Entry stringlengths 6 10 | EC number stringclasses 260
values | Active site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q4WP34 | 2.5.1.18 | ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1" | MAAPKITLYFDVVSPFAHIAFHVLKHSPTFAKCDITYVPIFLGGLLKACGSTPPIQIKNKAQWINQERRRWARYFSVPIVEKTPPGFPALTVAPQRALCAISKKAPERFVPAVEALFQSYWVEGNGQIGQPEGFGPVLEKVLGKDSTEQILKAMSQYEAKSLLLANTDRAFKSGAFGLPWFECTNPKGETEGFWGIDHLGQVAEFLGLDRSLDKGFRAVL | 77 |
A0A3B6QE31 | 1.11.1.7 | ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAAVPLPLPVMLLVAVAVMLVGAGAGAAGVRGGRQRQQQLRMGFYDKSCPAAERIVGDYVRLHVRRVPTVAPALLRTHYHDCFVRGCDGSILLNSTAAGAAEKDAPPNLTLRGFDLIDRVKGLVEEACPGVVSCADVLALAARDAVAAIGGPSWRVPTGRRDGTVSTMQEAVRELPSPSMTFPQLVALFAGKGLDVRDLVWLSGAHTIGIAHCSSFADRLYSYPSAGNGTGTVPPLDAAYAANLRQRKCRMGGRDAAVEMDPGSFLTFDLGYYHTVLKHRALFRSDAALVTDAAARADIAGVVSSPPEVFFQVFARSMA... | 14 |
Q24145 | 2.7.10.2 | ACT_SITE 789; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MSRDSDPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSG... | 98 |
A0A1S3Y125 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAALLCKRNAKSLIFSSIICFLIQITALNGQLRVGFYSQRCHNAESIVSSVVKEASQGEPRMPAMLLRLHFHDCFVQGCDGSILIDNVKEAERNAFGHEGLGGFEEIEKAKTRLEAQCPGVVSCADIVALAARDAIVLLHIYILRYVDDSIDVLKGKFKNKGFTEKELVILSGAHTIGTTACFFMPRRLYNFTGRSDADPTINSKFLPELRSKCPKNGNINFRIPLDNASERKFDDQILHNIKNGFAVIASDARLYDDKITRAVIDSYLQRKKSIPNSPSFARDFGLTMIKLGRLDVKTGLVGEIRKVCNSFNKM | 14 |
Q8EHN5 | 3.1.1.29 | ACT_SITE 22; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MSEIKLIVGLANPGAEYVQTRHNAGAWYVEELARICGVSLVADSKYFGLTARAVLHGKDVRLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQELINAAVDEAVRSTEILFKEDMVKAMTRLHSFKAE | 127 |
F4KGQ0 | 4.1.2.13 | ACT_SITE 217; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P00883"; ACT_SITE 259; /note="Schiff-base intermediate with dihydroxyacetone-P"; /evidence="ECO:0000250|UniProtKB:P00883" | MSCFKSKFAGKSYFRRTFHSSIIQFHPQLSILIWHRRYSIIRTYELIANAAYIGTPGKGILAADESTGTIGKRFVSINVENVESNRRALRELLFTTPGALQYISGIILFEETLYQKTASGKLFVDVMKEAGVLPGIKVDKGTVELAGTNGETTTTGLDGLGDRCKKYYEAGARFAKWRAVLKIGNNEPSELAIHENAYGLARYAVICQENGLVPIVEPEILVDGSHDIEKCAYVTERVLAACYKALSDHHVILEGTLLKPNMVTPGSDSGSKVKPEVIAKHTVRALQRTVPAAVPAVVFLSGGQSEEEATVNLNAINQLK... | 197 |
A0A1D6F267 | 1.11.1.7 | ACT_SITE 113; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKVAALTITLLGLLVSVTCQGSIYSAQQQQDASSSSSSPGCILRGWIPFLHPCRDGQPPTPNPLPPPSGAGLTVGYYKNCPGAEGIVRKAVEKAMDNGNRGIGAGLIRIFFHDCFVRGCDASVLLRNTSGSSDQTEMFGLPNINSLRGFQVINDAKAELEKACPRTVSCADIVAFAARDATRNLSYGAIDFQMPAGRLDGRVSLKEEAEKNLPGPFDSLDDLQKSFAAQGLGFNDMVTLSGAHSIGVARCRFFTNRLPPNPSDMDRDLARSLKATCDQNGLDSKVVQDPVTPVALDNQYYKNVHNGKVLFTSDAALNST... | 14 |
A0A2K1J295 | 2.3.2.26 | ACT_SITE 1209; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MVLSVLALSIWGLFRCMRQITSVQSSRVHNRPSTASSSLNMEVISLREDDRVERTQREIHAALLHNPVMAERSHTVRERELTLERGLEIQDREAHFMSSARAQALVSPVGLRSTSSKRKLDDYEIGVAESSVSATSQVRARRETREDVQEGSVTESSGRERFEIGLLVGAAEAQPLDGESQMREEDGNAALDDDSTWEDEPNWNLSSSEEIGESSKEPPDKIEDSSRAEEDRRLEEVSEDHGSTLQVVLGGPTMVVDSGSNPYEFTLTSDPTNRSSTGVSLSSLGVNDVGRVEVEAGHSGSNEGRTDDLASSDVQIEGET... | 65 |
O84874 | 2.4.1.18 | ACT_SITE 399; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"; ACT_SITE 452; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685" | MDPFFLNTQHVELLVSGKQSSPQDLLGIVSESLNQDRIVLFRPGAETVFVELRGKIQQAESHHSGIFSLPVMKGISPQDYRVYHQNGLLAHDPYAFPLLWGEIDSFLFHEGTHQRIYERMGAIPCEIDGVPGVRFIVWAPHAQRVSVIGDFNGWHGLVNPLHKVSDQGVWELFVPGLTAGACYKWEMVTESGQVLIKSDPYGKFFGPPPWSVSVVIDDSYEWTDSEWLEERIKKTEGPMNIYEVHVGSWRWQEGQPLNYKELADQLALYCKQMHYTHVELLPVTEHPLNESWGYQTTGYYAPTSRYGSFEDLQYFIDTMH... | 73 |
Q8WML3 | 2.3.1.48 | ACT_SITE 599; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q9H7Z6" | MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKSTKESRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPK... | 61 |
A0A6I8N5A1 | 2.7.10.1 | ACT_SITE 668; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MGRSPGCPAPCPLLLLLLLLLLSWGRGRARDALEAVFLENPQNLTTSLGKSARLRCSIRLGGEPPEVSWLRDGHPLDLADSNQVQVPMSDDDDWMVTSELSISSLQLSDAGIYQCSVLVAGNQLLSRSAHLGLEGLPFFSEEPEDLVVGAATPFNLSCSAQGPPEPVQLLWLWDGVPLHSLLDVLARPPSTLSLSGLNKTSSFSCEAHNAKGVTTSRTATVKVLPQRPTHLRLVSSSPTELQVSWEPGPSGIYPLTHCTVQAVPSDGSGAGGSDTPRGEPHTLGTEVPPYALRLDGLQPLTAYHLRVACASAQGVSPWTH... | 97 |
A0A9K3JCY0 | 3.4.21.89 | ACT_SITE 129; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 179; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MFHKIICNSTNSKIKMVSSHLLHLSSLHNPKLTFNFNNAGSKPITKTPNFASFCSPKRYNRDLVCYGSKEEVNGGGGGDGNEEKKDGLLLLPDWIDFSLDDVKTVVVAVAVSLAFRAFIAEPRFIPSLSMYPTFDVGDRIVAEKVSYYFRKPCPNDIVIFKSPPVLQKAGYTDDDVFIKRIVAKAGDVVEVHNGKLIVNGVVRNEDFTYEAPKYEMNPVRVPENYVFVMGDNRNNSYDSHVWGSLPSKNIIGRSVLRYWPPARIGSTVLPGGCAIDQPENTNSSLESQQDTSKLASQ | 178 |
A0A061GKR2 | 3.1.1.11 | ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSISVARFVASGSKKKLFLALFASVLLVTAIVSIATTLSVSKRKSSNNNSNNAAHSIIKSSCSSTLYPELCLSTISAAPDAETKIKSPKDVIVTSMNLTITAVQSNYLSIKKLISTNKNLPKREKTALNDCLELEDETLDELYKAEQDLSDYPTFNKSISQHADELKTLLSAAMTNQETCLDGFSHDSADKKVRQALIDGQMHVFHMCSNALAMIKNLTDTDMASQGYPSGRQLEEQDETEWPEWLSAGDRRLLQAPTVTPDVTVAADGSGDFRTVSEAVAAAPERSTRRYIIKIKAGVYKENVDVPRGKTNLMFVGDGR... | 125 |
E9GEM5 | 2.7.11.1 | ACT_SITE 158; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1" | MATVAPASSSGVATPSSQMALMDCETFGRTYHVGHVLGKGGFGTVYAGNRIRDGLPVAVKHIHKSSVTTWSHVNGVRVPLEFCLLRQVAHVPGVVRLLDACDADDVFVLVMERAESSQDLFDFITERGALPEQAARNFFRQVVEAVVQCHRAGVIHRDIKDENILVDLKTHCLKLIDFGSGDYLKDGVYTEFDGTRVYSPPEWIRHRRYHGRPATVWSLGILLYDMVCGDIPFEQDDQIVRATVNFVTRSPGRLRLSPQCEDLILRCLEYRPADRPSLEHILAHPCSNDDVMRYIKTARVHLYPSLIGINFRQHC | 99 |
A0A067F997 | 4.1.1.17 | ACT_SITE 354; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MGGQRVTTVVTKEELTEFVRSTILKRQEFDEVPFYILDLGVVVTLYNQMISKLPMIHPHYAVKCNPEPALLEALAALGSNFDCASRSEIEAVLALGVSPDRIIYANPCKPVSHIKYAANVGVNLTTFDSVEELHKIRKWHPKCDLLIRIKPPDDSGAKHPLDSKYGVDHHPQEIVPLLEAAEASGLSVVGVAFHIGSAATKFAAYRGAIAAAKAVFETAARLGNNKMRVLDIGGGFSFTNSNTKSFQEAASIIKEALHAYFPNELLPGSSLRVISEPGRFFTYSAFTLYTQIIGKRVHGEMRNYWINDGKYGSFDWVNYD... | 195 |
A0A1U8AWU0 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASLRLLSVFLCQLLVLLFLFDPSSAQGLKVGFYKDTCPRAEEIVRRTTAQYVTHLPSLAAPLLRLHFHDCFVRGCDGSVLLNATSANPNPEKTAIPNQSLDGFFVVDVAKSRLEKECPGVVSCADILALVARDAVKLVNGPFWDVPTGRRDGTVSLALESLANLPPPFFNITSLKLSFLSKGLSVKDLVVLSGGHTIGQSHCPSFTNRLYNFTGKGDSDPSLDSNYVPRLKSACQPGDTTTQVEMDPGSYRTFDASYYKLVAKRRGLFQSDSALLNDAETKAYVFEAAGSGSTFFKDFGVSMVNMGNIGVLTGTAGEIR... | 14 |
Q9LW83 | 2.7.11.1 | ACT_SITE 652; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MWSNCIFLTLFTFYLFLGQSCCQTDTLLQGQYLKDGQELVSAFNIFKLKFFNFENSSNWYLGIWYNNFYLSGAVWIANRNNPVLGRSGSLTVDSLGRLRILRGASSLLELSSTETTGNTTLKLLDSGNLQLQEMDSDGSMKRTLWQSFDYPTDTLLPGMKLGFNVKTGKRWELTSWLGDTLPASGSFVFGMDDNITNRLTILWLGNVYWASGLWFKGGFSLEKLNTNGFIFSFVSTESEHYFMYSGDENYGGPLFPRIRIDQQGSLQKINLDGVKKHVHCSPSVFGEELEYGCYQQNFRNCVPARYKEVTGSWDCSPFGF... | 99 |
W5MBJ6 | 3.1.3.1 | ACT_SITE 123; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | CSGTFHNMIHRMEQSMVLGLLAAFLLTGVLSATPMQEKDPAYWNTQAKETLQAALKMKPISHRAKNIILFLGDGMGVSTVSATRILKGQMEGNSGEETVLTMDTFPHLALSKTYSVDMQVADSASTGTAYLCGVKANAKTVGVSAAAVAYKCNSTFGNEVYSVLHRAKAQGKSVGIVTTTRVQHASPAASYAHSVSRSWYSDADLSSSALRDGCKDLATQLVFNTDIDVILGGGRMYMTPKGTPDPEYPTSSSRRGKRKDGKNLIELWLEARKSKNAQYVWHKEQFDAVDVNSTNCLMGLFEAKDMRFELYRNSTRDPSI... | 141 |
Q9VLR2 | 3.5.4.5 | ACT_SITE 80; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MTHLTKNFARPEKNEEVVTFGSLDPSVQELLTAAFQVRQRAYVPYSGFKVGAAFRAKVDGKIFTGCNVENAAFTPGSCAERTAIAKAVSEGATEFLAGAVLAYEPNVFTTPCGVCRQFIREFANADIPIYVAQAIDARIAEKQELLQSDDPVMCTSIFNLLPSSFHTYRK | 187 |
Q55CY9 | 2.7.11.1 | ACT_SITE 1158; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MINKILIKLITIIIFCFSFLFAEEDLIRTPPGYYNLTRHKRYPHITEYQSSQDTDLYYPDVCRNALRNDIIPGVDEFFPFLFPGFNSDGPNSIYIQKNSSLLFKSESLGTTYNFVAVCVEGSFTVKGSMFFTINSLIILPGGRFESEAGIEFYDENDPLHIYNNPDFPKDPFGFFPGILVLGGTISVVAKESLVYRADRISNSSIEISPPFSPMNKINQTIRIFTELYPLGFYCSFSSDLERKILSLLDCLPISENDKIIRVLIEVDRDQNVSPTNILKKGKTTKGSIYITGDSNVYFKNMFFKNLGFTTNEPYNDTKLI... | 99 |
Q8RGM4 | 2.7.1.23 | ACT_SITE 52; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MIKLSIIYNEDKEDAIKIYKELLKYLKSKKEFEVLDDKNISQAEYIVVIGGDGTLLRGFKKIKDKKVKIIAINSGTLGYLTEIRKDGYKKIFENILKGKINIEERYFFTVKIGKKKYNALNEVFLTKDNIKRNIVSSEIYVDDKFLGKFKGDGVIIATPTGSTAYSLSAGGPIVTPELKLFLITPIAPHNLNTRPIILSGDVKIVLTLVGPSEFGIVNVDGHTHNKINIEDKVEISYSKESLKIVLPDDRNYYNVLREKLKWGENLC | 89 |
Q9Y6R4 | 2.7.11.25 | ACT_SITE 1463; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGT... | 105 |
Q944Q0 | 2.7.11.1 | ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9JIH7" | MASGSGFLGQISSMEEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSALLASSSTSSKYVRPPQLEHLPMDVD... | 99 |
A0A2K1YEP9 | 3.1.1.11 | ACT_SITE 395; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEKANTATMATMNTPLLATPKTSRRKTICLVLSMVAILSSTTLVTMRYYTKTDPSSPPGLLQNLCDHAYDQESCLAMVSQIASNTSTKMSQVGLLQLLLGKSTPHIQNTIEKAKVIHSRINDAREQAALGDCVELMEISKYRIKDTIVALERVTSKSHANALTWLSSVLTNHDTCLDGLNGPARSTMEPDLNDLILRARTSLAILAAISPSKENNDIFSLKEDFPSWLPSMDRKLLVALPKDINADVTVAKDGSGKYKTVKEAVASAPDNGKTRYVIYVKKGTYKENVEVGKKKKNVMLVGDGMDSTIITGSLNVVDGST... | 125 |
A0A067H583 | 3.1.1.11 | ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASKLFFVITIPILIALLPVFARPSHATDVAPTTPVSAGSVCKSTPDPSFCKSVLPNQTANVYTYGRFSIRKALWQSRKFLNLVDKYLTRRATLSTTAIRALEDCRLLAGFNMDFLLSSFETVNSTSKTLPTMQADDVQTFLSAILTNQQTCFDGLQDTASAWSVKNGLSLPLSNDTKLYSVSLALFTKAWVPKKKKATAWQPTRKQRLFRNGRLPFKMSEKTRVVYETVSRRKLLQAAPDDEVLVSDIVTVSQDGSGNFTTITDAINVAPNNTDVTNGYFLIYITAGVYEEYISISKNKKNLMIIGDGINQTVITGNRS... | 125 |
Q54IP4 | 2.7.11.1 | ACT_SITE 298; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNDKISKLESSILQLTEEVKQLESKQASKELEIRTLVDNAINSQNPAQERELINKLFTESLIDLKLKAEKIQTLERYRQEIITNLLVEQKQPNDTSIISAWEQLKISSFRINPNNNNNNSNNTNSSDSNQNYSSVILNGSLTEDSTSTISPDSTKNRDEEEIIRWEIDRNEISYNREAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACTAPEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRAILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLS... | 99 |
I1JWX6 | 5.1.3.3 | ACT_SITE 188; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 320; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MFKVYLVSSFLLGLLLLAQAHGNDKKIGFYQLKRGDLHLNLTNYGASLISVIVPDKHGNLDDITLGYDDIEQYKNDSWYFGATIGRVANRIGHAQFTLDGHTYKLPANDHGNTLHGGFKGFSDVVWTVKSHKEDDHITFTYDSHDNEQGFPGRLEVSVTYMLIGTNKYSLKMIARPIDKATPVNLAHHTYWNLKGQNSGDNILSHEVQIFGSKITPVDKELIPTGKFESVKGTPYDFLEPREVGSRINDLPGLYDMNYVLDASSPYHFRKVIIVREKVSGRKLELWSNQLGLQFYTGGMLNATKGKDGAIYHKHGGMALE... | 211 |
Q5JI50 | 5.4.99.25 | ACT_SITE 213; /note="Nucleophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_01893" | MIVEKASEVLERYQLCDHCLGRLFAKLGKGTNEERGKAIRFVLNMERAKDGLPPVEEPKECELCNNVFDRIPELVENMKEAAKDVEFETFLVGSRFPDEVKEKEKAIWDEFGIETAEPINREFNRELGKAFGRATGKDTSKSPDVVFIVEPYSGKIELQINPLYIYGRYRKLLRGIPQTPHPDFEESVASIICRPFSRATGGKCVFKGAGREDVDVRMLGNGRPFILEIKRPKRRNINLEEIAREINASGKVEVLNLRFTTPDEAERVLSTPHRKEYLALVLVKEGVTPEEAEEVAKKLTGLEIHQRTPWRVRKARADKV... | 218 |
Q818G0 | 3.5.4.5 | ACT_SITE 55; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MNSKQLILEAIEARKQAYVPYSKFQVGAALLTRGGKVYRGCNVENASYGLCNCAERTALFKAVSEGDKEFVAIAVVADTKRPVPPCGACRQVMVELCKQDTKVYLSNLHGDVQETTVGELLPGAFLAEDLHE | 187 |
F4P5T8 | 1.1.1.205 | ACT_SITE 351; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 449; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1" | MASDNSVNKRQALDPVVKDVKKSKTEIDINQPTIDGLSAKELFDVRISGGLTYNDFLILPGYIDFPASAVSLETRITRRFTLKTPFMSSPMDTVTETNMAIHMALNGGLGVIHHNCPIEEQCDMVRKVKKFENGFITDPKCLSPSHNVQDVLDIKRKFGFCGIPITADGKMGSLLLGIVTSRDIDFLQSDNDQQKLLKDIMTTDLVTANQGISLVEANRILSESRKGKLLIVDANGHLTALLARSDLIKTRDHPLASKRDSRQLLCAAAISTHNEDKIRLAALVAVGLDIVVLDSSQGNSSFQIEMIKYIKKTHPQIDVI... | 3 |
H2MAB6 | 2.1.1.320 | ACT_SITE 451; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR015894-1"; ACT_SITE 460; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR015894-1" | MAPVSLSLRKKSLLNQSTEVMASASTGSRVSCGRDMNCVPEIAATLAAVAKLGFDFLCMPLFHPRFAREFELEPAKSRPGAQTRSDLLLCGRDWGTLIVGKLSPWICADSEIETERRNSEEALTQELNFSAYLGLPVFMIPLTGPHNANLARLLLSHIHTGHHTSNFWIRVPLMAAEDTREDLIENEPFSCPDETSVDEKTWNWWNTFRTLCDYNKRICLAIDIGADMPSDAVIDKWMGEPIKAAILPTSLFLTNKKGFPVLSKAHQRVIFRLFKLEAQFIFTGTSRHTEKDFRSYLQYLEYLNQNRPAPNAYELFAKGY... | 44 |
A8J537 | 1.11.1.6 | ACT_SITE 65; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 138; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MDPAKIRPSSAYNTPYWTTNSGAPVWNNNNSMTVGTRGPILLEDYHLVEKLAQFDRERIPERVVHARGAAAKGFFEVTHDISALTAADFLRAPGVQTPVIVRFSTVVHERGSPETLRDPRGFAVKFYTREGNFDMVGNNMPVFFIRDGMKFPDMVHAFKPNPKSHIQEAWRIMDFLSHHPESCHMLTFLLDDAGIPLNYRHMPGFGVHTMKLINKAGRETYVKFHWVPKCGEKYLLDDEAVMVGGANHSHATKDLFDAIAAGDYPEWALMVQTMDPADEDKFDFDPLDVTKTWPESLFPMQPVGRMVLNRNVDNFFNENE... | 13 |
G0HV10 | 6.3.4.2 | ACT_SITE 391; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 517; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 519; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605" | MPTEPETDYDPELGRKFIFVTGGVMSGLGKGITAASTGRLLKNAGFDVTAVKIDPYLNVDAGTMNPFQHGEVYVLKDGGEVDLDLGNYERFLDIDMTFDHNVTTGKTYQHVIEKERSGDYLGRTVQIIPHITDDIKRRIREAAEGNDVCIIEVGGTVGDIEGMPYLEALRQFAHEEDEDDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDILVGRCSDKLDIDTKEKIALFCDVPTEAVFSNPDVDDIYHVPLMVEEEGLDQYVMEELDIATEALPEDERENRWRDLVTQNTEGEVDIALVGKYDLEDAYMSV... | 252 |
A0A078ITL9 | 3.1.1.11 | ACT_SITE 394; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSKLSCITLCQKKVILFATTSSHYSLEEEKKMYNPSRKTSKHINLNLLALTFHLIFIISTVHSQSTQRLTEPNSITELIVATLNQTILNVNVSYTSFFNLQKRLGPNIAHRYRCAFEDCLGLLDDTISNLETAIFKLQTSSVGTHDVNMLLSDAMTNQDTCLEGFTTSGIHENNNDNTYKLTDILKDSILKISSNLSDSLGMLQKIPRHKHSKEAYEVDVEFPSWVLENDKRRLHAPVKEIKFNLMVAQDGTGNFTTINAAVSAAPNSSATRFVIYIKRGVYFENVEIPNKKTMIMFVGDGTGRTVIKANRYSTPHGRTT... | 125 |
Q6P3R8 | 2.7.11.1 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCKIQKVRFQGKCPPRSRISVPI... | 99 |
O76039 | 2.7.11.22 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVES... | 102 |
Q9JZP5 | 1.8.1.4 | ACT_SITE 456; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MSQYDVVVIGAGPGGYVAAIRAAQLGFKTACVDAGVNKAGNAPALGGTCLNVGCIPSKALLQSSEHFHAAQHEFAEHGITVGDVKFDAAKMIERKDAIVTKLTGGVKFLFQKNKVTSLFGTASFAGKNGDAYQIEVDNKGEKTVIEAKHVIVATGSVPRPLPQVAIDNVNVLDNEGALNLTEVPAKLGVIGSGVIGLEMGSVWNRVGAEVTILEAAPTFLAAADQQIAKEAFKYFTKEQGLSIELGVKIGDIKSEGKGVSVAYETAAGEAKTEVFDKLIVAIGRIPNTKGLNAEAVGLEKDERGFIKVDGECRTNLPNVW... | 36 |
Q9C660 | 2.7.11.1 | ACT_SITE 554; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MTTPAQAPREEVSLSPSLASPPLMALPPPQPSFPGDNATSPTREPTNGNPPETTNTPAQSSPPPETPLSSPPPEPSPPSPSLTGPPPTTIPVSPPPEPSPPPPLPTEAPPPANPVSSPPPESSPPPPPPTEAPPTTPITSPSPPTNPPPPPESPPSLPAPDPPSNPLPPPKLVPPSHSPPRHLPSPPASEIPPPPRHLPSPPASERPSTPPSDSEHPSPPPPGHPKRREQPPPPGSKRPTPSPPSPSDSKRPVHPSPPSPPEETLPPPKPSPDPLPSNSSSPPTLLPPSSVVSPPSPPRKSVSGPDNPSPNNPTPVTDNS... | 99 |
Q8Y9X7 | 3.2.2.27 | ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00148" | MVKTWEEFLKQEAKQPYFIELMEAVKDARAKGNVYPSEEDMFSCFRLCPYNQVKVVILGQDPYHGPGQAHGLSFSVQKDVRIPPSLRNIYKELKTDLDIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTDHVLEELNNYDKPLVFILWGNHAIKAASGITNPQHLIIKGVHPSPLAASRGFFGSKPFSKTNAFLEEHERKPIDWDLNEQ | 173 |
D6WSZ3 | 2.7.11.1 | ACT_SITE 741; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1" | MSSEESTESRQNNELEALQAIYGDDLRDLRGKSAWNAWTPLNLSISLNPQQGSSGLHEVYVKLDLHVTCPETYPNTVPVIKLENSKGLSDNSLIQLQKILEEKADKLRGEEMIFQLAQHVQEFLHLHNKPASKSFYDEMLQRQKEKEEKDLQAKLMEEDRERQFVQQEVQKRQEILKLESRMRRYNSENSDDSDQRRRSISYNSNENSDESLCSHKKTVIVEFTNREIKRGQCLKHCSYNHVVFIGMDVKTGEIVLLSEWIITNRKYLSSLEQEFNYLAKLKHQNLAHYLSFKYEGHADGAVVHILKEYVSGPNCSFFMN... | 99 |
Q9Z2P5 | 2.7.11.1 | ACT_SITE 143; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSVKLWLNGASSISLVGSEELENLGFVGKGGFGAVFRARHTAWNLDVAVKIVNSKKISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGSLSGLLQPSCPRPWPLLCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDPELHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREAEVVDKTSLIRGAVCNRQRRPPLTELPPDSPETPGLEGLKELMTHCWSSEPKDRPSFQDCESKTNNVYILVQDKVDAAVSKVKHYLSQYRSSDTKLSAR... | 99 |
A0A2R6WPU5 | 1.11.1.7 | ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTLFRRDCQALSVLLGLWLCTLARATSVGDISPQWVKGSLSIKFYEQTCPQLDGIVKAAVTQALNTDLTLAGSLVRMAFHDCFVRGCDASLLLDSTPAQQAEKTAGPNQNSLRGFNVYDAIKNAVETVCPGVVSCADIIALVARDSVVATGGPTWPIYLGRRDGIVSSQQEANSQIPAATLGYSQLMAAFANVGLSQHDLVTLSGAHTLGRAQCFLFSNRLYNFTGQGDTDPTIDATFAAQLKAACPPNSPTASFVPLDSTQNIFDRNYYTDVLAGRGVFQSDAALLTARYPLSIITAISQDPTNFFKDFPVSMNRMLAI... | 14 |
P32944 | 2.7.11.1 | ACT_SITE 579; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSSLDEDEEDFEMLDTENLQFMGKKMFGKQAGEDESDDFAIGGSTPTNKLKFYPYSNNKLTRSTGTLNLSLSNTALSEANSKFLGKIEEEEEEEEEGKDEESVDSRIKRWSPFHENESVTTPITKRSAEKTNSPISLKQWNQRWFPKNDARTENTSSSSSYSVAKPNQSAFTSSGLVSKMSMDTSLYPAKLRIPETPVKKSPLVEGRDHKHVHLSSSKNASSSLSVSPLNFVEDNNLQEDLLFSDSPSSKALPSIHVPTIDSSPLSEAKYHAHDRHNNQTNILSPTNSLVTNSSPQTLHSNKFKKIKRARNSVILKNREL... | 99 |
O94737 | 2.7.11.24 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MDSKHSVFNVMGQEFVLQKGYEVIKGLGKGSYGVVCSAKNIEVEDNNKVAIKKITNIFSKKMLAKRALREIMLLQHFRNHKNITTLYDMDIVDPSKFNELYLYEELMQANLNSIIRSDQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPSNLLINADCKLKICDFGLSRGISVNQGQGTEYMTEYVTTRWYRAPEVMLSFQSYSKAIDLWSVGCILAELLGRKPFFKGSNYVDQLNQIFCILGTPNENIISKIKSASAQSYIRSLPTLPKMPYSKIFPYANPDALDLLNCLLTFDPYDRISCEEALEHPYLIIWHDP... | 104 |
A0A7M7SV91 | 2.3.1.48 | ACT_SITE 518; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MGRRKKEDSDSSERWESDSSVDVEEVSTSDEDQGNRRITRQSTRIVTRATNQVMRMRGQSPMKTGKGVDRKTSDSSDSEPTVPPTDTAAEKTNNKKGRKRGKSETHHSDTESGASLNGGGPKKKIQKKSTGKGDAKLTNGELSSDKESGDGDKKRRSRIIAEQQLLKSENVELRCPVPGCDSRGHFTGKFTKHRTLWGCPLYHNMTAEECQAKADARAEKRRNRHQEQENDEKKALRQTNSSRAQQQKRYQVQELRRQRKELTEDVKVKSRQHREEFHKSREPLLNGITSQFDLDLFREAQMRASEEMVRVHAQSLPKHD... | 61 |
A0A061DQB9 | 1.11.1.7 | ACT_SITE 99; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKGKKKGRKKKTNYQVEQAHRQATIGCYRLKDIRMKSHILILLCIVVLGVIGSCQGDGIGKNYYKVTCPHAEEIVKNVTEKHVCKNPSLPAKLLRMHFHDCFVRGCDASLLLNSTTNNTAEKQAIPNLTLSGFDVIDDIKAEVEKTCPGVVSCADVLALAARDSVSFELQRPLWEVLTGRRDGRVSRISEALANIPSPFSNFTTLVRNFASKGLDVHDLVVLSGGHTIGIGHCNLFSNRLYNFTGRGDQDPSLNPAYASFLKTKCRSLRDIITTVEMDPRSSLNFDNHYYVILKQKMGLFQSDAALLTDDSALKTVDELL... | 14 |
E9HCA8 | 2.7.11.13 | ACT_SITE 370; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MQLKLRPTGRLNVQVRHFREGDGPVLDGDDFSLGGGGITRRRGAIKHHKVHEVKGHKFVAKFFRQPTFCAFCRDFLWGFGKQGYQCQICQCAVHKKCHDKILGKCPGSGKESQNTIYLRERFKIDVPHRFRVHNYMSPTFCDHCGSLLYGLFRQGLKCEVCNVNCHKKCERHMPNLCGVNQKLLAEALSSVKRGSSNKSPPTSVKSESSSTSKKATKISQSTSRGTRCEPPIKTKPKFRKYGYDDFQLVKVLGKGSFGKVMLAELKGTGSYFAIKCLKKDVVLEDDDVECTMIERKVLALGTKHPYLCHLFCTFQTESHL... | 100 |
C8VN86 | 1.1.1.34 | ACT_SITE 103; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 236; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 312; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 408; /note="Proton donor"; /evidence="ECO:0000255|PROSIT... | MPESQIIELGTLGQIPLYSLERALQDPLRAVKLRRQIVSQHQATGNIDFTTDGSALPYEGYDYKAVLGACCENVIGYMPIPVGVAGPIKINGKMVFLPMSTTEGALVASTNRGCMAINAGGGVTALVLGDGMTRAPIVRFPSLEEAGAAKQWLGSDAGFLIIEDAFNASSRFARLQNIKATAVGSDLYIRFTASTGDAMGMNMISKGVEQALEAMQKHGFESMDVVSLSGNFCADKKPAAVNWIEGRGKTVTAQATIPEHAVRETLKTSVEALVELNVSKNLVGSAVAGALGGFNAHAANVVTAIYLATGQDPAQNVQSS... | 4 |
H2L8K1 | 1.11.1.6 | ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 148; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MAENRDKTTDQMKTWKENRGSRKPDVLTTGAGHPIGDKLNLQTAGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYCKAKVFEHIGKTTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTDEGNWDLTGNNTPVFFIRDALLFPSFVHTQKRNPQTHMKDPDMVWDFWSLRPECLHQVSFLFSDRGLPDGYRHMNGYGSHTFKLVNADGDRVYCKFHYKTDQGIKNLSVEEAEHLASTNPDYAIGDLFNAIANGNYPSWTFYIQVMTFEQAEKFQFNPFDLTKVWSHKEFPLIPVGRMVLNR... | 13 |
G7ZZU2 | 2.7.1.11 | ACT_SITE 224; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MDGSSSSSSSSSLELEDVTNLFEPIKLKDLPHLNHYISNLKTFPNPLDQNPYFHTPQLQHFYITNNNLVFSHSTRFAYRTAGPRNNVFFNPSDVRAAIVTCGGLCPGLNTVIRELVVGLWDLYGVRQIFGITAGYRGFYSSSTQPVQLNPNIVHHWHTKGGTFLQTSRGGFDLCKIVDAIQNQAFNQVYIIGGDGTMRGAVKIFNEIKQRKLNVAVVGIPKTVDNDVGIIDRSFGFQTAVEMAQQAISAAHVEAESAVNGIGLVKLMGRSTGHIVLHSTLSSRDVDCCLIPELDFYLEGKGGLFEFLDQRLKENGHAVLV... | 84 |
A7SE05 | 2.3.2.23 | ACT_SITE 98; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MATTSSNVENFSPQIIKQVAREIHGLTNDPPEGIKVFSNDEDITDIQASIEGPTGTPYEGGIFKIKLVLGKDFPAAPPKGFFLTKIFHPNVAKNGEICVNTLKKDWKPDLGIKQVLLTVKCLLIVPNPESALNEEAGKLLLERYDDYSKRAKMFTEIHAKLSASSSNNISEGQQESLPGKKRVAVNEKMCDKKKKDKKRALKRL | 64 |
Q8IYP2 | 3.4.21.4 | ACT_SITE 56; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 101; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 195; /note="Charge relay system"; /evidence="ECO:0000250" | MKFILLWALLNLTVALAFNPDYTVSSTPPYLVYLKSDYLPCAGVLIHPLWVITAAHCNLPKLRVILGVTIPADSNEKHLQVIGYEKMIHHPHFSVTSIDHDIMLIKLKTEAELNDYVKLANLPYQTISENTMCSVSTWSYNVCDIYKEPDSLQTVNISVISKPQCRDAYKTYNITENMLCVGIVPGRRQPCKEVSAAPAICNGMLQGILSFADGCVLRADVGIYAKIFYYIPWIENVIQNN | 177 |
Q4V7Q6 | 2.7.11.1 | ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAAGWAPPRLEDFILTEKLGSGSYATVYKAYRKRNAREVVAIKCVSKKSLNKAAVENLLTEIEILKTVHHPHILELKDFQWDQDYIFLITEYCAGGDLSRFIRTRRILPERIVQVFLQQLASALKFLHEKNISHLDLKPQNILLSRLDRPHLKLADFGFAQHMSSEDAPQALRGSPLYMAPEMVCSKHYDARVDLWSVGVILYEALFGKAPFASKSFSELEEKILSHKTIELPTRPRLSPECRDLLQQLLQRDPDKRISFIEFFAHLFVDLEHMPSAETLEKATRLVVEAVEKDSAGEHSAALTLYCKALEYFIPALHYE... | 99 |
A0QJI1 | 3.1.3.3 | ACT_SITE 187; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 189; /note="Proton donor"; /evidence="ECO:0000250" | MNSPPKVSVLITVTGVDQPGVTATLFEVLSGHGVELLNVEQVVIRHRLTLGVLVCCPADVADGPALRHDVEAAIRKVGLDVSIERSDDVPIIREPSTHTIFVLGRPITAAAFGAVAREVAALGVNIDLIRGVSDYPVIGLELRVSVPPGADGALRTALNRVSSEEHVDVAVEDYTLERRAKRLIVFDVDSTLVQGEVIEMLAAKAGAEGQVAAITDAAMRGELDFAQSLQQRVATLAGLPATVIDEVAGQLELMPGARTTLRTLRRLGYACGVVSGGFRRIIEPLAEELMLDYVAANELEIVDGTLTGRVVGPIIDRAGK... | 147 |
H3GAG9 | 4.2.1.11 | ACT_SITE 242; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 377; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSKPSLLQRTCWCLVCAFKSDLTFLANGSGRNHHLFLSIHAREIIDSRGNPTVEVDLTLSGSAEIFRASVPSGASTGIHEAVELRDGGKRYAGKGVQQAVQNVKSVLAPKLIGADPTKQRDIDNLMREIDGTENKGKLGANAILGVSLAVAKAGAAAKGVPLYQHFADLIGNKNLVLPVPSFNVINGGSHAGNKLAFQEFMLLPTGAESFSEAMVMGCEVYHQLKSVIKKKYGQDATNVGDEGGFAPNIQSNREGVELLMTAIGRAGYDGKIGIGMDVASSEFLTKEGKYDLDFKTEGSTDLLTGEELGQLYKDLAKEFP... | 200 |
F7FU03 | 3.4.19.9 | ACT_SITE 131; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 241; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 241; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MGSSWQRLCALGTVLLCFVRGDVPREDINERPIIGILAQSHKEDLQGLGKYYIAASYVKYLESAGARVVPIRTTLSDEEYDNLFNSINGILFPGGGVDLQTSKYSYVARLFYDKAKQAFKRGDYFAIWGTCLGFEELTVLTSGKQLLTPTNTSGIALPLNFTKAINESRMFQNFPKDLLVALATEPITSNFHKWSLSLKTFMENKKLSEFYTVLSTNTYKGIEFISTMEAKEYPIYGVQWHPEKNAFEWKKLKGLVHSPVGIRMSFYMADFFVNEARKSHHRFASKEEEEKALIYNYEPVFTGNYSSFQQCYFFD | 176 |
A0A3Q7GG70 | 1.11.1.7 | ACT_SITE 234; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVGKARIFAGLFLICIVLPSLASAFVDHLPEVGQVNDNNDVPIHVSTVAHFSEKQVKEAMIRRAKAVHDLWANFGNNDKDDVAKEDAAPVTPTPVDSTPTTTPVDPTPTPVDPTPNPGPVNPVPADPTPNPVPANNVPAGYPGATQGPPVAMGYGGAPITQNPSDQQTVPEQAGAAQNHPTPEEIKEQRKHAGLQVGFYDSTCPNAEKIIKDGMNRAFGNDSSMAAPIGRLLFHDCFVNGCDASILLDKTPSGARVEKLAPTNGATIRGFELIDEIKAELEAECPGIVSCSDLLVYLSRDAFVVSGVPYYDVPGGRRDGM... | 14 |
A0A1U8II71 | 3.1.1.11 | ACT_SITE 367; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDKLVVILTFFLTHFFIFPLGNFVNGTTITSCTQTPYPDVCNFYMGNSLNVAANLDQTQFSFRDVAIQVTLSQAVQAHQLVSSMDSSSFDQRAKLAWNDCVELYEDTIHLLNLSKNTKNPIDSQTWLSAATANQQTCQNGFIDFNLASHLQTLPSMLGNFTKLISNSLAINKATTVTSSTSHSNFAKQVANRRLLSDGFPAWLSVADRKLLQTTGAPPKADIVVAQDGSGNFKTITEAVAAAGGGKRTVIYVKAGVYKENVDIKRAAKNIMLIGDGIDATIVTSSKNAQTTTTFRSATVGVSGDGFIARDMTFENTAGPQ... | 125 |
P34101 | 2.7.11.1 | ACT_SITE 342; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNSNKEETTADGSVSTTEEQQQQQQPQQQEQINTTTASTTSNGENTASDNNNNSNNNNNNNTNNTNTNNNCDISMTEDNSKEEDTGIKVIGEGELWGKLISLNPTYPTIEIRQDSIILGRSKGVCNYTFTSPTVSGKHCKIYRDPTVKSRNVAFVDDTSTNGTFINNEVIGKGSKILIENGCEISVIPKKGSEKISFIYQDCFEEQKEMEQGGPQQKYDLREVLGTGNFASVRLGVEKETGNKYAIKIIDKKKMSMTSKRKDSLMDEVNVLTKVKHQNIISIKEVFETQKNLYLVLELVTGGELFDKIVSERKFQEDTCR... | 99 |
A0A804J208 | 3.1.1.11 | ACT_SITE 135; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQQFLRWWWWLLLWALSCCVFSTDGAANITRVIIVDQSGQGNFTTLQSAIDSLPDGNSQWIQIYIKQGTYRRNNLASWQNTFKSGSERHLQAVAALVGGDRNSFHDCAFIGYQDTLCDYRGRHHFDKCWIEGAIDFIFGFGQSVYSRCVLNSVDGGWLTAHAKTSADSPGGFVFKYCTIRATKMTYLGRAWNQHSTVLFHKTWMPSTIRPEGWDAWHVIPNQYQMTYVEDGNIGAGSNTSGRVSWLKSLPPEQLQGFLSSIEFLGPDRWFDKQP | 125 |
B9RR25 | 3.1.1.11 | ACT_SITE 444; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDTEENTNSMKSYSKIEEAAQSEEAFRRKTRKRLMIIVLSVLVLLIIVTGSSIGILASRNKSKDLSSPTYSANSNIRTLCNVTRYPESCYSSMSSAIKASSNGENPNPQTKELFLLSLKIAFDELMNLSSLPQKIISSQNYRNEINDPLLQSALRDCETLFNDAIDHIKESISSMQVGGGNTSKIIDDIRTWLSTAITDQETCIDGLKEAGKHLTLTNEVRYAMSNSTEFTSNSLAIASIVLTVLDDLQIPIHRRLLRVFSDDHSQDHGDLDAGFPIWVHIRDRRFLLEEKPKPNLTVAWDGSGDFKTIKEAVESIPKRS... | 125 |
A0A9R0JD86 | 2.4.1.18 | ACT_SITE 476; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 531; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1" | MVYTISGIRLPSTVPSIHNKTSCFHGDIRRNSSFSLFLNNKSSASLSRKIYAKKSSYDSDSPSATLADSQKILVPSGEAEGSLSDESLTSDPNLNVPEGFHDFDVQTMKEGKESEADKHGSVAATRSEDKDVQNFVTRRTVPPPGNGQKIYEIDPLLKDHRTHLDYRYSMYRKLREEINKYEGGLEEFSRGYEKMGFNRSAEGITYREWAPGAKAASLVGDFNNWNSNADVMTRNEFGVWEIFLPNNADGSPAIPHGSRVKIHMETPSGIKDSIPAWIKFSVQAPGEIPYNGIYYDPPEEEKYIFKHPQPKRPKSLRIYE... | 73 |
Q658G7 | 2.7.11.1 | ACT_SITE 778; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MAAARAPWLWWWVVVVVGVAVAEAASGGGGGGDGEGKALMGVKAGFGNAANALVDWDGGADHCAWRGVTCDNASFAVLALNLSNLNLGGEISPAIGELKNLQFVDLKGNKLTGQIPDEIGDCISLKYLDLSGNLLYGDIPFSISKLKQLEELILKNNQLTGPIPSTLSQIPNLKTLDLAQNQLTGDIPRLIYWNEVLQYLGLRGNSLTGTLSPDMCQLTGLWYFDVRGNNLTGTIPESIGNCTSFEILDISYNQISGEIPYNIGFLQVATLSLQGNRLTGKIPDVIGLMQALAVLDLSENELVGPIPSILGNLSYTGKLY... | 99 |
Q9LYN8 | 2.7.11.1 | ACT_SITE 1043; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAFLTALFLFLFFSFSSSAIVDLSSETTSLISFKRSLENPSLLSSWNVSSSASHCDWVGVTCLLGRVNSLSLPSLSLRGQIPKEISSLKNLRELCLAGNQFSGKIPPEIWNLKHLQTLDLSGNSLTGLLPRLLSELPQLLYLDLSDNHFSGSLPPSFFISLPALSSLDVSNNSLSGEIPPEIGKLSNLSNLYMGLNSFSGQIPSEIGNISLLKNFAAPSCFFNGPLPKEISKLKHLAKLDLSYNPLKCSIPKSFGELHNLSILNLVSAELIGLIPPELGNCKSLKSLMLSFNSLSGPLPLELSEIPLLTFSAERNQLSGS... | 99 |
Q09451 | 3.1.3.2 | ACT_SITE 35; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 315; /note="Proton donor"; /evidence="ECO:0000250" | MMISIFSLLASTAILVFANGQSNVKLEFVQAMWRHGERASQVDQYPIYEKDWIYGGGGLGELTAIGMGEMNELGWLIRKRYVTKLKFLTPKYASREVYFRSTNFNRTIISAQSLLYGLFPPSLYDVKNVDYPYSPLTWFPGFTFVPVHVDGPDQCAASQNCPCTRYDLLQGQMLTLPEVLPKYTQVVLLNRRVGGYYNMTSGLDSFTTYPDTWKCQRAYFNRTMYAKLPWYNEELYYQAQVTYAPVKGFLEGNFENPAVTSSGLDVGLEIKKVRSGVIINEVFNRANEKLNCAELGQNCTSYLNKLKFYGYSIHDNNVYG... | 145 |
F6SI53 | 1.3.5.1 | ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611281-1" | FQLENYGMPFSRTNEGTIYQRAFGGQSLDYGKGGQAHRCCCVADRTGHSLLHTLYGRSLAYNTDYFIEYFAMDLLMEEGECRGVIAMSLEDGTIHRIKAKNTVLATGGYGRAYFSCTSAHTCTGDGSAMVTRAGLPNQDMEFVQFHPTGIYGAGCLITEGCRGEGGYLVNSEGERFMERYAPTAKDLASRDVVSRSMTIEIREGRGCGPNKDHVYLQLHHLPPQQLATRLPGISETAQIFAGVDVTREPIPVLPTVHYNMGGVPTNFKGQVIYYDDKSSSDVVVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACA... | 28 |
A0A2R6XKI4 | 3.4.21.92 | ACT_SITE 131; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 156; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MRYGCSKLFSSVSSLLHRQVPLPVCEIPVGSRSYGLVPMVIEHTSRGERAYDIFSRLLKERIVSIHGPISDDTASLVVAQLLYLESEHPEKPIHLYINSPGGVVTAGLAIYDTMQYIRSPVSTLCVGQAASMASLLLAAGAVGERRSLPNARVMIHQPSGGASGQASDIAIQAREILDMRMRLNKLYVRHTGKDIEAIEQSMERDHFMSPEEAKGFGLIDEVIERRPVSLIADIVGGTVKA | 179 |
Q8VSC3 | 2.3.2.27 | ACT_SITE 337; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01398, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:29144452" | MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALPALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASA... | 66 |
B3SC97 | 3.1.4.11 | ACT_SITE 295; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 342; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MTVIKTNFKVDSDGFFVSWTENKEGMCLDMFMINEAKNGTLPKDQRVRDLIEKECGPNVSEARLLTIVYGYSLVDMKEIRLIASDAKSREIWKGGINKIIHDVISMNAPSDHFIKRSWVKLCCTGDADGNIQVKNIYKLVPSKLEDRVVDSLKALNLPNKKNAVIDPSKFPFSTFMSLYNKLCPRKDIEDIVMNRTGGKAPYLSIEQLRTFHNEEQRDPRLNELLYPFMKALQSKAIIDQYEPLEVLKGRGLITPEGLQYYFYSADSLIVPLEKLQLKAKDMDEPIAHYFINSSHNTYLVGKQFGGKSVVDMYRNVLLAG... | 153 |
A7T196 | 2.3.2.26 | ACT_SITE 728; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MVPESKYRFHNRHCLAKKGLQIYLFGHYLQPRFTKVKWEWQDPQVVGETLTFLLQIRHNYTPFTVKRTDIDIEIVHDGTPIACSLDFGGPGWQEMNRVKVTFTVRKSGDYNIAVLAMGEHITGSPFAKVFLPGSVDPAKCTIIERSSILVLQQGVYSPLLVEARDVYGNLRSISNAEDLLKYKVHIKKIGGSDSIDPELFVDSENRSNNSLHIKLEDEGIFQGTVSYDGTPVNNGELTIISLNDSEWYAVEKNIDRHCYNVWYEAALLPYPLTGSNTPPSIGNGADVARKSRKVYCYISPRNVSIKEFYMRIFPHKLHAF... | 65 |
A0A2R6XHS3 | 3.1.3.16 | ACT_SITE 289; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MMAATNGFASSDLEKSEELKAAANVAFQAHRFSRAVDLYTKAIELNADNAVLYANRAFAHTRLEEYGSAIADATKSIECNPKYVKGYYRRGAAYLAMGKMKEALKDFRQVCKIVPKDPDAMKKLKECEKAVAKAKFEEAIALDSQSVATTLDYRTIEVEDSYQGARIEDKITLEFVKKMMDDFKNQKSLHKRYAYQILLQTHELLTVTPTLVDITIPPNGHFTVCGDIHGQFYDLLNIFQLNGLPSEENPYLFNGDFVDRGSFSVECIFTLFAFKCLYPTGLYLSRGNHESKSMNKIYGFDGEVKTKFNDTMSEMFTEVF... | 144 |
D8R045 | 5.1.3.3 | ACT_SITE 183; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 314; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MASDSKCVDVEAWGRKPGVYLYTLRNGGITARITNWGATIVSLCLRDPSAGEDIDIVLGFDSCDPYMDGTSPYFGCIVGRVANRIKDASFSMDGVTYTLPANNNMNTLHGGEVGYDKVLWQSQIVKESQVPAVEFTYRSSDGEQGFPGELDVSVTYALHENELRVEMRAVPASKQTPVSLAQHTYWNLAGHKSGSILDHTICISASRYTPVDDFQIPTGELAPVAGTAFDFLQEARIGSRIDQVEGGYDHNYVLDQKQGPGLCFAARVRDPSSGRTMELLTDAPGLQFYTGNFLVAEAGKDGQVYRKHAGLCLETQGFPN... | 211 |
Q54P47 | 2.7.11.1 | ACT_SITE 840; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSRKENLNRSSSSNSIEFNRDRDRDSSNISNSSNINCNNSSQTPPIPQHNSLSGRSKHSSPIHSLKKKGSLVRQGIEDLFSSLSVDTHSSSNSNNNSSSNNNNNNNNHNINSSSESSTPTTPRSSFTPQVTMNSNQSSGNNSPQLSSRSSSQSTLIPSNEPTKSLAKFFLLAQQVDYVGDSSSTLLPVENLGLLSIQWKTYFTIGLNSTTTGYDVLKYISIKTNRDLKSLTLADSDGKIIDNDYILTQQRCKKFVVVEDLNIDDLKMKQLNHLQQLPPPSQQQLPPPQSHQQQLLQQQLQQRLQNQNQNQNNNSNSNSNS... | 99 |
T1EG16 | 2.3.1.286 | ACT_SITE 186; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MAEGGVDKKDSEEELHKEVVELDSKEVVKESACNNNFLQSIAAKFMGLFKSKPEDRSLVSVDLDGVVEFIRSGRCKNIISMAGAGLSTSAGIPDFRSPGSGLYDNLDEYDLPYPAAIFDLSYFKKNPEPFFVLAKNLLPTELIPTPCHHFLKLLHDKGLLMRHYTQNIDTLERLAGLPNEVLVEAHGTFNSGHCLKCRSKYDFDWMKNKIMSDTVPKCMKSGCKGVVKPDVVLFGENLPMKFFSLLIQDFSKCDLLIVLGTSLNVQPFASLVHKVPKKSPRLYVNLQKTSGSSFASWLIGGGSGFKFDDPDNERDVFWKG... | 58 |
A0A061ENE1 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKAGYSIFVLFVSLALFGIVEVCNARGAHGFSNLSYNYYRRTCPRAEKIVRGIIRERARINPALGAKLIRMQFHDCFVRGCDASVLLDTVNGSFPSEKKAVPNLSLSGFDVIDDIKTALEKACPKVVSCADILALAARDAVSAPFGRRLWDVPLGRRDGRISLASEINGNIPGPSANFSSLLQTFNKKGLDVNDLVILSGAHTIGVSHCGAFSRRLYNFTGKGDADPSLDRTYAIFLRKQCPNPASQTITVEMDPGSSLKFDTHYYDVLLQNKGLFQSDAALLTDGHSRGLVTTLRRKRSFFPAFATSMMKMGAIEVLTG... | 14 |
Q6AX23 | 1.8.3.2 | ACT_SITE 67; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 70; /note="Nucleophile"; /evidence="ECO:0000250" | MAAFVGLPLRSVPMLLLLLLLVVAGTARGETLYGPEDSVTILNKESVARAVFNSSSAWLLEFYSSWCGHCINYAPTWKALARDVRDWEPAIKIGVLDCAEEDNYGACKDFGVTLYPTFRFFKAFTKEFTQGENYKAVGDREIQTVRQVIIDFLQTSPAESKPQAWPSLEPISSSEISSLLTPKQSHYTAIIFESEESYEGREVILDLIQYSNIVVRRALPSDKPILEKLGIGSVPSCYLIQPNGLHGLINDVKSIRSQLSLHLKALSNVRKLLPSETAHSGLSKGVQQEDTTMNQFDRSKLYMTDLESGLHYILRAELAN... | 38 |
E3KE05 | 3.1.1.5 | ACT_SITE 1339; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 1457; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161" | MVYIILQWFSGFISFQINFQKVLILIALLAFISSWTYKLKVLNKYSFLPKTPQLTKTFKNQDASRDLNPNLLLNSKQLFSNHDHFNNYLDEFLSAIRVFGFLEKPVFHELARHLQTRRLLAGDTLSLDEDKSFYIVVDGSVQVFAQTSDRARPGQNPGSPAGDAYNDRLAYDNEDDNGFQLLNVVESGGTLSSLFTILSLLTEGVKLRYEEDEGQTDQAFSPDFVDHSPQTSQGQPHHIPTVASSPSVLPPSASAVDPENNPGDWHAINPTESVPHDGRKFPDWNKDTNEDGGDTDDDGQSVETSRRSTYTSKTTTRQSL... | 131 |
Q69PI0 | 3.1.1.11 | ACT_SITE 452; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSAFGDFGPLTERRRAEKARQQRRRIMIALGTVSIIIILIVMGAAAITYSGKKSEEDEGGSKGSSKGKSKGGGGGDDEDGGGGGGKADLRAVSKSIKMMCAQTDFADSCATSIGKAANASVSSPKDIIRTAVDVIGGAVDQAFDRADLIMSNDPRVKAAVADCKELFDDAKDDLNCTLKGIDGKDGLKQGFQLRVWLSAVIANMETCIDGFPDGEFRDKVKESFNNGREFTSNALALIEKASSFLSALKGSQRRLLAGEEDNGGGAADPHLALAEDGIPEWVPDGDRRVLKGGGFKNNLTPNVIVAKDGSGKFKTINEA... | 125 |
Q9ZU91 | 3.2.1.39 | ACT_SITE 116; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 263; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MAALLLLFLFLFASSALSQDSLIGVNIGTEVTNMPSPTQVVALLKSQNINRVRLYDADRSMLLAFAHTGVQVIISVPNDQLLGISQSNATAANWVTRNVAAYYPATNITTIAVGSEVLTSLTNAASVLVSALKYIQAALVTANLDRQIKVSTPHSSTIILDSFPPSQAFFNKTWDPVIVPLLKFLQSTGSPLLLNVYPYFDYVQSNGVIPLDYALFQPLQANKEAVDANTLLHYTNVFDAIVDAAYFAMSYLNFTNIPIVVTESGWPSKGGPSEHDATVENANTYNSNLIQHVINKTGTPKHPGTAVTTYIYELYNEDTR... | 167 |
A0A9L0QYC6 | 2.7.10.1 | ACT_SITE 824; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MLSLSASSTQDYCHISVPAQRKEKAYMEVVFSTMIFETITNQDLPVIKCVLINHKNNDSSVGISSSYPTVSESPEDLGCALRPESTEAVYKAATVEVATSASITLQVLVNTPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEAANYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCVSESIPEPIVEWVFCDSQSDSCKGESPAVVRKEESVLHELFGTDIRCCARNELGRECTKLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELEHRALEEGSYFEMSTYSTN... | 97 |
Q1L8L6 | 2.3.2.31 | ACT_SITE 288; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MGSEKDSESPHSSVSGIPNPKCRGPGKKQGRISFHSLFHSKRGPRGSKANVGTPLAQQLHQQQQIQQQQLLQPPTPTNVSSDPSTADPAEPLSTSQASLGGQELLECPLCLVRQPAEQLPELQGCSHRSCLCCLRQYLRIEITESRVQLSCPECAERLAPWQVALILDDPNLMEKYEEFLLRRCLASDPDCRWCPAPDCGFAVIASGCASCPRLVCRREGCGAEFCYHCKQAWHPNQTCDSARQQRALSLRTHSNHSPSYTAEQGHTDDIKPCPRCGAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCT... | 67 |
P06278 | 3.2.1.1 | ACT_SITE 260; /note="Nucleophile"; ACT_SITE 290; /note="Proton donor" | MKQQKRLYARLLTLLFALIFLLPHSAAAAANLNGTLMQYFEWYMPNDGQHWKRLQNDSAYLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQKGTVRTKYGTKGELQSAIKSLHSRDINVYGDVVINHKGGADATEDVTAVEVDPADRNRVISGEHRIKAWTHFHFPGRGSTYSDFKWHWYHFDGTDWDESRKLNRIYKFQGKAWDWEVSNENGNYDYLMYADIDYDHPDVAAEIKRWGTWYANELQLDGFRLDAVKHIKFSFLRDWVNHVREKTGKEMFTVAEYWQNDLGALENYLNKTNFNHSVFDVPLHYQ... | 157 |
A0A7M7MY35 | 2.7.11.13 | ACT_SITE 494; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MVFLRVRVLQVDSKEIELPGSVLFDPFVAVNVKESVKDANGQTQLRQKRKTAFVEWNKCFDSHLYDGRVIQVIVYNRPESYLAEANYKVNELAAMCGMDGRIETKWLDLMPYGRLQVQLRCFPEEGGGGDPMNSVRSTVSHHNSDMDKKDDTTGLLTKRRVAIRKAKVHEHRGHKFTPHYFRTPAYCSYCNEFIWGLVGTQGYRCMECELSVHKRCFNQVLGKCPGTGVNSTETKKLKERFNINMPHRFKVNNYKSPTFCDHCGTMLYGLFRQGVKCEVCNVNVHHKCKNNVPNLCGVNQRLLSEALSSIEITKSMKDKK... | 100 |
A0A0G2KJW7 | 3.4.19.9 | ACT_SITE 133; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MGFSVLVSACACVCVCVYVSAAPLGDEAENDRPIIGILTQEVDSEVMRKFGNTYIPSSYVKYIESAGARVVPIRLNQSFAEHEKLFKSINGLFLIGGAVNLETSDFARTAGFYFRLALKANDQGDYFPIWGTCLGFQLLTVLVAGENLLSKTTAENVTYPLNFSSEALSSRMFSSFPSELRRALSEEPLTANFHHYGVTKEAFMNNEKLTGLFSVISTNIAQNGAEFVSTIEGRKYPFYGVQWHPEVNRFQWNPHYSFPHSSNAVHVSSLLAQFFVNEGRRSTHRFSDAAEESAVLIYNCNPVYVEKISAYEQSYFF | 176 |
Q9HVQ3 | 4.1.1.17 | ACT_SITE 335; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MSIKVEDYFAPETFQRMKAFADKQETPFVVIDKQTIADAYDQLTDCFPFARIYYAVKANPATEITELLRDKGSNFDIASIYELDKVMKTGVGPERISYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGCQTDMAMDLLILARQLGLEPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIVLKMINMGGGFPANYITKTNDLETYAEEIIRFLKEDFGDDLPEIILEPGRSLIANAGILVSEVVLVARKSRTAVERWVYADVGKFSGLIETMDESIKFPIWTE... | 195 |
Q8INB9 | 2.7.11.1 | ACT_SITE 389; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNYLPFVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKFSWQQSWPSRTSAAPTHDSGTMSINTTFDLSSPSVTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKS... | 99 |
A0A8J1LDZ9 | 2.7.10.1 | ACT_SITE 800; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MARGSLLLLPLLLLLLSPLTRALEETLMDSTTATAELGWTVRPTSGWEEVSGYDENMNTIRTYQVCNVFEVNQNNWLRTKYIRRRGAHRIHVEMKFSVRDCSSIPNVPGSCKETFNLYYYESDFDSATKTFPSWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSKSGFYLAFQDYGGCMSLIAVRVYYRKCPRIIQNGAIFQETLSGAESTSLVAARGNCIPNAEEVDVPIKLYCNGDGEWLVPIGRCLCKAGYESVENGTVCRACPSGMFKANQGDDSCLHCPINSRTTSEGATNCVCRTGYYRSDSDP... | 97 |
A0A8V0YTP2 | 2.7.11.1 | ACT_SITE 1931; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR629601-1" | MSQKSWIENTFTKRECVYIIPSSKDPHRCLPGCQICQQLVRCCCGRLVRQHACFTASLAMKYSDVKLGENCNQEIEEWSVEKHTEQTSTDAYGVINFQGGSHSYRAKYVRLSYDTKPEAILQLMLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWIITGGVNTGVAKHVGDALREHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVKLRRELEKTINLQRIHARIGQGVPVVALVFEGGPNVILTVLDFLHESPPVPVVVCEGTGR... | 99 |
Q2QM77 | 2.7.11.1 | ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVAAVRAPVKPEMVELSPAAMERYSSDADTTAPNSSLSSAASSTGSLARCSSLSRLSFDCSPSAAVAAAATSCSPPRASVLLRPHRSGDVAWAAIRAASTTSAAPLGPRDFKLVRRIGGGDIGTVYLCRLRSSPERESPCMYAMKVVDRRAVARKQKLGRAAAEKRILRQLDHPFLPTLFADFDATPHFSCAVMEFCPGGDLHSLRHRMPSRRFPLPSARFYAAEVLLAIEYLHMMGIVYRDLKPENVLIRADGHIMLTDFDLSLQSTTSPSLDGDTDTDDEASGGASCFPDHLLRFKRRRNAVAAPRPRFVAEPVDARS... | 99 |
Q4WN54 | 2.3.1.225 | ACT_SITE 153; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250" | MCYYISILIYWGADCRTVGTGPVLMYCTKTIRSYFRCRHPFFSSINSSQIFFLSLLIAGECMFIPSAWPRVSTFHRLFIPALALLPYVFLYASVVTKSYITHENHEDEMARYPYDRVIFNPGHRCRTCDFLKPARSKHCSFCKACVSRHDHHCVWLTNCVGRNNYHYFLSLLLSLSLMLAYGSWLGFSLVSQTLEGLIPSSSPLRSKSQDWTTWLNVWAIAIASDIRVGAVAMLTAMTAPLAMAFLLYHTYLIWAGMTTNESAKWSDWKEDVADGLVFKSTRSEIYGNQSHSDEDTPAQRTWPVSSNQILVITDGEPPKE... | 57 |
A0A8M2BEG2 | 2.1.1.37 | ACT_SITE 1275; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFESQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFEARDGQEIVPVDDVMKSPKALKSSYESGRAGEESDMEINGGRRSATYDPKWQRNLKWIRASDMGDNYAYCTTCDYNIILLAGFHDLKRHQLTQNHMKHETGRTNLPGRKQIEESISCSETMLLFIQSHCLSSLPSRINRVSQRTARCILGLKYPNDIVSACKLNPYCIYIYGQVPLDVKTGDKTNCHVVLA... | 47 |
Q8CIR4 | 2.7.11.1 | ACT_SITE 1929; /note="Proton acceptor"; /evidence="ECO:0000250" | MQVKKSWIEGVFYKRECNKFIPSSKDPHRCTPGCQICHNLVRCYCGRLIEEHHGLDRAWNLSVTEGHGDEQWSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIRTSWDTKSDHLLHLMLKEWNMELPKLVISVHGGLQNFKISSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDALKAHSSKSLRKIWTVGIPPWGVIENQRELVGKDVVCMYQTLGNPLSKLTTLNCMHSHFILCDDGTVGMYGNEEKLRRNLEKHLSMQKIHTCSRQGVPVVGLVMEGGPNVILWVWETVKNKEPVVVCEGTGRAADLLAFT... | 99 |
Q9ZV85 | 3.4.19.9 | ACT_SITE 166; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"; ACT_SITE 279; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607" | MWRFCFFLSLLFFDVSAVKSAESIFLPSQIGVEDSRVFESLSLSPVCSAADPNLNYKPVIGILTHPGEGRWDARLHSLKNYAYATNISYIAASYVKLAETGGARVIPLIYNEPEEILFQKLELVNGVIFTGGWAKTGLYYDVVEKIFNKVMEKNDAGEHFPVYAMCLGFEILSMIISQNRDILERFNSVNYASSLQFFKNVNIEATVFQRFPPELLKKLSADCLVMQNHYFGISPDNFQGNPYLSSFFNIVTTSADKDSKTFVSTIRSKRYPVTAFQWHPEKNAFEWGSSEIPHSEDAIQVTQHAANYLVSEARKSMNRP... | 176 |
D8RPL5 | 1.11.1.24 | ACT_SITE 45; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MGLNLGDIVPDFKAESTMGTIKFHEYINGSWAILLSHPSDFTPVCTSELGSLASRIHEFDRRGVKVIALSCNDVNSHREWLGDIESYCPETKVKYPIVADPSRDLAVRFGMLDPVEKDAAGMPLTCRACFVIGPDKRVRLSILYPASTGRNFSELVRVIDSLQLTDKFSVATPANWENGRKCMILPTISDEKAKEMFPKGFDTVKVPSGKAYIRLVEQPTL | 12 |
P50527 | 2.7.11.1 | ACT_SITE 505; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MERGTLQPRKKAPNGYGITPIVAHKTGEPVRYEVEDDLRKLKPSRTAPKPPAINTNLAEDTFSGFPLSQSRTTVSRVSLGSRQHSSSSIRKLQTNVSDVRSYDERNQKKSAFENFVSSMSSFLTGGGSSPTSSYGSGSASPRKSTVISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLEEGAKPPFPRESTEKPLLSVSALSSSSHLQPTSATSSSSRLYPSRPAPTPPASSSSSPLLSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQTLSTSETKHI... | 99 |
A0A0K9NSC3 | 3.1.1.11 | ACT_SITE 371; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAKNFITFATLFLLFLTLHVYGGDSIGTFTKFTSCSQLPHPKACYSLTQNADPLYAGGKVKSGFREFNIQGAMSGFRRVHVEVAAVDVAKFDSRTRGAWDDCVALGEETIEHLRNSVENPSSEETQTWLSAAAANQQTCADGFFDLGLIPPPSMANLLSSNITDLLSNSLAVNVPEPTISGRNRKLFSVGGGDGNDDLFPEWLSDDDSRRLLRSVSVKANLVVAKDGSGNYKTIKEALSHVSGKRRGNRRFVIYIKAGVYKENVEVKKSMKNLMFVGDGIDRTIITGKRSVKDGWTTFRSATFAVAGKGFIAKGMTFQNT... | 125 |
A0A9R0JPA0 | 1.11.1.7 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAQNSKIIFFSAFILLSVAVFGSQAALDNHYYDQTCPQAEYIISQTVLNASIYDPKVPARLLRMFFHDCFIRGCDASILLDSTPGNKAEKDGPPNISVRAFYVIDDAKAKLEKACPHTVSCADVIAMAARDVVTMTGGPYWKVLKGRKDGRLSKASDTTNLPPPFLNADQLIQTFANRGLGIKELVALSGAHTLGFSHCASFVARVHNFSTIHETDPSMNAEFASMLKKKCSRSNNNGDAGQFLDSTASRFDNDYYRQIIAGKGVFGTDQVMYNDQRTRSMIEAFAKDQNLFFREFAASMIKLGNVGVNEVGEVRLNCR... | 14 |
G7J5X8 | 4.1.1.17 | ACT_SITE 369; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MPTLVTEESQSQITNLKPIFCASGVKGNKVTTLSSEVTISDFIQSIIKTKPTENDSPFSVLDLRVIIDLMNKWTTELPTVKPFYAVKCNPNISLIGTLASLGSNFDCASRAEIESVLSLGVSPDKIIYANPCKSESHIKYAASVGVNVTTFDCAGEVEKIKKWHPKCELLLRIKPEEDSGARSCLGLKYGALHNEVPELLKAADMAGLKVTGVSFHIGSGGADAKAYHGAILLAKEVFETASRLGMPKMKILDIGGGFTSGSKFDEAAFNVNDAIKTHFGNDEDLVVIGEPGRYFAETAFTLATKVIGKRVRGEMREYWI... | 195 |
P44309 | 2.7.1.21 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124" | MAKLYFYYSTMNAGKSTTLLQSSYNYRERDMNTLVYTAAIDDRFGVGKVTSRIGISQDAFLFRSETNLFDEINEHLKKEKVHCVLVDEAQFLSKQQVYQLSDVVDKLKIPVLCYGLRTDFQAELFEGSKYLLAWADQLEELKTICYCGRKANFVLRLNDQGEVIKEGAQIQIGGNDSYLSVCRLHYKEKCGQI | 88 |
A2FPH6 | 2.3.1.48 | ACT_SITE 268; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MDLTKGDIVSAFCEELQTYLKGEVVTSRQTAKGQQVYVHFFKQDKRLDKWYDIDQLEKTDLDSEELKESKLNSYSQFGAAYEDFEKLHDQVTKIRNIDLVTIGKYTIKTWYYSPYPDEFNQLDHIFVCDKCFRYFKTQEELDSHMQGERPYPPGKEIYRNENISIFELKGNSQKLSCQCLCLLSKLFLDHKTLYYDVEGFNLYVLCELGDDDQVHIAGYFSKELDSSDNNILACITILPPYQKKGYGFLLISLAYEIARREGKVGGPERPLSDLGKIAFSSYWREVIISTLKDKLTEIKYISDIVKLTYIDEDDVVDTLK... | 61 |
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