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{"1011": 0.2470736801624298, "1016": 0.255429208278656, "1038": 0.7454653382301331, "1051": 0.06795065850019455, "1053": 0.4437839686870575, "1058": 0.4673144817352295, "1059": 0.8264343738555908, "1156": 0.7009293437004089, "1999": 0.05046287178993225, "2011": 0.27712854743003845, "2012": 0.22859740257263184, "2015": ... | 8446259 | Background: Vascular calcification (VC), in which vascular smooth muscle cells (VSMCs) undergo a phenotypic transformation into osteoblast-like cells, is one of the emergent risk factors for the accelerated atherosclerosis process characteristic of chronic kidney disease (CKD). Phosphate is an important regulator of VC... | Vascular Calcification in Chronic Kidney Disease is Induced by Bone Morphogenetic Protein-2 via a Mechanism Involving the Wnt/β-Catenin Pathway |
{"1041": 0.1946154683828354, "1053": 0.16110190749168396, "1060": 0.11081436276435852, "1998": 0.040196798741817474, "1999": 0.3519764244556427, "2000": 0.1751343309879303, "2005": 0.2105647772550583, "2006": 0.47463157773017883, "2022": 0.053244512528181076, "2038": 0.12384103983640671, "2045": 0.16359257698059082, "2... | 8446324 | Advances in the fields of molecular and translational research, oncology, and surgery have emboldened the medical community to believe that intrinsic brain tumors may be treatable. Intraoperative imaging and brain mapping allow operations adjacent to eloquent cortex and more radical resection of tumors with increased c... | Advances in brain tumor surgery. |
{"1043": 0.25995752215385437, "1051": 0.40806588530540466, "2000": 0.052318159490823746, "2005": 0.1384023278951645, "2020": 0.06612417846918106, "2045": 0.39367714524269104, "2053": 0.4764525294303894, "2064": 0.058784693479537964, "2073": 0.30558720231056213, "2080": 0.14264501631259918, "2084": 0.0019512200960889459... | 8447873 | BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best therapy. Despite the recognition of adverse effects, gastric lavage is commonly done in Asia. We aimed to identify studie... | Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning. |
{"1009": 0.07068414986133575, "1011": 0.2881702482700348, "1042": 0.29473719000816345, "1045": 0.06429435312747955, "1054": 0.9115922451019287, "1996": 0.0019512200960889459, "1999": 0.06612417846918106, "2005": 0.10379679501056671, "2011": 0.3897167444229126, "2029": 0.1693800985813141, "2034": 0.16276304423809052, "2... | 8453819 | The integrin family of heterodimeric cell-surface receptors are fundamental in cell-cell and cell-matrix adhesion. Changes to either integrin-ligand affinity or integrin gene expression are central to a variety of disease processes, including inflammation, cardiovascular disease and cancer. In screening for novel activ... | Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum. |
{"1020": 0.14179791510105133, "1022": 0.22626367211341858, "1023": 0.4709797203540802, "1044": 0.04860413447022438, "1060": 0.04674193635582924, "1155": 0.36494144797325134, "1996": 0.06429435312747955, "1999": 0.04487626627087593, "2003": 0.19622190296649933, "2005": 0.053244512528181076, "2008": 0.026025565341114998,... | 8458567 | PEROXISOMES are cytoplasmic organelles which are important in mammals in modulation of lipid homeostasis, including the metabolism of long-chain fatty acids and conversion of cholesterol to bile salts (reviewed in refs 1 and 2). Amphipathic carboxylates such as clofibric acid have been used in man as hypolipidaemic age... | Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors |
{"1015": 0.17840765416622162, "1043": 0.37102460861206055, "1048": 0.1913948506116867, "2004": 0.16359257698059082, "2005": 0.21687394380569458, "2011": 0.14264501631259918, "2064": 0.37640097737312317, "2076": 0.4093637466430664, "2079": 0.2667117714881897, "2080": 0.1358480453491211, "2089": 0.05694137513637543, "209... | 8460275 | Despite being surrounded by diverse nutrients, mammalian cells preferentially metabolize glucose and free amino acids. Recently, Ras-induced macropinocytosis of extracellular proteins was shown to reduce a transformed cell's dependence on extracellular glutamine. Here, we demonstrate that protein macropinocytosis can a... | The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1 |
{"2004": 0.5903874635696411, "2011": 0.06703783571720123, "2035": 0.757441520690918, "2048": 0.2516399025917053, "2057": 0.0354953333735466, "2061": 0.37974658608436584, "2062": 0.17840765416622162, "2064": 0.3170322775840759, "2069": 0.06337817758321762, "2071": 0.04113444685935974, "2087": 0.3027053773403168, "2090":... | 8476213 | We developed a general model of sporophytic self-incompatibility under negative frequency-dependent selection allowing complex patterns of dominance among alleles. We used this model deterministically to investigate the effects on equilibrium allelic frequencies of the number of dominance classes, the number of alleles... | A general model to explore complex dominance patterns in plant sporophytic self-incompatibility systems. |
{"1015": 0.05694137513637543, "1043": 0.4812922179698944, "1047": 0.46117570996284485, "1996": 0.034552380442619324, "1999": 0.0174254160374403, "2011": 0.08064348995685577, "2024": 0.045809537172317505, "2029": 0.18248429894447327, "2030": 0.020300358533859253, "2034": 0.31132611632347107, "2049": 0.2447827309370041, ... | 8477699 | Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can g... | Metabolic Reprograming in Macrophage Polarization |
{"1011": 0.255429208278656, "1039": 0.4267219603061676, "1042": 0.2983669638633728, "2011": 0.10026945173740387, "2029": 0.09850110858678818, "2038": 0.04487626627087593, "2048": 0.2749055027961731, "2073": 0.08064348995685577, "2079": 0.07793712615966797, "2087": 0.2394166737794876, "2090": 0.18978065252304077, "2116"... | 8494570 | BACKGROUND Recent studies suggested that human/mammalian genomes are divided into large, discrete domains that are units of chromosome organization. CTCF, a CCCTC binding factor, has a diverse role in genome regulation including transcriptional regulation, chromosome-boundary insulation, DNA replication, and chromatin ... | Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes |
{"1011": 0.36900100111961365, "1016": 0.8349450826644897, "1017": 0.010684899985790253, "1038": 0.19381128251552582, "1041": 0.28597161173820496, "1044": 0.28890204429626465, "1997": 0.1221139207482338, "1999": 0.05139094591140747, "2004": 0.0842406153678894, "2006": 0.5767669677734375, "2007": 0.0842406153678894, "201... | 8496132 | Overexpression of the proto-oncogene bcl-2 promotes abnormal cell survival by inhibiting apoptosis. Expression of bcl-2 is determined, in part, by regulatory mechanisms that control the stability of bcl-2 mRNA. Elements in the 3'-untranslated region of bcl-2 mRNA have been shown to play a role in regulating the stabili... | Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells. |
{"2042": 0.034552380442619324, "2045": 0.0019512200960889459, "2087": 0.007782140281051397, "2088": 0.5186077356338501, "2107": 0.04113444685935974, "2116": 0.6543170213699341, "2121": 0.4425300657749176, "2129": 0.010684899985790253, "2161": 0.020300358533859253, "2164": 0.03360854089260101, "2166": 0.4100120365619659... | 8502193 | Traits such as clutch size vary markedly across species and environmental gradients but have usually been investigated from either a comparative or a geographic perspective, respectively. We analyzed the global variation in clutch size across 5,290 bird species, excluding brood parasites and pelagic species. We integra... | The Worldwide Variation in Avian Clutch Size across Species and Space |
{"1009": 0.4891071021556854, "1011": 0.0317181795835495, "1014": 0.6867793202400208, "1026": 0.04113444685935974, "1040": 0.47463157773017883, "1041": 0.5186077356338501, "1044": 0.22079704701900482, "1048": 0.2830325961112976, "1052": 0.4041621685028076, "1058": 0.040196798741817474, "2004": 0.15943801403045654, "2007... | 8509018 | BACKGROUND Patients with signs and symptoms of heart failure and a normal left ventricular ejection fraction are said to have diastolic heart failure. It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricl... | Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle. |
{"1011": 0.2501201331615448, "1015": 0.04860413447022438, "1048": 0.672426164150238, "1998": 0.22626367211341858, "2004": 0.06337817758321762, "2007": 0.14939609169960022, "2008": 0.0770333781838417, "2015": 0.4938860833644867, "2024": 0.030771657824516296, "2025": 0.14179791510105133, "2028": 0.036437395960092545, "20... | 8512633 | Long noncoding RNAs (IncRNAs) are increasingly implicated in cancer biology, contributing to essential cancer cell functions such as proliferation, invasion, and metastasis. In prostate cancer, several lncRNAs have been nominated as critical actors in disease pathogenesis. Among these, expression of PCGEM1 and PRNCR1 h... | The lncRNAs PCGEM1 and PRNCR1 are not implicated in castration resistant prostate cancer |
{"1009": 0.20580662786960602, "1052": 0.7881022095680237, "2005": 0.04767346754670143, "2008": 0.06154331564903259, "2011": 0.037378571927547455, "2012": 0.17267228662967682, "2029": 0.23787821829319, "2035": 0.3656192123889923, "2054": 0.0606246218085289, "2058": 0.5092619061470032, "2076": 0.05694137513637543, "2099"... | 8519911 | Aging is a complex organismal process that is controlled by genetic, environmental, and behavioral factors. Accumulating evidence supports a role for different cell cycle inhibitors in mammalian aging. Little is known, however, about the upstream signals that induce their expression. Here, we explore the role of p38MAP... | p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. |
{"1017": 0.06337817758321762, "1051": 0.06154331564903259, "1054": 0.13414156436920166, "2007": 0.2317005842924118, "2011": 0.08782484382390976, "2035": 0.3683255612850189, "2060": 0.27786844968795776, "2063": 0.07341018319129944, "2064": 0.21687394380569458, "2066": 0.5450005531311035, "2070": 0.06977381557226181, "20... | 8520041 | OBJECTIVE We explored the subjective effects associated with olanzapine, risperidone and older antipsychotics. METHOD We conducted a content analysis of an Internet database of comments about prescribed medications. RESULTS We analysed 223 comments on risperidone, 170 on olanzapine and 46 relating to three older antips... | ACTA PSYCHIATRICA |
{"1011": 0.1685553640127182, "1041": 0.7809720039367676, "1044": 0.12728634476661682, "1049": 0.0913962796330452, "1051": 0.12556517124176025, "1056": 0.2034190446138382, "1059": 1.0933903455734253, "1081": 0.37102460861206055, "2006": 0.23710809648036957, "2033": 0.08513788133859634, "2034": 0.026025565341114998, "207... | 8524891 | OBJECTIVE White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression of Alzheimer's disease (AD). These observations are typically i... | White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network. |
{"1016": 0.4879087805747986, "1051": 0.045809537172317505, "1998": 0.029824240133166313, "2040": 0.2145126610994339, "2044": 0.3810817003250122, "2047": 0.08513788133859634, "2048": 0.27934664487838745, "2062": 0.0009760859538801014, "2071": 0.39367714524269104, "2082": 0.3325583338737488, "2086": 0.2409527748823166, "... | 8529693 | In this paper we review the associations between maternal and child undernutrition with human capital and risk of adult diseases in low-income and middle-income countries. We analysed data from five long-standing prospective cohort studies from Brazil, Guatemala, India, the Philippines, and South Africa and noted that ... | Maternal and child undernutrition: consequences for adult health and human capital |
{"1011": 0.20977331697940826, "1040": 0.06612417846918106, "1041": 0.16276304423809052, "1054": 0.8837352395057678, "1057": 0.53589928150177, "1996": 0.17020416259765625, "2003": 0.0770333781838417, "2008": 0.14518201351165771, "2011": 0.46608972549438477, "2013": 0.12556517124176025, "2029": 0.2105647772550583, "2039"... | 8533245 | The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled proteins from the ER to the proteasome. Still, however, little is known about the components mediating ERAD of membrane proteins. Here we show that the evolutionary conserved rhomboid f... | Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins. |
{"1001": 0.28743788599967957, "1041": 0.011650617234408855, "1050": 0.40546512603759766, "1051": 0.2749055027961731, "1997": 0.1946154683828354, "1999": 0.25088030099868774, "2001": 0.13071982562541962, "2004": 0.06337817758321762, "2005": 0.08603433519601822, "2029": 0.16690383851528168, "2034": 0.013579257763922215, ... | 8536018 | Nitric oxide (NO) was identified as a key player in plant defence responses approximately 20 years ago and a large body of evidence has accumulated since then supporting its role as a signalling molecule. However, there are many discrepancies in current NO detection assays and the enzymatic pathways responsible for its... | Detection and function of nitric oxide during the hypersensitive response in Arabidopsis thaliana: where there's a will there's a way. |
{"1011": 0.23556606471538544, "1013": 0.040196798741817474, "1038": 0.11256109178066254, "1039": 0.4487839937210083, "1041": 0.15526613593101501, "1052": 0.2954642176628113, "1996": 0.055094651877880096, "1997": 0.03831886500120163, "1998": 0.08154398202896118, "1999": 0.1602703034877777, "2006": 0.35403475165367126, "... | 8538916 | The molecular chaperone CCT/TRiC plays a central role in maintaining cellular proteostasis as it mediates the folding of the major cytoskeletal proteins tubulins and actins. CCT/TRiC is also involved in the oncoprotein cyclin E, the Von Hippel-Lindau tumour suppressor protein, cyclin B and p21(ras) folding which strong... | The Cytosolic Chaperonin CCT/TRiC and Cancer Cell Proliferation |
{"1011": 0.034552380442619324, "1017": 0.28450319170951843, "1018": 0.10906458646059036, "1039": 0.36290550231933594, "1044": 0.6170841455459595, "1048": 0.3784096837043762, "1997": 0.11865071207284927, "2002": 0.04394211992621422, "2005": 0.0770333781838417, "2008": 0.02792670577764511, "2010": 1.1549384593963623, "20... | 8548635 | Methylation of histones has been regarded as a stable modification defining the epigenetic program of the cell, which regulates chromatin structure and transcription. However, the recent discovery of histone demethylases has challenged the stable nature of histone methylation. Here we demonstrate that the JARID1 protei... | RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3 |
{"1996": 0.35813871026039124, "2024": 0.1401015669107437, "2025": 0.1358480453491211, "2029": 0.10555581003427505, "2035": 0.4067663550376892, "2038": 0.045809537172317505, "2052": 0.28670501708984375, "2054": 0.2837681770324707, "2055": 0.011650617234408855, "2071": 0.2184450328350067, "2073": 0.1889725625514984, "207... | 8551160 | Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predictable set of defe... | Mitochondria: Dynamic Organelles in Disease, Aging, and Development |
{"1009": 0.8366385698318481, "1011": 0.39893341064453125, "1015": 0.5528968572616577, "1016": 0.6502478122711182, "1017": 0.46853771805763245, "1018": 0.20102575421333313, "1022": 0.1808556467294693, "1039": 0.5579402446746826, "1056": 0.7629209756851196, "1998": 0.0058422754518687725, "2002": 0.08603433519601822, "200... | 8563659 | To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV-2 lesions from patients on and off antiviral therapy. CD4(+) and CD8(+) T cells and a mixed population of plasmacytoid and my... | Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition |
{"1014": 0.09228714555501938, "1039": 0.30486753582954407, "1044": 0.13925230503082275, "1056": 0.16607704758644104, "2007": 0.13243216276168823, "2039": 0.26296505331993103, "2043": 0.02792670577764511, "2048": 0.24248650670051575, "2051": 0.31132611632347107, "2058": 0.7380234599113464, "2084": 0.07884006202220917, "... | 8570317 | We conducted a two-stage population-based headache survey among subjects aged > or = 15 in Taipei, Taiwan. Subjects with chronic daily headache (CDH) in the past year were identified, interviewed and followed-up. CDH was defined as a headache frequency > 15 days/month, with a duration > 4 h/day. Of the 3377 participant... | Chronic daily headache in Taipei, Taiwan: prevalence, follow-up and outcome predictors. |
{"1011": 0.5057345628738403, "1020": 0.06154331564903259, "1038": 0.5016035437583923, "1156": 0.6950984001159668, "1997": 0.07341018319129944, "1999": 0.07159364968538284, "2003": 0.26296505331993103, "2004": 0.055094651877880096, "2008": 0.014542185701429844, "2011": 0.36494144797325134, "2013": 0.18248429894447327, "... | 8570478 | beta-Tubulin is encoded in the genomes of higher animals by a small multigene family comprising approximately seven functional genes. These genes produce a family of closely related, but distinct polypeptide isotypes that are distinguished principally by sequences within the approximately 15 carboxy-terminal amino acid... | In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens |
{"1006": 0.004870930220931768, "1007": 0.034552380442619324, "1018": 0.22079704701900482, "1039": 0.04487626627087593, "1043": 0.3269403576850891, "1052": 0.5051454305648804, "1053": 0.7144040465354919, "1157": 0.39696553349494934, "1998": 0.010684899985790253, "1999": 0.06154331564903259, "2003": 0.026025565341114998,... | 8570690 | INTRODUCTION Topiramate (TOP) blocks glutamate receptors and facilitates GABA (γ-aminobutyric acid) neurotransmission, effects that may facilitate smoking cessation. We compared the effects of behavioral counseling combined with (a) TOP, (b) TOP/nicotine patch (TOP/NIC), or (c) placebo (PLC) for smoking cessation. METH... | Topiramate for smoking cessation: a randomized, placebo-controlled pilot study. |
{"1011": 0.40806588530540466, "1038": 0.37371641397476196, "1054": 0.13243216276168823, "2003": 0.1734936386346817, "2005": 0.0058422754518687725, "2029": 0.1889725625514984, "2036": 0.2018241584300995, "2075": 0.04860413447022438, "2076": 0.45870962738990784, "2079": 0.1510767638683319, "2099": 1.3769737482070923, "21... | 8577229 | Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechanism to repair double-strand chromosome breaks in eukaryotes. This mechanism appears to be c... | Break-induced DNA replication. |
{"1022": 0.3916989266872406, "1023": 0.02412080205976963, "1051": 0.5461324453353882, "1057": 0.5324648022651672, "1061": 1.17624831199646, "1997": 0.2954642176628113, "2001": 0.13243216276168823, "2004": 0.0317181795835495, "2011": 0.0019512200960889459, "2012": 0.08961215615272522, "2015": 0.43244171142578125, "2020"... | 8582337 | IMPORTANCE Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. OBJECTIVES To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measurements with tho... | The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. |
{"1003": 0.31132611632347107, "1050": 0.30486753582954407, "1058": 1.004473328590393, "2001": 0.06429435312747955, "2004": 0.026025565341114998, "2005": 0.08603433519601822, "2007": 0.0174254160374403, "2011": 0.06337817758321762, "2012": 0.12642613053321838, "2020": 0.12556517124176025, "2029": 0.0842406153678894, "20... | 8593263 | An observational prospective cohort study assessed malaria risk perception, knowledge and prophylaxis practices among individuals of African ethnicity living in Paris and travelling to their country of origin to visit friends or relatives (VFR). The study compared two groups of VFR who had visited a travel clinic (TC; ... | Malaria risk perception, knowledge and prophylaxis practices among travellers of African ethnicity living in Paris and visiting their country of origin in sub-Saharan Africa. |
{"1011": 0.05970508232712746, "1014": 0.40351006388664246, "1021": 0.1946154683828354, "1042": 0.8195732831954956, "1048": 0.12642613053321838, "2007": 0.0058422754518687725, "2020": 0.0019512200960889459, "2029": 0.07431721687316895, "2038": 0.09317722171545029, "2042": 0.1332872211933136, "2063": 0.00875066313892603,... | 8595678 | BACKGROUND The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previous overview showed that the effects were greatest in regions with low dietary folate consumption, but differentiation between the effect of folate and small-study bias was difficult.... | Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials |
{"1016": 0.4891071021556854, "1020": 0.24859806895256042, "1021": 0.01934296265244484, "1040": 0.38308101892471313, "1052": 0.2160874605178833, "1056": 0.8425432443618774, "1155": 0.19782574474811554, "1997": 0.006812678650021553, "2003": 0.07793712615966797, "2007": 0.19622190296649933, "2011": 0.4196864068508148, "20... | 8596357 | Functional disruption of dendritic cells (DC) is an important strategy for viral pathogens to evade host defences. In this context, porcine circovirus type 2 (PCV2), a single-stranded DNA virus, impairs plasmacytoid DC (pDC) and conventional DC activation by certain viruses or Toll-like receptor (TLR) ligands. This inh... | Porcine circovirus type 2 DNA influences cytoskeleton rearrangements in plasmacytoid and monocyte-derived dendritic cells. |
{"1009": 0.8731874823570251, "1014": 0.07068414986133575, "1044": 0.619189441204071, "1050": 0.07612881064414978, "1052": 0.28670501708984375, "1081": 0.7182208299636841, "1158": 0.17020416259765625, "1998": 0.176772341132164, "2007": 0.2749055027961731, "2012": 0.22782009840011597, "2020": 0.04113444685935974, "2042":... | 8596837 | Women with a history of hypertensive pregnancy are at greater risk for future cardiovascular events; however, the mechanisms for this increased risk are unknown. Evidence suggests that an exercise stimulus unmasks latent hypertensive tendencies, identifying individuals at the greatest risk for developing cardiovascular... | Sympathetic neural and cardiovascular responses during static handgrip exercise in women with a history of hypertensive pregnancy |
{"1011": 0.2852376699447632, "1048": 0.14264501631259918, "1998": 0.2409527748823166, "2004": 0.2034190446138382, "2044": 0.40546512603759766, "2064": 0.3683255612850189, "2071": 0.14686977863311768, "2090": 0.28890204429626465, "2092": 0.009718249551951885, "2109": 0.2652147710323334, "2119": 0.19381128251552582, "214... | 8604837 | Stress-induced immunological reactions to exercise have stimulated much research into stress immunology and neuroimmunology. It is suggested that exercise can be employed as a model of temporary immunosuppression that occurs after severe physical stress. The exercise-stress model can be easily manipulated experimentall... | Exercise and the immune system: regulation, integration, and adaptation. |
{"1011": 0.18248429894447327, "1015": 0.7047978043556213, "1035": 0.07159364968538284, "1038": 0.6911921501159668, "1048": 0.5232481360435486, "1052": 0.8083226680755615, "1996": 0.175953671336174, "2011": 0.1913948506116867, "2026": 0.53589928150177, "2028": 0.26146242022514343, "2029": 0.23092569410800934, "2049": 0.... | 8610932 | Regulatory gene circuits with positive-feedback loops control stem cell differentiation, but several mechanisms can contribute to positive feedback. Here, we dissect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and myeloid differentiation. Quantitative live-cell imaging revealed tha... | Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. |
{"1011": 0.31560876965522766, "1015": 0.417115718126297, "1016": 0.38041436672210693, "1038": 1.2318994998931885, "1042": 0.7276995778083801, "1049": 0.5822374224662781, "1996": 0.09228714555501938, "2007": 0.034552380442619324, "2008": 0.02412080205976963, "2013": 0.07068414986133575, "2015": 0.08064348995685577, "202... | 8629328 | Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B c... | Peripheral B cell subsets. |
{"1009": 0.33115679025650024, "1011": 0.472198486328125, "1015": 0.5461324453353882, "1016": 0.36494144797325134, "1018": 0.27044451236724854, "1019": 0.30558720231056213, "1023": 0.0354953333735466, "1044": 0.36426326632499695, "1056": 0.7701805830001831, "1058": 0.35128939151763916, "1998": 0.11168810725212097, "1999... | 8639034 | IL-10 gene transcription and IL-10 protein production was assessed in both type 1 (Th1) and type 2 (Th2) CD4+ human T cell clones by polymerase chain reaction and ELISA, respectively. Although Th2 clones apparently showed higher IL-10 mRNA levels, IL-10 mRNA expression was consistently found in Th1 clones, as well. Lik... | Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. |
{"1011": 0.3560888469219208, "1037": 0.27786844968795776, "1039": 0.016465263441205025, "1041": 0.036437395960092545, "1042": 0.38441169261932373, "1043": 0.777387797832489, "1044": 0.0058422754518687725, "1051": 0.6902132034301758, "1055": 0.7286425232887268, "2000": 0.00875066313892603, "2005": 0.025073638185858727, ... | 8642784 | OBJECTIVE To assess the efficacy of various controlled ovarian hyperstimulation (COH) regimens in the prior poor-responder patient preparing for assisted reproductive techniques. DESIGN English-language literature review. PATIENT(S) Candidates for assisted reproductive techniques who had been defined as having a prior ... | Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques. |
{"1006": 0.09406650811433792, "1011": 0.5139457583427429, "1050": 0.9591107368469238, "1052": 0.7610978484153748, "1060": 0.6038249135017395, "1997": 0.056018441915512085, "2003": 0.2689530849456787, "2004": 0.19381128251552582, "2005": 0.151916041970253, "2044": 0.05139094591140747, "2052": 0.06612417846918106, "2064"... | 8646760 | Protein modifications play a major role for most biological processes in living organisms. Amino-terminal acetylation of proteins is a common modification found throughout the tree of life: the N-terminus of a nascent polypeptide chain becomes co-translationally acetylated, often after the removal of the initiating met... | Identification and Functional Characterization of N-Terminally Acetylated Proteins in Drosophila melanogaster |
{"1011": 0.025073638185858727, "1017": 0.04113444685935974, "1020": 0.03266380727291107, "1038": 0.45251765847206116, "1039": 0.5301685929298401, "1041": 0.5618454217910767, "1044": 0.5450005531311035, "1048": 0.4673144817352295, "1049": 0.18816383183002472, "1052": 0.7809720039367676, "1058": 0.35403475165367126, "199... | 8654183 | BACKGROUND AND AIMS Previous in vitro and in vivo studies have revealed an association between Helicobacter pylori infection and apoptosis in gastric epithelial cells. Although involvement of the Bcl-2 family of proteins as well as cytochrome c release has been demonstrated in H pylori induced cell death, the exact rol... | Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori. |
{"2003": 0.3141832649707794, "2033": 0.4374985992908478, "2047": 0.4512746334075928, "2054": 0.030771657824516296, "2064": 0.17840765416622162, "2075": 0.06703783571720123, "2077": 0.3077431619167328, "2079": 0.03925827145576477, "2085": 0.0913962796330452, "2109": 0.4067663550376892, "2121": 0.28890204429626465, "2220... | 8659426 | Cancer chemoprevention involves the chronic administration of a synthetic, natural or biological agent to reduce or delay the occurrence of malignancy. The potential value of this approach has been demonstrated with trials in breast, prostate and colon cancer. The paradigm for developing new chemopreventive agents has ... | Cancer chemoprevention: a rapidly evolving field |
{"1015": 0.40481385588645935, "1018": 0.5092619061470032, "1040": 0.08961215615272522, "2001": 0.3283478021621704, "2013": 0.5805994272232056, "2015": 0.28890204429626465, "2020": 0.2881702482700348, "2029": 0.053244512528181076, "2034": 0.5209306478500366, "2038": 0.11430477350950241, "2042": 0.2607102394104004, "2043... | 8665891 | Dengue virus and its four serotypes (DENV 1-4) infect approximately 390 million people worldwide each year, with most cases in tropical and subtropical regions. Because of repeated introduction of DENV from epidemic regions and suitable weather conditions, many regions have shifted from hypo-endemicity to hyper-endemic... | Dengue is still an imported disease in China: a case study in Guangzhou. |
{"1018": 0.15359249711036682, "1041": 0.14095009863376617, "2003": 0.13499516248703003, "2109": 0.43623676896095276, "2120": 0.6218147873878479, "2129": 0.10203468054533005, "2176": 0.5010119676589966, "2224": 0.34370049834251404, "2236": 0.6170841455459595, "2291": 0.011650617234408855, "2313": 0.306306391954422, "233... | 8670178 | This paper describes the Estimation and Projection Package (EPP) for estimating and projecting HIV prevalence levels in countries with generalised epidemics. The paper gives an overall summary of the software and interface. It describes the process of defining and modelling a national epidemic in terms of locally relev... | The UNAIDS Estimation and Projection Package: a software package to estimate and project national HIV epidemics. |
{"1011": 0.5433003902435303, "1019": 0.18004031479358673, "1041": 0.5232481360435486, "1045": 0.3374483287334442, "2003": 0.14686977863311768, "2006": 0.16359257698059082, "2008": 0.04113444685935974, "2011": 0.056018441915512085, "2029": 0.13755162060260773, "2030": 0.23633737862110138, "2064": 0.09584271162748337, "2... | 8671456 | BACKGROUND Interleukin-24 (IL-24) is a cytokine that belongs to the IL-10 family. It can selectively induce cancer cell apoptosis which has been utilized as a cancer gene therapy strategy. METHODS A recombinant type five adenovirus containing IL-24 gene (designated CNHK600-IL24) was constructed, whose replication is ac... | Oncolytic adenovirus armed with IL-24 Inhibits the growth of breast cancer in vitro and in vivo |
{"1003": 0.053244512528181076, "1014": 0.14518201351165771, "1044": 0.12728634476661682, "1050": 0.34577593207359314, "1052": 0.22937409579753876, "1999": 0.6296497583389282, "2007": 0.4374985992908478, "2012": 0.46853771805763245, "2031": 0.053244512528181076, "2058": 0.04207121208310127, "2087": 0.04394211992621422, ... | 8672737 | BACKGROUND AND PURPOSE Migraineurs are at increased risk of cerebellar infarcts and supratentorial white matter lesions. The prevalence, frequency, and distribution of infratentorial hyperintense lesions in migraine are unknown. METHODS Migraineurs with aura (n=161), without aura (n=134), and controls (n=140) from a po... | Brain stem and cerebellar hyperintense lesions in migraine. |
{"1011": 0.38308101892471313, "1014": 0.3134697377681732, "1015": 0.5805994272232056, "1017": 0.306306391954422, "1021": 0.14095009863376617, "1043": 0.32341301441192627, "1050": 0.9515975713729858, "1054": 0.1946154683828354, "1060": 0.45251765847206116, "1156": 0.7408206462860107, "2002": 0.7969439625740051, "2004": ... | 8677721 | The N-myc downstream regulated gene 1 (NDRG1) is significantly associated with advanced tumor stages and poor survival of hepatocellular carcinoma (HCC), thereby implicating it as a potential target for HCC treatment. We aim to further understand its biological roles in hepatocarcinogenesis, as a means to exploit it fo... | NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3β and Nur77 to prevent β-catenin degradation |
{"1011": 0.08154398202896118, "1055": 0.7124901413917542, "2000": 0.18411032855510712, "2005": 0.15943801403045654, "2028": 0.043007105588912964, "2029": 0.19381128251552582, "2045": 0.3485364317893982, "2050": 0.14939609169960022, "2087": 0.2034190446138382, "2109": 0.18248429894447327, "2111": 0.13157635927200317, "2... | 8690595 | Although genetic association studies have been with us for many years, even for the simplest analyses there is little consensus on the most appropriate statistical procedures. Here I give an overview of statistical approaches to population association studies, including preliminary analyses (Hardy–Weinberg equilibrium ... | A tutorial on statistical methods for population association studies |
{"1011": 0.018384648486971855, "1022": 0.3269403576850891, "1038": 0.6054253578186035, "1039": 0.10993985831737518, "1041": 0.44753631949424744, "1044": 0.6054253578186035, "1057": 0.3683255612850189, "2002": 0.7124901413917542, "2003": 0.015504186972975731, "2004": 0.0842406153678894, "2005": 0.06977381557226181, "200... | 8692744 | Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate immune responses. In order to identify TRIM proteins that modulat... | Identification and Characterization of Multiple TRIM Proteins That Inhibit Hepatitis B Virus Transcription |
{"1011": 0.013579257763922215, "1054": 0.5483922958374023, "1055": 0.14264501631259918, "1056": 0.48068851232528687, "1060": 0.4909018874168396, "2003": 0.3560888469219208, "2015": 0.33953672647476196, "2033": 0.9123768210411072, "2043": 0.1358480453491211, "2063": 0.018384648486971855, "2077": 0.1718502640724182, "208... | 8698208 | Rett syndrome (RTT) is an inherited neurodevelopmental disorder of females that occurs once in 10,000–15,000 births. Affected females develop normally for 6–18 months, but then lose voluntary movements, including speech and hand skills. Most RTT patients are heterozygous for mutations in the X-linked gene MECP2 (refs. ... | A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome |
{"1011": 0.17431432008743286, "1013": 0.0009760859538801014, "1042": 0.2478361576795578, "1052": 0.5092619061470032, "1054": 0.5805994272232056, "1056": 0.4248080551624298, "1999": 0.11081436276435852, "2008": 0.0019512200960889459, "2011": 0.42799583077430725, "2012": 0.32341301441192627, "2024": 0.16607704758644104, ... | 8698857 | TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF. We demonstrate that translation of the TNF-precursor at the ER requir... | The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation |
{"1011": 0.33953672647476196, "1015": 0.15442965924739838, "1016": 0.1808556467294693, "1041": 0.036437395960092545, "1044": 0.10555581003427505, "1049": 0.0606246218085289, "1164": 0.4425300657749176, "2003": 0.06337817758321762, "2004": 0.11430477350950241, "2005": 0.22859740257263184, "2011": 0.2881702482700348, "20... | 8702697 | AIMS Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. We have recently demonstrated that cancer-associated fibroblasts (CAFs) elicit a redox-dependent epithelial-mesenchymal transition (EMT) in prostate cancer (PCa) cells, driven by cycloxygenase-2/hypoxia-indu... | miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts. |
{"1003": 0.06429435312747955, "1016": 0.8559102416038513, "1040": 0.013579257763922215, "1056": 0.8837352395057678, "1057": 0.01934296265244484, "2000": 0.22079704701900482, "2005": 0.2409527748823166, "2011": 0.08064348995685577, "2048": 0.4574742913246155, "2062": 0.03831886500120163, "2064": 0.3784096837043762, "207... | 8708082 | Type 2 diabetes mellitus (T2DM) affects more than 7% of adults in the US and leads to substantial personal and economic burden. In prediabetic states insulin secretion and action—potential targets of preventive interventions—are impaired. In trials lifestyle modification (i.e. weight loss and exercise) has proven effec... | The prevention of type 2 diabetes |
{"1011": 0.10731173306703568, "1017": 0.053244512528181076, "1019": 0.20580662786960602, "1997": 0.06795065850019455, "2013": 0.44566190242767334, "2015": 0.4770587682723999, "2029": 0.10731173306703568, "2045": 0.32553088665008545, "2047": 0.6613984704017639, "2075": 0.24018502235412598, "2116": 0.6911921501159668, "2... | 8712839 | This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promo... | The transcriptional landscape of the mammalian genome. |
{"1038": 0.4512746334075928, "1040": 0.2969166338443756, "1052": 0.6950984001159668, "1997": 0.11168810725212097, "2003": 0.2976420819759369, "2088": 0.1677299439907074, "2225": 0.4337083101272583, "2291": 0.23402166366577148, "2309": 0.45499902963638306, "2338": 0.09228714555501938, "2378": 0.3519764244556427, "2391":... | 8721150 | The Protein Data Bank [PDB; Berman, Westbrook et al. (2000), Nucleic Acids Res. 28, 235-242; http://www.pdb.org/] is the single worldwide archive of primary structural data of biological macromolecules. Many secondary sources of information are derived from PDB data. It is the starting point for studies in structural b... | The Protein Data Bank |
{"1043": 0.7086513638496399, "1044": 0.20022670924663544, "1048": 0.18329764902591705, "1052": 0.7881022095680237, "2002": 0.17020416259765625, "2005": 0.12642613053321838, "2011": 0.15777134895324707, "2025": 0.3850763738155365, "2029": 0.24018502235412598, "2035": 0.2184450328350067, "2064": 0.018384648486971855, "20... | 8724666 | The balance between oxidative and nonoxidative glucose metabolism is essential for a number of pathophysiological processes. By deleting enzymes that affect aerobic glycolysis with different potencies, we examine how modulating glucose metabolism specifically affects hematopoietic and leukemic cell populations. We find... | Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis |
{"1011": 0.5404602885246277, "1043": 0.3588210940361023, "1051": 0.2493593990802765, "1053": 0.1970241367816925, "2003": 0.13925230503082275, "2015": 0.24859806895256042, "2019": 0.6754127144813538, "2029": 0.06337817758321762, "2043": 0.0354953333735466, "2048": 0.07341018319129944, "2049": 0.00875066313892603, "2061"... | 8734695 | Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial e... | A transition in brain state during propofol-induced unconsciousness. |
{"1011": 0.18004031479358673, "1018": 0.2561853528022766, "1055": 0.07341018319129944, "1997": 0.1485546976327896, "2007": 0.03266380727291107, "2011": 0.2852376699447632, "2029": 0.030771657824516296, "2034": 0.053244512528181076, "2037": 0.06246116757392883, "2047": 0.05694137513637543, "2076": 0.6769026517868042, "2... | 8747771 | Duplication and segregation of chromosomes involves dynamic reorganization of their internal structure by conserved architectural proteins, including the structural maintenance of chromosomes (SMC) complexes cohesin and condensin. Despite active investigation of the roles of these factors, a genome-wide view of dynamic... | Cohesins and condensins orchestrate the 4D dynamics of yeast chromosomes during the cell cycle |
{"1037": 0.18654440343379974, "1044": 0.6054253578186035, "2002": 1.0881409645080566, "2003": 0.17431432008743286, "2008": 0.018384648486971855, "2013": 0.472198486328125, "2015": 0.0058422754518687725, "2016": 0.010684899985790253, "2020": 0.02316705882549286, "2024": 0.45623743534088135, "2029": 0.04394211992621422, ... | 8748720 | The Heliconius butterflies are a diverse recent radiation comprising multiple levels of divergence with ongoing gene flow between species. The recently sequenced genome of Heliconius melpomene allowed us to investigate the genomic evolution of this group using dense RAD marker sequencing. Phylogenetic analysis of 54 in... | Genome-wide patterns of divergence and gene flow across a butterfly radiation. |
{"1014": 0.28963330388069153, "1017": 0.29981520771980286, "1041": 0.11517547070980072, "1056": 0.18573370575904846, "2004": 0.10906458646059036, "2005": 0.5893046259880066, "2006": 0.012615402229130268, "2029": 0.03925827145576477, "2033": 0.8298473954200745, "2034": 0.2447827309370041, "2043": 0.025073638185858727, "... | 8756719 | This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis. In a randomized (3:1), double-blinded study, Australian soldiers received weekly malaria prophylaxis with 200 mg tafenoquine (492 subjects) or 250 mg mefloquine (162 subjects) for 6 mon... | Randomized, double-blind study of the safety, tolerability, and efficacy of tafenoquine versus mefloquine for malaria prophylaxis in nonimmune subjects. |
{"2043": 0.27786844968795776, "2051": 0.8805016279220581, "2073": 0.0009760859538801014, "2076": 0.440646231174469, "2079": 0.053244512528181076, "2116": 0.2501201331615448, "2129": 0.09672962874174118, "2146": 0.1710275560617447, "2220": 0.5069117546081543, "2287": 0.08244366943836212, "2335": 0.6022219061851501, "233... | 8759633 | Studies of replication timing provide a handle into previously impenetrable higher-order levels of chromosome organization and their plasticity during development. Although mechanisms regulating replication timing are not clear, novel genome-wide studies provide a thorough survey of the extent to which replication timi... | Domain-wide regulation of DNA replication timing during mammalian development |
{"1011": 0.23864774405956268, "1015": 0.19622190296649933, "1039": 0.29981520771980286, "1048": 0.1221139207482338, "2005": 0.2409527748823166, "2007": 0.2830325961112976, "2011": 0.1677299439907074, "2015": 0.0770333781838417, "2026": 0.5811457633972168, "2029": 0.08064348995685577, "2036": 0.29981520771980286, "2057"... | 8764879 | Leukemias and other cancers possess self-renewing stem cells that help to maintain the cancer. Cancer stem cell eradication is thought to be crucial for successful anticancer therapy. Using an acute myeloid leukemia (AML) model induced by the leukemia-associated monocytic leukemia zinc finger (MOZ)-TIF2 fusion protein,... | PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2 |
{"1009": 0.24018502235412598, "1042": 0.6897233724594116, "1050": 0.18167030811309814, "1155": 0.1212492436170578, "2011": 0.31560876965522766, "2026": 0.7583568692207336, "2029": 0.1905880719423294, "2033": 0.6096806526184082, "2064": 0.18167030811309814, "2076": 0.5668440461158752, "2079": 0.1011524572968483, "2361":... | 8771704 | Acute skeletal muscle injury triggers an expansion of fibro/adipogenic progenitors (FAPs) and a transient stage of fibrogenesis characterized by extracellular matrix deposition. While the perpetuation of such phase can lead to permanent tissue scarring, the consequences of its suppression remain to be studied. Using a ... | Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration. |
{"1011": 0.15359249711036682, "1017": 0.07068414986133575, "1040": 0.2696990668773651, "1997": 0.011650617234408855, "1999": 0.10026945173740387, "2006": 0.13925230503082275, "2008": 0.05417001247406006, "2011": 0.3005385100841522, "2029": 0.23864774405956268, "2076": 0.49030399322509766, "2079": 0.3262358605861664, "2... | 8774475 | Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during tumorigenesis is not well understood. Here, we demonstrate that depletion of Scribble in mammary epithelia disrupts cell polarity, blocks three... | Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma |
{"1014": 0.21293537318706512, "1018": 0.07159364968538284, "1020": 0.08244366943836212, "1022": 0.05139094591140747, "1023": 0.18411032855510712, "1052": 0.32764431834220886, "1999": 0.03360854089260101, "2000": 0.28082266449928284, "2001": 0.1693800985813141, "2005": 0.40611594915390015, "2007": 0.14264501631259918, "... | 8780599 | OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls. The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal. METHODS Data on the i... | The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%. |
{"1011": 0.11691460013389587, "1015": 0.42096930742263794, "1039": 0.6011518239974976, "1043": 0.32764431834220886, "1044": 0.40285754203796387, "1045": 0.5174443125724792, "1055": 0.29981520771980286, "1060": 0.3248254358768463, "2005": 0.22157983481884003, "2007": 0.012615402229130268, "2011": 0.2034190446138382, "20... | 8790729 | BACKGROUND There is a widespread interest in developing renewable sources of islet-replacement tissue for type I diabetes mellitus. Human mesenchymal cells isolated from the Wharton's jelly of the umbilical cord (HUMSCs), which can be easily obtained and processed compared with embryonic and bone marrow stem cells, pos... | Islet-Like Clusters Derived from Mesenchymal Stem Cells in Wharton's Jelly of the Human Umbilical Cord for Transplantation to Control Type 1 Diabetes |
{"1003": 0.3870677351951599, "1019": 0.562402069568634, "1020": 0.7809720039367676, "1044": 0.37907835841178894, "1998": 0.021256839856505394, "1999": 0.1384023278951645, "2002": 0.16276304423809052, "2007": 0.12470348179340363, "2029": 0.04953393340110779, "2060": 0.06337817758321762, "2064": 0.045809537172317505, "20... | 8814634 | OBJECTIVE To determine whether the perioperative use of hydroxyethyl starch 6% and albumin 5% in elective joint arthroplasties are associated with an increased risk for perioperative complications. DESIGN Retrospective cohort study of population based data between 2006 and 2013. SETTING Data from 510 different hospital... | Use of perioperative hydroxyethyl starch 6% and albumin 5% in elective joint arthroplasty and association with adverse outcomes: a retrospective population based analysis |
{"1015": 0.3615458607673645, "1017": 0.16442140936851501, "1038": 1.0285027027130127, "1043": 0.5151132941246033, "1044": 0.09850110858678818, "1998": 0.1619328260421753, "1999": 0.04113444685935974, "2004": 0.5849615335464478, "2007": 0.036437395960092545, "2008": 0.0038986403960734606, "2011": 0.25239890813827515, "2... | 8816869 | Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 ... | BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis |
{"1043": 0.6773988008499146, "2011": 0.15526613593101501, "2038": 0.14349138736724854, "2042": 0.25467249751091003, "2045": 0.07793712615966797, "2064": 0.09495500475168228, "2071": 0.052318159490823746, "2089": 0.12728634476661682, "2091": 0.10906458646059036, "2094": 0.0842406153678894, "2106": 0.020300358533859253, ... | 8839502 | The incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem. While genetic factors contribute to susceptibility and progression of renal disease, proteinuria has been claimed as an independent predictor of outcome. Reduction of urinary protein lev... | Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. |
{"1014": 0.5301685929298401, "1015": 0.7987030148506165, "1016": 0.5381823778152466, "1017": 0.1751343309879303, "1018": 0.23864774405956268, "1019": 0.06703783571720123, "1020": 0.10291612148284912, "1021": 0.39893341064453125, "1022": 0.13071982562541962, "1040": 0.5272908806800842, "1043": 0.4679262638092041, "1045"... | 8842332 | OBJECTIVE To compare contemporary pregnancy outcomes in women with and without type 1 diabetes, and to examine the effects of obesity and glycaemic control on these outcomes. DESIGN AND SETTING Historical cohort study in a specialist diabetes and maternity network in Victoria. PARTICIPANTS All singleton births (at leas... | Contemporary type 1 diabetes pregnancy outcomes: impact of obesity and glycaemic control. |
{"1011": 0.055094651877880096, "1015": 0.1229778528213501, "1017": 0.10467668622732162, "1038": 0.2394166737794876, "1040": 1.2364475727081299, "1047": 0.3956514894962311, "1054": 0.7134475708007812, "1055": 0.32764431834220886, "1058": 1.070887804031372, "1059": 0.14518201351165771, "1060": 0.4926934838294983, "1997":... | 8856690 | The hormonal metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR). When occupied by 1,25D, VDR interacts with the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly ... | Molecular Mechanisms of Vitamin D Action |
{"1011": 0.04674193635582924, "1044": 0.21135559678077698, "1053": 1.4056373834609985, "1056": 0.2026219218969345, "1998": 0.12986256182193756, "2002": 0.08961215615272522, "2003": 0.12038381397724152, "2029": 0.11343330889940262, "2046": 0.08871890604496002, "2051": 0.4330752193927765, "2071": 0.15943801403045654, "20... | 8858602 | A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction. We developed a proteomic technique called "quantitative temporal viromics" (QTV), which employs multiplexed tandem-mass-tag-based ... | Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction |
{"1016": 0.603290855884552, "1043": 0.53589928150177, "1044": 0.24248650670051575, "1051": 0.25239890813827515, "2003": 0.06337817758321762, "2004": 0.013579257763922215, "2042": 0.13243216276168823, "2048": 0.13670019805431366, "2050": 0.09495500475168228, "2061": 0.09761575609445572, "2064": 0.3916989266872406, "2065... | 8868863 | Sleep disturbances, including sleep insufficiency and sleep fragmentation, have been linked to abnormal glucose metabolism and increased diabetes risk. Well-controlled laboratory studies have provided insights regarding the underlying mechanisms. Several large prospective studies suggest that these sleep disturbances a... | Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes. |
{"1009": 0.1485546976327896, "1011": 0.1873544454574585, "1015": 0.7647408246994019, "1017": 0.2394166737794876, "1018": 0.19381128251552582, "1019": 0.0842406153678894, "1043": 0.472198486328125, "1050": 0.2918238639831543, "1056": 0.2719337046146393, "2000": 0.11865071207284927, "2005": 0.1734936386346817, "2011": 0.... | 8883846 | The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses. The goals of this workshop were to identify key scientific issues, gaps, and oppor... | Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions |
{"1011": 0.05694137513637543, "1039": 0.2247048318386078, "1041": 0.26296505331993103, "2003": 0.04113444685935974, "2024": 0.129004567861557, "2031": 0.176772341132164, "2038": 0.06886265426874161, "2039": 0.37707099318504333, "2045": 0.5057345628738403, "2054": 0.053244512528181076, "2064": 0.14433705806732178, "2066... | 8891333 | Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with ‘stem cell’ characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal stem cells and have been termed ‘cancer stem cells’. These cancer stem... | Targeted therapy for cancer stem cells: the patched pathway and ABC transporters |
{"1037": 0.5186077356338501, "1038": 0.3897167444229126, "1044": 0.1358480453491211, "1055": 0.14518201351165771, "1156": 0.6430866718292236, "2011": 0.35403475165367126, "2029": 0.24325250089168549, "2046": 0.25845035910606384, "2058": 0.7845434546470642, "2078": 0.022212404757738113, "2084": 0.09495500475168228, "209... | 8892905 | Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulated to result from increased production of Aβ42 compared to Aβ40 in the central nervous system (CNS).... | Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. |
{"1011": 0.4248080551624298, "1048": 0.1619328260421753, "1054": 0.18004031479358673, "1056": 1.1744394302368164, "1160": 0.7836518287658691, "1996": 0.13925230503082275, "1997": 0.12986256182193756, "1999": 0.03360854089260101, "2007": 0.39762192964553833, "2008": 0.14939609169960022, "2011": 0.39367714524269104, "201... | 8903143 | The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3ε binds to the plasma membrane through a basic residue-rich... | Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling. |
{"1014": 0.1602703034877777, "1052": 0.17020416259765625, "1999": 0.016465263441205025, "2000": 0.12986256182193756, "2001": 0.09495500475168228, "2015": 0.20580662786960602, "2018": 0.015504186972975731, "2020": 0.18654440343379974, "2031": 0.0606246218085289, "2038": 0.42161011695861816, "2042": 0.32270604372024536, ... | 8906858 | BACKGROUND Cali, Colombia, has a high incidence of interpersonal violence deaths. Various alcohol control policies have been implemented to reduce alcohol-related problems. The objective of this study was to determine whether different alcohol control policies were associated with changes in the incidence rate of homic... | Policies for alcohol restriction and their association with interpersonal violence: a time-series analysis of homicides in Cali, Colombia. |
{"1015": 0.23864774405956268, "1020": 0.17020416259765625, "1048": 0.7191727757453918, "1055": 0.8100618124008179, "1999": 0.1477125883102417, "2000": 0.05139094591140747, "2005": 0.1384023278951645, "2011": 0.12814582884311676, "2028": 0.053244512528181076, "2029": 0.14179791510105133, "2058": 0.6759096384048462, "207... | 8909176 | Maltose metabolism of baker's yeast (Saccharomyces cerevisiae) in lean dough is negatively influenced by glucose repression, thereby delaying the dough fermentation. To improve maltose metabolism and leavening ability, it is necessary to alleviate glucose repression. The Snf1 protein kinase is well known to be essentia... | Effects of SNF1 on Maltose Metabolism and Leavening Ability of Baker's Yeast in Lean Dough. |
{"1011": 0.20102575421333313, "1019": 0.3346569836139679, "1040": 0.18248429894447327, "1044": 0.02887592278420925, "1052": 0.5601736903190613, "1053": 0.05046287178993225, "1054": 0.8592242002487183, "2003": 0.3170322775840759, "2011": 0.12814582884311676, "2015": 0.11430477350950241, "2019": 0.6684301495552063, "2024... | 8925851 | Ribosomopathies compose a collection of disorders in which genetic abnormalities cause impaired ribosome biogenesis and function, resulting in specific clinical phenotypes. Congenital mutations in RPS19 and other genes encoding ribosomal proteins cause Diamond-Blackfan anemia, a disorder characterized by hypoplastic, m... | Review article |
{"1011": 0.5849615335464478, "1015": 0.8161250352859497, "1040": 0.6254787445068359, "1048": 1.0478670597076416, "1051": 0.33953672647476196, "1052": 0.8625272512435913, "1056": 0.567951500415802, "2002": 0.6492279767990112, "2003": 0.26296505331993103, "2004": 0.3560888469219208, "2005": 0.14349138736724854, "2008": 0... | 8963413 | PD-L1 is an immunoinhibitory molecule that suppresses the activation of T cells, leading to the progression of tumors. Overexpression of PD-L1 in cancers such as gastric cancer, hepatocellular carcinoma, renal cell carcinoma, esophageal cancer, pancreatic cancer, ovarian cancer, and bladder cancer is associated with po... | PD-L1 expression in human cancers and its association with clinical outcomes |
{"1011": 0.46055975556373596, "1023": 0.03925827145576477, "1044": 0.009718249551951885, "1045": 0.045809537172317505, "1054": 0.8666408061981201, "1999": 0.08513788133859634, "2002": 0.07793712615966797, "2007": 0.1970241367816925, "2008": 0.07068414986133575, "2011": 0.09406650811433792, "2013": 0.40285754203796387, ... | 8979167 | An open reading frame (ORF) with homology to interleukin-10 (IL-10) has been identified in rhesus cytomegalovirus (RhCMV). The IL-10-like protein is generated from a multispliced, polyadenylated early gene transcript encompassing part of the corresponding UL111A ORF of human CMV (HCMV). Immunological analyses confirm e... | Primate cytomegaloviruses encode and express an IL-10-like protein. |
{"1040": 0.27044451236724854, "1056": 0.14602625370025635, "2001": 0.043007105588912964, "2003": 0.2247048318386078, "2011": 0.1905880719423294, "2013": 0.4788752794265747, "2024": 0.12038381397724152, "2034": 0.3163207769393921, "2038": 0.10555581003427505, "2049": 0.14433705806732178, "2061": 0.6054253578186035, "207... | 8989616 | The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequencing, assembly, and annotation of the Tasmanian devil genome and whole-genome sequences for two geog... | Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer |
{"1011": 0.14264501631259918, "1015": 0.2786078155040741, "1017": 0.02792670577764511, "1019": 0.0770333781838417, "1038": 0.021256839856505394, "1044": 0.3269403576850891, "1047": 0.777387797832489, "2004": 0.06612417846918106, "2011": 0.15777134895324707, "2024": 0.12556517124176025, "2028": 0.1229778528213501, "2029... | 8994465 | Melanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within... | A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth |
{"1011": 0.24248650670051575, "1054": 0.05139094591140747, "1999": 0.0317181795835495, "2004": 0.15860503911972046, "2008": 0.03360854089260101, "2011": 0.3248254358768463, "2013": 0.255429208278656, "2015": 0.5057345628738403, "2024": 0.24171993136405945, "2029": 0.1384023278951645, "2033": 0.4654768109321594, "2035":... | 8995263 | Cellular circular RNAs (circRNAs) are generated by head-to-tail splicing and are present in all multicellular organisms studied so far. Recently, circRNAs have emerged as a large class of RNA which can function as post-transcriptional regulators. It has also been shown that many circRNAs are tissue- and stage-specifica... | A map of human circular RNAs in clinically relevant tissues |
{"1011": 0.10203468054533005, "1013": 0.10467668622732162, "1016": 0.14602625370025635, "1017": 0.684319257736206, "1020": 0.24325250089168549, "1055": 0.31560876965522766, "1996": 0.13243216276168823, "1999": 0.09495500475168228, "2007": 0.14686977863311768, "2008": 0.04487626627087593, "2011": 0.37974658608436584, "2... | 8997410 | Recent studies have investigated the dendritic actin cytoskeleton of the cell edge's lamellipodial (LP) region by experimentally decreasing the activity of the actin filament nucleator and branch former, the Arp2/3 complex. Here we extend these studies via pharmacological inhibition of the Arp2/3 complex in sea urchin ... | Arp2/3 complex inhibition radically alters lamellipodial actin architecture, suspended cell shape, and the cell spreading process |
{"1009": 0.6674286723136902, "1011": 0.2561853528022766, "1015": 0.7105726003646851, "1019": 0.39893341064453125, "1022": 0.06337817758321762, "1046": 0.7482418417930603, "1050": 0.5860490798950195, "1056": 0.5557019114494324, "1057": 0.49982786178588867, "1164": 0.24171993136405945, "1999": 0.0752234235405922, "2005":... | 9021186 | The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these cells together with an efficient HAART has been proposed as a... | Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection |
{"1996": 0.23324857652187347, "2003": 0.007782140281051397, "2015": 0.4002431631088257, "2029": 0.036437395960092545, "2037": 0.05139094591140747, "2076": 0.1873544454574585, "2079": 0.35334911942481995, "2119": 0.02316705882549286, "2179": 0.08782484382390976, "2265": 0.46853771805763245, "2298": 0.036437395960092545,... | 9038803 | Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins ... | Centrosome aberrations: cause or consequence of cancer progression? |
{"1011": 0.151916041970253, "1013": 0.176772341132164, "1017": 0.006812678650021553, "1053": 1.3017656803131104, "1054": 0.2852376699447632, "1056": 0.2918238639831543, "1998": 0.0797421783208847, "2007": 0.09761575609445572, "2029": 0.015504186972975731, "2035": 0.02412080205976963, "2043": 0.018384648486971855, "2051... | 9047718 | QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomic... | Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients |
{"1048": 0.4734157919883728, "1998": 0.1485546976327896, "2007": 0.021256839856505394, "2035": 0.7352184057235718, "2039": 0.022212404757738113, "2044": 0.7898768186569214, "2062": 0.1332872211933136, "2076": 0.10203468054533005, "2084": 0.3916989266872406, "2087": 0.27712854743003845, "2102": 0.21293537318706512, "210... | 9056874 | Prolonged or intensive immunosuppressive therapy used after organ transplantation is complicated by an increased incidence of cancer. Striking differences in incidence are observed in heart and heart-lung transplant recipients when compared with renal transplant patients. The most significant increase was in the incide... | Incidence of cancer after immunosuppressive treatment for heart transplantation. |
{"1017": 0.1510767638683319, "1998": 0.02316705882549286, "1999": 0.5415972471237183, "2003": 0.11604541540145874, "2005": 0.10993985831737518, "2011": 0.2447827309370041, "2024": 0.04113444685935974, "2029": 0.13157635927200317, "2045": 0.22937409579753876, "2046": 0.5882205963134766, "2054": 0.12470348179340363, "207... | 9063688 | The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in metastasis, which is the leading cause of death from cancer. Invasive cell migration requires the formation of various structures, such as invadopodia and pseudopodia, which require actin assembly that is regulated by special... | Nucleating actin for invasion |
{"1011": 0.04860413447022438, "1015": 0.23324857652187347, "1041": 0.1677299439907074, "1043": 0.8039615154266357, "1044": 0.29400965571403503, "1998": 0.10026945173740387, "2002": 0.23324857652187347, "2004": 0.06429435312747955, "2005": 0.20022670924663544, "2008": 0.013579257763922215, "2011": 0.22548456490039825, "... | 9076196 | Recent studies have established that during embryonic development, hematopoietic progenitors and stem cells are generated from hemogenic endothelium precursors through a process termed endothelial to hematopoietic transition (EHT). The transcription factor RUNX1 is essential for this process, but its main downstream ef... | GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment. |
{"1011": 0.23633737862110138, "1016": 0.004870930220931768, "1997": 0.2622140049934387, "2003": 0.0752234235405922, "2007": 0.20580662786960602, "2011": 0.40546512603759766, "2015": 0.4425300657749176, "2029": 0.1677299439907074, "2044": 0.2470736801624298, "2048": 0.28743788599967957, "2064": 0.1358480453491211, "2075... | 9091863 | In a diverse group of organisms that includes Caenorhabditis elegans, Drosophila, planaria, hydra, trypanosomes, fungi and plants, the introduction of double-stranded RNAs inhibits gene expression in a sequence-specific manner. These responses, called RNA interference or post-transcriptional gene silencing, may provide... | An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. |
{"1019": 0.35128939151763916, "1047": 1.1561684608459473, "1051": 0.3526630103588104, "1998": 0.0606246218085289, "2004": 0.09228714555501938, "2007": 0.11604541540145874, "2011": 0.08782484382390976, "2020": 0.01934296265244484, "2029": 0.3662964701652527, "2039": 0.17840765416622162, "2043": 0.016465263441205025, "20... | 9095394 | Human epithelium contains keratin, which is expressed during differentiation. Depending on the target cell type, different types of keratin are expressed, and their alterations seem to represent changes in cell properties. The basal cells of oral epithelium express keratin 5 (K5), K14, K15 and K19, but their alteration... | Expression of basal cell keratin 15 and keratin 19 in oral squamous neoplasms represents diverse pathophysiologies. |
{"1011": 0.23556606471538544, "1014": 0.39367714524269104, "1020": 0.5947071313858032, "1026": 0.2719337046146393, "1038": 0.22001366317272186, "1041": 0.2531573474407196, "1050": 0.1718502640724182, "1051": 0.7987030148506165, "1052": 0.31845372915267944, "1056": 0.5517725944519043, "1156": 0.5773153901100159, "1999":... | 9095943 | BACKGROUND In patients with Ovarian Cancer (OvCa) exosomes released by tumor cells are present in the plasma and could be involved in tumor progression. This study examines the association between the exosome presence/protein content in plasma of OvCa patients and disease outcome, response to standard therapy and/or tu... | Exosomes in Plasma of Patients with Ovarian Carcinoma: Potential Biomarkers of Tumor Progression and Response to Therapy. |
{"1048": 0.012615402229130268, "2005": 0.01934296265244484, "2007": 0.29981520771980286, "2037": 0.018384648486971855, "2039": 0.016465263441205025, "2051": 0.1751343309879303, "2053": 0.1994270235300064, "2109": 0.12038381397724152, "2111": 0.3777405619621277, "2114": 0.46608972549438477, "2116": 0.32764431834220886, ... | 9110810 | OBJECTIVE To measure the impact on transmission of leishmaniasis of curtains impregnated with insecticide. DESIGN Cluster randomised controlled trial: household interview survey, observational study of people's behaviour, entomological study with light trap captures of sandflies inside houses. SETTING 14 urban sectors ... | Insecticide impregnated curtains to control domestic transmission of cutaneous leishmaniasis in Venezuela: cluster randomised trial. |
{"1011": 0.3141832649707794, "1040": 0.27934664487838745, "1043": 0.5318912267684937, "1047": 0.9500881433486938, "1052": 0.39367714524269104, "2003": 0.0174254160374403, "2006": 0.5751199722290039, "2008": 0.030771657824516296, "2011": 0.1685553640127182, "2013": 0.1401015669107437, "2029": 0.2501201331615448, "2046":... | 9113824 | Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves somatic activation of K-Ras oncogenes. We report that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and inva... | Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. |
{"1011": 0.06795065850019455, "1017": 0.2018241584300995, "1039": 0.3656192123889923, "1999": 0.3683255612850189, "2002": 0.7067264318466187, "2004": 0.1905880719423294, "2011": 0.37974658608436584, "2013": 0.28890204429626465, "2015": 0.4518963396549225, "2026": 0.7191727757453918, "2042": 0.021256839856505394, "2046"... | 9122283 | RATIONALE Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are direct heart muscle and blood vessel regeneration from transplanted cells, as opposed to paracrine enhancement of tissue preservation and/or recruitment of endogenous repair. OBJECTIVE Human cardi... | Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. |
{"1011": 0.1751343309879303, "1013": 0.12384103983640671, "1042": 0.3241194784641266, "1045": 0.7144040465354919, "1051": 0.6598852276802063, "1052": 1.0229004621505737, "2003": 0.09317722171545029, "2005": 0.43812891840934753, "2007": 0.12470348179340363, "2008": 0.037378571927547455, "2029": 0.29619070887565613, "210... | 9142761 | Plasmodium falciparum surface protein 25 (Pfs25) is a candidate for transmission-blocking vaccines (TBVs). Anti-Pfs25 antibodies block the development of oocysts in membrane-feeding assays and we have shown the activity correlates with antibody titer. In this study, we purified Pfs25-specific IgGs to convert antibody t... | The IC(50) of anti-Pfs25 antibody in membrane-feeding assay varies among species. |
{"1003": 0.21530038118362427, "1011": 0.175953671336174, "1016": 0.10993985831737518, "1020": 0.010684899985790253, "1060": 0.5920094847679138, "1997": 0.03266380727291107, "1998": 0.1401015669107437, "2008": 0.11865071207284927, "2013": 0.2763880789279938, "2028": 0.10906458646059036, "2029": 0.22157983481884003, "203... | 9154703 | Expression from both alleles is generally observed in analyses of diploid cell populations, but studies addressing allelic expression patterns genome-wide in single cells are lacking. Here, we present global analyses of allelic expression across individual cells of mouse preimplantation embryos of mixed background (CAS... | Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells |
{"1011": 0.06154331564903259, "1016": 0.4734157919883728, "1018": 0.2447827309370041, "1020": 0.010684899985790253, "1043": 0.36697331070899963, "1048": 0.10026945173740387, "1050": 0.46055975556373596, "1052": 0.347847044467926, "1999": 0.1905880719423294, "2006": 0.052318159490823746, "2008": 0.07159364968538284, "20... | 9159125 | Macrophages produce a large amount of PGE(2) during inflammation. This lipid mediator modulates various immune responses. PGE(2) acts on macrophages and inhibits production of cytokines such as TNF-alpha and IL-12. Membrane-bound glutathione-dependent PGE(2) synthase (mPGES) has been shown to be a terminal enzyme of th... | Lipopolysaccharide-dependent prostaglandin E(2) production is regulated by the glutathione-dependent prostaglandin E(2) synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. |
{"1011": 0.29109421372413635, "1015": 0.175953671336174, "1039": 0.6911921501159668, "1040": 0.2852376699447632, "1041": 0.2105647772550583, "2007": 0.15777134895324707, "2008": 0.1913948506116867, "2011": 0.11778303235769272, "2015": 0.13157635927200317, "2029": 0.19782574474811554, "2039": 0.18654440343379974, "2043"... | 9159495 | Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated the network of genes that controls miRNA transcription and processing ... | A microRNA feedback loop regulates global microRNA abundance during aging. |
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