spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1009": 0.4425300657749176, "1019": 0.029824240133166313, "1040": 0.4794800877571106, "1041": 1.1882244348526, "1043": 0.4151833653450012, "1045": 0.29255300760269165, "1051": 0.9076598286628723, "1056": 0.42608439922332764, "1062": 0.19541899859905243, "1155": 0.28082266449928284, "2003": 0.04860413447022438, "2005":... | 9767444 | Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an immune suppressive microenvironment, and response of ovarian cancers to immune therapies has thus far been disappointing. We now find, in a m... | Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden. |
{"1016": 0.32058215141296387, "1023": 0.46853771805763245, "1045": 0.9394577741622925, "1997": 0.011650617234408855, "1999": 0.02316705882549286, "2008": 0.0770333781838417, "2011": 0.07341018319129944, "2013": 0.20977331697940826, "2028": 0.40806588530540466, "2029": 0.31560876965522766, "2034": 0.24325250089168549, "... | 9769310 | The phenomenon of parental imprinting involves the preferential expression of one parental allele of a subset of chromosomal genes and has so far only been documented in the mouse. We show here, by exploiting sequence polymorphisms in exon nine of the human insulin–like growth factor 2 (IGF2) gene, that only the patern... | IGF2 is parentally imprinted during human embryogenesis and in the Beckwith–Wiedemann syndrome |
{"1015": 0.5186077356338501, "1017": 0.015504186972975731, "1019": 0.0752234235405922, "1045": 0.3325583338737488, "1050": 0.4041621685028076, "1056": 0.6112717390060425, "2001": 0.02887592278420925, "2003": 0.02412080205976963, "2005": 0.15023678541183472, "2006": 0.24171993136405945, "2020": 0.04674193635582924, "202... | 9769684 | BACKGROUND Radio Frequency Identification (RFID) devices are becoming more and more essential for patient safety in hospitals. The purpose of this study was to determine patient safety, data reliability and signal loss wearing on skin RFID devices during magnetic resonance imaging (MRI) and computed tomography (CT) sca... | Safety and reliability of Radio Frequency Identification Devices in Magnetic Resonance Imaging and Computed Tomography |
{"1011": 0.04487626627087593, "1048": 0.9613537192344666, "1054": 0.47584590315818787, "1060": 1.3128622770309448, "2002": 0.23556606471538544, "2003": 0.040196798741817474, "2008": 0.07159364968538284, "2011": 0.24631060659885406, "2024": 0.16110190749168396, "2029": 0.08871890604496002, "2079": 0.11430477350950241, "... | 9784254 | The liver X receptors (LXRs) are nuclear receptors with established roles in the regulation of lipid metabolism. We now show that LXR signaling not only regulates macrophage cholesterol metabolism but also impacts antimicrobial responses. Mice lacking LXRs are highly susceptible to infection with the intracellular bact... | LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response |
{"1009": 0.5415972471237183, "1011": 0.21372433006763458, "1016": 0.05139094591140747, "1017": 0.053244512528181076, "1019": 0.2741633653640747, "1038": 1.0207915306091309, "1039": 0.08961215615272522, "1042": 0.06154331564903259, "1045": 0.6548244953155518, "1048": 0.026025565341114998, "1052": 0.19381128251552582, "2... | 9787715 | BACKGROUND The effects of Plasmodium falciparum on B-cell homeostasis have not been well characterized. This study investigated whether an episode of acute malaria in young children results in changes in the peripheral B cell phenotype. METHODS Using flow-cytofluorimetric analysis, the B cell phenotypes found in the pe... | Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children |
{"1011": 0.06154331564903259, "1016": 0.1889725625514984, "1017": 0.2317005842924118, "1044": 0.2837681770324707, "1048": 0.009718249551951885, "2005": 0.10203468054533005, "2008": 0.13071982562541962, "2010": 0.981317400932312, "2011": 0.015504186972975731, "2029": 0.19541899859905243, "2034": 0.306306391954422, "2038... | 9791313 | In the past decade important progress has been made in our understanding of the epigenetic regulatory machinery. It has become clear that genetic aberrations in multiple epigenetic modifier proteins are associated with various types of cancer. Moreover, targeting the epigenome has emerged as a novel tool to treat cance... | SETD2: an epigenetic modifier with tumor suppressor functionality |
{"1003": 0.45870962738990784, "1043": 0.42735910415649414, "1996": 0.272677481174469, "1997": 0.08871890604496002, "1999": 0.04487626627087593, "2006": 0.1602703034877777, "2011": 0.29981520771980286, "2015": 0.3339579105377197, "2029": 0.24171993136405945, "2049": 0.025073638185858727, "2051": 0.1229778528213501, "206... | 9796495 | The brain's energy supply determines its information processing power, and generates functional imaging signals. The energy use on the different subcellular processes underlying neural information processing has been estimated previously for the grey matter of the cerebral and cerebellar cortex. However, these estimate... | Updated energy budgets for neural computation in the neocortex and cerebellum. |
{"1014": 0.27342069149017334, "1044": 0.32905077934265137, "1052": 0.2607102394104004, "1999": 0.3416208028793335, "2003": 0.151916041970253, "2007": 0.20421554148197174, "2015": 0.029824240133166313, "2022": 0.11691460013389587, "2026": 0.5528968572616577, "2031": 0.1229778528213501, "2038": 0.07793712615966797, "2043... | 9813098 | Young patients with an ischaemic stroke or transient ischaemic attack (TIA) often have no vascular risk factors. Hyperhomocysteinaemia is an established risk factor for stroke in elderly patients but it is uncertain whether it is also important for the prognosis of young ischaemic stroke and TIA patients. We examined t... | Plasma homocysteine is a risk factor for recurrent vascular events in young patients with an ischaemic stroke or TIA |
{"1011": 0.29981520771980286, "1013": 0.04674193635582924, "1016": 0.056018441915512085, "1037": 0.04860413447022438, "1041": 0.19541899859905243, "1045": 0.5393219590187073, "1048": 0.27564704418182373, "1999": 0.24859806895256042, "2005": 0.011650617234408855, "2007": 0.28890204429626465, "2011": 0.46117570996284485,... | 9814332 | Although the accumulation of cholesterol in macrophages appears to be an initial step in atherogenesis, low-density lipoprotein (LDL), a major risk factor for atherosclerosis, does not promote cholesterol accumulation in macrophages in its native form. On the other hand, apolipoprotein (apo) A-I-containing lipoprotein ... | LDL inhibits the mediation of cholesterol efflux from macrophage foam cells by apoA-I-containing lipoproteins. A putative mechanism for foam cell formation. |
{"1016": 0.6165571808815002, "1018": 0.00875066313892603, "1028": 0.06886265426874161, "2004": 0.24325250089168549, "2015": 0.020300358533859253, "2044": 0.08871890604496002, "2058": 0.07068414986133575, "2062": 0.304147332906723, "2064": 0.10555581003427505, "2066": 0.08603433519601822, "2076": 0.13414156436920166, "2... | 9822397 | CONTEXT Sugar-sweetened beverages like soft drinks and fruit punches contain large amounts of readily absorbable sugars and may contribute to weight gain and an increased risk of type 2 diabetes, but these relationships have been minimally addressed in adults. OBJECTIVE To examine the association between consumption of... | Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. |
{"1011": 0.10993985831737518, "1039": 0.2247048318386078, "1052": 0.2576959431171417, "2007": 0.05970508232712746, "2010": 0.637939989566803, "2015": 0.0058422754518687725, "2029": 0.11256109178066254, "2030": 0.3777405619621277, "2050": 0.23247487843036652, "2076": 0.0009760859538801014, "2079": 0.083342544734478, "20... | 9831859 | Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer... | Pancreatic stellate cells: partners in crime with pancreatic cancer cells. |
{"1009": 0.48670899868011475, "1014": 0.18248429894447327, "1018": 0.09761575609445572, "1019": 0.10993985831737518, "1020": 0.49626702070236206, "1021": 0.23710809648036957, "1022": 0.3723714053630829, "1023": 0.22157983481884003, "1037": 0.15359249711036682, "1038": 0.3923587501049042, "1044": 0.0174254160374403, "10... | 9846940 | OBJECTIVE To determine if preoperative statin treatment is associated with a reduction in systemic inflammatory response (SIR) and myocardial damage markers following cardiac surgery with cardiopulmonary bypass (CPB). METHODS We study a prospective cohort of 138 patients who underwent coronary and valvular surgery with... | Preoperative statin treatment reduces systemic inflammatory response and myocardial damage in cardiac surgery. |
{"1012": 0.15526613593101501, "1041": 0.016465263441205025, "1049": 0.6916812658309937, "1060": 0.083342544734478, "2003": 0.2741633653640747, "2005": 0.22626367211341858, "2006": 0.15610189735889435, "2008": 0.08782484382390976, "2024": 0.015504186972975731, "2038": 0.06429435312747955, "2042": 0.011650617234408855, "... | 9872468 | We present the latest version of the Molecular Evolutionary Genetics Analysis (Mega) software, which contains many sophisticated methods and tools for phylogenomics and phylomedicine. In this major upgrade, Mega has been optimized for use on 64-bit computing systems for analyzing larger datasets. Researchers can now ex... | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. |
{"2003": 0.2576959431171417, "2054": 0.16276304423809052, "2182": 0.08154398202896118, "2239": 0.37640097737312317, "2334": 0.28450319170951843, "2339": 0.46853771805763245, "2389": 0.14518201351165771, "2427": 0.2763880789279938, "2430": 0.40546512603759766, "2469": 0.06246116757392883, "2470": 0.2719337046146393, "25... | 9875570 | DNA replication fidelity is a key determinant of genome stability and is central to the evolution of species and to the origins of human diseases. Here we review our current understanding of replication fidelity, with emphasis on structural and biochemical studies of DNA polymerases that provide new insights into the i... | DNA replication fidelity |
{"1011": 0.17020416259765625, "1019": 0.18492233753204346, "1039": 0.469759464263916, "1043": 0.04860413447022438, "1050": 0.07341018319129944, "1056": 0.469759464263916, "1996": 0.08244366943836212, "2003": 0.11168810725212097, "2007": 0.05046287178993225, "2008": 0.012615402229130268, "2011": 0.49626702070236206, "20... | 9878167 | Neutrophil extracellular traps (NETs) represent extracellular structures able to bind and kill microorganisms. It is believed that they are generated by neutrophils undergoing cell death, allowing these dying or dead cells to kill microbes. We show that, following priming with granulocyte/macrophage colony-stimulating ... | Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps |
{"1011": 0.19782574474811554, "1015": 0.28670501708984375, "1016": 0.25467249751091003, "1044": 0.8845420479774475, "1055": 0.567397952079773, "1059": 0.09938567131757736, "1062": 0.10291612148284912, "1999": 0.11951763927936554, "2002": 0.21372433006763458, "2003": 0.040196798741817474, "2005": 0.06337817758321762, "2... | 9881829 | The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphospha... | ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. |
{"1011": 0.4228905141353607, "1016": 0.09584271162748337, "1017": 0.30989447236061096, "1039": 0.11604541540145874, "1044": 0.5941681861877441, "1052": 0.2786078155040741, "1056": 0.04767346754670143, "1062": 0.7445381283760071, "1997": 0.25694093108177185, "1998": 0.2105647772550583, "1999": 0.055094651877880096, "200... | 9889151 | FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic regions near the C termini of each subunit. Mutations throughout these regions affect binding and cause correlated phenotypes that range from mild ... | FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs. |
{"1016": 0.7408206462860107, "1047": 0.04860413447022438, "1049": 0.3381449282169342, "1999": 0.04394211992621422, "2002": 0.6950984001159668, "2003": 0.5506471395492554, "2005": 0.5557019114494324, "2011": 0.2954642176628113, "2048": 0.3526630103588104, "2053": 0.029824240133166313, "2079": 0.14264501631259918, "2109"... | 9899292 | Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and increased glucose utilization. Metformin's beneficial effects on circulating lipids have been linked to reduced fatty liver. AM... | Role of AMP-activated protein kinase in mechanism of metformin action. |
{"1011": 0.08782484382390976, "1014": 0.0770333781838417, "1020": 0.04394211992621422, "1038": 0.8674615025520325, "1041": 0.22001366317272186, "1044": 0.3560888469219208, "1045": 0.16359257698059082, "1052": 0.025073638185858727, "1056": 0.05139094591140747, "1999": 0.6233867406845093, "2002": 1.1128336191177368, "200... | 9904546 | BACKGROUND & AIMS Treatment of chronic hepatitis B with interferon alfa is not approved in children. The aim of this study was to evaluate the safety and efficacy of interferon alfa (IFN-alpha) in children with chronic hepatitis B and increased transaminase levels. METHODS Children were given either IFN-alpha2b (6 mega... | Interferon alfa therapy for chronic hepatitis B in children: a multinational randomized controlled trial. |
{"1011": 0.05046287178993225, "1056": 1.1689931154251099, "2003": 0.04767346754670143, "2011": 0.07884006202220917, "2015": 0.31132611632347107, "2024": 0.20739519596099854, "2050": 0.33953672647476196, "2079": 0.00875066313892603, "2099": 0.33675122261047363, "2109": 0.12814582884311676, "2114": 0.6228629946708679, "2... | 9909405 | Overcoming immunosuppression and activating a cytotoxic T cell response has the potential to halt the progression of cancer and, in some circumstances, eradicate it. Designing therapeutic interventions that achieve this goal has proven challenging, but now a greater understanding of the complexities of immune responses... | ImmTACs for targeted cancer therapy: Why, what, how, and which. |
{"1011": 0.20580662786960602, "1017": 0.26446542143821716, "1044": 0.0058422754518687725, "1996": 0.0174254160374403, "1999": 0.12986256182193756, "2004": 0.12384103983640671, "2011": 0.026025565341114998, "2019": 0.053244512528181076, "2029": 0.34715715050697327, "2046": 0.22937409579753876, "2058": 0.2778684496879577... | 9911547 | The physiologic roles of angiopoietin-like proteins (Angptls) in the hematopoietic system remain unknown. Here we show that hematopoietic stem cells (HSCs) in Angptl3-null mice are decreased in number and quiescence. HSCs transplanted into Angptl3-null recipient mice exhibited impaired repopulation. Bone marrow sinusoi... | Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche. |
{"1056": 1.0655186176300049, "2000": 0.034552380442619324, "2005": 0.31132611632347107, "2007": 0.40611594915390015, "2029": 0.10467668622732162, "2048": 0.36900100111961365, "2064": 0.3601844012737274, "2109": 0.1384023278951645, "2114": 0.037378571927547455, "2168": 0.04207121208310127, "2182": 0.06886265426874161, "... | 9929089 | BACKGROUND Patients with advanced or metastatic non-small cell lung cancer (NSCLC) can develop acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) erlotinib and gefitinib. Here, we report the successful treatment with alternating chemotherapy and TKIs of two cases of advanced NSCLC... | Subsequent chemotherapy reverses acquired tyrosine kinase inhibitor resistance and restores response to tyrosine kinase inhibitor in advanced non-small-cell lung cancer |
{"1011": 0.14179791510105133, "1040": 0.8289952278137207, "1056": 0.7546905279159546, "1156": 0.29619070887565613, "2003": 0.036437395960092545, "2005": 0.417115718126297, "2007": 0.3850763738155365, "2010": 0.9256220459938049, "2026": 0.7239188551902771, "2072": 0.7592713832855225, "2078": 0.7737906575202942, "2109": ... | 9955779 | Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune therapy. Herein, pharmacologic and isoform specificity of HDACis are investigated to guide their addition to a DNMTi, thus devising a new, low-dose, seque... | Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer |
{"1011": 0.08692999184131622, "1038": 0.18004031479358673, "1043": 0.05786345899105072, "1045": 0.31132611632347107, "1046": 0.7398891448974609, "1050": 0.5370414853096008, "1051": 0.7028654217720032, "1052": 0.678390383720398, "1155": 0.18492233753204346, "1157": 0.08064348995685577, "1164": 0.4093637466430664, "2005"... | 9956893 | OBJECTIVE Advances made in the past ten years highlight the notion that peroxisome proliferator-activated receptors gamma (PPARγ) has protective properties in the pathophysiology of osteoarthritis (OA). The aim of this study was to define the roles of PPARγ in AGEs-induced inflammatory response in human chondrocytes. M... | The Role of PPARγ in Advanced Glycation End Products-Induced Inflammatory Response in Human Chondrocytes |
{"1018": 0.08782484382390976, "1026": 0.0058422754518687725, "1040": 0.1913948506116867, "1052": 0.36494144797325134, "2000": 0.06520967930555344, "2001": 0.1734936386346817, "2004": 0.35060185194015503, "2005": 0.24018502235412598, "2007": 0.3077431619167328, "2011": 0.1946154683828354, "2020": 0.10026945173740387, "2... | 9967265 | BACKGROUND Patent ductus arteriosus (PDA) with significant left to right shunt in preterm infants increases morbidity and mortality. Early closure of the ductus arteriosus may be achieved pharmacologically using cyclooxygenase inhibitors or by surgery. The efficacy of both treatment modalities is well established. Howe... | Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. |
{"1011": 0.13670019805431366, "1014": 0.45437926054000854, "1017": 0.08871890604496002, "1019": 0.0606246218085289, "2000": 0.15777134895324707, "2001": 0.0009760859538801014, "2007": 0.13071982562541962, "2015": 0.2105647772550583, "2029": 0.01934296265244484, "2046": 0.3084607720375061, "2048": 0.5336109399795532, "2... | 9973014 | Purpose. To demonstrate how correlations among predictor variables in a population pharmacokinetic model affect the ability to discern which covariates should enter into the structural pharmacokinetic model. Methods. Monte Carlo simulation was used to generate multiple-dose concentration-time data similar to that seen ... | The Effect of Collinearity on Parameter Estimates in Nonlinear Mixed Effect Models |
{"1003": 0.11517547070980072, "1014": 0.17759032547473907, "1998": 0.0752234235405922, "2005": 0.009718249551951885, "2007": 0.28963330388069153, "2015": 0.09228714555501938, "2018": 0.1229778528213501, "2020": 0.16359257698059082, "2022": 0.05786345899105072, "2035": 0.1685553640127182, "2037": 0.036437395960092545, "... | 9976969 | Psychiatric illness is a significant risk factor for both attempted and completed suicide and psychotropic medications account for 80% of all drug overdoses involving prescription medications. One challenge facing clinicians is to balance the benefit of treatment against the risk of drug overdose. The aim of the presen... | An analysis of age and gender influences on the relative risk for suicide and psychotropic drug self-poisoning. |
{"1051": 0.4950772523880005, "1996": 0.00875066313892603, "1998": 0.20580662786960602, "2000": 0.24325250089168549, "2015": 0.34370049834251404, "2021": 0.058784693479537964, "2045": 0.10467668622732162, "2054": 0.20022670924663544, "2064": 0.37371641397476196, "2070": 0.11691460013389587, "2071": 0.00875066313892603, ... | 9977329 | The host response to pathogens involves complex inflammatory responses and immune reactions. While these are central to host defense and vital to clearing infections, they are often accompanied by injury to surrounding tissue. Most organ systems can tolerate these responses without permanent consequences. However, ther... | Cell death and immune privilege. |
{"1011": 0.19862671196460724, "1016": 0.26146242022514343, "1041": 0.8682814836502075, "1042": 0.6970458030700684, "1043": 0.5914691090583801, "1997": 0.025073638185858727, "2004": 0.31845372915267944, "2005": 0.04207121208310127, "2011": 0.3757305145263672, "2013": 0.3547199070453644, "2015": 0.02792670577764511, "202... | 9988425 | Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions. Ex vivo expansion of pure populations of tissue stem cells has pr... | Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell |
{"1011": 0.17020416259765625, "1018": 0.13071982562541962, "1044": 0.7248653769493103, "1048": 0.4734157919883728, "1056": 0.7220231294631958, "1996": 0.05417001247406006, "1997": 0.045809537172317505, "1999": 0.083342544734478, "2002": 0.07068414986133575, "2010": 0.8853482007980347, "2015": 0.012615402229130268, "202... | 9993008 | The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key regulatory controls involved in development. We explored this by examining histone meth... | A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells |
{"1011": 0.2516399025917053, "1016": 0.45499902963638306, "1017": 0.09672962874174118, "1018": 0.3810817003250122, "1042": 0.4093637466430664, "1043": 0.6492279767990112, "1047": 0.8004589080810547, "1051": 0.9425065517425537, "1996": 0.004870930220931768, "1997": 0.009718249551951885, "1999": 0.2983669638633728, "2005... | 9997636 | The aim of this study was to confirm the presence of stem cells in the ovarian surface epithelium of patients with premature ovarian failure and no mature follicles and oocytes. In these patients, small round cells of unknown origin expressing SOX-2 marker of pluripotency were observed among the epithelial cells just a... | Ovarian Surface Epithelium in Patients with Severe Ovarian Infertility: A Potential Source of Cells Expressing Markers of Pluripotent/Multipotent Stem Cells |
{"1996": 0.1889725625514984, "2034": 0.1602703034877777, "2037": 0.5844172835350037, "2043": 0.16359257698059082, "2049": 0.3269403576850891, "2076": 0.36967599391937256, "2079": 0.13071982562541962, "2083": 0.3019835948944092, "2090": 0.48430517315864563, "2110": 0.3409265875816345, "2126": 0.42096930742263794, "2129"... | 10009203 | As the nervous system develops, there is an inherent variability in the connections formed between differentiating neurons. Despite this variability, neural circuits form that are functional and remarkably robust. One way in which neurons deal with variability in their inputs is through compensatory, homeostatic change... | Structural Homeostasis: Compensatory Adjustments of Dendritic Arbor Geometry in Response to Variations of Synaptic Input |
{"1998": 0.25995752215385437, "2000": 0.26146242022514343, "2005": 0.26820653676986694, "2015": 0.8641747236251831, "2044": 0.791648268699646, "2054": 0.006812678650021553, "2055": 0.43623676896095276, "2064": 0.23787821829319, "2076": 0.5941681861877441, "2079": 0.32270604372024536, "2096": 0.0770333781838417, "2137":... | 10010651 | Cancer survivors are often highly motivated to seek information about food choices, physical activity, and dietary supplements to improve their treatment outcomes, quality of life, and overall survival. To address these concerns, the American Cancer Society (ACS) convened a group of experts in nutrition, physical activ... | Nutrition and physical activity guidelines for cancer survivors. |
{"1011": 0.08871890604496002, "1048": 0.38574060797691345, "1057": 0.6260011196136475, "2004": 0.0174254160374403, "2007": 0.04953393340110779, "2011": 0.31560876965522766, "2043": 0.0354953333735466, "2058": 0.1011524572968483, "2075": 0.8400169610977173, "2076": 0.5517725944519043, "2079": 0.13071982562541962, "2083"... | 10012166 | The ability to maintain a functional proteome, or proteostasis, declines during the ageing process. Damaged and misfolded proteins accumulate with age, impairing cell function and tissue homeostasis. The accumulation of damaged proteins contributes to multiple age-related diseases such as Alzheimer's, Parkinson's or Hu... | The role of protein clearance mechanisms in organismal ageing and age-related diseases. |
{"1011": 0.06795065850019455, "1042": 0.5127768516540527, "1044": 0.09317722171545029, "1052": 0.6043586730957031, "2002": 0.026976587250828743, "2004": 0.4770587682723999, "2007": 0.02887592278420925, "2011": 0.036437395960092545, "2029": 0.23556606471538544, "2037": 0.08961215615272522, "2044": 0.12556517124176025, "... | 10015292 | Highly regenerative tissues such as blood must possess effective DNA damage responses (DDR) that balance long-term regeneration with protection from leukemogenesis. Hematopoietic stem cells (HSCs) sustain life-long blood production, yet their response to DNA damage remains largely unexplored. We report that human HSCs ... | A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. |
{"1019": 0.08244366943836212, "1044": 0.2034190446138382, "1059": 0.9500881433486938, "1061": 1.0601204633712769, "2007": 0.018384648486971855, "2029": 0.2881702482700348, "2038": 0.03266380727291107, "2051": 0.02316705882549286, "2053": 0.39762192964553833, "2066": 0.12728634476661682, "2075": 0.3070250153541565, "207... | 10017612 | An extensive behavioral characterization was conducted with mice lacking the gene for neuropeptide Y (NPY) including response to 24 and 48 h fast and challenge with small molecule antagonists of NPY receptors implicated in mediating the feeding effects of NPY (i.e., Y1 and Y5). In addition, wildtype (WT) and NPY knocko... | Behavioral characterization of neuropeptide Y knockout mice. |
{"1011": 0.3995884954929352, "1014": 0.10026945173740387, "1021": 0.0354953333735466, "1050": 0.32341301441192627, "1052": 0.23092569410800934, "2005": 0.13157635927200317, "2007": 0.25694093108177185, "2008": 0.0606246218085289, "2029": 0.2184450328350067, "2036": 0.20421554148197174, "2058": 0.3499138653278351, "2064... | 10024681 | Deregulation of microRNA (miRNA) expression can have a critical role in carcinogenesis. Here we show in prostate cancer that miRNA-205 (miR-205) transcription is commonly repressed and the MIR-205 locus is hypermethylated. LOC642587, the MIR-205 host gene of unknown function, is also concordantly inactivated. We show t... | Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer |
{"1009": 0.21530038118362427, "1011": 0.03360854089260101, "1015": 0.09850110858678818, "1018": 0.32553088665008545, "1038": 0.500420093536377, "1040": 0.12470348179340363, "1048": 0.14349138736724854, "1049": 0.14179791510105133, "1998": 0.18654440343379974, "1999": 0.09938567131757736, "2007": 0.14686977863311768, "2... | 10029891 | In Major Depressive Disorder (MDD), the neuroendocrine and immune systems interactions are impaired. We investigated the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group. The MDD subjects showed higher levels of cortisol and TNF-alpha, increased CD3+CD8+ and NK percentag... | Th2 cytokine response in Major Depressive Disorder patients before treatment |
{"1011": 0.052318159490823746, "1012": 0.07612881064414978, "1039": 0.3283478021621704, "1040": 0.35677260160446167, "1054": 0.045809537172317505, "2003": 0.2689530849456787, "2073": 0.026976587250828743, "2092": 0.12642613053321838, "2094": 1.351516842842102, "2109": 0.021256839856505394, "2112": 0.29328158497810364, ... | 10029970 | CDD, the Conserved Domain Database, is part of NCBI's Entrez query and retrieval system and is also accessible via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml. CDD provides annotation of protein sequences with the location of conserved domain footprints and functional sites inferred from these footprints. Pre-c... | CDD: conserved domains and protein three-dimensional structure |
{"1011": 0.11951763927936554, "1040": 0.16690383851528168, "1045": 0.8212929964065552, "1999": 0.1064341589808464, "2008": 0.06886265426874161, "2029": 0.29473719000816345, "2031": 0.32764431834220886, "2038": 0.3526630103588104, "2061": 0.7683706283569336, "2062": 0.20501139760017395, "2087": 0.2822965085506439, "2091... | 10039688 | The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immu... | Extensive diversity of Ig-superfamily proteins in the immune system of insects. |
{"1006": 0.05786345899105072, "1011": 0.34715715050697327, "1015": 0.417115718126297, "1017": 0.2184450328350067, "1037": 0.7445381283760071, "1044": 0.6970458030700684, "1049": 0.7153595685958862, "1050": 0.5685047507286072, "1051": 0.6482070088386536, "1058": 0.6744182109832764, "1998": 0.018384648486971855, "2000": ... | 10068634 | BACKGROUND Late April 2009, human infection with variant influenza virus A(H1N1)v emerged in the Northern Americas posing a threat that this virus may become the next pandemic influenza virus. OBJECTIVES To prepare laboratories for surge capacity for molecular diagnosis of patients suspected for A(H1N1)v infection in t... | Preparing the outbreak assistance laboratory network in the Netherlands for the detection of the influenza virus A(H1N1) variant. |
{"1003": 0.13670019805431366, "1014": 0.25694093108177185, "1016": 0.6568518877029419, "1020": 0.04674193635582924, "1038": 0.5729197263717651, "1043": 0.2983669638633728, "2000": 0.10818854719400406, "2011": 0.09406650811433792, "2044": 0.2247048318386078, "2045": 0.10026945173740387, "2048": 0.12728634476661682, "205... | 10071552 | BACKGROUND Taxing sugar-sweetened beverages (SSBs) has been proposed in high-income countries to reduce obesity and type 2 diabetes. We sought to estimate the potential health effects of such a fiscal strategy in the middle-income country of India, where there is heterogeneity in SSB consumption, patterns of substituti... | Averting Obesity and Type 2 Diabetes in India through Sugar-Sweetened Beverage Taxation: An Economic-Epidemiologic Modeling Study |
{"1011": 0.10026945173740387, "2001": 0.009718249551951885, "2005": 0.20660123229026794, "2007": 0.38308101892471313, "2026": 0.9680526852607727, "2033": 0.18816383183002472, "2039": 0.10555581003427505, "2044": 0.5562619566917419, "2051": 0.04394211992621422, "2064": 0.3353555500507355, "2067": 0.036437395960092545, "... | 10071590 | We report a case of postvaccination acute myopericarditis in an adolescent. The patient presented with acute chest pain, diffuse ST-segment elevation, and elevated cardiac enzyme levels. Cardiac MRI was consistent with acute myocarditis. He recovered within a few days with nonsteroidal antiinflammatory treatment and re... | Acute myopericarditis after multiple vaccinations in an adolescent: case report and review of the literature. |
{"1014": 0.5244048833847046, "1040": 0.32129061222076416, "1044": 0.4437839686870575, "1052": 0.1619328260421753, "1054": 0.1677299439907074, "1055": 0.02412080205976963, "2002": 0.07068414986133575, "2006": 0.23710809648036957, "2035": 0.40220460295677185, "2058": 0.3423145115375519, "2062": 0.02792670577764511, "2080... | 10072941 | Epidemiological studies demonstrate that a lower blood pressure and decline in blood pressure over months or years are associated with higher mortality in dialysis patients. In contrast, randomized, controlled trials lack power to establish benefits of antihypertensive therapy. Patients on long-term dialysis participat... | Cardiovascular protection with antihypertensive drugs in dialysis patients: systematic review and meta-analysis. |
{"1017": 0.12814582884311676, "1043": 0.846739649772644, "1999": 0.01934296265244484, "2007": 0.5461324453353882, "2029": 0.0913962796330452, "2031": 0.007782140281051397, "2037": 0.0038986403960734606, "2050": 0.03831886500120163, "2058": 0.0058422754518687725, "2060": 0.04207121208310127, "2079": 0.27934664487838745,... | 10074251 | Protoplasmic astrocytes are increasingly thought to interact extensively with neuronal elements in the brain and to influence their activity. Recent reports have also begun to suggest that physiologically, and perhaps functionally, diverse forms of these cells may be present in the CNS. Our current understanding of ast... | Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. |
{"1003": 0.02412080205976963, "1006": 0.1011524572968483, "1009": 0.9546096324920654, "1011": 0.2089812457561493, "1039": 0.23247487843036652, "1042": 0.846739649772644, "1043": 0.5898461937904358, "1048": 0.052318159490823746, "2008": 0.17840765416622162, "2015": 0.6400018334388733, "2020": 0.034552380442619324, "2029... | 10078024 | Studies of the identity and physiological function of mesenchymal stromal cells (MSCs) have been hampered by a lack of markers that permit both prospective identification and fate mapping in vivo. We found that Leptin Receptor (LepR) is a marker that highly enriches bone marrow MSCs. Approximately 0.3% of bone marrow c... | Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. |
{"1006": 0.037378571927547455, "1014": 0.5307431221008301, "1016": 0.3423145115375519, "1041": 1.0326838493347168, "1049": 0.7809720039367676, "1052": 0.46363574266433716, "1055": 0.6064908504486084, "1996": 0.052318159490823746, "1997": 0.021256839856505394, "1999": 0.11256109178066254, "2004": 0.5074998140335083, "20... | 10086360 | Meiotic crossovers detected by pedigree analysis in the mouse MHC cluster into hotspots. To explore the properties of hotspots, we subjected the class II E(beta) gene to high-resolution sperm crossover analysis. We confirm the presence of a highly localized hotspot 1.0-1.6 kb wide in the second intron of E(beta) and sh... | High-resolution sperm typing of meiotic recombination in the mouse MHC Ebeta gene. |
{"1003": 0.11168810725212097, "1011": 0.026025565341114998, "1039": 0.16110190749168396, "1043": 0.3897167444229126, "1044": 0.10993985831737518, "1051": 0.029824240133166313, "1052": 0.5838727951049805, "1056": 0.5811457633972168, "1081": 0.7907629609107971, "1609": 0.3027053773403168, "2001": 0.012615402229130268, "2... | 10128893 | Allogeneic hematopoietic stem cell transplantation (HSCT) in thalassemia remains a challenge. We reported a single-centre case-control study of a large cohort of 516 children and adult patients treated with HSCT or blood transfusion support and iron chelation therapy; 258 patients (median age 12, range 1-45) underwent ... | Long-term survival of beta thalassemia major patients treated with hematopoietic stem cell transplantation compared with survival with conventional treatment. |
{"1040": 0.28963330388069153, "1047": 0.4891071021556854, "2001": 0.010684899985790253, "2008": 0.2026219218969345, "2011": 0.0913962796330452, "2013": 0.24859806895256042, "2020": 0.04953393340110779, "2029": 0.1332872211933136, "2030": 0.6338034868240356, "2054": 0.2317005842924118, "2060": 0.21293537318706512, "2078... | 10145528 | ATM, the gene that is mutated in ataxia-telangiectasia, is associated with cerebellar degeneration, abnormal proliferation of small blood vessels, and cancer. These clinically important manifestations have stimulated interest in defining the sequence variation in the ATM gene. Therefore, we undertook a comprehensive su... | Global analysis of ATM polymorphism reveals significant functional constraint. |
{"1006": 0.01934296265244484, "1009": 0.7701805830001831, "1016": 0.3339579105377197, "1037": 0.20818853378295898, "1049": 0.6664261221885681, "1056": 0.8608771562576294, "1998": 0.07341018319129944, "2005": 0.07159364968538284, "2015": 0.17431432008743286, "2029": 0.007782140281051397, "2035": 0.52266925573349, "2044"... | 10162553 | Immunosuppressive drugs and cytotoxic chemotherapy agents are designed to kill or suppress autoreactive, alloaggressive, or hyperinflammatory T cells, or disseminated malignancies. However, they also cause severe immunological side effects ranging from interrupted thymopoiesis and general immunodeficiency to, paradoxic... | Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment. |
{"1009": 0.1332872211933136, "1011": 0.3910386264324188, "1017": 0.7258110046386719, "1039": 0.3662964701652527, "1043": 0.24401791393756866, "1044": 0.04860413447022438, "1056": 0.6160298585891724, "2002": 0.06977381557226181, "2003": 0.020300358533859253, "2005": 0.1677299439907074, "2026": 0.5495203733444214, "2029"... | 10165258 | Maintaining hematopoietic stem cell (HSC) quiescence is a critical property for the life-long generation of blood cells. Approximately 75% of cells in a highly enriched long-term repopulating HSC (LT-HSC) pool (Lin(-)Sca1(+)c-Kit(hi)CD150(+)CD48(-)) are quiescent, with only a small percentage of the LT-HSCs in cycle. T... | GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. |
{"1011": 0.12814582884311676, "1017": 0.272677481174469, "1039": 0.17431432008743286, "1050": 0.03360854089260101, "1056": 0.42225050926208496, "1999": 0.06429435312747955, "2029": 0.06886265426874161, "2050": 0.2026219218969345, "2072": 0.39433568716049194, "2089": 0.20977331697940826, "2090": 0.04674193635582924, "21... | 10165723 | PURPOSE The CpG island methylator phenotype (CIMP) may be associated with development of malignancy through coordinated inactivation of tumor suppressor and tumor-related genes (TRG) and methylation of multiple noncoding, methylated-in-tumor (MINT) loci. These epigenetic changes create a distinct CIMP pattern that has ... | CpG island methylator phenotype predicts progression of malignant melanoma. |
{"1009": 0.13755162060260773, "1011": 0.272677481174469, "1015": 0.28082266449928284, "1019": 0.4145384132862091, "1043": 0.5596157908439636, "1045": 0.2105647772550583, "1048": 0.24171993136405945, "1052": 0.30558720231056213, "1999": 0.02412080205976963, "2005": 0.10818854719400406, "2010": 0.5232481360435486, "2011"... | 10169908 | PURPOSE We have previously identified solute-linked carrier family A1 member 5 (SLC1A5) as an overexpressed protein in a shotgun proteomic analysis of stage I non-small cell lung cancer (NSCLC) when compared with matched controls. We hypothesized that overexpression of SLC1A5 occurs to meet the metabolic demand for lun... | SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. |
{"1011": 0.5284429788589478, "1015": 0.07431721687316895, "1020": 0.15442965924739838, "1037": 0.5307431221008301, "1039": 0.20501139760017395, "1041": 0.49982786178588867, "1044": 0.18654440343379974, "1053": 0.5957841277122498, "1996": 0.030771657824516296, "1997": 0.09317722171545029, "1999": 0.06337817758321762, "2... | 10189634 | CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURP(Scm3), and Mis18 in vertebrates and fission yeast. The recruitment of Mis18 and HJURP(Scm3) to centromeres is cell cycle regulated. Vertebrate Mis18 associates wi... | Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly |
{"1011": 0.06977381557226181, "1014": 0.6338034868240356, "1039": 0.2317005842924118, "1045": 0.347847044467926, "1050": 0.28082266449928284, "1052": 0.5838727951049805, "1156": 0.5438674688339233, "2000": 0.319873183965683, "2005": 0.26446542143821716, "2007": 0.09672962874174118, "2020": 0.02887592278420925, "2044": ... | 10190462 | Background: Reduced brain insulin signaling and low CSF-to-plasma insulin ratios have been observed in patients with Alzheimer disease (AD). Furthermore, intracerebroventricular or IV insulin administration improve memory, alter evoked potentials, and modulate neurotransmitters, possibly by augmenting low brain levels.... | INTRANASAL INSULIN IMPROVES COGNITION AND MODULATES β-AMYLOID IN EARLY AD |
{"1009": 0.42926809191703796, "1011": 0.02887592278420925, "1042": 0.11168810725212097, "1048": 0.21922965347766876, "1056": 1.1230508089065552, "2008": 0.03360854089260101, "2011": 0.0174254160374403, "2012": 0.11604541540145874, "2029": 0.02887592278420925, "2037": 0.018384648486971855, "2043": 0.09761575609445572, "... | 10190778 | As the immune system develops, T cells are selected or regulated to become tolerant of self antigens and reactive against foreign antigens. In mice, the induction of such tolerance is thought to be attributable to the deletion of self-reactive cells. Here, we show that the human fetal immune system takes advantage of a... | Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. |
{"1011": 0.3106105625629425, "1015": 0.4673144817352295, "1020": 0.20102575421333313, "1037": 0.7258110046386719, "1038": 0.0058422754518687725, "1048": 0.6006163358688354, "1050": 0.5010119676589966, "1060": 0.5057345628738403, "1155": 0.0770333781838417, "1156": 0.9394577741622925, "2004": 0.058784693479537964, "2005... | 10207180 | INTRODUCTION The β-secretase enzyme, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), cleaves amyloid precursor protein (APP) in the first step in β-amyloid (Aβ) peptide production. Thus, BACE1 is a key target for candidate disease-modifying treatment of Alzheimer's disease. In a previous exploratory Aβ biom... | β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage |
{"1014": 0.2969166338443756, "1017": 0.28670501708984375, "1018": 0.0317181795835495, "1020": 0.45251765847206116, "1021": 0.2034190446138382, "1022": 0.14433705806732178, "1023": 0.2145126610994339, "1044": 0.3070250153541565, "1058": 0.5324648022651672, "1998": 0.0009760859538801014, "2001": 0.1011524572968483, "2003... | 10209731 | STUDY OBJECTIVE The aim of the study was to analyse differences in mortality from the main cardiovascular diseases (ischaemic heart disease, hypertensive disease, and cerebrovascular disease) among Chinese, Malays, and Indians in Singapore. DESIGN The study was a survey using national death registration data in Singapo... | Cardiovascular diseases in Chinese, Malays, and Indians in Singapore. I. Differences in mortality. |
{"1041": 0.3499138653278351, "1042": 0.14939609169960022, "2000": 0.11778303235769272, "2002": 0.058784693479537964, "2005": 0.19541899859905243, "2006": 0.012615402229130268, "2007": 0.03266380727291107, "2010": 0.7038320899009705, "2064": 0.3683255612850189, "2073": 0.29328158497810364, "2075": 0.004870930220931768, ... | 10212612 | A complete portrait of a cell requires a detailed description of its molecular topography: proteins must be linked to particular organelles. Immunocytochemical electron microscopy can reveal locations of proteins with nanometer resolution but is limited by the quality of fixation, the paucity of antibodies and the inac... | Protein localization in electron micrographs using fluorescence nanoscopy |
{"1014": 0.12038381397724152, "1038": 0.06795065850019455, "1039": 0.24171993136405945, "1042": 0.3381449282169342, "1043": 0.05786345899105072, "1052": 0.18167030811309814, "2003": 0.4158279001712799, "2005": 0.20102575421333313, "2011": 0.1734936386346817, "2029": 0.0606246218085289, "2039": 0.07341018319129944, "205... | 10218447 | Isorhamnetin is one member of flavonoid components which has been used in the treatment of heart disease. Recently the in vitro anti-cancer effect of isorhamnetin on human esophageal squamous carcinoma cell line Eca-109 was investigated in our lab. When Eca-109 cells were in vitro exposed to the graded doses of isorham... | The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. |
{"1009": 0.2674594223499298, "1011": 0.2696990668773651, "1020": 0.3499138653278351, "1041": 0.16442140936851501, "1044": 0.2689530849456787, "1999": 0.39762192964553833, "2007": 0.1710275560617447, "2011": 0.272677481174469, "2013": 0.09050461649894714, "2029": 0.3012613356113434, "2050": 0.37640097737312317, "2063": ... | 10247282 | In the rat isolated perfused kidney, arachidonic acid elicits cyclooxygenase-dependent vasoconstriction through activation of PGH2/TxA2 receptors; responses are enhanced in kidneys from diabetic rats. This study examined the roles of cyclooxygenase-1/cyclooxygenase-2 in the enhanced renal vasoconstrictor effect of arac... | Arachidonic Acid in the Diabetic Rat Kidney |
{"1011": 0.4412745535373688, "1044": 0.41065993905067444, "1052": 0.8534175157546997, "1997": 0.13243216276168823, "1999": 0.06520967930555344, "2000": 0.08782484382390976, "2002": 0.0038986403960734606, "2005": 0.10731173306703568, "2007": 0.7746911644935608, "2008": 0.1970241367816925, "2011": 0.030771657824516296, "... | 10247314 | There is evidence that hypoxia-inducible factor-1alpha (HIF-1alpha) interacts with the tumor suppressor p53. To characterize the putative interaction, we mapped the binding of the core domain of p53 (p53c) to an array of immobilized HIF-1alpha-derived peptides and found two peptide-sequence motifs that bound to p53c wi... | Two sequence motifs from HIF-1alpha bind to the DNA-binding site of p53. |
{"2005": 0.12986256182193756, "2015": 0.6773988008499146, "2020": 0.11691460013389587, "2029": 0.26820653676986694, "2093": 0.2447827309370041, "2109": 0.1734936386346817, "2116": 0.4673144817352295, "2135": 0.3897167444229126, "2193": 0.3297532796859741, "2220": 0.39762192964553833, "2229": 0.3027053773403168, "2240":... | 10273147 | Human induced pluripotent stem cells (iPSCs) present exciting opportunities for studying development and for in vitro disease modeling. However, reported variability in the behavior of iPSCs has called their utility into question. We established a test set of 16 iPSC lines from seven individuals of varying age, sex and... | A functionally characterized test set of human induced pluripotent stem cells |
{"1011": 0.4450363218784332, "1016": 0.8981585502624512, "1046": 0.75193190574646, "1047": 0.4818955361843109, "1048": 0.02792670577764511, "1049": 0.1602703034877777, "1052": 0.11778303235769272, "1055": 0.5174443125724792, "2003": 0.1889725625514984, "2008": 0.13157635927200317, "2025": 0.08064348995685577, "2029": 0... | 10279084 | MAP kinase phosphatase-2 (MKP-2) is a member of the family of dual specificity phosphatases that functions to inactivate the ERK and JNK MAP kinase signalling pathways. Here, we identify a novel human MKP-2 variant (MKP-2-S) lacking the MAP kinase binding site but retaining the phosphatase catalytic domain. Endogenous ... | Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2. |
{"1017": 0.28963330388069153, "1042": 0.0913962796330452, "1051": 0.11778303235769272, "1999": 0.02412080205976963, "2004": 0.09228714555501938, "2005": 0.05046287178993225, "2007": 0.26296505331993103, "2011": 0.28155985474586487, "2012": 0.6659244894981384, "2026": 0.7067264318466187, "2029": 0.18004031479358673, "20... | 10284593 | Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation. However, whether inflammation is the cause or the consequence of atrial fibrillation and which specific inflammatory mediators may increase the atria's susceptibility to fibrillation remain elu... | Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation |
{"1003": 0.02412080205976963, "1018": 0.43623676896095276, "1043": 0.0770333781838417, "1050": 0.5393219590187073, "1052": 0.0797421783208847, "1997": 0.12470348179340363, "1998": 0.34508460760116577, "2000": 0.07431721687316895, "2001": 0.3241194784641266, "2004": 0.35060185194015503, "2006": 0.3601844012737274, "2007... | 10300000 | The results of a survey of 769 patients attending the St. James's University Fertility Control Clinic, England, for abortion services showed that patients seeing general practitioners were less knowledgeable than those attending specialist clinics. There was a demonstrated need for counseling on pill and condom use and... | Knowledge and use of secondary contraception among patients requesting termination of pregnancy. |
{"1019": 0.13755162060260773, "2013": 0.6989894509315491, "2015": 0.28743788599967957, "2020": 0.08603433519601822, "2024": 0.02412080205976963, "2031": 0.03266380727291107, "2038": 0.10993985831737518, "2042": 0.1221139207482338, "2045": 0.004870930220931768, "2064": 0.04207121208310127, "2073": 0.2184450328350067, "2... | 10300888 | Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection and where the plethora of industrial strains originates from. Here, we present the genomes and phenomes of 157 industrial Sacchar... | Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts |
{"1037": 0.004870930220931768, "2001": 0.15943801403045654, "2008": 0.0842406153678894, "2011": 0.13925230503082275, "2015": 0.1930064558982849, "2024": 0.03925827145576477, "2029": 0.02316705882549286, "2043": 0.10993985831737518, "2072": 0.495672345161438, "2097": 0.3381449282169342, "2106": 0.2089812457561493, "2111... | 10314816 | Until the 1990s, Amblyomma americanum was regarded primarily as a nuisance species, but a tick of minor importance as a vector of zoonotic pathogens affecting humans. With the recent discoveries of Ehrlichia chaffeensis, Ehrlichia ewingii, and "Borrelia lonestari," the public health relevance of lone star ticks is no l... | The ascendancy of Amblyomma americanum as a vector of pathogens affecting humans in the United States. |
{"1011": 0.2800849378108978, "1016": 0.3750596046447754, "1038": 0.04394211992621422, "1040": 0.49626702070236206, "1042": 0.29400965571403503, "1050": 0.4248080551624298, "2019": 0.6275664567947388, "2029": 0.3381449282169342, "2036": 0.42735910415649414, "2048": 0.025073638185858727, "2072": 0.4831010699272156, "2078... | 10326242 | PALB2 was recently identified as a nuclear binding partner of BRCA2. Biallelic BRCA2 mutations cause Fanconi anemia subtype FA-D1 and predispose to childhood malignancies. We identified pathogenic mutations in PALB2 (also known as FANCN) in seven families affected with Fanconi anemia and cancer in early childhood, demo... | Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer |
{"1038": 0.6165571808815002, "1041": 0.25694093108177185, "1052": 0.21765978634357452, "1997": 0.1905880719423294, "2001": 0.009718249551951885, "2011": 0.053244512528181076, "2013": 0.2493593990802765, "2029": 0.025073638185858727, "2038": 0.09761575609445572, "2042": 0.16359257698059082, "2046": 0.319873183965683, "2... | 10335603 | A cloned 340-bp DNA fragment excised by EcoRI from the Chironomus pallividittatus genome has been localized to the telomeres by in situ hybridization as well as to connectives between telomeres. No hybridization was observed in other regions of the chromosomes. Another cloned EcoRI fragment, 525 bp long has also been s... | Long tandem arrays of complex repeat units in Chironomus telomeres. |
{"1006": 0.21372433006763458, "1009": 0.6348392367362976, "1011": 0.11951763927936554, "1015": 0.14518201351165771, "1017": 0.055094651877880096, "1018": 0.1873544454574585, "1019": 0.1970241367816925, "1020": 0.026976587250828743, "1058": 0.6862877607345581, "1996": 0.3353555500507355, "1997": 0.12728634476661682, "19... | 10342807 | BACKGROUND The electrical activity of the atrioventricular node (AVN) is functionally heterogeneous, but how this relates to distinct cell types and the 3-dimensional structure of the AVN is unknown. To address this, we have studied the expression of Na(V)1.5 and other Na+ channel isoforms in the AVN. METHODS AND RESUL... | Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat. |
{"1038": 1.2181298732757568, "1042": 1.1506214141845703, "1047": 0.8583967685699463, "1049": 1.0312920808792114, "1056": 0.22626367211341858, "1062": 0.1718502640724182, "1996": 0.31132611632347107, "1998": 0.1221139207482338, "2008": 0.03266380727291107, "2011": 0.31845372915267944, "2029": 0.29109421372413635, "2033"... | 10354110 | Follicular (FO) and marginal zone (MZ) B cells are maintained in distinct locations within the spleen, but the genetic basis for this separation is still enigmatic. We now report that B cell sequestration requires lineage-specific regulation of migratory receptors by the transcription factor Klf2. Moreover, using gene-... | Follicular B cell trafficking within the spleen actively restricts humoral immune responses. |
{"1009": 0.36086538434028625, "1011": 0.33675122261047363, "1015": 0.11168810725212097, "1016": 0.5086748600006104, "1021": 0.21765978634357452, "1038": 0.347847044467926, "1041": 0.7969439625740051, "1047": 0.5162794589996338, "1048": 0.4709797203540802, "1056": 0.7546905279159546, "1998": 0.3070250153541565, "2007": ... | 10359591 | Interleukin(IL)-2 and inflammation regulate effector and memory cytolytic T-lymphocyte (CTL) generation during infection. We demonstrate a complex interplay between IL-2 and inflammatory signals during CTL differentiation. IL-2 stimulation induced the transcription factor eomesodermin (Eomes), upregulated perforin (Prf... | Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. |
{"1038": 0.10291612148284912, "1040": 0.06886265426874161, "1047": 0.015504186972975731, "1997": 0.006812678650021553, "2007": 0.13670019805431366, "2013": 0.08692999184131622, "2020": 0.058784693479537964, "2038": 0.2607102394104004, "2042": 0.43244171142578125, "2073": 0.32764431834220886, "2088": 0.02316705882549286... | 10365749 | BACKGROUND Tuberculosis (TB) has been reported to be associated with poverty, especially in developing countries. Hong Kong is one of the few industrialised areas with a high incidence of TB where previous reports on the effect of poverty at neighbourhood level have been conflicting. OBJECTIVE To examine the spatial di... | Neighbourhood risk factors for tuberculosis in Hong Kong. |
{"1011": 0.09584271162748337, "1013": 0.4709797203540802, "1015": 0.17759032547473907, "1039": 0.6588751673698425, "1041": 0.2822965085506439, "1043": 0.23402166366577148, "1057": 0.6223390698432922, "1996": 0.19622190296649933, "2003": 0.2105647772550583, "2007": 0.022212404757738113, "2008": 0.16524957120418549, "201... | 10365787 | The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein ligase that, together with Cdc20 or Cdh1, targets cell-cycle proteins for degradation. APC/C–Cdh1 specifically promotes protein degradation in late mitosis and G1. Mutant embryos lacking Cdh1 die at E9.5–E10.5 due to defects in the endoreduplica... | Genomic stability and tumour suppression by the APC/C cofactor Cdh1 |
{"1003": 0.014542185701429844, "1017": 0.012615402229130268, "1018": 0.0842406153678894, "1019": 0.12814582884311676, "1021": 0.022212404757738113, "1022": 0.07612881064414978, "1023": 0.021256839856505394, "1037": 0.08244366943836212, "1997": 0.12642613053321838, "2000": 0.2576959431171417, "2005": 0.01454218570142984... | 10374686 | Although 65% of people with cancer want to die at home, only about 30% are successful in doing so.1,2 A government committed to choice for patients must improve this figure.3 Developing palliative care services in primary care is essential for realising the expectations of dying people. Such services could also offer i... | Developing primary palliative care. |
{"1003": 0.3560888469219208, "1014": 0.31132611632347107, "1041": 0.34922540187835693, "1052": 0.10291612148284912, "2000": 0.02316705882549286, "2001": 0.07159364968538284, "2005": 0.0752234235405922, "2012": 0.26820653676986694, "2020": 0.15693697333335876, "2022": 0.22079704701900482, "2025": 0.014542185701429844, "... | 10408324 | BACKGROUND Emergency postcoital contraception prevents pregnancy, but it must be prescribed by a doctor and taken within 72 hours of intercourse. It has been proposed that emergency contraception be made available without a prescription. We undertook a study to learn how women might behave if given a supply of emergenc... | The effects of self-administering emergency contraception. |
{"1011": 0.32129061222076416, "1022": 0.4794800877571106, "1038": 0.5410289764404297, "1047": 0.6181373596191406, "1050": 0.07068414986133575, "1054": 0.3982778787612915, "1055": 0.5573811531066895, "1057": 0.3560888469219208, "1997": 0.0606246218085289, "1999": 0.0606246218085289, "2003": 0.11430477350950241, "2004": ... | 10423989 | The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD). SRm160 contains multiple SR repeats, but unlike proteins of the SR family of splicing factors... | A coactivator of pre-mRNA splicing. |
{"1003": 0.05970508232712746, "1014": 0.36967599391937256, "1016": 0.5244048833847046, "1042": 0.0770333781838417, "1043": 0.6714286804199219, "1044": 0.2561853528022766, "1052": 0.5584990978240967, "2001": 0.0009760859538801014, "2005": 0.36290550231933594, "2007": 0.21687394380569458, "2012": 0.6902132034301758, "202... | 10430148 | CONTEXT No antidiabetic regimen has demonstrated the ability to reduce progression of coronary atherosclerosis. Commonly used oral glucose-lowering agents include sulfonylureas, which are insulin secretagogues, and thiazolidinediones, which are insulin sensitizers. OBJECTIVE To compare the effects of an insulin sensiti... | Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial. |
{"1011": 0.13670019805431366, "1017": 0.4374985992908478, "1041": 0.0354953333735466, "1052": 0.1677299439907074, "1053": 0.04860413447022438, "1055": 0.30917787551879883, "2003": 0.3897167444229126, "2008": 0.16607704758644104, "2011": 0.259204238653183, "2015": 0.0913962796330452, "2029": 0.35745587944984436, "2072":... | 10443642 | RNAIII is the intracellular effector of the quorum-sensing system in Staphylococcus aureus. It is one of the largest regulatory RNAs (514 nucleotides long) that are known to control the expression of a large number of virulence genes. Here, we show that the 3' domain of RNAIII coordinately represses at the post-transcr... | Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. |
{"1011": 0.38374659419059753, "1018": 0.17267228662967682, "1022": 0.11865071207284927, "1044": 0.36494144797325134, "1048": 0.5909284353256226, "1049": 0.30989447236061096, "1056": 0.8450632095336914, "1999": 0.004870930220931768, "2002": 0.07612881064414978, "2003": 0.29981520771980286, "2011": 0.3019835948944092, "2... | 10450300 | Human cytomegalovirus (HCMV) is a widely prevalent human herpesvirus, which, after primary infection, persists in the host for life. In healthy individuals, the virus is well controlled by the HCMV-specific T cell response. A key feature of this persistence, in the face of a normally robust host immune response, is the... | Human Cytomegalovirus Latency-Associated Proteins Elicit Immune-Suppressive IL-10 Producing CD4+ T Cells |
{"1011": 0.0354953333735466, "1019": 0.012615402229130268, "1054": 0.7674643993377686, "1999": 0.03360854089260101, "2002": 0.7305257320404053, "2005": 0.2105647772550583, "2007": 0.053244512528181076, "2010": 0.28082266449928284, "2011": 0.08871890604496002, "2029": 0.14433705806732178, "2033": 0.6275664567947388, "20... | 10450725 | BACKGROUND/AIMS The small GTPase of Ras and Rho families are widely involved in human tumorgenesis and metastasis. It has recently been reported that pamidronate inhibits the mevalonate pathway, which is required for the prenylation of the small GTPase. We demonstrated a possible beneficial use of pamidronate in the tr... | Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma. |
{"1020": 0.1212492436170578, "2003": 0.28963330388069153, "2012": 0.1808556467294693, "2020": 0.07068414986133575, "2058": 0.5871354341506958, "2076": 0.2674594223499298, "2079": 0.11604541540145874, "2112": 0.0770333781838417, "2117": 0.21922965347766876, "2135": 0.08244366943836212, "2146": 0.07793712615966797, "2206... | 10463997 | Objectives: Autophagy is a highly regulated process that has an important role in the control of a wide range of cellular functions, such as organelle recycling, nutrient availability and tissue differentiation. A recent study has shown an increased autophagic activity in the adipose tissue of obese subjects, and a rol... | Defective regulation of adipose tissue autophagy in obesity |
{"1016": 0.0770333781838417, "1039": 0.1718502640724182, "1043": 0.0174254160374403, "1056": 0.23247487843036652, "2008": 0.016465263441205025, "2011": 0.17020416259765625, "2029": 0.16442140936851501, "2043": 0.014542185701429844, "2044": 0.6441128253936768, "2064": 0.055094651877880096, "2067": 0.08154398202896118, "... | 10474873 | Failure of axons of the central nervous system in adult mammals to regenerate spontaneously after injury is attributed in part to inhibitory molecules associated with oligodendrocytes. Regeneration of central nervous system axons in fish is correlated with the presence of a transglutaminase. This enzyme dimerizes inter... | Recovery of visual response of injured adult rat optic nerves treated with transglutaminase. |
{"1043": 0.29981520771980286, "1048": 0.20102575421333313, "1156": 0.8022117614746094, "1999": 0.0029254043474793434, "2002": 0.7380234599113464, "2011": 0.36967599391937256, "2029": 0.22392450273036957, "2038": 0.0317181795835495, "2050": 0.05139094591140747, "2076": 0.46853771805763245, "2079": 0.04860413447022438, "... | 10482574 | Cells exposed to stress of different origins synthesize triacylglycerols and generate lipid droplets (LD), but the physiological relevance of this response is uncertain. Using complete nutrient deprivation of cells in culture as a simple model of stress, we have addressed whether LD biogenesis has a protective role in ... | Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids. |
{"1018": 0.4437839686870575, "1039": 0.09050461649894714, "1041": 0.736154317855835, "1050": 0.5651806592941284, "1052": 0.5174443125724792, "1053": 0.4412745535373688, "2003": 0.11256109178066254, "2011": 0.10291612148284912, "2020": 0.014542185701429844, "2029": 0.055094651877880096, "2039": 0.3325583338737488, "2050... | 10485142 | Nasopharyngeal carcinoma (NPC) is a common disease in Hong Kong and southern provinces of China. EBV infection is believed to play a critical role in the development of NPC. Previous studies on the transformation mechanism of EBV genes were mostly performed in either NPC or nonnasopharyngeal epithelial cells which may ... | Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase. |
{"1011": 0.3519764244556427, "1038": 0.29400965571403503, "1040": 0.14602625370025635, "1043": 0.4950772523880005, "1044": 0.21765978634357452, "1047": 0.8764448165893555, "1056": 0.27564704418182373, "2004": 0.02316705882549286, "2005": 0.026025565341114998, "2007": 0.2317005842924118, "2011": 0.0770333781838417, "202... | 10486817 | BACKGROUND Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases by controlling cell proliferation and survival to mediate neural crest expansion. CNBP has been found to bi... | Cellular nucleic acid binding protein suppresses tumor cell metastasis and induces tumor cell death by downregulating heterogeneous ribonucleoprotein K in fibrosarcoma cells. |
{"1055": 0.6679295301437378, "1060": 1.094698429107666, "2011": 0.3777405619621277, "2015": 0.11604541540145874, "2029": 0.07793712615966797, "2030": 0.417115718126297, "2038": 0.009718249551951885, "2042": 0.02316705882549286, "2076": 0.11604541540145874, "2079": 0.13499516248703003, "2099": 0.6970458030700684, "2102"... | 10491220 | Exposure to xenobiotics such as plant toxins, pollutants, or prescription drugs triggers a defense response, inducing genes that encode key detoxification enzymes. Although xenobiotic responses have been studied in vertebrates, little effort has been made to exploit a simple genetic system for characterizing the molecu... | The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila. |
{"1052": 0.46608972549438477, "1997": 0.15023678541183472, "1998": 0.1994270235300064, "2006": 0.500420093536377, "2011": 0.4794800877571106, "2029": 0.015504186972975731, "2057": 0.12384103983640671, "2063": 0.1011524572968483, "2064": 0.35745587944984436, "2071": 0.10467668622732162, "2076": 0.11430477350950241, "207... | 10494012 | Amodel that explains both the origin and sporadic nature of cancer argues that cancer cells are a chance result of events that cause genomic and epigenetic variability. The prevailing view is that these events are mutations that affect chromosome segregation or stability. However, genomic and epigenetic variability is ... | A primate virus generates transformed human cells by fusion |
{"1022": 0.2954642176628113, "1041": 0.32553088665008545, "1052": 0.2786078155040741, "1998": 0.007782140281051397, "2008": 0.016465263441205025, "2015": 0.0354953333735466, "2029": 0.2145126610994339, "2037": 0.0029254043474793434, "2076": 0.14349138736724854, "2079": 0.10906458646059036, "2090": 0.43244171142578125, ... | 10504681 | Plants have evolved a tremendous ability to respond to environmental changes by adapting their growth and development. The interaction between hormonal and developmental signals is a critical mechanism in the generation of this enormous plasticity. A good example is the response to the hormone ethylene that depends on ... | TAA1-Mediated Auxin Biosynthesis Is Essential for Hormone Crosstalk and Plant Development |
{"1044": 0.22859740257263184, "1052": 0.7683706283569336, "1054": 0.21372433006763458, "2001": 0.0009760859538801014, "2003": 0.14518201351165771, "2038": 0.1401015669107437, "2042": 0.25845035910606384, "2043": 0.11081436276435852, "2054": 0.2026219218969345, "2079": 0.0174254160374403, "2099": 0.16276304423809052, "2... | 10509344 | In the past decades, public health research has focused on categorical rather than cross-cutting or systems issues. Little research has been carried out on the infrastructure required to support public health programs. This article describes the results of an interactive process to develop a research agenda for public ... | A research agenda for public health workforce development. |
{"1052": 0.06154331564903259, "1996": 0.5209306478500366, "2003": 0.12470348179340363, "2029": 0.08692999184131622, "2034": 0.5979346632957458, "2043": 0.13157635927200317, "2046": 0.036437395960092545, "2048": 0.20660123229026794, "2054": 0.36900100111961365, "2057": 0.2969166338443756, "2073": 0.21687394380569458, "2... | 10518721 | Our eyes send different 'images' of the outside world to the brain — an image of contours (line drawing), a colour image (watercolour painting) or an image of moving objects (movie). This is commonly referred to as parallel processing, and starts as early as the first synapse of the retina, the cone pedicle. Here, the ... | Parallel processing in the mammalian retina |
{"1004": 0.0317181795835495, "1011": 0.09406650811433792, "1016": 0.14095009863376617, "1042": 0.5045560002326965, "1051": 0.3916989266872406, "1998": 0.996573805809021, "2005": 0.48850810527801514, "2015": 0.1734936386346817, "2019": 0.5393219590187073, "2020": 0.02316705882549286, "2029": 0.1358480453491211, "2072": ... | 10526279 | Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains incompletely understood. Aged Fancd2(-/-) mice were used to assess the therapeutic efficacy of oxymetholone (OXM) and its mechanism of action. Eighteen-month-old Fancd2(-/-) mice re... | Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling |
{"1015": 0.09761575609445572, "1016": 0.07884006202220917, "1017": 0.40741631388664246, "1048": 0.38041436672210693, "2001": 0.08782484382390976, "2020": 0.1718502640724182, "2033": 0.1994270235300064, "2048": 0.6921701431274414, "2093": 0.1064341589808464, "2094": 0.16359257698059082, "2102": 0.25995752215385437, "210... | 10530014 | Monogenic deficiency diseases provide unique opportunities to define the contributions of individual molecules to human physiology and to identify pathologies arising from their dysfunction. Here we describe a deficiency disease in two human siblings that presented with severe bleeding, frequent infections and osteopet... | A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans |
{"1039": 0.08154398202896118, "1042": 0.40285754203796387, "1043": 0.6369074583053589, "1052": 0.15693697333335876, "2006": 0.0797421783208847, "2011": 0.34370049834251404, "2015": 0.12814582884311676, "2029": 0.33953672647476196, "2031": 0.040196798741817474, "2050": 0.0058422754518687725, "2075": 0.6327666640281677, ... | 10534299 | AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input in controlling these neurons is unknown. To address this question, we generated mice lacking NMDA receptors (NMDARs) on either AgRP or POMC neurons. Deletion of ... | Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone |
{"1998": 0.04860413447022438, "1999": 0.06703783571720123, "2025": 0.08064348995685577, "2045": 0.0606246218085289, "2053": 0.1064341589808464, "2064": 0.013579257763922215, "2073": 0.4425300657749176, "2078": 0.5404602885246277, "2111": 0.28155985474586487, "2124": 0.009718249551951885, "2148": 0.822151780128479, "215... | 10536636 | Background Blindness and low vision are thought to be common in southern Sudan. However, the magnitude and geographical distribution are largely unknown. We aimed to estimate the prevalence of blindness and low vision, identify the main causes of blindness and low vision, and estimate targets for blindness prevention p... | Prevalence and Causes of Blindness and Low Vision in Southern Sudan |
{"1014": 0.34715715050697327, "1041": 0.848413348197937, "1050": 0.18492233753204346, "1052": 0.21765978634357452, "1998": 0.4126010537147522, "1999": 0.3784096837043762, "2007": 0.1064341589808464, "2011": 0.2409527748823166, "2012": 0.20580662786960602, "2013": 0.058784693479537964, "2020": 0.09228714555501938, "2025... | 10538985 | BACKGROUND Raised concentrations of nitrate and nitrite have been found in exhaled breath condensate (EBC) in airway disease, and it has been postulated that this reflects increased nitric oxide (NO) metabolism. However, the chemical and anatomical origin of nitrate and nitrite in the airways has not yet been sufficien... | Origin of nitrite and nitrate in nasal and exhaled breath condensate and relation to nitric oxide formation. |
{"1015": 0.151916041970253, "1017": 0.1946154683828354, "1048": 0.3005385100841522, "2003": 0.26820653676986694, "2004": 1.274838924407959, "2005": 0.029824240133166313, "2038": 0.0029254043474793434, "2046": 0.0842406153678894, "2054": 0.011650617234408855, "2064": 0.2105647772550583, "2080": 1.1653456687927246, "2094... | 10542877 | Next-generation sequencing technologies have greatly expanded our understanding of cancer genetics. Antisense technology is an attractive platform with the potential to translate these advances into improved cancer therapeutics, because antisense oligonucleotide (ASO) inhibitors can be designed on the basis of gene seq... | AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer |
{"1011": 0.4145384132862091, "1015": 0.45251765847206116, "1041": 0.03360854089260101, "1055": 0.304147332906723, "2002": 0.8143964409828186, "2003": 0.08961215615272522, "2005": 0.04953393340110779, "2008": 0.05694137513637543, "2013": 0.41065993905067444, "2015": 0.4494072198867798, "2020": 0.2231435477733612, "2028"... | 10546779 | Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst. The SCNT-hES-1 cells displayed typical ES cell morphology and ... | Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. |
{"1011": 0.1510767638683319, "1016": 0.36697331070899963, "1017": 0.0174254160374403, "1018": 0.5461324453353882, "1020": 0.19381128251552582, "1052": 0.04207121208310127, "1997": 0.06612417846918106, "2003": 0.014542185701429844, "2008": 0.05970508232712746, "2029": 0.2852376699447632, "2035": 0.09850110858678818, "20... | 10548391 | The enzyme debrisoquine 4-hydroxylase (CYP2D6), which metabolizes many widely used drugs, is highly polymorphic. The activity of the enzyme ranges between subjects from ultrafast to a complete absence. Therefore, metabolic capacity varies, producing intersubject differences in therapeutic efficacy and side effects at s... | Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication. |
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