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{"1011": 0.42735910415649414, "1021": 1.09404456615448, "1038": 0.8383291959762573, "1045": 0.22704219818115234, "1048": 0.5685047507286072, "1056": 0.9240728616714478, "2007": 0.08154398202896118, "2011": 0.33675122261047363, "2029": 0.28670501708984375, "2043": 0.05046287178993225, "2076": 0.5027855634689331, "2077":... | 9160947 | Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor (IL-7R) belonging to the hematopoietin receptor superfamily. We have further addressed the role of IL-7 and its receptor during B and T cell development by generat... | Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice |
{"1019": 0.6038249135017395, "1037": 0.09584271162748337, "1052": 0.03831886500120163, "1054": 0.0029254043474793434, "1998": 0.0317181795835495, "2000": 0.02316705882549286, "2005": 0.058784693479537964, "2021": 0.05046287178993225, "2029": 0.1734936386346817, "2045": 0.15526613593101501, "2048": 0.3588210940361023, "... | 9161988 | The development of a safe and effective HIV vaccine is perhaps the most important and challenging goal remaining in HIV-AIDS research. Recent progress using a poxvirus vector prime and envelope protein boost strategy demonstrated a modest but statistically significant level of efficacy and established the concept that ... | Immune Activation with HIV Vaccines |
{"1011": 0.35128939151763916, "1021": 0.469759464263916, "1040": 0.7683706283569336, "1042": 0.36900100111961365, "1998": 0.09406650811433792, "1999": 0.24554696679115295, "2004": 0.42735910415649414, "2007": 0.3325583338737488, "2011": 0.4132472574710846, "2015": 0.15526613593101501, "2029": 0.3526630103588104, "2039"... | 9164724 | OBJECTIVE Dystrophins, utrophins, and their associated proteins are involved in structural and signaling roles in nonmuscle tissues; however, description of these proteins in neutrophils remained unexplored. Therefore we characterize the pattern expression, and the cellular distribution of dystrophin and utrophin gene ... | Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils. |
{"1003": 0.029824240133166313, "1014": 0.02412080205976963, "1019": 0.3622259199619293, "1023": 0.21372433006763458, "1052": 0.21293537318706512, "1997": 0.052318159490823746, "1999": 0.37304413318634033, "2001": 0.0038986403960734606, "2004": 0.00875066313892603, "2007": 0.04674193635582924, "2040": 0.5220900774002075... | 9167230 | BACKGROUND The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown. We aimed to estimate the incidence of admissions and deaths for such infections in children younger than 5 years in 2010. METHODS We estimated the in... | Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis |
{"1011": 0.18573370575904846, "1015": 0.0058422754518687725, "1043": 0.6118015646934509, "1050": 0.3519764244556427, "1052": 0.9680526852607727, "1997": 0.11081436276435852, "1999": 0.08961215615272522, "2000": 0.09761575609445572, "2004": 0.06886265426874161, "2005": 0.2501201331615448, "2008": 0.20818853378295898, "2... | 9169645 | The ability of p53 to induce apoptosis requires its sequence-specific DNA binding activity; however, the transactivation-deficient p53(Gln22-Ser23) can still induce apoptosis. Previously, we have shown that the region between residues 23 and 97 in p53 is necessary for such activity. In an effort to more precisely map a... | Identification of a novel p53 functional domain that is necessary for mediating apoptosis. |
{"1014": 0.4425300657749176, "1056": 0.6989894509315491, "1998": 0.2145126610994339, "2001": 0.16276304423809052, "2004": 0.037378571927547455, "2007": 0.06703783571720123, "2043": 0.1930064558982849, "2053": 0.1221139207482338, "2076": 0.16442140936851501, "2077": 0.0354953333735466, "2086": 0.26446542143821716, "2090... | 9171913 | In this prospective study, the relationship between blood lipids and breast cancer risk was examined. Between 1977 and 1983, 31,209 Norwegian women, 20 to 54 years of age, attended a health screening carried out by the Norwegian National Health Screening Services. The screening consisted of a questionnaire, anthropomet... | Risk of breast cancer in relation to blood lipids: a prospective study of 31,209 Norwegian women |
{"1038": 0.34370049834251404, "1040": 0.2247048318386078, "1048": 0.6654226183891296, "1999": 0.37304413318634033, "2029": 0.23556606471538544, "2034": 0.00875066313892603, "2039": 0.2852376699447632, "2063": 0.03360854089260101, "2076": 0.00875066313892603, "2091": 0.1946154683828354, "2106": 0.08513788133859634, "213... | 9178310 | Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in vitro. First, we showed that autophagosome formatio... | Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice |
{"1011": 0.28082266449928284, "1016": 0.2637155055999756, "1020": 0.14433705806732178, "1038": 0.3560888469219208, "1039": 0.17020416259765625, "1041": 0.2105647772550583, "1058": 0.5069117546081543, "1999": 0.037378571927547455, "2004": 0.12728634476661682, "2005": 0.009718249551951885, "2011": 0.42735910415649414, "2... | 9185195 | AIMS The vascular endothelial growth factor (VEGF) stimulates angiogenesis by induction of vessel permeability, proliferation, and migration of endothelial cells, an important process in ischaemic diseases. ADP-ribosylation factor (ARF) nucleotide-binding site opener (ARNO) (cytohesin-2) is a guanine exchange factor im... | ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression. |
{"1011": 0.16607704758644104, "1037": 0.9583619832992554, "1044": 0.18329764902591705, "1050": 0.6400018334388733, "1156": 0.8869584798812866, "1157": 0.16607704758644104, "1999": 0.19381128251552582, "2004": 0.2089812457561493, "2011": 0.40806588530540466, "2012": 0.28670501708984375, "2013": 0.3191637098789215, "2029... | 9194077 | Pathogenesis of Alzheimer’s disease (AD), which is characterised by accumulation of extracellular deposits of β-amyloid peptide (Aβ) in the brain, has recently been linked to vascular disorders such as ischemia and stroke. Aβ is constantly produced in the brain from amyloid precursor protein (APP) through its cleavage ... | Effects of Hypoxia and Oxidative Stress on Expression of Neprilysin in Human Neuroblastoma Cells and Rat Cortical Neurones and Astrocytes |
{"1014": 0.4824984669685364, "1052": 0.3304552733898163, "1053": 0.15610189735889435, "1055": 0.5773153901100159, "1997": 0.2667117714881897, "2006": 0.011650617234408855, "2007": 0.011650617234408855, "2011": 0.0797421783208847, "2012": 0.3325583338737488, "2020": 0.06886265426874161, "2049": 0.03266380727291107, "206... | 9196472 | BACKGROUND Variability of gene expression in human may link gene sequence variability and phenotypes; however, non-genetic variations, alone or in combination with genetics, may also influence expression traits and have a critical role in physiological and disease processes. METHODOLOGY/PRINCIPAL FINDINGS To get better... | Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility |
{"1011": 0.10291612148284912, "1039": 1.12432062625885, "1041": 0.07793712615966797, "1043": 0.1946154683828354, "1999": 0.06429435312747955, "2002": 0.8625272512435913, "2005": 0.10731173306703568, "2011": 0.1946154683828354, "2029": 0.2409527748823166, "2038": 0.09406650811433792, "2050": 0.03831886500120163, "2053":... | 9197092 | Dietary polyphenols have been associated with reduced risk of chronic diseases, but the precise molecular mechanisms of protection remain unclear. This work was aimed at studying the effect of (-)-epicatechin (EC) and chlorogenic acid (CGA) on the regulation of apoptotic and survival/proliferation pathways in a human h... | Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell line. |
{"1011": 0.04860413447022438, "1019": 0.24248650670051575, "1039": 0.045809537172317505, "1042": 0.43244171142578125, "1050": 0.23710809648036957, "1059": 0.7601850032806396, "2003": 0.33115679025650024, "2005": 0.055094651877880096, "2011": 0.23015019297599792, "2029": 0.06977381557226181, "2050": 0.4349733293056488, ... | 9197786 | Nerve growth factor (NGF) is a potent survival and axon growth factor for neuronal populations in the peripheral nervous system. Although the mechanisms by which target-derived NGF influences survival of innervating neurons have been extensively investigated, its regulation of axonal growth and target innervation are j... | Wnt5a mediates nerve growth factor-dependent axonal branching and growth in developing sympathetic neurons. |
{"1011": 0.10555581003427505, "1015": 0.19782574474811554, "1022": 0.23324857652187347, "1043": 0.05139094591140747, "1055": 0.6538092494010925, "2003": 0.1946154683828354, "2008": 0.1685553640127182, "2011": 0.43623676896095276, "2025": 0.09406650811433792, "2029": 0.319873183965683, "2073": 0.02316705882549286, "2076... | 9199796 | Among lower eukaryotes, glucose repression is a conserved, widely spread mechanism regulating carbon catabolism. The yeast Snf1 kinase, the Mig1 DNA-binding repressor and the Mig1-interacting co-repressor complex Cyc8(Ssn6)-Tup1 are central components of this pathway. Previous experiments suggested that cytoplasmic tra... | The Snf1 kinase controls glucose repression in yeast by modulating interactions between the Mig1 repressor and the Cyc8-Tup1 co-repressor. |
{"1011": 0.17431432008743286, "1015": 0.04860413447022438, "1051": 0.8004589080810547, "1055": 0.13925230503082275, "2007": 0.0058422754518687725, "2011": 0.11256109178066254, "2012": 0.36900100111961365, "2013": 0.2247048318386078, "2020": 0.02412080205976963, "2029": 0.06429435312747955, "2046": 0.27934664487838745, ... | 9211173 | BACKGROUND Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS We sequenced the whole transcriptomes of 18 ovarian clear-cell carcinomas and 1 ovarian clear-cell carcinoma cell line and found somatic mutat... | ARID1A mutations in endometriosis-associated ovarian carcinomas. |
{"1011": 0.41840189695358276, "1048": 0.29981520771980286, "1056": 0.7987030148506165, "1998": 0.12556517124176025, "1999": 0.029824240133166313, "2007": 0.3519764244556427, "2011": 0.151916041970253, "2015": 0.9162907600402832, "2021": 0.06886265426874161, "2025": 0.2763880789279938, "2029": 0.23710809648036957, "2036... | 9217800 | The fatal adult motor neuron disease amyotrophic lateral sclerosis (ALS) shares some clinical and pathological overlap with frontotemporal dementia (FTD), an early-onset neurodegenerative disorder. The RNA/DNA-binding proteins fused in sarcoma (FUS; also known as TLS) and TAR DNA binding protein-43 (TDP-43) have recent... | The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span. |
{"1011": 0.03831886500120163, "1017": 0.4132472574710846, "1050": 0.2990913391113281, "1052": 0.06886265426874161, "1996": 0.09495500475168228, "2003": 0.21687394380569458, "2007": 0.02792670577764511, "2008": 0.17431432008743286, "2011": 0.19622190296649933, "2015": 0.5278670787811279, "2024": 0.4673144817352295, "202... | 9225850 | Neutrophils are peripheral blood leukocytes that represent the first line of immune cell defense against bacterial and fungal infections but are also crucial players in the generation of the inflammatory response. Many neutrophil cell surface receptors regulate important cellular processes via activation of agonist-act... | Non-canonical PI3K-Cdc42-Pak-Mek-Erk Signaling Promotes Immune-Complex-Induced Apoptosis in Human Neutrophils |
{"1015": 0.38174858689308167, "1996": 0.16524957120418549, "1999": 0.7755908370018005, "2011": 0.3381449282169342, "2029": 0.1751343309879303, "2063": 0.500420093536377, "2066": 0.25239890813827515, "2076": 0.030771657824516296, "2078": 0.36426326632499695, "2083": 0.34370049834251404, "2099": 0.8091925978660583, "2109... | 9226649 | Chronic inflammation is a known risk factor for tumorigenesis, yet the precise mechanism of this association is currently unknown. The inflammasome, a multiprotein complex formed by NOD-like receptor (NLR) family members, has recently been shown to orchestrate multiple innate and adaptive immune responses, yet its pote... | Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. |
{"1011": 0.07341018319129944, "1015": 0.1510767638683319, "1017": 0.11951763927936554, "1039": 0.42735910415649414, "1041": 0.0058422754518687725, "1042": 0.6202403903007507, "1048": 0.6054253578186035, "1999": 0.037378571927547455, "2005": 0.04860413447022438, "2007": 0.2800849378108978, "2011": 0.4330752193927765, "2... | 9239963 | Excessive exposure to estradiol represents the main risk factor for endometrial cancer. The abnormally high estradiol levels in the endometrium of women with endometrial cancer are most likely due to overproduction by the tumour itself. Endometrial cancer cells express the genes encoding the steroidogenic enzymes invol... | The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors. |
{"1039": 0.34023189544677734, "1043": 0.1994270235300064, "1051": 0.39367714524269104, "2002": 0.13414156436920166, "2005": 0.18004031479358673, "2008": 0.15526613593101501, "2020": 0.14264501631259918, "2022": 0.012615402229130268, "2024": 0.026025565341114998, "2025": 0.32129061222076416, "2028": 0.19220098853111267,... | 9244474 | Diet is known to play a major role in the symptoms of the inflammatory bowel disease, Crohn's disease (CD). Although no single diet is appropriate to all individuals, most CD patients are aware of foods that provide adverse or beneficial effects. This study seeks to categorise foods in relation to their effects on symp... | Dietary factors in chronic inflammation: food tolerances and intolerances of a New Zealand Caucasian Crohn's disease population. |
{"1014": 0.3963087201118469, "1022": 0.013579257763922215, "1023": 0.2711893916130066, "1026": 0.04113444685935974, "1048": 0.12986256182193756, "1052": 0.2852376699447632, "1054": 0.5816917419433594, "1061": 0.2990913391113281, "1999": 0.029824240133166313, "2002": 0.00875066313892603, "2007": 0.27564704418182373, "20... | 9254550 | BACKGROUND & OBJECTIVES Anaemia is commonly observed in children with malaria, but reports on leucocyte and platelet count abnormalities associated with malaria are inconsistent. This study examined the effect of age, gender, parasite density and temperature on haematological parameters in children with acute uncomplic... | Age as a risk factor for thrombocytopenia and anaemia in children treated for acute uncomplicated falciparum malaria. |
{"1038": 0.4158279001712799, "1048": 0.5729197263717651, "1056": 0.3106105625629425, "1999": 0.3622259199619293, "2007": 0.02316705882549286, "2008": 0.10818854719400406, "2011": 0.5104349255561829, "2029": 0.3601844012737274, "2037": 0.01934296265244484, "2039": 0.2317005842924118, "2073": 0.24859806895256042, "2076":... | 9257019 | Evidence has been obtained that catecholamines and their metabolites are present in single lymphocytes and extracts of T- and B-cell clones by use of capillary electrophoresis with electrochemical detection. Pharmacological inhibition of tyrosine hydroxylase reduces observed catecholamine levels, suggesting catecholami... | Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop. |
{"1011": 0.012615402229130268, "1997": 0.04394211992621422, "1999": 0.1401015669107437, "2004": 0.012615402229130268, "2005": 0.27044451236724854, "2007": 0.18167030811309814, "2011": 0.1221139207482338, "2019": 0.026025565341114998, "2024": 0.11081436276435852, "2029": 0.08244366943836212, "2046": 0.32129061222076416,... | 9272598 | Prions cause transmissible spongiform encephalopathies for which no treatment exists. Prions consist of PrPSc, a misfolded and aggregated form of the cellular prion protein (PrPC). We explore the antiprion properties of luminescent conjugated polythiophenes (LCPs) that bind and stabilize ordered protein aggregates. By ... | Structure-based drug design identifies polythiophenes as antiprion compounds |
{"1052": 0.20501139760017395, "1998": 0.28963330388069153, "2006": 0.7408206462860107, "2007": 0.16607704758644104, "2015": 0.09850110858678818, "2031": 0.040196798741817474, "2037": 0.18978065252304077, "2039": 0.503966212272644, "2060": 0.4974553883075714, "2062": 0.4537591338157654, "2064": 0.16524957120418549, "208... | 9274291 | PURPOSE To compare expectations for cancer survivorship care between patients and their physicians and between primary care providers (PCPs) and oncologists. METHODS Survivors and their physicians were surveyed to evaluate for expectations regarding physician participation in primary cancer follow-up, screening for oth... | Comparisons of patient and physician expectations for cancer survivorship care. |
{"1011": 0.19782574474811554, "1015": 0.6897233724594116, "1045": 0.9673105478286743, "1048": 0.42990362644195557, "1049": 1.0478670597076416, "1996": 0.0354953333735466, "1998": 0.25995752215385437, "2005": 0.05139094591140747, "2011": 0.32129061222076416, "2015": 0.2830325961112976, "2028": 0.37707099318504333, "2029... | 9278263 | The cell surface display of peptides by MHC class I molecules to lymphocytes provides the host with an important surveillance mechanism to protect against invading pathogens. However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent t... | MHC class I antigen presentation: learning from viral evasion strategies |
{"1011": 0.36426326632499695, "1039": 0.4624064862728119, "1042": 0.5272908806800842, "1048": 0.26446542143821716, "1049": 0.21530038118362427, "1056": 1.0506030321121216, "1057": 0.28450319170951843, "1999": 0.2089812457561493, "2008": 0.034552380442619324, "2011": 0.5313173532485962, "2013": 0.010684899985790253, "20... | 9283422 | T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activation cluster (cSMAC). We showed that the cSMAC formed by fusion of microclusters contained more CD45 than microclusters and is a site enriched i... | T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. |
{"1014": 0.255429208278656, "1026": 0.11951763927936554, "1040": 0.4537591338157654, "1050": 0.40481385588645935, "1052": 0.4196864068508148, "1054": 0.3070250153541565, "1059": 0.26446542143821716, "1081": 0.7647408246994019, "1609": 0.49864232540130615, "2001": 0.02792670577764511, "2042": 0.011650617234408855, "2044... | 9285396 | BACKGROUND Although the red cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge the prognostic value of RDW in gastric carcinoma has not been studied, so far. OBJECTIVE We aimed to investigate the role of red cell distribution width (RDW) in ... | The role of red cell distribution width in the prognosis of patients with gastric cancer. |
{"1011": 0.14686977863311768, "1016": 0.07159364968538284, "1019": 0.3519764244556427, "1044": 0.5186077356338501, "1059": 0.8143964409828186, "1998": 0.3163207769393921, "1999": 0.22001366317272186, "2007": 0.16276304423809052, "2011": 0.19782574474811554, "2013": 0.06337817758321762, "2020": 0.0797421783208847, "2025... | 9288638 | OBJECTIVE The aim of this study was to investigate whether diabetes and hypertension cause additive effects in the responses to various vasoconstrictor and vasodilator agents, in isolated perfused kidneys obtained from streptozotocin (STZ)-diabetic Wistar-Kyoto (WKY) rats and from diabetic spontaneously hypertensive ra... | Vascular responsiveness in isolated perfused kidneys of diabetic hypertensive rats. |
{"1006": 0.3870677351951599, "1011": 0.24401791393756866, "1013": 0.33325836062431335, "1015": 0.2749055027961731, "1016": 0.34300774335861206, "1018": 0.9092346429824829, "1019": 0.26146242022514343, "1022": 0.27934664487838745, "1043": 0.7426811456680298, "1044": 0.011650617234408855, "1049": 0.34023189544677734, "10... | 9291596 | Following introduction of DNA interstrand cross-links (ICLs), mammalian cells display chromosome breakage or cell cycle delay with a 4N DNA content. To further understand the nature of the delay, previously described as a G(2)/M arrest, we developed a protocol to generate ICLs during specific intervals of the cell cycl... | DNA replication is required To elicit cellular responses to psoralen-induced DNA interstrand cross-links. |
{"1997": 0.176772341132164, "1998": 0.043007105588912964, "2012": 0.1751343309879303, "2029": 0.009718249551951885, "2042": 0.09406650811433792, "2048": 0.38041436672210693, "2057": 0.022212404757738113, "2058": 0.5778634548187256, "2064": 0.13670019805431366, "2070": 0.20818853378295898, "2073": 0.0354953333735466, "2... | 9291668 | The process of aging results in a host of changes at the cellular and molecular levels, which include senescence, telomere shortening, and changes in gene expression. Epigenetic patterns also change over the lifespan, suggesting that epigenetic changes may constitute an important component of the aging process. The epi... | DNA methylation and healthy human aging |
{"1011": 0.04394211992621422, "1017": 0.0038986403960734606, "1018": 0.472198486328125, "1038": 0.500420093536377, "1041": 0.9650808572769165, "1051": 0.40351006388664246, "2006": 0.07884006202220917, "2008": 0.07250232994556427, "2011": 0.3134697377681732, "2012": 0.2830325961112976, "2029": 0.23479416966438293, "2058... | 9301606 | Parathyroid hormone (PTH), a major regulator of bone metabolism, activates the PTHR1 receptor on the osteoblast plasma membrane to initiate signaling and induce transcription of primary response genes. Subsequently, primary genes with transcriptional activity regulate expression of downstream PTH targets. We have ident... | Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts. |
{"1011": 0.22392450273036957, "1039": 0.4002431631088257, "1041": 0.20421554148197174, "1047": 0.33115679025650024, "2007": 0.27564704418182373, "2011": 0.35403475165367126, "2012": 0.13071982562541962, "2013": 0.06520967930555344, "2015": 0.3191637098789215, "2024": 0.010684899985790253, "2029": 0.1913948506116867, "2... | 9304312 | Synaptic transmission depends on clathrin-mediated recycling of synaptic vesicles (SVs). How select SV proteins are targeted for internalization has remained elusive. Stonins are evolutionarily conserved adaptors dedicated to endocytic sorting of the SV protein synaptotagmin. Our data identify the molecular determinant... | Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2 |
{"1014": 0.5506471395492554, "1054": 0.7342816591262817, "1061": 0.5573811531066895, "1998": 0.19541899859905243, "1999": 0.1011524572968483, "2022": 0.0174254160374403, "2060": 0.2160874605178833, "2062": 0.06977381557226181, "2064": 0.24859806895256042, "2084": 0.4849066734313965, "2090": 0.23247487843036652, "2098":... | 9306247 | BACKGROUND Analysis of fetal DNA in maternal plasma has recently been introduced as a new method for noninvasive prenatal diagnosis, particularly for the analysis of fetal genetic traits, which are absent from the maternal genome, e.g., RHD or Y-chromosome-specific sequences. To date, the analysis of other fetal geneti... | Size separation of circulatory DNA in maternal plasma permits ready detection of fetal DNA polymorphisms. |
{"1003": 0.07341018319129944, "1014": 0.3897167444229126, "1017": 0.083342544734478, "1019": 0.0752234235405922, "1026": 0.11951763927936554, "1044": 0.1332872211933136, "1052": 0.28743788599967957, "1056": 0.36900100111961365, "1081": 1.0326838493347168, "1997": 0.0009760859538801014, "1999": 0.5415972471237183, "2005... | 9310407 | INTRODUCTION Isotonic crystalloids play a central role in perioperative fluid management. Isooncotic preparations of colloids (for example, human albumin or hydroxyethyl starch) remain nearly completely intravascular when infused to compensate for acute blood losses. Recent data were interpreted to indicate a comparabl... | The intravascular volume effect of Ringer's lactate is below 20%: a prospective study in humans |
{"1011": 0.06612417846918106, "1041": 0.6744182109832764, "1042": 1.1923824548721313, "1043": 0.39367714524269104, "1155": 0.052318159490823746, "1157": 0.01934296265244484, "2002": 0.5963221788406372, "2003": 0.18004031479358673, "2011": 0.20739519596099854, "2012": 0.565735399723053, "2029": 0.1677299439907074, "2076... | 9315213 | BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts as a key downstream target of both peroxisome proliferator-activated receptor α and γ, the agonists of which have been used for lipid lowering and insulin sensi... | Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice |
{"1011": 0.08513788133859634, "1014": 0.040196798741817474, "1048": 0.255429208278656, "1052": 0.27712854743003845, "1058": 0.2696990668773651, "1060": 0.4318077862262726, "2003": 0.5903874635696411, "2005": 0.14686977863311768, "2050": 0.3982778787612915, "2054": 0.03925827145576477, "2078": 0.5472630262374878, "2109"... | 9317504 | DESCRIPTION VARNA is a tool for the automated drawing, visualization and annotation of the secondary structure of RNA, designed as a companion software for web servers and databases. FEATURES VARNA implements four drawing algorithms, supports input/output using the classic formats dbn, ct, bpseq and RNAML and exports t... | VARNA: Interactive drawing and editing of the RNA secondary structure |
{"1011": 0.29400965571403503, "1015": 0.1808556467294693, "1020": 0.4818955361843109, "1022": 0.3949938118457794, "1039": 0.8083226680755615, "1045": 0.28155985474586487, "2007": 0.3012613356113434, "2011": 0.13499516248703003, "2012": 0.6160298585891724, "2015": 0.3743882179260254, "2029": 0.27712854743003845, "2058":... | 9334631 | OBJECTIVE C-Reactive protein (CRP), a cardiovascular risk marker, could also participate in atherosclerosis. Atherosclerotic plaques express CRP and interleukin (IL)-10, a major antiinflammatory cytokine. IL-10 deficiency results in increased lesion formation, whereas IL-10 delivery attenuates lesions. We tested the ef... | C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production. |
{"1041": 0.13925230503082275, "1052": 0.6970458030700684, "1060": 0.5963221788406372, "1155": 0.5860490798950195, "1158": 0.28155985474586487, "1159": 1.072225570678711, "1999": 0.21214580535888672, "2005": 0.17020416259765625, "2008": 0.04767346754670143, "2011": 0.3883931338787079, "2029": 0.3615458607673645, "2034":... | 9379687 | DNA polymerase ε (Pol ε) is involved in DNA replication, repair, and cell-cycle checkpoint control in eukaryotic cells. Although the roles of replicative Pol α and Pol δ in chromosomal DNA replication are relatively well understood and well documented, the precise role of Pol ε in chromosomal DNA replication is not wel... | The DNA polymerase activity of Pol ε holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts |
{"1011": 0.46117570996284485, "1035": 0.09228714555501938, "1040": 0.39696553349494934, "1042": 0.018384648486971855, "1051": 0.5174443125724792, "1055": 0.6553317308425903, "1996": 0.12814582884311676, "2003": 0.09317722171545029, "2005": 0.11256109178066254, "2008": 0.13670019805431366, "2011": 0.31132611632347107, "... | 9393969 | Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nexus in these responses, but despite its importance little is known about how it regulates its targ... | DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity |
{"1015": 0.2247048318386078, "1016": 0.0606246218085289, "1039": 0.5528968572616577, "1051": 0.5057345628738403, "1052": 0.09317722171545029, "1054": 0.7656494975090027, "2004": 0.3850763738155365, "2013": 0.03266380727291107, "2015": 0.12986256182193756, "2028": 0.06337817758321762, "2029": 0.026025565341114998, "2057... | 9394119 | IMPORTANCE Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE To identify mutation-specific cancer risks for carriers of BRCA1/2. DESIGN, SETTING, AND PARTICIPANTS Observational study of women who were ascertained between 1937 and 2011 (me... | Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. |
{"1009": 0.6420594453811646, "1011": 0.07068414986133575, "1015": 0.29109421372413635, "1049": 0.1229778528213501, "1051": 0.3070250153541565, "1999": 0.2493593990802765, "2003": 0.05970508232712746, "2013": 0.08782484382390976, "2015": 0.8658194541931152, "2024": 0.29109421372413635, "2028": 0.10555581003427505, "2033... | 9412420 | Mesenchymal stem cells (MSCs) commonly defined by in vitro functions have entered clinical application despite little definition of their function in residence. Here, we report genetic pulse-chase experiments that define osteoblastic cells as short-lived and nonreplicative, requiring replenishment from bone-marrow-deri... | Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. |
{"1040": 0.3409265875816345, "1045": 0.8161250352859497, "2004": 0.129004567861557, "2005": 0.10818854719400406, "2007": 0.10467668622732162, "2011": 0.29109421372413635, "2015": 0.39367714524269104, "2029": 0.09317722171545029, "2075": 0.07341018319129944, "2079": 0.09495500475168228, "2091": 0.42161011695861816, "210... | 9420732 | Cadherins and the immunoglobulin (Ig) proteins give rise to a multitude of surface receptors, which function as diverse cell adhesion molecules (CAMs) or signal-transducing receptors. These functions are often interdependent, and rely on a high degree of specificity in homophilic binding as well as heterophilic interac... | Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes. |
{"1996": 0.15693697333335876, "2008": 0.021256839856505394, "2013": 0.3526630103588104, "2029": 0.17431432008743286, "2031": 0.31560876965522766, "2036": 0.14433705806732178, "2037": 0.31845372915267944, "2038": 0.1808556467294693, "2048": 0.5795059204101562, "2065": 0.7500885725021362, "2072": 0.32553088665008545, "20... | 9433958 | Although susceptibility of neurons in the brain to microbial infection is a major determinant of clinical outcome, little is known about the molecular factors governing this vulnerability. Here we show that two types of neurons from distinct brain regions showed differential permissivity to replication of several posit... | Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses |
{"1014": 0.6872705817222595, "1015": 0.11343330889940262, "1016": 0.3262358605861664, "1017": 0.33115679025650024, "1018": 0.2954642176628113, "1019": 0.06246116757392883, "1026": 0.29473719000816345, "1039": 0.08961215615272522, "1049": 0.026025565341114998, "1051": 0.2822965085506439, "1052": 0.6139179468154907, "160... | 9440748 | BACKGROUND The major sites of obstruction in chronic obstructive pulmonary disease (COPD) are small airways (<2 mm in diameter). We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD. METHODS We used multidetector computed tomography (CT) to compa... | Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. |
{"1011": 0.3423145115375519, "1015": 0.0009760859538801014, "1016": 0.08782484382390976, "1044": 0.7764897346496582, "1062": 1.436757206916809, "1996": 0.040196798741817474, "1997": 0.026976587250828743, "1999": 0.06520967930555344, "2002": 0.1873544454574585, "2004": 0.3743882179260254, "2007": 0.034552380442619324, "... | 9451052 | Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes with H2A.Z in an ATP-dependent manner. Here, we show that promoter-proximal nucleosomes are highly heterogeneous f... | Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome |
{"1997": 0.01934296265244484, "1998": 0.0317181795835495, "2029": 0.08244366943836212, "2037": 0.04674193635582924, "2043": 0.08961215615272522, "2051": 0.38041436672210693, "2058": 0.012615402229130268, "2076": 0.6877616047859192, "2079": 0.14179791510105133, "2083": 0.06612417846918106, "2089": 0.011650617234408855, ... | 9451684 | Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit simil... | Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. |
{"1022": 0.037378571927547455, "1047": 0.15693697333335876, "1048": 0.11256109178066254, "1049": 0.058784693479537964, "2000": 0.04674193635582924, "2002": 0.10291612148284912, "2003": 0.15023678541183472, "2004": 0.15943801403045654, "2005": 0.347847044467926, "2011": 0.11430477350950241, "2012": 0.9194108247756958, "... | 9460704 | Differentiation therapy has emerged as a powerful way to target specific hematologic malignancies. One of the best examples is the use of all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL), which has significantly improved the outcome for patients with this specific form of acute myeloid leukemia (AML... | Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia. |
{"1014": 0.04394211992621422, "1015": 0.500420093536377, "1017": 0.2741633653640747, "1048": 0.10906458646059036, "1049": 0.53589928150177, "1998": 0.17759032547473907, "2007": 0.1685553640127182, "2009": 0.6048921346664429, "2015": 0.19622190296649933, "2026": 0.6086184978485107, "2028": 0.16690383851528168, "2029": 0... | 9478135 | Point mutations of the transcription factor AML1 are associated with leukemogenesis in acute myeloblastic leukemia (AML). Internal tandem duplications (ITDs) in the juxtamembrane domain and mutations in the second tyrosine kinase domain of the Fms-like tyrosine kinase 3 (FLT3) gene represent the most frequent genetic a... | Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype |
{"1052": 1.2273306846618652, "1999": 0.0029254043474793434, "2003": 0.2969166338443756, "2005": 0.045809537172317505, "2008": 0.20580662786960602, "2011": 0.12384103983640671, "2029": 0.31132611632347107, "2060": 0.11604541540145874, "2076": 0.2478361576795578, "2079": 0.24631060659885406, "2109": 0.1384023278951645, "... | 9483851 | p53 is a crucial tumour suppressor that responds to diverse stress signals by orchestrating specific cellular responses, including transient cell cycle arrest, cellular senescence and apoptosis, which are all processes associated with tumour suppression. However, recent studies have challenged the relative importance o... | Unravelling mechanisms of p53-mediated tumour suppression |
{"1011": 0.0009760859538801014, "1020": 0.48008447885513306, "1041": 0.5278670787811279, "1043": 0.9987343549728394, "1051": 0.21765978634357452, "1052": 0.5668440461158752, "2005": 0.38574060797691345, "2020": 0.022212404757738113, "2024": 0.10026945173740387, "2034": 0.055094651877880096, "2066": 0.4891071021556854, ... | 9486930 | PURPOSE Glioblastomas are notorious for resistance to therapy, which has been attributed to DNA-repair proficiency, a multitude of deregulated molecular pathways, and, more recently, to the particular biologic behavior of tumor stem-like cells. Here, we aimed to identify molecular profiles specific for treatment resist... | Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma. |
{"1011": 0.22859740257263184, "1017": 0.14602625370025635, "1021": 0.4920966327190399, "1041": 0.841701865196228, "1056": 0.7863243818283081, "1062": 0.15610189735889435, "2003": 0.2983669638633728, "2007": 0.2105647772550583, "2012": 0.056018441915512085, "2029": 0.06429435312747955, "2034": 0.47584590315818787, "2048... | 9498458 | UNLABELLED Rociletinib is a third-generation EGFR inhibitor active in lung cancers with T790M, the gatekeeper mutation underlying most first-generation EGFR drug resistance. We biopsied patients at rociletinib progression to explore resistance mechanisms. Among 12 patients with T790M-positive cancers at rociletinib ini... | Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor. |
{"1011": 0.09850110858678818, "1015": 0.35128939151763916, "1017": 0.38374659419059753, "1056": 0.906871497631073, "1060": 0.659380316734314, "1996": 0.07793712615966797, "2007": 0.053244512528181076, "2011": 0.3346569836139679, "2015": 0.6327666640281677, "2028": 0.026976587250828743, "2029": 0.22157983481884003, "203... | 9500590 | Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, are generated in the thymus (tTreg) and extrathymically (peripheral, pTreg), and their deficiency results in fatal autoimmunity. Here, we demonstrate that a Foxp3 enhancer, conserved noncodin... | Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict |
{"1021": 0.3723714053630829, "1039": 0.5324648022651672, "1041": 0.803087055683136, "1056": 0.8433839678764343, "1062": 0.08064348995685577, "2005": 0.15777134895324707, "2008": 0.029824240133166313, "2011": 0.20102575421333313, "2013": 0.09850110858678818, "2015": 0.4974553883075714, "2029": 0.2231435477733612, "2034"... | 9505402 | Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) AZD9291. We first performed next-generation sequencing of cfDNA from seven subjects and detected an acquired... | Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M |
{"1011": 0.09584271162748337, "1015": 0.21765978634357452, "1017": 0.3601844012737274, "1041": 0.8349450826644897, "1048": 0.30558720231056213, "1057": 0.4914994537830353, "1059": 0.3141832649707794, "1062": 0.6064908504486084, "1996": 0.009718249551951885, "2004": 0.14179791510105133, "2006": 0.07159364968538284, "201... | 9505448 | Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcriptionally active molecule. The Notch1 receptor was proposed to be mono... | The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation |
{"1011": 0.3141832649707794, "1015": 0.0317181795835495, "1016": 0.05046287178993225, "1017": 0.11951763927936554, "1039": 0.6064908504486084, "1049": 0.036437395960092545, "1050": 0.00875066313892603, "1054": 0.9287132620811462, "1056": 0.13670019805431366, "2004": 0.22392450273036957, "2005": 0.02316705882549286, "20... | 9507605 | The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II–driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal c... | Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCKindependent mechanism |
{"1014": 0.38174858689308167, "1015": 0.176772341132164, "1020": 0.02412080205976963, "1039": 0.43434104323387146, "1045": 0.4673144817352295, "1052": 0.6410312056541443, "2011": 0.058784693479537964, "2033": 0.3077431619167328, "2039": 0.21214580535888672, "2048": 0.1619328260421753, "2050": 0.006812678650021553, "205... | 9513785 | We previously reported that maternal protein restriction in rodents influenced the rate of growth in early life and ultimately affected longevity. Low birth weight caused by maternal protein restriction followed by catch-up growth (recuperated animals) was associated with shortened lifespan whereas protein restriction ... | Maternal Protein Restriction Affects Postnatal Growth and the Expression of Key Proteins Involved in Lifespan Regulation in Mice |
{"2007": 0.37640097737312317, "2019": 0.26446542143821716, "2047": 0.2105647772550583, "2048": 0.03266380727291107, "2055": 0.08871890604496002, "2062": 0.2478361576795578, "2089": 0.08513788133859634, "2094": 0.37304413318634033, "2114": 0.02316705882549286, "2116": 0.21687394380569458, "2119": 0.05970508232712746, "2... | 9538708 | Recent studies report comparable psychosocial adaptation in children with or without a growth disorder. These findings may be due to a general lack of sensitive and specific techniques for analysing and comparing their respective qualities of life. In this study we present a new questionnaire for parents of short-statu... | ‘Short stature in children - a questionnaire for parents’: a new instrument for growth disorder-specific psychosocial adaptation in children |
{"1058": 0.11691460013389587, "1999": 0.034552380442619324, "2004": 0.2786078155040741, "2015": 0.32058215141296387, "2020": 0.02887592278420925, "2072": 0.9052929878234863, "2079": 0.12384103983640671, "2129": 0.10026945173740387, "2166": 0.08603433519601822, "2229": 0.4311734735965729, "2310": 0.47036975622177124, "2... | 9539248 | Mosquito-borne viruses cause significant levels of morbidity and mortality in humans and domesticated animals. Maintenance of mosquito-borne viruses in nature requires a biological transmission cycle that involves alternating virus replication in a susceptible vertebrate and mosquito host. Although the vertebrate infec... | Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes. |
{"1011": 0.055094651877880096, "1017": 0.21214580535888672, "1018": 0.0038986403960734606, "1023": 0.2749055027961731, "1039": 0.5925496220588684, "1041": 0.08244366943836212, "1044": 0.26146242022514343, "1048": 0.18329764902591705, "1999": 0.1229778528213501, "2007": 0.02792670577764511, "2008": 0.03831886500120163, ... | 9539753 | RNA interference (RNAi) is heritable in Caenorhabditis elegans; the progeny of C. elegans exposed to dsRNA inherit the ability to silence genes that were targeted by RNAi in the previous generation. Here we investigate the mechanism of RNAi inheritance in C. elegans. We show that exposure of animals to dsRNA results in... | Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans. |
{"1003": 0.025073638185858727, "1019": 0.13071982562541962, "1023": 0.22001366317272186, "1037": 0.034552380442619324, "1057": 0.030771657824516296, "1997": 0.1011524572968483, "2001": 0.058784693479537964, "2004": 0.0606246218085289, "2020": 0.2990913391113281, "2037": 0.04674193635582924, "2042": 0.07068414986133575,... | 9547722 | BACKGROUND Cancer survivors represent a growing population, heterogeneous in their need for medical care, psychosocial support, and practical assistance. To inform survivorship research and practice, this manuscript will describe the prevalent population of cancer survivors in terms of overall numbers and prevalence by... | Cancer survivors in the United States: prevalence across the survivorship trajectory and implications for care. |
{"1003": 0.22626367211341858, "1051": 0.8195732831954956, "1997": 0.015504186972975731, "1998": 0.10379679501056671, "1999": 0.02887592278420925, "2008": 0.06246116757392883, "2015": 0.4248080551624298, "2019": 0.8885661959648132, "2029": 0.27044451236724854, "2035": 0.1332872211933136, "2073": 0.151916041970253, "2080... | 9548440 | Trisomic and monosomic (aneuploid) embryos account for at least 10% of human pregnancies and, for women nearing the end of their reproductive lifespan, the incidence may exceed 50%. The errors that lead to aneuploidy almost always occur in the oocyte but, despite intensive investigation, the underlying molecular basis ... | Human aneuploidy: mechanisms and new insights into an age-old problem |
{"1011": 0.09228714555501938, "1040": 0.04767346754670143, "1052": 0.4311734735965729, "1996": 0.3374483287334442, "1999": 0.1710275560617447, "2011": 0.4330752193927765, "2012": 0.10467668622732162, "2021": 0.10026945173740387, "2025": 0.5151132941246033, "2029": 0.21135559678077698, "2031": 0.2409527748823166, "2038"... | 9550981 | The adult Drosophila hindgut was recently reported to contain active, tissue-replenishing stem cells, like those of the midgut, but located within an anterior ring so as to comprise a single giant crypt. In contrast to this view, we observed no active stem cells and little cell turnover in adult hindgut tissue based on... | The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage. |
{"1003": 0.040196798741817474, "1014": 0.4311734735965729, "1038": 0.5255602598190308, "1040": 1.1356772184371948, "1044": 0.21530038118362427, "1052": 0.46914875507354736, "1056": 0.10731173306703568, "1058": 1.1450434923171997, "1062": 0.890972912311554, "2007": 0.12384103983640671, "2029": 0.0606246218085289, "2044"... | 9555784 | INTRODUCTION Low vitamin D (VD) is associated with secondary hyperparathyroidism and both contribute to deleterious consequences (reduced bone mineral density (BMD), risk of fractures and falls). OBJECTIVE To study the VD status and biological correlates in a group of postmenopausal women. MATERIAL AND METHODS We studi... | Vitamin d deficiency in postmenopausal women - biological correlates. |
{"1011": 0.33675122261047363, "1017": 0.2763880789279938, "1020": 0.2447827309370041, "1039": 0.4818955361843109, "1044": 0.6624060273170471, "1059": 0.38574060797691345, "1156": 0.436867892742157, "1999": 0.021256839856505394, "2002": 0.6941232681274414, "2005": 0.1212492436170578, "2011": 0.35813871026039124, "2029":... | 9558539 | Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors. CD44v6 expression is low in primary tumors but d... | CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. |
{"1052": 0.6212902665138245, "2003": 0.09761575609445572, "2011": 0.3141832649707794, "2013": 0.39433568716049194, "2029": 0.1808556467294693, "2037": 0.056018441915512085, "2041": 0.3910386264324188, "2063": 0.2576959431171417, "2064": 0.06612417846918106, "2076": 0.17431432008743286, "2079": 0.07159364968538284, "208... | 9559146 | Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin. This response, termed cellular senescence, is controlled by the p53 and RB tumor suppressor proteins a... | Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors |
{"1017": 0.18978065252304077, "1041": 0.27564704418182373, "1042": 0.18004031479358673, "1998": 0.0606246218085289, "2000": 0.09672962874174118, "2005": 0.0354953333735466, "2054": 0.2622140049934387, "2057": 0.03360854089260101, "2064": 0.1221139207482338, "2079": 0.21922965347766876, "2084": 0.0038986403960734606, "2... | 9580772 | A fundamental goal in biology is to determine how cellular organization is coupled to function. To achieve this goal, a better understanding of organelle composition and structure is needed. Although visualization of cellular organelles using fluorescence or electron microscopy (EM) has become a common tool for the cel... | Advances in high-resolution imaging--techniques for three-dimensional imaging of cellular structures. |
{"1039": 0.5612884759902954, "1058": 0.16524957120418549, "2003": 0.20580662786960602, "2007": 0.18573370575904846, "2011": 0.1685553640127182, "2012": 0.3897167444229126, "2029": 0.15359249711036682, "2084": 0.013579257763922215, "2207": 0.24401791393756866, "2213": 0.10818854719400406, "2310": 0.24401791393756866, "2... | 9588931 | Vascular calcification is a strong independent predictor of increased cardiovascular morbidity and mortality and has a high prevalence among patients with chronic kidney disease. The present study investigated the effects of quercetin on vascular calcification caused by oxidative stress and abnormal mitochondrial dynam... | Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission. |
{"1017": 0.09050461649894714, "1018": 0.05786345899105072, "1019": 0.2470736801624298, "1043": 0.45994341373443604, "1049": 0.11343330889940262, "1052": 0.129004567861557, "1058": 0.26296505331993103, "1997": 0.025073638185858727, "2001": 0.013579257763922215, "2003": 0.25467249751091003, "2005": 0.07068414986133575, "... | 9591368 | The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today. In past years, studies on the entry of the virus into its host cell have led to the identification of a number of essential virus ... | The M/GP5 Glycoprotein Complex of Porcine Reproductive and Respiratory Syndrome Virus Binds the Sialoadhesin Receptor in a Sialic Acid-Dependent Manner |
{"1011": 0.14179791510105133, "1014": 0.7809720039367676, "1016": 0.29036402702331543, "1056": 0.7201237678527832, "1060": 0.4980490207672119, "2000": 0.0770333781838417, "2003": 0.02412080205976963, "2005": 0.27044451236724854, "2044": 0.3850763738155365, "2046": 0.24325250089168549, "2048": 0.48068851232528687, "2051... | 9599194 | With the recent availability of complete genomic sequences of many organisms, high-throughput and cost-efficient systems for gene cloning and functional analysis are in great demand. Although site-specific recombination-based cloning systems, such as Gateway cloning technology, are extremely useful for efficient transf... | A versatile zero background T-vector system for gene cloning and functional genomics. |
{"1011": 0.15693697333335876, "1015": 0.11865071207284927, "1020": 0.45251765847206116, "1041": 0.5027855634689331, "2004": 0.10467668622732162, "2005": 0.2976420819759369, "2008": 0.08603433519601822, "2011": 0.4177590310573578, "2029": 0.3883931338787079, "2058": 0.34715715050697327, "2076": 0.2231435477733612, "2079... | 9600826 | Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy. Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis. In this pathway, Arf6 is activated by EGFR via GEP100. Arf6 is highly expressed also in human... | GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis |
{"1011": 0.12986256182193756, "1023": 0.12728634476661682, "1039": 0.27934664487838745, "1046": 0.11778303235769272, "1999": 0.25995752215385437, "2003": 0.3824150264263153, "2004": 0.058784693479537964, "2007": 0.08782484382390976, "2015": 0.23247487843036652, "2075": 0.40806588530540466, "2078": 0.7647408246994019, "... | 9604301 | UNLABELLED Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and outcome. As in many infectious diseases, this variability is commonly assigned to host factors. To investigate whether the diversity of Cryptococcus neoformans clinical (ClinCn) isolates influences the interaction with ... | Dynamics of Cryptococcus neoformans-Macrophage Interactions Reveal that Fungal Background Influences Outcome during Cryptococcal Meningoencephalitis in Humans |
{"1011": 0.16110190749168396, "1015": 0.22001366317272186, "1016": 0.43244171142578125, "1017": 0.16690383851528168, "1044": 0.010684899985790253, "1048": 0.20818853378295898, "1052": 0.319873183965683, "1996": 0.1229778528213501, "1999": 0.11430477350950241, "2003": 0.06886265426874161, "2011": 0.26446542143821716, "2... | 9612317 | The angiopoietin-Tie2 system in endothelial cells is an important regulator of vasculogenesis and vascular integrity. High levels of angiopoietin-2 (Ang2) mRNA are observed in vascular activation during tumorigenesis. Although Ang2 is known to be a naturally occurring antagonist of angiopoietin-1 (Ang1) in vivo, the ex... | Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway |
{"1006": 0.0770333781838417, "1009": 0.272677481174469, "1011": 0.29981520771980286, "1018": 0.757441520690918, "1022": 0.6553317308425903, "1037": 0.4673144817352295, "1041": 0.4286321699619293, "1048": 1.1128336191177368, "1050": 0.7276995778083801, "1164": 0.33115679025650024, "2004": 0.5855054259300232, "2005": 0.0... | 9614443 | The anti-inflammatory eicosanoid lipoxin A(4) (LXA(4)), aspirin-triggered 15-epi-LXA(4), and their stable analogs down-regulate IL-8 secretion and subsequent recruitment of neutrophils by intestinal epithelia. In an effort to elucidate the mechanism by which these lipid mediators modulate cellular proinflammatory progr... | Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. |
{"1011": 0.06520967930555344, "1014": 0.14179791510105133, "1052": 0.04487626627087593, "2000": 0.13243216276168823, "2004": 0.13755162060260773, "2007": 0.20818853378295898, "2012": 0.14433705806732178, "2015": 0.1221139207482338, "2029": 0.053244512528181076, "2039": 0.19862671196460724, "2053": 0.14349138736724854, ... | 9617381 | OBJECTIVE To evaluate long-term prognostic effect of serum noncholesterol sterols, including plant sterols, in middle-aged men with high cardiovascular disease (CVD) risk, without statins at baseline. METHODS This was a prospective study of 232 men (mean age 60 years) at high risk of CVD in 1985-1986. Most were hyperch... | Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men. |
{"1011": 0.0038986403960734606, "1014": 0.1229778528213501, "1017": 0.11951763927936554, "1039": 0.24171993136405945, "1041": 0.3170322775840759, "1044": 0.791648268699646, "1048": 0.15860503911972046, "1051": 0.33325836062431335, "1052": 0.3676496744155884, "1055": 0.16690383851528168, "1081": 0.7276995778083801, "199... | 9622258 | RATIONALE Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studies have suggested that intracoronary administration of autologous cardiosphere-derived cells (CDCs) may improve ventricular function. OBJECTIVE The aim of this study was to test whether intracoronary delivery of CDC... | Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial. |
{"1011": 0.25239890813827515, "1017": 0.5662899017333984, "1019": 0.20739519596099854, "1040": 0.5415972471237183, "1041": 0.23402166366577148, "1043": 0.6332852244377136, "1046": 0.11951763927936554, "2000": 0.05417001247406006, "2003": 0.09495500475168228, "2005": 0.1064341589808464, "2007": 0.02792670577764511, "201... | 9629682 | The field of macro-imaging has grown considerably with the appearance of innovative clearing methods and confocal microscopes with lasers capable of penetrating increasing tissue depths. The ability to visualize and model the growth of whole organs as they develop from birth, or with manipulation, disease or injury, pr... | A Whole Brain Staining, Embedding, and Clearing Pipeline for Adult Zebrafish to Visualize Cell Proliferation and Morphology in 3-Dimensions |
{"1011": 0.33115679025650024, "1040": 0.26146242022514343, "1043": 0.6139179468154907, "1999": 0.1873544454574585, "2003": 0.2034190446138382, "2029": 0.20102575421333313, "2033": 0.7417513132095337, "2044": 0.03266380727291107, "2046": 0.30989447236061096, "2058": 0.5027855634689331, "2063": 0.1734936386346817, "2071"... | 9634465 | Direct reprogramming is a promising approach in regenerative medicine. Overexpression of the cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Hand2 (GHMT) directly reprogram fibroblasts into cardiomyocyte-like cells (iCMs). However, the critical timing of transgene expression and the molecular mec... | Single-Construct Polycistronic Doxycycline-Inducible Vectors Improve Direct Cardiac Reprogramming and Can Be Used to Identify the Critical Timing of Transgene Expression |
{"1011": 0.007782140281051397, "1016": 0.3662964701652527, "1047": 0.21372433006763458, "1048": 0.9455460906028748, "1054": 0.7683706283569336, "1061": 0.020300358533859253, "1155": 0.46670228242874146, "2003": 0.0606246218085289, "2015": 0.0029254043474793434, "2029": 0.1384023278951645, "2050": 0.28670501708984375, "... | 9638032 | Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules. Defective microtubule-based axonal transport is hypothesized to contribute to Parkinson's disease, bu... | Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations |
{"1013": 0.13499516248703003, "1015": 0.11865071207284927, "1023": 0.09406650811433792, "1041": 0.3824150264263153, "1043": 0.8492490649223328, "1052": 0.5074998140335083, "1054": 0.1685553640127182, "2005": 0.12038381397724152, "2025": 0.02887592278420925, "2029": 0.2822965085506439, "2041": 0.27342069149017334, "2043... | 9641846 | The ability of progenitor cells to exit the cell cycle is essential for proper embryonic development and homeostasis, but the mechanisms governing cell cycle exit are still not fully understood. Here, we tested the requirement for the retinoblastoma (Rb) protein and its family members p107 and p130 in G0/G1 arrest and ... | G1 arrest and differentiation can occur independently of Rb family function |
{"1011": 0.06246116757392883, "1020": 0.34300774335861206, "1041": 1.4274288415908813, "1061": 0.29109421372413635, "1996": 0.13243216276168823, "1997": 0.11951763927936554, "2004": 0.35813871026039124, "2005": 0.05970508232712746, "2008": 0.12642613053321838, "2011": 0.1913948506116867, "2019": 0.4487839937210083, "20... | 9646449 | The Drosophila gene eyeless (ey) encodes a transcription factor with both a paired domain and a homeodomain. It is homologous to the mouse Small eye (Pax-6) gene and to the Aniridia gene in humans. These genes share extensive sequence identity, the position of three intron splice sites is conserved, and these genes are... | Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. |
{"1003": 0.004870930220931768, "1011": 0.14264501631259918, "1015": 0.34922540187835693, "1039": 0.38174858689308167, "1050": 0.678885817527771, "1164": 0.3662964701652527, "1999": 0.06246116757392883, "2004": 0.053244512528181076, "2011": 0.26146242022514343, "2015": 0.77198725938797, "2029": 0.11604541540145874, "203... | 9648896 | Lung cancer is the leading cause of cancer-related mortality in humans worldwide. Moreover, the overall 5-year survival rate is only 15%. Pathologically almost 80% of all lung cancer cases are non-small cell lung cancer (NSCLC). Cancer-associated fibroblasts (CAFs) have been found to exist in a large number of NSCLCs. ... | mir-1-mediated paracrine effect of cancer-associated fibroblasts on lung cancer cell proliferation and chemoresistance. |
{"1022": 0.016465263441205025, "1041": 0.009718249551951885, "1052": 0.6353566646575928, "1055": 0.6512666940689087, "1997": 0.10906458646059036, "2005": 0.2652147710323334, "2013": 0.3170322775840759, "2015": 0.2637155055999756, "2029": 0.17020416259765625, "2047": 0.6872705817222595, "2093": 0.055094651877880096, "20... | 9650982 | To identify new genetic factors for colorectal cancer (CRC), we conducted a genome-wide association study in east Asians. By analyzing genome-wide data in 2,098 cases and 5,749 controls, we selected 64 promising SNPs for replication in an independent set of samples, inclu... | Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer |
{"1011": 0.34508460760116577, "1015": 0.2696990668773651, "1048": 1.02149498462677, "1050": 0.21922965347766876, "1056": 0.4849066734313965, "1156": 0.5450005531311035, "2003": 0.29255300760269165, "2008": 0.05139094591140747, "2015": 0.53589928150177, "2024": 0.41840189695358276, "2025": 0.1913948506116867, "2050": 0.... | 9655347 | BACKGROUND Long non-coding RNAs (lncRNAs) are a sub-class within non-coding RNA repertoire that have emerged as crucial regulators of the gene expression in various pathophysiological conditions. lncRNAs display remarkable versatility and wield their functions through interactions with RNA, DNA, or proteins. Accumulati... | Long non-coding RNAs as novel players in β cell function and type 1 diabetes |
{"1020": 0.0019512200960889459, "2000": 0.020300358533859253, "2007": 0.19622190296649933, "2039": 0.010684899985790253, "2060": 0.255429208278656, "2064": 0.04767346754670143, "2071": 0.3012613356113434, "2072": 0.2667117714881897, "2080": 0.2089812457561493, "2084": 0.49626702070236206, "2094": 0.4425300657749176, "2... | 9658390 | INTRODUCTION To assess whether respiratory intermediate care units (RICUs) are cost effective alternatives to intensive care units (ICUs) for patients with exacerbation of chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS Multi-centre, prospective, bottom-up cost study performed in 15 ICUs and 6 RICUs.... | Costs of the COPD. Differences between intensive care unit and respiratory intermediate care unit. |
{"1011": 0.25694093108177185, "1052": 0.9798521995544434, "2000": 0.056018441915512085, "2004": 0.018384648486971855, "2005": 0.272677481174469, "2007": 0.46853771805763245, "2008": 0.09850110858678818, "2029": 0.2837681770324707, "2073": 0.14349138736724854, "2076": 0.20102575421333313, "2079": 0.29473719000816345, "2... | 9669099 | Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we describe binding of p53 also to regions located distantly from any known p53 target gene. I... | eRNAs are required for p53-dependent enhancer activity and gene transcription. |
{"1011": 0.0842406153678894, "1018": 0.2089812457561493, "1039": 0.28450319170951843, "1047": 0.6492279767990112, "2000": 0.020300358533859253, "2004": 0.19381128251552582, "2005": 0.1873544454574585, "2007": 0.18167030811309814, "2008": 0.11430477350950241, "2015": 0.35813871026039124, "2022": 0.037378571927547455, "2... | 9675944 | Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various therapeutic and research applications. However, several problems remain for th... | Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. |
{"1011": 0.21372433006763458, "1016": 0.04860413447022438, "1017": 0.176772341132164, "1039": 0.4113073945045471, "1041": 0.8135309815406799, "1045": 0.4914994537830353, "1048": 0.36967599391937256, "1057": 0.8143964409828186, "1999": 0.018384648486971855, "2002": 0.7482418417930603, "2005": 0.15526613593101501, "2006"... | 9680193 | The ubiquitin-binding protein Hrs and endosomal sorting complex required for transport (ESCRT)-I and ESCRT-III are involved in sorting endocytosed and ubiquitinated receptors to lysosomes for degradation and efficient termination of signaling. In this study, we have investigated the role of the ESCRT-II subunit Vps22/E... | Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. |
{"1011": 0.46363574266433716, "1043": 0.7863243818283081, "1056": 0.6629094481468201, "1060": 0.7537717819213867, "2007": 0.2881702482700348, "2011": 0.20421554148197174, "2029": 0.20660123229026794, "2033": 0.8666408061981201, "2071": 0.2674594223499298, "2094": 0.37371641397476196, "2099": 0.5127768516540527, "2159":... | 9687772 | Mutations in the human XPG gene give rise to an inherited photosensitive disorder, xeroderma pigmentosum (XP) associated with Cockayne syndrome (XP-G/CS). The clinical features of CS in XP-G/CS patients are difficult to explain on the basis of a defect in nucleotide excision repair (NER). We found that XPG forms a stab... | XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients. |
{"1051": 0.22392450273036957, "1997": 0.21530038118362427, "2011": 0.21372433006763458, "2013": 0.40546512603759766, "2015": 0.15023678541183472, "2028": 0.10993985831737518, "2029": 0.04487626627087593, "2069": 0.1332872211933136, "2071": 0.0029254043474793434, "2076": 0.018384648486971855, "2079": 0.08782484382390976... | 9696379 | Oscillations in patterns of expression of a large fraction of yeast genes are associated with the "metabolic cycle," usually seen only in prestarved, continuous cultures of yeast. We used FISH of mRNA in individual cells to test the hypothesis that these oscillations happen in single cells drawn from unsynchronized cul... | Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate. |
{"1007": 0.06977381557226181, "1021": 0.0174254160374403, "1043": 0.3956514894962311, "1061": 1.1689931154251099, "2003": 0.1602703034877777, "2008": 0.1358480453491211, "2011": 0.16110190749168396, "2029": 0.3241194784641266, "2072": 0.04394211992621422, "2100": 0.49030399322509766, "2109": 0.11691460013389587, "2116"... | 9704467 | We developed the Yeast Gene Order Browser (YGOB; http://wolfe.gen.tcd.ie/ygob) to facilitate visual comparisons and computational analysis of synteny relationships in yeasts. The data presented in YGOB, currently covering seven species, are based on sets of homologous genes that have been intensively manually curated b... | in polyploid species |
{"1011": 0.03266380727291107, "1038": 0.7683706283569336, "1042": 0.3560888469219208, "1048": 0.4093637466430664, "1055": 0.43244171142578125, "1996": 0.10467668622732162, "2003": 0.0038986403960734606, "2004": 0.06703783571720123, "2005": 0.04394211992621422, "2011": 0.18654440343379974, "2013": 0.32058215141296387, "... | 9705208 | Subcapsular sinus (SCS) macrophages capture antigens from lymph and present them intact for B cell encounter and follicular delivery. However, the properties of SCS macrophages are poorly defined. Here we show SCS macrophage development depended on lymphotoxin-alpha1beta2, and the cells had low lysosomal enzyme express... | Immune complex relay by subcapsular sinus macrophages and non-cognate B cells drives antibody affinity maturation |
{"1042": 0.09228714555501938, "1056": 1.0782235860824585, "2011": 0.2247048318386078, "2015": 0.040196798741817474, "2028": 0.12642613053321838, "2037": 0.07068414986133575, "2046": 0.39367714524269104, "2064": 0.3283478021621704, "2071": 0.0770333781838417, "2075": 0.35334911942481995, "2076": 0.1946154683828354, "207... | 9724974 | Numerous transcription factors (TFs) encode information about upstream signals in the dynamics of their activation, but how downstream genes decode these dynamics remains poorly understood. Using microfluidics to control the nucleocytoplasmic translocation dynamics of the budding yeast TF Msn2, we elucidate the princip... | Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression |
{"1011": 0.28670501708984375, "1014": 0.11343330889940262, "1017": 0.5364705324172974, "1040": 0.3170322775840759, "1041": 0.24248650670051575, "1043": 0.13755162060260773, "1050": 0.4002431631088257, "1052": 0.5990082025527954, "1058": 0.6980181336402893, "1997": 0.11256109178066254, "2015": 0.6254787445068359, "2019"... | 9730755 | Arrays of III-V direct-bandgap semiconductor nanopillars represent promising photovoltaic candidates due to their inherent high optical absorption coefficients and minimized reflection arising from light trapping, efficient charge collection in the radial direction and the ability to synthesize them on low-cost platfor... | GaAs nanopillar-array solar cells employing in situ surface passivation |
{"1009": 0.2969166338443756, "1011": 0.15777134895324707, "1019": 0.08692999184131622, "1020": 0.07793712615966797, "1043": 0.613389253616333, "1044": 0.3241194784641266, "1055": 0.6233867406845093, "2010": 1.102510929107666, "2011": 0.3012613356113434, "2012": 0.8135309815406799, "2015": 0.29400965571403503, "2029": 0... | 9732010 | Histone acetyltransferases (HATs) and ATP-dependent chromatin remodeling factors (ADCRs) are involved in selective gene regulation via modulation of local chromatin configuration. Activation of the recombination hotspot ade6-M26 of Schizosaccharomyces pombe is mediated by a cAMP responsive element (CRE)-like sequence, ... | Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. |
{"1011": 0.3325583338737488, "1041": 0.6363908052444458, "1043": 0.9470623731613159, "1052": 0.0058422754518687725, "1056": 0.24248650670051575, "2007": 0.04767346754670143, "2008": 0.0029254043474793434, "2029": 0.09938567131757736, "2057": 0.0058422754518687725, "2061": 0.820433497428894, "2064": 0.2652147710323334, ... | 9737083 | We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are show... | The Somatic Genomic Landscape of Glioblastoma |
{"1011": 0.06246116757392883, "1018": 0.10203468054533005, "1020": 0.1221139207482338, "1044": 0.12038381397724152, "1049": 0.11430477350950241, "1050": 0.037378571927547455, "1056": 0.16524957120418549, "2005": 0.007782140281051397, "2007": 0.014542185701429844, "2039": 0.0019512200960889459, "2044": 0.687270581722259... | 9745001 | OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an in... | Radioiodine treatment of multinodular non-toxic goitre. |
{"1009": 0.33605360984802246, "1011": 0.2561853528022766, "1016": 0.23633737862110138, "2011": 0.13414156436920166, "2015": 0.1221139207482338, "2020": 0.02316705882549286, "2029": 0.06612417846918106, "2037": 0.08513788133859634, "2050": 0.5914691090583801, "2073": 0.01934296265244484, "2087": 0.13157635927200317, "20... | 9748934 | Neurodegenerative diseases, such as frontotemporal dementia (FTD), are often associated with behavioral deficits, but the underlying anatomical and molecular causes remain poorly understood. Here we show that forebrain-specific expression of FTD-associated mutant CHMP2B in mice causes several age-dependent neurodegener... | Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia |
{"1011": 0.306306391954422, "1013": 0.11691460013389587, "1015": 0.5301685929298401, "1016": 0.1358480453491211, "1017": 0.32270604372024536, "1041": 0.6739205718040466, "1043": 0.2447827309370041, "1048": 0.47584590315818787, "1050": 0.12642613053321838, "1060": 0.7987030148506165, "1998": 0.17922431230545044, "2007":... | 9752604 | In light of the emerging interplay between redox and metabolic signaling pathways we investigated the potential cross talk between nuclear factor E2-related factor 2 (Nrf2) and AMP-activated kinase (AMPK), central regulators of the cellular redox and energy balance, respectively. Making use of xanthohumol (XN) as an ac... | Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response |
{"1037": 0.026976587250828743, "1057": 0.1212492436170578, "1998": 0.18573370575904846, "2038": 0.14264501631259918, "2045": 0.20102575421333313, "2047": 0.5833279490470886, "2048": 0.018384648486971855, "2064": 0.11951763927936554, "2071": 0.053244512528181076, "2079": 0.009718249551951885, "2090": 0.0913962796330452,... | 9754530 | Like other branches of surgery, Urology has encountered major challenges in aligning the research processes by which new interventions are assessed with the principles of Evidence-Based Medicine. This article explains the IDEAL framework and recommendations and illustrates how they might affect the evaluation of curren... | The IDEAL recommendations and urological innovation |
{"1016": 0.42735910415649414, "1020": 0.29036402702331543, "1052": 0.18248429894447327, "1053": 0.08603433519601822, "2000": 0.04113444685935974, "2001": 0.18978065252304077, "2005": 0.08871890604496002, "2007": 0.23247487843036652, "2028": 0.055094651877880096, "2034": 0.2837681770324707, "2039": 0.23015019297599792, ... | 9754833 | OBJECTIVES To evaluate the effects of early lumbar disc surgery compared with prolonged conservative care for patients with sciatica over two years of follow-up. DESIGN Randomised controlled trial. SETTING Nine Dutch hospitals. PARTICIPANTS 283 patients with 6-12 weeks of sciatica. INTERVENTIONS Early surgery or an int... | Prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disc herniation: two year results of a randomised controlled trial. |
{"1009": 0.36426326632499695, "1014": 0.684319257736206, "1017": 0.30989447236061096, "1020": 0.14264501631259918, "1039": 0.040196798741817474, "1044": 0.0770333781838417, "1052": 0.28743788599967957, "1058": 0.12814582884311676, "2001": 0.1619328260421753, "2005": 0.06337817758321762, "2011": 0.04487626627087593, "20... | 9764256 | BACKGROUND Human papillomavirus (HPV) testing is more sensitive for the detection of high-grade cervical lesions than is cytology, but detection of HPV by DNA screening in two screening rounds 5 years apart has not been assessed. The aim of this study was to assess whether HPV DNA testing in the first screen decreases ... | Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomised controlled trial. |
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