Datasets:
mrlom
/
ec-active

Dataset card Data Studio Files
xet
Community
1
Entry
stringlengths
6
10
EC number
stringclasses
260 values
Active site
stringlengths
0
544
Sequence
stringlengths
20
2.05k
labels
int16
1
260
Q4WP34
2.5.1.18
ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006386-1"
MAAPKITLYFDVVSPFAHIAFHVLKHSPTFAKCDITYVPIFLGGLLKACGSTPPIQIKNKAQWINQERRRWARYFSVPIVEKTPPGFPALTVAPQRALCAISKKAPERFVPAVEALFQSYWVEGNGQIGQPEGFGPVLEKVLGKDSTEQILKAMSQYEAKSLLLANTDRAFKSGAFGLPWFECTNPKGETEGFWGIDHLGQVAEFLGLDRSLDKGFRAVL
77
A0A3B6QE31
1.11.1.7
ACT_SITE 81; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAAAVPLPLPVMLLVAVAVMLVGAGAGAAGVRGGRQRQQQLRMGFYDKSCPAAERIVGDYVRLHVRRVPTVAPALLRTHYHDCFVRGCDGSILLNSTAAGAAEKDAPPNLTLRGFDLIDRVKGLVEEACPGVVSCADVLALAARDAVAAIGGPSWRVPTGRRDGTVSTMQEAVRELPSPSMTFPQLVALFAGKGLDVRDLVWLSGAHTIGIAHCSSFADRLYSYPSAGNGTGTVPPLDAAYAANLRQRKCRMGGRDAAVEMDPGSFLTFDLGYYHTVLKHRALFRSDAALVTDAAARADIAGVVSSPPEVFFQVFARSMARLGAVEVKTGSQGEIRKHCAVVNS
14
Q24145
2.7.10.2
ACT_SITE 789; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028"
MSRDSDPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDPDYQNLPELVQTVHI
98
A0A1S3Y125
1.11.1.7
ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAALLCKRNAKSLIFSSIICFLIQITALNGQLRVGFYSQRCHNAESIVSSVVKEASQGEPRMPAMLLRLHFHDCFVQGCDGSILIDNVKEAERNAFGHEGLGGFEEIEKAKTRLEAQCPGVVSCADIVALAARDAIVLLHIYILRYVDDSIDVLKGKFKNKGFTEKELVILSGAHTIGTTACFFMPRRLYNFTGRSDADPTINSKFLPELRSKCPKNGNINFRIPLDNASERKFDDQILHNIKNGFAVIASDARLYDDKITRAVIDSYLQRKKSIPNSPSFARDFGLTMIKLGRLDVKTGLVGEIRKVCNSFNKM
14
Q8EHN5
3.1.1.29
ACT_SITE 22; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083"
MSEIKLIVGLANPGAEYVQTRHNAGAWYVEELARICGVSLVADSKYFGLTARAVLHGKDVRLLIPTTYMNLSGKAVGALANFFRITPEEILVAHDELDMPPGVAKFKLGGGHGGHNGLKDIIAKLANDKNFYRLRIGIGHPGDKNKVSGYVLGKAPAKEQELINAAVDEAVRSTEILFKEDMVKAMTRLHSFKAE
127
F4KGQ0
4.1.2.13
ACT_SITE 217; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P00883"; ACT_SITE 259; /note="Schiff-base intermediate with dihydroxyacetone-P"; /evidence="ECO:0000250|UniProtKB:P00883"
MSCFKSKFAGKSYFRRTFHSSIIQFHPQLSILIWHRRYSIIRTYELIANAAYIGTPGKGILAADESTGTIGKRFVSINVENVESNRRALRELLFTTPGALQYISGIILFEETLYQKTASGKLFVDVMKEAGVLPGIKVDKGTVELAGTNGETTTTGLDGLGDRCKKYYEAGARFAKWRAVLKIGNNEPSELAIHENAYGLARYAVICQENGLVPIVEPEILVDGSHDIEKCAYVTERVLAACYKALSDHHVILEGTLLKPNMVTPGSDSGSKVKPEVIAKHTVRALQRTVPAAVPAVVFLSGGQSEEEATVNLNAINQLKGKKPWSLTFSYGRALQQSTLKAWGGKEENVDKAQKAFLARAKANSEATLGGYKGDAQLGEGASESLHVKDYKY
197
A0A1D6F267
1.11.1.7
ACT_SITE 113; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAKVAALTITLLGLLVSVTCQGSIYSAQQQQDASSSSSSPGCILRGWIPFLHPCRDGQPPTPNPLPPPSGAGLTVGYYKNCPGAEGIVRKAVEKAMDNGNRGIGAGLIRIFFHDCFVRGCDASVLLRNTSGSSDQTEMFGLPNINSLRGFQVINDAKAELEKACPRTVSCADIVAFAARDATRNLSYGAIDFQMPAGRLDGRVSLKEEAEKNLPGPFDSLDDLQKSFAAQGLGFNDMVTLSGAHSIGVARCRFFTNRLPPNPSDMDRDLARSLKATCDQNGLDSKVVQDPVTPVALDNQYYKNVHNGKVLFTSDAALNSTDDARKVVDGFANNAVDWYRAFADAMVKMGNIRDRTINRPKPEIREKCFIYNTY
14
A0A2K1J295
2.3.2.26
ACT_SITE 1209; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MVLSVLALSIWGLFRCMRQITSVQSSRVHNRPSTASSSLNMEVISLREDDRVERTQREIHAALLHNPVMAERSHTVRERELTLERGLEIQDREAHFMSSARAQALVSPVGLRSTSSKRKLDDYEIGVAESSVSATSQVRARRETREDVQEGSVTESSGRERFEIGLLVGAAEAQPLDGESQMREEDGNAALDDDSTWEDEPNWNLSSSEEIGESSKEPPDKIEDSSRAEEDRRLEEVSEDHGSTLQVVLGGPTMVVDSGSNPYEFTLTSDPTNRSSTGVSLSSLGVNDVGRVEVEAGHSGSNEGRTDDLASSDVQIEGETADDEFSAKELERDGIIDCQEELISGNHRNSSTLMTRPGDFIASSISSISNLTVGTSAGRMNDERLVRIDGCSSSPMELSPARLQFFVRTYGRTIVLHAHASDLVESVHQQIFAKTGLPVSEQRLIFGRLQLQHDQTLESCQFYNDATLTLVARMRSTALPASWQLINDLVATIRHMCDVGDQQLGLKLMHSQDCVRASVQEFLKMAVKSVPVSEHMQVFELAGATSALVMLLLSPVESNRECAEDAITLFLSSNDEYLPASIHRHCAPVLLDFCKLLNKSAPNHNLYASCRQTLARLLETVGVAHGSPYFNEAKAEKIVEDFAPFVNELSARLTQNLRCTAKAYASKESPVSFSSYVKEAKDFTAFVIPLCKAIEVCKGIDTSGSGSIAKESAVVLAECPCNTDNAVVSEGLLSAYDFTRNIAAEVGAEIGSHGWLRQLFKDLLLEVDSCLEAVGLVAERQNESYGPDSIVSEDRPFGLAPFLVVLKGLHAIAKLYEGAMADLMEMLLVRRVSLNILIRQSRWQQDEDFWLLEHKSLLDFESKRRLVMAMLPEPQDDHDERQEVVVKRATLLTESFEQLAYVEPEVLQGGISVEFATEEATGPGVLREWFSMICREIFNPQNALFLACPNDRRRFFPNPASGVNPGHLTYFRFCGRVIALALMHRVQMDVVFALSFFKQLAGLPVLWEDAKDADPTLYESCKKILELDADLIDTDILGLTFVSEVEELGSHKSMELCLGGKDMVVTSENRRHFVELLVQRRLVSSVAEQVKSFSQGFSDLLLNSTTHQQFIRALTPEDLDLMLYGKDRNICLEDWKAHTEYHDYSATDDYIIWFWQIVEKMAPDQRRRLLFFSTSVVHLPAEGFAGLSSKFHIHRAHTDISWLPTAHTCFYQLVLPAYPTYEIMCARLLAITERHVAEGFGFA
65
O84874
2.4.1.18
ACT_SITE 399; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"; ACT_SITE 452; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"
MDPFFLNTQHVELLVSGKQSSPQDLLGIVSESLNQDRIVLFRPGAETVFVELRGKIQQAESHHSGIFSLPVMKGISPQDYRVYHQNGLLAHDPYAFPLLWGEIDSFLFHEGTHQRIYERMGAIPCEIDGVPGVRFIVWAPHAQRVSVIGDFNGWHGLVNPLHKVSDQGVWELFVPGLTAGACYKWEMVTESGQVLIKSDPYGKFFGPPPWSVSVVIDDSYEWTDSEWLEERIKKTEGPMNIYEVHVGSWRWQEGQPLNYKELADQLALYCKQMHYTHVELLPVTEHPLNESWGYQTTGYYAPTSRYGSFEDLQYFIDTMHQHGIGVILDWVPGHFPIDSFAMSGFDGTPLYEYTRNPSPLHPHWHTYTFDYAKPEVCNFLLGSVLFWIDKMHVDGIRVDAVSSMLYLDYGRYAGEWVPNRYGGRENLDAIRFLQQFNTVIHEKYPGVLTFAEESTTFPKITVSVEEGGLGFDYKWNMGWMHDTLHYFEKDFPYRPYHQSDLTFPQWYAFSERFLLPFSHDEVVHGKRSLIGKMPGDAWRQFAQLRLLLGYQICQPGKKLLFMGGEFGQGREWSPGRELDWELLDISYHQGVHLCSQELNALYVQSPQLWQADHLPSSFRWVDFSDVRNGVVAYLRFADADAKKALLCVHHFGVGYFPHYLLPILPLESCDLLMNTDDTRFGGSGKGFREPEILTPEIARQEREAAGLIEADDESGPDCWGLDIELPPSATLIFSVTLQ
73
Q8WML3
2.3.1.48
ACT_SITE 599; /note="Proton donor/acceptor"; /evidence="ECO:0000250|UniProtKB:Q9H7Z6"
MVKLANPLYTEWILEAIQKIKKQKQRPSEERICHAVSTSHGLDKKTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKSTKESRGSCNDLRNVDWNKLLRRAIEGLEEPNGSSLKNIEKYLRSQSDLTSTTNNPAFQQRLRLGAKRAVNNGRLLKDGPQYRVNYGSLDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICSFCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTTNVKALRWQCIECKTCSACRVQGRNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQIKRRYAKPIGRPKNKLKQRLLSVTSDEGSMNAFTGRGSPDTEIKINIKQESADVNVIGNKDVVTEEDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKLYLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQHQRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYHHHERHISIKAISRATGMCPHDIATTLQHLHMIDKRDGGFVIIRREKLILSHMEKLKTCSRANELDPDSLRWTPILISNAAVSEEEREAEKEAERLMEQASCWEKEEQEVLSTRANSRQSPAKVQSKNKYLHSPESRPVTGERGQLLELSKESSEEEEEEEEDEEEEDEEEEEEEEEDEEEEEEEEEEEEEEEEENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSRNLKEGSKDNPEPLKCKQAWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPLEPDEQVTVEEQKETSEGKTSPTPISIEEEAKEAGEALLPQEENRRQETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEGEEEEEEGGNVEKDPDGAKSQEKEEPEISPEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEELPRESFKEVLENEEAFLDLNVQPSHSNPEVLMDCGVDLTASCNSEPKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQAVQSLTQESSEQDDTFQDCAETQEACRSLQNYTRADQSPQIATTLDDCQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQSAISVPSLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSICGNGSSQNSCSYSNLTSSSLTQSSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQGCVVERPPSSSQQLAQCSMAANFTPPMQLAEIPETGNANIGLYERMGQSDFGAGHYPQPSATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVPGGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHVSMRTKSASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMNMNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGTQPYAQQPMQTPPHGNMMYTAPGHHGYMNTGMSKQSLNGSYMRR
61
A0A6I8N5A1
2.7.10.1
ACT_SITE 668; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MGRSPGCPAPCPLLLLLLLLLLSWGRGRARDALEAVFLENPQNLTTSLGKSARLRCSIRLGGEPPEVSWLRDGHPLDLADSNQVQVPMSDDDDWMVTSELSISSLQLSDAGIYQCSVLVAGNQLLSRSAHLGLEGLPFFSEEPEDLVVGAATPFNLSCSAQGPPEPVQLLWLWDGVPLHSLLDVLARPPSTLSLSGLNKTSSFSCEAHNAKGVTTSRTATVKVLPQRPTHLRLVSSSPTELQVSWEPGPSGIYPLTHCTVQAVPSDGSGAGGSDTPRGEPHTLGTEVPPYALRLDGLQPLTAYHLRVACASAQGVSPWTHWVPVETPEGVPLGPPEHVIALRNGSLAVVRWQEPRRPIPGLLRGYKLAYRGQDDPEVLVDVGLSRELTLQLREPLQNLTVRVAAYTGAGDGPWSAPVPLAPHGPEDGGPVRQHVQEPPAPAFSWPWWYILLGAGAATACVLFLALFLVQRRKKETRYGEVFEPSVERGELVVRYRVRKSYSRRTTEATLNGLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGSVMEGQLNQDDRVLKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCLQGSECQEFPAPVVILPFMKHGDLHSFLLYSRLGDAPVFLPTQTLVKFMTDIASGMEYLSSKHFIHRDLAARNCMLNENMTVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPLDCLDGLYELMSSCWSLSPRDRPTFAALREELEFTLKGLPLAQDPEEILYVNMEDGGGSGAAGAGGEPEGAGGEADRKAGCSCVTAEVHAPDPAGRYVMCPAPPGDTPQPAPCAASEEGA
97
A0A9K3JCY0
3.4.21.89
ACT_SITE 129; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 179; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
MFHKIICNSTNSKIKMVSSHLLHLSSLHNPKLTFNFNNAGSKPITKTPNFASFCSPKRYNRDLVCYGSKEEVNGGGGGDGNEEKKDGLLLLPDWIDFSLDDVKTVVVAVAVSLAFRAFIAEPRFIPSLSMYPTFDVGDRIVAEKVSYYFRKPCPNDIVIFKSPPVLQKAGYTDDDVFIKRIVAKAGDVVEVHNGKLIVNGVVRNEDFTYEAPKYEMNPVRVPENYVFVMGDNRNNSYDSHVWGSLPSKNIIGRSVLRYWPPARIGSTVLPGGCAIDQPENTNSSLESQQDTSKLASQ
178
A0A061GKR2
3.1.1.11
ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSISVARFVASGSKKKLFLALFASVLLVTAIVSIATTLSVSKRKSSNNNSNNAAHSIIKSSCSSTLYPELCLSTISAAPDAETKIKSPKDVIVTSMNLTITAVQSNYLSIKKLISTNKNLPKREKTALNDCLELEDETLDELYKAEQDLSDYPTFNKSISQHADELKTLLSAAMTNQETCLDGFSHDSADKKVRQALIDGQMHVFHMCSNALAMIKNLTDTDMASQGYPSGRQLEEQDETEWPEWLSAGDRRLLQAPTVTPDVTVAADGSGDFRTVSEAVAAAPERSTRRYIIKIKAGVYKENVDVPRGKTNLMFVGDGRVNTIITASRNVVDGSTTFNSATVAAVGDGFLARDITFQNTAGPSKHQAVALRVGSDLSAFYRCDMLAYQDTLYVHSLRQFYVQCLVAGTVDFIFGNAAAVFQNCDIHARRPNPGQRNMVTAQGRDDPNQNTGIVIQKCRIGATSDLLAVKGSFASYLGRPWKQYSRTVIMQSNISDIIHPAGWFEWNGPFALDTLTYREHQNTGAGAGTSNRVTWKGYKVIASVTEAQGYTAGNFIAGGSWLAATGFPFSLGL
125
E9GEM5
2.7.11.1
ACT_SITE 158; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1"
MATVAPASSSGVATPSSQMALMDCETFGRTYHVGHVLGKGGFGTVYAGNRIRDGLPVAVKHIHKSSVTTWSHVNGVRVPLEFCLLRQVAHVPGVVRLLDACDADDVFVLVMERAESSQDLFDFITERGALPEQAARNFFRQVVEAVVQCHRAGVIHRDIKDENILVDLKTHCLKLIDFGSGDYLKDGVYTEFDGTRVYSPPEWIRHRRYHGRPATVWSLGILLYDMVCGDIPFEQDDQIVRATVNFVTRSPGRLRLSPQCEDLILRCLEYRPADRPSLEHILAHPCSNDDVMRYIKTARVHLYPSLIGINFRQHC
99
A0A067F997
4.1.1.17
ACT_SITE 354; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MGGQRVTTVVTKEELTEFVRSTILKRQEFDEVPFYILDLGVVVTLYNQMISKLPMIHPHYAVKCNPEPALLEALAALGSNFDCASRSEIEAVLALGVSPDRIIYANPCKPVSHIKYAANVGVNLTTFDSVEELHKIRKWHPKCDLLIRIKPPDDSGAKHPLDSKYGVDHHPQEIVPLLEAAEASGLSVVGVAFHIGSAATKFAAYRGAIAAAKAVFETAARLGNNKMRVLDIGGGFSFTNSNTKSFQEAASIIKEALHAYFPNELLPGSSLRVISEPGRFFTYSAFTLYTQIIGKRVHGEMRNYWINDGKYGSFDWVNYDEAIAKCTPLTLASSLTTSKGLSRTYNSKVFGPTCDAADEVFSGHKLPELEVTDWLVFSEMGAYTRARGTNFNGYNTAAIPTYVVRSNRT
195
A0A1U8AWU0
1.11.1.7
ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MASLRLLSVFLCQLLVLLFLFDPSSAQGLKVGFYKDTCPRAEEIVRRTTAQYVTHLPSLAAPLLRLHFHDCFVRGCDGSVLLNATSANPNPEKTAIPNQSLDGFFVVDVAKSRLEKECPGVVSCADILALVARDAVKLVNGPFWDVPTGRRDGTVSLALESLANLPPPFFNITSLKLSFLSKGLSVKDLVVLSGGHTIGQSHCPSFTNRLYNFTGKGDSDPSLDSNYVPRLKSACQPGDTTTQVEMDPGSYRTFDASYYKLVAKRRGLFQSDSALLNDAETKAYVFEAAGSGSTFFKDFGVSMVNMGNIGVLTGTAGEIRKHCAFVN
14
Q9LW83
2.7.11.1
ACT_SITE 652; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MWSNCIFLTLFTFYLFLGQSCCQTDTLLQGQYLKDGQELVSAFNIFKLKFFNFENSSNWYLGIWYNNFYLSGAVWIANRNNPVLGRSGSLTVDSLGRLRILRGASSLLELSSTETTGNTTLKLLDSGNLQLQEMDSDGSMKRTLWQSFDYPTDTLLPGMKLGFNVKTGKRWELTSWLGDTLPASGSFVFGMDDNITNRLTILWLGNVYWASGLWFKGGFSLEKLNTNGFIFSFVSTESEHYFMYSGDENYGGPLFPRIRIDQQGSLQKINLDGVKKHVHCSPSVFGEELEYGCYQQNFRNCVPARYKEVTGSWDCSPFGFGYTYTRKTYDLSYCSRFGYTFRETVSPSAENGFVFNEIGRRLSSYDCYVKCLQNCSCVAYASTNGDGTGCEIWNTDPTNENSASHHPRTIYIRIKGSKLAATWLVVVASLFLIIPVTWLIIYLVLRKFKIKGTNFVSESLKMISSQSCSLTNKRLSTLRVGSTIDQEMLLLELGIERRRRGKRSARNNNNELQIFSFESVAFATDYFSDANKLGEGGFGPVYKGRLIDGEEVAIKRLSLASGQGLVEFKNEAMLIAKLQHTNLVKLLGCCVEKDEKMLIYEYMPNKSLDYFLFDPLRKIVLDWKLRFRIMEGIIQGLLYLHKYSRLKVIHRDIKAGNILLDEDMNPKISDFGMARIFGAQESKANTKRVAGTFGYMSPEYFREGLFSAKSDVFSFGVLMLEIICGRKNNSFHHDSEGPLNLIVHVWNLFKENRVREVIDPSLGDSAVENPQVLRCVQVALLCVQQNADDRPSMLDVVSMIYGDGNNALSLPKEPAFYDGPPRSSPEMEVEPPEMENVSANRVTITVMEAR
99
W5MBJ6
3.1.3.1
ACT_SITE 123; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1"
CSGTFHNMIHRMEQSMVLGLLAAFLLTGVLSATPMQEKDPAYWNTQAKETLQAALKMKPISHRAKNIILFLGDGMGVSTVSATRILKGQMEGNSGEETVLTMDTFPHLALSKTYSVDMQVADSASTGTAYLCGVKANAKTVGVSAAAVAYKCNSTFGNEVYSVLHRAKAQGKSVGIVTTTRVQHASPAASYAHSVSRSWYSDADLSSSALRDGCKDLATQLVFNTDIDVILGGGRMYMTPKGTPDPEYPTSSSRRGKRKDGKNLIELWLEARKSKNAQYVWHKEQFDAVDVNSTNCLMGLFEAKDMRFELYRNSTRDPSIIEMTEKAIQILSKNPKGFFLFVEDKGRIDHGHHDGIAKLALTEAVMFDRAIQRASQLTRDSDTLTVVTADHSHVFTFGGNTPRGNPIFGLVPEMAEDDLPYTSILYANGPGYLLENGTRANITYVDYLDEEYMQQAAVPLDSETHGGEDVAIFAQGPMAHLFHGVKEQNYIAHVLAYAACLEPYTDCPPEPNSGSGSHGSVSLLLAVSILPGFLRT
141
Q9VLR2
3.5.4.5
ACT_SITE 80; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MTHLTKNFARPEKNEEVVTFGSLDPSVQELLTAAFQVRQRAYVPYSGFKVGAAFRAKVDGKIFTGCNVENAAFTPGSCAERTAIAKAVSEGATEFLAGAVLAYEPNVFTTPCGVCRQFIREFANADIPIYVAQAIDARIAEKQELLQSDDPVMCTSIFNLLPSSFHTYRK
187
Q55CY9
2.7.11.1
ACT_SITE 1158; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MINKILIKLITIIIFCFSFLFAEEDLIRTPPGYYNLTRHKRYPHITEYQSSQDTDLYYPDVCRNALRNDIIPGVDEFFPFLFPGFNSDGPNSIYIQKNSSLLFKSESLGTTYNFVAVCVEGSFTVKGSMFFTINSLIILPGGRFESEAGIEFYDENDPLHIYNNPDFPKDPFGFFPGILVLGGTISVVAKESLVYRADRISNSSIEISPPFSPMNKINQTIRIFTELYPLGFYCSFSSDLERKILSLLDCLPISENDKIIRVLIEVDRDQNVSPTNILKKGKTTKGSIYITGDSNVYFKNMFFKNLGFTTNEPYNDTKLIFSPNDPNQVTDIIMGTNQRFRSSLYIEFSKNVTIDGCAFFEDNLTRSPLVLFDSNVIISNSLISSKSGSNIIAQYGTESIQSSNNSYILVKIDTASLDVDQNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNMDYGNQGNGIYSISPNINSNGDSFFGQQYAFNYYFISKNSVNSNQDNSSLLNSKPIELIIIDSSFNPTNSNGSLNKYLLNINSDGNKTISTYLVCNSIIEYYSGWLMDNLNSNQQISFEGNLFQNGCNKVDGNCTISQNSKYSTDLPKVANQTKFDEIVQLDKLFSNGITSINPNEKVIISTKINSKIHYYQIQLFFTHLPIDDQPTPLSIYIENQPVFLLEPIKSTFPTFNNFTFKFENKNSLDKINIAFTTRGDIYLTSMATYSSIVVEPPTETPTETPTETPTETPTDTPTQTPTQTPILTSKPITQISVDRNENLELKIALPICLSLALLIGIIIMICIFKKVQSNSKLKKDDDENEMATIKEGNKSIIVSQPPTVIEEKPQDNSKPDDQKLIERDQQINNPILKIREYPSLKDIELSNEETKSPQYGSLNSFSTLQFSRQYDYGSEEFPFQFNKQVLEFNLNGRKCMNDEVINDSLMIHNKSEITYLVNIIFPQNIETGCVSILNVEIFNESFELLPHCTTEVKFSLTLTCTTKFLENFAVLVEAQGSKCHTFLSVHVESETSLKLDYKEIKTEQLIASYLPSKVYVFKGYYRDLAVAVKKFAISDNSKSFEKIKNEVQILSKVNNINVVRYIGSAQNISHVCIVTEYAKEGSLGSLIHDSKIKLSFIQKVKFMLDAAKGFTFLHASEIVHGDIKPDNLLVFSKEISGVCVKICDFGNSEELGEKESKSKPDSTMNYLPNEVFDGEGYQKSADVYAFGVSLYEVMVEKIPFHEICYNDIPNRVQDGFRPTADLDTIDDDIRKIIECCWIKEKSKRPSFSEISLHLEIKFSKLLHQMNESEESTSNHNTNSKTKEDKDLDEN
99
Q8RGM4
2.7.1.23
ACT_SITE 52; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361"
MIKLSIIYNEDKEDAIKIYKELLKYLKSKKEFEVLDDKNISQAEYIVVIGGDGTLLRGFKKIKDKKVKIIAINSGTLGYLTEIRKDGYKKIFENILKGKINIEERYFFTVKIGKKKYNALNEVFLTKDNIKRNIVSSEIYVDDKFLGKFKGDGVIIATPTGSTAYSLSAGGPIVTPELKLFLITPIAPHNLNTRPIILSGDVKIVLTLVGPSEFGIVNVDGHTHNKINIEDKVEISYSKESLKIVLPDDRNYYNVLREKLKWGENLC
89
Q9Y6R4
2.7.11.25
ACT_SITE 1463; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSNAKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRSNELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQLVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQLPQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVLKSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRARDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGYNFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPAFISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTRSMPSDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE
105
Q944Q0
2.7.11.1
ACT_SITE 176; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q9JIH7"
MASGSGFLGQISSMEEADFAEKDPSGRYIRYDDVLGRGAFKTVYKAFDEVDGIEVAWNLVSIEDVMQMPGQLERLYSEVHLLKALKHENIIKLFYSWVDEKNKTINMITELFTSGSLRVYRKKHRKVDPKAIKNWARQILKGLNYLHSQNPPVIHRDLKCDNIFVNGNTGEVKIGDLGLATVLQQPTARSVIGTPEFMAPELYEEEYNELVDIYSFGMCMLEMVTCEYPYNECRNQAQIYKKVTSNIKPQSLGKVDDPQVRQFIEKCLLPASSRPTALELSKDPFLARDGGKDSALLASSSTSSKYVRPPQLEHLPMDVDHNENKSVSSNEDYPWSQTIELQRIAENKEFRLRGERSDDVTASMVLRIADPSGKCRIVHFAFYLESDTATAIAEEMVEELHLTSQEVVVIADMIDDFIMQLLSDRTSSHHNQNSPRLTHEDHEAANQQTVNSKDEEAAGQSMKSDISADYYFPYSANDGNAAMEAGRDAESMSSYLDSCSMMSTIYNLSISDNDYPEDLKTELNLIESQFNQSFQDLLKLKEDAIENAKRKWITKKQKAVNIS
99
A0A2K1YEP9
3.1.1.11
ACT_SITE 395; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MEKANTATMATMNTPLLATPKTSRRKTICLVLSMVAILSSTTLVTMRYYTKTDPSSPPGLLQNLCDHAYDQESCLAMVSQIASNTSTKMSQVGLLQLLLGKSTPHIQNTIEKAKVIHSRINDAREQAALGDCVELMEISKYRIKDTIVALERVTSKSHANALTWLSSVLTNHDTCLDGLNGPARSTMEPDLNDLILRARTSLAILAAISPSKENNDIFSLKEDFPSWLPSMDRKLLVALPKDINADVTVAKDGSGKYKTVKEAVASAPDNGKTRYVIYVKKGTYKENVEVGKKKKNVMLVGDGMDSTIITGSLNVVDGSTTFNSATVAAVGDGFIAQDIWFQNTAGPEKHQAVALRVGADQSVINRCRIDAYQDTLYTHSLRQFYRDSYITGTVDFIFGNAAVVLQNCKLVPRKPMSGQKNMVTAQGRTDPNQNTGTSIQKCDIIASSDLTPVKSSFKSFLGRPWKEYSRTVVMQSNIGDLIDPAGWSAWDGEFALKTLYYGEYLNQGAGAGTSKRVNWAGYHVITSANEAKKFTVAELIQGGVWLKSTGVSYTEGL
125
A0A067H583
3.1.1.11
ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MASKLFFVITIPILIALLPVFARPSHATDVAPTTPVSAGSVCKSTPDPSFCKSVLPNQTANVYTYGRFSIRKALWQSRKFLNLVDKYLTRRATLSTTAIRALEDCRLLAGFNMDFLLSSFETVNSTSKTLPTMQADDVQTFLSAILTNQQTCFDGLQDTASAWSVKNGLSLPLSNDTKLYSVSLALFTKAWVPKKKKATAWQPTRKQRLFRNGRLPFKMSEKTRVVYETVSRRKLLQAAPDDEVLVSDIVTVSQDGSGNFTTITDAINVAPNNTDVTNGYFLIYITAGVYEEYISISKNKKNLMIIGDGINQTVITGNRSVVDGWTTFNSATFAVVAPKFVAVNITIRNTAGAIKHQAVALRNGADLSTFYSCSFEAYQDTLYTHSLRQFYRECDIYGTVDFIFGNAAVVLQNCNIYPRLPMSGQFNAITAQGRTDPNQNTGTSIHNCTIRASSDLASGSQTVQTYLGRPWKEYSRTVYMQSFMDSSINPAGWQIWSGDFALSTLYYAEYNNTGPGSNTANRVTWPGYHVTINATDAANFTVSNFLLGDDWIPQTGVSYTGALI
125
Q54IP4
2.7.11.1
ACT_SITE 298; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNDKISKLESSILQLTEEVKQLESKQASKELEIRTLVDNAINSQNPAQERELINKLFTESLIDLKLKAEKIQTLERYRQEIITNLLVEQKQPNDTSIISAWEQLKISSFRINPNNNNNNSNNTNSSDSNQNYSSVILNGSLTEDSTSTISPDSTKNRDEEEIIRWEIDRNEISYNREAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPHLLLFMGACTAPEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRAILIARDTVLGMTWLHASNILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDSKDKLLGQAGSPLYMAPEMLVNQPYDGKVDVFSFSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRLKDLLARCWDHYPSRRPSFAEISKQRILETILIDGLILDSSARQFWSQYYMGKEEVPWNSFIVNFSLYCGFESNLSADDIKIKFLKLLLVPVDSDMVTIDNFGKILTWVGPLTNGREFFDKVYSICSIKGFMAATSSKNASQYLAGKKTGTYILRFSSDPGSYAISYLNKNKEIIHARVIYKQGSGYIHHGGQTHYATLDDLIKNTFKSLGIKEPFEGGPFHALTVAASSSKPFNIAGAYIPVAPSKKI
99
I1JWX6
5.1.3.3
ACT_SITE 188; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 320; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MFKVYLVSSFLLGLLLLAQAHGNDKKIGFYQLKRGDLHLNLTNYGASLISVIVPDKHGNLDDITLGYDDIEQYKNDSWYFGATIGRVANRIGHAQFTLDGHTYKLPANDHGNTLHGGFKGFSDVVWTVKSHKEDDHITFTYDSHDNEQGFPGRLEVSVTYMLIGTNKYSLKMIARPIDKATPVNLAHHTYWNLKGQNSGDNILSHEVQIFGSKITPVDKELIPTGKFESVKGTPYDFLEPREVGSRINDLPGLYDMNYVLDASSPYHFRKVIIVREKVSGRKLELWSNQLGLQFYTGGMLNATKGKDGAIYHKHGGMALETQGFPDAVNRPNFPSQIVRPGETYKHYMVYRFTAS
211
Q5JI50
5.4.99.25
ACT_SITE 213; /note="Nucleophile"; /evidence="ECO:0000256|HAMAP-Rule:MF_01893"
MIVEKASEVLERYQLCDHCLGRLFAKLGKGTNEERGKAIRFVLNMERAKDGLPPVEEPKECELCNNVFDRIPELVENMKEAAKDVEFETFLVGSRFPDEVKEKEKAIWDEFGIETAEPINREFNRELGKAFGRATGKDTSKSPDVVFIVEPYSGKIELQINPLYIYGRYRKLLRGIPQTPHPDFEESVASIICRPFSRATGGKCVFKGAGREDVDVRMLGNGRPFILEIKRPKRRNINLEEIAREINASGKVEVLNLRFTTPDEAERVLSTPHRKEYLALVLVKEGVTPEEAEEVAKKLTGLEIHQRTPWRVRKARADKVRVRRVHYAEARWIDDKHFELRLITDGGLYIKELISGDKGRTKPSVSDLLGKPAWCERLDVLNVLDEERSEDSS
218
Q818G0
3.5.4.5
ACT_SITE 55; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1"
MNSKQLILEAIEARKQAYVPYSKFQVGAALLTRGGKVYRGCNVENASYGLCNCAERTALFKAVSEGDKEFVAIAVVADTKRPVPPCGACRQVMVELCKQDTKVYLSNLHGDVQETTVGELLPGAFLAEDLHE
187
F4P5T8
1.1.1.205
ACT_SITE 351; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"; ACT_SITE 449; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156, ECO:0000256|PIRSR:PIRSR000130-1"
MASDNSVNKRQALDPVVKDVKKSKTEIDINQPTIDGLSAKELFDVRISGGLTYNDFLILPGYIDFPASAVSLETRITRRFTLKTPFMSSPMDTVTETNMAIHMALNGGLGVIHHNCPIEEQCDMVRKVKKFENGFITDPKCLSPSHNVQDVLDIKRKFGFCGIPITADGKMGSLLLGIVTSRDIDFLQSDNDQQKLLKDIMTTDLVTANQGISLVEANRILSESRKGKLLIVDANGHLTALLARSDLIKTRDHPLASKRDSRQLLCAAAISTHNEDKIRLAALVAVGLDIVVLDSSQGNSSFQIEMIKYIKKTHPQIDVIAGNVVTTEQARNLILAGADALRIGMGSGSICITQEVMACGRPQGTAVYRVAQYARQFGIPVIADGGISNVGHIIKAISLGASAVMMGSLLAGTTESPGEYFYNDGQRLKKYRGMGSLDAMDKGDAAGKRYFSEKDKVKVAQGVAGAVVDKGSVKKFVEYLYAGLQHGLQDIGVKSIKVLQEHVSQDIIRFERRSPSAQLEGGVHGLHSFEKRLFQ
3
H2MAB6
2.1.1.320
ACT_SITE 451; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR015894-1"; ACT_SITE 460; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR015894-1"
MAPVSLSLRKKSLLNQSTEVMASASTGSRVSCGRDMNCVPEIAATLAAVAKLGFDFLCMPLFHPRFAREFELEPAKSRPGAQTRSDLLLCGRDWGTLIVGKLSPWICADSEIETERRNSEEALTQELNFSAYLGLPVFMIPLTGPHNANLARLLLSHIHTGHHTSNFWIRVPLMAAEDTREDLIENEPFSCPDETSVDEKTWNWWNTFRTLCDYNKRICLAIDIGADMPSDAVIDKWMGEPIKAAILPTSLFLTNKKGFPVLSKAHQRVIFRLFKLEAQFIFTGTSRHTEKDFRSYLQYLEYLNQNRPAPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAVYKCLLDRVPEEQKDTNVQVLMVLGAGRGPLVNASLRAASQADRKLKVYAVEKNPNAVITLENWRFEEWGDRVTVVSSDMREWEAPEKADIIVSELLGSFGDNELSPECLDGAQHFLKDDGVSIPCSYTSFLAPLSSSKLYNEVRGCRERDKSPECHFETPYVVRLHNFHELADPKPCFTFTHPKKDMNNNRYQCLRFSVGCNSVLHGFAGYFETTLYKDVTLSIKPETHSPGMFSWFPILFPLKQPISIARDDEIAVRFWRCNNGKKVWYEWAVTEPTCSAIHNPAGRSYTIGL
44
A8J537
1.11.1.6
ACT_SITE 65; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 138; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MDPAKIRPSSAYNTPYWTTNSGAPVWNNNNSMTVGTRGPILLEDYHLVEKLAQFDRERIPERVVHARGAAAKGFFEVTHDISALTAADFLRAPGVQTPVIVRFSTVVHERGSPETLRDPRGFAVKFYTREGNFDMVGNNMPVFFIRDGMKFPDMVHAFKPNPKSHIQEAWRIMDFLSHHPESCHMLTFLLDDAGIPLNYRHMPGFGVHTMKLINKAGRETYVKFHWVPKCGEKYLLDDEAVMVGGANHSHATKDLFDAIAAGDYPEWALMVQTMDPADEDKFDFDPLDVTKTWPESLFPMQPVGRMVLNRNVDNFFNENEQVAFCPAIIVPGIGYSDDKLLQTRIFSYADTQRHRLGPNYLLLPVNAPRAPHHNNHHEGFMNFMHRDEEINYFPSRFDPVRNAERVAAVSSAPLSGRREKMVIAKENNFMQAGARWRAFDAARQERFVVRVADMLADPRCTQEIRRIWVGYWSQADPQLGARIAAKLQGRGCL
13
G0HV10
6.3.4.2
ACT_SITE 391; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000255|HAMAP-Rule:MF_01227"; ACT_SITE 517; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605"; ACT_SITE 519; /evidence="ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000255|PROSITE-ProRule:PRU00605"
MPTEPETDYDPELGRKFIFVTGGVMSGLGKGITAASTGRLLKNAGFDVTAVKIDPYLNVDAGTMNPFQHGEVYVLKDGGEVDLDLGNYERFLDIDMTFDHNVTTGKTYQHVIEKERSGDYLGRTVQIIPHITDDIKRRIREAAEGNDVCIIEVGGTVGDIEGMPYLEALRQFAHEEDEDDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDILVGRCSDKLDIDTKEKIALFCDVPTEAVFSNPDVDDIYHVPLMVEEEGLDQYVMEELDIATEALPEDERENRWRDLVTQNTEGEVDIALVGKYDLEDAYMSVHEALKHAGLEKNVDVNVQWVNSEKMNDHHADRMREADAIVVPGGFGARGTEGKIEAIRYARENDIPFLGLCLGFQMAVVEYARNVLDLDDAHSAELDEDTPHPVIDILPEQYEIEDMGGTMRLGAHETEIDANTLAATLYGGESCTERHRHRYEVNPEYIDDLEAAGLKFSGYAENRMEILELAPEDHPYFIGTQFHPEFRSRPTRASPPFVGLLEAVLGDDPHTVTTEEVSH
252
A0A078ITL9
3.1.1.11
ACT_SITE 394; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSKLSCITLCQKKVILFATTSSHYSLEEEKKMYNPSRKTSKHINLNLLALTFHLIFIISTVHSQSTQRLTEPNSITELIVATLNQTILNVNVSYTSFFNLQKRLGPNIAHRYRCAFEDCLGLLDDTISNLETAIFKLQTSSVGTHDVNMLLSDAMTNQDTCLEGFTTSGIHENNNDNTYKLTDILKDSILKISSNLSDSLGMLQKIPRHKHSKEAYEVDVEFPSWVLENDKRRLHAPVKEIKFNLMVAQDGTGNFTTINAAVSAAPNSSATRFVIYIKRGVYFENVEIPNKKTMIMFVGDGTGRTVIKANRYSTPHGRTTYQTATVGVKGEGFIAKDISFVNFAGPFKGQAVAFRSGSNHSAFYRCSFEGYQDTLYVHSAEQFYRECDIYGTIDFVFGNAAVVFQNCSLYARKPNPGQKIVYTAQSRTCPNQSTGISMINCRFLAAPDLIPVKGSFEAYLGRPWKNFSRTIIMKSFIDDLVVPAGWLEWNGNFALETLHYGEYMNEGPGSNITNRVKWPGYRPILNETEATQFTVGPFIDGGRWLNSTGIPFNTGL
125
Q6P3R8
2.7.11.1
ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCKIQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDYYYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLKVEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHNDMKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARSWLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEAMDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGGAPQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM
99
O76039
2.7.11.22
ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVSSVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL
102
Q9JZP5
1.8.1.4
ACT_SITE 456; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2"
MSQYDVVVIGAGPGGYVAAIRAAQLGFKTACVDAGVNKAGNAPALGGTCLNVGCIPSKALLQSSEHFHAAQHEFAEHGITVGDVKFDAAKMIERKDAIVTKLTGGVKFLFQKNKVTSLFGTASFAGKNGDAYQIEVDNKGEKTVIEAKHVIVATGSVPRPLPQVAIDNVNVLDNEGALNLTEVPAKLGVIGSGVIGLEMGSVWNRVGAEVTILEAAPTFLAAADQQIAKEAFKYFTKEQGLSIELGVKIGDIKSEGKGVSVAYETAAGEAKTEVFDKLIVAIGRIPNTKGLNAEAVGLEKDERGFIKVDGECRTNLPNVWAIGDVVRGPMLAHKASDEGVAVAERIAGQKPHIDFNNVPFVIYTDPEIAWVGKTEEQLKAEGVEYKKGTSGFGANGRALAMGKAKGTVKVLADAKTDRILGVHMIGPVVSELVTEGVTALEFFASSEDIARIIHAHPTLSEVVHEAALAADKRALHG
36
Q9C660
2.7.11.1
ACT_SITE 554; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MTTPAQAPREEVSLSPSLASPPLMALPPPQPSFPGDNATSPTREPTNGNPPETTNTPAQSSPPPETPLSSPPPEPSPPSPSLTGPPPTTIPVSPPPEPSPPPPLPTEAPPPANPVSSPPPESSPPPPPPTEAPPTTPITSPSPPTNPPPPPESPPSLPAPDPPSNPLPPPKLVPPSHSPPRHLPSPPASEIPPPPRHLPSPPASERPSTPPSDSEHPSPPPPGHPKRREQPPPPGSKRPTPSPPSPSDSKRPVHPSPPSPPEETLPPPKPSPDPLPSNSSSPPTLLPPSSVVSPPSPPRKSVSGPDNPSPNNPTPVTDNSSSSGISIAAVVGVSIGVALVLLTLIGVVVCCLKKRKKRLSTIGGGYVMPTPMESSSPRSDSALLKTQSSAPLVGNRSSNRTYLSQSEPGGFGQSRELFSYEELVIATNGFSDENLLGEGGFGRVYKGVLPDERVVAVKQLKIGGGQGDREFKAEVDTISRVHHRNLLSMVGYCISENRRLLIYDYVPNNNLYFHLHAAGTPGLDWATRVKIAAGAARGLAYLHEDCHPRIIHRDIKSSNILLENNFHALVSDFGLAKLALDCNTHITTRVMGTFGYMAPEYASSGKLTEKSDVFSFGVVLLELITGRKPVDASQPLGDESLVEWARPLLSNATETEEFTALADPKLGRNYVGVEMFRMIEAAAACIRHSATKRPRMSQIVRAFDSLAEEDLTNGMRLGESEIINSAQQSAEIRLFRRMAFGSQNYSTDSLTRNSYISKDENL
99
Q8Y9X7
3.2.2.27
ACT_SITE 61; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00148"
MVKTWEEFLKQEAKQPYFIELMEAVKDARAKGNVYPSEEDMFSCFRLCPYNQVKVVILGQDPYHGPGQAHGLSFSVQKDVRIPPSLRNIYKELKTDLDIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTDHVLEELNNYDKPLVFILWGNHAIKAASGITNPQHLIIKGVHPSPLAASRGFFGSKPFSKTNAFLEEHERKPIDWDLNEQ
173
D6WSZ3
2.7.11.1
ACT_SITE 741; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000660-1"
MSSEESTESRQNNELEALQAIYGDDLRDLRGKSAWNAWTPLNLSISLNPQQGSSGLHEVYVKLDLHVTCPETYPNTVPVIKLENSKGLSDNSLIQLQKILEEKADKLRGEEMIFQLAQHVQEFLHLHNKPASKSFYDEMLQRQKEKEEKDLQAKLMEEDRERQFVQQEVQKRQEILKLESRMRRYNSENSDDSDQRRRSISYNSNENSDESLCSHKKTVIVEFTNREIKRGQCLKHCSYNHVVFIGMDVKTGEIVLLSEWIITNRKYLSSLEQEFNYLAKLKHQNLAHYLSFKYEGHADGAVVHILKEYVSGPNCSFFMNENLSVSIQFIKYVAKGVLTALDYLHRNNVVHKDIRESCVYISEKGIVALTNYSLHRRLTDISSQTNITSNYSKKTDIYKFGVFLISLLQGASLTEDDDVDIPPCVPSDLYDFLSRCLEKQEKERFTAVQLLNHSFLRQNSLLSSPGHKIDHNIPDGNISPDLATDELNPLQHQSGQSRIEKEFEIIDNLGKGAYGDVIKARNNLDGRYYAIKRIKLNPRNRQLNKKIVREVKLLSRLNHENIVRYYNSWIERTVIKGDDSSDMESTTSGIDDKCPRIVRPDEFTLNDNIEELAPSIKNVEVSVTFDSISQPAYDSSSDESSCDDENSLDIYEESDSDGIEFEKDSHAPSPSDPPSTKSPQLLETGRQIEFMYIQMEFCEKSTLRNAIDNSVYLDEDRVWRLFREIVEGLAHIHQQGMIHRDLKPVNIFLDSNDHVKIGDFGLATNMTPKLNEHDLNRTFPERYDMDESKTGLVGTALYVAPELNVASKANYNQKVDIYSLGIIFFEMCYKPLLTNMERIKILTSLRKKEIVLPEDFAPGNPKQKFLVTWLLNHDVAKRPTSVELLQSEHIPPPVLEECELRELVRHTLSNPQLKGYKYLIASCFDQTLTPAQNITYDKDSAVPTLNKPQIYDFVKETIVKIFKQHGAQNLTTPLLMPKSHYYEGVESCVKLMTHFGGIVSLPHDLRVPFARYVAWNRITLLRRYSVERVYREKRVFGFLPRELYECAFDIVTPSPGNHTSDAEVLYVIYEIINELPGVKNKHVTIRLNHSLLMKAILLHCGVKNRHEEILQKFSDVKDGKVPKSDLQDYLIQFGLSDNAISTLTNIFSSEFEVSKAANHFQSITRKKSSEASHLAKQALQELKSIAYNAEAFGVTFEMVVAPGAVYNIQQYSGMICQFVCELKKKHKHGNKEVLAAGGRYDAMITSYRKIMENANMLARDIKQSAVGVSLSLDKLAQAVMREQEDLPSLEVLDVAVCSVGTKPLLREKTKILRNLWSAGIRCAMIEATNIEEIQEQCGELKVPHVVMLKDSEQGTVRVRSWERDRFQEKTVKTPELVETMQRIIKCWKEGAQEVLPITGTVFRSDSKSSYDKNEHEATVAVLFVTEDKLSANARRRYDIQIRSHLDVLVKKLSGFVTVLGLSVESNVIRTIASYLEWETDQQFHKSVQAIIEKHQRHKKYLTDVCDEIYEQKSKKTKPAVILFSLLDSFYRLLI
99
Q9Z2P5
2.7.11.1
ACT_SITE 143; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSSVKLWLNGASSISLVGSEELENLGFVGKGGFGAVFRARHTAWNLDVAVKIVNSKKISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGSLSGLLQPSCPRPWPLLCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDPELHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREAEVVDKTSLIRGAVCNRQRRPPLTELPPDSPETPGLEGLKELMTHCWSSEPKDRPSFQDCESKTNNVYILVQDKVDAAVSKVKHYLSQYRSSDTKLSARESSQKGTEVDCPRETIVYEMLDRLHLEEPSGSVPERLTSLTERRGKEASFGHATPAGTSSDTLAGTPQIPHTLPSRGTTPRPAFTETPGPDPQRNQGDGRNSNPWYTWNAPNPMTGLQSIVLNNCSEVQIGQHNCMSVQPRTAFPKKEPAQFGRGRGW
99
A0A2R6WPU5
1.11.1.7
ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MTLFRRDCQALSVLLGLWLCTLARATSVGDISPQWVKGSLSIKFYEQTCPQLDGIVKAAVTQALNTDLTLAGSLVRMAFHDCFVRGCDASLLLDSTPAQQAEKTAGPNQNSLRGFNVYDAIKNAVETVCPGVVSCADIIALVARDSVVATGGPTWPIYLGRRDGIVSSQQEANSQIPAATLGYSQLMAAFANVGLSQHDLVTLSGAHTLGRAQCFLFSNRLYNFTGQGDTDPTIDATFAAQLKAACPPNSPTASFVPLDSTQNIFDRNYYTDVLAGRGVFQSDAALLTARYPLSIITAISQDPTNFFKDFPVSMNRMLAIGVLTGTQGEIRKKCNVVNS
14
P32944
2.7.11.1
ACT_SITE 579; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MSSLDEDEEDFEMLDTENLQFMGKKMFGKQAGEDESDDFAIGGSTPTNKLKFYPYSNNKLTRSTGTLNLSLSNTALSEANSKFLGKIEEEEEEEEEGKDEESVDSRIKRWSPFHENESVTTPITKRSAEKTNSPISLKQWNQRWFPKNDARTENTSSSSSYSVAKPNQSAFTSSGLVSKMSMDTSLYPAKLRIPETPVKKSPLVEGRDHKHVHLSSSKNASSSLSVSPLNFVEDNNLQEDLLFSDSPSSKALPSIHVPTIDSSPLSEAKYHAHDRHNNQTNILSPTNSLVTNSSPQTLHSNKFKKIKRARNSVILKNRELTNSLQQFKDDLYGTDENFPPPIIISSHHSTRKNPQPYQFRGRYDNDTDEEISTPTRRKSIIGATSQTHRESRPLSLSSAIVTNTTSAETHSISSTDSSPLNSKRRLISSNKLSANPDSHLFEKFTNVHSIGKGQFSTVYQVTFAQTNKKYAIKAIKPNKYNSLKRILLEIKILNEVTNQITMDQEGKEYIIDYISSWKFQNSYYIMTELCENGNLDGFLQEQVIAKKKRLEDWRIWKIIVELSLALRFIHDSCHIVHLDLKPANVMITFEGNLKLGDFGMATHLPLEDKSFENEGDREYIAPEIISDCTYDYKADIFSLGLMIVEIAANVVLPDNGNAWHKLRSGDLSDAGRLSSTDIHSESLFSDITKVDTNDLFDFERDNISGNSNNAGTSTVHNNSNINNPNMNNGNDNNNVNTAATKNRLILHKSSKIPAWVPKFLIDGESLERIVRWMIEPNYERRPTANQILQTEECLYVEMTRNAGAIIQEDDFGPKPKFFI
99
O94737
2.7.11.24
ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MDSKHSVFNVMGQEFVLQKGYEVIKGLGKGSYGVVCSAKNIEVEDNNKVAIKKITNIFSKKMLAKRALREIMLLQHFRNHKNITTLYDMDIVDPSKFNELYLYEELMQANLNSIIRSDQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPSNLLINADCKLKICDFGLSRGISVNQGQGTEYMTEYVTTRWYRAPEVMLSFQSYSKAIDLWSVGCILAELLGRKPFFKGSNYVDQLNQIFCILGTPNENIISKIKSASAQSYIRSLPTLPKMPYSKIFPYANPDALDLLNCLLTFDPYDRISCEEALEHPYLIIWHDPNKEPVCSEQFDFGFEAIDSIEEIRQMIINEVSRFKGLTGNQKLYHSISNT
104
A0A7M7SV91
2.3.1.48
ACT_SITE 518; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MGRRKKEDSDSSERWESDSSVDVEEVSTSDEDQGNRRITRQSTRIVTRATNQVMRMRGQSPMKTGKGVDRKTSDSSDSEPTVPPTDTAAEKTNNKKGRKRGKSETHHSDTESGASLNGGGPKKKIQKKSTGKGDAKLTNGELSSDKESGDGDKKRRSRIIAEQQLLKSENVELRCPVPGCDSRGHFTGKFTKHRTLWGCPLYHNMTAEECQAKADARAEKRRNRHQEQENDEKKALRQTNSSRAQQQKRYQVQELRRQRKELTEDVKVKSRQHREEFHKSREPLLNGITSQFDLDLFREAQMRASEEMVRVHAQSLPKHDSPLTANREKCGLGNPGEGTVKKLEFGRFELNTWYSSPYPEEYARLPKLYICEFCLKYMRSSTILRRHLAKCIWRHPPGDEIYRKGINSVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYIMTENDSSGCHILGYFSKPHYYVLQEKNSFLNYNVSCILTLPQYMRQGYGKMLIDFSYLLSKREEKIGSPEKPLSDLGLISYRSYWKGVLLKYLHKLDAKEISIKDISQETAINPYDIVSTLQSMSMLKYWKGKHLVLKRQDLIDEYLSKEKERTNGLKLIDLNSLKWTPPICEPV
61
A0A061DQB9
1.11.1.7
ACT_SITE 99; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKGKKKGRKKKTNYQVEQAHRQATIGCYRLKDIRMKSHILILLCIVVLGVIGSCQGDGIGKNYYKVTCPHAEEIVKNVTEKHVCKNPSLPAKLLRMHFHDCFVRGCDASLLLNSTTNNTAEKQAIPNLTLSGFDVIDDIKAEVEKTCPGVVSCADVLALAARDSVSFELQRPLWEVLTGRRDGRVSRISEALANIPSPFSNFTTLVRNFASKGLDVHDLVVLSGGHTIGIGHCNLFSNRLYNFTGRGDQDPSLNPAYASFLKTKCRSLRDIITTVEMDPRSSLNFDNHYYVILKQKMGLFQSDAALLTDDSALKTVDELLDSSKFFVEFAQSMQKMGAIGVLTGTAGEIRKKCYVVN
14
E9HCA8
2.7.11.13
ACT_SITE 370; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
MQLKLRPTGRLNVQVRHFREGDGPVLDGDDFSLGGGGITRRRGAIKHHKVHEVKGHKFVAKFFRQPTFCAFCRDFLWGFGKQGYQCQICQCAVHKKCHDKILGKCPGSGKESQNTIYLRERFKIDVPHRFRVHNYMSPTFCDHCGSLLYGLFRQGLKCEVCNVNCHKKCERHMPNLCGVNQKLLAEALSSVKRGSSNKSPPTSVKSESSSTSKKATKISQSTSRGTRCEPPIKTKPKFRKYGYDDFQLVKVLGKGSFGKVMLAELKGTGSYFAIKCLKKDVVLEDDDVECTMIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLNGGDLMFHIQQSGRFEQDRARFYAAEIVSGLKFLHKKGIVYRDLKLDNILLDYEGHIRIADFGMCKLQIYLDRTADTFCGTPDYMAPEIIKGLKYNQCVDWWSFGVLLYEMVVGQSPFNGCDEDELFWCICNEQAYYPRFLAKETKAVLVLLLEKDPQKRLGTPGCSAGDIIDQPFFKSINWDRLDRKDIEPPFKPKVRHILDVQYFDSAFTIEKPQLTPVDKDILASMDQTQFRGFSYTNPNTTD
100
C8VN86
1.1.1.34
ACT_SITE 103; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 236; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 312; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:P04035"; ACT_SITE 408; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10003"
MPESQIIELGTLGQIPLYSLERALQDPLRAVKLRRQIVSQHQATGNIDFTTDGSALPYEGYDYKAVLGACCENVIGYMPIPVGVAGPIKINGKMVFLPMSTTEGALVASTNRGCMAINAGGGVTALVLGDGMTRAPIVRFPSLEEAGAAKQWLGSDAGFLIIEDAFNASSRFARLQNIKATAVGSDLYIRFTASTGDAMGMNMISKGVEQALEAMQKHGFESMDVVSLSGNFCADKKPAAVNWIEGRGKTVTAQATIPEHAVRETLKTSVEALVELNVSKNLVGSAVAGALGGFNAHAANVVTAIYLATGQDPAQNVQSSNTLTVMKNVNGDLQISVFMPSIEVGTVGGGTVLGPQKAMLHMMGVQGADPEQPGRNAQELALLVAAGVLAGELSLCSALSAGSLVKSHLTHNRKKG
4
H2L8K1
1.11.1.6
ACT_SITE 75; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 148; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"
MAENRDKTTDQMKTWKENRGSRKPDVLTTGAGHPIGDKLNLQTAGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYCKAKVFEHIGKTTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTDEGNWDLTGNNTPVFFIRDALLFPSFVHTQKRNPQTHMKDPDMVWDFWSLRPECLHQVSFLFSDRGLPDGYRHMNGYGSHTFKLVNADGDRVYCKFHYKTDQGIKNLSVEEAEHLASTNPDYAIGDLFNAIANGNYPSWTFYIQVMTFEQAEKFQFNPFDLTKVWSHKEFPLIPVGRMVLNRNPVNYFAEVEQLAFDPSNMPPGIEPSPDKMLQGRLFSYPDTHRHRLGANYLQIPVNCPFRTRVANYQRDGPMCMFDNQGGAPNYYPNSFSAPETQPQFVESKFQVSPDVARYNSADEDNVTQVCTFFTKVLNEDERQRLCQNMAGSLKEAQLFIQKRMVENLKAVHPDYGNRVQTLLDKYNAQAKKSASVHVYNRPGASAIAASSKM
13
G7ZZU2
2.7.1.11
ACT_SITE 224; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186"
MDGSSSSSSSSSLELEDVTNLFEPIKLKDLPHLNHYISNLKTFPNPLDQNPYFHTPQLQHFYITNNNLVFSHSTRFAYRTAGPRNNVFFNPSDVRAAIVTCGGLCPGLNTVIRELVVGLWDLYGVRQIFGITAGYRGFYSSSTQPVQLNPNIVHHWHTKGGTFLQTSRGGFDLCKIVDAIQNQAFNQVYIIGGDGTMRGAVKIFNEIKQRKLNVAVVGIPKTVDNDVGIIDRSFGFQTAVEMAQQAISAAHVEAESAVNGIGLVKLMGRSTGHIVLHSTLSSRDVDCCLIPELDFYLEGKGGLFEFLDQRLKENGHAVLVVAEGAGQDIIPRTESHKEERDESGNPVFLDVGVWLKSELNKWWDRDHPGELFTVKYIDPTYMIRAVHANATDNLYCTLLAHSAIHGVMAGYTGFVAAPINGNYAYIPLEDVACAKNPVNTKDHNWSWVRSVTNQPDFLKS
84
A7SE05
2.3.2.23
ACT_SITE 98; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133"
MATTSSNVENFSPQIIKQVAREIHGLTNDPPEGIKVFSNDEDITDIQASIEGPTGTPYEGGIFKIKLVLGKDFPAAPPKGFFLTKIFHPNVAKNGEICVNTLKKDWKPDLGIKQVLLTVKCLLIVPNPESALNEEAGKLLLERYDDYSKRAKMFTEIHAKLSASSSNNISEGQQESLPGKKRVAVNEKMCDKKKKDKKRALKRL
64
Q8IYP2
3.4.21.4
ACT_SITE 56; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 101; /note="Charge relay system"; /evidence="ECO:0000250"; ACT_SITE 195; /note="Charge relay system"; /evidence="ECO:0000250"
MKFILLWALLNLTVALAFNPDYTVSSTPPYLVYLKSDYLPCAGVLIHPLWVITAAHCNLPKLRVILGVTIPADSNEKHLQVIGYEKMIHHPHFSVTSIDHDIMLIKLKTEAELNDYVKLANLPYQTISENTMCSVSTWSYNVCDIYKEPDSLQTVNISVISKPQCRDAYKTYNITENMLCVGIVPGRRQPCKEVSAAPAICNGMLQGILSFADGCVLRADVGIYAKIFYYIPWIENVIQNN
177
Q4V7Q6
2.7.11.1
ACT_SITE 136; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAAGWAPPRLEDFILTEKLGSGSYATVYKAYRKRNAREVVAIKCVSKKSLNKAAVENLLTEIEILKTVHHPHILELKDFQWDQDYIFLITEYCAGGDLSRFIRTRRILPERIVQVFLQQLASALKFLHEKNISHLDLKPQNILLSRLDRPHLKLADFGFAQHMSSEDAPQALRGSPLYMAPEMVCSKHYDARVDLWSVGVILYEALFGKAPFASKSFSELEEKILSHKTIELPTRPRLSPECRDLLQQLLQRDPDKRISFIEFFAHLFVDLEHMPSAETLEKATRLVVEAVEKDSAGEHSAALTLYCKALEYFIPALHYESDAKRKEAMRSKVCQYISRAEELKVLVSSSNKTLLMQGISGRELLKEMAQDKPRLFSALEVASAAVAKDEEGCACDALDLYQQSLGELLLMLSAESPGRRRELLHAEIQTLMGRAEFLKEQMKTSQWKSESLGQEVLSESVRNSCSLQ
99
A0QJI1
3.1.3.3
ACT_SITE 187; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 189; /note="Proton donor"; /evidence="ECO:0000250"
MNSPPKVSVLITVTGVDQPGVTATLFEVLSGHGVELLNVEQVVIRHRLTLGVLVCCPADVADGPALRHDVEAAIRKVGLDVSIERSDDVPIIREPSTHTIFVLGRPITAAAFGAVAREVAALGVNIDLIRGVSDYPVIGLELRVSVPPGADGALRTALNRVSSEEHVDVAVEDYTLERRAKRLIVFDVDSTLVQGEVIEMLAAKAGAEGQVAAITDAAMRGELDFAQSLQQRVATLAGLPATVIDEVAGQLELMPGARTTLRTLRRLGYACGVVSGGFRRIIEPLAEELMLDYVAANELEIVDGTLTGRVVGPIIDRAGKATALREFAQRAGVPMAQTVAVGDGANDIDMLAAAGLGIAFNAKPALREVADASLSHPYLDTVLFLLGVTRGEIEAADAIDGEVRRVEIPPE
147
H3GAG9
4.2.1.11
ACT_SITE 242; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 377; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"
MSKPSLLQRTCWCLVCAFKSDLTFLANGSGRNHHLFLSIHAREIIDSRGNPTVEVDLTLSGSAEIFRASVPSGASTGIHEAVELRDGGKRYAGKGVQQAVQNVKSVLAPKLIGADPTKQRDIDNLMREIDGTENKGKLGANAILGVSLAVAKAGAAAKGVPLYQHFADLIGNKNLVLPVPSFNVINGGSHAGNKLAFQEFMLLPTGAESFSEAMVMGCEVYHQLKSVIKKKYGQDATNVGDEGGFAPNIQSNREGVELLMTAIGRAGYDGKIGIGMDVASSEFLTKEGKYDLDFKTEGSTDLLTGEELGQLYKDLAKEFPIISIEDPFDQDDWTHYSSFTAGIGEKVQIVGDDLLCTNPKRIATALDKKACNALLLKVNQIGSVTESVDAVALAQKNGWGVMTSHRSGETEDSYIADLAVGLATGQIKTGAPCRSERLAKYNQLLRIEEALGSDAKYAGVHFRNPSKM
200
F7FU03
3.4.19.9
ACT_SITE 131; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 241; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 241; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MGSSWQRLCALGTVLLCFVRGDVPREDINERPIIGILAQSHKEDLQGLGKYYIAASYVKYLESAGARVVPIRTTLSDEEYDNLFNSINGILFPGGGVDLQTSKYSYVARLFYDKAKQAFKRGDYFAIWGTCLGFEELTVLTSGKQLLTPTNTSGIALPLNFTKAINESRMFQNFPKDLLVALATEPITSNFHKWSLSLKTFMENKKLSEFYTVLSTNTYKGIEFISTMEAKEYPIYGVQWHPEKNAFEWKKLKGLVHSPVGIRMSFYMADFFVNEARKSHHRFASKEEEEKALIYNYEPVFTGNYSSFQQCYFFD
176
A0A3Q7GG70
1.11.1.7
ACT_SITE 234; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MVGKARIFAGLFLICIVLPSLASAFVDHLPEVGQVNDNNDVPIHVSTVAHFSEKQVKEAMIRRAKAVHDLWANFGNNDKDDVAKEDAAPVTPTPVDSTPTTTPVDPTPTPVDPTPNPGPVNPVPADPTPNPVPANNVPAGYPGATQGPPVAMGYGGAPITQNPSDQQTVPEQAGAAQNHPTPEEIKEQRKHAGLQVGFYDSTCPNAEKIIKDGMNRAFGNDSSMAAPIGRLLFHDCFVNGCDASILLDKTPSGARVEKLAPTNGATIRGFELIDEIKAELEAECPGIVSCSDLLVYLSRDAFVVSGVPYYDVPGGRRDGMESLEANVIGNLPLPDNTVDKMIDLFKKKGLTEEDLVVLIGAHSIGVAHCFSFRYRVDNPVKATMVDPRLAGVMKFTCTTPMSTLAFDTTTQYKMDSVYYKQLSGKRALLESDALLNEDPRTKDFIQKFGDDENGWFIKFGKAMNKLTSIQVLTGDQGQIRKQCRFVN
14
A0A1U8II71
3.1.1.11
ACT_SITE 367; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MDKLVVILTFFLTHFFIFPLGNFVNGTTITSCTQTPYPDVCNFYMGNSLNVAANLDQTQFSFRDVAIQVTLSQAVQAHQLVSSMDSSSFDQRAKLAWNDCVELYEDTIHLLNLSKNTKNPIDSQTWLSAATANQQTCQNGFIDFNLASHLQTLPSMLGNFTKLISNSLAINKATTVTSSTSHSNFAKQVANRRLLSDGFPAWLSVADRKLLQTTGAPPKADIVVAQDGSGNFKTITEAVAAAGGGKRTVIYVKAGVYKENVDIKRAAKNIMLIGDGIDATIVTSSKNAQTTTTFRSATVGVSGDGFIARDMTFENTAGPQKHQAVALRSGSDFSVFYRCSFKGYQDTLYVYSQRQFYRDCDIYGTVDFIFGDAVAVFQSCNIYIRRPMSGQKNTVTAQGRTDQNENTGIVIHNSRVTASSDMKAVQGSFKSYLGRPWQKYSRTVFMKSSLDGLIDREGWLPWSGNFALSTLYYAEYMNTGAGADTSGRVKWGGYHVIGATEAAKFTVGNFLAGNSWIPGTGVPFDVGL
125
P34101
2.7.11.1
ACT_SITE 342; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNSNKEETTADGSVSTTEEQQQQQQPQQQEQINTTTASTTSNGENTASDNNNNSNNNNNNNTNNTNTNNNCDISMTEDNSKEEDTGIKVIGEGELWGKLISLNPTYPTIEIRQDSIILGRSKGVCNYTFTSPTVSGKHCKIYRDPTVKSRNVAFVDDTSTNGTFINNEVIGKGSKILIENGCEISVIPKKGSEKISFIYQDCFEEQKEMEQGGPQQKYDLREVLGTGNFASVRLGVEKETGNKYAIKIIDKKKMSMTSKRKDSLMDEVNVLTKVKHQNIISIKEVFETQKNLYLVLELVTGGELFDKIVSERKFQEDTCRYILKQLCDSVRYLHSNGIAHRDLKPENILLATPNSFLLKISDFGLSRAMDEGTYMKTMCGTPQYVAPEILTKGEREGYGKSVDLWSIGVITYILLCGFPPFGDPQTKDFFEKIKNGGFSFPSPYWDEISDEAKSLIKNLIKVDVEKRFTIDQALNHPWFTNHEEKTKEFYEKDKLEFPPPSTNDDHQPTPNTTSSNSQLVPESKCDQIQDNTTDNNNNNNNNNNNNNNNNNNNTTNNSNNIDNNNGNDESKSSKKRQLSEDSNINDEHEQKKVKN
99
A0A804J208
3.1.1.11
ACT_SITE 135; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MQQFLRWWWWLLLWALSCCVFSTDGAANITRVIIVDQSGQGNFTTLQSAIDSLPDGNSQWIQIYIKQGTYRRNNLASWQNTFKSGSERHLQAVAALVGGDRNSFHDCAFIGYQDTLCDYRGRHHFDKCWIEGAIDFIFGFGQSVYSRCVLNSVDGGWLTAHAKTSADSPGGFVFKYCTIRATKMTYLGRAWNQHSTVLFHKTWMPSTIRPEGWDAWHVIPNQYQMTYVEDGNIGAGSNTSGRVSWLKSLPPEQLQGFLSSIEFLGPDRWFDKQP
125
B9RR25
3.1.1.11
ACT_SITE 444; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MDTEENTNSMKSYSKIEEAAQSEEAFRRKTRKRLMIIVLSVLVLLIIVTGSSIGILASRNKSKDLSSPTYSANSNIRTLCNVTRYPESCYSSMSSAIKASSNGENPNPQTKELFLLSLKIAFDELMNLSSLPQKIISSQNYRNEINDPLLQSALRDCETLFNDAIDHIKESISSMQVGGGNTSKIIDDIRTWLSTAITDQETCIDGLKEAGKHLTLTNEVRYAMSNSTEFTSNSLAIASIVLTVLDDLQIPIHRRLLRVFSDDHSQDHGDLDAGFPIWVHIRDRRFLLEEKPKPNLTVAWDGSGDFKTIKEAVESIPKRSKSQFIIYVKEGLYLENVTIDKNYWNVMIYGDGMNRTIVSARNNKVDGVSTFFSGTFIAAGRGFIAKDMGFRNTAGPQKEQAVALRSSSDQSIFYRCSFDAYQDTLYTHSNRQFYRDCQITGTVDFIFGNAAVVFQNCTIQPRQPLPGQYNTITAQSKSDPNQNTGMSIQRCQMTPLDNLTATTYLGRPWRDYATTVIMQSYMGEFLDPLGWASWEANISTVYYAEFRNFGPGSMTGRRVRWPGVRPNITYEEAEKFAVESFIHGSQWLPQAQVTYDGTI
125
A0A9R0JD86
2.4.1.18
ACT_SITE 476; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"; ACT_SITE 531; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR000463-1"
MVYTISGIRLPSTVPSIHNKTSCFHGDIRRNSSFSLFLNNKSSASLSRKIYAKKSSYDSDSPSATLADSQKILVPSGEAEGSLSDESLTSDPNLNVPEGFHDFDVQTMKEGKESEADKHGSVAATRSEDKDVQNFVTRRTVPPPGNGQKIYEIDPLLKDHRTHLDYRYSMYRKLREEINKYEGGLEEFSRGYEKMGFNRSAEGITYREWAPGAKAASLVGDFNNWNSNADVMTRNEFGVWEIFLPNNADGSPAIPHGSRVKIHMETPSGIKDSIPAWIKFSVQAPGEIPYNGIYYDPPEEEKYIFKHPQPKRPKSLRIYESHIGMSSTEPVINTYANFRDDVLPRIKRLGYNAVQIMAIQEHSYYASFGYHVTNFFAPSSRFGTPEDLKSLIDRAHELGIVVLMDIVHSHASNNVLDGLNMFDGTDSHYFHSGARGYHWMWDSRLFNYGSWEVLRYLLSNARWWLDEYKFDGFRFDGVTSMMYTHHGLQVSFTGNYEEYFGFATDVDAVNYLMLVNDMIHGLFPEAIAIGEDVSGMPTFCLPTQDGGVGFDYRLHMAIADKWIELLQLRDEDWRMGDIIHTLTNRRWDENCISYAESHDQALVGDKTIAFWLMDKDMYDFMAVDRPSTPLIDRGIALHKMIRLITMGLGGEGYLNFMGNEFGHPEWIDFPRGDQHLPTGKVVPGNNNSYDKCRRRFDLGDANYLRYRGLQEFDQAMQHLEENYGFMTSDHQYISRKSEDDRIIVFERGNLVFVFNFHWSNSYFDYQVGCLKPGKYKIVLDSDDPLFGGFNRIDHSAEHFTFEGWYDNRPRSFLVYAPCRAAVVYALVEDEAEAAHALVEEDSEPGHALVEDDPEPAMQALPVKDETKPAEE
73
Q658G7
2.7.11.1
ACT_SITE 778; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MAAARAPWLWWWVVVVVGVAVAEAASGGGGGGDGEGKALMGVKAGFGNAANALVDWDGGADHCAWRGVTCDNASFAVLALNLSNLNLGGEISPAIGELKNLQFVDLKGNKLTGQIPDEIGDCISLKYLDLSGNLLYGDIPFSISKLKQLEELILKNNQLTGPIPSTLSQIPNLKTLDLAQNQLTGDIPRLIYWNEVLQYLGLRGNSLTGTLSPDMCQLTGLWYFDVRGNNLTGTIPESIGNCTSFEILDISYNQISGEIPYNIGFLQVATLSLQGNRLTGKIPDVIGLMQALAVLDLSENELVGPIPSILGNLSYTGKLYLHGNKLTGVIPPELGNMSKLSYLQLNDNELVGTIPAELGKLEELFELNLANNNLQGPIPANISSCTALNKFNVYGNKLNGSIPAGFQKLESLTYLNLSSNNFKGNIPSELGHIINLDTLDLSYNEFSGPVPATIGDLEHLLELNLSKNHLDGPVPAEFGNLRSVQVIDMSNNNLSGSLPEELGQLQNLDSLILNNNNLVGEIPAQLANCFSLNNLNLSYNNLSGHVPMAKNFSKFPMESFLGNPLLHVYCQDSSCGHSHGQRVNISKTAIACIILGFIILLCVLLLAIYKTNQPQPLVKGSDKPVQGPPKLVVLQMDMAIHTYEDIMRLTENLSEKYIIGYGASSTVYKCELKSGKAIAVKRLYSQYNHSLREFETELETIGSIRHRNLVSLHGFSLSPHGNLLFYDYMENGSLWDLLHGPSKKVKLNWDTRLRIAVGAAQGLAYLHHDCNPRIIHRDVKSSNILLDENFEAHLSDFGIAKCVPSAKSHASTYVLGTIGYIDPEYARTSRLNEKSDVYSFGIVLLELLTGKKAVDNESNLHQLILSKADDNTVMEAVDSEVSVTCTDMGLVRKAFQLALLCTKRHPSDRPTMHEVARVLLSLLPASAMTTPKTVDYSRLLASTTTAADMRGHDVTDIGDNSSSDEQWFVRFGEVISKHTM
99
Q9LYN8
2.7.11.1
ACT_SITE 1043; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MAFLTALFLFLFFSFSSSAIVDLSSETTSLISFKRSLENPSLLSSWNVSSSASHCDWVGVTCLLGRVNSLSLPSLSLRGQIPKEISSLKNLRELCLAGNQFSGKIPPEIWNLKHLQTLDLSGNSLTGLLPRLLSELPQLLYLDLSDNHFSGSLPPSFFISLPALSSLDVSNNSLSGEIPPEIGKLSNLSNLYMGLNSFSGQIPSEIGNISLLKNFAAPSCFFNGPLPKEISKLKHLAKLDLSYNPLKCSIPKSFGELHNLSILNLVSAELIGLIPPELGNCKSLKSLMLSFNSLSGPLPLELSEIPLLTFSAERNQLSGSLPSWMGKWKVLDSLLLANNRFSGEIPHEIEDCPMLKHLSLASNLLSGSIPRELCGSGSLEAIDLSGNLLSGTIEEVFDGCSSLGELLLTNNQINGSIPEDLWKLPLMALDLDSNNFTGEIPKSLWKSTNLMEFTASYNRLEGYLPAEIGNAASLKRLVLSDNQLTGEIPREIGKLTSLSVLNLNANMFQGKIPVELGDCTSLTTLDLGSNNLQGQIPDKITALAQLQCLVLSYNNLSGSIPSKPSAYFHQIEMPDLSFLQHHGIFDLSYNRLSGPIPEELGECLVLVEISLSNNHLSGEIPASLSRLTNLTILDLSGNALTGSIPKEMGNSLKLQGLNLANNQLNGHIPESFGLLGSLVKLNLTKNKLDGPVPASLGNLKELTHMDLSFNNLSGELSSELSTMEKLVGLYIEQNKFTGEIPSELGNLTQLEYLDVSENLLSGEIPTKICGLPNLEFLNLAKNNLRGEVPSDGVCQDPSKALLSGNKELCGRVVGSDCKIEGTKLRSAWGIAGLMLGFTIIVFVFVFSLRRWAMTKRVKQRDDPERMEESRLKGFVDQNLYFLSGSRSREPLSINIAMFEQPLLKVRLGDIVEATDHFSKKNIIGDGGFGTVYKACLPGEKTVAVKKLSEAKTQGNREFMAEMETLGKVKHPNLVSLLGYCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWSKRLKIAVGAARGLAFLHHGFIPHIIHRDIKASNILLDGDFEPKVADFGLARLISACESHVSTVIAGTFGYIPPEYGQSARATTKGDVYSFGVILLELVTGKEPTGPDFKESEGGNLVGWAIQKINQGKAVDVIDPLLVSVALKNSQLRLLQIAMLCLAETPAKRPNMLDVLKALKEI
99
Q09451
3.1.3.2
ACT_SITE 35; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 315; /note="Proton donor"; /evidence="ECO:0000250"
MMISIFSLLASTAILVFANGQSNVKLEFVQAMWRHGERASQVDQYPIYEKDWIYGGGGLGELTAIGMGEMNELGWLIRKRYVTKLKFLTPKYASREVYFRSTNFNRTIISAQSLLYGLFPPSLYDVKNVDYPYSPLTWFPGFTFVPVHVDGPDQCAASQNCPCTRYDLLQGQMLTLPEVLPKYTQVVLLNRRVGGYYNMTSGLDSFTTYPDTWKCQRAYFNRTMYAKLPWYNEELYYQAQVTYAPVKGFLEGNFENPAVTSSGLDVGLEIKKVRSGVIINEVFNRANEKLNCAELGQNCTSYLNKLKFYGYSIHDNNVYGVLVALGIPQIANTLDGWPAYAAGIFMEFHRNTSTNERFFKVLYREGDDTPISDVTSQLPICNGATLCPLGALQTLAETLKPLPDITTLCKTPL
145
F6SI53
1.3.5.1
ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611281-1"
FQLENYGMPFSRTNEGTIYQRAFGGQSLDYGKGGQAHRCCCVADRTGHSLLHTLYGRSLAYNTDYFIEYFAMDLLMEEGECRGVIAMSLEDGTIHRIKAKNTVLATGGYGRAYFSCTSAHTCTGDGSAMVTRAGLPNQDMEFVQFHPTGIYGAGCLITEGCRGEGGYLVNSEGERFMERYAPTAKDLASRDVVSRSMTIEIREGRGCGPNKDHVYLQLHHLPPQQLATRLPGISETAQIFAGVDVTREPIPVLPTVHYNMGGVPTNFKGQVIYYDDKSSSDVVVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALTIAEENKPGEDIGEISENAGEASIENLDKLRYADGATPTAELRNKMQQVMQTNAAVFRTGPVLKEGVQKIQDIYDEMDDLKLSDRGLIWNSDLIETLELQNLLLNAAQTVVAAERREESRGAHAREDFKDRCDEFDYSKPLQGQEALPQSKHWRKHTLSNMNVQTGKVELNYRPVIDSTLDQKECKTVPPAIRSY
28
A0A2R6XKI4
3.4.21.92
ACT_SITE 131; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 156; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086"
MRYGCSKLFSSVSSLLHRQVPLPVCEIPVGSRSYGLVPMVIEHTSRGERAYDIFSRLLKERIVSIHGPISDDTASLVVAQLLYLESEHPEKPIHLYINSPGGVVTAGLAIYDTMQYIRSPVSTLCVGQAASMASLLLAAGAVGERRSLPNARVMIHQPSGGASGQASDIAIQAREILDMRMRLNKLYVRHTGKDIEAIEQSMERDHFMSPEEAKGFGLIDEVIERRPVSLIADIVGGTVKA
179
Q8VSC3
2.3.2.27
ACT_SITE 337; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01398, ECO:0000269|PubMed:24248594, ECO:0000269|PubMed:29144452"
MLPINNNFSLPQNSFYNTISGTYADYFSAWDKWEKQALPGEERDEAVSRLKECLINNSDELRLDRLNLSSLPDNLPAQITLLNVSYNQLTNLPELPVTLKKLYSASNKLSELPVLPPALESLQVQHNELENLPALPDSLLTMNISYNEIVSLPSLPQALKNLRATRNFLTELPAFSEGNNPVVREYFFDRNQISHIPESILNLRNECSIHISDNPLSSHALPALQRLTSSPDYHGPRIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFEHEEHANTFSAFLDRLSDTVSARNTSGFREQVAAWLEKLSASAELRQQSFAVAADATESCEDRVALTWNNLRKTLLVHQASEGLFDNDTGALLSLGREMFRLEILEDIARDKVRTLHFVDEIEVYLAFQTMLAEKLQLSTAVKEMRFYGVSGVTANDLRTAEAMVRSREENEFTDWFSLWGPWHAVLKRTEADRWAQAEEQKYEMLENEYPQRVADRLKASGLSGDADAEREAGAQVMRETEQQIYRQLTDEVLALRLPENGSQLHHS
66
B3SC97
3.1.4.11
ACT_SITE 295; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 342; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"
MTVIKTNFKVDSDGFFVSWTENKEGMCLDMFMINEAKNGTLPKDQRVRDLIEKECGPNVSEARLLTIVYGYSLVDMKEIRLIASDAKSREIWKGGINKIIHDVISMNAPSDHFIKRSWVKLCCTGDADGNIQVKNIYKLVPSKLEDRVVDSLKALNLPNKKNAVIDPSKFPFSTFMSLYNKLCPRKDIEDIVMNRTGGKAPYLSIEQLRTFHNEEQRDPRLNELLYPFMKALQSKAIIDQYEPLEVLKGRGLITPEGLQYYFYSADSLIVPLEKLQLKAKDMDEPIAHYFINSSHNTYLVGKQFGGKSVVDMYRNVLLAGCRCIELDCWDGKGQDEEPIITHGKAMCSDILFKDVIEVIKEAAFIATDYPVILSFENHCSIKQQRKLAQYCLESFGDLLLTKPIDGYPTEPGKRLPPPSKLRGKILIKNKKLIKTEQDTEKENAAASKDTANSPTKDSNGTITTNSQNGIKSDSAASDTKKDGTDDAKPKINGSTTTKTTKGDSSEDPPAKKNLDPDVVAAVANYRYTGSTGNIDELLSSVVIYTQPVPFPGFEEAKQRNLHYNMSSFNESTGFGHFKASPTDYVNYNKRQLSRIYPKGSRVESSNFIPQIFWNAGSQMVSLNFQTPDLGFQLNQCKFEYNGMCGYLLKPEFMRRDDKQFDPFAENPVDGIIAADLAVQVISGQFVSDRKVNTYVEVDMYGLPVDTVRKKFKTKTVYGNSINPYYDSESFRFRKVIFPDLALVRFTVNDENGKMIAQRVIPFNAIQAGYRHVVLRNEWCNPIGLAQLFCHFKMKTYVPEGLDEMVEMLSQPLKFLSILDERSKKMQVYDVDEDEDVSAVVDETIEKAPSKDDSKPQTPAKPNAKATPKKSDSGSSSSNDSSSNESKAQMVRQTSAVGGMLDREPIKPVDIDELLKSKAFSKFFKKHQKEYHLVHKKHDKERFSAISQNLKQVNDLSMETFGKKSFIENKTKEKKSRQKTGNPEADLKSKYIARVKSLKGSPSKDKINALVTKHISESTDIAKRHEEDLQKFKNKASGIIWDQIKSLIINAFGDQIKNLEEQQKRDFAELRKGQAKRSMDDTKKIVIDRSENTDKEDRTRRHRELSQYNVKQFMEERKKLCGRHDREKKQLEKKQEEEMRSFESRKDEVNANQILYLNINR
153
A7T196
2.3.2.26
ACT_SITE 728; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
MVPESKYRFHNRHCLAKKGLQIYLFGHYLQPRFTKVKWEWQDPQVVGETLTFLLQIRHNYTPFTVKRTDIDIEIVHDGTPIACSLDFGGPGWQEMNRVKVTFTVRKSGDYNIAVLAMGEHITGSPFAKVFLPGSVDPAKCTIIERSSILVLQQGVYSPLLVEARDVYGNLRSISNAEDLLKYKVHIKKIGGSDSIDPELFVDSENRSNNSLHIKLEDEGIFQGTVSYDGTPVNNGELTIISLNDSEWYAVEKNIDRHCYNVWYEAALLPYPLTGSNTPPSIGNGADVARKSRKVYCYISPRNVSIKEFYMRIFPHKLHAFRVSPRTKFTLHPPNSNYEHPAFTISDGAQAPVSVVCRDRNVLVATYSRLVLLNIGGSESFKKKREFFNEKLLSHQGMKGGEVRLKINRSNLLESSYVACKNVDWLKMFNVTFEGEEGLDWGGVRREWFELLCIALFGRDSELFTRFKGDDPQAPVHPNPRRPPHLNLKYYKFAGQVVSKCIYESAISNARRQNVKAKFTRSFLAQLLGLRVNYKYLESDDKDLYRSKVQLIEKNDPADLELKFTEEEYNSSGQLEKVVELLPGGRLIDVTEQNKCEYLNLMARYKLVESVQKEVEAFIQGLNELVPDNLLGMFDENELELLMCGTGHISVADMKAHHHVLAGGGQRFTKIMDWFWTIVSSLTQEELARLLQFVTGSSQLPPGGFAELSPQLQISYIATSQALPTAHTCFNQLCLPDFPSFNEMQRKLLLAVNEGCEGFGFS
65
A0A2R6XHS3
3.1.3.16
ACT_SITE 289; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1"
MMAATNGFASSDLEKSEELKAAANVAFQAHRFSRAVDLYTKAIELNADNAVLYANRAFAHTRLEEYGSAIADATKSIECNPKYVKGYYRRGAAYLAMGKMKEALKDFRQVCKIVPKDPDAMKKLKECEKAVAKAKFEEAIALDSQSVATTLDYRTIEVEDSYQGARIEDKITLEFVKKMMDDFKNQKSLHKRYAYQILLQTHELLTVTPTLVDITIPPNGHFTVCGDIHGQFYDLLNIFQLNGLPSEENPYLFNGDFVDRGSFSVECIFTLFAFKCLYPTGLYLSRGNHESKSMNKIYGFDGEVKTKFNDTMSEMFTEVFCCLPLANVINGKIFVVHGGLFSSDGVKLSDIRAINRFREPPDEGLMSEILWSDPHDGIGRIPSKRGVGVAFGSDVTKRFLQDNNLDLVVRSHEVKDEGYEETHDGKLITVFSAPNYCDQMGNMGAFIRFEAPDLKPKFTTFSAVPHPAIRPMQYANNFFSMLA
144
D8R045
5.1.3.3
ACT_SITE 183; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 314; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"
MASDSKCVDVEAWGRKPGVYLYTLRNGGITARITNWGATIVSLCLRDPSAGEDIDIVLGFDSCDPYMDGTSPYFGCIVGRVANRIKDASFSMDGVTYTLPANNNMNTLHGGEVGYDKVLWQSQIVKESQVPAVEFTYRSSDGEQGFPGELDVSVTYALHENELRVEMRAVPASKQTPVSLAQHTYWNLAGHKSGSILDHTICISASRYTPVDDFQIPTGELAPVAGTAFDFLQEARIGSRIDQVEGGYDHNYVLDQKQGPGLCFAARVRDPSSGRTMELLTDAPGLQFYTGNFLVAEAGKDGQVYRKHAGLCLETQGFPNAVNDARFPSVMVSPGEVYRHQMVFRFSVTRKEKTKCLLE
211
Q54P47
2.7.11.1
ACT_SITE 840; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MSRKENLNRSSSSNSIEFNRDRDRDSSNISNSSNINCNNSSQTPPIPQHNSLSGRSKHSSPIHSLKKKGSLVRQGIEDLFSSLSVDTHSSSNSNNNSSSNNNNNNNNHNINSSSESSTPTTPRSSFTPQVTMNSNQSSGNNSPQLSSRSSSQSTLIPSNEPTKSLAKFFLLAQQVDYVGDSSSTLLPVENLGLLSIQWKTYFTIGLNSTTTGYDVLKYISIKTNRDLKSLTLADSDGKIIDNDYILTQQRCKKFVVVEDLNIDDLKMKQLNHLQQLPPPSQQQLPPPQSHQQQLLQQQLQQRLQNQNQNQNNNSNSNSNSSSSSSCSTPQSIVSQQQKLHQMLLNQQQIQSSQSTTPTNSSQKSSPNKVTDHQHVENCNFTSPSPSSPSSPSSPSSGMILDGFNLDGNGGRPTPLIITPSSPSSMRKNPPAIPPRSPSSFSGGSPLNNILLNNTELISEPVTTTTTTTTTTSSSSSLSVTTTISNPNYTQNLPTTPLSNSSSNNNNNGSFITLQDTTNNKSIINNNRESPPESPMGSRKSSGSSNTTSSTTNTTTPSSSSLTTSSGKESRDRDSKDKEKDLIGSGNNNNNNNNNNNNNNNNNKVEKEKENYCKFLDAVNSFNMVGNNGVLFNGEANRNMKLTNAQEEKCKILDNYFNHYYQELFKYLHQRHRRIKTIEDFTVESRMDRQGAEQWMKKQFEKETNFLRNKRAGMKLKEFKILTQIGKGGFGQVFLAQKKDTGDIVTLKRLKKQTVEWANQRNQVSQEKSVMLVDNKWITKLLYSFQDANYLYLAMEYHCGGDFRALLNNLGTLSEDEARFYMIEMIEAISSLHEMGIVHRDCKPSNFVLDKLGHIKLIDFGLSKEGIEKRNGWNKATMNELRKSCLSASFTSNTMKAASAYLSGGTNVMAYRRPIAHSAVGSPEYMSPEIVNDQGYDMTCDYWSLGCVFVEMLCGFNPFCADTPNDVFINILRWKETLDWPLFTQELSVEAADLLKNMLMEQPHRLGGKGKQDFKNHPFFKNHNWDEIVNGQVKPPFVPKVESDIDTSYFEDAVNNDSSTWDIDDNDCGGYGSGGYGGGGPQARDPFNNLKIPFFTYRKSSALSLSMSSEIAQSLNYNNGNTYSNYTSNNNNNNLHNNQIHEKNGNSGYNHFHFDSIEQQNQYQLSLLSPNSSDKSIGMIQYIKKFRYQQLQQQLQQHFQQQNHLQQLKSNHRKSPTRQLISSLLYKGDDKTSILQNYSSQSQPSLANQLQSSSSSPSPSLQSQSQSPSLQSSSKSTPNLSSSLLENPVKEELEYKNQTENEVEIKKENESEEIQSLRDQLKEIIIYEDYDQEYSI
99
T1EG16
2.3.1.286
ACT_SITE 186; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236"
MAEGGVDKKDSEEELHKEVVELDSKEVVKESACNNNFLQSIAAKFMGLFKSKPEDRSLVSVDLDGVVEFIRSGRCKNIISMAGAGLSTSAGIPDFRSPGSGLYDNLDEYDLPYPAAIFDLSYFKKNPEPFFVLAKNLLPTELIPTPCHHFLKLLHDKGLLMRHYTQNIDTLERLAGLPNEVLVEAHGTFNSGHCLKCRSKYDFDWMKNKIMSDTVPKCMKSGCKGVVKPDVVLFGENLPMKFFSLLIQDFSKCDLLIVLGTSLNVQPFASLVHKVPKKSPRLYVNLQKTSGSSFASWLIGGGSGFKFDDPDNERDVFWKGTCDDWCQLMAKKLNWECELNELITNQTTKIIK
58
A0A061ENE1
1.11.1.7
ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MKAGYSIFVLFVSLALFGIVEVCNARGAHGFSNLSYNYYRRTCPRAEKIVRGIIRERARINPALGAKLIRMQFHDCFVRGCDASVLLDTVNGSFPSEKKAVPNLSLSGFDVIDDIKTALEKACPKVVSCADILALAARDAVSAPFGRRLWDVPLGRRDGRISLASEINGNIPGPSANFSSLLQTFNKKGLDVNDLVILSGAHTIGVSHCGAFSRRLYNFTGKGDADPSLDRTYAIFLRKQCPNPASQTITVEMDPGSSLKFDTHYYDVLLQNKGLFQSDAALLTDGHSRGLVTTLRRKRSFFPAFATSMMKMGAIEVLTGNAGEIRANCRVVNP
14
Q6AX23
1.8.3.2
ACT_SITE 67; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 70; /note="Nucleophile"; /evidence="ECO:0000250"
MAAFVGLPLRSVPMLLLLLLLVVAGTARGETLYGPEDSVTILNKESVARAVFNSSSAWLLEFYSSWCGHCINYAPTWKALARDVRDWEPAIKIGVLDCAEEDNYGACKDFGVTLYPTFRFFKAFTKEFTQGENYKAVGDREIQTVRQVIIDFLQTSPAESKPQAWPSLEPISSSEISSLLTPKQSHYTAIIFESEESYEGREVILDLIQYSNIVVRRALPSDKPILEKLGIGSVPSCYLIQPNGLHGLINDVKSIRSQLSLHLKALSNVRKLLPSETAHSGLSKGVQQEDTTMNQFDRSKLYMTDLESGLHYILRAELANHHTLEGEKLKTFKDFVTILYKLFPGRPHVMKLLETLQEWLVSMPLDTIPYDAILDLVNNKMRISGIFLTNHTQWVGCRGSKSNLRGYPCSLWKLFHSLTVQAAVKPDALANTAFEAEPRAVLQTMRRYIREFFGCRECAKHFEAMAKETVDSVKTPDQAILWLWRKHNVVNNRLSGAPSEDPKFPKVQWPTSDLCSACHSQTGGVHSWNEDEVLAFLKRYYGNQEISLEFADPRKDLSEAATDNGNKEPHFTKKPQERDYVKKQNPQFLDKLVQKKPEKSLDSEAAESSQSVSFLGIGFSNIDMSLCVILYVTSSLFLMIMFFFFRFRSKRWKVRYNRPFV
38
E3KE05
3.1.1.5
ACT_SITE 1339; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"; ACT_SITE 1457; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU01161"
MVYIILQWFSGFISFQINFQKVLILIALLAFISSWTYKLKVLNKYSFLPKTPQLTKTFKNQDASRDLNPNLLLNSKQLFSNHDHFNNYLDEFLSAIRVFGFLEKPVFHELARHLQTRRLLAGDTLSLDEDKSFYIVVDGSVQVFAQTSDRARPGQNPGSPAGDAYNDRLAYDNEDDNGFQLLNVVESGGTLSSLFTILSLLTEGVKLRYEEDEGQTDQAFSPDFVDHSPQTSQGQPHHIPTVASSPSVLPPSASAVDPENNPGDWHAINPTESVPHDGRKFPDWNKDTNEDGGDTDDDGQSVETSRRSTYTSKTTTRQSLDRAGSRQALRKDASQTHPASGTINQMPDRDCDYGFARRTDPYASFSPTPQHHGPSYATDPTTKKPREAYSRHIRDQIFENAQPKEATIARATKDTTLAVIPSEAFKRLTWKFPNAVAHIVQVILARLQRVTFLTSHRYLGLTKELLRTEKAFNEIACYPLPPSFYEDGGMIRLRHRFMPSSKLTDEPYVLAGSHMSSDYHMNSGPRSSMNEFFKQPTTKTEPQQPWNDLYIDISRSTSQNGPCSPDSSGEQYPRRRSRHRYSNLSHDLSAPFQMPFSATNHLHEDLALRELVMKSIAKSIGLVQQPPPKNRGSNKGSVSHIHSSSPTPFSSASRAGFSPEPSIQGSGGGGGGGKPALRPGFRSGLGSLSYLKTLGDSSQERRDEFQDTSSSVASSSALLDEEEEKEDLPNEVEIMYFPQDSTLVKAGERNAGLYFVIDGFLDVFMPPEHDKMSPSNTSAEKPTSSSKKDHPSKARNVSDDNEFSYLRKDYVKMQKSRSTKSTRNPSKSSAAPKPTSQKSQQKPAPKNEQTKLFTIKPGGIAGYLASISGFPSYVDIRAKTDVYVGFLSAKALERIMDRRPIVLLTLAKRLISLLSPLVLHIDTALEWMAVDAGQIIYREGDNSDNLYIVIGGRLRSISEQTDGGVEILAEYGQGESIGELDCITNTSRKSTLHAIRDSELVRIPMTLFNAISIRHPAITIQVSRLIASRVRREVDASKSNSLKSRSHGPDYAVSTNRTGMPAPDEPGRGSIRELGMSNFNLKTVAIIPNTKEVPIVEFATRLKAALSQMNASTKMLDQSAILSVLGRHAFSRLGKLKLTGWLAELEQKFRIVLYVADTAVNAPWTQTCIRQADYIMVVCDGGSQPEVGEYERLLSSMKITARKELVLLHPDRNVPAGSTRPWLKNRPWLHAHHHVQMAGATPLNNNHLDELLPLTALRQLKRRVQTRLSKYRGYQMPSEFQIIKRGLANNDFARLARRLCGKSIAVVLGGGGARGISHIGVIKALQENNIPIDMIGGTSIGSFIGGLYARNSDLISTLGRAKTFSARIATYWRLLTDLTYPVVAYTTGHEFNRGIYKSFYDYHIEDFWLPFWANTTNITWSRMEVHTTGYAWRYIRASMSLAGLLPPLCDEGDMLVDGGYIDNLPVSVMLRMGADSVFAVDVGSIDDTSPRNFPESLSGWWLLIRRLNPWSSAYDIPTMTDIQSRLTYVSSVKTLEDAKATPGVLYMRMPVTEFTTLGFGRFEEILKKGYEAAKEMLKELDSEGKLPTGLDDGTNGSDSIIGIPGHRPYHNSKNGGNGSISENTKRQRLNVRRNSL
131
Q69PI0
3.1.1.11
ACT_SITE 452; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MSSAFGDFGPLTERRRAEKARQQRRRIMIALGTVSIIIILIVMGAAAITYSGKKSEEDEGGSKGSSKGKSKGGGGGDDEDGGGGGGKADLRAVSKSIKMMCAQTDFADSCATSIGKAANASVSSPKDIIRTAVDVIGGAVDQAFDRADLIMSNDPRVKAAVADCKELFDDAKDDLNCTLKGIDGKDGLKQGFQLRVWLSAVIANMETCIDGFPDGEFRDKVKESFNNGREFTSNALALIEKASSFLSALKGSQRRLLAGEEDNGGGAADPHLALAEDGIPEWVPDGDRRVLKGGGFKNNLTPNVIVAKDGSGKFKTINEALAAMPKTYSGRYVIYVKEGVYAEYVTITKKMASVTMYGDGSRKSIVTGSKNFADGLTTFKTATFAAQGDGFMAIGMGFQNTAGAAKHQAVALLVQSDKSVFLNCWMDGFQDTLYAHSKAQFYRNCVITGTIDFVFGDAAAVFQNCVLTLRRPMDNQQNIATAQGRADGREATGFVLQKCEFNAEPALTDAKLPPIRNYLGRPWREFSRTVIMESDIPAIIDKAGYMPWNGEFALKTLYYAEYANKGPGADTAGRVAWPGYKKVISKADATKFTVDNFLHAKPWIDPTGTPVKYDFFT
125
Q9ZU91
3.2.1.39
ACT_SITE 116; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 263; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317"
MAALLLLFLFLFASSALSQDSLIGVNIGTEVTNMPSPTQVVALLKSQNINRVRLYDADRSMLLAFAHTGVQVIISVPNDQLLGISQSNATAANWVTRNVAAYYPATNITTIAVGSEVLTSLTNAASVLVSALKYIQAALVTANLDRQIKVSTPHSSTIILDSFPPSQAFFNKTWDPVIVPLLKFLQSTGSPLLLNVYPYFDYVQSNGVIPLDYALFQPLQANKEAVDANTLLHYTNVFDAIVDAAYFAMSYLNFTNIPIVVTESGWPSKGGPSEHDATVENANTYNSNLIQHVINKTGTPKHPGTAVTTYIYELYNEDTRPGPVSEKNWGLFYTNGTPVYTLRLAGAGAILANDTTNQTFCIAKEKVDRKMLQAALDWACGPGKVDCSALMQGESCYEPDDVVAHSTYAFNAYYQKMGKASGSCDFKGVATVTTTDPSRGTCVFPGSAKSNQTLGNNTSALAPSANSTTSGCIPKYYHHPHASFGDLTLLSLLLIIALVFL
167
A0A9L0QYC6
2.7.10.1
ACT_SITE 824; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
MLSLSASSTQDYCHISVPAQRKEKAYMEVVFSTMIFETITNQDLPVIKCVLINHKNNDSSVGISSSYPTVSESPEDLGCALRPESTEAVYKAATVEVATSASITLQVLVNTPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEAANYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCVSESIPEPIVEWVFCDSQSDSCKGESPAVVRKEESVLHELFGTDIRCCARNELGRECTKLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELEHRALEEGSYFEMSTYSTNRTMIRILFAFVSSVGRNDTGYYTCSSSKHPSKSALVTILEKGFINASKSSENYEIDQYEEFCFSVRFKAYPQIRCTWTFSQKSFPCEQTGLDDGYSISKFCNHKHQPGEYVFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCSSDGYPLPSWTWKKCSDKSLNCTEEITEGIWNKKANRKVFGKWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGTFPFIQDNIFYATIGICLPFIAILTMLICHKYKKQFRYESQLQMVQVTGSLDNEYFYIDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLGNHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHQDLDHISGFNGNSFQSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVIRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNMDGHVSGRPSVYQNRRPYSREVDSGLPSPQAHVEDS
97
Q1L8L6
2.3.2.31
ACT_SITE 288; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221"
MGSEKDSESPHSSVSGIPNPKCRGPGKKQGRISFHSLFHSKRGPRGSKANVGTPLAQQLHQQQQIQQQQLLQPPTPTNVSSDPSTADPAEPLSTSQASLGGQELLECPLCLVRQPAEQLPELQGCSHRSCLCCLRQYLRIEITESRVQLSCPECAERLAPWQVALILDDPNLMEKYEEFLLRRCLASDPDCRWCPAPDCGFAVIASGCASCPRLVCRREGCGAEFCYHCKQAWHPNQTCDSARQQRALSLRTHSNHSPSYTAEQGHTDDIKPCPRCGAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGITLIAGIAVPAMVIGIPVYIGRKIHSHYEGKKTSHHRRNLAITGGVALSIITAPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSRGKGRGVRIDFDEDDGPITVADAWRALKSPSLGESSLEGAASGLSTTSPSEGLSVAPGGLGDTPHFNTLAGGALGARTGKYSRLEVQGTELGKEVAGRETGSLGAASDCASTRGMAGSITSSYTLPDREGTNLEIQVDIETKPSHLCLTTEEDLAPPTAAMAPGVGEEPQDCSSRRSRTVMDSPLGLSPGMSLREGLRDVTLAQPESIRSDLEMSDTQSDDIAELTSDDCDSPHPKSCHGAPPQATCRALNPTDSLHCPDNVILYV
67
P06278
3.2.1.1
ACT_SITE 260; /note="Nucleophile"; ACT_SITE 290; /note="Proton donor"
MKQQKRLYARLLTLLFALIFLLPHSAAAAANLNGTLMQYFEWYMPNDGQHWKRLQNDSAYLAEHGITAVWIPPAYKGTSQADVGYGAYDLYDLGEFHQKGTVRTKYGTKGELQSAIKSLHSRDINVYGDVVINHKGGADATEDVTAVEVDPADRNRVISGEHRIKAWTHFHFPGRGSTYSDFKWHWYHFDGTDWDESRKLNRIYKFQGKAWDWEVSNENGNYDYLMYADIDYDHPDVAAEIKRWGTWYANELQLDGFRLDAVKHIKFSFLRDWVNHVREKTGKEMFTVAEYWQNDLGALENYLNKTNFNHSVFDVPLHYQFHAASTQGGGYDMRKLLNSTVVSKHPLKAVTFVDNHDTQPGQSLESTVQTWFKPLAYAFILTRESGYPQVFYGDMYGTKGDSQREIPALKHKIEPILKARKQYAYGAQHDYFDHHDIVGWTREGDSSVANSGLAALITDGPGGAKRMYVGRQNAGETWHDITGNRSEPVVINSEGWGEFHVNGGSVSIYVQR
157
A0A7M7MY35
2.7.11.13
ACT_SITE 494; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50"
MVFLRVRVLQVDSKEIELPGSVLFDPFVAVNVKESVKDANGQTQLRQKRKTAFVEWNKCFDSHLYDGRVIQVIVYNRPESYLAEANYKVNELAAMCGMDGRIETKWLDLMPYGRLQVQLRCFPEEGGGGDPMNSVRSTVSHHNSDMDKKDDTTGLLTKRRVAIRKAKVHEHRGHKFTPHYFRTPAYCSYCNEFIWGLVGTQGYRCMECELSVHKRCFNQVLGKCPGTGVNSTETKKLKERFNINMPHRFKVNNYKSPTFCDHCGTMLYGLFRQGVKCEVCNVNVHHKCKNNVPNLCGVNQRLLSEALSSIEITKSMKDKKLPPGAGNGKHGYVPDDDEDLDEAVYEPLWTTDGGPPDRPVAVQKYSIDDFMLQKVLGKGSFGKVMLAEQKGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEKRARFYAAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGEDEDQLFDCILHDAPHFPRWLTKDAHSCLIQLLERTPEVRLGVKGDVRAHQFFKSIDFEKLERRELPPPFKPKIKSDGDASNFDPEFTMEKVALSPTDTSMLSSINQRQFRGFSFTNPTMAEK
100
A0A0G2KJW7
3.4.19.9
ACT_SITE 133; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1"
MGFSVLVSACACVCVCVYVSAAPLGDEAENDRPIIGILTQEVDSEVMRKFGNTYIPSSYVKYIESAGARVVPIRLNQSFAEHEKLFKSINGLFLIGGAVNLETSDFARTAGFYFRLALKANDQGDYFPIWGTCLGFQLLTVLVAGENLLSKTTAENVTYPLNFSSEALSSRMFSSFPSELRRALSEEPLTANFHHYGVTKEAFMNNEKLTGLFSVISTNIAQNGAEFVSTIEGRKYPFYGVQWHPEVNRFQWNPHYSFPHSSNAVHVSSLLAQFFVNEGRRSTHRFSDAAEESAVLIYNCNPVYVEKISAYEQSYFF
176
Q9HVQ3
4.1.1.17
ACT_SITE 335; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MSIKVEDYFAPETFQRMKAFADKQETPFVVIDKQTIADAYDQLTDCFPFARIYYAVKANPATEITELLRDKGSNFDIASIYELDKVMKTGVGPERISYGNTIKKSKDIRYFYEKGVRLFATDSEADLRNIAKAAPGAKVYVRILTEGSTTADWPLSRKFGCQTDMAMDLLILARQLGLEPYGISFHVGSQQRDISVWDAAIAKVKVIFERLKEEDGIVLKMINMGGGFPANYITKTNDLETYAEEIIRFLKEDFGDDLPEIILEPGRSLIANAGILVSEVVLVARKSRTAVERWVYADVGKFSGLIETMDESIKFPIWTEKQGEMEEVVIAGPTCDSADIMYEHYKYGLPLNLASGDRLYWLSTGAYTTSYSAVEFNGFPPLKAFYL
195
Q8INB9
2.7.11.1
ACT_SITE 389; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MNYLPFVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKFSWQQSWPSRTSAAPTHDSGTMSINTTFDLSSPSVTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGDMASTLGTSSHISTSTSLASMQ
99
A0A8J1LDZ9
2.7.10.1
ACT_SITE 800; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1"
MARGSLLLLPLLLLLLSPLTRALEETLMDSTTATAELGWTVRPTSGWEEVSGYDENMNTIRTYQVCNVFEVNQNNWLRTKYIRRRGAHRIHVEMKFSVRDCSSIPNVPGSCKETFNLYYYESDFDSATKTFPSWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSKSGFYLAFQDYGGCMSLIAVRVYYRKCPRIIQNGAIFQETLSGAESTSLVAARGNCIPNAEEVDVPIKLYCNGDGEWLVPIGRCLCKAGYESVENGTVCRACPSGMFKANQGDDSCLHCPINSRTTSEGATNCVCRTGYYRSDSDPLQMPCTTIPSAPQNVISSVNETSLMLEWAPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQFAPRQLGLMEPRVYISDLLAHTQYTFEIQAVNGVTDQSPYSPHFSSVNITTNQAAPSSVSIMHLVTRTIDSITLSWSQPDQPNGIILDYELLYYEKDLTEHNSSVAKSSTNTVLVPGLRAGTIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQSSFQEKLPLIIGSSAAGLVFLIALVVIIIVCSRRRGFERADSEYTDKLQHYTSGHSTYRLPSPGLGSRSLVVTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREMFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRVFSWVFTSYEMPGGTDGRMWVAPYKHCYPCVFQQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPNALHQLMLDCWQKDRNHRPKFGQNVNTLDKMIRNPNTLKAVAPLSSGVTLPLLDRTVPDYTSFSSVDEWLDAIKMAQYKESFANAGFTSFDVVSQMSMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEV
97
A0A8V0YTP2
2.7.11.1
ACT_SITE 1931; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR629601-1"
MSQKSWIENTFTKRECVYIIPSSKDPHRCLPGCQICQQLVRCCCGRLVRQHACFTASLAMKYSDVKLGENCNQEIEEWSVEKHTEQTSTDAYGVINFQGGSHSYRAKYVRLSYDTKPEAILQLMLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWIITGGVNTGVAKHVGDALREHASRSSRKICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVGKYGAEVKLRRELEKTINLQRIHARIGQGVPVVALVFEGGPNVILTVLDFLHESPPVPVVVCEGTGRAADILAYVHKQTEEGGNVPEGAEPEIISTIKKTFNFGQSEAVHLFQTLLECMKKKELITVFHIGSDEHQDIDVAILTALLKGTNASAFDQLVLTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTIPRLEELYNTKQGPTNPTLFHLVRDVKQGNLPPGYKINLIDVGLVIEYLMGGTYRCTYTRKRFRAIYNSLSGNNRRSGRNPSNTTPQLCKSHESFGNRADKKEKMRHNHFIKTAQPYKPKIDTGAEEGKKKRTKDEIVDIDDPETRRFPYPLNELLLWAVLMKRQKMALFFWQHGEESMAKALVACKVYRSMAYEAKQSDLVDDTSEELKQYSNEFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQMLLSDMWMGRLNMRKNSWYKVILSILLPPAILLLEYKTKAEMSHIPQSQDAHQMAMDDSENNFQNTADEIPMEVFKEVRILDSTTEKHDMETPAKPKRLPITQKFYAFYHAPIVKFWFNTLAYLGFLMLYTFVVLVKMEEVPSVQEWIVIAYIFTSAIEKIREIFFMSEAGKINQKIKVWFSDYFNISDTVAIVTFFIGFVLRFGAKGNFGENTYRENYIFVAGRITYCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYPNEAPSWTLARDIVFHPYWMIFGEVYAYEIDVCANNSESQVAHLCGPGTWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPVLPPPLIILSHMASLLCCICKRRKTDKTSDGPKLFLTEEDQKKLHDFEELCVEMYFNEKDDKFHSGSEERIRVTFERVEQMCIQIKEVGDRVNYIKRSLQSLDSQIGHLQDLSALTVDTLKTLTAQKASEASKVHNEITRELSISKHLAQNLIDDGSLRSSVWKKHSIGNVFGSFPQGGLENNNALLCNVLIRDDKEVQHKTIGQELAQVARREEINLQEAGSSGSALFSNVVSPPELRQRIQASEISKSSSRSKKLGNSSNSMPHVTSPTAKFFVSTPSRPSCKSQLDSSTKHEETVCSKATEGDNNVEFGAFVGKYNKVDSECPEVIISCSYPLASGSACLAFTQPCVENGGYINCGFIHDESDTNDNYSCRVDKCDHQSSVNLTKNKPQTKLSLSTGDLTSTVNDSHGKLNVKDELSKSQHVHAMELQNQDLCSNILMGLLHKLWTKSKPQGHRDSMELQRFKEAASKIKERSTDIEEQQEDFKKAILEGIETTRLQGLQTDCGLRQSSSCGGFTDPLAAHSEQLPSKSRRASSEDAQQVDSKAALLTDWLQGRPSSSSQMASEEDALNGIASPFKPIMDINYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNILNNSMSSWSQLGLCAKIEFLSKEEMGGGLRRALKVVCTWSEYDILKSGHLYIIKSFLPEVVNTWSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWFAVEECMTGEFRKYNNNNGDEIIPTNMLEEVMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKAGEKRSYDMVFGPANLGEDAIKNFRAKHHCNSCCRKLKLPDLKRNDYTPDKVIFPQDDSPELTIQPGSCTKESDSANSLRLML
99
Q2QM77
2.7.11.1
ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MVAAVRAPVKPEMVELSPAAMERYSSDADTTAPNSSLSSAASSTGSLARCSSLSRLSFDCSPSAAVAAAATSCSPPRASVLLRPHRSGDVAWAAIRAASTTSAAPLGPRDFKLVRRIGGGDIGTVYLCRLRSSPERESPCMYAMKVVDRRAVARKQKLGRAAAEKRILRQLDHPFLPTLFADFDATPHFSCAVMEFCPGGDLHSLRHRMPSRRFPLPSARFYAAEVLLAIEYLHMMGIVYRDLKPENVLIRADGHIMLTDFDLSLQSTTSPSLDGDTDTDDEASGGASCFPDHLLRFKRRRNAVAAPRPRFVAEPVDARSCSFVGTHEYVAPEVASGGAHGAAVDWWAYGVFLYELIYGRTPFAGATNEATLRNIVRRPLAFPSGSGSCGPADADARDLIARLLAKDPAARLGSRRGAADVKSHPFFKSLNLALLRSSRPPVVPGAGAGAAPLHRSQSCKAAPTTPPPPTTTKPANATARFDLF
99
Q4WN54
2.3.1.225
ACT_SITE 153; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250"
MCYYISILIYWGADCRTVGTGPVLMYCTKTIRSYFRCRHPFFSSINSSQIFFLSLLIAGECMFIPSAWPRVSTFHRLFIPALALLPYVFLYASVVTKSYITHENHEDEMARYPYDRVIFNPGHRCRTCDFLKPARSKHCSFCKACVSRHDHHCVWLTNCVGRNNYHYFLSLLLSLSLMLAYGSWLGFSLVSQTLEGLIPSSSPLRSKSQDWTTWLNVWAIAIASDIRVGAVAMLTAMTAPLAMAFLLYHTYLIWAGMTTNESAKWSDWKEDVADGLVFKSTRSEIYGNQSHSDEDTPAQRTWPVSSNQILVITDGEPPKEGFQLCSRSNEILQKDDPQAPVDTRWTEVNSMREIDNIYDLGFWDNLREVFHMPIRRCVR
57
A0A8M2BEG2
2.1.1.37
ACT_SITE 1275; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFESQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFEARDGQEIVPVDDVMKSPKALKSSYESGRAGEESDMEINGGRRSATYDPKWQRNLKWIRASDMGDNYAYCTTCDYNIILLAGFHDLKRHQLTQNHMKHETGRTNLPGRKQIEESISCSETMLLFIQSHCLSSLPSRINRVSQRTARCILGLKYPNDIVSACKLNPYCIYIYGQVPLDVKTGDKTNCHVVLAGFFEEKQARYCIRFLDVFQPEDSASSVSGGLFSILKKFEIPASNMVAVYINDHELTSESVVSQIRELNPQVIDLGGLYSIPDTACSAGLQTHSVQVQELIANIYRHFSTGSTSNDNLKMLFAGIDGLKVHSNPLSNSEEFCVLVKRIHEMWSDLVSYFSSCDENNDNVKQICSQLENPKIRLTLMFLDQALGPLRAFGQHLQQSKSSVRADLVEILREASGLLRSYASSFLRPQAVIRYLKEQDPAILDNEAFCLPAAELSLGGVLEDFISAREEELADFLSTFYNECLAIYKTLTTSIAASLPLSDSVLRAISQLLSPAGRLKVTGKNIVDLAVRFGFCSKPEDSAKLNDEFLEYQLAEEENLSSTHSIERYWCTVLKTFPPTSVFKRLVLCLLVLPSPSLDATKIFAQAIENGDADQLDDSSSESDTDMTKELDSNDDNSLDNSELQISPIKNGIMKKSRRSTSEVNLKNDGAKNDGTLTSNTLKEDSIRGIHGWECSLRQKPQARTVFQAGAGTWSKPAIQDVDRKPEAVKNDLSNSTPSPRRGKRDQAYNDGKGFAVGELVWGKVKDFSLWPGLVVPWKGRIVPVSMRRVEWFGDGMFSEIHTDGLLPFGAFSKNFCSKSYEGLPTYKNAIYQILELAAERSGKLFPPSEKKGEEVKAMMDWAFGGFQPMGADGFLPSADSSASNKTESDSSVSDYQPPAKRKYVFKNRPSTQECNRDQMVQEVTSKGRKIEDFCLSCGSSNTEIFHPLFKGSLCIKCKENFTETLYRYDDDGYQSYCTVCCAGLEVILCGNASCCRCFCKDCLNVLVGPGTFDKLKEVDPWSCYVCLPSKCYGVLKLRTDWSVRVQEFFANNSAFEFEPHRVYPSIPAHKRRPIRVLSLFDGIATGYLVLKDLGFKLERYIASEICEDSIAVGMVKHEGKIEYVKDVRTITRKHLAEWGPFDLLIGGSPCNDLSMVNPARKGLFEGTGRLFFEYYRMLTMMRPKEDDDRPFFWLFENVVAMSAHDKADICRFLECNPVMIDAVKVSPAHRARYFWGNLPGMNRPVATSLTDNVDLQDCLESGRTAMFSKVRTITTKSNSIKQGKTGPLPVTMNGKEDYLWCTEMEKIFGFPKHYTDVNNMGRGQRQKVLGRSWSVPVIRHLFAPLKDYFACE
47
Q8CIR4
2.7.11.1
ACT_SITE 1929; /note="Proton acceptor"; /evidence="ECO:0000250"
MQVKKSWIEGVFYKRECNKFIPSSKDPHRCTPGCQICHNLVRCYCGRLIEEHHGLDRAWNLSVTEGHGDEQWSVEKHTVKSPTDTFGTINFQDGEHIHHSKYIRTSWDTKSDHLLHLMLKEWNMELPKLVISVHGGLQNFKISSKLKETFSQGLVKAAETTGAWIITEGINSGVSKHVGDALKAHSSKSLRKIWTVGIPPWGVIENQRELVGKDVVCMYQTLGNPLSKLTTLNCMHSHFILCDDGTVGMYGNEEKLRRNLEKHLSMQKIHTCSRQGVPVVGLVMEGGPNVILWVWETVKNKEPVVVCEGTGRAADLLAFTYKHLEDGGILRPQVKEELFCLIQNMFNFSLRQSKHLFQILMECMVHKDSITIFDADSEEHQDLDLAILTALLKGTSLSISEQLNLAMAWDRMDIAKKHILTYGQHWKPGALEQAMLDALVMDRVDFVKLLIENGVNLHRFLTIPRLEELYNTKQGPTNKFLRHLVQDVKQHTLLSSYRITLIDIGLVIEYLIGGAYRSSYTRKSFRILYNNLYRKHKSVSSFAQGLSQHSLHQRHSLRNRKESSESTLHSQFFRTAQPYKSKEKPEDSQKSKKKSKERQSLSEEPEAAGFIYPYNDLLVWAVLMKRQNMAMFFWQHGEEATVKAVIASILYRAMAREAKESNMVDDTSEELKNYSEQFGQLALDVLEKAFKQNEPMAMKLLTYELKNWSNSTCLKLAVSGGLRPFVSHSCTQMLLTDMWMGRLKMRKNSWLKIIISILLPPMILTLEFKSKAEMSHVPQSQDFQFTWNYSDQGLSNTKESACVKDYDLERGPDEKPDEPLHLDLRNVPQSLPWTRRVYEFYSAPFVKFWFYTMAYLAFLMLFTYTVLVEMQPQPSVHEWLVIIYIFTNAIEKVREICISEPSKFKQKVKMWLSEYWNLMETVAIGLFAVGFGLRWGHPPLQTAGRLIYCIDIIFWFSRLMDFFAVNQHAGPYVTMIAKMAANMFYIVIIMAIVLLSFGVARKAILSPKEPPSWRLARDIVFEPYWMMYGEVYASDIDVCSNETSCPPGSFLTPFLQAVYLFVQYIIMVNLLIACFNNIYLDIKSISNKLWKYNRYRYIMTYHQKPWLPPPFILLNHLCLLLRGLCCRPAPQDQEEGDGGLKLYLTKDDLKKLHDFEEQCVEKYFHEKTEGLNCSFEEQIRMTSERVSEMFFQLKEMNEKVSFIKDSLLSLDSQVGHLQDLSAITVDTLKVLSAVDTLQEDEILLANRKHSTCRKRPHSWTNVICAKVLSDMESCGKKKLQYYSMPPSLLRSLARSQLPPSVQRGALVEVTHSKREASHVREEQEEREMEQRTTASGISHVRQAHSKYGQFLLVPSSGKQVPLSLETPPHLFRSSEEAGIDGLVLEHIHQSDLTTHLPQQTPAASHQALVAEHKDQHEAVTQMSDKPAKAEQDLLAFSGTPAPMTVTSLPSRAISMQDEGGYVNWAFSENDETGVFSFKKKWKTCLASTCNSDSNPGGDYFLHTGGRSGLDNSRRLAQSCECPAGPWTQARRSFWINPLCRDKALIKSHSFRFHKEEKLRKTWKNNSHSKSLETRSTWLKAKLLTKTRSLSKKKRKTQGLQVPVITVNACYQSDQLNAEPGETNTTEEFSKKWLSVSNFSQIGLEPYIYQKMKMKEIKRHTTQASDHLRQPQENRDKTPTWNSGSTSLSRSFLTRSPNEVHKISTSLKSPQEPHHHYSAIERNNLMRLSQTIPFTPIQLFTGEEVTIYKLEESSPLTLDKSMSSWSQHGRAAMIQVLSQEEMDGGLRKAMRVISTWSEDDVLKPGQVFIVKSFLPEVVQTWYKIFQESTVLHLCLREIQQQRAAQKLIYTFNQVKPQTIPYTPRFLEVSLVYCHSANQWLTIEKYMTGEFRKYNNNNGDEIAPTNTLEELMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEDKQSRGMVFGPANLGEDAIRSFIAKHRCNSCCGKLRLPDLKRNDYSLSRTHCNLGFGQTIEPTEELPERDKNRSSLEDHTRL
99
Q9ZV85
3.4.19.9
ACT_SITE 166; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"; ACT_SITE 279; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"
MWRFCFFLSLLFFDVSAVKSAESIFLPSQIGVEDSRVFESLSLSPVCSAADPNLNYKPVIGILTHPGEGRWDARLHSLKNYAYATNISYIAASYVKLAETGGARVIPLIYNEPEEILFQKLELVNGVIFTGGWAKTGLYYDVVEKIFNKVMEKNDAGEHFPVYAMCLGFEILSMIISQNRDILERFNSVNYASSLQFFKNVNIEATVFQRFPPELLKKLSADCLVMQNHYFGISPDNFQGNPYLSSFFNIVTTSADKDSKTFVSTIRSKRYPVTAFQWHPEKNAFEWGSSEIPHSEDAIQVTQHAANYLVSEARKSMNRPSSEKVLSNLIYNYKPTYSGYKGSGDDEVYIFT
176
D8RPL5
1.11.1.24
ACT_SITE 45; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
MGLNLGDIVPDFKAESTMGTIKFHEYINGSWAILLSHPSDFTPVCTSELGSLASRIHEFDRRGVKVIALSCNDVNSHREWLGDIESYCPETKVKYPIVADPSRDLAVRFGMLDPVEKDAAGMPLTCRACFVIGPDKRVRLSILYPASTGRNFSELVRVIDSLQLTDKFSVATPANWENGRKCMILPTISDEKAKEMFPKGFDTVKVPSGKAYIRLVEQPTL
12
P50527
2.7.11.1
ACT_SITE 505; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027"
MERGTLQPRKKAPNGYGITPIVAHKTGEPVRYEVEDDLRKLKPSRTAPKPPAINTNLAEDTFSGFPLSQSRTTVSRVSLGSRQHSSSSIRKLQTNVSDVRSYDERNQKKSAFENFVSSMSSFLTGGGSSPTSSYGSGSASPRKSTVISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLEEGAKPPFPRESTEKPLLSVSALSSSSHLQPTSATSSSSRLYPSRPAPTPPASSSSSPLLSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQTLSTSETKHIRPNNSTPYQRRAETSTKPKAVATPQKVEAPSAPRLQKRAPRQQSNDSAVLAKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFLKQAVPVSSLIPLIKSIHHSGK
99
A0A0K9NSC3
3.1.1.11
ACT_SITE 371; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040"
MAKNFITFATLFLLFLTLHVYGGDSIGTFTKFTSCSQLPHPKACYSLTQNADPLYAGGKVKSGFREFNIQGAMSGFRRVHVEVAAVDVAKFDSRTRGAWDDCVALGEETIEHLRNSVENPSSEETQTWLSAAAANQQTCADGFFDLGLIPPPSMANLLSSNITDLLSNSLAVNVPEPTISGRNRKLFSVGGGDGNDDLFPEWLSDDDSRRLLRSVSVKANLVVAKDGSGNYKTIKEALSHVSGKRRGNRRFVIYIKAGVYKENVEVKKSMKNLMFVGDGIDRTIITGKRSVKDGWTTFRSATFAVAGKGFIAKGMTFQNTAGAMKHQAVAMRSDSDMSVFYRCSFKGYQDTLYVHSQRQFYRECDIYGTVDFIFGDGVVVLQNCKIYVRKPMRNQKNTVTAQGRSDPNENTGISIHRSVIKAASDFRSSQGKIKTFLGRPWKRYSRTVFMRSNLGGLIAPAGWLKWNGNFALKTLYYGEYSNTGAGSSTKRRVKWGGYHVMSSSMARKFTVGKFLVGNSWIPVSRVPFTSNL
125
A0A9R0JPA0
1.11.1.7
ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1"
MAAQNSKIIFFSAFILLSVAVFGSQAALDNHYYDQTCPQAEYIISQTVLNASIYDPKVPARLLRMFFHDCFIRGCDASILLDSTPGNKAEKDGPPNISVRAFYVIDDAKAKLEKACPHTVSCADVIAMAARDVVTMTGGPYWKVLKGRKDGRLSKASDTTNLPPPFLNADQLIQTFANRGLGIKELVALSGAHTLGFSHCASFVARVHNFSTIHETDPSMNAEFASMLKKKCSRSNNNGDAGQFLDSTASRFDNDYYRQIIAGKGVFGTDQVMYNDQRTRSMIEAFAKDQNLFFREFAASMIKLGNVGVNEVGEVRLNCRRMN
14
G7J5X8
4.1.1.17
ACT_SITE 369; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
MPTLVTEESQSQITNLKPIFCASGVKGNKVTTLSSEVTISDFIQSIIKTKPTENDSPFSVLDLRVIIDLMNKWTTELPTVKPFYAVKCNPNISLIGTLASLGSNFDCASRAEIESVLSLGVSPDKIIYANPCKSESHIKYAASVGVNVTTFDCAGEVEKIKKWHPKCELLLRIKPEEDSGARSCLGLKYGALHNEVPELLKAADMAGLKVTGVSFHIGSGGADAKAYHGAILLAKEVFETASRLGMPKMKILDIGGGFTSGSKFDEAAFNVNDAIKTHFGNDEDLVVIGEPGRYFAETAFTLATKVIGKRVRGEMREYWIDDGIYGTLNNIVFDYAIVKCMPLRFGSKPENVICKDPKTYPSTVFGPTCDSVDTVLKEYELPELKVNDWLVFPNMGAYTTSSGTNFNGFSSSAEHIHIACSTPSLVGR
195
P44309
2.7.1.21
ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00124"
MAKLYFYYSTMNAGKSTTLLQSSYNYRERDMNTLVYTAAIDDRFGVGKVTSRIGISQDAFLFRSETNLFDEINEHLKKEKVHCVLVDEAQFLSKQQVYQLSDVVDKLKIPVLCYGLRTDFQAELFEGSKYLLAWADQLEELKTICYCGRKANFVLRLNDQGEVIKEGAQIQIGGNDSYLSVCRLHYKEKCGQI
88
A2FPH6
2.3.1.48
ACT_SITE 268; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
MDLTKGDIVSAFCEELQTYLKGEVVTSRQTAKGQQVYVHFFKQDKRLDKWYDIDQLEKTDLDSEELKESKLNSYSQFGAAYEDFEKLHDQVTKIRNIDLVTIGKYTIKTWYYSPYPDEFNQLDHIFVCDKCFRYFKTQEELDSHMQGERPYPPGKEIYRNENISIFELKGNSQKLSCQCLCLLSKLFLDHKTLYYDVEGFNLYVLCELGDDDQVHIAGYFSKELDSSDNNILACITILPPYQKKGYGFLLISLAYEIARREGKVGGPERPLSDLGKIAFSSYWREVIISTLKDKLTEIKYISDIVKLTYIDEDDVVDTLKPLNLVESYRGEYELLESKDDILNIIDKIPTKRMIYAVDAKKLIWLPSELIHPNSQ
61