spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.20580662786960602, "1015": 0.34023189544677734, "1016": 0.4487839937210083, "1047": 1.06349778175354, "1050": 0.7144040465354919, "1164": 0.5805994272232056, "1999": 0.021256839856505394, "2004": 0.03925827145576477, "2005": 0.06612417846918106, "2008": 0.11778303235769272, "2011": 0.026976587250828743, "202... | 6493422 | Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo. Exposure of... | The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. |
{"1011": 0.009718249551951885, "1015": 0.7144040465354919, "1039": 0.9108069539070129, "1040": 0.12556517124176025, "1052": 0.7701805830001831, "1053": 0.04674193635582924, "1999": 0.1011524572968483, "2007": 0.20022670924663544, "2008": 0.05786345899105072, "2012": 0.3416208028793335, "2015": 1.0298984050750732, "2028... | 6501747 | Dendritic cells (DCs) play a critical role in the immune response to viral infection through the facilitation of cell-intrinsic antiviral activity and the activation of adaptive immunity. HIV-1 infection of DCs triggers an IRF3-dependent innate immune response, which requires the activity of cyclic GAMP synthase (cGAS)... | PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1 |
{"1042": 0.5045560002326965, "1052": 0.75193190574646, "2000": 0.1619328260421753, "2003": 0.42353010177612305, "2004": 0.6833335757255554, "2005": 0.3683255612850189, "2008": 0.022212404757738113, "2011": 0.3381449282169342, "2045": 0.46363574266433716, "2047": 0.43623676896095276, "2064": 0.012615402229130268, "2073"... | 6503185 | Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concern. Evidence is accumulating that resistance to artemisinin derivatives, the frontline therapy for the asexual blood stage of the ... | Malaria biology and disease pathogenesis: insights for new treatments |
{"1003": 0.12642613053321838, "1011": 0.30486753582954407, "1015": 0.42161011695861816, "1022": 0.11517547070980072, "1043": 0.1751343309879303, "1045": 0.5517725944519043, "1048": 0.8074519634246826, "1050": 0.07793712615966797, "1052": 0.5133614540100098, "1053": 0.5668440461158752, "1054": 0.6773988008499146, "1059"... | 6503534 | A group of 27 Italian patients was screened for α-L-iduronidase mucopolysaccharidosis type I mutations. Mutations were found in 18 patients, with 28 alleles identified. The two most common mutations in northern Europeans (W402X and Q70X) accounted for 11% and 13% of the alleles, respectively. The R89Q mutation, uncommo... | Mutations among Italian mucopolysaccharidosis type I patients |
{"1014": 0.5712664127349854, "1019": 0.06977381557226181, "1044": 0.03360854089260101, "1049": 0.09228714555501938, "2001": 0.19782574474811554, "2012": 0.33953672647476196, "2020": 0.23402166366577148, "2022": 0.12986256182193756, "2043": 0.18167030811309814, "2044": 0.06429435312747955, "2052": 0.1510767638683319, "2... | 6504953 | Abstract Pierce, D. A. and Preston, D. L. Radiation-Related Cancer Risks at Low Doses among Atomic Bomb Survivors. To clarify the information in the Radiation Effects Research Foundation data regarding cancer risks of low radiation doses, we focus on survivors with doses less than 0.5 Sv. For reasons indicated, we also... | Radiation-Related Cancer Risks at Low Doses among Atomic Bomb Survivors |
{"1014": 0.2763880789279938, "1017": 0.37035053968429565, "1019": 0.2954642176628113, "1020": 0.49982786178588867, "1021": 0.03925827145576477, "1022": 0.3850763738155365, "1042": 0.02887592278420925, "1998": 0.12384103983640671, "1999": 0.036437395960092545, "2000": 0.27044451236724854, "2004": 0.37907835841178894, "2... | 6517267 | BACKGROUND The Dutch multidisciplinary sciatica guideline recommends that the team of professionals involved in sciatica care and the patient together decide on surgical or prolonged conservative treatment (shared decision making [SDM]). Despite this recommendation, SDM is not yet integrated in sciatica care. Existing ... | Barriers and facilitators to implement shared decision making in multidisciplinary sciatica care: a qualitative study |
{"1011": 0.013579257763922215, "1013": 0.07884006202220917, "1015": 0.32199856638908386, "1016": 0.3070250153541565, "1020": 0.04487626627087593, "1043": 0.947819709777832, "1051": 0.00875066313892603, "2007": 0.04487626627087593, "2028": 0.11256109178066254, "2033": 0.6669275164604187, "2042": 0.08154398202896118, "20... | 6517763 | The prognosis of glioblastoma, the most malignant type of glioma, is still poor, with only a minority of patients showing long-term survival of more than three years after diagnosis. To elucidate the molecular aberrations in glioblastomas of long-term survivors, we performed genome- and/or transcriptome-wide molecular ... | Molecular characterization of long-term survivors of glioblastoma using genome- and transcriptome-wide profiling. |
{"1011": 0.10291612148284912, "1013": 0.15359249711036682, "1014": 0.4412745535373688, "1023": 0.33605360984802246, "1041": 0.07793712615966797, "1042": 0.012615402229130268, "1052": 0.9060825705528259, "1055": 0.04394211992621422, "1058": 0.38308101892471313, "1059": 0.055094651877880096, "2003": 0.00875066313892603, ... | 6525844 | BACKGROUND Damage to large arteries is a major factor in the high cardiovascular morbidity and mortality of patients with end-stage renal disease (ESRD). Increased arterial stiffness and intima-media thickness, together with increased pulse pressure, are the principal arterial alterations. Whether increased aortic puls... | Impact of aortic stiffness on survival in end-stage renal disease. |
{"1011": 0.33605360984802246, "1039": 0.6911921501159668, "1049": 0.21135559678077698, "2003": 0.1510767638683319, "2005": 0.08692999184131622, "2006": 0.8004589080810547, "2007": 0.016465263441205025, "2010": 0.18248429894447327, "2011": 0.010684899985790253, "2026": 1.3590717315673828, "2029": 0.27342069149017334, "2... | 6532806 | We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparison... | An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets |
{"1011": 0.401551216840744, "1053": 0.02792670577764511, "2003": 0.20102575421333313, "2005": 0.02412080205976963, "2015": 0.3910386264324188, "2019": 0.0606246218085289, "2024": 0.3519764244556427, "2025": 0.151916041970253, "2050": 0.4041621685028076, "2078": 0.5707147121429443, "2079": 0.1358480453491211, "2091": 0.... | 6535392 | UNLABELLED Artificially synthesized short interfering RNAs (siRNAs) are widely used in functional genomics to knock down specific target genes. One ongoing challenge is to guarantee that the siRNA does not elicit off-target effects. Initial reports suggested that siRNAs were highly sequence-specific; however, subsequen... | siRNA specificity searching incorporating mismatch tolerance data. |
{"1011": 0.38574060797691345, "1039": 0.4855078160762787, "1051": 0.012615402229130268, "1999": 0.9394577741622925, "2000": 0.07068414986133575, "2004": 0.02412080205976963, "2005": 0.21922965347766876, "2007": 0.31132611632347107, "2011": 0.27712854743003845, "2029": 0.24018502235412598, "2043": 0.09672962874174118, "... | 6536598 | Chromatin structure is modulated during deoxyribonucleic acid excision repair, but how this is achieved is unclear. Loss of the yeast Ino80 chromatin-remodeling complex (Ino80-C) moderately sensitizes cells to ultraviolet (UV) light. In this paper, we show that INO80 acts in the same genetic pathway as nucleotide excis... | The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair |
{"1011": 0.19541899859905243, "1023": 0.7182208299636841, "1038": 0.15023678541183472, "1042": 0.2881702482700348, "1999": 0.006812678650021553, "2002": 0.6654226183891296, "2003": 0.07884006202220917, "2004": 0.02412080205976963, "2005": 0.06795065850019455, "2007": 0.1332872211933136, "2011": 0.25239890813827515, "20... | 6540064 | BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCSK9 inhibit... | Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans |
{"1011": 0.2990913391113281, "1044": 0.8281423449516296, "1048": 0.5729197263717651, "1052": 0.6430866718292236, "2000": 0.18816383183002472, "2002": 0.15610189735889435, "2005": 0.21214580535888672, "2007": 0.09850110858678818, "2008": 0.10379679501056671, "2011": 0.06429435312747955, "2013": 0.38441169261932373, "201... | 6544701 | We report a simple method, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors. We generated human iPSCs from multiple donors, including two putative human leukocyte antigen (HLA)-homozygous donors who match ∼20% of the Japanese populat... | A more efficient method to generate integration-free human iPS cells |
{"1009": 0.2394166737794876, "1011": 0.05970508232712746, "1040": 0.18492233753204346, "1052": 0.22001366317272186, "1054": 0.0797421783208847, "1058": 0.2034190446138382, "2001": 0.053244512528181076, "2005": 0.12728634476661682, "2007": 0.18248429894447327, "2034": 0.30989447236061096, "2039": 0.34577593207359314, "2... | 6549091 | BACKGROUND This clinical investigation was performed to compare the effects of permanent dual-chamber cardiac pacing with pharmacological therapy in patients with recurrent vasovagal syncope. METHODS AND RESULTS Patients from 14 centers were randomized to receive either a DDD pacemaker provided with rate-drop response ... | Permanent cardiac pacing versus medical treatment for the prevention of recurrent vasovagal syncope: a multicenter, randomized, controlled trial. |
{"1011": 0.2034190446138382, "1016": 0.11343330889940262, "1017": 0.48008447885513306, "1041": 0.8450632095336914, "1060": 0.6583697199821472, "1998": 0.21372433006763458, "2004": 0.07793712615966797, "2005": 0.1212492436170578, "2007": 0.4132472574710846, "2008": 0.04767346754670143, "2011": 0.3019835948944092, "2014"... | 6550579 | Epidermal growth factor receptor (EGFR) and HER3 each form heterodimers with HER2 and have independently been implicated as key coreceptors that drive HER2-amplified breast cancer. Some studies suggest a dominant role for EGFR, a notion of renewed interest given the development of dual HER2/EGFR small-molecule inhibito... | A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. |
{"1996": 0.11865071207284927, "2003": 0.15693697333335876, "2011": 0.25239890813827515, "2013": 0.49864232540130615, "2024": 0.3949938118457794, "2029": 0.1011524572968483, "2035": 0.02792670577764511, "2043": 0.28082266449928284, "2073": 0.1064341589808464, "2076": 0.43812891840934753, "2078": 0.06154331564903259, "20... | 6559201 | In the mammalian central nervous system, astrocytes are the most abundant cell type and play crucial roles in brain development and function. Astrocytes are known to be produced from multipotent neural stem cells (NSCs) at the late gestational stage during brain development, and accumulating evidence indicates that thi... | Mechanisms of astrocytogenesis in the mammalian brain. |
{"1011": 0.05417001247406006, "1038": 0.8550800085067749, "1041": 1.1115491390228271, "1048": 0.6016870141029358, "1058": 0.22626367211341858, "2002": 0.11343330889940262, "2003": 0.0354953333735466, "2004": 0.1693800985813141, "2005": 0.09406650811433792, "2007": 0.08603433519601822, "2014": 0.848413348197937, "2029":... | 6559701 | Epstein-Barr virus (EBV) infection contributes to the development of several different types of human malignancy, including Burkitt lymphoma, Hodgkin lymphoma, and nasopharyngeal carcinoma. As a herpesvirus, EBV can establish latent or lytic infection in cells. EBV-positive tumors are composed almost exclusively of cel... | Regulation of the latent-lytic switch in Epstein-Barr virus. |
{"1003": 0.18329764902591705, "1009": 0.4196864068508148, "1014": 0.043007105588912964, "1017": 0.20580662786960602, "1020": 0.2231435477733612, "1023": 0.0317181795835495, "1039": 0.2607102394104004, "1050": 0.06886265426874161, "1052": 0.36900100111961365, "1058": 0.20818853378295898, "1998": 0.040196798741817474, "2... | 6561200 | BACKGROUND Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized clinical trials. Because the vast majority of women with positive cytology are also HPV DNA positive, screening strategies that... | Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer screening. |
{"1011": 0.06520967930555344, "1018": 0.10731173306703568, "1040": 0.4487839937210083, "1043": 0.6833335757255554, "1050": 0.4950772523880005, "1996": 0.19541899859905243, "1999": 0.03925827145576477, "2004": 0.6764062643051147, "2006": 0.1332872211933136, "2008": 0.015504186972975731, "2011": 0.32270604372024536, "201... | 6565037 | At excitatory synapses on CA1 pyramidal cells of the hippocampus, a larger quantal content is sensed by N-methyl-D-aspartic acid receptors (NMDARs) than by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). A novel explanation for this discrepancy is that glutamate released from terminals pres... | Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate Uptake |
{"1011": 0.4203280806541443, "1044": 0.2493593990802765, "1048": 0.03360854089260101, "1054": 0.1889725625514984, "1055": 0.10467668622732162, "2002": 1.0257055759429932, "2003": 0.7951818704605103, "2011": 0.029824240133166313, "2022": 0.304147332906723, "2024": 0.06795065850019455, "2044": 0.4855078160762787, "2061":... | 6580081 | Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver transplantation. The pathophysiology of hepatic ischemia-reperfusion includes a number of mechanisms that contribute to various degrees in the overall injury. Some ... | Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. |
{"1011": 0.06246116757392883, "1015": 0.19381128251552582, "1016": 0.6202403903007507, "1017": 0.22782009840011597, "1021": 0.8004589080810547, "1041": 0.18654440343379974, "1042": 1.0298984050750732, "1043": 0.4041621685028076, "1047": 0.058784693479537964, "1156": 0.6358738541603088, "1998": 0.21687394380569458, "199... | 6588614 | Diabetes and associated metabolic conditions have reached pandemic proportions worldwide, and there is a clear unmet medical need for new therapies that are both effective and safe. FGF19 and FGF21 are distinctive members of the FGF family that function as endocrine hormones. Both have potent effects on normalizing glu... | Characterization of a FGF19 Variant with Altered Receptor Specificity Revealed a Central Role for FGFR1c in the Regulation of Glucose Metabolism |
{"1017": 0.15610189735889435, "2011": 0.28450319170951843, "2029": 0.16359257698059082, "2031": 0.11343330889940262, "2037": 0.09317722171545029, "2038": 0.1229778528213501, "2044": 0.04953393340110779, "2064": 0.29981520771980286, "2070": 0.1685553640127182, "2071": 0.09584271162748337, "2079": 0.0606246218085289, "20... | 6599693 | We recently selected 3 long-lived mutant strains of Saccharomyces cerevisiae by a lasting exposure to exogenous lithocholic acid. Each mutant strain can maintain the extended chronological lifespan after numerous passages in medium without lithocholic acid. In this study, we used these long-lived yeast mutants for empi... | Empirical verification of evolutionary theories of aging |
{"1011": 0.15526613593101501, "1015": 0.18167030811309814, "1017": 0.3269403576850891, "1039": 0.3346569836139679, "1996": 0.15359249711036682, "1999": 0.10993985831737518, "2003": 0.09406650811433792, "2005": 0.2969166338443756, "2008": 0.1011524572968483, "2011": 0.42416930198669434, "2026": 0.5450005531311035, "2028... | 6609935 | The Drosophila melanogaster MICAL protein is essential for the neuronal growth cone machinery that functions through plexin- and semaphorin-mediated axonal signaling. Drosophila MICAL is also involved in regulating myofilament organization and synaptic structures, and serves as an actin disassembly factor downstream of... | Differential regulation of actin microfilaments by human MICAL proteins. |
{"1011": 0.29255300760269165, "1016": 0.4926934838294983, "1017": 0.371698260307312, "1039": 0.034552380442619324, "1050": 0.6659244894981384, "1056": 0.006812678650021553, "2005": 0.4286321699619293, "2011": 0.14179791510105133, "2029": 0.06429435312747955, "2048": 0.10026945173740387, "2064": 0.2501201331615448, "209... | 6625693 | The use of N-type voltage-gated calcium channel (CaV2.2) blockers to treat pain is limited by many physiological side effects. Here we report that inflammatory and neuropathic hypersensitivity can be suppressed by inhibiting the binding of collapsin response mediator protein 2 (CRMP-2) to CaV2.2 and thereby reducing ch... | Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex |
{"1015": 0.5712664127349854, "1045": 1.1350497007369995, "1057": 0.6902132034301758, "1999": 0.0038986403960734606, "2007": 0.12642613053321838, "2011": 0.11604541540145874, "2013": 0.04113444685935974, "2015": 0.21293537318706512, "2025": 0.14349138736724854, "2028": 0.32764431834220886, "2029": 0.10203468054533005, "... | 6636088 | Deficiencies in the activity of complex I (NADH: ubiquinone oxidoreductase) are an important cause of human mitochondrial disease. Complex I is composed of at least 46 structural subunits that are encoded in both nuclear and mitochondrial DNA. Enzyme deficiency can result from either impaired catalytic efficiency or an... | Identification and characterization of a common set of complex I assembly intermediates in mitochondria from patients with complex I deficiency. |
{"1014": 0.08692999184131622, "1019": 0.2711893916130066, "1021": 0.007782140281051397, "1022": 0.21687394380569458, "1057": 0.1332872211933136, "2001": 0.04394211992621422, "2005": 0.08782484382390976, "2022": 0.12384103983640671, "2043": 0.15693697333335876, "2051": 0.9052929878234863, "2053": 0.4286321699619293, "20... | 6647414 | IMPORTANCE The 2008 Physical Activity Guidelines for Americans recommended a minimum of 75 vigorous-intensity or 150 moderate-intensity minutes per week (7.5 metabolic-equivalent hours per week) of aerobic activity for substantial health benefit and suggested additional benefits by doing more than double this amount. H... | Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. |
{"1017": 0.21922965347766876, "1019": 0.11951763927936554, "1041": 0.8957691192626953, "1043": 0.6578640341758728, "1061": 0.7665573358535767, "1999": 0.10026945173740387, "2004": 0.0842406153678894, "2005": 0.26296505331993103, "2007": 0.0842406153678894, "2011": 0.33325836062431335, "2015": 0.7067264318466187, "2024"... | 6650933 | Green tea polyphenols (GTPPs) are considered beneficial to human health, especially as chemopreventive agents. Recently, cytotoxic reactive oxygen species (ROS) were identified in tumor and certain normal cell cultures incubated with high concentrations of the most abundant GTPP, (-)-epigallocatechin-3-gallate (EGCG). ... | Green tea polyphenol causes differential oxidative environments in tumor versus normal epithelial cells. |
{"1011": 0.05417001247406006, "1043": 0.3269403576850891, "1048": 0.0797421783208847, "2011": 0.09495500475168228, "2015": 0.05139094591140747, "2029": 0.23015019297599792, "2038": 0.06154331564903259, "2042": 0.05417001247406006, "2063": 0.2247048318386078, "2069": 0.24248650670051575, "2076": 0.13243216276168823, "20... | 6669242 | Although protein acetylation is widely observed, it has been associated with few specific regulatory functions making it poorly understood. To interrogate its functionality, we analyzed the acetylome in Escherichia coli knockout mutants of cobB, the only known sirtuin-like deacetylase, and patZ, the best-known protein ... | Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coli |
{"1011": 0.013579257763922215, "1017": 0.14264501631259918, "1019": 0.3443928062915802, "1022": 0.33115679025650024, "1039": 0.4812922179698944, "1043": 0.5596157908439636, "1052": 0.5483922958374023, "1998": 0.36290550231933594, "1999": 0.04860413447022438, "2004": 0.22782009840011597, "2006": 0.09050461649894714, "20... | 6670101 | It is long been known that cancer and non-cancer cells can be distinguished on the basis of their nucleolar morphologies. As early as the 19th century, it was reported that cancer cells have larger and more irregularly shaped nucleoli. Since then, pathologists have used nucleolar morphology to predict the clinical outc... | Ribosome biogenesis: Achilles heel of cancer? |
{"2003": 0.3304552733898163, "2005": 0.319873183965683, "2011": 0.2516399025917053, "2013": 0.39696553349494934, "2043": 0.04953393340110779, "2047": 0.659380316734314, "2054": 0.0058422754518687725, "2075": 0.07341018319129944, "2076": 0.46853771805763245, "2079": 0.18654440343379974, "2099": 0.32058215141296387, "210... | 6673421 | Angiogenesis, the development of new blood vessel from pre-existing vessels, is a key process in the formation of the granulation tissue during wound healing. The appropriate development of new blood vessels, along with their subsequent maturation and differentiation, establishes the foundation for functional wound neo... | Cell and molecular mechanisms of insulin-induced angiogenesis |
{"1011": 0.18329764902591705, "1015": 0.48008447885513306, "1050": 0.8013357520103455, "1164": 0.1510767638683319, "2011": 0.4412745535373688, "2028": 0.0752234235405922, "2029": 0.14179791510105133, "2058": 0.4500300884246826, "2076": 0.06520967930555344, "2091": 0.4494072198867798, "2099": 0.2493593990802765, "2128":... | 6690087 | We addressed the regulatory function of mammalian target of rapamycin (mTOR) in the mechanism of thrombin-induced ICAM-1 gene expression in endothelial cells. Pretreatment of HUVECs with rapamycin, an inhibitor of mTOR, augmented thrombin-induced ICAM-1 expression. Inhibition of mTOR by this approach promoted whereas o... | Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells. |
{"1011": 0.0842406153678894, "1054": 0.15610189735889435, "2002": 0.4824984669685364, "2003": 0.2576959431171417, "2033": 0.46914875507354736, "2061": 0.35813871026039124, "2071": 0.08513788133859634, "2078": 1.3833603858947754, "2093": 0.2800849378108978, "2094": 0.3019835948944092, "2109": 0.0038986403960734606, "216... | 6710699 | Werner syndrome (WRN) is an uncommon autosomal recessive disease whose phenotype includes features of premature aging, genetic instability, and an elevated risk of cancer. We used three different experimental strategies to show that WRN cellular phenotypes of limited cell division potential, DNA damage hypersensitivity... | Homologous recombination resolution defect in werner syndrome. |
{"1014": 0.33325836062431335, "1040": 0.018384648486971855, "1043": 0.2852376699447632, "1052": 0.3070250153541565, "2001": 0.11168810725212097, "2012": 0.28743788599967957, "2018": 0.0842406153678894, "2019": 0.38041436672210693, "2020": 0.0770333781838417, "2022": 0.2018241584300995, "2043": 0.14349138736724854, "204... | 6710713 | OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated with subsequent professional misconduct. DESIGN Matched case-control study. Setting Records from medical schools and the General Medical Council (GMC). PARTICIPANTS 59 doctors who had graduated from any one of... | Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study |
{"1011": 0.055094651877880096, "1015": 0.2719337046146393, "1040": 0.4450363218784332, "1042": 0.574020504951477, "1047": 0.7220231294631958, "1996": 0.23710809648036957, "1997": 0.2145126610994339, "1999": 0.1358480453491211, "2007": 0.28082266449928284, "2008": 0.07159364968538284, "2011": 0.07884006202220917, "2012"... | 6712836 | Mitochondria form intricate networks through fission and fusion events. Here, we identify mitochondrial dynamics proteins of 49 and 51 kDa (MiD49 and MiD51, respectively) anchored in the mitochondrial outer membrane. MiD49/51 form foci and rings around mitochondria similar to the fission mediator dynamin-related protei... | MiD49 and MiD51, new components of the mitochondrial fission machinery. |
{"1015": 0.672426164150238, "1017": 0.6430866718292236, "1045": 0.025073638185858727, "1998": 0.43244171142578125, "2003": 0.06703783571720123, "2005": 0.20580662786960602, "2006": 0.23324857652187347, "2008": 0.05139094591140747, "2011": 0.43938836455345154, "2024": 0.3526630103588104, "2028": 0.35334911942481995, "20... | 6717533 | Stat1 and Stat3 are latent transcriptional factors activated initially through phosphorylation on single tyrosine residues induced by cytokine and growth factor occupation of cell surface receptors. Here we show that phosphorylation on a single serine (residue 727) in each protein is also required for maximal transcrip... | Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation |
{"1009": 0.014542185701429844, "1014": 0.37974658608436584, "1039": 0.7755908370018005, "1040": 0.5483922958374023, "1052": 0.2317005842924118, "1054": 0.906871497631073, "1999": 0.05417001247406006, "2004": 0.1994270235300064, "2011": 0.00875066313892603, "2012": 0.0842406153678894, "2029": 0.10993985831737518, "2043"... | 6718824 | Suboptimal developmental environments program offspring to lifelong metabolic problems. The aim of this study was to determine the impact of protein restriction in pregnancy on maternal liver lipid metabolism at 19 days of gestation (dG) and its effect on fetal brain development. Control (C) and restricted (R) mothers ... | Protein restriction during pregnancy affects maternal liver lipid metabolism and fetal brain lipid composition in the rat. |
{"1011": 0.04394211992621422, "1020": 0.029824240133166313, "1042": 0.6563454270362854, "1155": 0.4873090982437134, "2002": 0.8525851964950562, "2004": 0.04487626627087593, "2011": 0.5404602885246277, "2015": 0.28597161173820496, "2029": 0.1693800985813141, "2039": 0.5330380201339722, "2046": 0.4093637466430664, "2066"... | 6722522 | Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregates drives the progression of neurodegenerative diseases in a prion-like manner. This phenomenon is now well described in cell and animal models and involves the release of protein aggregates into the extracellular space. F... | Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. |
{"1015": 0.26296505331993103, "1038": 0.5104349255561829, "1041": 0.401551216840744, "1048": 0.083342544734478, "1051": 0.5393219590187073, "1056": 0.37371641397476196, "2004": 0.04767346754670143, "2005": 0.055094651877880096, "2015": 0.2539152204990387, "2035": 0.7086513638496399, "2038": 0.16442140936851501, "2042":... | 6723450 | Probiotics are promoted as being beneficial to health and positive effects on the immune system have been reported. Beneficial immune effects have been attributed to several mechanisms, including stimulating T helper 1 (Th1) immunity. To explore the effects of the probiotic Bifidobacterium animalis on Th1- and Th2-medi... | Effects of Bifidobacterium animalis administered during lactation on allergic and autoimmune responses in rodents. |
{"1039": 0.2954642176628113, "1040": 0.15610189735889435, "1996": 0.15777134895324707, "2003": 0.3388410806655884, "2029": 0.055094651877880096, "2054": 0.09850110858678818, "2076": 0.33675122261047363, "2094": 1.190008521080017, "2361": 0.9348671436309814, "2377": 0.2837681770324707, "2458": 0.5370414853096008, "2529"... | 6729465 | Congenital heart disease (CHD) is a common cardiac disorder in humans. Despite many advances in the understanding of CHD and the identification of many associated genes, the fundamental etiology for the majority of cases remains unclear. The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity ... | Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases |
{"1015": 0.0019512200960889459, "1018": 0.3995884954929352, "1019": 0.4494072198867798, "1044": 0.11778303235769272, "1052": 0.053244512528181076, "1058": 0.10467668622732162, "1061": 0.9287132620811462, "2000": 0.025073638185858727, "2004": 0.11951763927936554, "2012": 0.14095009863376617, "2043": 0.11430477350950241,... | 6748318 | BACKGROUND In Spain, prophylactic vaccination against human papillomavirus (HPV) types 16 and 18 is being offered free-of-charge to one birth cohort of girls aged 11-14. Screening is opportunistic (annual/biannual) contributing to social and geographical disparities. METHODS A multi-HPV-type microsimulation model was c... | Cost-effectiveness of human papillomavirus vaccination and screening in Spain. |
{"1009": 0.41195443272590637, "1013": 0.14686977863311768, "1014": 0.49030399322509766, "1020": 0.1332872211933136, "1043": 0.7182208299636841, "1044": 0.3070250153541565, "1056": 0.7610978484153748, "1061": 0.0019512200960889459, "1999": 0.0354953333735466, "2001": 0.05046287178993225, "2005": 0.04394211992621422, "20... | 6751418 | UNLABELLED In patients with a large, multinodular goiter (> 100 g), radiation absorbed doses in the thyroid, surrounding tissues and remainder of the body were estimated after therapeutic administration of 131I(3.7 MBq or 100 microCi/g of thyroid tissue retained at 24 hr). METHODS Thermoluminescent dosimeter (TLD) meas... | Dosimetry and risk estimates of radioiodine therapy for large, multinodular goiters. |
{"1011": 0.1718502640724182, "1015": 0.2145126610994339, "1017": 0.6000806093215942, "1019": 0.5127768516540527, "1020": 0.4709797203540802, "1052": 0.6197150945663452, "1054": 0.0842406153678894, "1056": 0.6296497583389282, "1996": 0.151916041970253, "2004": 0.025073638185858727, "2005": 0.11951763927936554, "2008": 0... | 6766459 | Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and ... | RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever |
{"1056": 0.33953672647476196, "1997": 0.083342544734478, "2007": 0.18329764902591705, "2014": 0.6970458030700684, "2016": 0.06703783571720123, "2018": 0.055094651877880096, "2019": 0.16442140936851501, "2020": 0.09672962874174118, "2062": 0.23710809648036957, "2067": 0.8592242002487183, "2109": 0.08782484382390976, "21... | 6767133 | STUDY DESIGN Prospective observational cohort. OBJECTIVE To describe the baseline characteristics of patients with a diagnosis of intervertebral disc herniation who had different treatment preferences and the relationship of specific expectations with those preferences. SUMMARY OF BACKGROUND DATA Data were gathered fro... | Patient preferences and expectations for care: determinants in patients with lumbar intervertebral disc herniation. |
{"1009": 0.5685047507286072, "1011": 0.26146242022514343, "1015": 0.176772341132164, "1023": 0.29400965571403503, "1039": 0.5751199722290039, "1043": 0.3683255612850189, "1056": 0.757441520690918, "1999": 0.5116065740585327, "2004": 0.7528522610664368, "2007": 0.2749055027961731, "2011": 0.4425300657749176, "2015": 0.0... | 6767271 | Although adjuvants are critical vaccine components, their modes of action are poorly understood. In this study, we investigated the mechanisms by which the heat-killed mycobacteria in CFA promote Th17 CD4(+) T cell responses. We found that IL-17 secretion by CD4(+) T cells following CFA immunization requires MyD88 and ... | Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. |
{"1040": 0.6096806526184082, "1051": 0.3077431619167328, "2003": 0.26820653676986694, "2011": 0.11778303235769272, "2012": 0.7854343056678772, "2050": 1.2969720363616943, "2079": 1.3769737482070923, "2080": 0.06703783571720123, "2087": 0.19622190296649933, "2106": 0.06703783571720123, "2123": 0.129004567861557, "2128":... | 6776834 | Dominant optic atrophy (DOA) is a rare progressive and irreversible blinding disease which is one of the most frequent forms of hereditary optic neuropathy. DOA is mainly caused by dominant mutation in the OPA1 gene encoding a large mitochondrial GTPase with crucial roles in membrane dynamics and cell survival. Heredit... | OPA1 gene therapy prevents retinal ganglion cell loss in a Dominant Optic Atrophy mouse model |
{"1011": 0.09228714555501938, "1013": 0.1212492436170578, "1017": 0.19782574474811554, "1041": 0.058784693479537964, "1047": 0.4855078160762787, "1052": 0.5307431221008301, "1057": 0.09228714555501938, "1998": 0.0058422754518687725, "2008": 0.22859740257263184, "2024": 0.06703783571720123, "2029": 0.36967599391937256, ... | 6784372 | The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins--p21(Cip1/WAF1), p27(Kip1), and p57(Kip2)--that bind and inhibit cyclin-CDK complexes, which are key regulators of the cell cycle. CIP/KIP CKIs have additional independent functions in regulating transcription, apop... | Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. |
{"1011": 0.2026219218969345, "1015": 0.030771657824516296, "1041": 0.09672962874174118, "1045": 0.5751199722290039, "1049": 0.7898768186569214, "1056": 0.77198725938797, "1057": 0.29981520771980286, "2001": 0.02792670577764511, "2002": 0.6613984704017639, "2005": 0.1477125883102417, "2008": 0.009718249551951885, "2010"... | 6788835 | The human cytomegalovirus gene product US11 causes rapid degradation of class I major histocompatibility complex (MHCI) heavy chains by inducing their dislocation from the endoplasmic reticulum (ER) and subsequent degradation by the proteasome. This set of reactions resembles the endogenous cellular quality control pat... | Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer. |
{"1014": 0.25995752215385437, "1039": 0.00875066313892603, "1053": 0.6400018334388733, "2003": 0.045809537172317505, "2004": 0.4196864068508148, "2006": 0.18816383183002472, "2013": 0.255429208278656, "2020": 0.13071982562541962, "2022": 0.030771657824516296, "2039": 0.4330752193927765, "2044": 0.04860413447022438, "20... | 6790197 | PURPOSE To accurately identify gene expression alterations that differentiate neoplastic from normal prostate epithelium using an approach that avoids contamination by unwanted cellular components and is not compromised by acute gene expression changes associated with tumor devascularization and resulting ischemia. EXP... | Prostate cancer-associated gene expression alterations determined from needle biopsies. |
{"1011": 0.08064348995685577, "1045": 0.022212404757738113, "1050": 0.4938860833644867, "1051": 0.09584271162748337, "1053": 0.20739519596099854, "1056": 0.9798521995544434, "2003": 0.045809537172317505, "2013": 0.25845035910606384, "2029": 0.02412080205976963, "2033": 0.0038986403960734606, "2035": 0.09672962874174118... | 6793674 | Circulating trimethylamine N-oxide (TMAO), a canonical metabolite from gut flora, has been related to the risk of cardiovascular disorders. However, the association between circulating TMAO and the risk of cardiovascular events has not been quantitatively evaluated. We performed a systematic review and meta-analysis of... | Circulating trimethylamine N‐oxide and the risk of cardiovascular diseases: a systematic review and meta‐analysis of 11 prospective cohort studies |
{"1011": 0.39762192964553833, "1039": 0.04113444685935974, "1040": 0.2160874605178833, "1047": 0.804835319519043, "1051": 0.6149744987487793, "1052": 0.24401791393756866, "1999": 0.0019512200960889459, "2005": 0.20501139760017395, "2007": 0.12728634476661682, "2011": 0.3662964701652527, "2029": 0.3262358605861664, "204... | 6796297 | Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), couples angiogenesis and osteogenesis. Here, we found that platelet-derived growth factor-BB (PDGF-BB) secreted by preosteoclasts ... | PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis |
{"1038": 0.1930064558982849, "1042": 0.5450005531311035, "1054": 0.3339579105377197, "2007": 0.23402166366577148, "2008": 0.06429435312747955, "2024": 0.04207121208310127, "2026": 1.005902886390686, "2029": 0.10993985831737518, "2033": 0.8764448165893555, "2046": 0.272677481174469, "2050": 0.42608439922332764, "2057": ... | 6807122 | Activated fibroblasts are associated with many different tumors. Myofibroblasts, activated fibroblasts, and perivascular mesenchymal cells such as pericytes play a role in cancer progression. Many studies suggest that myofibroblasts facilitate tumor growth and cancer progression. The source for myofibroblasts and other... | Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. |
{"1039": 0.3177432417869568, "1042": 0.37707099318504333, "1043": 0.5186077356338501, "2003": 0.16607704758644104, "2006": 0.15526613593101501, "2012": 0.03925827145576477, "2015": 0.3963087201118469, "2029": 0.06886265426874161, "2063": 0.41065993905067444, "2070": 0.18573370575904846, "2072": 0.49864232540130615, "20... | 6812319 | Chromosomal instability (CIN) is a hallmark of tumour initiation and progression. Some genomic regions are particularly unstable under replication stress, notably common fragile sites (CFSs) whose rearrangements in tumour cells contribute to cancer development. Recent work has shown that the Fanconi anaemia (FANC) path... | ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis |
{"1011": 0.2837681770324707, "2003": 0.1751343309879303, "2004": 0.21922965347766876, "2008": 0.2026219218969345, "2015": 0.35060185194015503, "2024": 0.42735910415649414, "2029": 0.15359249711036682, "2042": 0.05046287178993225, "2046": 0.23015019297599792, "2054": 0.058784693479537964, "2064": 0.15943801403045654, "2... | 6820680 | MicroRNAs (miRNAs) are short noncoding RNAs that exert posttranscriptional gene silencing and regulate gene expression. In addition to the hundreds of conserved cellular miRNAs that have been identified, miRNAs of viral origin have been isolated and found to modulate both the viral life cycle and the cellular transcrip... | Engineered RNA viral synthesis of microRNAs. |
{"1011": 0.14939609169960022, "1022": 0.2983669638633728, "1044": 0.08692999184131622, "1047": 0.4849066734313965, "1060": 0.3982778787612915, "2008": 0.018384648486971855, "2011": 0.3897167444229126, "2015": 0.5162794589996338, "2019": 0.36086538434028625, "2024": 0.15275461971759796, "2026": 0.7445381283760071, "2029... | 6826100 | Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation. Reliably high-quality iPSC... | The developmental potential of iPSCs is greatly influenced by reprogramming factor selection. |
{"1998": 0.07612881064414978, "2000": 0.39762192964553833, "2003": 0.09317722171545029, "2005": 0.0029254043474793434, "2008": 0.013579257763922215, "2013": 0.029824240133166313, "2029": 0.22392450273036957, "2050": 0.436867892742157, "2073": 0.06520967930555344, "2094": 0.28082266449928284, "2109": 0.20102575421333313... | 6826636 | GiardiaDB (http://GiardiaDB.org) and TrichDB (http://TrichDB.org) house the genome databases for Giardia lamblia and Trichomonas vaginalis, respectively, and represent the latest additions to the EuPathDB (http://EuPathDB.org) family of functional genomic databases. GiardiaDB and TrichDB employ the same framework as ot... | GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis |
{"1011": 0.11256109178066254, "1047": 0.3903779089450836, "1052": 0.151916041970253, "1996": 0.16110190749168396, "1997": 0.23092569410800934, "1998": 0.02316705882549286, "2004": 0.3005385100841522, "2005": 0.06246116757392883, "2006": 0.07341018319129944, "2008": 0.034552380442619324, "2011": 0.304147332906723, "2015... | 6828370 | The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on their ability to compete for microRNA binding, independently of their protein-coding fun... | A coding-independent function of gene and pseudogene mRNAs regulates tumour biology |
{"1011": 0.00875066313892603, "1025": 0.0019512200960889459, "1043": 0.3588210940361023, "1051": 0.6734226942062378, "1061": 0.6212902665138245, "1996": 0.5261374711990356, "1997": 0.3127557039260864, "1999": 0.2561853528022766, "2004": 0.2561853528022766, "2005": 0.006812678650021553, "2015": 0.06795065850019455, "201... | 6836086 | Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins. Assembly of this essential organelle occurs outside the cytoplasm in an ... | Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli |
{"1017": 0.10379679501056671, "1020": 0.011650617234408855, "1038": 0.49864232540130615, "1049": 0.1751343309879303, "1056": 0.6492279767990112, "1997": 0.03266380727291107, "2000": 0.04207121208310127, "2005": 0.006812678650021553, "2028": 0.03360854089260101, "2043": 0.06612417846918106, "2051": 0.18573370575904846, ... | 6841927 | BACKGROUND The increasing prevalence of overweight and obesity underscores the need for evidence-based, easily disseminable interventions for weight management that can be delivered on a population basis. The Transtheoretical Model (TTM) offers a promising theoretical framework for multiple behavior weight management i... | Transtheoretical model-based multiple behavior intervention for weight management: effectiveness on a population basis. |
{"1052": 0.43244171142578125, "1996": 0.11778303235769272, "2003": 0.022212404757738113, "2011": 0.2105647772550583, "2024": 0.12470348179340363, "2029": 0.10203468054533005, "2048": 0.3526630103588104, "2050": 0.22001366317272186, "2051": 0.32553088665008545, "2076": 0.03360854089260101, "2079": 0.3248254358768463, "2... | 6847208 | The accessory genes of Staphylococcus aureus, including those involved in pathogenesis, are controlled by a complex regulatory network that includes at least four two-component systems, one of which, agr, is a quorum sensor, an alternative sigma factor and a large set of transcription factors, including at least two of... | Autoinduction and signal transduction in the regulation of staphylococcal virulence. |
{"1011": 0.09050461649894714, "1038": 0.7426811456680298, "1996": 0.29981520771980286, "1999": 0.16110190749168396, "2008": 0.1212492436170578, "2011": 0.10203468054533005, "2012": 0.5979346632957458, "2013": 0.3423145115375519, "2026": 0.21687394380569458, "2029": 0.2145126610994339, "2039": 0.16524957120418549, "2070... | 6853699 | In atherosclerosis, the accumulation of apolipoprotein B-lipoproteins in the matrix beneath the endothelial cell layer of blood vessels leads to the recruitment of monocytes, the cells of the immune system that give rise to macrophages and dendritic cells. Macrophages derived from these recruited monocytes participate ... | Macrophages in the Pathogenesis of Atherosclerosis |
{"1011": 0.12556517124176025, "1017": 0.3777405619621277, "1041": 0.8829278349876404, "1042": 0.15777134895324707, "1061": 0.8941729068756104, "2005": 0.04953393340110779, "2007": 0.2018241584300995, "2011": 0.03266380727291107, "2028": 0.020300358533859253, "2029": 0.06520967930555344, "2057": 0.08154398202896118, "20... | 6863070 | Recently, single-molecule imaging and photocontrol have enabled superresolution optical microscopy of cellular structures beyond Abbe's diffraction limit, extending the frontier of noninvasive imaging of structures within living cells. However, live-cell superresolution imaging has been challenged by the need to image ... | Three-dimensional superresolution colocalization of intracellular protein superstructures and the cell surface in live Caulobacter crescentus. |
{"1003": 0.37371641397476196, "1017": 0.0038986403960734606, "1038": 0.5307431221008301, "1057": 0.401551216840744, "1997": 0.030771657824516296, "2015": 0.43623676896095276, "2058": 0.8323994874954224, "2111": 0.2447827309370041, "2116": 0.4487839937210083, "2120": 0.42225050926208496, "2137": 0.35334911942481995, "21... | 6876224 | Several recent publications have presented different estimates for the prevalence of overweight among youth in the United States. Prevalence estimates range from 11–24%, despite describing the same results from the third National Health and Nutrition Examination Survey (NHANES III). This paper discusses the variety and... | Overweight prevalence among youth in the United States: Why so many different numbers? |
{"1011": 0.009718249551951885, "1052": 1.1230508089065552, "2003": 0.12384103983640671, "2004": 0.10467668622732162, "2005": 0.0174254160374403, "2006": 0.2539152204990387, "2008": 0.10379679501056671, "2011": 0.1718502640724182, "2029": 0.3601844012737274, "2071": 0.175953671336174, "2076": 0.1751343309879303, "2079":... | 6896063 | p53 functions as a transcription factor involved in cell-cycle control, DNA repair, apoptosis and cellular stress responses. However, besides inducing cell growth arrest and apoptosis, p53 activation also modulates cellular senescence and organismal aging. Senescence is an irreversible cell-cycle arrest that has a cruc... | Senescence and aging: the critical roles of p53 |
{"1011": 0.13499516248703003, "1037": 0.15526613593101501, "1996": 0.24859806895256042, "1997": 0.2954642176628113, "1998": 0.32553088665008545, "1999": 0.1619328260421753, "2004": 0.4177590310573578, "2028": 0.03831886500120163, "2029": 0.23092569410800934, "2035": 0.0752234235405922, "2039": 0.02792670577764511, "205... | 6903077 | In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determined the asymmetric virion structure of bacteriophage MS2, which includes 178 copies of the coat protein, a single copy of the A-p... | Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ |
{"1015": 0.09317722171545029, "1055": 0.39696553349494934, "1999": 0.034552380442619324, "2005": 0.006812678650021553, "2008": 0.04953393340110779, "2011": 0.034552380442619324, "2012": 0.20660123229026794, "2013": 0.34023189544677734, "2015": 0.1734936386346817, "2029": 0.17759032547473907, "2038": 0.06337817758321762... | 6910577 | Recently, it has become possible to mobilize the Tc1/mariner transposon, Sleeping Beauty (SB), in mouse somatic cells at frequencies high enough to induce cancer. Tumours result from SB insertional mutagenesis of cancer genes, thus facilitating the identification of the genes and signalling pathways that drive tumour f... | Harnessing transposons for cancer gene discovery |
{"1009": 0.6970458030700684, "1011": 0.0770333781838417, "1017": 0.32129061222076416, "1021": 0.1685553640127182, "1056": 0.8247235417366028, "2005": 0.05970508232712746, "2011": 0.567397952079773, "2029": 0.05694137513637543, "2033": 0.3743882179260254, "2064": 0.23092569410800934, "2076": 0.0019512200960889459, "2079... | 6913227 | Foxp3(+) T regulatory (Treg) cells prevent inflammatory disease but the mechanistic basis of suppression is not understood completely. Gene silencing by RNA interference can act in a cell-autonomous and non-cell-autonomous manner, providing mechanisms of intercellular regulation. Here, we demonstrate that non-cell-auto... | MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells |
{"1020": 0.17431432008743286, "1996": 0.08871890604496002, "2003": 0.29255300760269165, "2034": 0.41195443272590637, "2054": 0.029824240133166313, "2080": 0.3170322775840759, "2109": 0.3982778787612915, "2116": 0.12986256182193756, "2129": 0.39762192964553833, "2155": 0.5618454217910767, "2166": 0.19220098853111267, "2... | 6917133 | Purpose: The REVEAL study is a randomized, controlled study of the psychological and behavioral impact of APOE disclosure in a risk assessment protocol provided to first degree relatives of patients with Alzheimer’s disease. The protocol presents risk information as cumulative incidence curves. This article describes h... | Estimating risk curves for first-degree relatives of patients with Alzheimer’s disease: The REVEAL study |
{"1039": 0.053244512528181076, "1042": 0.259204238653183, "1044": 0.055094651877880096, "1048": 0.08692999184131622, "1051": 0.3283478021621704, "1052": 0.8949713706970215, "2006": 0.29619070887565613, "2007": 0.2852376699447632, "2011": 0.24554696679115295, "2012": 0.2674594223499298, "2020": 0.02412080205976963, "202... | 6923795 | Cytochrome P450 (P450)-dependent metabolites of arachidonic acid, the epoxyeicosatrienoic acids (EETs), are proposed to be endothelium-derived hyperpolarizing factors (EDHF) that affect vascular tone; however, the effects of EDHF on endothelial-derived nitric oxide biosynthesis remain unknown. We examined the regulatio... | Up-regulation of endothelial nitric-oxide synthase by endothelium-derived hyperpolarizing factor involves mitogen-activated protein kinase and protein kinase C signaling pathways. |
{"1016": 0.11343330889940262, "1041": 0.8247235417366028, "1052": 0.1229778528213501, "2003": 0.18816383183002472, "2005": 0.007782140281051397, "2011": 0.3346569836139679, "2029": 0.3325583338737488, "2033": 0.20102575421333313, "2043": 0.09317722171545029, "2063": 1.2210142612457275, "2075": 0.28597161173820496, "207... | 6923961 | Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tu... | Prostaglandin E2 promotes intestinal tumor growth via DNA methylation |
{"1011": 0.19622190296649933, "1015": 0.6275664567947388, "1039": 0.2659635543823242, "1042": 0.42735910415649414, "1050": 0.6679295301437378, "1052": 0.34370049834251404, "1056": 0.890972912311554, "1164": 0.055094651877880096, "2007": 0.1477125883102417, "2011": 0.2493593990802765, "2028": 0.17922431230545044, "2029"... | 6936141 | The HIV-1 protein Nef enhances viral pathogenicity and accelerates disease progression in vivo. Nef potentiates T cell activation by an unknown mechanism, probably by optimizing the intracellular environment for HIV replication. Using a new T cell reporter system, we have found that Nef more than doubles the number of ... | Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. |
{"1011": 0.15442965924739838, "1056": 1.2238903045654297, "2004": 0.4531385898590088, "2005": 0.10291612148284912, "2033": 0.11256109178066254, "2063": 0.32553088665008545, "2064": 0.1485546976327896, "2075": 0.011650617234408855, "2076": 0.35334911942481995, "2079": 0.12986256182193756, "2084": 0.11865071207284927, "2... | 6944800 | Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurren... | Microenvironmental regulation of tumor progression and metastasis |
{"1014": 0.4950772523880005, "2005": 0.040196798741817474, "2022": 1.1708117723464966, "2038": 0.03360854089260101, "2042": 0.053244512528181076, "2050": 0.0009760859538801014, "2053": 0.22392450273036957, "2064": 0.13925230503082275, "2086": 0.46608972549438477, "2089": 0.12384103983640671, "2095": 0.10467668622732162... | 6945285 | OBJECTIVE To assess the effect of bezafibrate on the risk of coronary heart disease and stroke in men with lower extremity arterial disease. DESIGN Double blind placebo controlled randomised trial. SETTING 85 general practices and nine hospital vascular clinics. PARTICIPANTS 1568 men, mean age 68.2 years (range 35 to 9... | Bezafibrate in men with lower extremity arterial disease: randomised controlled trial. |
{"1003": 0.1064341589808464, "1017": 0.09050461649894714, "1019": 0.1510767638683319, "1022": 0.16442140936851501, "1023": 0.12814582884311676, "1047": 0.6291293501853943, "1049": 0.05970508232712746, "1052": 0.7124901413917542, "1999": 0.06703783571720123, "2004": 0.0797421783208847, "2007": 0.27712854743003845, "2011... | 6945691 | Prostaglandins (PGs) have been implicated as a regulator of tumor growth in mice and humans. Since natural killer cell (NK) cytotoxicity may be an important component of immune surveillance against cancer, it is appropriate to study whether the amount of PGs produced by tumors may be sufficient to suppress NK activity.... | The modulation of human natural killer cell activity by prostaglandins. |
{"1009": 0.022212404757738113, "1011": 0.4412745535373688, "1015": 0.6482070088386536, "1020": 0.10379679501056671, "1021": 0.1011524572968483, "1038": 0.12642613053321838, "1041": 0.15359249711036682, "1042": 0.5696102976799011, "1043": 0.2317005842924118, "1056": 0.38174858689308167, "2007": 0.010684899985790253, "20... | 6947286 | Recent biological studies indicate the importance of anterior-pharynx defective-1 (APH-1) proteins in Alzheimer's disease (AD) pathogenesis. We scanned APH-1 genes for the presence of sequence variations by denaturing high performance liquid chromatography and analyzed their distribution in an Italian sample of 113 AD ... | Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease. |
{"1011": 0.09584271162748337, "1017": 0.1873544454574585, "1043": 0.9576126337051392, "1048": 0.5707147121429443, "1060": 0.5139457583427429, "1061": 0.6867793202400208, "2005": 0.04113444685935974, "2006": 0.46117570996284485, "2010": 0.757441520690918, "2011": 0.21922965347766876, "2012": 0.02412080205976963, "2026":... | 6948886 | The available evidence suggests that the lethality of glioblastoma is driven by small subpopulations of cells that self-renew and exhibit tumorigenicity. It remains unclear whether tumorigenicity exists as a static property of a few cells or as a dynamically acquired property. We used tumor-sphere and xenograft formati... | Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression. |
{"1011": 0.12728634476661682, "1016": 0.01934296265244484, "1021": 0.28670501708984375, "1036": 0.609149694442749, "1049": 0.2749055027961731, "1158": 0.3163207769393921, "1162": 0.07250232994556427, "1997": 0.09938567131757736, "2003": 0.0752234235405922, "2014": 0.013579257763922215, "2034": 0.1873544454574585, "2045... | 6955746 | Integrating information across sensory domains to construct a unified representation of multi-sensory signals is a fundamental characteristic of perception in ecological contexts. One provocative hypothesis deriving from neurophysiology suggests that there exists early and direct cross-modal phase modulation. We provid... | Auditory Cortex Tracks Both Auditory and Visual Stimulus Dynamics Using Low-Frequency Neuronal Phase Modulation |
{"1011": 0.15693697333335876, "1043": 0.2711893916130066, "1051": 0.7018978595733643, "1054": 0.3019835948944092, "1998": 0.21530038118362427, "2003": 0.12642613053321838, "2010": 0.4132472574710846, "2034": 0.12986256182193756, "2035": 0.14433705806732178, "2060": 0.24171993136405945, "2064": 0.32270604372024536, "207... | 6957332 | Gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) occur frequently during the first months of life. Gastro-oesophageal reflux may be a primary gastro-intestinal motility disorder, but it may also be secondary to other conditions such as cow's milk protein allergy. Objective diagnosis can be d... | The diagnosis and management of gastro-oesophageal reflux in infants. |
{"1011": 0.040196798741817474, "1054": 0.07793712615966797, "1056": 1.1994705200195312, "1998": 0.07431721687316895, "2006": 0.19220098853111267, "2012": 0.21687394380569458, "2029": 0.2763880789279938, "2031": 0.3177432417869568, "2038": 0.12556517124176025, "2058": 0.0058422754518687725, "2062": 0.5387523174285889, "... | 6961811 | Although memory T cells respond more vigorously to stimulation and they are more sensitive to low doses of antigen than naive T cells, the molecular basis of this increased sensitivity remains unclear. We have previously shown that the T cell receptor (TCR) exists as different-sized oligomers on the surface of resting ... | Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes. |
{"1004": 0.28963330388069153, "1008": 1.0193830728530884, "1009": 0.22937409579753876, "1011": 0.04767346754670143, "1017": 0.8583967685699463, "1042": 0.35813871026039124, "1043": 1.3160102367401123, "1052": 0.04953393340110779, "1056": 0.3588210940361023, "1062": 0.6410312056541443, "2001": 0.1677299439907074, "2003"... | 6962472 | G*Power (Erdfelder, Faul, & Buchner, 1996) was designed as a general stand-alone power analysis program for statistical tests commonly used in social and behavioral research. G*Power 3 is a major extension of, and improvement over, the previous versions. It runs on widely used computer platforms (i.e., Windows XP, Wind... | G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. |
{"1011": 0.19381128251552582, "1015": 0.0913962796330452, "1042": 0.41840189695358276, "1999": 0.953857421875, "2003": 0.0317181795835495, "2004": 0.34577593207359314, "2008": 0.04767346754670143, "2011": 0.3409265875816345, "2012": 0.09584271162748337, "2024": 0.0842406153678894, "2048": 0.129004567861557, "2050": 0.1... | 6969753 | Metastatic tumor cells that actively migrate and invade surrounding tissues rely on invadopodia to degrade extracellular matrix (ECM) barriers. Invadopodia are membrane protrusions that localize enzymes required for ECM degradation. Little is known about the formation, function, and regulation of invadopodia. Here, we ... | Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. |
{"1011": 0.5347557663917542, "1013": 0.25088030099868774, "1023": 0.38308101892471313, "1037": 0.016465263441205025, "1052": 0.2830325961112976, "1054": 0.8592242002487183, "1997": 0.2493593990802765, "2000": 0.09495500475168228, "2004": 0.07341018319129944, "2005": 0.034552380442619324, "2006": 0.3588210940361023, "20... | 6974477 | In the context of the renewed interest of peptides as therapeutics, it is important to have an on-line resource for 3D structure prediction of peptides with well-defined structures in aqueous solution. We present an updated version of PEP-FOLD allowing the treatment of both linear and disulphide bonded cyclic peptides ... | PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides |
{"1011": 0.2652147710323334, "1017": 0.3930181860923767, "1021": 0.5063233375549316, "1036": 0.42735910415649414, "1041": 0.6970458030700684, "1043": 0.272677481174469, "1045": 0.16276304423809052, "1056": 0.35813871026039124, "1162": 0.35060185194015503, "2000": 0.2881702482700348, "2014": 0.04953393340110779, "2029":... | 6985854 | Speech stimuli give rise to neural activity in the listener that can be observed as waveforms using magnetoencephalography. Although waveforms vary greatly from trial to trial due to activity unrelated to the stimulus, it has been demonstrated that spoken sentences can be discriminated based on theta-band (3-7 Hz) phas... | Discrimination of speech stimuli based on neuronal response phase patterns depends on acoustics but not comprehension. |
{"1014": 0.026976587250828743, "1015": 0.12384103983640671, "1020": 0.13499516248703003, "1021": 0.011650617234408855, "1022": 0.1485546976327896, "1040": 0.45623743534088135, "1044": 0.8567397594451904, "1051": 0.18654440343379974, "1052": 0.7969439625740051, "1998": 0.025073638185858727, "2007": 0.319873183965683, "2... | 6993046 | Exertional fatigue and dyspnoea limit the daily activities of patients with pulmonary arterial hypertension 1. These symptoms are usually explained by the inability of the overloaded right ventricle to perfuse the lungs and to adapt systemic oxygen delivery to oxygen demand. Accordingly, pulmonary hypertension patients... | Breathing more with weaker respiratory muscles in pulmonary arterial hypertension. |
{"1011": 0.05139094591140747, "1038": 0.47827014327049255, "1044": 0.1384023278951645, "1155": 0.2447827309370041, "1999": 0.08782484382390976, "2002": 0.9980146884918213, "2006": 0.11081436276435852, "2029": 0.08513788133859634, "2039": 0.25694093108177185, "2050": 0.11951763927936554, "2076": 0.06246116757392883, "21... | 7005276 | The effect of acetic acid on hepatic lipid metabolism in ruminants differs significantly from that in monogastric animals. Therefore, the aim of this study was to investigate the regulation mechanism of acetic acid on the hepatic lipid metabolism in dairy cows. The AMP-activated protein kinase (AMPK) signaling pathway ... | Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes |
{"1020": 0.09228714555501938, "1021": 0.31204116344451904, "1022": 0.05046287178993225, "1023": 0.17431432008743286, "1044": 0.5838727951049805, "1997": 0.07341018319129944, "1999": 0.255429208278656, "2001": 0.04394211992621422, "2004": 0.1693800985813141, "2007": 0.24325250089168549, "2025": 0.04487626627087593, "204... | 7011850 | OBJECTIVE To examine the traditional view that unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation in insulin dependent diabetes mellitus are manifestations of autonomic neuropathy. DESIGN Perspective assessment of unawareness of hypoglycaemia and detailed assessment of autonomic neuropathy in p... | Unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation: no causal relation with diabetic autonomic neuropathy. |
{"1011": 0.19862671196460724, "1039": 0.9485763907432556, "1041": 0.12728634476661682, "1043": 0.46486347913742065, "1048": 0.6833335757255554, "1056": 0.48670899868011475, "1999": 0.012615402229130268, "2007": 0.026976587250828743, "2008": 0.0174254160374403, "2029": 0.1946154683828354, "2042": 0.037378571927547455, "... | 7020505 | Chromosomal abnormalities in chronic lymphocytic leukemia (CLL) are detected in up to 80% of patients. Among them, deletions of 11q, 13q, 17p, and trisomy 12 have a known prognostic value and play an important role in CLL pathogenesis and evolution, determining patients outcome and therapeutic strategies. Standard meth... | Genetic Abnormalities in Chronic Lymphocytic Leukemia: Where We Are and Where We Go |
{"1041": 1.1185935735702515, "1043": 0.7124901413917542, "2003": 0.19541899859905243, "2011": 0.15777134895324707, "2029": 0.1401015669107437, "2071": 0.010684899985790253, "2099": 1.245482087135315, "2124": 0.08603433519601822, "2168": 0.1619328260421753, "2179": 0.11604541540145874, "2213": 0.6394867897033691, "2240"... | 7028976 | Epidermal growth factor receptor (EGFR) is a known diagnostic and, although controversial, prognostic marker of human glioblastoma multiforme (GBM). However, its functional role and biological significance in GBM remain elusive. Here, we show that multiple GBM cell subpopulations could be purified from the specimens of... | Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis. |
{"1011": 0.14518201351165771, "1015": 0.011650617234408855, "1045": 0.176772341132164, "1999": 0.5404602885246277, "2000": 0.11430477350950241, "2005": 0.1619328260421753, "2006": 0.10906458646059036, "2008": 0.00875066313892603, "2011": 0.28743788599967957, "2015": 0.014542185701429844, "2028": 0.009718249551951885, "... | 7029990 | One type of RNA editing involves the conversion of adenosine residues into inosine in double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR). A-to-I RNA editing of the coding sequence could result in synthesis of proteins not directly encoded in the genome. ADAR edits also non-coding sequen... | Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. |
{"1011": 0.037378571927547455, "1016": 0.15275461971759796, "1017": 0.18329764902591705, "1018": 0.2561853528022766, "1019": 0.10026945173740387, "1020": 0.34577593207359314, "1040": 0.32905077934265137, "1041": 0.28670501708984375, "1051": 0.7482418417930603, "2000": 0.2409527748823166, "2003": 0.4002431631088257, "20... | 7034001 | Donor kidney exchange is an established method to overcome incompatibility of donor-recipient pairs (DRP). A computerized algorithm was devised to exchange donor kidney and was tested in a multicenter setting. The algorithm was made according to the consensus of participating centers. It makes all possible exchange com... | Outcome of multipair donor kidney exchange by a web-based algorithm. |
{"1009": 0.36900100111961365, "1011": 0.05139094591140747, "1016": 0.11168810725212097, "1018": 0.20102575421333313, "1021": 0.2018241584300995, "1039": 0.09584271162748337, "1048": 0.3982778787612915, "1054": 0.1677299439907074, "1058": 0.43875885009765625, "1999": 0.034552380442619324, "2004": 0.2659635543823242, "20... | 7036529 | For studying the function of specific neurons in their native circuitry, it is desired to precisely control their activity. This often requires dissection to allow accurate electrical stimulation or neurotransmitter application , and it is thus inherently difficult in live animals, especially in small model organisms. ... | Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral Responses |
{"1011": 0.05046287178993225, "1043": 0.2983669638633728, "1051": 0.5092619061470032, "1058": 0.7239188551902771, "1155": 0.24325250089168549, "2007": 0.13071982562541962, "2011": 0.07431721687316895, "2026": 1.1031591892242432, "2029": 0.2018241584300995, "2033": 0.3560888469219208, "2044": 0.09938567131757736, "2046"... | 7039855 | Myelin regeneration can occur spontaneously in demyelinating diseases such as multiple sclerosis (MS). However, the underlying mechanisms and causes of its frequent failure remain incompletely understood. Here we show, using an in-vivo remyelination model, that demyelinated axons are electrically active and generate de... | Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors |
{"1011": 0.07159364968538284, "1022": 0.29473719000816345, "1043": 0.619189441204071, "1052": 0.4437839686870575, "1053": 0.9271688461303711, "1997": 0.0058422754518687725, "2004": 0.09406650811433792, "2011": 0.17020416259765625, "2012": 0.43812891840934753, "2015": 0.0009760859538801014, "2029": 0.1358480453491211, "... | 7042304 | Studies of the mutant gene in Huntington's disease, and for eight related neurodegenerative disorders, have identified polyglutamine (polyQ) expansions as a basis for cellular toxicity. This finding has led to a disease hypothesis that protein aggregation and cellular dysfunction can occur at a threshold of approximate... | The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. |
{"1011": 0.3499138653278351, "1035": 0.05786345899105072, "1042": 0.06612417846918106, "1047": 0.3423145115375519, "1050": 1.0655186176300049, "1164": 1.0101795196533203, "1998": 0.35334911942481995, "1999": 0.13755162060260773, "2003": 0.07341018319129944, "2029": 0.27934664487838745, "2054": 0.3423145115375519, "2075... | 7046487 | Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it seem... | Inflammation meets cancer, with NF-κB as the matchmaker |
{"1006": 0.0058422754518687725, "1040": 0.4419025182723999, "1043": 0.3388410806655884, "1045": 1.1462857723236084, "1046": 0.8323994874954224, "1058": 0.7276995778083801, "1997": 0.006812678650021553, "2000": 0.11256109178066254, "2003": 0.06337817758321762, "2011": 0.20580662786960602, "2019": 0.11081436276435852, "2... | 7059897 | The variable domain of an immunoglobulin (IG) sequence is encoded by multiple genes, including the variable (V) gene, the diversity (D) gene and the joining (J) gene. Analysis of IG sequences typically requires identification of each gene, as well as a comparison of sequence variations in the context of defined regions... | IgBLAST: an immunoglobulin variable domain sequence analysis tool |
{"1011": 0.2501201331615448, "1054": 0.01934296265244484, "1998": 0.23710809648036957, "2001": 0.4500300884246826, "2015": 0.2983669638633728, "2018": 0.0038986403960734606, "2020": 0.3588210940361023, "2022": 0.07068414986133575, "2029": 0.012615402229130268, "2031": 0.1710275560617447, "2034": 0.8357921838760376, "20... | 7074001 | Psychiatrists have long recognised that routine clinical practice needs to be shaped and informed by external evidence (Lewis, 1958). Psychiatric researchers were among the first to utilise multi-centre randomised controlled trials (demonstrating the effectiveness of antipsychotics), and psychologists were among the fi... | Evidence into practice. Application of psychological models of change in evidence-based implementation. |
{"1011": 0.22937409579753876, "1039": 0.2689530849456787, "1059": 1.318103313446045, "1996": 0.034552380442619324, "1999": 0.013579257763922215, "2006": 0.0770333781838417, "2008": 0.05786345899105072, "2011": 0.12814582884311676, "2015": 0.13071982562541962, "2029": 0.2741633653640747, "2033": 0.46608972549438477, "20... | 7093809 | Secreted Wnt proteins influence neural connectivity by regulating axon guidance, dendritic morphogenesis and synapse formation. We report a new role for Wnt and Frizzled proteins in establishing the anteroposterior polarity of the mechanosensory neurons ALM and PLM in C. elegans. Disruption of Wnt signaling leads to a ... | Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans. |
{"1014": 0.2622140049934387, "1016": 0.9287132620811462, "1026": 0.0913962796330452, "1038": 0.29036402702331543, "1043": 0.5278670787811279, "1044": 0.4734157919883728, "1052": 0.21135559678077698, "1054": 0.5979346632957458, "1997": 0.026976587250828743, "2001": 0.037378571927547455, "2005": 0.1358480453491211, "2039... | 7098463 | CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. OBJECTIVE To determine if surgically induced weight loss results in better glycemic control and less need for diabetes medications than conventional approaches to weight loss and diabetes control. ... | Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. |
{"1009": 0.49030399322509766, "1014": 0.3416208028793335, "1018": 0.06154331564903259, "1039": 0.013579257763922215, "1052": 0.3409265875816345, "1056": 0.5127768516540527, "1062": 0.053244512528181076, "1998": 0.10731173306703568, "2000": 0.015504186972975731, "2007": 0.6006163358688354, "2034": 0.05694137513637543, "... | 7111021 | BACKGROUND We previously reported that integrating antiretroviral therapy (ART) with tuberculosis treatment reduces mortality. However, the timing for the initiation of ART during tuberculosis treatment remains unresolved. METHODS We conducted a three-group, open-label, randomized, controlled trial in South Africa invo... | Integration of antiretroviral therapy with tuberculosis treatment. |
{"1011": 0.02412080205976963, "1042": 0.5534584522247314, "1047": 0.6207655072212219, "1049": 0.21922965347766876, "1054": 0.6931471824645996, "1996": 0.09317722171545029, "2003": 0.14686977863311768, "2008": 0.18978065252304077, "2011": 0.28670501708984375, "2012": 0.11430477350950241, "2013": 0.07341018319129944, "20... | 7114092 | Megakaryocyte (MK) is the naturally polyploid cell that gives rise to platelets. Polyploidization occurs by endomitosis, which was a process considered to be an incomplete mitosis aborted in anaphase. Here, we used time-lapse confocal video microscopy to visualize the endomitotic process of primary human megakaryocytes... | From bloodjournal.hematologylibrary.org at PENN STATE UNIVERSITY on February 23, 2013. For personal use only. |
{"1011": 0.6543170213699341, "1015": 0.6823468804359436, "1016": 0.2478361576795578, "1018": 0.2409527748823166, "1021": 0.35745587944984436, "1023": 0.5596157908439636, "1039": 0.43938836455345154, "1041": 0.1485546976327896, "1045": 0.08692999184131622, "1056": 0.603290855884552, "1157": 0.5612884759902954, "2003": 0... | 7115651 | IL-21 is a pleiotropic type 1 cytokine that shares the common cytokine receptor γ-chain, γ(c), with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is most homologous to IL-2. These cytokines are encoded by adjacent genes, but they are functionally distinct. Whereas IL-2 promotes development of regulatory T cells and confers ... | Key role for IL-21 in experimental autoimmune uveitis. |
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