spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1005": 0.004870930220931768, "1011": 0.14095009863376617, "1039": 0.1602703034877777, "1040": 0.6064908504486084, "1042": 0.6512666940689087, "1047": 0.9013357162475586, "1050": 0.6228629946708679, "1055": 0.3784096837043762, "1164": 0.6144463419914246, "1999": 0.03925827145576477, "2005": 0.13670019805431366, "2011"... | 7735859 | BACKGROUND Crohn's disease (CD)-associated dysbiosis is characterised by a loss of Faecalibacterium prausnitzii, whose culture supernatant exerts an anti-inflammatory effect both in vitro and in vivo. However, the chemical nature of the anti-inflammatory compounds has not yet been determined. METHODS Peptidomic analysi... | Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease. |
{"1006": 0.13925230503082275, "1009": 0.8500841856002808, "1011": 0.15359249711036682, "1015": 0.43875885009765625, "1016": 0.6583697199821472, "1039": 0.10555581003427505, "1041": 0.6070231795310974, "1043": 0.35813871026039124, "1052": 0.41195443272590637, "1055": 0.43812891840934753, "2004": 0.052318159490823746, "2... | 7736860 | Store-operated Ca(2+) entry (SOCE) is the principal Ca(2+) entry mechanism in nonexcitable cells. Stromal-interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca(2+) sensor that triggers SOCE activation. However, the role of STIM1 in regulating cancer progression remains controversial and its clinical relevance i... | Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. |
{"1004": 0.18004031479358673, "1017": 0.33325836062431335, "1050": 0.11168810725212097, "1052": 0.175953671336174, "1054": 0.4794800877571106, "2000": 0.25845035910606384, "2001": 0.0009760859538801014, "2003": 0.026976587250828743, "2007": 0.04860413447022438, "2018": 0.26146242022514343, "2022": 0.2493593990802765, "... | 7751726 | INTRODUCTION Recurrent miscarriage (RM) is diagnosed when a woman has had three or more miscarriages. Increased levels of distress and anxiety are common during the waiting period of any subsequent pregnancies, posing a significant threat to psychological well-being. However, only limited support and therapy are availa... | A feasibility study for a randomised controlled trial of the Positive Reappraisal Coping Intervention, a novel supportive technique for recurrent miscarriage |
{"1003": 0.28450319170951843, "1006": 0.3262358605861664, "1011": 0.15526613593101501, "1037": 0.6075552701950073, "1048": 0.4831010699272156, "1057": 0.27786844968795776, "2001": 0.020300358533859253, "2004": 0.129004567861557, "2005": 0.06520967930555344, "2011": 0.11256109178066254, "2012": 0.5478278398513794, "2029... | 7757997 | It has been estimated that approximately 37% of the US population judged to be at high risk for developing coronary artery disease (CAD), based on the National Cholesterol Education Program guidelines, have increased plasma lipoprotein(a) [Lp(a)], whereas Lp(a) is increased in only 14% of those judged to be at low risk... | Report of the National Heart, Lung, and Blood Institute Workshop on Lipoprotein(a) and Cardiovascular Disease: recent advances and future directions. |
{"1058": 0.5914691090583801, "1996": 0.1358480453491211, "1998": 0.07250232994556427, "2005": 0.23247487843036652, "2011": 0.3127557039260864, "2027": 0.11343330889940262, "2029": 0.083342544734478, "2031": 0.13157635927200317, "2037": 0.23092569410800934, "2038": 0.11168810725212097, "2041": 0.026025565341114998, "204... | 7764903 | Both eukaryotic and prokaryotic cells release small, phospholipid-enclosed vesicles into their environment. Why do cells release vesicles? Initial studies showed that eukaryotic vesicles are used to remove obsolete cellular molecules. Although this release of vesicles is beneficial to the cell, the vesicles can also be... | Classification, functions, and clinical relevance of extracellular vesicles. |
{"1011": 0.2837681770324707, "1017": 0.47463157773017883, "1053": 0.3982778787612915, "1998": 0.5506471395492554, "2000": 0.3241194784641266, "2013": 0.07341018319129944, "2015": 0.21293537318706512, "2028": 0.07159364968538284, "2030": 0.009718249551951885, "2031": 0.05786345899105072, "2034": 0.6588751673698425, "204... | 7766808 | In systematic reviews and meta-analysis, researchers often pool the results of the sample mean and standard deviation from a set of similar clinical trials. A number of the trials, however, reported the study using the median, the minimum and maximum values, and/or the first and third quartiles. Hence, in order to comb... | Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range |
{"1042": 0.6075552701950073, "1043": 0.006812678650021553, "1045": 0.15860503911972046, "1056": 0.8796916007995605, "1999": 0.025073638185858727, "2003": 0.014542185701429844, "2007": 0.10203468054533005, "2011": 0.40741631388664246, "2029": 0.22782009840011597, "2033": 0.4950772523880005, "2058": 0.6573580503463745, "... | 7795952 | Fascin, an actin-bundling protein overexpressed in all carcinomas, has been associated with poor prognosis, shorter survival, and more metastatic diseases. It is believed that fascin facilitates tumor metastasis by promoting the formation of invasive membrane protrusions. However, the mechanisms by which fascin is over... | Fascin protein is critical for transforming growth factor β protein-induced invasion and filopodia formation in spindle-shaped tumor cells. |
{"1020": 0.083342544734478, "1056": 0.5301685929298401, "2014": 0.2223619967699051, "2033": 0.2317005842924118, "2061": 0.6038249135017395, "2064": 0.40481385588645935, "2071": 0.15860503911972046, "2075": 0.09050461649894714, "2086": 0.4500300884246826, "2095": 0.058784693479537964, "2109": 0.6548244953155518, "2110":... | 7808055 | BACKGROUND It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure. RESULTS I developed a multi-tissue predictor of age that allows one to estimate the ... | DNA methylation age of human tissues and cell types |
{"1003": 0.04860413447022438, "1011": 0.1477125883102417, "1039": 0.3850763738155365, "1999": 0.35403475165367126, "2007": 0.2447827309370041, "2012": 0.6296497583389282, "2026": 0.5127768516540527, "2060": 0.4950772523880005, "2064": 0.025073638185858727, "2080": 0.02316705882549286, "2084": 0.1913948506116867, "2086"... | 7813993 | Coronary heart disease (CHD) patients often show atherosclerotic vascular disease in other vascular territories. We evaluated how often whole-body MR imaging detects concomitant arterial pathologies in CHD patients, and how often these pathologies were not known to the patients previously. Of 4,814 participants in the ... | Whole-body MR vascular screening detects unsuspected concomitant vascular disease in coronary heart disease patients |
{"1011": 0.3388410806655884, "1015": 0.3949938118457794, "1017": 0.07793712615966797, "1020": 0.0797421783208847, "1045": 0.21214580535888672, "1047": 0.6118015646934509, "1049": 0.4067663550376892, "1057": 0.5936289429664612, "1996": 0.08154398202896118, "2003": 0.010684899985790253, "2005": 0.3248254358768463, "2008"... | 7820043 | The mitochondrial antiviral signaling protein (MAVS; also known as IPS-1, VISA, and CARDIF) is essential for innate immune response against RNA viruses. MAVS transduces signals from the cytosolic RIG-I-like receptors, which bind to viral RNAs. But how MAVS activates downstream transcription factors such as IRF3 to indu... | Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. |
{"1011": 0.1930064558982849, "1018": 0.24171993136405945, "1038": 0.6714286804199219, "1060": 0.4067663550376892, "2007": 0.056018441915512085, "2012": 0.20660123229026794, "2029": 0.12556517124176025, "2033": 0.8255793452262878, "2044": 0.8298473954200745, "2058": 0.47463157773017883, "2066": 0.021256839856505394, "20... | 7821634 | Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However, many patients have residual cancer after chemotherapy, which correlates with a higher risk of metastatic recurrence and poorer outcome than those who achieve a pCR. We hypothesized that molecul... | Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance |
{"1038": 0.13925230503082275, "1997": 0.4709797203540802, "2003": 0.06795065850019455, "2005": 0.09406650811433792, "2022": 0.034552380442619324, "2045": 0.25845035910606384, "2052": 0.23633737862110138, "2064": 0.3374483287334442, "2071": 0.35128939151763916, "2077": 0.7067264318466187, "2079": 0.3134697377681732, "20... | 7834603 | There has been a great deal of interest in identifying potential biomarkers of aging. Biomarkers of aging would be useful to predict potential vulnerabilities in an individual that may arise well before they are chronologically expected, due to idiosyncratic aging rates that occur between individuals. Prior attempts to... | Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans. |
{"1048": 0.4624064862728119, "2003": 0.12814582884311676, "2048": 0.04767346754670143, "2054": 0.22626367211341858, "2079": 0.026025565341114998, "2090": 0.3019835948944092, "2109": 0.2478361576795578, "2110": 0.3656192123889923, "2117": 0.2969166338443756, "2126": 0.15526613593101501, "2129": 0.22859740257263184, "216... | 7837879 | Contraction theory provides an elegant way to analyze the behavior of certain nonlinear dynamical systems. In this paper, we discuss the application of contraction to synchronization of diffusively interconnected components described by nonlinear differential equations. We provide estimates of convergence of the differ... | Synchronization of Diffusively-Connected Nonlinear Systems: Results Based on Contractions with Respect to General Norms |
{"1011": 0.4556184411048889, "1012": 0.053244512528181076, "1044": 0.2741633653640747, "2000": 0.05694137513637543, "2003": 0.3177432417869568, "2005": 0.16524957120418549, "2054": 0.02412080205976963, "2057": 0.05786345899105072, "2063": 0.04860413447022438, "2079": 0.056018441915512085, "2083": 0.6338034868240356, "2... | 7838799 | MOTIVATION High-throughput 'ChIP-chip' and 'ChIP-seq' methodologies generate sufficiently large data sets that analysis poses significant informatics challenges, particularly for research groups with modest computational support. To address this challenge, we devised a software platform for storing, analyzing and visua... | GeneTrack--a genomic data processing and visualization framework. |
{"1022": 0.3297532796859741, "1041": 0.07612881064414978, "1058": 1.1530905961990356, "2001": 0.029824240133166313, "2003": 0.02887592278420925, "2011": 0.05694137513637543, "2019": 0.4145384132862091, "2063": 0.22392450273036957, "2064": 0.004870930220931768, "2083": 0.11081436276435852, "2099": 0.12814582884311676, "... | 7840442 | A multisite optical recording technique consisting of an array of 464 photodiodes was used to measure dynamic changes in transmembrane potentials (Vm) of guinea-pig and mouse enteric neurones stained with the voltage-sensitive dye Di-8-ANEPPS. Optical recordings of Vm changes in enteric neurones which were evoked by de... | Multisite optical recording of excitability in the enteric nervous system. |
{"1011": 0.1905880719423294, "1015": 0.13071982562541962, "1018": 0.27564704418182373, "1042": 0.04674193635582924, "1056": 0.5069117546081543, "1997": 0.2470736801624298, "1998": 0.2223619967699051, "1999": 0.18978065252304077, "2002": 0.6128603219985962, "2007": 0.1011524572968483, "2008": 0.04860413447022438, "2012"... | 7848113 | Vertebrate telomeres consist of tandem repeats of T2AG3 and associated proteins including the telomeric DNA-binding proteins, TRF1 and TRF2. It has been proposed that telomeres assume two interswitchable states, the open state that is accessible to various trans-acting factors and the closed state that excludes those f... | Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats. |
{"1997": 0.11778303235769272, "2003": 0.2231435477733612, "2007": 0.27786844968795776, "2012": 0.09495500475168228, "2048": 0.09495500475168228, "2075": 0.28963330388069153, "2079": 0.0317181795835495, "2090": 0.11604541540145874, "2098": 0.3283478021621704, "2109": 0.04207121208310127, "2110": 0.09317722171545029, "21... | 7850867 | Margination of white blood cells (WBCs) towards vessel walls is an essential precondition for their efficient adhesion to the vascular endothelium. We perform numerical simulations with a two-dimensional blood flow model to investigate the dependence of WBC margination on hydrodynamic interactions of blood cells with t... | Margination of white blood cells in microcapillary flow. |
{"1014": 0.3519764244556427, "2000": 0.25694093108177185, "2001": 0.151916041970253, "2004": 0.05970508232712746, "2006": 0.10731173306703568, "2018": 0.15860503911972046, "2020": 0.14095009863376617, "2031": 0.04767346754670143, "2034": 0.6754127144813538, "2042": 0.26296505331993103, "2043": 0.21530038118362427, "205... | 7852582 | We report a single-centre prospective audit of 29 lung cancer patients who were awaiting radical (potentially curative) radiotherapy. This was the total number assessed as suitable for radical treatment by one consultant during 1999. At the time of assessment they had been newly diagnosed and staged with a computed tom... | Lung cancer treatment waiting times and tumour growth. |
{"1011": 0.3127557039260864, "1016": 0.6773988008499146, "1021": 0.2659635543823242, "1044": 0.7417513132095337, "1056": 0.5197699069976807, "1997": 0.10203468054533005, "1999": 0.016465263441205025, "2000": 0.09228714555501938, "2002": 0.0606246218085289, "2007": 0.5849615335464478, "2008": 0.1677299439907074, "2011":... | 7860396 | The pathway of gene expression in higher eukaryotes involves a highly complex network of physical and functional interactions among the different machines involved in each step of the pathway. Here we established an efficient in vitro system to determine how RNA polymerase II (RNAP II) transcription is functionally cou... | Functional coupling of RNAP II transcription to spliceosome assembly. |
{"1009": 1.1375575065612793, "1011": 0.10203468054533005, "1016": 0.4437839686870575, "1039": 0.3916989266872406, "1999": 0.016465263441205025, "2004": 0.12642613053321838, "2005": 0.16442140936851501, "2011": 0.2822965085506439, "2012": 0.10731173306703568, "2029": 0.05970508232712746, "2043": 0.04113444685935974, "20... | 7869794 | Ca2+ messages are broadly important in cellular signal transduction. In immune cells, Ca2+ signaling is an essential step in many forms of activation. Neutrophil-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is one form of leukocyte activation that plays an important role in tumor cell killing in vitro ... | Calicum microdomains form within neutrophils at the neutrophil–tumor cell synapse: role in antibody-dependent target cell apoptosis |
{"1011": 0.0317181795835495, "1013": 0.10731173306703568, "1014": 0.6228629946708679, "1016": 0.6471850275993347, "1017": 0.5914691090583801, "1020": 0.151916041970253, "1038": 0.16110190749168396, "1043": 0.4412745535373688, "1052": 0.472198486328125, "2005": 0.08782484382390976, "2007": 0.2447827309370041, "2015": 0.... | 7873737 | BACKGROUND Diabetes mellitus is a major risk factor for adverse outcomes after acute coronary syndromes (ACS). Because this disease may be associated with increased platelet aggregation, we investigated whether diabetic patients with ACS derive particular benefit from platelet glycoprotein (GP) IIb/IIIa receptor inhibi... | Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes. |
{"1011": 0.11865071207284927, "1021": 0.4831010699272156, "1043": 0.4425300657749176, "1048": 0.5466978549957275, "1050": 0.42608439922332764, "1052": 0.06795065850019455, "2004": 0.026976587250828743, "2011": 0.3777405619621277, "2029": 0.20818853378295898, "2076": 0.09850110858678818, "2089": 0.03360854089260101, "20... | 7875158 | We previously observed that glucose deprivation induces cell death in multidrug-resistant human breast carcinoma cells (MCF-7/ADR). As a follow up we wished to test the hypothesis that metabolic oxidative stress was the causative process or at least the link between causative processes behind the cytotoxicity. In the s... | Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells. |
{"1011": 0.38041436672210693, "1015": 0.20102575421333313, "1050": 0.9248477816581726, "1056": 0.37371641397476196, "1996": 0.1873544454574585, "1997": 0.06429435312747955, "1999": 0.18248429894447327, "2003": 0.14095009863376617, "2005": 0.09050461649894714, "2007": 0.25467249751091003, "2010": 0.755608320236206, "202... | 7878807 | The Ndc80 complex is the key microtubule-binding element of the kinetochore. In contrast to the well-characterized interaction of Ndc80-Nuf2 heads with microtubules, little is known about how the Spc24-25 heterodimer connects to centromeric chromatin. Here, we present molecular details of Spc24-25 in complex with the h... | A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. |
{"1011": 0.026025565341114998, "1018": 0.6181373596191406, "1043": 0.5393219590187073, "1052": 0.8450632095336914, "2007": 0.13925230503082275, "2015": 0.7510106563568115, "2029": 0.34300774335861206, "2050": 0.3353555500507355, "2072": 0.5080875158309937, "2119": 0.08244366943836212, "2128": 0.1332872211933136, "2155"... | 7898952 | We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconstitution of p18(INK4C) in GBM cells null for both p16(INK4A) and p18(INK4C) resulted in imp... | Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development |
{"1011": 0.13243216276168823, "1013": 0.1485546976327896, "1019": 0.15777134895324707, "1020": 0.8600510358810425, "1997": 0.08603433519601822, "2000": 0.1221139207482338, "2004": 0.02316705882549286, "2005": 0.07793712615966797, "2007": 0.02792670577764511, "2008": 0.053244512528181076, "2011": 0.49030399322509766, "2... | 7915836 | Most cancer cells activate telomerase to elongate telomeres and achieve unlimited replicative potential. Some cancer cells cannot activate telomerase and use telomere homologous recombination (HR) to elongate telomeres, a mechanism termed alternative lengthening of telomeres (ALT). A hallmark of ALT cells is the recrui... | The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins |
{"1011": 0.016465263441205025, "1040": 1.0907690525054932, "1061": 0.10731173306703568, "1996": 0.18492233753204346, "1997": 0.03266380727291107, "2003": 0.3353555500507355, "2008": 0.1970241367816925, "2011": 0.015504186972975731, "2024": 0.11604541540145874, "2029": 0.1485546976327896, "2037": 0.15777134895324707, "2... | 7925817 | Dynein is a microtubule motor that powers motility of cilia and flagella. There is evidence that the relative sliding of the doublet microtubules is due to a conformational change in the motor domain that moves a microtubule bound to the end of an extension known as the stalk. A predominant model for the movement invol... | Dynein pulls microtubules without rotating its stalk. |
{"1011": 0.27342069149017334, "1022": 0.24171993136405945, "1050": 0.06520967930555344, "1051": 0.319873183965683, "1055": 0.7445381283760071, "1996": 0.17267228662967682, "1999": 1.15000319480896, "2003": 0.2763880789279938, "2004": 0.0317181795835495, "2008": 0.14349138736724854, "2013": 0.10379679501056671, "2029": ... | 7929932 | The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution ... | The INO80 chromatin remodeling complex in transcription, replication and repair. |
{"1011": 0.28082266449928284, "1015": 0.500420093536377, "1043": 0.4196864068508148, "1045": 0.6603899002075195, "1058": 0.4914994537830353, "2007": 0.11430477350950241, "2008": 0.1477125883102417, "2011": 0.3423145115375519, "2012": 0.16607704758644104, "2028": 0.176772341132164, "2029": 0.34922540187835693, "2035": 1... | 7944381 | Allelic exclusion underpins antigenic variation and immune evasion in African trypanosomes. These bloodstream parasites use RNA polymerase-I (pol-I) to transcribe just one telomeric variant surface glycoprotein (VSG) gene at a time, producing superabundant and switchable VSG coats. We identified trypanosome VSG exclusi... | VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. |
{"1009": 0.23402166366577148, "1011": 0.16524957120418549, "1016": 0.5438674688339233, "1042": 0.22548456490039825, "1047": 1.2152372598648071, "1048": 0.1751343309879303, "1052": 0.04207121208310127, "1999": 0.07431721687316895, "2012": 0.02887592278420925, "2029": 0.23092569410800934, "2048": 0.01934296265244484, "20... | 7948486 | Kruppel-like factor 2 (KLF2) plays an important role in the regulation of a variety of immune cells, including monocytes. We have previously shown that KLF2 inhibits proinflammatory activation of monocytes. However, the role of KLF2 in arthritis is yet to be investigated. In the current study, we show that recruitment ... | Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1β-induced arthritis. |
{"1014": 0.09495500475168228, "1050": 0.004870930220931768, "1052": 0.4624064862728119, "1056": 0.32058215141296387, "1166": 0.29036402702331543, "1171": 0.6400018334388733, "1998": 0.14518201351165771, "2042": 0.08244366943836212, "2051": 0.3850763738155365, "2053": 0.21530038118362427, "2084": 0.32553088665008545, "2... | 7965928 | IMPORTANCE Concussion and subconcussive impacts have been associated with short-term disrupted cognitive performance in collegiate athletes, but there are limited data on their long-term neuroanatomic and cognitive consequences. OBJECTIVE To assess the relationships of concussion history and years of football experienc... | Relationship of collegiate football experience and concussion with hippocampal volume and cognitive outcomes. |
{"1039": 0.040196798741817474, "1996": 0.0354953333735466, "2003": 0.07341018319129944, "2005": 0.2881702482700348, "2029": 0.0029254043474793434, "2064": 0.1930064558982849, "2076": 0.0354953333735466, "2079": 0.2478361576795578, "2109": 0.24018502235412598, "2114": 0.42353010177612305, "2138": 0.07431721687316895, "2... | 7968532 | Cytosolic detection of pathogen-derived nucleic acids is critical for the initiation of innate immune defense against diverse bacterial, viral and eukaryotic pathogens. Conversely, inappropriate responses to cytosolic nucleic acids can produce severe autoimmune pathology. The host protein STING has been identified as a... | STING and the innate immune response to nucleic acids in the cytosol |
{"1043": 0.27934664487838745, "1049": 0.030771657824516296, "2000": 0.03831886500120163, "2005": 0.3615458607673645, "2015": 0.17922431230545044, "2026": 0.9680526852607727, "2033": 0.12728634476661682, "2039": 0.48430517315864563, "2062": 0.10818854719400406, "2064": 0.27564704418182373, "2069": 0.27712854743003845, "... | 7970974 | Identifying genomic elements required for viability is central to our understanding of the basic physiology of bacterial pathogens. Recently, the combination of high-density mutagenesis and deep sequencing has allowed for the identification of required and conditionally required genes in many bacteria. Genes, however, ... | Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis |
{"1011": 0.045809537172317505, "1041": 0.8161250352859497, "1999": 0.06337817758321762, "2005": 0.33675122261047363, "2007": 0.00875066313892603, "2011": 0.3777405619621277, "2029": 0.20022670924663544, "2060": 0.1510767638683319, "2063": 0.3777405619621277, "2071": 0.22859740257263184, "2109": 0.12470348179340363, "21... | 7975937 | The mechanisms by which melanoma and other cancer cells evade anti-tumor immunity remain incompletely understood. Here, we show that the growth of tumors formed by mutant Braf(V600E) mouse melanoma cells in an immunocompetent host requires their production of prostaglandin E2, which suppresses immunity and fuels tumor-... | Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity |
{"1060": 0.7491656541824341, "1155": 0.5393219590187073, "1998": 0.1677299439907074, "1999": 0.0038986403960734606, "2005": 0.06612417846918106, "2007": 0.5370414853096008, "2010": 0.5290185213088989, "2011": 0.052318159490823746, "2025": 0.05970508232712746, "2029": 0.1710275560617447, "2038": 0.1401015669107437, "204... | 7986878 | We previously reported that intetumumab (CNTO 95), a fully human anti-αv integrin monoclonal antibody, is a radiosensitizer in mice with xenograft tumors. Because intetumumab does not cross-react with mouse integrins, but has cross-reactivity with rat integrins, we next studied the potential combined use of radiation t... | Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation therapy and reduces metastasis of human cancer xenografts in nude rats. |
{"1049": 0.01934296265244484, "1059": 0.5540198087692261, "1999": 0.05417001247406006, "2012": 0.08244366943836212, "2029": 0.05417001247406006, "2033": 0.9147270321846008, "2042": 0.06520967930555344, "2043": 0.04113444685935974, "2051": 0.07431721687316895, "2058": 0.3297532796859741, "2075": 0.175953671336174, "2076... | 7988832 | Epigenetic processes play a key role in orchestrating transcriptional regulation during development. The importance of DNA methylation in fetal brain development is highlighted by the dynamic expression of de novo DNA methyltransferases during the perinatal period and neurodevelopmental deficits associated with mutatio... | Methylomic trajectories across human fetal brain development. |
{"1011": 0.0038986403960734606, "1054": 0.2231435477733612, "1060": 0.26146242022514343, "2004": 0.23324857652187347, "2011": 0.2018241584300995, "2033": 0.9515975713729858, "2042": 0.026976587250828743, "2045": 0.1734936386346817, "2071": 0.4709797203540802, "2107": 0.23864774405956268, "2128": 0.9394577741622925, "21... | 7997337 | There is mounting evidence showing that the structural and molecular organization of synaptic connections is affected both in human patients and in animal models of neurological and psychiatric diseases. As a consequence of these experimental observations, it has been introduced the concept of synapsopathies, a notion ... | Synaptic Determinants of Rett Syndrome |
{"1018": 0.4728073179721832, "1019": 0.02412080205976963, "1022": 0.12986256182193756, "1040": 0.07431721687316895, "1049": 0.3005385100841522, "1998": 0.4487839937210083, "2001": 0.007782140281051397, "2012": 0.3163207769393921, "2040": 0.029824240133166313, "2043": 0.05694137513637543, "2053": 0.14518201351165771, "2... | 8002529 | CONTEXT Significant symptoms of depression are common in the older community-dwelling population. Although depressive symptoms and disability may commonly occur in the same person, whether depressive symptoms contribute to subsequent functional decline has not been elucidated. OBJECTIVE To determine whether depressive ... | Depressive symptoms and physical decline in community-dwelling older persons. |
{"1011": 0.15023678541183472, "1015": 0.11081436276435852, "1044": 0.02316705882549286, "2003": 0.19782574474811554, "2004": 0.04207121208310127, "2005": 0.05694137513637543, "2010": 0.5973974466323853, "2011": 0.3374483287334442, "2012": 0.23402166366577148, "2029": 0.31845372915267944, "2075": 0.21135559678077698, "2... | 8002887 | Autophagy is the primary catabolic process triggered in response to starvation. Although autophagic regulation within the cytosolic compartment is well established, it is becoming clear that nuclear events also regulate the induction or repression of autophagy. Nevertheless, a thorough understanding of the mechanisms b... | Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs |
{"1011": 0.1332872211933136, "1038": 0.2026219218969345, "1047": 0.3353555500507355, "1052": 0.3622259199619293, "1054": 0.1212492436170578, "1058": 0.0354953333735466, "2002": 0.6043586730957031, "2003": 0.043007105588912964, "2005": 0.07068414986133575, "2007": 0.15943801403045654, "2011": 0.09228714555501938, "2031"... | 8005007 | Porcine reproductive and respiratory syndrome virus (PRRSV) has a restricted cell tropism and prefers to invade well-differentiated cells of the monocyte/macrophage lineage, such as pulmonary alveolar macrophages and African green monkey kidney cell line MA-104 and its derivatives, such as Marc-145, Vero and CL-2621. P... | PRRSV receptors and their roles in virus infection |
{"2011": 0.3019835948944092, "2029": 0.10555581003427505, "2042": 0.09495500475168228, "2043": 0.10555581003427505, "2044": 0.23092569410800934, "2057": 0.03360854089260101, "2064": 0.3601844012737274, "2076": 0.4537591338157654, "2079": 0.06977381557226181, "2109": 0.04674193635582924, "2110": 0.23015019297599792, "21... | 8006440 | Considerable details about microRNA (miRNA) biogenesis and regulation have been uncovered, but little is known about the fate of the miRNA subsequent to target regulation. To gain insight into this process, we carried out kinetic analysis of a miRNA's turnover following termination of its biogenesis and during regulati... | Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells |
{"1011": 0.07793712615966797, "1018": 0.007782140281051397, "1042": 0.23556606471538544, "1049": 0.06246116757392883, "2000": 0.06703783571720123, "2003": 0.12038381397724152, "2005": 0.07793712615966797, "2064": 0.013579257763922215, "2083": 0.30917787551879883, "2100": 0.19381128251552582, "2109": 0.4267219603061676,... | 8025177 | Flow cytometry (FCM) using DNA-selective fluorochromes is now the prevailing method for the measurement of nuclear DNA content in plants. Ease of sample preparation and high sample throughput make it generally better suited than other methods such as Feulgen densitometry to estimate genome size, level of generative pol... | Estimation of nuclear DNA content in plants using flow cytometry |
{"1020": 0.006812678650021553, "1026": 0.31204116344451904, "1028": 0.07431721687316895, "1048": 0.043007105588912964, "1050": 0.3318578004837036, "1052": 0.27934664487838745, "1057": 0.36967599391937256, "1060": 0.18816383183002472, "1062": 0.969535231590271, "2004": 0.1913948506116867, "2005": 0.0019512200960889459, ... | 8037453 | PURPOSE Three large, randomized trials of patients with bone metastases recently demonstrated that zoledronic acid reduces the risk of skeletal-related events. These trials provide an opportunity for investigating the correlation between bone metabolism and clinical outcome during bisphosphonate therapy. PATIENTS AND M... | Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. |
{"1009": 0.4855078160762787, "1011": 0.3070250153541565, "1018": 0.1734936386346817, "1021": 0.3777405619621277, "1022": 0.6563454270362854, "1038": 0.7445381283760071, "1039": 0.2689530849456787, "1045": 0.35745587944984436, "1048": 0.1873544454574585, "1056": 0.7934166193008423, "1999": 0.014542185701429844, "2005": ... | 8038329 | Although the role of CD28-B7 interaction in the activation of naive T cells is well established, its importance in the generation and maintenance of T cell memory is not well understood. In this study, we examined the requirement for CD28-B7 interactions in primary T cell activation and immune memory. Ag-specific CD8 T... | Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. |
{"1017": 0.09317722171545029, "1037": 0.021256839856505394, "1054": 0.08692999184131622, "2003": 0.0029254043474793434, "2004": 0.04207121208310127, "2009": 0.05417001247406006, "2042": 0.09495500475168228, "2043": 0.03266380727291107, "2054": 0.23864774405956268, "2055": 0.2223619967699051, "2079": 0.2969166338443756,... | 8042158 | Systematic literature reviews are widely used as an aid to evidence based decision making. For example, reviews of randomised controlled trials are regularly used to answer questions about the effectiveness of healthcare interventions. The high profile of systematic reviews as a cornerstone of evidence based medicine, ... | Systematic reviews from astronomy to zoology: myths and misconceptions. |
{"1011": 0.11691460013389587, "1018": 0.02316705882549286, "1038": 0.5116065740585327, "1056": 0.4891071021556854, "1057": 0.10291612148284912, "1059": 0.861702561378479, "1998": 0.0038986403960734606, "2001": 0.16607704758644104, "2003": 0.40351006388664246, "2007": 0.0770333781838417, "2011": 0.28963330388069153, "20... | 8063697 | Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen Bordetella pertussis. Pertussis rates in the United States have been rising and reached a 50-y high of 42,000 cases in 2012. Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (... | Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model. |
{"1011": 0.18248429894447327, "1038": 0.8212929964065552, "1041": 1.0430610179901123, "1042": 0.08154398202896118, "1999": 0.08961215615272522, "2000": 0.11430477350950241, "2006": 0.012615402229130268, "2007": 0.6086184978485107, "2008": 0.19220098853111267, "2011": 0.12986256182193756, "2012": 0.3519764244556427, "20... | 8065561 | Fluorometric titration of E. coli single-stranded DNA binding protein with various RNAs showed that the protein specifically and cooperatively binds to its own mRNA. The binding inhibited in vitro expression of ssb and bla but not nusA. This inhibition takes place at a physiological concentration of SSB. The function o... | Specific and cooperative binding of E. coli single-stranded DNA binding protein to mRNA. |
{"1039": 0.23092569410800934, "1057": 0.38041436672210693, "1059": 0.23324857652187347, "2001": 0.3353555500507355, "2003": 0.016465263441205025, "2004": 0.16110190749168396, "2005": 0.176772341132164, "2007": 0.1913948506116867, "2008": 0.07793712615966797, "2020": 0.007782140281051397, "2021": 0.020300358533859253, "... | 8069939 | Smallpox was eradicated more than 30 years ago, but heightened concerns over bioterrorism have brought smallpox and smallpox vaccination back to the forefront. The previously licensed smallpox vaccine in the United States, Dryvax (Wyeth Laboratories, Inc.), was highly effective, but the supply was insufficient to vacci... | ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile |
{"1014": 0.43875885009765625, "1023": 0.07431721687316895, "1048": 0.6223390698432922, "1998": 0.2231435477733612, "2001": 0.018384648486971855, "2004": 0.02887592278420925, "2007": 0.4494072198867798, "2019": 0.2247048318386078, "2020": 0.09672962874174118, "2042": 0.30989447236061096, "2045": 0.3163207769393921, "205... | 8082528 | BACKGROUND For over 20 years the association between sarcoidosis and malignancy, particularly lymphoma and lung cancer, has been disputed with misclassification being the major concern. The aim of the present study was to analyse the incidence of malignancies in a cohort of patients with sarcoidosis by linkage to a nat... | Risk of malignant neoplasms in patients with pulmonary sarcoidosis. |
{"1019": 0.75193190574646, "1022": 0.17267228662967682, "1023": 0.013579257763922215, "1040": 0.04207121208310127, "1052": 0.5197699069976807, "1054": 0.8550800085067749, "1055": 0.66441810131073, "2011": 0.11604541540145874, "2015": 0.8298473954200745, "2019": 0.47827014327049255, "2026": 0.8459017872810364, "2029": 0... | 8083310 | Impaired erythropoiesis in the deletion 5q (del(5q)) subtype of myelodysplastic syndrome (MDS) has been linked to heterozygous deletion of RPS14, which encodes the ribosomal protein small subunit 14. We generated mice with conditional inactivation of Rps14 and demonstrated an erythroid differentiation defect that is de... | Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9 |
{"1011": 0.058784693479537964, "1996": 0.4673144817352295, "2005": 0.304147332906723, "2007": 0.2696990668773651, "2011": 0.18248429894447327, "2013": 0.03266380727291107, "2015": 0.29255300760269165, "2029": 0.05970508232712746, "2047": 0.02316705882549286, "2048": 0.07068414986133575, "2054": 0.15359249711036682, "20... | 8087082 | The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associated proteins (MAPs), which work in concert with each other, binding MTs and a... | A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis |
{"1011": 0.1332872211933136, "1015": 0.10731173306703568, "1021": 0.7995813488960266, "1041": 0.06429435312747955, "1042": 0.20501139760017395, "1043": 0.12728634476661682, "1055": 0.27342069149017334, "1996": 0.11604541540145874, "2002": 0.4450363218784332, "2003": 0.04394211992621422, "2008": 0.0913962796330452, "201... | 8093935 | Sec7-related guanine nucleotide exchange factors (GEFs) initiate vesicle budding from the Golgi membrane surface by converting the GTPase ARF to a GTP-bound, membrane-associated form. Here we report the crystal structure of the catalytic Sec7 homology domain of Arno, a human GEF for ARF1, determined at 2.2 angstroms re... | Structure of the Guanine Nucleotide Exchange Factor Sec7 Domain of Human Arno and Analysis of the Interaction with ARF GTPase |
{"1009": 0.6853039860725403, "1011": 0.006812678650021553, "1017": 0.3409265875816345, "1040": 0.4145384132862091, "1045": 0.38441169261932373, "1047": 0.4950772523880005, "1048": 0.45623743534088135, "1058": 0.5438674688339233, "1996": 0.29255300760269165, "1999": 0.03925827145576477, "2011": 0.19220098853111267, "201... | 8122346 | The medial prefrontal cortex (mPFC) plays a critical role in cocaine addiction. However, evidence to elucidate how the mPFC is functionally involved in cocaine addiction remains incomplete. Recent studies have revealed that repeated cocaine administration induces various neuroadaptations in pyramidal mPFC neurons, incl... | Brief Communication Repeated Cocaine Administration Increases Voltage-Sensitive Calcium Currents in Response to Membrane Depolarization in Medial Prefrontal Cortex Pyramidal Neurons |
{"1019": 0.04674193635582924, "1020": 0.012615402229130268, "1021": 0.38308101892471313, "1038": 0.19220098853111267, "1997": 0.1332872211933136, "2000": 0.021256839856505394, "2003": 0.2786078155040741, "2005": 0.18978065252304077, "2007": 0.20818853378295898, "2015": 0.1011524572968483, "2029": 0.06703783571720123, "... | 8126244 | Biogenesis of ribosomes is an essential cellular process conserved across all eukaryotes and is known to require >170 genes for the assembly, modification, and trafficking of ribosome components through multiple cellular compartments. Despite intensive study, this pathway likely involves many additional genes. Here, we... | Rational Extension of the Ribosome Biogenesis Pathway Using Network-Guided Genetics |
{"1014": 0.2652147710323334, "1999": 0.11081436276435852, "2046": 0.10818854719400406, "2047": 0.40806588530540466, "2051": 0.36697331070899963, "2058": 0.40351006388664246, "2064": 0.1970241367816925, "2070": 0.1229778528213501, "2079": 0.10555581003427505, "2089": 0.25694093108177185, "2097": 0.17840765416622162, "21... | 8133050 | Many microparasites infect new hosts with specialized life stages, requiring a subset of the parasite population to forgo proliferation and develop into transmission forms. Transmission stage production influences infectivity, host exploitation, and the impact of medical interventions like drug treatment. Predicting ho... | Quantifying Transmission Investment in Malaria Parasites |
{"1011": 0.22157983481884003, "1016": 0.3850763738155365, "1038": 0.055094651877880096, "1042": 0.5415972471237183, "1043": 0.19622190296649933, "1054": 0.08782484382390976, "1056": 0.043007105588912964, "2006": 0.20102575421333313, "2008": 0.010684899985790253, "2011": 0.3464667797088623, "2012": 0.22392450273036957, ... | 8133180 | Germline mutations in the RET tyrosine kinase gene are responsible for the development of multiple endocrine neoplasia 2A and 2B (MEN2A and MEN2B). However, knowledge of the fundamental principles that determine the mutant RET-mediated signaling remains elusive. Here, we report increased expression of mitogen-activated... | Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice |
{"1009": 0.16442140936851501, "1038": 0.53589928150177, "1043": 0.5701626539230347, "1048": 0.18329764902591705, "1056": 0.6144463419914246, "1996": 0.11256109178066254, "1999": 0.07431721687316895, "2007": 0.05786345899105072, "2011": 0.14939609169960022, "2013": 0.06429435312747955, "2015": 0.0058422754518687725, "20... | 8137081 | Leukocyte trafficking between the various body compartments has an important surveillance function that ensures the detection of antigen and enables the immune system to initiate a rapid and effective response. Repeated social defeat of group-housed male mice induced by daily, acute encounters with an aggressive conspe... | Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen |
{"1006": 0.14939609169960022, "1009": 0.46608972549438477, "1011": 0.3019835948944092, "1017": 0.11256109178066254, "1020": 0.18329764902591705, "1037": 0.22548456490039825, "1039": 0.17840765416622162, "1040": 0.5156965255737305, "1048": 0.06795065850019455, "1049": 0.40546512603759766, "1051": 0.42799583077430725, "1... | 8144920 | BACKGROUND Dendritic cells (DC) are the professional antigen-presenting cells of the immune system, fully equipped to prime naive T cells and thus essential components for cancer immunotherapy. METHODS We tested the influence of several elements (cPPT, trip, WPRE, SIN) on the transduction efficiency of human DC. Human ... | Lentivirally transduced dendritic cells as a tool for cancer immunotherapy. |
{"1011": 0.03266380727291107, "1043": 0.5116065740585327, "1055": 0.5133614540100098, "2011": 0.26296505331993103, "2012": 0.10818854719400406, "2033": 0.6754127144813538, "2043": 0.0797421783208847, "2046": 0.055094651877880096, "2051": 0.46117570996284485, "2064": 0.004870930220931768, "2076": 0.659380316734314, "207... | 8148122 | DNA replication in mammals is regulated via the coordinate firing of clusters of replicons that duplicate megabase-sized chromosome segments at specific times during S-phase. Cytogenetic studies show that these "replicon clusters" coalesce as subchromosomal units that persist through multiple cell generations, but the ... | Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation |
{"1011": 0.09050461649894714, "1015": 0.6054253578186035, "1017": 0.0029254043474793434, "1018": 0.08603433519601822, "1996": 0.03831886500120163, "2004": 0.029824240133166313, "2005": 0.04953393340110779, "2008": 0.05046287178993225, "2012": 0.012615402229130268, "2028": 0.35403475165367126, "2029": 0.2756470441818237... | 8148304 | In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expression of IME1, which is required for expression of many meiotic genes, and thus lead to a partial defect in meiosis and spore formation. We report the sequence of ... | Molecular characterization of the yeast meiotic regulatory gene RIM1. |
{"1017": 0.016465263441205025, "1018": 0.1889725625514984, "1040": 0.1913948506116867, "1044": 0.31132611632347107, "1047": 0.00875066313892603, "2003": 0.2089812457561493, "2004": 0.1685553640127182, "2005": 0.2822965085506439, "2010": 0.8534175157546997, "2011": 0.3163207769393921, "2013": 0.2089812457561493, "2015":... | 8150638 | We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the efficiency of induced pluripotent stem (iPS) cell derivation from human adult or fetal fibroblasts. After transient butyrate treatment, the iPS cell derivation efficie... | Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. |
{"1009": 0.7683706283569336, "1011": 0.3163207769393921, "1018": 0.3339579105377197, "1022": 0.44753631949424744, "1038": 0.757441520690918, "1039": 0.6563454270362854, "1048": 0.6872705817222595, "1056": 0.8600510358810425, "1166": 0.255429208278656, "1999": 0.013579257763922215, "2000": 0.04953393340110779, "2005": 0... | 8182950 | In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after intradermal injection, greatly enhances adjuvant efficacy at low do... | Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose. |
{"1011": 0.0354953333735466, "1043": 0.5370414853096008, "1054": 0.12556517124176025, "2000": 0.2800849378108978, "2002": 0.05139094591140747, "2005": 0.32270604372024536, "2006": 0.22548456490039825, "2008": 0.07793712615966797, "2010": 0.9515975713729858, "2011": 0.14349138736724854, "2026": 0.05139094591140747, "202... | 8185080 | Reprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA methyltransferase and histone deacetylase (HDAC) inhibitors improve reprogramming efficiency. In particular, valproic acid (VPA), an HDAC inhibitor, improves repro... | Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds |
{"1003": 0.08244366943836212, "1019": 0.21530038118362427, "1044": 0.3269403576850891, "1050": 0.28450319170951843, "1052": 0.7978238463401794, "1058": 0.07068414986133575, "1998": 0.026025565341114998, "2000": 0.10906458646059036, "2001": 0.08154398202896118, "2007": 0.2659635543823242, "2012": 0.04394211992621422, "2... | 8190282 | CONTEXT Noninvasive ventilation (NIV) has been associated with lower rates of endotracheal intubation in populations of patients with acute respiratory failure. OBJECTIVE To compare NIV with standard treatment using supplemental oxygen administration to avoid endotracheal intubation in recipients of solid organ transpl... | Noninvasive ventilation for treatment of acute respiratory failure in patients undergoing solid organ transplantation: a randomized trial. |
{"1011": 0.17759032547473907, "1018": 0.8550800085067749, "1054": 0.7491656541824341, "2003": 0.5168620347976685, "2008": 0.14433705806732178, "2029": 0.03360854089260101, "2054": 0.09938567131757736, "2063": 1.0567318201065063, "2081": 1.5014698505401611, "2099": 0.053244512528181076, "2106": 0.20580662786960602, "210... | 8202880 | SUMMARY MADE4, microarray ade4, is a software package that facilitates multivariate analysis of microarray gene-expression data. MADE4 accepts a wide variety of gene-expression data formats. MADE4 takes advantage of the extensive multivariate statistical and graphical functions in the R package ade4, extending these fo... | BIOINFORMATICS APPLICATIONS NOTE |
{"1039": 0.3005385100841522, "1043": 0.7086513638496399, "1044": 0.7889899015426636, "1059": 0.38374659419059753, "1996": 0.13499516248703003, "2002": 0.04953393340110779, "2005": 0.3084607720375061, "2006": 0.28082266449928284, "2011": 0.3416208028793335, "2024": 0.004870930220931768, "2029": 0.09850110858678818, "205... | 8208212 | Recent work has shown that primary cilia are essential for Hedgehog (Hh) signaling during mammalian development. It is also known that aberrant Hh signaling can lead to cancer, but the role of primary cilia in oncogenesis is not known. Cerebellar granule neuron precursors (GNPs) can give rise to medulloblastomas, the m... | Dual and opposing roles of primary cilia in medulloblastoma development |
{"1011": 0.06337817758321762, "1054": 0.2954642176628113, "1996": 0.1384023278951645, "1999": 0.20818853378295898, "2005": 0.14095009863376617, "2008": 0.11343330889940262, "2011": 0.2317005842924118, "2029": 0.2652147710323334, "2034": 0.3416208028793335, "2043": 0.006812678650021553, "2076": 0.3560888469219208, "2079... | 8210189 | Ras proteins in budding yeasts initially appeared to regulate initiation of the cell cycle in response to nutrient availability. More recent work, while clarifying the mechanism of Ras-mediated signal transduction, has undermined our notion of the signal Ras transmits. We now suspect that Ras helps to coordinate cellul... | RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway. |
{"1006": 0.22782009840011597, "1009": 0.6823468804359436, "1011": 0.33675122261047363, "1016": 0.20818853378295898, "1017": 0.5080875158309937, "1020": 0.01934296265244484, "1041": 0.38308101892471313, "1042": 0.524982750415802, "1043": 0.7105726003646851, "1044": 0.10818854719400406, "1045": 0.5267143249511719, "1056"... | 8219248 | A set of 57 synthetic peptides encompassing the entire triplehelical domain of human collagen III was used to locate binding sites for the collagen-binding integrin alpha(2)beta(1). The capacity of the peptides to support Mg(2+)-dependent binding of several integrin preparations was examined. Wild-type integrins (recom... | Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III. |
{"1003": 0.2026219218969345, "1019": 0.040196798741817474, "1056": 0.8161250352859497, "1996": 0.24171993136405945, "1999": 0.5914691090583801, "2003": 0.2223619967699051, "2007": 0.5220900774002075, "2011": 0.06977381557226181, "2029": 0.3723714053630829, "2073": 0.2822965085506439, "2075": 0.688742995262146, "2087": ... | 8227227 | The locations of cerebral infarctions were studied in 14 patients with tuberculous meningitis (TBM) and 173 patients with noninflammatory ischemic stroke (IS). In patients with TBM, 75% of infarctions occurred in the “TB zone” supplied by medial striate and thalamoperforating arteries; only 11% occurred in the “IS zone... | Locations of cerebral infarctions in tuberculous meningitis |
{"1009": 0.6907027959823608, "1016": 0.28082266449928284, "1017": 0.06795065850019455, "1018": 0.15526613593101501, "1048": 0.2501201331615448, "1054": 0.06337817758321762, "1996": 0.040196798741817474, "1999": 0.1946154683828354, "2003": 0.020300358533859253, "2024": 0.18329764902591705, "2037": 0.15275461971759796, "... | 8246090 | Ion channels are classically understood to regulate the flux of ions across the plasma membrane in response to a variety of environmental and intracellular cues. Ion channels serve a number of functions in intracellular membranes as well. These channels may be temporarily localized to intracellular membranes as a funct... | TRP channels of intracellular membranes. |
{"1009": 0.11256109178066254, "1011": 0.35334911942481995, "1016": 0.21372433006763458, "1045": 0.08603433519601822, "1048": 0.29109421372413635, "1056": 0.619189441204071, "1157": 0.07159364968538284, "2005": 0.06429435312747955, "2007": 0.24171993136405945, "2011": 0.3170322775840759, "2026": 0.9546096324920654, "202... | 8246922 | BACKGROUND Interleukin (IL)-12 exerts a potent proinflammatory effect by stimulating T-helper (Th) 1 responses. This effect is believed to be mediated primarily through the activation of STAT4 and subsequent production of interferon (IFN)-gamma. Methods and Results- We examined the role of IL-12 receptor (IL-12R) signa... | the Development of Autoimmune Myocarditis in Mice by an |
{"1011": 0.1477125883102417, "1017": 0.06612417846918106, "1038": 0.7528522610664368, "1041": 1.1708117723464966, "1048": 0.2954642176628113, "1058": 0.06246116757392883, "2002": 0.011650617234408855, "2003": 0.2539152204990387, "2006": 0.10731173306703568, "2008": 0.02412080205976963, "2011": 0.08782484382390976, "201... | 8247469 | Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral... | The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines |
{"1055": 0.259204238653183, "2003": 0.5540198087692261, "2011": 0.2145126610994339, "2015": 0.07159364968538284, "2022": 0.35334911942481995, "2024": 0.0019512200960889459, "2076": 0.22704219818115234, "2079": 0.0019512200960889459, "2083": 0.12470348179340363, "2091": 0.6482070088386536, "2179": 0.10993985831737518, "... | 8247597 | Mutations and deletions in the mitochondrial genome (mtDNA), as well as instability of the nuclear genome, are involved in multiple human diseases. Here, we report that in Saccharomyces cerevisiae, loss of mtDNA leads to nuclear genome instability, through a process of cell-cycle arrest and selection we define as a cel... | Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect |
{"1018": 0.10026945173740387, "1022": 0.4132472574710846, "1041": 0.04394211992621422, "1043": 0.040196798741817474, "1047": 0.5685047507286072, "1055": 0.9092346429824829, "1095": 0.08961215615272522, "1997": 0.22782009840011597, "2012": 0.14686977863311768, "2015": 0.04394211992621422, "2025": 0.11691460013389587, "2... | 8250852 | During S phase, the entire genome must be precisely duplicated, with no sections of DNA left unreplicated. Here, we develop a simple mathematical model to describe the probability of replication failing due to the irreversible stalling of replication forks. We show that the probability of complete genome replication is... | Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts |
{"1037": 0.0770333781838417, "1996": 0.083342544734478, "1997": 0.1994270235300064, "1999": 0.0797421783208847, "2002": 0.23402166366577148, "2003": 0.0770333781838417, "2010": 1.27701997756958, "2025": 0.029824240133166313, "2032": 0.034552380442619324, "2037": 0.018384648486971855, "2045": 0.11778303235769272, "2049"... | 8267678 | Chromatin is not an inert structure, but rather an instructive DNA scaffold that can respond to external cues to regulate the many uses of DNA. A principle component of chromatin that plays a key role in this regulation is the modification of histones. There is an ever-growing list of these modifications and the comple... | Regulation of chromatin by histone modifications |
{"1011": 0.07068414986133575, "1039": 0.1401015669107437, "1040": 0.4349733293056488, "1042": 0.49864232540130615, "1047": 0.5778634548187256, "1054": 0.1685553640127182, "2011": 0.18167030811309814, "2012": 0.25694093108177185, "2015": 0.36697331070899963, "2025": 0.22782009840011597, "2026": 0.732405424118042, "2028"... | 8290760 | During cellular reprogramming, only a small fraction of cells become induced pluripotent stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based on populations of cells, impeding single-cell level identification of reprogramming events. We utilized two gene expression technologies to pr... | Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase |
{"1040": 0.1994270235300064, "1058": 0.40546512603759766, "1061": 0.04207121208310127, "1999": 0.38574060797691345, "2000": 0.2105647772550583, "2004": 0.11081436276435852, "2005": 0.2659635543823242, "2006": 0.23402166366577148, "2010": 0.6112717390060425, "2011": 0.3485364317893982, "2012": 0.0913962796330452, "2019"... | 8290953 | BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium over regions of infarcted cardiac tissue to stimulate revascularization of the damaged tissue. These experiments used a scaffold-based 3D human dermal fibroblast culture (3DFC) as an epicardial patch. The 3DFC contains viable cell... | Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue. |
{"1037": 0.17922431230545044, "2001": 0.4067663550376892, "2003": 0.175953671336174, "2013": 0.052318159490823746, "2020": 0.13157635927200317, "2025": 0.10555581003427505, "2040": 0.4512746334075928, "2042": 0.129004567861557, "2043": 0.4267219603061676, "2044": 0.12038381397724152, "2045": 0.10555581003427505, "2054"... | 8294009 | Tuberculosis (TB) is an ancient disease, but not a disease of the past. After disappearing from the world public health agenda in the 1960s and 1970s, TB returned in the early 1990s for several reasons, including the emergence of the HIV/AIDS pandemic and increases in drug resistance. More than 100 years after the disc... | Global tuberculosis control: lessons learnt and future prospects |
{"1003": 0.12642613053321838, "1014": 0.014542185701429844, "1043": 0.8525851964950562, "1052": 0.2576959431171417, "1997": 0.04394211992621422, "2050": 0.3777405619621277, "2062": 0.3248254358768463, "2072": 0.47827014327049255, "2073": 0.00875066313892603, "2084": 0.36967599391937256, "2086": 0.3297532796859741, "208... | 8298120 | PURPOSE Glaucoma is the leading cause of global irreversible blindness. Present estimates of global glaucoma prevalence are not up-to-date and focused mainly on European ancestry populations. We systematically examined the global prevalence of primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG)... | Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. |
{"1009": 0.9147270321846008, "1018": 0.2749055027961731, "1039": 0.3027053773403168, "1048": 0.2018241584300995, "1054": 0.6911921501159668, "1055": 0.02887592278420925, "1056": 1.001607894897461, "1058": 0.15693697333335876, "1998": 0.08603433519601822, "1999": 0.10731173306703568, "2008": 0.07341018319129944, "2029":... | 8300657 | Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4(+) T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4+ T cells in the intestine within days of infection, before any such changes in ... | Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. |
{"1011": 0.4462870955467224, "1016": 0.28082266449928284, "1040": 0.1693800985813141, "1047": 0.8525851964950562, "1049": 0.6833335757255554, "1056": 0.8625272512435913, "1166": 0.04860413447022438, "1997": 0.03360854089260101, "1998": 0.04113444685935974, "2000": 0.025073638185858727, "2006": 0.151916041970253, "2007"... | 8305686 | The binding of oligomeric peptide-MHC (pMHC) complexes to cell surface TCR can be considered to approximate TCR-pMHC interactions at cell-cell interfaces. In this study, we analyzed the equilibrium binding of streptavidin-based pMHC oligomers (tetramers) and their dissociation kinetics from CD8(pos) T cells from 2C-TCR... | Interaction of streptavidin-based peptide-MHC oligomers (tetramers) with cell-surface TCRs. |
{"1014": 0.3423145115375519, "1044": 0.3325583338737488, "1050": 0.13670019805431366, "1052": 0.28155985474586487, "2011": 0.19622190296649933, "2012": 0.6096806526184082, "2029": 0.3339579105377197, "2039": 0.29036402702331543, "2043": 0.18167030811309814, "2046": 0.052318159490823746, "2076": 0.5995445251464844, "208... | 8317408 | Peripheral blood monocytes are involved during atherogenesis in adhering to endothelium, migrating into the subendothelial space and taking-up lipoproteins to become macrophage/foam cells. We have assessed whether peripheral blood monocyte characteristics are altered in human hyperlipidaemia in age/sex/smoking status m... | Human monocyte characteristics are altered in hypercholesterolaemia. |
{"1998": 0.05417001247406006, "2001": 0.05970508232712746, "2029": 0.08782484382390976, "2035": 0.020300358533859253, "2038": 0.15777134895324707, "2042": 0.26146242022514343, "2043": 0.28450319170951843, "2060": 0.1619328260421753, "2061": 0.9944084882736206, "2064": 0.04487626627087593, "2079": 0.46117570996284485, "... | 8318286 | Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscienc... | Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later. |
{"1038": 0.2470736801624298, "1041": 0.8306987881660461, "1043": 0.3464667797088623, "1044": 0.48670899868011475, "1998": 0.2018241584300995, "2005": 0.08782484382390976, "2007": 0.2516399025917053, "2025": 0.13925230503082275, "2029": 0.014542185701429844, "2051": 0.011650617234408855, "2076": 0.12556517124176025, "20... | 8318922 | Strict blood pressure (BP) control is reportedly important for the management of hypertensive patients with chronic kidney disease (CKD). The purpose of this cross-sectional study was to examine whether the variables of ambulatory BP and the heart rate (HR) profile, central hemodynamics, and arterial stiffness were clo... | Relationship of ambulatory blood pressure and the heart rate profile with renal function parameters in hypertensive patients with chronic kidney disease. |
{"1006": 0.0354953333735466, "1009": 0.9944084882736206, "1011": 0.4574742913246155, "1014": 0.3005385100841522, "1015": 0.7182208299636841, "1016": 0.29109421372413635, "1020": 0.45499902963638306, "1022": 0.7791815400123596, "1039": 0.08692999184131622, "1044": 0.4337083101272583, "1045": 0.45623743534088135, "1056":... | 8325952 | OBJECTIVE Islet-reactive CD8(+) T-cells play a key role in the pathogenesis of type 1 diabetes in the NOD mouse. The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown. RESEARCH DESIGN AND METHODS... | The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment. |
{"1011": 0.07793712615966797, "1019": 0.14264501631259918, "1051": 0.40481385588645935, "1055": 0.13499516248703003, "1997": 0.036437395960092545, "1999": 0.06154331564903259, "2004": 0.0913962796330452, "2005": 0.07884006202220917, "2015": 0.27342069149017334, "2029": 0.11604541540145874, "2062": 0.04767346754670143, ... | 8327914 | The assembly of ribosomal subunits in eukaryotes is a complex, multistep process so far mostly studied in yeast. In S. cerevisiae, more than 200 factors including ribosomal proteins and trans-acting factors are required for the ordered assembly of 40S and 60S ribosomal subunits. To date, only few human homologs of thes... | A Protein Inventory of Human Ribosome Biogenesis Reveals an Essential Function of Exportin 5 in 60S Subunit Export |
{"1011": 0.15442965924739838, "1015": 0.015504186972975731, "1017": 0.5127768516540527, "1019": 0.15777134895324707, "1042": 0.1384023278951645, "1044": 0.8674615025520325, "1050": 0.19220098853111267, "1998": 0.11604541540145874, "1999": 0.11951763927936554, "2002": 0.1485546976327896, "2004": 0.1064341589808464, "200... | 8331432 | The transcription factor HNF3 and linker histones H1 and H5 possess winged-helix DNA-binding domains, yet HNF3 and other fork head-related proteins activate genes during development whereas linker histones compact DNA in chromatin and repress gene expression. We compared how the two classes of factors interact with chr... | Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome. |
{"1011": 0.05417001247406006, "1043": 0.44753631949424744, "2004": 0.04113444685935974, "2008": 0.07341018319129944, "2012": 0.30917787551879883, "2013": 0.3662964701652527, "2015": 0.12384103983640671, "2020": 0.14179791510105133, "2029": 0.32270604372024536, "2030": 0.9363996982574463, "2031": 0.05046287178993225, "2... | 8352137 | By employing the nuclear DNA of the African rice Oryza glaberrima as a reference genome, the timing, natures, mechanisms, and specificities of recent sequence evolution in the indica and japonica subspecies of Oryza sativa were identified. The data indicate that the genome sizes of both indica and japonica have increas... | Rapid recent growth and divergence of rice nuclear genomes. |
{"1006": 0.00875066313892603, "1009": 0.16442140936851501, "1011": 0.175953671336174, "1016": 0.056018441915512085, "1056": 0.8933739066123962, "1999": 0.07884006202220917, "2005": 0.02887592278420925, "2011": 0.3656192123889923, "2025": 0.14349138736724854, "2029": 0.2852376699447632, "2048": 0.12814582884311676, "205... | 8354687 | The autoimmune regulator (Aire) plays a critical role in central tolerance by promoting the display of tissue-specific antigens in the thymus. To study the influence of Aire on thymic selection in a physiological setting, we used tetramer reagents to detect autoreactive T cells specific for the Aire-dependent tissue-sp... | Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. |
{"1003": 0.09495500475168228, "1041": 0.4938860833644867, "1048": 0.05694137513637543, "1052": 0.16359257698059082, "1055": 0.16690383851528168, "1999": 0.31489628553390503, "2012": 0.23247487843036652, "2013": 0.0038986403960734606, "2019": 0.8212929964065552, "2020": 0.07431721687316895, "2029": 0.015504186972975731,... | 8373753 | The seasonal dynamics and spatial distributions of Anopheles mosquitoes and Plasmodium falciparum parasites were studied for one year at 30 villages in Malindi, Kilifi, and Kwale Districts along the coast of Kenya. Anopheline mosquitoes were sampled inside houses at each site once every two months and malaria parasite ... | Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast. |
{"1009": 0.18248429894447327, "1021": 0.0797421783208847, "1038": 0.8074519634246826, "1042": 0.8357921838760376, "1056": 0.20580662786960602, "1062": 0.5562619566917419, "1997": 0.0009760859538801014, "2003": 0.22001366317272186, "2006": 0.4500300884246826, "2007": 0.006812678650021553, "2009": 0.41001203656196594, "2... | 8385277 | Fanconi anemia (FA) is a genetic condition associated with bone marrow (BM) failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). We studied 57 FA patients with hypoplastic or aplastic anemia (n = 20), MDS (n = 18), AML (n = 11), or no BM abnormality (n = 8). BM samples were analyzed by karyotype, high-densi... | Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions. |
{"1041": 0.18978065252304077, "1051": 0.2852376699447632, "2003": 0.036437395960092545, "2005": 0.05139094591140747, "2012": 0.08603433519601822, "2019": 0.043007105588912964, "2064": 0.26820653676986694, "2075": 0.029824240133166313, "2079": 0.3019835948944092, "2080": 0.004870930220931768, "2085": 0.15693697333335876... | 8386609 | Optogenetic technologies employ light to control biological processes within targeted cells in vivo with high temporal precision. Here, we show that application of molecular trafficking principles can expand the optogenetic repertoire along several long-sought dimensions. Subcellular and transcellular trafficking strat... | Molecular and Cellular Approaches for Diversifying and Extending Optogenetics |
{"1011": 0.2674594223499298, "1039": 0.757441520690918, "1041": 0.17020416259765625, "1043": 0.33115679025650024, "1997": 0.03266380727291107, "2003": 0.2689530849456787, "2015": 0.5640701055526733, "2020": 0.03360854089260101, "2024": 0.42161011695861816, "2029": 0.08871890604496002, "2034": 0.11865071207284927, "2042... | 8396189 | Lipid rafts are microdomains of the phospholipid bilayer, proposed to form semi-stable "islands" that act as a platform for several important cellular processes; major classes of raft-resident proteins include signalling proteins and glycosylphosphatidylinositol (GPI)-anchored proteins. Proteomic studies into lipid raf... | An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. |
{"1017": 0.1064341589808464, "1052": 0.13414156436920166, "1055": 0.4980490207672119, "2001": 0.14095009863376617, "2012": 0.3923587501049042, "2013": 0.2954642176628113, "2014": 0.1710275560617447, "2020": 0.1602703034877777, "2042": 0.009718249551951885, "2043": 0.2223619967699051, "2050": 0.7528522610664368, "2051":... | 8398627 | PURPOSE The goal of this study is to look at the geographic growth patterns of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections in our local region and to determine if specific geographic areas are at increased risk. METHODS After Institution Review Board approval (132603-3), a retrospec... | Geographic distribution of community-acquired methicillin-resistant Staphylococcus aureus soft tissue infections. |
{"1044": 0.4752389192581177, "2002": 0.41840189695358276, "2010": 1.3769737482070923, "2011": 0.32553088665008545, "2029": 0.015504186972975731, "2037": 0.272677481174469, "2049": 0.5290185213088989, "2079": 0.5584990978240967, "2109": 0.1485546976327896, "2129": 0.026976587250828743, "2135": 0.38041436672210693, "2188... | 8411251 | Histone proteins dynamically regulate chromatin structure and epigenetic signaling to maintain cell homeostasis. These processes require controlled spatial and temporal deposition and eviction of histones by their dedicated chaperones. With the evolution of histone variants, a network of functionally specific histone c... | The right place at the right time: chaperoning core histone variants. |
{"1011": 0.2145126610994339, "1015": 0.9263957738876343, "1043": 0.14602625370025635, "1044": 0.30917787551879883, "2003": 0.2184450328350067, "2011": 0.25239890813827515, "2028": 0.6218147873878479, "2029": 0.2105647772550583, "2034": 0.09850110858678818, "2038": 0.13157635927200317, "2048": 0.04674193635582924, "2051... | 8417211 | HP1 is an essential heterochromatin-associated protein in Drosophila. HP1 has dosage-dependent effects on the silencing of euchromatic genes that are mislocalized to heterochromatin and is required for the normal expression of at least two heterochromatic genes. HP1 is multiply phosphorylated in vivo, and HP1 hyperphos... | Phosphorylation site mutations in heterochromatin protein 1 (HP1) reduce or eliminate silencing activity. |
{"1020": 0.01934296265244484, "1041": 0.12986256182193756, "1048": 0.006812678650021553, "1052": 0.19782574474811554, "1057": 0.43812891840934753, "1996": 0.13925230503082275, "2005": 0.09584271162748337, "2011": 0.34715715050697327, "2013": 0.42926809191703796, "2029": 0.176772341132164, "2037": 0.3269403576850891, "2... | 8425533 | A defining feature of mitochondria is their maternal mode of inheritance. However, little is understood about the cellular mechanism through which paternal mitochondria, delivered from sperm, are eliminated from early mammalian embryos. Autophagy has been implicated in nematodes, but whether this mechanism is conserved... | Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1 |
{"1011": 0.17840765416622162, "1019": 0.31845372915267944, "1050": 0.09228714555501938, "1051": 0.4067663550376892, "2003": 0.0317181795835495, "2004": 0.3191637098789215, "2008": 0.04207121208310127, "2011": 0.3956514894962311, "2015": 0.5751199722290039, "2024": 0.18004031479358673, "2025": 0.48068851232528687, "2029... | 8426046 | Large noncoding RNAs are emerging as an important component in cellular regulation. Considerable evidence indicates that these transcripts act directly as functional RNAs rather than through an encoded protein product. However, a recent study of ribosome occupancy reported that many large intergenic ncRNAs (lincRNAs) a... | Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins |
{"1005": 0.029824240133166313, "1006": 0.14179791510105133, "1015": 0.20580662786960602, "1017": 0.2018241584300995, "1019": 0.2711893916130066, "1022": 0.8649974465370178, "1048": 0.14095009863376617, "1053": 0.4855078160762787, "1056": 0.7764897346496582, "2006": 0.08603433519601822, "2007": 0.14179791510105133, "200... | 8427306 | We have developed a restriction map of the chromosome 21 breakpoint region involved in t(8;21)(q22;q22.3) acute myelogenous leukemia (AML) and have isolated a genomic junction clone containing chromosome 8 and 21 material. Using probes from these regions, rearrangements have been identified in each of nine cases of t(8... | Isolation of a Fusion Transcript, AMLl IETO, With Similarity to |
{"1011": 0.36494144797325134, "1019": 0.8264343738555908, "1055": 0.23092569410800934, "1062": 0.06429435312747955, "1998": 0.29981520771980286, "2004": 1.2047537565231323, "2005": 0.30558720231056213, "2007": 0.27786844968795776, "2019": 0.6603899002075195, "2020": 0.06154331564903259, "2029": 0.10906458646059036, "20... | 8428837 | OBJECTIVE Ankylosing spondylitis (AS) and spondyloarthropathy (SpA) are inflammatory diseases of unknown etiology. Various exogenous and endogenous (inherited) factors play a role in their development. Sulfasalazine (SSZ) is generally accepted as a disease modifying drug in the treatment of AS and SpA. Which part of SS... | Treatment of spondyloarthropathy with 5-aminosalicylic acid (mesalazine): an open trial. |
{"1003": 0.10203468054533005, "1016": 0.30989447236061096, "1018": 0.34508460760116577, "1022": 0.37907835841178894, "1998": 0.0354953333735466, "1999": 0.16276304423809052, "2012": 0.1332872211933136, "2020": 0.0317181795835495, "2037": 0.1710275560617447, "2048": 0.15693697333335876, "2051": 0.3588210940361023, "2058... | 8428935 | CONTEXT Physical inactivity contributes to weight gain in adults, but whether this relationship is true for children of different ethnic groups is not well established. OBJECTIVE To assess participation in vigorous activity and television watching habits and their relationship to body weight and fatness in US children.... | Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey. |
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