072VKX1
1.11.1.7
ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MANKPRSNSSFLFLLLILHFNMGKSQLQLNYYSTSCPRAEEIIKQQVTELYNQGSTAISWLRNLFHDCMVNSCDASFLLATWRGVVSEQTSVRSFGMRNFKYVNTIKAAVEKECPLTVSCADIVALSARDGIAMLGIPNIEMKSGRRDSKESYVTVVEESIPSHNASMSLVLTRFQAIGVDVEATVALLGAHSVGRVHCINMVHRLYPIVDPTLDPTYVVYLKRRCPKPNPKAKAVQYVRNDLKTPLIIDNNYYKNILQHKGLLTVDEELATDPITSPYVQKMADDNGYFNDQFSRAVLLLSENNPLIGDQGEIRKDCRFVNAN
14
Q81J01
2.6.1.16
ACT_SITE 2; /note="Nucleophile; for GATase activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"; ACT_SITE 595; /note="For Fru-6P isomerization activity"; /evidence="ECO:0000255|HAMAP-Rule:MF_00164"
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVAASVGIGHTRWATHGVPSKVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGLLDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDASDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELNQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPVEVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTKAYTAQLAVLSILAADIAKAKGEVLDFDLTHELGLVANAMIELCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGALKLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPTVHEALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
81
A0A1D8PMZ8
4.1.1.50
ACT_SITE 81; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 95; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 289; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 302; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"
MVAPALIYSNHELSTAIDSTHAFEGPEKLLEIWFYESKELSPINLRDIKFDTWIEILNLVHCEVLSKVSSNLCDAFLLSESSLFVFPHKIILKTCGTTTTLACLDLLFETVNKELLQNEGLKATFQSKNIYQIFYSRRSFMFPDRQIHVHGNWQEEVKLLNQYFNNGKSYIVGNNTNWHLYVGGNGKTKNPVASTTTTTTPVVNDCTLEIIMTQLSLEASQQFYTTRKPGDTAIDSNHDLGHDLGQEILKQTGLNELFKFKKQPTMPGLSSSPIKEIHDGFAFTPCGFSSNSINESDYYTIHVTPEPGWSYASFETNMIGDYKAIVDKCINVFQPGQFMVTFLTNTDMEKFECCLDDYKVNHREELDVEDYKLYFVEFVRQ
196
A0A2R6X6V1
3.4.19.9
ACT_SITE 155; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 267; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 267; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MERSSVSPCRVLLLVLVSQIFLHDTVFGGRIRMPSERLGFDDGSVVRATQPLIGILTGEMDDMIGGFGTYHPGMSYIAASYVKFVESGGARAVPLLHNEPVESLRRKFSVINGLLLPGGDTNMDGGPFLDTVKLLLDWAIEANDKGDYFPVHGTCLGMEVLANVIAQRNMMESCIAKKTPATLQFIDESKKSKSFFKWVPEDVLEKIPTVPLTIMNHKMGITPATFASTKPLADFFEVLTLSPDDYGQMYVSSVQGKKYPVTATMFHPEKNMFEWTYNTIPHSAAAIQLSQSIADYFISEARKSSHAPSSQDEVNNLLVNNYQPVFLGKIPPPIPFEEVYYFG
176
Q5KEK1
2.3.1.48
ACT_SITE 514; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MQTPAHHGHRLHGHGAVIREDFCSFCGGTDAINKQGVQETMVSCAACGRSGHPTCLNMLTPKLRKRVMMYDWHCIECKTCEQCAIKGDDSRLMFCDTCDRGWHSYCLNPPLAKPPKGSWHCPKCLSPPAVSSGSISNPRSATRPSKLHPRPSKPGKARPANTPNTSNNRRRPKQSLAGDDALFTSHRIKVKVPNPNYQYRDSEEGRGTPMIVRLKVPKRPVEEEPEEKKIPYGGVITGDDADTTRTKITEADKEAYQMAKNAAEKQLGGPVPTRETPGPGSPLPMASPSGKTTPSSKFPATSRPLRDRLLHQTLPDAYPFPSTPGTTQEVVPWTGSARLEKIKTIRFGPYDINTWYSAPYPEEYAYVPDGRLWLCEFCLKYMKSGFAATRHRLKCKSRHPPGDEIYREGAVSVFEVDGRKNKIYCQNLCLLAKMFLDHKTLYYDVEPFLFYVMTEVDELGARFVGYFSKEKRSMDNNVSCIMTLPVRQRKGWGQLLIDFSYLLSKKEGRTGSPEKPLSGLGAVSYKSYWRLTVFKYLLNAISPSFNHTLELPPVPDATPGPTSELDFNSNTETKPTPPRITSKDISKATSMTLEDIFTTLSAEGMINVLDDLTVDAIGKTPNSARTRGRSRGRPNVNRRKADLNGSGTLDPQIHQDEDDHVKLPKRYEILLDKAYLQAVVEKHEKKGYLKLAPERLKYHPFLVARQTEEPESGGKKEDENEENGNEKDKEREDESENGVVRFVDSIAEAAHIIAQSHAHFHTVPSSTISRTSHHPVYPTPTPNHNSIPNRNTTSPARNLRKRKSDVVLETPVRKLRSRDNIREGMGTSPRTLRMRNAVALGEGIAEGEEENQGLSKLNQLPVKPVTQFADGEIPIDPALLEESVTLDPSMYGSVGEEVYDNDAEGEEYIGEDDDAEGEEYIGEEEDAEGEADEEYIDYDV
61
W5N0P5
2.7.10.1
ACT_SITE 841; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
MQFEIAIVLSSLLTLGCCSIQDKRVCQGLSNKLTLLGTSQDHYNNIVRMYSNCTVVMENLEITYVEKDYDLSFLKSIREVGGYVLIALNKVSRIPIDNLRIIRGHILYQNSYALAVLSNFDKQSSVNKNQSSNVGLQELSLKSLTEILKGGVKFTGNPFLCNAETIQWYDIVDKSKNPEMFLIFANNTLNCKKCDPNCFNGSCWAPGPSNCQTLTKLNCAEQCSHRCKGPKPSDCCNEHCAAGCTGPRSTDCLACRDFQDEGTCKQVCPQLMLYNPNTHQLEMNPDGKYSFGATCVKSCPHNYVVTDHGSCVRTCTANTHEVDENGVRKCKKCEGPCPKACNGLGMGNLVNVLSINASNIDSFRNCTKINGDVSILPVAFRGDSYTKTPVLDPSKLDVFKTVKEITGFLLIQAWPENMTSLSPLENLEIIRGRTKQHGTVSVAAVNIDITSLGLRSLKEISDGDVVIRGNPHLCYTNADQWKRLFKLEKQNARVSENADPTECSALTQTCDELCTSEGCWGPGPSMCFSCQHFMRQQQCVNACNVLEGLPREFIMDKKCIECDPECMPQNGTQTCTGSGPDKCAECAHFKDGPHCVHKCPSGIPGENDTFIWKYADEKKVCQLCHPNCTQGCTGPGLAGCDHQTSQLSSIAAGVVGGLLVTVIIALAIFILMRRRYIKRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIQVLGSGAFGTVYKGLWIPEGEDVKIPVAIKVLREATSPKANKEILDEAYVMASVNNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVKEHKDNIGSQYLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADEKEYHADGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEIAGILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPRFRELIAEFSKMARDPPRYLVIQGDERMHLPSPTDSKFYRTLIDGDEMDDVVDADEYLVPYNGFFNSPSTSRMQLLHSMSLNSSMGSCTIRNGQGYPMREDSFIQRYITDPTDGAFEKDFQPVPEYVNQNGNPVSDVMNPIYQDSVVPISAVTRAQNADSQYLNSFSNTADFHEYLNTVQPALPRPLFDNPHYCDQKVTHQTSLDNPDYQQDFFPPKSKVNGHLPAAENTEYLALSAQAEKYIYSTP
97
A8ICG9
1.1.1.37
ACT_SITE 198; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
MADPLNRIQKIASHLDPAKPRKFKVALLGAAGGIGQPLSLLLKMSPYVSDLALYDVANTPGVAADVSHMSTAARVRGYLGPDQLGAALTGAALVIIPAGVPRKPGMTRDDLFNINAGIVRGLAQGIAQHCPAAWVAIISNPVNSTVPIAAEVLQKAGVFNPAKLFGVTTLDVVRAEAFIGELTGTDPRDVHVPVVGGHAGVTILPLLSQARPPLPASMSAEARKALMVRIQDAGTEVVQAKAGAGSATLSMAYAAARFADSCLRAMSGEGPVSEYAYIRHPPRLSSGSGSSVAVDLPYFSSPVRLGRLGVEEVLPLGPMDALEADNFAAMKAELLGSIKKGVEFAAKGPAPAK
5
O59868
7.2.2.10
ACT_SITE 329; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250"
MSVQYDAFSVEQTCADLETDMYNGLSSLQEITRRNKVHGDNDLKVEDEENMVVQFLKQFVKDPLILLLFASSAISVTLGNIDDAISIALAIVIVVTVGFVQEYRSEQSLKALNNLVPHYCNVIRSGKTEHIVASKLVPGDLVILQIGDRVPADLRIVEATELEIDESNLTGENSPRKKSSEAISSNISLTERNNIAFMGTLVRHGHGRGIVVATGSDTEFGRVFLTMQQTEKPKTPLQNSMDDLGKQLSLISLIGIAVIVLVGFFQGKNWLEMLTIGVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIIRRLPSVETLGSVNVICSDKTGTLTMNHMTVTKIYTCGMLAAFSLPESEHIELSVRRTVGIEKALLAAALCNNSKVHNKADSILDTTCPWAGFPVDVALIECSERFGLKDPRETYSRISEVSFSSERKYMSVAVQYNSSKMNFMKGATEQVLSSCAYFSDQDGVQHELTAEMKENIQRNEFEMAASGLRIIAVASGINTNKLVFHGLFGINDPPRPQVRESVQYLMTGGVRVIMITGDSVVTAISIARSLGMAIPSNDEEAIRNYALTGAQLDDLDSSSLRDAVSRVVVFARTTPQHKMKIVEALQSLGDVVAMTGDGVNDAPALKLADIGIAMGRQGTDVAKEAADMILTDDSFATILSAVEEGKGIFNNIKNFITFQLSTSVAALSLIAISSVFGFQNPLNAMQILWINILMDGPPAQSLGVESVDEDVMMKPPRPRNAPIISVQLLQRVLLSAFIIVTVTIVVFRVQMQDGNVTARDTTMTFTCFVFFDMFNALACRSETKSVFKLGIFSNRMFNIAVGGSLIGQALVVYASPFQRIFQTEAIGLKDVLILLACTSSVLWVDEIRKWYRRRKGLVRTKSNYLLRNV
258
E9FWC0
2.1.1.33
ACT_SITE 137; /evidence="ECO:0000256|HAMAP-Rule:MF_03055"
MASLPQKKYYRQRAHSNPIADHCFDYPVSPNDMKWDELYPTFSKDGIMKHKVQFADIGCGYGGLLISLSTVFPETLMLGMEIRLKVSEYVQDRIKALRILHPGDYGNVACLRSNAMKYLPCFFDKGQLTKMFFLFPDPHFKKAKHKWRIINDTLLAEYAYVLAEGGLVYTITDVKDLHEWMVMHLDQHPLFKRLTQEELDQDIVVPKLYESTEEGKKVTRNSGDKFLAVFRRIPDPFVLEENKC
45
A0A7M7PKH2
3.1.1.4
ACT_SITE 80; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 134; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"
MDLIMNSFLTLIIINVCLLFGIGQADLVHRRRPRAIWQFSSMIECATGRPALHYNNYGCWCGLGGGGEPVDEVDKCCRSHDECYDYLTEEGTCSILSLYLTSYLYERRHCQEMEEPSISCGEGSPCRTGLCDCDREAALCLAHAKYNDHRHNYDKDLCIP
130
A0A1D6EBX4
3.2.1.1
ACT_SITE 193; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 218; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MGQMISGDKSDEQTARDDGIIKNGREILFQAFNWESNKHNWWSILEEKVTDLAESGFTSVWLPPPTQSLSREGYLPQNLYCLDSCYGSLHELKLLLHKMSEHNVRAMADVVINHRIGTTQGSNGMYNRYDGIPVSWDEHAVTSCSGGKGNKSTGDNFDGVPNIDHTQPFVRKDIIEWLIWLRKSVGFQDFRFDFTKGYAAKFVKEYIEESKPLFAVGEYWDSCEYSPPDYRLNYNQDVLVSFCLPDIHRQRIINWIDNTGGLCAAFDFTTKGILQEAVKGELWRLRDSEGKPPGVMGWWPSRSVTFIENHDTGSTQGHWPFPSDHIMEGYAYILTHPGIPTVFYDHFYDQGVPLHDEIAKLMQIRKCQDIHSRSSIKILEVGSDLYSAIIDDKLCMKIGDGSWCPSDPEWRLAVSGDRYAVWHK
157
A0A1S3Y577
3.5.1.2
ACT_SITE 149; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 254; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 256; /note="For GATase activity"; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 297; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"; ACT_SITE 455; /evidence="ECO:0000256|PIRSR:PIRSR036936-1"
MEAASFTSTSQFLTAKSSSSSSSSTTSYPSFSSTSQSLYSLRYKPHAKALNCKSSRSFSVRASAGGADDSVVTLLDYGAGNVRSLRNAIKYLGFDIKDVQTPEDILKAKRLIFPGVGAFAPAMDVLNKKGMAEALCTYIEQDRPFLGICLGLQLLFESSEENGPVKGLGLIPGVVGRFDSSKGIRVPHIGWNALDIAKDTQILDDIGKSHVYFVHSYRATPSDDNREWISSTCKYGDNFIASIQRGNVHAVQFHPEKSGDVGLSVLRRFLNPKSGRTQKLVQGNASKLAKRVIACLDVRTNDKGDLVVTKGDQYDVREHTKENEVRNLGKPVDLAGQYYKDGADEVSFLNITAFRDFPLGDLPMLQVLRYASENVFVPLTVGGGIRDFKDGNGRYYSSLEVASEYFRSGADKVSIGSDAVYAAEEYLKSGVKTGKSSLEQISRVYGNQAVVVSIDPRRVYVRDPKAVEFRTIKVRNPGPNGEEYAWYQCTVSGGREGRPIGAYELAKAVEELGAGEILLNCIDCDGQGKGFDIDLIKLISDAVSIPVIASSGAGTVEHFSEVFKETNASAALAAGIFHRKEVPIQSVKEHLVKEGIEVRM
181
A0A9J7MHV0
4.1.1.17
ACT_SITE 373; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MKTHIMNKDLSMEVLRDGLTARDVLTNKVNSGGRDDKDDAFFVCDLGDVVNKYKKWVSCLPRVEPFYAVKCNDSPHVLQVLANLGTGFDCASKTEVQTVLNLGVAPDRIVYANPCKQTSHIRYAKKNSVDLMTFDNEDELHKIKNYFPDARLLLRILPPAAEAQCQLGMKFGCHPSQAPKLLEVAAQLDLSVVGVSFHVGSGCLEASAFARGVESAKRIFNIADQYGFDFDMLDIGGGFPGQESAAISFDEIVADLGPALDEHFPPASGVRIIAEPGRYFVASAFTVAVNIVAKRMVARDIQEFKDEEAEDAVMNSVAPSMCEEPAFMYYVNDGVYGSFNCLLYDHAAVTPSLMRDVDKEEALFSTSVWGPTCDGLDRIMEHCLLPELQVGDWILFEDMGAYTMAAASTFNGFSKPSCYYVVDANMWSSNNHAFIQSECYTRRQVKDSSITLPAIKRGLCAQERLGITQIPSVAVPEV
195
G7P9I7
2.7.10.1
ACT_SITE 1111; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1"
MKSGSGEGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKPTIDEEVGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTVADTYNITDLEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKDEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
97
Q7NCJ1
1.3.5.1
ACT_SITE 277; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
MLEYDIVIVGGGLAGSRAAVEIARTDNRLKVALVSKVHPIRSHSVAAQGGIAAALQNVDPQDNWLTHAFDTVKGADYLADQDAVAVLTQQAPQVIIDLEHMGVLFSRLPDGRIAQRPFGGHTHQRTCYAADKTGHAILHELVSRLFQYKVPIFEEWYVLELIVEEGEARGLVMFHIPTGRIEVVRAKAILFATGGYGRVFNTTSNDYASTGDGLCLAAMAGLPLQDMEFVQFHPTGLYPVGVLISEAVRGEGAHLINDAGERFMAGYAPSRMELAPRDITSRAIATEIREGRGVGGGRYVHLDLRHMGKEKILERVPFAHDEALRHLGIDVVYEPMPVRPTVHYSMGGIPTTVDCQALAAHGQVMEGFFAAGECSCVSVHGANRLGSNSLLECVVYGARAGASLARYVQDRRLPHVDEARHRRVAEQGIQNLLDQPGSLRIDALRREFQDTLTDHCSIFRDEQILKTGLEKIQQLKARYGDIRLDDKGKLYNTEITEAFELRSLITVGEIIVASALERRESRGAHSRSDYPERNDGEYLKHTLAYREGDALRIDYRPVDLSLQAVDPERFTPQARKY
28
A2DXX8
2.2.1.1
ACT_SITE 407; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1"
MEIDELCVKTLRCLVSDMIHNARSGHPGSALGLAPALHILFSKFINFDKKWINRDRFLLGPGHASTILYAILHLYTGNLKMEDLKQFRRYGSLTPGSPEASITEDIEVTTGPLGLSVGYAAGMGCAEAHLEARFNRPNFPIFNHKVFAVISDGEMMEGPQAESASWIGHQRLDNLVCIYDSNNITINGTTDIAFTEDVMKRYEAYGWKVLEVKNGNTDLKEIENAIKQAIEIKGYPVLIKLNTTIGYGSDDANTTKIHGTPFNDEEIKKLKQNLGADPNATFFVPQEVYDYYKQIRERTQQKVEQWNKMFAEYKNQYPKEYEELQKIINPHYTIEEFKKFMPTSNINDVIATRVSSGRILNILKDHLPGLIGGSGDLTPSVCTALKGEKDFQKGCREGRMIEYGIREHAMQCIASGISYYRLPGLIPFTATFLVFYQYAFGAMRVAAIDRLKQIHILTHDSIGLGQDGATHQNIENFAMLRSLPHITLFRPCDYLETSACYSLGLAERKGPIMLALSRQNAPPVPGSSFDGALHGAYIIKDSPNPKLIFVATGTEVYLALKTSELLDVETRIVSMPSTQVFEEQPDEYKRKVLPGNVPTISIEAGVRLGWERYSHFHFGVDSFGCSASGEKMYELFNLTPEKCAERAKKVLDYFKDKPIPDLSPRPTF
51
A0A022RNH5
1.11.1.7
ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MATLNHTFIVLLLPLLLQFYSVKSELQLNYYSKSCPRAEEIIKEQVAILYRKHGNTAVSWIRNLFHDCVVKSCDASLLLDTVVGVTSEKTAARSFGMRNFKYIDTIKDALEKECPLTVSCADIIALTARDGAALLKGPEIKMKTGRKDSKESYAAVVDKLIPNHNDSMSLVLSTFQSIGIDTEGTVALLGAHSVGRVHCRNIVQRIYPTVDPSLDPQYADYLKFRCPSPNPDPKVVDYVRNDLETPMELDNMYYKNLLSHKGLLLIDSELVSNPTTYPFVVKMAADNAYFHDQFSRALLILSENNPLSGDQGDIRKDCRFLNH
14
Q2NS86
2.2.1.2
ACT_SITE 131; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492"
MNQLEGLKQFTTVVADSGDIESIRHYTPQDATTNPSLILKAASLTAYQPLFEDTLAYARKQGGTRETQIINASDKLAVNIGVEILKSVPGRVSTEVDARLSFDRGMCVAKARKLVALYQEQGIDKSRILIKLASTWEGIKAAEELEKEGINCNLTLLFSFAQARACAEAGVYLISPFVGRIYDWYNQRKPLDPYVADEDPGVVSVRKIYDYCKQHRYQTVIMGASFRKVEQILALAGCDRLTISTTLLEELHKADTRVERKLSPSTEGFHQPAPLSEPEFRWEHNQDAMAVDKLAEGIRQFAVDQQSLEDLLAAKL
52
B8BQI4
5.1.3.15
ACT_SITE 155; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 253; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
SADAETASSAGLMTNDDGLEYVRLSNAAGDTSDIYLYGGVVTSYVKGGQEYIAVRPDAKMDGSKPISGGLSHCWPQFGPGEIQQHGFARNVNWTVKSMDDTSCVLEMAPSDYTKEMWDKEFLCTFSVNLEDDQLSTKMFVENKGEESFDFQAALHSYFTVSALENLSIAGSFAGKEFLNKMVGDGEMQTEERDVITISEEYDRVYTGVNDPVLQDKGTGKSLSVLNTAGYEDTVLWNPYGNEGMGYNNFVCVESVKFDPVTLAGGASWTGDMALKVGDL
210
A0A2C9U9W0
3.1.1.11
ACT_SITE 369; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MGLLHLIVFWLLGSALEATVSCGAVNFQARIQSECSFTRFPSLCRNTLMELRDHSTVHVVSALVNKTISETRLPSSYFQTLSSQLETHDAHLAKSVTGYCENLMKMSLKQLDKSLLALKESPKKNKNDIQTWLSAALTFQQACKDSADSLGLPAGEVNSQISSKMDYLSQLVSNPLALVNRITSNSVKLKNNTRTRHLGEEVEDFPKWVSARDRKLLQSGTIKANAVVAKDGTGNYKTISEAIEAASGGRFVIYVKSGVYKEKIRTNKDGITLIGDGKYSTIITGDDSVTGGSSMPASATFTITGDGFIARDIGFHNTAGPQGQQALALHIASDHSVLYRCSIAGYQDTLYALALRQFYRECDIYGTIDFIFGNAAAVFQNCYLVLRRPKGGAYNVILANGRTDPGQNTGFSIQNCRITASSDFSPVKHNFNSYLGRPWQPYSRSVIMESNIDDAISSRGWIEWPDAKSYGKTLYFAEYLNTGPGAGTSNRVTWPGFHVVGAQEAVKFTVGNFIDGASWLPSTGVTFVSGLQ
125
B8CAQ2
3.4.19.12
ACT_SITE 108; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 183; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"
MSDGNNDWCTIESDPGVFTSLIESFGVKNVELSELWSLDDESLLSLTNPMEGVENASVHGLIFLFKWQSSHAGNTNDNSPEEETGKALVGEDVPNDLFFAKQVTHNACATQAILSVLRLVLGSTLSNFKSFTSHFPPDLRGEAIGSSDEIRTAHNSFGRAEDAFLSDPSKPKRIATDDDDVFHFVAYVPNDKDECVYELDGLKEGPIRVGSYKKEGEDGNSTLQWVQVARDSIQNRLSHYSPTEIKFNLMAMVQDRRTYLTERLNSLAAIGIEESDPAMLTVRSELHLEEEKRARWEIENERRRFNYLPFCVELLRSLAGSGKFESLVDKAKTSAGEKRKRAEAWKKQG
175
O13839
2.7.11.1
ACT_SITE 151; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MEKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNIVQYCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENAPACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVFTQSYVGTPYYMSPEIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDIRSKLESERVVLEQSDLLHKKHQMLIQLENDLQFREQRLSARESELENVIASRLAQREEILRRELEKQLRDMDARYQRHMQTVVNSMQKMRVTSPVDHNEQPESSTAEMFVDCTIEASQSPLLHIPKLGISKPLQTLSCPGFTLTTQQPILKRPTLRKELSSRALHTTATLMKYRANASSLRTTPIDKDGQITSLQQKNGTSNQVADCMNKLLHTSLDGKKLSPSELCNKFSDGEGLPNRKVSKLSVESDETAVSASSGESVPTDSTLTDTKSKSVFVHPPSPQSLYVEKLEKLNIRSDEVSKPSKASKTLHGYALPSLASPYDVHAEEKIARENEMDGNFKTMKINQHPDEYVLRTPKKIQLLEGQKRSPVKQLGRLGYNKLRRSAMDNAGLELRKAASTSNYTSLQSRTLPGSWRDDEEEIPRPFLRKMLDARMMRA
99
Q93IN2
2.4.1.12
ACT_SITE 313; /evidence="ECO:0000255"; ACT_SITE 457; /evidence="ECO:0000255"
MSALSRWLLIPPVSARLSERYQGYRRHGASPFSAALGCLWTILAWIVFPLEHPRWQRIRDGHKALYPHINAARPRPLDPARYLIQTLWLVMISSTKERHEPRWRSFARLKDVRGRYHQWMDTLPERVRQKTTHLEKEKELGHLSNGARRFILGVIVTFSLILALICITQPFNPLSQFIFLLLLWGVALLVRRMPGRFSALMLIVLSLTVSCRYIWWRYTSTLNWDDPVSLVCGLILLFAETYAWIVLVLGYFQVVWPLNRQPVPLPKEMSQWPTVDIFVPTYNEDLNVVKNTIYASLGIDWPKDKLNIWILDDGGRESFRHFARHVGVHYIARTTHEHAKAGNINNALKHAKGEFVAIFDCDHVPTRSFLQMTMGWFLKEKQLAMMQTPHHFFSPDPFERNLGRFRKTPNEGTLFYGLVQDGNDMWDATFFCGSCAVIRRKPLDEIGGIAVETVTEDAHTSLRLHRRGYTSAYMRIPQAAGLATESLSAHIGQRIRWARGMVQIFRLDNPLFGKGLKLAQRLCYLNAMFHFLSGIPRLIFLTAPLAFLLLHAYIIYAPALMIALFVIPHMVHASLTNSKIQGKYRHSFWSEIYETVLAWYIAPPTLVALINPHKGKFNVTAKGGLVEEKYVDWVISRPYIFLVLLNLLGVAAGVWRYYYGPENETLTVIVSLVWVFYNLVILGGAVAVSVESKQVRRAHRVEIAMPGAIAREDGHLFSCTVHDFSDGGLGIKINGQAQVLEGQKVNLLLKRGQQEYVFPTQVVRVTGNEVGLQLMPLTTKQHIDFVQCTFARADTWALWQDSFPEDKPLESLLDILKLGFRGYRHLAEFAPPSVKVIFRSLTALIAWIVSFIPRRPERQAAIQPSDRVMAQAQQ
70
I1HSD2
1.11.1.7
ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MALDVVLVRLLIIAAVASVLPARGRADGAAGLAIGFYNEKCPGAEDLVLEEMRDIVHEDRTLGPALLRLLFHDCFVRGCDASIMLKSRSKKGERDAKPMSYSLRGFDEVERIKAKLEEACPLTVSCADIIIMAARDAVYLNNGPRFPVETGRRDGKVSNCVDAENDLAPPNANIVDLKTYFSVKNLSWKDLVVLSGSHTIGSSQCAAFAGDRLYNHSGKGMQDPTLNKTYAPDLRMMCEAGNETDTTPVSMDPGSPHEFDLSYYRDVYSNKGLFVSDQALLDDKLTHDYVARMAAAPSPDEFFDDYAAAMINMGRMEVLTGHNGEIRKICGAYVD
14
A0A9R0KC77
3.4.19.12
ACT_SITE 20; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 122; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 137; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"
MEGPSNGGMLYHEVQEAKLCAVHCVNTVLQGPFFSEFDLAALASDLDRTERQMMTQNSVGAGDFGSAESHNVSLGGDFSIQVLQKALEVWDLQVIPLDSPVAEPAQVDPELENAFICHLQDHWFSIRKVNGEWYNFDSLYAAPEHLSKFYLSAYLDSLKGAGWSIFLVRGNFPKECPLSSEASNGFGQWLTAEDCVRILKACNSKGESSRAVDPVRREPSDQFPSLSDAQLLAMEDEDLKAAIAASLMDSTPSIPNSDSSDPSTEKSS
175
F4PCH9
2.7.11.1
ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1"
MATSYTVHGRPPVQVQIKSQSSVNTKLQQHLAAVGSLERQLKAIEVTDKENTIPTSDKHKSESSKPDTLKLHPQLAATVDQERTRQKPGVPDPDQRKWSLSDFDVGRPLGKGKFGRVYLAREKHSGYVVALKILFKSELSEAKVEKQLRREIEIQSHLRHPNILRLYGYFYDSKRVYLILEFAAQGEMYKQLRKLTRFPEPQAAKYISQMANALAYLHRKHVIHRDIKPENLLLGLKGELKIADFGWSVHAPNARRQTLCGTLDYLPPEMVEGKDHNEKVDLWSLGVLCYEFLVGVPPFEDQRSYKETYRRIAKVDLHVPDYISPEAKDLIVKLLQRDPNNRMPLESVIQHPWIVKHITTVVESK
99
K3XJ87
1.11.1.7
ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MARAGTSRAAAAVALVVAVLCASAAAEAGITRPPPVARGLSFNFYKKTCPNAEALVRGFVHDAIQRDVGLAAGLLRLHFHDCFVQGCDASLLLDDEHGEQKALPNLTLRREAITAINDIRDRLDKACGGPVVSCADILTLAARDAVVERGGPRYKVPLGRRDNVNFASHDEVNKGLPSPDANVGAMLEVLRKGNLGLDATDLVALSGAHTIGLSHCTSFENRLFPRQDSTMDAAFAAQLKQTCPAKGVSRTTPLDVRTSDVFDKMYFVNLVNRQGLLTSDQDLFTEARTRPAVQRFARSQNAFFRQFRVSMVKMGQIKVLTGDQGQVRRNCSATNNLMRTTSTAAGLPWWFVVPEAETSLVF
14
A0A1L8F4K7
2.7.10.1
ACT_SITE 1141; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000620-1"
MDRQGFLLVTSLKGLLLILLVFHANGDSTHLCGSMNIRNDVSQFRKLENCTVIQGNLQILLMFGTKPEDFRGLRFERLTMITEYLLLFRVYGLESLRDLFPNLSIIRGTDLFFHYSLVIFEMPHLRDIGLHSLTNILKGDVRIERNQELCHISTIDWSLLSESVENNYIVGNKPVEECADVCPGIRDFGESCVKTHINGHVESRCWTSTSCQKVCNCGKDIACSNTGECCDPECLGGCNKAGDPRACVACRNFYIDDQCLPSCPPGTYEYEGWRCIKEAYCGNLRKESESSQESTKFVIFENRCLSECPPGYTRNDSSIFCHKCEGLCPKTCKSGNKVIDSLEAARELTRCTCIEGNLILNIRRGYNLASELQKSLGLIETITGFLKIKHSFALVSLSFFKSLKLIRGDTMVDGNYTLYVLDNQNLQQLWTPGSLSIPVGKLYFAFNPKLCLSEIYHMEEIAGTRGRQDKADINPRTNGDRASCNTHILRFVSNWTEADRINLKWERYQPPDYRDLLSFVVHYKESPFQNITEYLGQDACGANSWNVVDVELPLNNEQEPGVTLTNLKPWVQYAIYVRAITLTTEEGQNFGAQSDVVYIRTKPAAPTVPQDVMIMSNSSSHLIVRWKPPTQRNGNLTYYLVLWQQMVEDKELYLNNYCTKGLKLPTSSADTRFDNDDNGNQDPNQDTEDKCCPCQKDGGLLPEMDEGSFQKKFENFLRNTIFIPKHPWKVTLINKDNQRPAKKRRDVSGMNPEVLSNTSLPEGTVSHTINHTGVESKPYSYKDKVFRDRMVISNLRHFTEYRIDIHACNHAADIVGCSAATFVFARTMQDPLADNIVGNITWEVTVKNNILMKWEEPKNPNGLILKYEIKYKRDHEEGPSTVVCVSRQKFQLNKGTYLTLLQPGNYSARIRATSLAGNGSWTEPVVFFILGPEEPSENLYLLLKIMPIFLLVVIAFLAVFIFFYNKKGNNNGYPNGTLYASVNPEYFNASDMYVADEWEFPRENITIIKELGQGSFGMVYEGVAKDIVKNEPVTQVALKTVNELATTRERIEFLNEASVMKAFLCHHVVRLLGVVSQGQPALVIMELMTRGDLKSYVRSLRPDEENNNPGNQPSLKQMIQMAGEIADGMAYLTAKKFVHRDLAARNCMVSEDLTVKIGDFGMTRDIYETDYYRKGGKSPLPVRWMSPESLKDGIFTTHSDVWSFGVVLWEIATLAEQPYQGMANEQVLHFVIDNGILEKPENCPDRLHALMRWCWQKNPKHRPSFIQILESIKDELHSSFQQVSFFNSKECKRRGSTETSDTEVDQSLNNLLDQTPSPSFTNCSSPTNSEKSNSLKAIAAKRDSSKNKNCYHMNGHAKL
97
K3XX03
3.2.1.1
ACT_SITE 202; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 227; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MGMGSRHMCCLSTLLLLLGLSSGQVLFQGFNWESSKQTGGWYNNLMGKVDDIAAAGVTHVWLPPPSHSVSSEGYMPGRLYDLDASKYGTAAELKSLIAAFHDKGVQAVADIVINHRCADYKDSRGIYCIFEGGTPDSRLDWRAHMICRDDAKYSDGTGNLDTGADFPGAPDIDHLNDRVQRELTEWMLWLKSDLGFDAWRLDFARGYSAEVARVYINGTAPSFVVAEIWDKMVPAGDDGKPAYDQDPHRQALVDWVDKVGGAASPATVFDFTTKGILNAAVEGELWRLIDTEGKAPGVIGWWPAKAVTFVDNHDTGSTQAQWPFPHDKVMQGYAYILTHPGNPCIFYDHFFDWGFKDEIAALVAVRKRNGITPTSELTILEHDGDAYVAEIDGKVIVKIGSRYDLGHLIPVGFEVATHGKDYAVWEKGGSEEVTRA
157
A7EZS5
3.2.1.23
ACT_SITE 184; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 283; /note="Nucleophile"; /evidence="ECO:0000255"
MRLLNIFTTLCLLLWSGAATNDGLTDVVEWDPYSLTINGDRVFIYSAEFHYQRMPVPELWLDIFQKFRANGFNTISVYFFWSYHEASKGSFDFETSGKNVQRVLDYAKEAGIYVIARAGPYCNAETSAGGLALWGSDGSMGTLRTNNAAYYQSWQPWIKEIGAILAKNQVTNGGPVILNQVENELQETVHSATNTLVLYMEQLETAFRAAGITVPFSHNEKGQRSQSWSTDYENVGGAVNVYGLDSYPGGLSCTNSNSGFSVVRNYYQWFSNYSYTQPSYFPEFEGGYFTPWGGSFYDECQSELDPSFPDVYYKNNIGQRTTLMSLYMAWGGTNWGHSAAPVVYTSYDYAAPLRETRQIRDKLSQTKLIGLFTRVSTDLLKTDMIGNGTGHSVSSTGIWSWVLRNPDTQAGFTVVQQASSGSRASVTFDVYLNTSLGAVTASDVNLNGRQSKILVTDYNFGNHTLLYASSDILTYGTFDVDVLVFYLEQGQIGQFALKTTSKLTYQVYGNSVFAANSSSTSTSQTFTYTQGAGQTVVQFSDGALVYLLDQPSAWKFWAPPTTSNPQVKPNEQIFVLGPYLVRNASISSGVAQIFGDNDNATTIEVYAGSSLTSIVWNGVSLSATKTKYGSYSASLPGTESRVISLPSLTNWESANSLPEKETSYDDSKWTVCNKTTTLSPIAPLTLPVLFSSDYGFYTGQKIYRGYFDGLTYTSINITCSGGLAFGWSAWLNGVLIGGNTGVATATTTNAVLDLTNFTSVIKSENNLVTVVVDYHGHDETSTAKGVENPRGILGAFLVPKPSASTGFKLWKIQGNAGGSANIDPVRGPMNEGGFYGERVGWHLPSSPSLPSDSTPLIGLNTSGISFYTTNFTLALDSDLDVPLGIKLSAPAGTIARVMFWINGYQYGKYVPHIGPQTVFPIPPGIINNQGSNKLALSLWAMTDAGARLTDVELVSYGVYESGFGFDRDWSYLQPGWDEGRLAYA
163
B7P6Q5
3.1.4.11
ACT_SITE 328; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 375; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MTKAYDFNWQRTIPDALLKGCIFDRWEEEKEQVVYEPGALFRVDEYGFFIYWNSEGRDGQVLELSQVNDIRAGGIPKDVRLLAELSSKNRYGLDEVSLTICSGTDMVNINYTHVVCPDPDTAKVWQAGLRSITNNIKANNVCPATCLEKHWIKLGFLVEPEGKLPVRRIAQTFASGKTEKLVYQCIADVGLPGGKNDVIEPKEFTLEKFQELYQRVCPRNDIEELFNTITEGKTDYITLKQFISFLNEKQRDPRLNEILHPFYDERRVREIVGAYETSPELVKEGRLSQGGLVRYLMSDENAPVFLDRLDMYMDMDQPLSHYYINSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDEEPIITHGKAMCTDILFKDVIYAIRDCAFVTSDYPVILSFENHCCKKQQYKLAKYCSEIFGDLLLTEPLPSYPLEPCVSLPTPNELKRKILIKNKRLKPEDEKRELELWKKGQLQNDDDEEEKEDASVTILAPTEEGEGEKKVSSPRDGRGWSTRYSTLTRSADGAVQVEAQLEEQLAMAHYQYTGATVHVHPFLSSLVNYAQPVKFQGFDVAEERSVHFNMSSFAETSALGYLKSQAIEFVNYNKRQLSRIYPKGTRADSSNFLPQIFWNAGCQMVALNFQTPDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKTFDPFAESPVDGVIAAQCSVRVLSGQFLSDKKVGTYVEVDMYGLPTDTIRKEFRTRMVPANGLNPVYNEEPFVFRKVPPSSSSSDSQLLRKQTQICEQAFTLSVISGYRHVSLRTEGNFPMSLAMLFICIELKIYVPDGLGDLMDALSDPRAFLSAQEKRMVQMRAMGIEEADILVNRPDLGSQQKKDDDKREEWRMEAITVDALRTEKDYVKLRRKQIKELEGLRKRHHKDKQQVQKQQCLAVEKLVPKDSPGPVSESEDGGVRALVVQQMHQWSSLLGTHRAQEWDLLRLHLTNQGQLLRSLMLKAQAQQMKQLDAKFERENKEMKMKQAKVSVETAREVSSDKTLRNKAERERRLREKNSNNTKKFIEERKSAALKQSKERERLKKIHEKQLHDLQREIDNGLELYNAAETEYKLCAKLECFV
153
A0A078FT38
3.2.1.1
ACT_SITE 221; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"; ACT_SITE 246; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001028-1"
MDEKYRQFTTEQQHGLSECKTTLLFPPRLLPHLHGFHLVVSGEHIHHIGFKWESWMKEGGFYNSLHNSIDDLSNSGITHIWLPPPSQSVSPEGYLPGKLYDLNSSKYGSEAELKSLIAALKQKGIKAVADIVINHRTAARKDDHCGYCYFEGGTSDDRLDWDPSFICRGDTNYAGTGNPDTGEDYKPAPDIDHLNPRVQKELSEWMNWLKSEIGFSGWRFDFVRGYAASVTKSYVQNTSPDFAVGEKWDDMKYGGDGKLEYDQEEHRSGLKHWIEEGGGGVLTAFDFTTKGILQSAVGGELWRLKDSQGKPPGLIGIMPGNAVTFVDNHDTIRPNSWAFPSDKVLLGYVYILTHPGTPCIFYSHYIEWGLKDSISKLVAIRNRNGIGSTSSVMIKAAEAELYLAMIDEKVIMKIGPKLDIGTLVPPNFVLAYSGLDFAVWEKK
157
F1QAH4
2.7.11.30
ACT_SITE 372; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037393-1"
MGLWTRTSALLCCFCLLQVQSLSPIKTNLCKWCDHSSPVCEDNVCMSNCSLTSYCFLAEEVCVAIWKKDNVSVSVRTLCYDPQHMLENIMLANYSSKECLMSPHPSEDGLLFICSCVGDQECNDRLIFDKGPNGFSKLKSKDVIPVVVISLVPPLLVAVIATMAFYLYRTRQPGKKPKEWGPRRTHYQSLDPAEGQANGIDFSAKRPSLSDDINSEMSSTCANNLNHNTEQLPIQLEALVGKGRFAEVWRARLSHNESGQYETVAVKIFPAVEYSSWCNERAIFSDANLKHENVVQFLTAEERGGTSATSQRQYWLIMAYYNMGNLQDFLVGNILTWAELCSLAGSVARGLAHLHSDTTPCGIQKVPIAHRDLKSSNIVLKNQSECVLCDFGLALRLDLSLTVDDFANSGQVGTARYMAPEVLESRVNLEDLESFKQIDIYSMALVMWEMVSRCDVIGEVKSYEPPFGSKVCEQPCVDSMRDLVLRDRGRPDIPDSWTTHSGMQLLCATITECWDHDPEARLTAHCVVERFNTLAQEELENSICTHTPSTPPTEDQTPTLPSHPPCTDHSADICPHVTADIVSSRQHSQV
106
A0A9R0JWY5
3.1.1.11
ACT_SITE 256; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MIILRVVVFSLCVLCVPLAEANQNDASITTTNVKLRVGEKEFFEWVNKIGFKTKSRSNKHKHNNNNNNNNNNNRMKFEQHKQQQKKKMKPCKTIKVRENPKPSSKHFGSVQKAISSLPILNSCRVVISVGPGTYREKVEIPRTMAYIKIKGAGADKTIIEWDDTADRLGQSGQPLGTYGSATFAVNSPFFVAKNITFKNVAPLPQTGALGKQAVALRISADKAAFIGCKFIGTQDTLFDHIGRHYFKDCYIEGSVDFVFGNGLSLYNACHLHAVSNHYGALTAQKRESFTEKTGFSFVNCRVTGSGGLYLGRAWGTFSRVVFAYTYMDKIIAPGGWYDWGDKNRDMTVFYGQYKCSGPGANYGGRVSWSRELTSQEAQPFISYDFIDGYEWLKNLI
125
A0A1Z5RCU2
3.2.1.14
ACT_SITE 90; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1"
MRAPAAVMAMVAIFAMSTSTAGGSVASIISESLFNQMLLHRNKPACPASGFYTYSAFVAAANSFPGFGTTGSPDAQKREVAAFLAQTSHETTGGWASAPDGPYAWGYCYKEEKDAAASAPEAYCRPSALWPCAAGKKYYGRGPIQISYNYNYGPAGEAIGAAGILDDPDLVATDATVSFETAVWFWMTPQPPKPSCHAVVTGQWAPSPADTAAGRLPGYGVVTNIINGGLECGHGADSRVADRIGFYKRYCDLLGVSYGNNVDCANQRPFNSGEGGHRIHLVSNTRCHGLA
158
A2EDM1
3.2.1.52
ACT_SITE 273; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MLYSIKPQLQFQAQLLSDYITQQTLMPVKYSGVISDKCSIILDIGYPDANEEAYKPTITSDSISINGSTEKGSFYGIQSLRKMIPVQKTPKKIKILTQEIIDRPRFSYRGLLLDVARYFRTVEEVKKFMDIMALHNMNFLHFHLTDDQGWRIEIPKYPDLTRIGSRRRQTKGDGIPISGFFTRKDILDLIEYGQSRQITIIPEIDLPGHAQSALTAYPKLGCTGGPYEVSERFEVHSDMLCYGNPESMVFIKDVLSYVMDLFPSKYVHIGGDEAEKSQWKACQKCQAKIRELGFVDDQISTKEDKLQRHLTIELSKIISSKGKEMIGWSEIAHGEKVENSIVMSWLRNKNNEMPEKDNYTVILTPTNPMYLDYLQEKRSNLNTLDKVYNYEPITENHNDNDVSRFMGIEACMWTEYTPTFESVMTKVLPRAAAVSVAQWSFPNLKNYQSFLGDLENLKKIYELNNYVYYADY
170
A0A804HWT3
1.11.1.7
ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MIASHLMELLLLIALLLFGVQLSVGSLTSNYYAAICPFAEFIVRNTVNQALRSDATLAGGLLRLHFHDCFVQGCDGSVLIDSTKDNTAEKDSPANLSLRGYEVIDQAKQMLENQCPGVVSCADIVALAARDAVFMSGGPYYDVAKGRKDGRRSRIEDTINLPPPTLNSTDLIEMFAKHGFTVQELVVLSGAHTLGAARCSSFKKRLSNFDPNNDVDPTLDSNYARMLSRSCSAGDDTQVGFDFTRTRFDVNYYYALQGRMGLLTSDQTLYTNPQTQYIVNGYAMNQASFFSDFQQAMIKMGALNVKEGNQGEIRRNCRQVN
14
Q6DR03
2.3.1.225
ACT_SITE 174; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250"
MARRHGWQLPAHTFQVVAITVFFLLTVAYYAFFAPFLGNKLYEYIAIGVYSFLAFSVLVLYIRCTGIDPADPGIFVKADNTPAHKSQNSNYVPENASAIDGGPYIRHGSGCCSAIGRFICGCLVIQDCRRDTQQEQSNEQEEALFCSLCNAEVRMFSKHCRSCGKCVDGFDHHCRWLNNCVGQKNYISFVCLMAASFFWLIAEFGVGVTVFVRCFVDQKAMEHLITEKLGLGFSRPPFAAVVVVCTTLSLLALIPLGELFFFHMILIRKGITTYEYVVALRAQTEPLGTSVDELDQTSQYPSPASSAVTATSARSSLGLSIQYRGASLCTPPNIFVDQQDDVIQHLEPGPVRSTIDPDSLSQKKPPQRQQVRINPWKLAKLDSKEASKAAAKARASSSVLLPVSSRQNPYKTSSNVSGRSSPGRGKPADSESCSLSSPGLTRDHFNPMYMSSPANESPLNEEESRNAVVAARRNLPSSDESSVVWDPEAGRFVSLSRIPGTDVGGPLGNECLNTITSTGTDRSRRARGNPLTGYFQQVRSQRGDQLPVFMPTDSQLHRHLSTRFH
57
A0A6I8NXU0
2.7.10.1
ACT_SITE 727; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MERRCPPGLGLALLLLCAPLPPGVPAKEVTLLDTSVAQGELGWLLDPPETGWSEVQQMLNGTPIYMYQDCPVLGTGEADHWLRSNWIYRGEVPTRVFAELRFTVRDCRSFSEAGSGPLGCKETFNLFFMESDQDVGIQLHRPLFQKVTTVAADQSFTVRDLAIGAMRLNVERCLLGRLTHRGLYLAFQNPGACVALVSVRVFYQRCPEIERGLARFPDTLPSPVGLTEVSGTCLPHAHPSLDPGPRMYCSPDGEWLVPVGECHCGAGYQDEEGECTACPRGFYRPDSDVRRCLKCPPRSSSSSEAATFCSCVTGYYRAPAEDAEVACTRPPSAPRNLSSSLVGTQLTLHWEPPGNTGGRRDISYSVTCTRYPGPEEGPCGGGVRFSPGASGLSETRVRVEGLEPYTNYSFRVDAHNGVSGLVTPETPGPASAASLSIRVGHAEPLVGLSLELVKQGPRQLELSWTGPRLLRSPAGTLRYELRVLNQDEERHETVSEPRVLLKELEPDTVYLVRVRALTPLGPGPFSPDHEFRTSRPLESEGLSGGEIVAVIFGLLLGLAFVFGLFVFCREKVWLKPYVDLQAYEDPVQGALDSTRELEPAWLTIDMVIGEGEFGEVFRGSLRVPGQDRVAVAIKTLKASSPDGQWWNFLREATIMGQFSHRHIVRLEGVVTKRKPMMIVTEFMENGALDAFLRAHEEQLGAGQLVSMLQGIASGMSYLNDRGYVHRDLAARNILVSRGLRCKVSDFGLSRLLENDTEGTYETQGGKIPIRWTAPEAIAHRIFTAASDVWSFGVVMWEVLSFGDKPYGDMTNQEVMKSIEDGYRLPPPVDCPAPLYELMKSCWAHERARRPRFRQIQAQLEQLLASPHALRTVADFDPRVTLRLPSVSGSDGIPYRSVPEWLESIRMKRYILHFRSAGLDTMESVLELTAEDLNQMGVTLPGHQKRILCSIQGFKD
97
B1L6R0
6.2.1.5
ACT_SITE 248; /note="Tele-phosphohistidine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_01988, ECO:0000256|PIRSR:PIRSR001553-1"
MAILVREGMRVLVQGITGRQGTIHTKLMLEYGTKIVAGVTPGKSGAKVYDVPVFDSVEEAVREKGPIDASIVFVPAPYAMDAVIEAVDNAIPLVVVITEGIPVHDTAKFVSYARSMGTTIIGPNCPGIIAPGKVKIGIMPADSFAPGPVGIVSRSGTLTYEISLSLKNAGYGSSTTIGIGGDPITGLNFIEVLELFKEDPETKAVVIVGEIGGDAEERAAKYIAQGYPKPVVAYVAGRTAPPGKRMGHAGAIITAGQGTVESKERAFSEAGVPVARTPFEVAPLLAERLRH
247
A0A0K9NPT2
3.4.19.12
ACT_SITE 23; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 23; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 128; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR633865-1"; ACT_SITE 143; /evidence="ECO:0000256|PIRSR:PIRSR633865-1, ECO:0000256|PROSITE-ProRule:PRU00331"
MDFGGSPSNGGLLYHEVQESKLCAVHCVNTVLQGPFFTELDLAALASDLDHKEREVIVSHDQDALSSHDFLSEDSHNVSMDGDFSIQVLERALEVWDLKVIPLDSPVAEPSKHDPELENAYICHLQNHWFCIRKVNGEWYNFNSLYAAPEHLTRFYLSAYLDTLKSSGWSIFLVRGNFPKDCPVSSSDPSYGFGQWLTPDDAKGITNSCNESGVTQRIESPHRIIQYKML
175
A0A0Q3K0V5
1.11.1.7
ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MLSGNMMKGNKQLGCLVAVAVLVLSAGSLDTAAAQAAGLKKGFYKKSCPQAEDIAQKVVWNRVAGNRELAAKFLRMFFHDCFVRGCDASVLLDSPTRTAEKDSAPNLSLAGFEVIDEVKAALERACPGVVSCADIVALAARDSVSFQYGKKLWEVETGRRDGSISSDQQALDEIPAPSSTFDVLASNFSSKGLGVQDLVVLSGGHTIGIGNCNLVSSRIFNFTGKNNPSDIDPSLNPPYAKFLQGQCRRNQADPNDNTTVVPMDTGSSTSFDSHYFVNLKAGQGLFTSDATLVTNARAASLVDKLQDNGVFLDHFKNSIKRMGQIGVLTGANGQIRNRCNVVNS
14
P25341
2.7.11.1
ACT_SITE 449; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTQQEYRSPSQRLSKGRSMSLPKIFARNLRSLQNNAPPGKNINVNCLNVNSCSLSASPSSQINMACNGNKQDLPIPFPLHVECNDSWSSSKLNKFKSMFNHNRSKSSGTTDASTSEKGTHKREPRSTIHTELLQSSIIGEPNVHSTTSSTLIPNEAICSTPNEISGSSSPDAELFTFDMPTDPSSFHTPSSPSYIAKDSRNLSNGSLNDINENEELQNFHRKISENGSASPLANLSLSNSPIDSPRKNSETRKDQIPMNITPRLRRAASEPFNTAKDGLMREDYIALKQPPSLGDIVEPRRSRRLRTKSFGNKFQDITVEPQSFEKIRLLGQGDVGKVYLVRERDTNQIFALKVLNKHEMIKRKKIKRVLTEQEILATSDHPFIVTLYHSFQTKDYLYLCMEYCMGGEFFRALQTRKSKCIAEEDAKFYASEVVAALEYLHLLGFIYRDLKPENILLHQSGHVMLSDFDLSIQATGSKKPTMKDSTYLDTKICSDGFRTNSFVGTEEYLAPEVIRGNGHTAAVDWWTLGILIYEMLFGCTPFKGDNSNETFSNILTKDVKFPHDKEVSKNCKDLIKKLLNKNEAKRLGSKSGAADIKRHPFFKKVQWSFLRNQDPPLIPALNDNGCELPFILSCNKHPKRNSVSEQETKMFCEKVANDDEIDEADPFHDFNSMSLTKKDHNILTYSENYTYGKILYKATCTRPRHNSSHRSFFKDIIPEL
99
A0A078IPB5
3.1.1.11
ACT_SITE 406; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MIGKVVVSVASVLLLVGVAIGVVVIINKNGNTPLSPQMKAVQGICQGTSDKASCVKTLEPVKSDDPNKLIKAFMLATQDALTKSSNFTGKTEGELGSSISPNNKAVLEYCKKVFLYALEDLGTILEEMGEDLNQIGSKIDQLKQWLTGVYNYQTDCLDDIQEEDLRKTIGEGIASSKILTGNAIDIFHTVVSAMAKLNVKVDDFKNMTSGVFSPSDKGAAPTGLPTWVSGADRKLMANAGRGRRRGGGGARIRANFVVAKDGSGQFNSVQQAVNACPDKNPGRCIIYIKAGIYREQVIIPKKKNNIFLFGDGARKTVITYNRSVGLSSGTTTSLSGTVQVESEGFIAKYIGFKNTAGPNGHQAVAIRVNGDRAVLFNCRFDGFQDTLYVNNGRQFYRNCVISGTVDFIFGKSATVIQNSLIVVRKGNKGQYNTVTADGNEKGLAMKIGIVLQHCRIVPDRKLAAERLTVESYLGRPWKQYSTTVIMNTEIGDLIRPEGWRVWDGENFHKSCRYVEYNNRGPGANTNRRVNWAKIARTAGEVNQFTVANWLSPVNWIQQANVPVTLGF
125
P39118
2.4.1.18
ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 352; /note="Proton donor"; /evidence="ECO:0000250"
MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVWAPHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRLKADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKKHSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGPPHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGTANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLKKLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPEERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGYMTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKILYEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFTQYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGEIKR
73
O23447
3.1.1.11
ACT_SITE 520; /note="Proton donor; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"; ACT_SITE 541; /note="Nucleophile; for pectinesterase activity"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10040"
MNKYVLLGVTALIMAMVICVEANDGNSPSRKMEEVHRESKLMITKTTVSIICASTDYKQDCTTSLATVRSPDPRNLIRSAFDLAIISIRSGIDRGMIDLKSRADADMHTREALNTCRELMDDAIDDLRKTRDKFRGFLFTRLSDFVEDLCVWLSGSITYQQTCIDGFEGIDSEAAVMMERVMRKGQHLTSNGLAIAANLDKLLKAFRIPFPFLRSRRGRLGILGSGSSRDESVGSSQDSPPNEDSSDDSPSTVDSSENQPVDSSSENQSSDSSNNRPLDSSKNQQMESSEDTPKKSAFSGNQPLDDSSDKLPQKSTSSENQPLDSSENPPQKSTSSENRPLDPLRKLNPLNKLDSLKDRHLSEEGEFPPWVTPHSRRLLARRPRNNGIKANVVVAKDGSGKCKTIAQALAMVPMKNTKKFVIHIKEGVYKEKVEVTKKMLHVMFVGDGPTKTVITGDIAFLPDQVGTYRTASVAVNGDYFMAKDIGFENTAGAARHQAVALRVSADFAVFFNCHMNGYQDTLYVHTHRQFYRNCRVSGTIDFVFGDAKAVFQNCEFVIRRPMEHQQCIVTAQGRKDRRETTGIVIHNSRITGDASYLPVKAKNRAFLGRPWKEFSRTIIMNTEIDDVIDPEGWLKWNETFALNTLFYTEYRNRGRGSGQGRRVRWRGIKRISDRAAREFAPGNFLRGNTWIPQTRIPYNAN
125
A0A9R1XN79
3.1.1.11
ACT_SITE 424; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSRTTDFFSEGLDSGMQINLSNKRKKLFLTAFALIILLASALIGVIVGVKSRNSGFDNSNPESITDSEAHAIVKSACSSTFYPELCYSTVTSHPDVTIKVKNLKNVIELAVNITVTAVEQTYFQIKKLTTRKGLTKREITALHDCHQMISETLHELLDVMKGLQKYQTKESLRHHANDLKTLMSSAITNQETCYDGFSHDEADKNVRKELEQGERRVEKMCSNALAMICNMTNTDLAEEMKLNARKLKEEVNTEWPGWLSAGDRRLLQSGTVKPNVVVATDCSGNYRTVADAVAAAPSHSRTIYVIKIKAGVYHENFEVPSTKTNIMFVGDGRKSTIITGSRSVKGGSTTFNSATVAVVGDRFLARDITFQNTAGPSNHQAVALRVSSDLSAFYQCDMLGYQDTLYVHRGRQFFINCYIAGTVDFIFGNAEVVFQGCDIHARRPGPAQMNMITAQGRTDPNQNTGIVIQKCRIGATSGLQPVQSRFPTYLGRPWKEYSRTVVMQSVISDVIHPAGWYEWNGNFALNTLFYGEYQNTGAGAETSGRVKWGGFKVITNYADVQRFTPESFIGGGRWLHATGFPYSLGL
125
P84155
1.3.3.3
ACT_SITE 107; /note="Proton donor"; /evidence="ECO:0000250"
MSLAVEAVKDFLLKLQDDICEALEAEDGQATFVEDKWTREGGGGGRTRVMVDGAVIEKGGVNFSHVYGKGLPMSSTERHPDIAGCNFEAMGVSLVIHPKNPHVPTSHANVRLFVAEREGKEPVWWFGGGFDLTPYYAVEEDCRDFHQVAQDLCKPFGADVYARFKGWCDEYFFIPYRNEARGIGGLFFDDLNEWPFEKCFEFVQAVGKGYMDAYIPIVNRRKNTPYTEQQVEFQEFRRGRYAEFNLVIDRGTKFGLQSGGRTESILISLPPRARWGYNWQPEPGTPEARLTEYFLTKRQWV
27
Q0D847
2.7.11.1
ACT_SITE 181; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9JIH7"
MMGALQQQSNGHGHGVLLLAEAGYAEVDPTGRYGRFNEILGKGSSKIVYRGFDEWRGVEVAWNQVRLRDVVRGGGELERFYGEVHLLAALRHRGIVRLHAYWVDAPRRALNFVTELFVSGTLRQYRERHRRVSAAAVRRWCAQILDGLAYLHAHSPPIIHRDLKCDNIFVNGNQGEVKIGDLGLAAFRRGGGHARCVGTPEFMAPEVYDESYDELADVYSFGMCVLEMVTLDYPYSECSNPIQIYKRVISGIKPAALYRVSDPVVRQFIERCLAPAARRPAARELLDDPFLLPLEDDGFFSGDGGDGHGGFGVGYYNLMYNYLHQPACIDDHHACSNGGLSPSNSVGDNDVDAAVQRGDDDGDNWLRDIHMLFDEDDDDAAAADANERVGGVDITIKGRRTDDGGVYLGLRIADKNGTGRGRIICFRFDTEADTAMTVAAEMVAELDITDHEVTRIAQLIDGKVAALVPGWRPGPATDDDDDDDLVGGGDDPDAPGGAAAACCKNCRPAASSSSSCGSLVDFMSSAAAAERHGCRRCAELHGRFEEITFQADDDEEEQHLQGSSSDTGGSNHEQHAMGKDKEVMNINGIAQDGTVQGSEQP
99
O84096
5.4.99.25
ACT_SITE 45; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080"
MELATESIEGVLLVDKPQGRTSFSLIRSLVRLIGVKKIGHAGTLDPFATGVMVMLIGRKFTRLSDIMLFEDKEYAAVAHLGTTTDTYDCDGKIVGRSKKVPTMDEVLTCTSYFQGEIQQVPPMFSAKKVQGKKLYEYARQGLSIERRFATVTVNLRLVKYEYPRLHFVVQCSKGTYIRSIAHELGNMLGCGAYLEELRRLRSGSFSIDQCIDGNLLDEPGFDVSPYLRDANGLILQPAPVL
218
Q8PCF2
2.7.1.107
ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600829-1"
MADQLGHVPRGPRRMLKAAVWSWQGLRAAWLHESSFRLEVCLAALLTPLALWLGNSGLERIALIAPLLIVLAAELLNSAIEAVIERYGPEHHVLAGRAKDMGSAAVFVLLINVLLCWGLVLLPRLF
83
G1KCW7
3.5.1.98
ACT_SITE 826; /evidence="ECO:0000256|PIRSR:PIRSR037911-1"
MNSTNESDGVSGREPSLELLSRAQIHAIPVAAVDLKPVLPVVMQSSCNSSSSSSPVDLRMDARPSVPTIDPAAREQQLQQELLALKQQQQLQKQLLFAEFQKQHEHLTRQHEVQLQKHLKQQQEILAAKRQQELEQQRKREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLKLQEFLLSKSKELASAGGLNHSLPQHSKCWGAHHTSLDQSSPPQTGSPGTPPSCKLPLLGTYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAIEITVSSMCNSAPGSGPSSPNSSNSAITENGLTGSVPNIHTEQMLPQHRAVNMDGSANQLSLYTSPSLPNISLGLQATVTVTNSHLNASPSLSTQQEAERQAIQSLRQGGALTSKFLSMSSIPSCLLGVALEGETNNHGHASLLQHVLLLEQARQQNTLIAVPLHGQSPLVTGERIPSNLRTVNKLPRHRPLSRTQSSPLPQSPQALQHLVVQQQHQHFLEKQKQQQIQLGKIITKTGELPRPPTTHPEETEEELTEQQETLGLGLSQGPFLVDGSTESEETQDDLEEEDKVVEEEEEEEVVEEQVKDEAGENKLEEEQEVEELGVTYRQVFADAHQLRHLQLYQTPLSISTLPHQALSRTQSSPASTSLKSSTVEPAANHLFTTGVVYDTFMLKHQCTCGNTNVHPEHAGRIQSIWSRLQETGLLSKCERVRGRKATLDEIQTVHSEHHTLLYGTSPLNRQKLDSKKLLGPLTQKMYTVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVASGELKNGFAVIRPPGHHAEESTAMGFCFFNSVAIAAKLLQQKLAISKILVVDWDIHHGNGTQQAFYSDPNVLYISLHRYDNGNFFPGSGAPDEVGSGMGVGYNVNIAWTGGVDPPIGDVEYLTAFRTVVMPIANEFSPDVVLISAGFDAVEGHLSPLGGYSVTAKCFGHLTKQLMELAGGRVVLALEGGHDLTAICDASEACVSALLGLELEQLDQTLLQQKPNANAVATLENVIEIQSKHWNSLKRFAALVGCSLLEAQKGEAEEAETVSAMASLSVDTEQGKAECDVRQVEEPMEAEPVL
184
Q8EE98
1.1.1.49
ACT_SITE 240; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00966"
MGKTTSGAKACDFVLFGTKGDLARRKLLPSLYQLDKAELLDKDTKVIGVAKDEFSQDEYRDLVILALKTFVKEPLCEDTLNRFVSRCYYVGTNFTESAGYGAFHELLKPEERVMVSYFATPPSIFGDICRCLHEQNLIHSDSRVVLEKPIGSDLASSRIINDQVSAYFKESQVYRIDHYLGKETVQNLIALRFANSLFASKWDNRTIDHVQITVAEEVGIEGRWGYFDKAGQMRDMIQNHLLQVLTLVAMDPPVNLDADSIRDEKVKVLKSLRPINADNVYENTVRGQYSAGFLKGSPVPGYLEEEGANVQSHTETFVALRVDIDNWRWAGVPFYLRSGKRMPFKSSEIVVYFKNPPHNLYRSSYRNLPPNKLTIRLQPHEGVEIQMMNKVPGLEQKQRLQTTKLDLSFSDTFKNERIADAYERLLLEAMLGNQALFVRRDEVEQAWTWVDGIIQAWEQSNEKPKPYPAGTWGPVASVALITKDGRSWDE
6
Q8A1G3
3.2.1.1
ACT_SITE 388; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 431; /note="Proton donor"; /evidence="ECO:0000250"
MNKHLHFLSLLWLSMLMAFMTACSDDKNITDPAPEPEPPVEGQWTALTASPDTWDETKRADISYQLLLYSFADSDGDGYGDLNGVTQKLDYLNQLGVKALWLSPIHPCMSYHGYDVTDYTKVNPQLGTESDFDRLVTEAHNRGIKIYLDYVMNHTGTAHPWFTEASSSSESPYRNYYSFSEDPKTDIAAGKIAMITQEGAAGYNAAEWFQVSDETAAVKGLLKFTLDWSNAPSPILVVSTGTKADEDNPDTGTDNAKYLYYGEDICKKFYDKGNNIYELTVDFESTWGLLIRTSNASFWPSGTKYGASSSSEKLALNKDFKLTNAGNPANIMFDSQQITYFHSHFCTDWFADLNYGPVDQAGESPAYQAIADAAKGWIARGVDGLRLDAVKHIYHSETSEENPRFLKMFYEDMNAYYKQKGHTDDFYMIGEVLSEYDKVAPYYKGLPALFEFSFWYRLEWGINNSTGCYFAKDILSYQQKYANYRSDYIEATKLSNHDEDRTSSKLGKSADKCKLAAAVLLTSAGHPYIYYGEELGLYGTKDNGDEYVRSPMLWGDSYTTNYTDKTDATVSKNVKTVADQQADTHSLLNIYFSLTRLRNTYPALAEGNMTKHSVYNESQEKDYKPIAAWYMTKDNEKLLVIHNFGGTAMQLPLTDKIEKVLFVNGETQQNTDSDSYTLKLGGYASVVFKLGN
157
A0A8V0Y4W4
2.3.2.26
ACT_SITE 1209; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MAHRLRFHFGSGRSNTAPESEILDREREDDFFMAFHTLPRRSSPHAFSRHGADYGGGSEFQEVGSLKRSTSMFIPQLLNSISARPTRSSSMQISLQRKAADECATPETPEETPLCKASDVRERYASPVENHSSSRSSPEVTPEDSPPRQTEELGQQMNGTLRCNRRVFRTIPPNSQSDDALSTARENEAKETASGLNISGVRIQHRASSADVPQVTLLPFGSEAQNNAPTPEPRRWSLQHVPDMSANSGKKFFVLQLQQPQAGGTGGEYNFGFTGTKGDRLVRYPRIQLERSASYPVQPRPEEIRPTGDGLTSELHGNGRSGSHISRSNSVEKIPQGKGCLFKIRPDQNTRQQHFRILVTRNPEEQSPVVGTECRGTAGPAAASTATRDDFLGQVDVPLSHLPTEDPSMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQEEENSDQRDESEHGWDVVDSSDSASQRQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLIDVGSDSDNNIRQINHEAAHRRFRSRRHISEDLEPEPLETGDIPEPWEAISEEASATGDTLSLSLPPPPASPVSRSSPQELSEELSRRLQITPDSNGEQLSSLIQRDPSSRLRSCSVTDTVAEQSQLSLPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGMVGSAANNNNHLSEPQIRRPRSLSSPTVTLSAPLEGMKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVAQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHLRTKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNNKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVYHGKLLDGFFIRPFYKMMLGKPITLKDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGTPDKLPRAHTCFNRLDLPLYESFDDLREKLLMAVENAQGFEGVD
65
A8X6B4
3.1.3.16
ACT_SITE 186; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1"
MSAPKLTDSQKKVRGFVNRIIGKLMFKWKHTTSMELFCAAELAELCIRARELIWAEPICLKLETPICVMGDLHGQFDDLLGMWDSNGWPLTEKERNWFMEKTLKTKRMPCTEPKSSQPDSNPNGPRSSGGWDEKPVLKEVKDLGYKRYLFLGDYVDRGMYSMEVVILLIAIKMAYPDRLYMLRGNHESRSVNCHYGFYREVTRRYDAKLYEYFSDLFNVFPFCAIIEDTIMCMHGGISEQLMNLSQLALYKRPVEIPDMGVLADLTWADPDPTVKRYAPSSRGASSVFGSQALREFLKRLNLRLVIRAHQVVEDGYEFFDNRRLITVFSAPNYCGQNDNSAGILCIDQSLKISIVVYRPMVRDRKFFGKEKRTKVPAKVNE
144
A8XU89
1.1.1.8
ACT_SITE 231; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000114-1"
MPCQNFDYCFNNNSDELRGDSRKKIAIVGGGNWGSAIACVVGKTVKAQDDVFQPIVSMWCRDSRKPGDTTPSIAETINATHENPKYLPGRRIPSNVIATSSLLDACESAHILILVVPHQGIPQICSELRGNLRDGAHAVSLTKGISSTSENDVIRMQLISEDIEKALGVECSVLMGANLAGEVADGKFCEATIGCKSLENGEELKMLFNTPNFRIRVTTDYEAVELCGALKNIVACAAGFADGLGWAYNVKSAIIRLGLLETKKFVEHFYPSSHHTYFESCGVADLITTCYGGRNRKVAEAFIKSDKPLHIVEQELLKGQSAQGPPTAQDVFEMLEIHEITEKFPIFTSVHKIFTGEHGEQELYDSLRNHPEYD
7
A0A251UPS6
1.11.1.7
ACT_SITE 109; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MSTSTLSSSILFITNSNISLNHLHQNLKFQTPPESSLLPTMAAKNTTIFSFFSTLIFFGLIHSNQIDALNTNYYDHTCPNVESTITSVVKKAMMNDPTVPAALLRMHFHDCFIRGCDGSVLLNSTGKNKAEKDGPPNISLHAFYVIDNAKKALESLCPKTVSCADILALAARDAVTLSGGPTWDVPKGRKDGRISKATETRQLPAPTFNISQLQQSFAQRSLSMDDLVALSGGHTLGFSHCSSFQNRIHNFNSKQSVDPALQSSFAARLKSICPAHNTVKKAGANLDSTPTTFDNRYYKLLLQGKSIFSSDQALVTMANTKTLVSKFASSQHEFEKAFVKSMIKMSSIHGGQEVRLDCRVVN
14
A0A8M6Z1G5
2.7.10.1
ACT_SITE 671; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MMMKKMMKMQSSGGPAALSGCCVRWRVRCSGLCALLIAAVLRCCSANSDLRFVESPGNVTSSLGKPVSLQCVLQAFGLDEEPLDLLWLRDGRTLEYADTNQIQMLEEDHSWTVISKLTIEEVQLLDMGAYRCVLYSGEEETSSAEGYIQLEGLPHFSVEPQDRSAVANEPLSLRCEAHGPPEPVRVIWLQDGAPLNELDDPVALSPSTLNISGLNKSSSFSCEAHNRKGVASSATGVVTVLPSPPSAITADEISNSSIRLSWHSGFGGVYPISHCSVQVQDSSGSLVQDQQVSGVVGVCVISDLQAFSQYEVRLQCRSSQGPSSWSQWRPVSTAEGVPESAPENVTAVLNGTEVILSWSEVSGRINGRLQGYMLEYSTPNEEQAVLDVGLDTEQSVNLSEPLSNISFRVCAYTGAGPGPWTAQHTLTLIPTETGQSRGSPTPAVFSWHWWYVVMAVAVAVALAVLLAVYGTRLRRKETRFGEAFEPMMESGELVVRYRARRTYSRRTTEATLNSLGISDELKQKLQDVMVDRHRLTLGKTLGEGEFGSVMEGSLSQEDSVLKVAVKTMKIAICTRTEMEDFLREAACMKEFDHQNVMRLLGVCLQTVESEGYPSPVVILPYMKHGDLHSYLLYSRLGDSPVYLPAQMLVKFMTDIARGMEYLCRKNFIHRDLAARNCMLNENMNVCVADFGLSKKIYNGDYYRQGRISKMPVKWIAIESLADRVYTTKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPPDCLDSIYSLMFSCWLLSPKDRPSFEMLRCELEKVLEDLPSQDPEEILYVNMEESSGELGATGGLPCALGALKGSVATVEVHPPSRYVLCPQLENQRLLSAHSTDSLELPGLGADLDPEPEPQPSSCSTPLPERQSPELEPHSRRAAWH
97
Q81ID4
3.4.21.89
ACT_SITE 39; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 78; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MMQKKKRWREFFGTIAIACLLVFLAKIFVFFPTTVKGASMRPTLQDGDKVIVNKLAKQFESYGREDIIVMKTDNFYVKRVIGLPGDIIEMRNDQLYVNSEVKDEEYLDSNKKQAEKKLMNLTEDFGPITVPENKIFVMGDNRLISKDSRNGLGFIDREDVLGKLAGIYYPFEHMKIIK
178
P54560
2.7.7.7
ACT_SITE 108; /evidence="ECO:0000250"
MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGVVLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVEPYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNFAKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLLKKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLELSEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFLTFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAASLTAAGQAFERAAKIGGHYK
121
A0A8I5ZUV2
2.3.2.26
ACT_SITE 663; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104"
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPSRQNQLKDQQQQQVVSLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKANTRLKHCTPDSNVVKWFWKAVELFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE
65
Q9RU23
6.3.4.2
ACT_SITE 383; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 517; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 519; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"
MKYIFVTGGVVSSLGKGVASASLGALLRARGYKVTAVKIDPYINIDAGTMRPYEHGECFVTASGAETDLDIGNYERFLDLDIPAGSNITTGQVYQEVIRKERAGDYLSQTVQVIPHVTDEIKRRIRAAGESAGAEIVLIEVGGTVGDIESLPFLEAIRQFRFDEGDDNVLYLHLTLVPYLGTSNEFKTKPTQHSVAALRSYGISPDIVMVRSKDKLPAEITRKIAAFTSVRENRVFSSYDVEHVYQVPLALEEQGLGKAVEELLGLEGTHPRLGVWTDAVRTIKHPKQQVTIAIAGKYTAMPDAYLSLMESLTHAGIANDARVNIKWVNAEQLAEAGAGELEGQFADVDGILVPGGFGIRGIEGKVKAAEYARTHGVPYLGICLGMQIAVIEYARHVAGIEDANSAEFDEYAKNKVIDLMPEQLEVAGMGGTMRLGDWPMELRAGTKIAELYGVPQGGTVKERHRHRYEVNPAYVEQLEAAGLTISGVTPGVEGRGAGLVETVEIADHPFFVALQAHPEFKSRPMRPSPPFAGFVKAALEHQQQ
252
Q5JHL8
3.4.25.1
ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_02113"
MEKKTGTTTVGIRTKEGVVLAADTQASLDHMVETLNIRKILPITDRIAITTAGSVGDVQALARMLEAEARYYQFTWGRPMTAKAMAHLLSNILNENKWFPYMVQIIIGGYVEEPTLANLDPLGGLIFDDYTATGSGSPFAIAVLEDGFRKDMSLEEAKELAVRAVRTAGKRDVYTGDRKVQVVVISKDGMKEEFVEFKE
180
A5D6R3
3.1.4.11
ACT_SITE 328; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"; ACT_SITE 373; /evidence="ECO:0000255|PROSITE-ProRule:PRU00270"
MLGRKKNPETVQTESKSVESKTHDPLRRLGVLDDEDVLLMLQGSKMMKVRSQRWRKDRRLKLLEDCVTVWCESSKTSRKSNRQQTFSVTEVECVREGCQSECLRRMTDLVPEKNCFTVVFRGGRKSLDLCCHTQEEAERWVRGIRTLKDRVSNMSQKEKLDHWIRGYLRRADQNQDGKMSYDEVKHLLQLINIDLNEQYARTLFKKCDRSCDGRLDHVEIEEFCREMMRRPELDAVFRHYSGNGCVLTTLELRDFLGDQGEDASLVHAKSLIQTFELNDWAQKNLFMTQNGFTMYMLSKENDVFNPDHTHVYQDMSKPLAHYYISSSHNTYLTKDQVTSASSTEPYIRALNQGCRCVELDCWDGDKGEPIIYHGHTLTSKVLFKEVIETIAQYAFKASPYPLILSLENHCSVEQQAIMAQQLQSILGKKLLAKPLSDLPLKQLPSPEELKGRILLKGKKLNGLLGKTESWTSFTNSSDEESVAGGNKKESKKDLARSASTKLSPELSDLVVYCQSVPFSGFETANQRPPSVITSFSENEALKLIKDSGKLFVRNNSRQLSRIYPSAQRLQSSNFDPQDMWNAGCQMVALNFQTPGEQMDLNQGRFLPNGRCGYVLKPEFLCDPKSDFDPENTGGGPGHIPTQLTIRVISAQQLPKINTDKPNSIVDPQVWVEIHGVSIDKARAKTQRIDNNGFNPRWDCTVSFQLQLPELALVRFMVEDHDHKSKNDFIGQFTLPFTSLRTGYRHVHLLKADGSTLSPATLFIHVKVVRRGVHIKTVSERIGKA
153
F7DBN2
3.2.1.52
ACT_SITE 300; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
MNERTNGLWASPRPARDGRWQGGRQYAAGSALQPGCSVLDQAFGRYLRLLFGPGPPPRPAEAGEDQASDSTLTVSVDNPGCDGFPSLKSLENYTLNLADDQFSLKADEVWGALRGLETFSQLVWRSAEGTYFVNKTEIVDFPRFPHRGLLLDTSRHYLPLSSILETLDVMAYNKFNVFHWHVVDDPSFPFESVTFPELSRKGAYNSATHVYTPEDVKIIIEYARLRGIRVLAEFDTPGHTLSWGLGAPGLLTPCYVGPMLSGTYGPVNPILNSTYEFMAKLFSEISSVFPDFYLHLGGDEVDFTCWRSNPDIRDFMEEVGFGQDFTKLESLYIQRLLSIVSSYSKGYVVWQEVFDNGVKLKGDTVVHVWRENAGSYLKELEAVTNASYRALLSAPWYLNRIGYGQDWIEAYKVEPLQFEGTPEQKALVIGGEACMWGEYVDATNLTPRLWPRAGAVAERLWSSEAVRDLQSAYLRLTDFRCELLRRGVQAQPLYTGFCKQEFFWL
170
F4NYD5
3.1.3.16
ACT_SITE 104; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1"
MDMAVNWQYEMRRDMQEIIPGLWLGPYSCARDNSLLHLKGITHILCVRESNEEMMVRMRFPEEFHYLCIQASDSPLQNLIPLFPKATSFIHTAITNGGSVLVHCNGGISRSPAFVVAYMMDMHDMQFATAFQFVQSKRFCMNPIEVFKYQLR
144
Q0V4Q5
2.5.1.18
ACT_SITE 13; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1"
MSGRITSYLDCVSPYSYFALLRLEENRALLKEHNVEIDIVPVFLGGINVGSGNKPPWTLPAKGAYGRYDSERSKRYFGVPNIKTPEFFPILSLLPQRALVYVKEAHAQKFIQAFKDIFQGIWEQGLDVSKPELLAQVLSKQFSETEVRDILEKANSAPYKQRLNDNTKEALDLGAFGCPWHVLRNSKGVEEPFFGSDRFHYMWEFLGLPWKDIELQAPGSAKTKARI
77