spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1007": 0.16524957120418549, "1011": 0.16690383851528168, "1019": 0.012615402229130268, "1025": 0.05139094591140747, "1047": 0.7258110046386719, "1049": 0.3949938118457794, "1052": 0.2018241584300995, "1997": 0.0174254160374403, "1999": 0.26146242022514343, "2003": 0.02887592278420925, "2004": 0.2409527748823166, "200... | 7116734 | Nicotinamide (Nam) phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in mammalian NAD synthesis, catalyzing nicotinamide mononucleotide (NMN) formation from Nam and 5-phosphoribosyl 1-pyrophosphate (PRPP). NAMPT has also been described as an adipocytokine visfatin with a variety of actions, although physiol... | Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma |
{"1011": 0.27712854743003845, "1038": 0.46486347913742065, "1039": 0.1064341589808464, "1044": 0.8796916007995605, "2002": 0.7463917136192322, "2003": 0.09406650811433792, "2004": 0.05139094591140747, "2005": 0.11604541540145874, "2007": 0.01934296265244484, "2010": 0.9546096324920654, "2011": 0.2447827309370041, "2029... | 7137057 | BACKGROUND & AIMS HBV covalently closed circular DNA (cccDNA), the replicative intermediate responsible for persistent HBV infection of hepatocytes, is the template for transcription of all viral mRNAs. Nuclear cccDNA accumulates as a stable episome organized into minichromosomes by histone and nonhistone proteins. In ... | Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. |
{"1006": 0.06977381557226181, "1011": 0.26446542143821716, "1013": 0.3910386264324188, "1015": 0.07884006202220917, "1016": 0.08603433519601822, "1043": 0.6921701431274414, "1049": 0.41065993905067444, "1054": 0.7370892763137817, "1055": 0.34370049834251404, "1057": 0.35745587944984436, "1999": 0.018384648486971855, "2... | 7142113 | Fucci technology makes possible the distinction between live cells in the G(1) and S/G(2)/M phases by dual-color imaging. This technology relies upon ubiquitylation-mediated proteolysis, and transgenic mice expressing Fucci provide a powerful model system with which to study the coordination of the cell cycle and devel... | Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter. |
{"1009": 0.27712854743003845, "1011": 0.15442965924739838, "1020": 0.8592242002487183, "1052": 0.5209306478500366, "1055": 0.43875885009765625, "1056": 1.0841858386993408, "1058": 0.04113444685935974, "1996": 0.17020416259765625, "2003": 0.23864774405956268, "2007": 0.0174254160374403, "2008": 0.05694137513637543, "201... | 7145763 | The bacterial type VI secretion system (T6SS) is a dynamic organelle that bacteria use to target prey cells for inhibition via translocation of effector proteins. Time-lapse fluorescence microscopy has documented striking dynamics of opposed T6SS organelles in adjacent sister cells of Pseudomonas aeruginosa. Such cell-... | Tit-for-Tat: Type VI Secretion System Counterattack during Bacterial Cell-Cell Interactions |
{"1016": 0.5860490798950195, "1040": 0.02412080205976963, "1042": 1.0560526847839355, "1043": 0.2478361576795578, "1048": 0.9878844022750854, "1997": 0.14602625370025635, "2003": 0.23402166366577148, "2005": 0.3903779089450836, "2012": 0.0019512200960889459, "2029": 0.18411032855510712, "2048": 0.12728634476661682, "21... | 7150238 | Fibroblast growth factor 21 (FGF21) is a recently discovered metabolic regulator. Exogenous FGF21 produces beneficial metabolic effects in animal models; however, the translation of these observations to humans has not been tested. Here, we studied the effects of LY2405319 (LY), a variant of FGF21, in a randomized, pla... | The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. |
{"1011": 0.20580662786960602, "1038": 0.3141832649707794, "1040": 0.17431432008743286, "1054": 0.1332872211933136, "2005": 0.05046287178993225, "2008": 0.06520967930555344, "2011": 0.23479416966438293, "2029": 0.18004031479358673, "2043": 0.19541899859905243, "2048": 0.34370049834251404, "2050": 0.6374238729476929, "20... | 7151961 | Double-strand breaks (DSBs) occur frequently during DNA replication. They are also caused by ionizing radiation, chemical damage or as part of the series of programmed events that occur during meiosis. In yeast, DSB repair requires RAD52, a protein that plays a critical role in homologous recombination. Here we describ... | Visualization of recombination intermediates produced by RAD52-mediated single-strand annealing. |
{"1011": 0.2018241584300995, "1015": 0.11168810725212097, "1038": 0.1685553640127182, "1042": 0.10291612148284912, "1155": 0.3443928062915802, "1157": 0.5472630262374878, "1998": 0.022212404757738113, "1999": 0.15610189735889435, "2003": 0.2160874605178833, "2005": 0.23633737862110138, "2007": 0.03831886500120163, "201... | 7155555 | Listeria monocytogenes is widely used as a model to study immune responses against intracellular bacteria. It has been shown that neutrophils and macrophages play an important role to restrict bacterial replication in the early phase of primary infection in mice, and that the cytokines interferon-γ (IFN-γ) and tumor ne... | Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis |
{"1043": 0.5557019114494324, "1051": 0.3269403576850891, "1996": 0.42926809191703796, "1999": 0.07884006202220917, "2011": 0.34715715050697327, "2029": 0.0174254160374403, "2044": 0.28670501708984375, "2046": 0.27342069149017334, "2047": 0.9147270321846008, "2064": 0.306306391954422, "2065": 0.06612417846918106, "2073"... | 7157436 | In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease. Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of... | Neuronal replacement from endogenous precursors in the adult brain after stroke |
{"1014": 0.0029254043474793434, "1015": 0.4531385898590088, "1038": 1.1456648111343384, "1043": 0.12384103983640671, "2005": 0.07250232994556427, "2011": 0.07250232994556427, "2028": 0.13157635927200317, "2029": 0.0606246218085289, "2033": 0.22626367211341858, "2058": 0.5893046259880066, "2084": 0.33605360984802246, "2... | 7165938 | PURPOSE The circadian clock gene Bmal1 is involved in cancer cell proliferation and DNA damage sensitivity. The aim of this study was to explore the effect of Bmal1 on oxaliplatin sensitivity and to determine its clinical significance in colorectal cancer. EXPERIMENTAL DESIGN Three colorectal cancer cell lines, HCT116,... | Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin in colorectal cancer. |
{"1015": 0.6892333030700684, "1022": 0.2231435477733612, "1038": 0.06246116757392883, "1039": 0.7047978043556213, "1043": 0.7009293437004089, "2001": 0.007782140281051397, "2004": 0.6482070088386536, "2005": 0.036437395960092545, "2011": 0.09672962874174118, "2012": 0.01934296265244484, "2020": 0.05786345899105072, "20... | 7177329 | Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have been unsuccessful, a minority of individuals naturally develop these antibodies after many years of infection. How such antibodies arise, ... | Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape |
{"1016": 0.10993985831737518, "1042": 0.5707147121429443, "1998": 0.020300358533859253, "2005": 0.010684899985790253, "2007": 0.1212492436170578, "2011": 0.08692999184131622, "2033": 0.36494144797325134, "2058": 0.3443928062915802, "2063": 0.2516399025917053, "2064": 0.0913962796330452, "2079": 0.34023189544677734, "20... | 7185591 | Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent pathway responsible for a majority of the longevity benefit associated with... | Sir2-Independent Life Span Extension by Calorie Restriction in Yeast |
{"1014": 0.469759464263916, "1020": 0.0009760859538801014, "1026": 0.27934664487838745, "1052": 0.680370569229126, "1999": 0.16690383851528168, "2006": 0.08244366943836212, "2011": 0.08961215615272522, "2029": 0.13670019805431366, "2044": 0.8925741910934448, "2046": 0.22626367211341858, "2076": 0.28670501708984375, "20... | 7198295 | The aim of the study was to determine the effect of single whole-body cryotherapy (WBC) session applied prior to submaximal exercise on the activity of antioxidant enzymes, the concentration of lipid peroxidation products, total oxidative status, and the level of cytokines in blood of volleyball players. The study grou... | The Effect of Submaximal Exercise Preceded by Single Whole-Body Cryotherapy on the Markers of Oxidative Stress and Inflammation in Blood of Volleyball Players |
{"2001": 0.1358480453491211, "2012": 0.07431721687316895, "2020": 0.03925827145576477, "2042": 0.3615458607673645, "2043": 0.3012613356113434, "2051": 0.4126010537147522, "2075": 0.00875066313892603, "2076": 0.28890204429626465, "2086": 0.3750596046447754, "2095": 0.3325583338737488, "2105": 0.052318159490823746, "2106... | 7209559 | CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time of a transient deficit in cortical bone mass due to the increased calcium demand during maximal skeletal growth. Changes in physical activity or diet... | Incidence of childhood distal forearm fractures over 30 years: a population-based study. |
{"1011": 0.2034190446138382, "1018": 0.0317181795835495, "2025": 0.034552380442619324, "2048": 0.05139094591140747, "2057": 0.11517547070980072, "2058": 0.29473719000816345, "2078": 0.8074519634246826, "2079": 0.31560876965522766, "2109": 0.2800849378108978, "2128": 0.6533012986183167, "2166": 0.06612417846918106, "217... | 7211056 | UNLABELLED The contribution of whole-genome doubling to chromosomal instability (CIN) and tumor evolution is unclear. We use long-term culture of isogenic tetraploid cells from a stable diploid colon cancer progenitor to investigate how a genome-doubling event affects genome stability over time. Rare cells that survive... | Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. |
{"1011": 0.06246116757392883, "1037": 0.056018441915512085, "1039": 0.27342069149017334, "1055": 0.23556606471538544, "1158": 0.2689530849456787, "1999": 0.0174254160374403, "2003": 0.15359249711036682, "2004": 0.010684899985790253, "2005": 0.04394211992621422, "2008": 0.18492233753204346, "2029": 0.25467249751091003, ... | 7221410 | The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that regulates innate immunity but has no known functions in the brain. We have previously shown that the CD33 gene is a risk factor for Alzheimer's disease (AD). Here, we observed increased expression of CD33 in microglial cells in AD b... | Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta |
{"1011": 0.22626367211341858, "1020": 0.6112717390060425, "1054": 0.512191891670227, "1999": 0.018384648486971855, "2002": 0.7827593088150024, "2006": 0.01934296265244484, "2007": 0.29328158497810364, "2011": 0.21530038118362427, "2029": 0.29400965571403503, "2039": 0.12814582884311676, "2050": 0.02887592278420925, "20... | 7223604 | To study the effector function of the ADP- ribosylation factor (ARF) 6 GTP-binding protein, we transfected HeLa cells with wild-type, epitope-tagged ARF6. Previously shown to indirectly activate the ARF1 GTPase, aluminum fluoride (AIF) treatment of ARF6-transfected cells resulted in a redistribution of both ARF6 and ac... | Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase |
{"1011": 0.026976587250828743, "1014": 0.07068414986133575, "1016": 0.12556517124176025, "1050": 0.13755162060260773, "1051": 0.4248080551624298, "1052": 0.2800849378108978, "1056": 0.18978065252304077, "1059": 0.5318912267684937, "1998": 0.10467668622732162, "2004": 0.2719337046146393, "2019": 0.3601844012737274, "204... | 7224632 | The extent of structural injury in sports-related concussion (SRC) is central to the course of recovery, long-term effects, and the decision to return to play. In the present longitudinal study, we used diffusion tensor imaging (DTI) to assess white matter (WM) fiber tract integrity within 2 days, 2 weeks, and 2 months... | A longitudinal diffusion tensor imaging study assessing white matter fiber tracts after sports-related concussion. |
{"1009": 0.8161250352859497, "1018": 0.2105647772550583, "1039": 0.2990913391113281, "1048": 0.33325836062431335, "1056": 0.4891071021556854, "2003": 0.07341018319129944, "2011": 0.3910386264324188, "2013": 0.11778303235769272, "2029": 0.009718249551951885, "2038": 0.026025565341114998, "2042": 0.030771657824516296, "2... | 7224723 | HIV causes a chronic infection characterized by depletion of CD4(+) T lymphocytes and the development of opportunistic infections. Despite drugs that inhibit viral spread, HIV infection has been difficult to cure because of uncharacterized reservoirs of infected cells that are resistant to highly active antiretroviral ... | HIV–1 Infects Multipotent Progenitor Cells Causing Cell Death and Establishing Latent Cellular Reservoirs |
{"1011": 0.23479416966438293, "1044": 0.5318912267684937, "1045": 0.3883931338787079, "1052": 0.8845420479774475, "1054": 0.24401791393756866, "1057": 0.5186077356338501, "2008": 0.0913962796330452, "2029": 0.39696553349494934, "2043": 0.0770333781838417, "2057": 0.6265231370925903, "2076": 0.2659635543823242, "2083": ... | 7225911 | It is well known that upon stress, the level of the tumor suppressor p53 is remarkably elevated. However, despite extensive studies, the underlying mechanism involving important inter-players for stress-induced p53 regulation is still not fully understood. We present evidence that the human lincRNA-RoR (RoR) is a stron... | The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage |
{"1006": 0.22157983481884003, "1011": 0.026976587250828743, "1013": 0.5045560002326965, "1018": 0.014542185701429844, "1044": 0.06337817758321762, "1048": 0.841701865196228, "1052": 1.1141164302825928, "1054": 0.6980181336402893, "1997": 0.043007105588912964, "1998": 0.5220900774002075, "1999": 0.3283478021621704, "200... | 7227763 | The increase in lactate (L) and pyruvate (P) content of arterial blood during experimental and clinical shock states and the extent to which such increases serve as measures of oxygen deficit and irreversible injury were investigated on an empirical basis. A standardized method for production of hemorrhagic shock in th... | Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). |
{"1011": 0.03360854089260101, "1040": 0.3824150264263153, "1052": 0.5116065740585327, "2003": 0.10818854719400406, "2048": 0.3750596046447754, "2050": 0.20818853378295898, "2066": 0.25088030099868774, "2086": 0.22079704701900482, "2109": 0.46117570996284485, "2146": 0.41195443272590637, "2166": 0.4574742913246155, "219... | 7228140 | Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes capturing precise tumor-specific molecular information difficult. Here we have overcome this problem by applying blind source separation to a diverse c... | Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma |
{"1016": 0.20977331697940826, "1041": 0.2447827309370041, "1050": 0.13499516248703003, "1051": 0.14518201351165771, "1996": 0.045809537172317505, "1997": 0.040196798741817474, "1999": 0.9147270321846008, "2005": 0.02316705882549286, "2007": 0.24859806895256042, "2008": 0.04767346754670143, "2011": 0.3077431619167328, "... | 7230315 | The high-output pathway of nitric oxide production helps protect mice from infection by several pathogens, including Mycobacterium tuberculosis. However, based on studies of cells cultured from blood, it is controversial whether human mononuclear phagocytes can express the corresponding inducible nitric oxide synthase ... | Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis |
{"1040": 0.4518963396549225, "2005": 0.33115679025650024, "2007": 0.3304552733898163, "2008": 0.06703783571720123, "2015": 0.30558720231056213, "2029": 0.01934296265244484, "2047": 0.09406650811433792, "2054": 0.014542185701429844, "2064": 0.06977381557226181, "2079": 0.06337817758321762, "2091": 1.3118107318878174, "2... | 7239105 | Remarkable advances have been made in recent years towards therapeutics for cognitive impairment in individuals with Down syndrome (DS) by using mouse models. In this review, we briefly describe the phenotypes of mouse models that represent outcome targets for drug testing, the behavioral tests used to assess impairmen... | The use of mouse models to understand and improve cognitive deficits in Down syndrome |
{"1011": 0.20660123229026794, "1049": 0.04767346754670143, "1997": 0.043007105588912964, "2000": 0.38174858689308167, "2003": 0.052318159490823746, "2005": 0.25467249751091003, "2012": 0.20102575421333313, "2022": 0.0029254043474793434, "2034": 0.045809537172317505, "2039": 0.1970241367816925, "2047": 0.207395195960998... | 7260461 | The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved for the alignment of divergent protein sequences. Firstly, individual weights are assigned to each sequence in a partial alignment in order to down-weight near-duplicate sequences and up-weight the most diverge... | position-specific gap penalties |
{"1043": 0.26296505331993103, "1997": 0.011650617234408855, "2000": 0.18248429894447327, "2005": 0.04487626627087593, "2029": 0.040196798741817474, "2034": 0.32553088665008545, "2041": 0.08064348995685577, "2046": 0.16524957120418549, "2048": 0.3903779089450836, "2050": 0.11430477350950241, "2051": 0.040196798741817474... | 7261402 | We describe algorithms for detecting pedestrians in videos acquired by infrared (and color) sensors. Two approaches are proposed based on gait. The first employs computationally efficient periodicity measurements. Unlike other methods, it estimates a periodic motion frequency using two cascading hypothesis testing step... | Pedestrian Detection via Periodic Motion Analysis |
{"1017": 0.0913962796330452, "1042": 0.9394577741622925, "1048": 0.010684899985790253, "1052": 0.5267143249511719, "1055": 0.030771657824516296, "1058": 0.14939609169960022, "1998": 0.04953393340110779, "1999": 0.09317722171545029, "2001": 0.15610189735889435, "2007": 0.12384103983640671, "2013": 0.45623743534088135, "... | 7264949 | In order to investigate the prevalence of infections with three feline retroviruses feline immunodeficiency virus (FIV), feline leukemia virus (FeLV) and feline syncytial virus (FSV) in Taiwan, we collected a total of 75 blood samples from cats from veterinary hospitals, a breeding cattery and a homeless shelter in 199... | Seroepidemiological survey of feline retrovirus infections in cats in Taiwan in 1993 and 1994. |
{"1996": 0.2749055027961731, "2011": 0.4450363218784332, "2015": 0.0913962796330452, "2029": 0.25845035910606384, "2046": 0.034552380442619324, "2076": 0.33675122261047363, "2079": 0.2018241584300995, "2129": 0.11168810725212097, "2207": 0.7408206462860107, "2350": 0.6327666640281677, "2364": 0.09228714555501938, "2367... | 7268522 | The proteolytic cleavages elicited by activation of the Notch receptor release an intracellular fragment, Notch intracellular domain, which enters the nucleus to activate the transcription of targets. Changes in transcription are therefore a major output of this pathway. However, the Notch outputs clearly differ from c... | Notch targets and their regulation. |
{"1011": 0.10906458646059036, "1997": 0.08603433519601822, "2000": 0.24248650670051575, "2003": 0.022212404757738113, "2005": 0.037378571927547455, "2034": 0.40871503949165344, "2047": 0.026976587250828743, "2051": 0.7370892763137817, "2054": 0.11430477350950241, "2059": 0.19782574474811554, "2064": 0.11604541540145874... | 7277084 | The analysis of periodic or repetitive motions is useful in many applications, such as the recognition and classification of human and animal activities. Existing methods for the analysis of periodic motions first extract motion trajectories using spatial information and then determine if they are periodic. These appro... | Extraction and Analysis of Multiple Periodic Motions in Video Sequences |
{"1011": 0.28670501708984375, "1017": 0.0174254160374403, "1018": 0.10993985831737518, "1999": 0.037378571927547455, "2003": 0.04487626627087593, "2004": 0.045809537172317505, "2011": 0.0009760859538801014, "2015": 0.35677260160446167, "2024": 0.010684899985790253, "2029": 0.2247048318386078, "2035": 0.4920966327190399... | 7281161 | Allergic airway inflammation is characterized by marked in situ changes in gene and protein expression, yet the role of microRNAs (miRNAs), a new family of key mRNA regulatory molecules, in this process has not yet been reported. Using a highly sensitive microarray-based approach, we identified 21 miRNAs with different... | MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. |
{"1040": 0.0038986403960734606, "1057": 0.12728634476661682, "1997": 0.04487626627087593, "1998": 0.09050461649894714, "2031": 0.07612881064414978, "2054": 0.006812678650021553, "2062": 0.0913962796330452, "2070": 0.5336109399795532, "2087": 0.3499138653278351, "2088": 0.5104349255561829, "2092": 0.04394211992621422, "... | 7285256 | COPD continues to cause a heavy health and economic burden both in the United States and around the world. Some of the risk factors for COPD are well-known and include smoking, occupational exposures, air pollution, airway hyperresponsiveness, asthma, and certain genetic variations, although many questions, such as why... | COPD: epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. |
{"1014": 0.7537717819213867, "1048": 0.520350456237793, "1054": 0.8861536383628845, "1998": 0.2409527748823166, "2015": 0.2852376699447632, "2037": 0.11430477350950241, "2052": 0.1358480453491211, "2057": 0.0019512200960889459, "2071": 0.47463157773017883, "2079": 0.04394211992621422, "2085": 0.08961215615272522, "2097... | 7299977 | The geographic ranges of ticks and tick-borne pathogens are changing due to global and local environmental (including climatic) changes. In this review we explore current knowledge of the drivers for changes in the ranges of ticks and tick-borne pathogen species and strains via effects on their basic reproduction numbe... | Changing geographic ranges of ticks and tick-borne pathogens: drivers, mechanisms and consequences for pathogen diversity |
{"1011": 0.18492233753204346, "1047": 1.0037577152252197, "1052": 0.05046287178993225, "1999": 0.14433705806732178, "2000": 0.1401015669107437, "2005": 0.23324857652187347, "2006": 0.4286321699619293, "2007": 0.05970508232712746, "2029": 0.0354953333735466, "2033": 0.5893046259880066, "2050": 0.9820492267608643, "2076"... | 7317051 | Pancreatic ductal adenocarcinoma (PDA) represents an unmet therapeutic challenge. PDA is addicted to the activity of the mutated KRAS oncogene which is considered so far an undruggable therapeutic target. We propose an approach to target KRAS effectively in patients using RNA interference. To meet this challenge, we ha... | Mutant KRAS is a druggable target for pancreatic cancer. |
{"1001": 0.1602703034877777, "1011": 0.011650617234408855, "1012": 0.1873544454574585, "1046": 0.18654440343379974, "1054": 0.33675122261047363, "2003": 0.2231435477733612, "2005": 0.021256839856505394, "2015": 0.812664806842804, "2052": 0.006812678650021553, "2062": 0.1718502640724182, "2064": 0.1510767638683319, "207... | 7324039 | MOTIVATION Although many next-generation sequencing (NGS) read preprocessing tools already existed, we could not find any tool or combination of tools that met our requirements in terms of flexibility, correct handling of paired-end data and high performance. We have developed Trimmomatic as a more flexible and efficie... | Trimmomatic: a flexible trimmer for Illumina sequence data |
{"1011": 0.574020504951477, "1015": 0.9944084882736206, "1040": 0.5957841277122498, "1045": 0.11168810725212097, "1048": 0.29400965571403503, "1052": 0.7201237678527832, "1056": 0.9225212931632996, "2005": 0.05139094591140747, "2011": 0.2881702482700348, "2028": 0.5756692886352539, "2034": 0.052318159490823746, "2063":... | 7343711 | Successful cancer treatment requires understanding host immune response against tumor cells. PD-1 belongs to the CD28 superfamily of receptors that work as “checkpoints” of immune activation. PD-1 maintains immune self-tolerance to prevent autoimmunity and controls T-cell reaction during infection to prevent excessive ... | Basics of PD-1 in self-tolerance, infection, and cancer immunity |
{"1011": 0.41001203656196594, "1015": 0.15860503911972046, "1155": 0.037378571927547455, "1156": 1.0179725885391235, "2000": 0.0038986403960734606, "2006": 0.05970508232712746, "2011": 0.27342069149017334, "2028": 0.129004567861557, "2029": 0.18329764902591705, "2052": 0.03360854089260101, "2064": 0.16359257698059082, ... | 7357135 | Drug seeking is maintained by encounters with drug-associated cues, and disrupting retrieval of these drug-cue associations would reduce the risk of relapse. Retrieval of cocaine-associated memories is dependent on β-adrenergic receptor (β-AR) activation, and blockade of these receptors induces a persistent retrieval d... | Dissociation of β1- and β2-adrenergic receptor subtypes in the retrieval of cocaine-associated memory. |
{"1011": 0.26146242022514343, "1016": 0.32764431834220886, "1039": 0.46853771805763245, "1040": 0.07068414986133575, "1042": 0.4914994537830353, "1043": 0.19622190296649933, "1048": 0.5455666780471802, "1052": 0.21687394380569458, "1054": 0.47584590315818787, "1056": 0.4113073945045471, "1996": 0.07159364968538284, "20... | 7370282 | To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN). PDPN is expressed by lymphatic endothelial and fibroblastic reticular cells and promotes blood-lymph separation during development b... | Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 |
{"1037": 0.0009760859538801014, "1052": 0.500420093536377, "2001": 0.05694137513637543, "2003": 0.2247048318386078, "2009": 0.0058422754518687725, "2042": 0.04113444685935974, "2045": 0.07884006202220917, "2049": 0.043007105588912964, "2063": 0.36358460783958435, "2072": 0.2918238639831543, "2097": 0.175953671336174, "... | 7373120 | UNLABELLED Coalitions of multinational food and drink businesses have pledged to reformulate their products and to market them responsibly. Largely business-led and self-regulated, the integrity of these voluntary initiatives has been questioned. The Public Health Responsibility Deal in England is an example of a volun... | The Public Health Responsibility Deal: brokering a deal for public health, but on whose terms? |
{"1041": 0.3784096837043762, "2012": 0.848413348197937, "2015": 0.9857001900672913, "2033": 0.5893046259880066, "2073": 0.06429435312747955, "2075": 0.5838727951049805, "2080": 0.2516399025917053, "2128": 0.822151780128479, "2135": 0.11778303235769272, "2152": 0.28890204429626465, "2169": 0.27342069149017334, "2203": 0... | 7373453 | Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory endothelial shear stress (ESS) occur. Low ESS modulates endothelial gene expression through complex mechanoreception and mechanotransd... | Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. |
{"1009": 0.5833279490470886, "1011": 0.09584271162748337, "1015": 0.03925827145576477, "1018": 0.23324857652187347, "1038": 0.440646231174469, "1042": 0.5461324453353882, "1048": 0.5197699069976807, "1055": 0.21214580535888672, "1056": 1.094698429107666, "1059": 0.5941681861877441, "2006": 0.034552380442619324, "2011":... | 7386360 | Infectious pathogens can selectively stimulate activation or suppression of T cells to facilitate their survival within humans. In this study we demonstrate that the trematode parasite Schistosoma mansoni has evolved with two distinct mechanisms to suppress T cell activation. During the initial 4- to 12-wk acute stages... | Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages. |
{"1011": 0.04207121208310127, "1042": 0.4437839686870575, "1054": 0.659380316734314, "2000": 0.2089812457561493, "2003": 0.14264501631259918, "2014": 0.32270604372024536, "2050": 0.23092569410800934, "2064": 0.23556606471538544, "2077": 0.015504186972975731, "2092": 0.16359257698059082, "2109": 0.2652147710323334, "212... | 7396492 | BACKGROUND A novel method of microarray preprocessing--Frozen Robust Multi-array Analysis (fRMA)--has recently been developed. This algorithm allows the user to preprocess arrays individually while retaining the advantages of multi-array preprocessing methods. The frozen parameter estimates required by this algorithm a... | Thawing Frozen Robust Multi-array Analysis (fRMA) |
{"1009": 0.23324857652187347, "1011": 0.3963087201118469, "1015": 0.7737906575202942, "1038": 0.9155091643333435, "1056": 1.216973900794983, "2003": 0.09761575609445572, "2005": 0.1873544454574585, "2008": 0.15943801403045654, "2028": 0.3325583338737488, "2029": 0.17840765416622162, "2034": 0.04207121208310127, "2064":... | 7399084 | T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of t... | Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance |
{"1015": 0.15275461971759796, "1016": 0.19381128251552582, "1043": 0.2954642176628113, "1045": 0.603290855884552, "1058": 0.306306391954422, "2011": 0.3464667797088623, "2012": 0.23092569410800934, "2029": 0.26446542143821716, "2042": 0.012615402229130268, "2043": 0.0029254043474793434, "2048": 0.4932899475097656, "207... | 7416873 | Interphase nuclear repositioning of chromosomes has been implicated in the epigenetic regulation of RNA polymerase (pol) II transcription. However, little is known about the nuclear position–dependent regulation of RNA pol I–transcribed loci. Trypanosoma brucei is an excellent model system to address this question beca... | Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei |
{"1003": 0.272677481174469, "1014": 0.39367714524269104, "1015": 0.09938567131757736, "1039": 0.6558387279510498, "1044": 0.026976587250828743, "1997": 0.09495500475168228, "2002": 0.015504186972975731, "2007": 0.09850110858678818, "2035": 0.4158279001712799, "2044": 0.7057625651359558, "2051": 0.23015019297599792, "21... | 7419612 | BACKGROUND Readmission soon after hospital discharge is an expensive and often preventable event for patients with heart failure. We present a model approved by the National Quality Forum for the purpose of public reporting of hospital-level readmission rates by the Centers for Medicare & Medicaid Services. METHODS AND... | An administrative claims measure suitable for profiling hospital performance on the basis of 30-day all-cause readmission rates among patients with heart failure. |
{"1041": 0.417115718126297, "1052": 0.1677299439907074, "1060": 0.4041621685028076, "2005": 0.09495500475168228, "2033": 0.5295937061309814, "2048": 0.3588210940361023, "2057": 0.02887592278420925, "2058": 0.5438674688339233, "2064": 0.3177432417869568, "2071": 0.18004031479358673, "2075": 0.7925328612327576, "2079": 0... | 7421677 | High-throughput technologies have led to the generation of complex wiring diagrams as a post-sequencing paradigm for depicting the interactions between vast and diverse cellular species. While these diagrams are useful for analyzing biological systems on a large scale, a detailed understanding of the molecular mechanis... | Queueing up for enzymatic processing: correlated signaling through coupled degradation |
{"1017": 0.3750596046447754, "1039": 1.1141164302825928, "1044": 0.3750596046447754, "1046": 0.7881022095680237, "1999": 0.11951763927936554, "2005": 0.11256109178066254, "2007": 0.25239890813827515, "2010": 0.7969439625740051, "2011": 0.47827014327049255, "2015": 0.08603433519601822, "2029": 0.32553088665008545, "2034... | 7426741 | Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) resets the epigenome to an embryonic-like state. Vitamin C enhances the reprogramming process, but the underlying mechanisms are unclear. Here we show that the histone demethylases Jhdm1a/1b are key effectors of somatic cell reprogramming downst... | The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. |
{"1011": 0.18654440343379974, "1018": 0.777387797832489, "1050": 0.8658194541931152, "1998": 0.45994341373443604, "2007": 0.30989447236061096, "2011": 0.22157983481884003, "2026": 0.7229714393615723, "2029": 0.14179791510105133, "2037": 0.10731173306703568, "2038": 0.15943801403045654, "2042": 0.08603433519601822, "206... | 7433668 | Tuberculosis and helminthic infections coexist in many parts of the world, yet the impact of helminth-elicited Th2 responses on the ability of the host to control Mycobacterium tuberculosis (Mtb) infection has not been fully explored. We show that mice infected with the intestinal helminth Nippostrongylus brasiliensis ... | Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway |
{"1998": 0.010684899985790253, "1999": 0.012615402229130268, "2008": 0.02792670577764511, "2011": 0.5174443125724792, "2013": 0.10818854719400406, "2015": 0.16276304423809052, "2024": 0.16524957120418549, "2027": 0.07341018319129944, "2029": 0.09584271162748337, "2031": 0.1873544454574585, "2037": 0.037378571927547455,... | 7438803 | Archaea constitute a considerable fraction of the microbial biomass on Earth. Like Bacteria they have evolved a variety of energy metabolisms using organic and/or inorganic electron donors and acceptors, and many of them are able to fix carbon from inorganic sources. Archaea thus play crucial roles in the Earth's globa... | Archaea in biogeochemical cycles. |
{"1011": 0.02316705882549286, "2003": 0.16276304423809052, "2011": 0.2667117714881897, "2049": 0.1477125883102417, "2063": 0.15943801403045654, "2072": 0.25694093108177185, "2079": 0.045809537172317505, "2089": 0.03831886500120163, "2100": 0.5849615335464478, "2106": 0.0029254043474793434, "2121": 0.10467668622732162, ... | 7447120 | After infection and a prolonged incubation period, the scrapie agent causes a degenerative disease of the central nervous system in sheep and goats. Six lines of evidence including sensitivity to proteases demonstrate that this agent contains a protein that is required for infectivity. Although the scrapie agent is irr... | Novel proteinaceous infectious particles cause scrapie. |
{"1018": 0.04953393340110779, "1041": 0.5767669677734375, "1048": 0.4318077862262726, "1997": 0.22937409579753876, "2001": 0.4879087805747986, "2006": 0.28597161173820496, "2008": 0.058784693479537964, "2010": 0.30989447236061096, "2011": 0.053244512528181076, "2012": 0.3416208028793335, "2013": 0.495672345161438, "201... | 7451018 | Cancer has been recognized for thousands of years. Egyptians believed that cancer occurred at the will of the gods. Hippocrates believed human disease resulted from an imbalance of the four humors: blood, phlegm, yellow bile, and black bile with cancer being caused by excess black bile. The lymph theory of cancer repla... | Viral Carcinogenesis. |
{"1011": 0.32199856638908386, "1039": 0.05786345899105072, "1049": 0.083342544734478, "2000": 0.018384648486971855, "2003": 0.18329764902591705, "2011": 0.1064341589808464, "2015": 0.15023678541183472, "2037": 0.036437395960092545, "2047": 0.15693697333335876, "2051": 0.603290855884552, "2057": 0.06703783571720123, "20... | 7451607 | Many cellular proteins perform their roles within macromolecular assemblies. Hence, an understanding of how these multiprotein complexes form is a fundamental question in cell biology. We developed a translation-controlled pulse-chase system that allows time-resolved isolation of newly forming multiprotein complexes in... | Monitoring spatiotemporal biogenesis of macromolecular assemblies by pulse-chase epitope labeling. |
{"1039": 0.043007105588912964, "1999": 0.0058422754518687725, "2005": 0.5767669677734375, "2021": 0.00875066313892603, "2024": 0.030771657824516296, "2054": 0.006812678650021553, "2058": 0.0354953333735466, "2064": 0.16607704758644104, "2071": 0.15860503911972046, "2076": 0.015504186972975731, "2079": 0.293281584978103... | 7454794 | Statins are widely used in the evidence-based lowering of cardiovascular disease (CVD) risk. The use of these drugs for secondary prevention of CVD is well founded, but their expanding use in primary prevention—in individuals without documented CVD—has raised some concerns. Firstly, evidence suggests that, in primary p... | Statins in the primary prevention of cardiovascular disease |
{"1009": 0.016465263441205025, "1011": 0.19381128251552582, "1015": 0.27044451236724854, "1039": 0.3916989266872406, "1044": 0.42225050926208496, "1052": 0.9178520441055298, "2002": 0.8100618124008179, "2003": 0.12814582884311676, "2010": 0.817850649356842, "2011": 0.20102575421333313, "2029": 0.13925230503082275, "205... | 7465900 | BACKGROUND & AIMS Helicobacter pylori-induced gastric epithelial cell (GEC) apoptosis is a complex process that includes activation of the tumor suppressor p53. p53-mediated apoptosis involves p53 activation, bax transcription, and cytochrome c release from mitochondria. Apurinic/apyrimidinic endonuclease-1 (APE-1) reg... | Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis. |
{"1011": 0.34577593207359314, "1017": 0.07884006202220917, "1037": 0.19381128251552582, "1039": 0.4158279001712799, "1040": 0.5381823778152466, "1056": 0.9929623603820801, "1996": 0.03266380727291107, "1999": 0.00875066313892603, "2009": 0.23710809648036957, "2011": 0.17267228662967682, "2013": 0.029824240133166313, "2... | 7468449 | Ever since the first demonstration of their repetitive sequence and unique replication pathway, telomeres have beguiled researchers with how they function in protecting chromosome ends. Of course much has been learned over the years, and we now appreciate that telomeres are comprised of the multimeric protein/DNA shelt... | A beginning of the end: new insights into the functional organization of telomeres |
{"1011": 0.18329764902591705, "1017": 0.13414156436920166, "1020": 0.757441520690918, "1056": 0.9279413223266602, "1997": 0.06337817758321762, "2002": 0.4734157919883728, "2005": 0.1485546976327896, "2011": 0.32905077934265137, "2015": 0.3019835948944092, "2029": 0.10555581003427505, "2046": 0.3601844012737274, "2079":... | 7481159 | Gram-negative bacteria use the Type VI secretion system (T6SS) to inject toxic proteins into rival bacteria or eukaryotic cells. However, the mechanism of the T6SS is incompletely understood. In the present study, we investigated a conserved component of the T6SS, TssK, using the antibacterial T6SS of Serratia marcesce... | Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex |
{"1011": 0.3723714053630829, "1015": 0.2105647772550583, "1040": 0.32553088665008545, "1052": 0.15275461971759796, "1060": 0.7047978043556213, "2003": 0.2493593990802765, "2011": 0.13499516248703003, "2026": 0.6568518877029419, "2029": 0.0770333781838417, "2046": 0.0752234235405922, "2094": 1.156782865524292, "2099": 0... | 7482674 | Pelizaeus-Merzbacher disease (PMD) is a form of X-linked leukodystrophy caused by mutations in the proteolipid protein 1 (PLP1) gene. Although PLP1 proteins with missense mutations have been shown to accumulate in the rough endoplasmic reticulum (ER) in disease model animals and cell lines transfected with mutant PLP1 ... | Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes |
{"1011": 0.14602625370025635, "1016": 0.30989447236061096, "1017": 0.30558720231056213, "1041": 0.0029254043474793434, "1042": 0.27342069149017334, "1043": 0.3883931338787079, "1044": 0.32270604372024536, "1049": 0.5483922958374023, "1054": 0.981317400932312, "1997": 0.0770333781838417, "2000": 0.07341018319129944, "20... | 7485455 | BACKGROUND Prior to emergence in human populations, zoonoses such as SARS cause occasional infections in human populations exposed to reservoir species. The risk of widespread epidemics in humans can be assessed by monitoring the reproduction number R (average number of persons infected by a human case). However, until... | Using Routine Surveillance Data to Estimate the Epidemic Potential of Emerging Zoonoses: Application to the Emergence of US Swine Origin Influenza A H3N2v Virus |
{"1037": 0.0029254043474793434, "1038": 0.5330380201339722, "2004": 1.0271050930023193, "2005": 0.030771657824516296, "2015": 0.48610860109329224, "2019": 0.08603433519601822, "2042": 0.0606246218085289, "2046": 0.37035053968429565, "2047": 0.10379679501056671, "2052": 0.3019835948944092, "2054": 0.08871890604496002, "... | 7486516 | Asexuals are an important test case for theories of why species exist. If asexual clades displayed the same pattern of discrete variation as sexual clades, this would challenge the traditional view that sex is necessary for diversification into species. However, critical evidence has been lacking: all putative examples... | Independently Evolving Species in Asexual Bdelloid Rotifers |
{"1001": 0.02316705882549286, "1011": 0.1212492436170578, "1052": 0.4412745535373688, "1060": 0.2089812457561493, "1999": 0.007782140281051397, "2005": 0.1619328260421753, "2029": 0.2089812457561493, "2034": 0.15023678541183472, "2053": 0.9958525896072388, "2076": 0.09406650811433792, "2077": 0.03360854089260101, "2083... | 7487927 | The production of ribosomes is ubiquitous and fundamental to life. As such, it is surprising that defects in ribosome biogenesis underlie a growing number of symptomatically distinct inherited disorders, collectively called ribosomopathies. We previously determined that the nucleolar protein, NOL11, is essential for op... | The Ribosome Biogenesis Factor Nol11 Is Required for Optimal rDNA Transcription and Craniofacial Development in Xenopus |
{"1011": 0.10731173306703568, "1015": 0.1221139207482338, "1018": 0.3850763738155365, "1059": 0.021256839856505394, "1996": 0.043007105588912964, "1997": 0.04953393340110779, "1999": 0.4512746334075928, "2003": 0.13499516248703003, "2007": 0.23247487843036652, "2010": 0.8083226680755615, "2011": 0.3683255612850189, "20... | 7488455 | Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but their individual contributions are obfuscated by the complex in vivo milieu of factor redundancy and indirect effects. Genome-wide reconstitution of promoter nucleosome organization with purified proteins resolves this problem and is th... | Genomic Nucleosome Organization Reconstituted with Pure Proteins |
{"1996": 0.4624064862728119, "1999": 0.27342069149017334, "2008": 0.05139094591140747, "2015": 0.6512666940689087, "2024": 0.02412080205976963, "2026": 0.41195443272590637, "2029": 0.27712854743003845, "2037": 0.043007105588912964, "2041": 0.3423145115375519, "2046": 0.2822965085506439, "2073": 0.36900100111961365, "20... | 7489663 | A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocyt... | Identification of splenic reservoir monocytes and their deployment to inflammatory sites. |
{"1011": 0.14518201351165771, "1015": 0.3750596046447754, "1043": 0.8925741910934448, "1060": 0.2478361576795578, "1996": 0.5209306478500366, "1999": 0.20580662786960602, "2005": 0.2711893916130066, "2008": 0.007782140281051397, "2011": 0.0058422754518687725, "2029": 0.2089812457561493, "2043": 0.1677299439907074, "204... | 7492250 | The dentate gyrus has an important role in learning and memory, and adult neurogenesis in the subgranular zone of the dentate gyrus may play a role in the acquisition of new memories. The homeobox gene Prox1 is expressed in the dentate gyrus during embryonic development and adult neurogenesis. Here we show that Prox1 i... | Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis |
{"1017": 0.13755162060260773, "1041": 0.0038986403960734606, "1043": 0.3810817003250122, "1055": 0.39893341064453125, "1998": 0.1212492436170578, "2002": 1.1012130975723267, "2004": 0.3601844012737274, "2010": 0.016465263441205025, "2011": 0.09495500475168228, "2015": 0.5278670787811279, "2029": 0.09050461649894714, "2... | 7492420 | Human embryonic stem cells (hESCs) and induced pluripotent stem cells proliferate rapidly and divide symmetrically producing equivalent progeny cells. In contrast, lineage committed cells acquire an extended symmetrical cell cycle. Self-renewal of tissue-specific stem cells is sustained by asymmetric cell division wher... | The abbreviated pluripotent cell cycle. |
{"1018": 0.2089812457561493, "1052": 0.5860490798950195, "1999": 0.04860413447022438, "2005": 0.02792670577764511, "2011": 0.25467249751091003, "2020": 0.05417001247406006, "2029": 0.11343330889940262, "2033": 0.7934166193008423, "2036": 0.37304413318634033, "2037": 0.029824240133166313, "2042": 0.029824240133166313, "... | 7506409 | Human mesenchymal stem cells (hMSCs) have been widely studied as a source of primary adult stem cells for cell therapy because of their multidifferentiation potential; however, the growth arrest (also known as "premature senescence") often found in hMSCs cultured in vitro has been a major obstacle to the in-depth chara... | Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. |
{"1997": 0.1212492436170578, "1998": 0.12642613053321838, "2011": 0.22079704701900482, "2012": 0.08782484382390976, "2025": 0.19862671196460724, "2039": 0.17020416259765625, "2054": 0.14433705806732178, "2057": 0.06520967930555344, "2061": 0.9005423784255981, "2062": 0.11604541540145874, "2064": 0.04487626627087593, "2... | 7514614 | Evolutionary considerations suggest aging is caused not by active gene programming but by evolved limitations in somatic maintenance, resulting in a build-up of damage. Ecological factors such as hazard rates and food availability influence the trade-offs between investing in growth, reproduction, and somatic survival,... | Understanding the Odd Science of Aging |
{"1009": 0.822151780128479, "1020": 0.5410289764404297, "1039": 0.5080875158309937, "1048": 0.7028654217720032, "1998": 0.11778303235769272, "2011": 0.034552380442619324, "2015": 0.056018441915512085, "2024": 0.07612881064414978, "2029": 0.3005385100841522, "2057": 0.08603433519601822, "2063": 0.5272908806800842, "2071... | 7521113 | Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulation of these cells could bear therapeutic potential. However, specific ontogenies of individual pop... | Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. |
{"1003": 0.3127557039260864, "1014": 0.8039615154266357, "1016": 0.0354953333735466, "1018": 0.03925827145576477, "1022": 0.22626367211341858, "1045": 0.736154317855835, "1052": 0.6664261221885681, "1997": 0.35060185194015503, "2000": 0.021256839856505394, "2001": 0.05694137513637543, "2007": 0.02792670577764511, "2020... | 7547329 | BACKGROUND Dealing with heterogeneity in meta-analyses is often tricky, and there is only limited advice for authors on what to do. We investigated how authors addressed different degrees of heterogeneity, in particular whether they used a fixed effect model, which assumes that all the included studies are estimating t... | Dealing with substantial heterogeneity in Cochrane reviews. Cross-sectional study |
{"1015": 0.17267228662967682, "1043": 0.8583967685699463, "1055": 0.791648268699646, "1999": 0.030771657824516296, "2004": 0.08692999184131622, "2011": 0.4568560719490051, "2020": 0.14264501631259918, "2029": 0.16110190749168396, "2038": 0.11604541540145874, "2043": 0.08603433519601822, "2046": 0.07884006202220917, "20... | 7548577 | In the yeast Saccharomyces cerevisiae, glycogen is accumulated as a carbohydrate reserve when cells are deprived of nutrients. Yeast mutated in SNF1, a gene encoding a protein kinase required for glucose derepression, has diminished glycogen accumulation and concomitant inactivation of glycogen synthase. Restoration of... | Antagonistic Controls of Autophagy and Glycogen Accumulation by Snf1p, the Yeast Homolog of AMP-Activated Protein Kinase, and the Cyclin-Dependent |
{"1011": 0.24554696679115295, "1019": 0.1619328260421753, "1041": 0.6296497583389282, "1996": 0.09584271162748337, "1999": 0.13243216276168823, "2003": 0.07793712615966797, "2005": 0.12986256182193756, "2006": 0.10731173306703568, "2008": 0.015504186972975731, "2011": 0.21293537318706512, "2012": 0.3027053773403168, "2... | 7549811 | Polarized transport in neurons is fundamental for the formation of neuronal circuitry. A motor domain-containing truncated KIF5 (a kinesin-1) recognizes axonal microtubules, which are enriched in EB1 binding sites, and selectively accumulates at the tips of axons. However, it remains unknown what cue KIF5 recognizes to... | Preferential binding of a kinesin-1 motor to GTP-tubulin–rich microtubules underlies polarized vesicle transport |
{"1996": 0.46363574266433716, "1997": 0.0797421783208847, "1999": 0.030771657824516296, "2003": 0.17020416259765625, "2010": 0.4487839937210083, "2011": 0.4177590310573578, "2013": 0.4450363218784332, "2015": 0.06429435312747955, "2024": 0.08871890604496002, "2029": 0.07250232994556427, "2031": 0.1994270235300064, "203... | 7552147 | The pancreas is an organ containing two distinct populations of cells, the exocrine cells that secrete enzymes into the digestive tract, and the endocrine cells that secrete hormones into the bloodstream. It arises from the endoderm as a dorsal and a ventral bud which fuse together to form the single organ. Mammals, bi... | Developmental biology of the pancreas. |
{"1043": 0.49864232540130615, "1050": 0.03360854089260101, "2005": 0.32764431834220886, "2007": 0.15275461971759796, "2012": 0.10555581003427505, "2030": 0.5057345628738403, "2086": 0.11517547070980072, "2095": 0.1602703034877777, "2109": 0.3519764244556427, "2135": 0.6664261221885681, "2146": 0.15023678541183472, "214... | 7552215 | OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register, the Current Science meta-register of controlled trials, and reference lists of ide... | Long term pharmacotherapy for obesity and overweight: updated meta-analysis. |
{"1011": 0.04113444685935974, "1037": 0.13755162060260773, "1996": 0.38441169261932373, "1997": 0.12038381397724152, "2003": 0.20102575421333313, "2004": 0.2881702482700348, "2012": 0.06977381557226181, "2015": 0.5295937061309814, "2024": 0.42353010177612305, "2028": 0.3269403576850891, "2029": 0.08603433519601822, "20... | 7560876 | Centrosomes are microtubule-organizing centres of animal cells. They influence the morphology of the microtubule cytoskeleton, function as the base for the primary cilium and serve as a nexus for important signalling pathways. At the core of a typical centrosome are two cylindrical microtubule-based structures termed c... | The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries |
{"1049": 0.3916989266872406, "1051": 0.03831886500120163, "2003": 0.07341018319129944, "2005": 0.12556517124176025, "2011": 0.38174858689308167, "2013": 0.18167030811309814, "2026": 1.0073304176330566, "2033": 0.09584271162748337, "2058": 0.27044451236724854, "2075": 0.4330752193927765, "2079": 0.11430477350950241, "21... | 7568596 | Multiple myeloma is largely incurable, despite development of therapies that target myeloma cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells, localized in specialized niches, which resist therapy and repopulate the tumour. However, little is known about the niche, and how it e... | Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche |
{"1011": 0.14349138736724854, "1041": 0.6144463419914246, "1047": 0.5805994272232056, "1060": 0.6744182109832764, "1997": 0.014542185701429844, "1998": 0.4450363218784332, "2003": 0.0029254043474793434, "2004": 0.11778303235769272, "2007": 0.07159364968538284, "2008": 0.03831886500120163, "2011": 0.04674193635582924, "... | 7581911 | Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological properties, and molecular analyses suggest that the pluripotent state of human ESCs isolated so far corresponds to that of mouse-derived epiblast stem cells (EpiSCs). Here we rewire the identity of c... | Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. |
{"1003": 0.015504186972975731, "1038": 0.28082266449928284, "1040": 0.3622259199619293, "1085": 0.6244332790374756, "1999": 0.25694093108177185, "2005": 0.0797421783208847, "2019": 0.0354953333735466, "2035": 0.3723714053630829, "2042": 0.23324857652187347, "2043": 0.15359249711036682, "2044": 0.5849615335464478, "2045... | 7583104 | PURPOSE Mesh surgeries are counted among the most frequently applied surgical procedures. Despite global spread of mesh applying surgeries, there is no current systematic analysis of incidence and possible prevention of adverse events after mesh implantation. MATERIALS AND METHODS Based on the recommendations of IDEAL ... | IDEAL in meshes for prolapse, urinary incontinence, and hernia repair. |
{"1020": 0.11430477350950241, "1051": 0.347847044467926, "1056": 0.5833279490470886, "1996": 0.03925827145576477, "1997": 0.13414156436920166, "1999": 0.07341018319129944, "2002": 0.08603433519601822, "2003": 0.08871890604496002, "2011": 0.11256109178066254, "2013": 0.24018502235412598, "2015": 0.2026219218969345, "202... | 7583161 | In semisyngeneic heterotopic bone marrow transplants the donor or recipient origin of cells of osteogenic and hematopoietic tissues was identified by chromosome markers (T6) and by reverse transplantation into the initial donor line. In syngeneic and semisyngeneic grafts of bone marrow under the renal capsule bone and ... | Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. |
{"1009": 0.66441810131073, "1021": 0.5421652793884277, "1052": 0.15526613593101501, "1056": 0.35677260160446167, "1060": 0.22937409579753876, "2005": 0.175953671336174, "2008": 0.07884006202220917, "2026": 0.6950984001159668, "2029": 0.27044451236724854, "2033": 0.4286321699619293, "2076": 0.030771657824516296, "2078":... | 7583725 | TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity. TRPM7 has been implicated in control of cell adhesion and migration, but whether TRPM7 activity contributes to cancer progression has not been established. Here we report that high levels of TRPM7 expression independently predict poor outc... | TRPM7 is required for breast tumor cell metastasis. |
{"1011": 0.04113444685935974, "1037": 0.037378571927547455, "2003": 0.2018241584300995, "2015": 0.052318159490823746, "2022": 0.004870930220931768, "2042": 0.056018441915512085, "2053": 0.14686977863311768, "2054": 0.05786345899105072, "2075": 0.5914691090583801, "2076": 0.1970241367816925, "2089": 0.3464667797088623, ... | 7595742 | Frailty has long been considered synonymous with disability and comorbidity, to be highly prevalent in old age and to confer a high risk for falls, hospitalization and mortality. However, it is becoming recognized that frailty may be a distinct clinical syndrome with a biological basis. The frailty process appears to b... | Frailty Syndrome: A Transitional State in a Dynamic Process |
{"1017": 0.053244512528181076, "1040": 0.40741631388664246, "1041": 0.2317005842924118, "1044": 0.7370892763137817, "1051": 0.22782009840011597, "1052": 0.38174858689308167, "1997": 0.009718249551951885, "2001": 0.04674193635582924, "2002": 0.0038986403960734606, "2004": 0.037378571927547455, "2007": 0.1586050391197204... | 7602348 | BACKGROUND Preclinical diastolic dysfunction (PDD) has been defined as subjects with normal systolic function, diastolic dysfunction but no symptoms of heart failure (HF). The clinical phenotype and natural history of the syndrome remains poorly defined. This study's objective was to determine the clinical phenotype an... | Progression of preclinical diastolic dysfunction to the development of symptoms. |
{"1998": 0.0058422754518687725, "2001": 0.04113444685935974, "2004": 0.9732321500778198, "2005": 0.5063233375549316, "2038": 0.020300358533859253, "2039": 0.18816383183002472, "2042": 0.2026219218969345, "2044": 0.29473719000816345, "2045": 0.2026219218969345, "2051": 0.0038986403960734606, "2062": 0.10818854719400406,... | 7613033 | Considerable evidence supports the effectiveness of aspirin for chemoprevention of colorectal cancer (CRC) in addition to its well-established benefits in the prevention of vascular disease. Epidemiologic studies have consistently observed an inverse association between aspirin use and risk of CRC. A recent pooled anal... | Aspirin in the chemoprevention of colorectal neoplasia: an overview. |
{"1011": 0.14602625370025635, "1015": 0.1510767638683319, "1017": 0.1994270235300064, "1021": 0.2607102394104004, "1039": 1.0080435276031494, "1060": 0.33115679025650024, "1999": 0.0797421783208847, "2004": 0.29981520771980286, "2005": 0.25845035910606384, "2007": 0.2918238639831543, "2011": 0.29473719000816345, "2029"... | 7621534 | Although chemokines are well established to function in immunity and endothelial cell activation and proliferation, a rapidly growing literature suggests that CXC Chemokine receptors CXCR3, CXCR4 and CXCR7 are critical in the development and progression of solid tumors. The effect of these chemokine receptors in tumori... | Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. |
{"1016": 0.2317005842924118, "1037": 0.6128603219985962, "1043": 0.5590575933456421, "1047": 0.21922965347766876, "1052": 0.6369074583053589, "1055": 0.8264343738555908, "1998": 0.016465263441205025, "1999": 0.16607704758644104, "2000": 0.08961215615272522, "2005": 0.0354953333735466, "2008": 0.026025565341114998, "201... | 7622767 | We have used microinjection and time-lapse video microscopy to study the role of cyclin A in mitosis. We have injected purified, active cyclin A/cyclin-dependent kinase 2 (CDK2) into synchronized cells at specific points in the cell cycle and assayed its effect on cell division. We find that cyclin A/CDK2 will drive G2... | Human Cyclin a Is Required for Mitosis until Mid Prophase |
{"1018": 0.36697331070899963, "2005": 0.04674193635582924, "2011": 0.11168810725212097, "2044": 0.35334911942481995, "2052": 0.16359257698059082, "2063": 0.37102460861206055, "2064": 0.4831010699272156, "2065": 0.006812678650021553, "2071": 0.48430517315864563, "2076": 0.0038986403960734606, "2077": 0.8357921838760376,... | 7627167 | BACKGROUND The objective of this study was to evaluate the effectiveness of a brief, 4-session cognitive behavioral, group psychotherapy for binge eating among bariatric surgery candidates at an academic medical center. Binge eating behaviors have been linked to poorer outcomes among bariatric surgery patients, and bin... | Brief, four-session group CBT reduces binge eating behaviors among bariatric surgery candidates. |
{"1019": 0.22001366317272186, "2001": 0.052318159490823746, "2007": 0.0029254043474793434, "2010": 0.15777134895324707, "2020": 0.05139094591140747, "2025": 0.1011524572968483, "2043": 0.18573370575904846, "2044": 0.848413348197937, "2052": 0.02316705882549286, "2053": 0.18167030811309814, "2084": 0.013579257763922215,... | 7639744 | OBJECTIVE To systematically review the evidence that smoking cessation after diagnosis of a primary lung tumour affects prognosis. DESIGN Systematic review with meta-analysis. DATA SOURCES CINAHL (from 1981), Embase (from 1980), Medline (from 1966), Web of Science (from 1966), CENTRAL (from 1977) to December 2008, and ... | Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta-analysis |
{"1051": 0.8400169610977173, "1055": 0.07341018319129944, "2005": 0.07884006202220917, "2008": 0.12470348179340363, "2011": 0.259204238653183, "2013": 0.401551216840744, "2015": 1.1350497007369995, "2025": 0.0606246218085289, "2029": 0.056018441915512085, "2046": 0.3850763738155365, "2061": 0.8169882297515869, "2064": ... | 7640058 | The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oocyte. More recently, transcription factors have been identified that can induce pluripotency in somatic cells without the use of o... | Epigenetic reprogramming and induced pluripotency. |
{"1003": 0.018384648486971855, "1011": 0.16607704758644104, "1014": 0.08961215615272522, "1020": 0.08064348995685577, "1022": 0.13670019805431366, "1999": 0.0317181795835495, "2007": 0.2470736801624298, "2011": 0.0174254160374403, "2015": 0.8869584798812866, "2043": 0.052318159490823746, "2044": 0.5596157908439636, "20... | 7640792 | CONTEXT Conflicting information exists about whether sex differences modulate short-term mortality following acute coronary syndromes (ACS). OBJECTIVES To investigate the relationship between sex and 30-day mortality in ACS, and to determine whether this relationship was modified by clinical syndrome or coronary anatom... | Sex differences in mortality following acute coronary syndromes. |
{"1011": 0.18816383183002472, "1020": 0.3956514894962311, "1047": 0.6270449161529541, "1050": 0.5438674688339233, "1051": 0.4734157919883728, "1996": 0.06795065850019455, "1997": 0.05970508232712746, "1999": 0.07431721687316895, "2007": 0.02792670577764511, "2008": 0.176772341132164, "2013": 0.4624064862728119, "2025":... | 7643848 | We have characterized the membrane topology of a 60-kDa inner membrane protein from Escherichia coli that is homologous to the recently identified Oxa1p protein in Saccharomyces cerevisiae mitochondria implicated in the assembly of mitochondrial inner membrane proteins. Hydrophobicity and alkaline phosphatase fusion an... | Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli. |
{"1019": 0.2105647772550583, "1020": 0.5914691090583801, "1038": 0.9440274834632874, "1044": 0.9546096324920654, "1057": 0.09850110858678818, "1060": 1.1689931154251099, "2002": 1.2123361825942993, "2005": 0.016465263441205025, "2010": 0.3141832649707794, "2011": 0.347847044467926, "2013": 0.04767346754670143, "2029": ... | 7645565 | Hepatitis B X protein (HBx) plays an essential role in the hepatitis B virus (HBV) replication cycle, but the function of HBx has been elusive until recently. It was recently shown that transcription from the HBV genome (covalently-closed circular DNA, cccDNA) is inhibited by the structural maintenance of chromosome 5/... | Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6 |
{"1016": 0.06520967930555344, "1039": 1.0158531665802002, "1044": 0.6228629946708679, "1045": 0.20421554148197174, "1058": 0.15860503911972046, "2002": 1.2187074422836304, "2005": 0.056018441915512085, "2007": 0.18816383183002472, "2010": 0.33115679025650024, "2011": 0.06703783571720123, "2012": 0.13925230503082275, "2... | 7647224 | Background. Hepatitis C virus (HCV) is an underappreciated cause of pediatric liver disease, most frequently acquired by vertical transmission (VT). Current guidelines that include the option of screening infants for HCV RNA at 1-2 months are based on data prior to current real-time polymerase chain reaction (PCR)-base... | Hepatitis C Virus (HCV) Vertical Transmission in 12-Month-Old Infants Born to HCV-Infected Women and Assessment of Maternal Risk Factors |
{"1009": 0.6441128253936768, "1014": 0.24859806895256042, "1016": 0.045809537172317505, "1017": 0.2026219218969345, "1019": 0.1619328260421753, "1020": 0.058784693479537964, "1052": 0.15442965924739838, "1054": 0.7881022095680237, "2005": 0.21530038118362427, "2007": 0.3810817003250122, "2012": 0.14686977863311768, "20... | 7650066 | BACKGROUND Several studies have shown that testing for high-risk human papillomavirus (HPV) types results in an improved sensitivity for CIN2+, compared with cytology, although with a somewhat lower specificity. METHODS We obtained follow-up results, with at least one smear after participation in the HART study, which ... | Long-term follow-up of cervical disease in women screened by cytology and HPV testing: results from the HART study |
{"1003": 0.02412080205976963, "1014": 0.12642613053321838, "1037": 0.3027053773403168, "1042": 0.33115679025650024, "1056": 0.06977381557226181, "2000": 0.004870930220931768, "2007": 0.004870930220931768, "2035": 0.05786345899105072, "2040": 0.469759464263916, "2043": 0.10906458646059036, "2086": 0.259204238653183, "20... | 7655029 | BACKGROUND Blindness due to trachoma is avoidable through Surgery, Antibiotics, Facial hygiene and Environmental improvements (SAFE). Recent surveys have shown trachoma to be a serious cause of blindness in Southern Sudan. We conducted this survey in Ayod County of Jonglei State to estimate the need for intervention ac... | The Burden of Trachoma in Ayod County of Southern Sudan |
{"1996": 0.09584271162748337, "2000": 0.07884006202220917, "2003": 0.006812678650021553, "2008": 0.014542185701429844, "2011": 0.33605360984802246, "2013": 0.255429208278656, "2015": 0.14518201351165771, "2029": 0.04394211992621422, "2035": 0.018384648486971855, "2041": 0.0038986403960734606, "2054": 0.1602703034877777... | 7662206 | One-fourth of all deaths in industrialized countries result from coronary heart disease. A century of research has revealed the essential causative agent: cholesterol-carrying low-density lipoprotein (LDL). LDL is controlled by specific receptors (LDLRs) in liver that remove it from blood. Mutations that eliminate LDLR... | A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins |
{"1021": 0.3883931338787079, "1023": 0.13755162060260773, "1989": 0.06246116757392883, "2001": 0.05786345899105072, "2018": 0.06703783571720123, "2020": 0.10906458646059036, "2028": 0.23402166366577148, "2043": 0.040196798741817474, "2044": 0.3883931338787079, "2086": 0.18248429894447327, "2095": 0.16524957120418549, "... | 7662395 | OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999-2000. DESIGN Retrospective cohort study. Pregnancies in a cohort of women followed from registration of pregnancy to outcome of infant seven days after b... | Perinatal mortality in rural China: retrospective cohort study. |
{"1011": 0.022212404757738113, "1038": 0.8796916007995605, "1039": 0.8383291959762573, "1047": 0.20580662786960602, "1999": 0.01934296265244484, "2007": 0.5110208988189697, "2008": 0.05786345899105072, "2011": 0.37707099318504333, "2015": 0.15777134895324707, "2025": 0.10291612148284912, "2029": 0.255429208278656, "204... | 7666498 | Mitosis is controlled by multiple kinases that drive cell cycle progression and prevent chromosome mis-segregation. Aurora kinase B interacts with survivin, borealin and incenp to form the chromosomal passenger complex (CPC), which is involved in the regulation of microtubule-kinetochore attachments and cytokinesis. Wh... | Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. |
{"1011": 0.00875066313892603, "1996": 0.011650617234408855, "2005": 0.17759032547473907, "2007": 0.11778303235769272, "2008": 0.015504186972975731, "2011": 0.27934664487838745, "2029": 0.19782574474811554, "2048": 0.5784112811088562, "2053": 0.13071982562541962, "2063": 0.23092569410800934, "2076": 0.45994341373443604,... | 7681810 | Mitotic spindle assembly is mediated by two processes: a centrosomal and a chromosomal pathway. RanGTP regulates the latter process by releasing microtubule-associated proteins from inhibitory complexes. NuSAP, a microtubule- and DNA-binding protein, is a target of RanGTP and promotes the formation of microtubules near... | NuSAP is essential for chromatin-induced spindle formation during early embryogenesis. |
{"1011": 0.4311734735965729, "1015": 0.036437395960092545, "1016": 0.6588751673698425, "1017": 0.06429435312747955, "1018": 0.2881702482700348, "1019": 0.4267219603061676, "1020": 1.0073304176330566, "1040": 0.4450363218784332, "1041": 1.0808777809143066, "1042": 0.47463157773017883, "1055": 0.4158279001712799, "1997":... | 7688110 | The E2F family of transcription factors are essential for the regulation of genes required for appropriate progression through the cell cycle. Five members of the E2F family have been previously reported, namely E2F1-5. All five are key elements in transcriptional regulation of essential genes, and they can be divided ... | E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription |
{"1006": 0.22079704701900482, "1009": 0.6128603219985962, "1011": 0.02792670577764511, "1014": 0.10467668622732162, "1016": 0.1718502640724182, "1019": 0.007782140281051397, "1021": 0.15777134895324707, "1047": 0.7389566898345947, "1052": 0.20739519596099854, "1999": 0.03360854089260101, "2012": 0.2470736801624298, "20... | 7708803 | The slow afterhyperpolarization (sAHP) in hippocampal neurons has been implicated in learning and memory. However, its precise role in cell excitability and central nervous system function has not been explicitly tested for 2 reasons: 1) there are, at present, no selective inhibitors that effectively reduce the underly... | Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). |
{"1018": 0.2696990668773651, "1055": 0.1808556467294693, "1997": 0.13071982562541962, "2001": 0.15860503911972046, "2011": 0.040196798741817474, "2012": 0.7728893756866455, "2015": 0.07068414986133575, "2033": 0.5898461937904358, "2034": 0.23633737862110138, "2041": 0.21293537318706512, "2043": 0.08244366943836212, "20... | 7711685 | This review will reconsider the current paradigm for understanding the critical, final steps in the progression of atherosclerotic lesions. That scheme, largely an outgrowth of observations of autopsy tissues by Davies and colleagues,1 2 asserts that the cause of death in atherosclerotic coronary artery disease is rupt... | Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. |
{"1015": 0.6527929902076721, "1044": 0.012615402229130268, "1997": 0.004870930220931768, "2011": 0.28082266449928284, "2012": 0.34300774335861206, "2028": 0.33953672647476196, "2029": 0.09850110858678818, "2034": 0.35403475165367126, "2035": 1.0992631912231445, "2049": 0.09672962874174118, "2076": 0.2800849378108978, "... | 7717468 | Microbial survival in a host is usually dependent on the ability of a pathogen to undergo changes that promote escape from host defense mechanisms. The human-pathogenic fungus Cryptococcus neoformans undergoes phenotypic switching in vivo that promotes persistence in tissue. By microarray and real-time PCR analyses, th... | Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. |
{"1041": 0.11778303235769272, "1043": 0.9886114001274109, "1045": 1.12938392162323, "1188": 0.08244366943836212, "1996": 0.026025565341114998, "2003": 0.2749055027961731, "2005": 0.2447827309370041, "2008": 0.14686977863311768, "2011": 0.29255300760269165, "2024": 0.37035053968429565, "2029": 0.0752234235405922, "2050"... | 7729656 | Ionotropic glutamate receptors (iGluRs) constitute a family of ligand-gated ion channels that are essential for mediating fast synaptic transmission in the central nervous system. These receptors play an important role for the development and function of the nervous system, and are essential in learning and memory. How... | Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators. |
{"1044": 0.5893046259880066, "1048": 0.37102460861206055, "1052": 0.35745587944984436, "2011": 0.25694093108177185, "2026": 0.3615458607673645, "2042": 0.053244512528181076, "2058": 0.04487626627087593, "2076": 0.0770333781838417, "2102": 0.9302552938461304, "2106": 0.06977381557226181, "2109": 0.46363574266433716, "21... | 7734150 | Pulmonary hypertension (PH) causes loss of body weight and inspiratory (diaphragm) muscle dysfunction. A model of PH induced by drug (monocrotaline, MCT) has been extensively used in mice to examine the etiology of PH. However, it is unclear if PH induced by MCT in mice reproduces the loss of body weight and diaphragm ... | Diaphragm Atrophy and Contractile Dysfunction in a Murine Model of Pulmonary Hypertension |
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