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{"1009": 0.9340999722480774, "1011": 0.04860413447022438, "1016": 0.3923587501049042, "1043": 0.26146242022514343, "1050": 0.013579257763922215, "1062": 1.262204885482788, "1996": 0.15275461971759796, "1999": 0.3956514894962311, "2005": 0.012615402229130268, "2007": 0.23710809648036957, "2008": 0.17431432008743286, "20... | 10555591 | Zn2+ is present at high concentrations in the synaptic vesicles of hippocampal mossy fibers. We have used Zn2+ chelators and the mocha mutant mouse to address the physiological role of Zn2+ in this pathway. Zn2+ is not involved in the unique presynaptic plasticities observed at mossy fiber synapses but is coreleased wi... | The Actions of Synaptically Released Zinc at Hippocampal Mossy Fiber Synapses |
{"1011": 0.04113444685935974, "1014": 0.34300774335861206, "1019": 0.08603433519601822, "1026": 0.2223619967699051, "1042": 0.8091925978660583, "1052": 0.861702561378479, "1997": 0.04394211992621422, "1998": 0.009718249551951885, "1999": 0.03925827145576477, "2001": 0.0009760859538801014, "2002": 0.37035053968429565, "... | 10557471 | The aim of the present investigation was to study the effect of a dietary intervention which combined nutrition information with increased availability of vegetables, fruits and wholegrain bread. The effect of the intervention was determined by changes in the intake of vegetables, fruits, wholegrain bread and estimated... | Association between folate intake from different food sources in Norway and homocysteine status in a dietary intervention among young male adults. |
{"1006": 0.06977381557226181, "1009": 0.5393219590187073, "1011": 0.3443928062915802, "1013": 0.15943801403045654, "1015": 0.2674594223499298, "1045": 0.5551415085792542, "1056": 0.6916812658309937, "1059": 0.7201237678527832, "1155": 0.5914691090583801, "1156": 0.7746911644935608, "2007": 0.2531573474407196, "2011": 0... | 10559501 | Studies with mice lacking the common plasma membrane receptor for type I interferon (IFN-αβR(-)(/)(-)) have revealed that IFN signaling restricts tropism, dissemination, and lethality after infection with West Nile virus (WNV) or several other pathogenic viruses. However, the specific functions of individual IFN subtyp... | Beta interferon controls West Nile virus infection and pathogenesis in mice. |
{"1009": 0.9944084882736206, "1016": 0.18167030811309814, "1039": 0.29328158497810364, "1056": 1.0587663650512695, "1997": 0.14264501631259918, "1999": 0.02316705882549286, "2005": 0.2607102394104004, "2006": 0.2561853528022766, "2020": 0.0913962796330452, "2029": 0.1064341589808464, "2034": 0.19381128251552582, "2043"... | 10562341 | The activation of T cells is the fundamental on switch for the adaptive immune system. Ca2+ signaling is essential for T cell activation and starts as initial, short-lived, localized Ca2+ signals. The second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) forms rapidly upon T cell activation and stimula... | Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor |
{"1011": 0.15860503911972046, "1016": 0.3409265875816345, "1020": 0.2983669638633728, "1041": 0.2034190446138382, "1043": 0.6634125709533691, "1051": 0.12814582884311676, "1054": 0.7144040465354919, "1156": 0.9635916948318481, "2003": 0.11604541540145874, "2011": 0.574020504951477, "2012": 0.012615402229130268, "2029":... | 10574949 | Laminin β2 is a component of laminin-521, which is an important constituent of the glomerular basement membrane (GBM). Null mutations in laminin β2 (LAMB2) cause Pierson syndrome, a severe congenital nephrotic syndrome with ocular and neurologic defects. In contrast, patients with LAMB2 missense mutations, such as R246... | A missense LAMB2 mutation causes congenital nephrotic syndrome by impairing laminin secretion. |
{"1011": 0.5734702348709106, "1015": 0.2531573474407196, "1016": 0.3381449282169342, "1017": 0.2531573474407196, "1055": 0.10379679501056671, "1164": 0.29328158497810364, "1999": 0.3012613356113434, "2011": 0.2674594223499298, "2026": 0.4041621685028076, "2029": 0.2667117714881897, "2043": 0.007782140281051397, "2044":... | 10576136 | BACKGROUND ST2 is an interleukin (IL)-1 receptor family member with membrane-bound (ST2L) and soluble (sST2) isoforms, and sST2 is a biomarker for poor outcome in patients with myocardial infarction (MI). IL-33, the recently discovered ligand for ST2, activates nuclear factor kappaB and thus may regulate apoptotic cell... | Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. |
{"1014": 0.7038320899009705, "1044": 0.3777405619621277, "1052": 0.6813592314720154, "1062": 1.039613962173462, "2000": 0.08064348995685577, "2001": 0.3381449282169342, "2020": 0.1751343309879303, "2042": 0.151916041970253, "2043": 0.38041436672210693, "2051": 0.32129061222076416, "2062": 0.3318578004837036, "2084": 0.... | 10577574 | BACKGROUND In the year 2000, the organizational structure of the ICU in the Zaandam Medical Centre (ZMC) changed from an open to a closed format ICU. The objective of this study was to evaluate the effect of this organizational change on outcome in high risk surgical patients. METHODS The medical records of all consecu... | The impact of open versus closed format ICU admission practices on the outcome of high risk surgical patients: a cohort analysis |
{"1011": 0.06612417846918106, "1014": 0.055094651877880096, "1020": 0.4487839937210083, "1041": 0.6634125709533691, "1043": 0.5104349255561829, "1052": 0.11430477350950241, "2007": 0.2089812457561493, "2015": 0.5057345628738403, "2029": 0.06795065850019455, "2033": 0.6471850275993347, "2034": 0.1970241367816925, "2044"... | 10582939 | CONTEXT Antibody-based induction therapy plus calcineurin inhibitors (CNIs) reduce acute rejection rates in kidney recipients; however, opportunistic infections and toxic CNI effects remain challenging. Reportedly, mesenchymal stem cells (MSCs) have successfully treated graft-vs-host disease. OBJECTIVE To assess autolo... | Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial. |
{"1011": 0.0317181795835495, "1052": 1.1109062433242798, "1996": 0.5718178153038025, "1998": 0.11343330889940262, "2005": 0.06612417846918106, "2015": 0.19381128251552582, "2024": 0.09050461649894714, "2029": 0.272677481174469, "2046": 0.1693800985813141, "2048": 0.030771657824516296, "2054": 0.11343330889940262, "2073... | 10605189 | The mammalian cerebral cortex is responsible for the highest levels of associative, cognitive and motor functions. In the central nervous system (CNS) the cortex stands as a prime example of extreme neuronal diversity, broadly classified into excitatory projection neurons (PNs) and inhibitory interneurons (INs). We rev... | Cerebral cortex assembly: generating and reprogramming projection neuron diversity |
{"1011": 0.3248254358768463, "1041": 0.06612417846918106, "1048": 1.0464962720870972, "1056": 0.5347557663917542, "1998": 0.31204116344451904, "2011": 0.083342544734478, "2012": 0.10731173306703568, "2015": 0.0029254043474793434, "2033": 0.4950772523880005, "2037": 0.0317181795835495, "2038": 0.02887592278420925, "2042... | 10607877 | Cell surface receptors have been extensively studied because they initiate and regulate signal transduction cascades leading to a variety of functional cellular outcomes. An important class of immune receptors (e.g., T-cell antigen receptors) whose ligands are anchored to the surfaces of other cells remain poorly under... | Mechanical modulation of receptor-ligand interactions at cell-cell interfaces. |
{"1011": 0.11343330889940262, "1014": 0.36290550231933594, "1017": 0.5618454217910767, "1018": 0.10906458646059036, "1020": 0.27712854743003845, "1021": 0.5220900774002075, "1055": 0.02887592278420925, "1997": 0.0009760859538801014, "2007": 0.38308101892471313, "2019": 0.2576959431171417, "2020": 0.025073638185858727, ... | 10608397 | BACKGROUND Paralysis or amputation of an arm results in the loss of the ability to orient the hand and grasp, manipulate, and carry objects, functions that are essential for activities of daily living. Brain-machine interfaces could provide a solution to restoring many of these lost functions. We therefore tested wheth... | High-performance neuroprosthetic control by an individual with tetraplegia. |
{"1040": 0.11256109178066254, "1997": 0.01934296265244484, "1998": 0.37102460861206055, "2007": 0.10818854719400406, "2011": 0.24018502235412598, "2012": 0.176772341132164, "2028": 0.009718249551951885, "2029": 0.04394211992621422, "2033": 0.503966212272644, "2048": 0.07793712615966797, "2051": 0.5045560002326965, "206... | 10608822 | Daily synchronous rhythms of cell division at the tissue or organism level are observed in many species and suggest that the circadian clock and cell cycle oscillators are coupled. For mammals, despite known mechanistic interactions, the effect of such coupling on clock and cell cycle progression, and hence its biologi... | Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle. |
{"1037": 0.42735910415649414, "1052": 0.6999598741531372, "1053": 0.9724938273429871, "2004": 0.757441520690918, "2005": 0.22782009840011597, "2007": 0.09672962874174118, "2011": 0.23015019297599792, "2029": 0.18329764902591705, "2043": 0.009718249551951885, "2044": 0.4574742913246155, "2063": 0.07159364968538284, "206... | 10617916 | Background. Artemisinin-based combination therapy (ACT) reduces microscopically confirmed gametocytemia and mosquito infection. However, molecular techniques have recently revealed high prevalences of submicroscopic gametocytemia. Our objective here was to determine the effect of sulfadoxine-pyrimethamine (SP) monother... | Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum. |
{"1011": 0.1873544454574585, "1996": 0.0058422754518687725, "1998": 0.1994270235300064, "2005": 0.06703783571720123, "2007": 0.1064341589808464, "2029": 0.034552380442619324, "2034": 0.1734936386346817, "2064": 0.007782140281051397, "2075": 0.029824240133166313, "2076": 0.4818955361843109, "2079": 0.417115718126297, "2... | 10624000 | During continuous speech, lip movements provide visual temporal signals that facilitate speech processing. Here, using MEG we directly investigated how these visual signals interact with rhythmic brain activity in participants listening to and seeing the speaker. First, we investigated coherence between oscillatory bra... | Lip movements entrain the observers’ low-frequency brain oscillations to facilitate speech intelligibility |
{"1011": 0.30917787551879883, "1013": 0.1011524572968483, "1015": 0.1913948506116867, "1017": 0.1384023278951645, "1019": 0.36697331070899963, "1040": 0.21135559678077698, "1044": 0.6038249135017395, "1045": 0.6714286804199219, "1048": 0.7647408246994019, "1996": 0.007782140281051397, "2002": 0.8941729068756104, "2008"... | 10627801 | The DExD/H box RNA helicase retinoic acid-inducible gene I (RIG-I) and the melanoma differentiation-associated gene 5 (MDA5) are key intracellular receptors that recognize virus infection to produce type I IFN. A third helicase gene, Lgp2, is homologous to Rig-I and Mda5 but lacks a caspase activation and recruitment d... | Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. |
{"1011": 0.5104349255561829, "1017": 0.07341018319129944, "1040": 0.3683255612850189, "1042": 0.2763880789279938, "1052": 0.4537591338157654, "1062": 0.6517757177352905, "1997": 0.06703783571720123, "2003": 0.10379679501056671, "2005": 0.03360854089260101, "2028": 0.13670019805431366, "2029": 0.11951763927936554, "2048... | 10628767 | We demonstrate single-molecule fluorescence imaging beyond the optical diffraction limit in 3 dimensions with a wide-field microscope that exhibits a double-helix point spread function (DH-PSF). The DH-PSF design features high and uniform Fisher information and has 2 dominant lobes in the image plane whose angular orie... | Three-dimensional, single-molecule fluorescence imaging beyond the diffraction limit by using a double-helix point spread function. |
{"1011": 0.18816383183002472, "1015": 0.3388410806655884, "1016": 0.05046287178993225, "1017": 0.4400174915790558, "1039": 0.2837681770324707, "1051": 0.08603433519601822, "1058": 0.40546512603759766, "1996": 0.21135559678077698, "2003": 0.02792670577764511, "2008": 0.02792670577764511, "2011": 0.08513788133859634, "20... | 10641162 | In contrast to the cell division machineries of bacteria, euryarchaea, and eukaryotes, no division components have been identified in the second main archaeal phylum, Crenarchaeota. Here, we demonstrate that a three-gene operon, cdv, in the crenarchaeon Sulfolobus acidocaldarius, forms part of a unique cell division ma... | A unique cell division machinery in the Archaea. |
{"1040": 0.469759464263916, "1055": 0.12986256182193756, "1061": 0.37707099318504333, "2003": 0.34023189544677734, "2006": 0.053244512528181076, "2011": 0.029824240133166313, "2013": 0.04953393340110779, "2015": 0.46363574266433716, "2029": 0.0770333781838417, "2046": 0.06703783571720123, "2050": 0.31489628553390503, "... | 10641715 | Down syndrome (trisomy 21) is the most common viable chromosomal disorder with intellectual impairment and several other developmental abnormalities. Here, we report the generation and characterization of induced pluripotent stem cells (iPSCs) derived from monozygotic twins discordant for trisomy 21 in order to elimina... | Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21 |
{"1009": 0.4196864068508148, "1011": 0.33115679025650024, "1015": 0.6358738541603088, "1018": 0.037378571927547455, "1040": 0.15023678541183472, "1048": 0.6538092494010925, "1052": 0.3850763738155365, "1056": 1.005902886390686, "1998": 0.15359249711036682, "2006": 0.03360854089260101, "2007": 0.06886265426874161, "2011... | 10648422 | Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection. Programmed death-1 (PD-1) and interleukin-10 (IL-10) are both upregulated during HIV infection. Blocking interactions... | Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection |
{"1005": 0.06612417846918106, "1011": 0.09050461649894714, "1017": 0.5478278398513794, "1019": 0.6734226942062378, "1041": 0.8861536383628845, "1996": 0.12728634476661682, "2006": 0.06977381557226181, "2011": 0.3084607720375061, "2028": 0.2409527748823166, "2029": 0.21765978634357452, "2043": 0.10379679501056671, "2048... | 10650521 | Exonic splicing enhancers (ESEs) facilitate exon definition by assisting in the recruitment of splicing factors to the adjacent intron. Here we demonstrate that suboptimal 5' and 3' splice sites are activated independently by ESEs when they are located on different exons. However, when they are situated within a single... | A general role for splicing enhancers in exon definition. |
{"1011": 0.34023189544677734, "1046": 0.026976587250828743, "1055": 0.043007105588912964, "1997": 0.06154331564903259, "1999": 0.17840765416622162, "2003": 0.06520967930555344, "2005": 0.35334911942481995, "2007": 0.2786078155040741, "2011": 0.29981520771980286, "2025": 0.4512746334075928, "2029": 0.25995752215385437, ... | 10660080 | SecDFyajC of Escherichia coli is required for efficient export of proteins in vivo. However, the functional role of SecDFyajC in protein translocation is unclear. We evaluated the postulated function of SecDFyajC in the maintenance of the proton motive force. As previously reported, inner membrane vesicles (IMVs) lacki... | SecDFyajC is not required for the maintenance of the proton motive force. |
{"1011": 0.0009760859538801014, "1017": 0.3170322775840759, "1048": 0.32270604372024536, "1056": 0.6624060273170471, "1059": 0.8666408061981201, "2003": 0.17759032547473907, "2005": 0.11778303235769272, "2011": 0.1477125883102417, "2012": 0.4286321699619293, "2013": 0.21765978634357452, "2029": 0.058784693479537964, "2... | 10666475 | Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds ... | The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase |
{"1011": 0.16524957120418549, "1043": 0.1485546976327896, "1047": 0.7683706283569336, "1056": 0.16110190749168396, "1156": 0.4770587682723999, "1999": 0.04207121208310127, "2004": 0.09850110858678818, "2006": 0.20818853378295898, "2007": 0.5421652793884277, "2008": 0.04487626627087593, "2011": 0.3870677351951599, "2029... | 10669582 | The protein cross-linking enzyme tissue transglutaminase binds in vitro with high affinity to fibronectin via its 42-kD gelatin-binding domain. Here we report that cell surface transglutaminase mediates adhesion and spreading of cells on the 42-kD fibronectin fragment, which lacks integrin-binding motifs. Overexpressio... | Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin |
{"1009": 0.5290185213088989, "1011": 0.28670501708984375, "1015": 0.18978065252304077, "1016": 0.014542185701429844, "1019": 0.1710275560617447, "1040": 0.0038986403960734606, "1043": 0.1384023278951645, "1054": 0.7333439588546753, "1056": 0.9225212931632996, "1999": 0.07250232994556427, "2000": 0.0058422754518687725, ... | 10669939 | Imaging the expression of successful gene transduction has been demonstrated in vivo for the first time by using an appropriate combination of "marker gene" and "marker substrate" in an experimental animal model. The herpes simplex virus 1 thymidine kinase (HSV1-tk) gene was selected as an example of a marker gene, and... | Imaging the expression of transfected genes in vivo. |
{"1052": 0.04487626627087593, "1996": 0.0354953333735466, "2003": 0.013579257763922215, "2011": 0.4425300657749176, "2029": 0.083342544734478, "2044": 0.3601844012737274, "2047": 0.319873183965683, "2064": 0.1710275560617447, "2075": 0.2231435477733612, "2076": 0.07159364968538284, "2079": 0.23556606471538544, "2098": ... | 10670430 | The clearance of apoptotic cells by phagocytes is an integral component of normal life, and defects in this process can have significant implications for self tolerance and autoimmunity. Recent studies have provided new insights into the engulfment process, including how phagocytes seek apoptotic cells, how they recogn... | Engulfment of apoptotic cells: signals for a good meal |
{"1044": 0.053244512528181076, "1045": 0.7665573358535767, "1046": 0.6139179468154907, "1999": 0.040196798741817474, "2003": 0.31204116344451904, "2007": 0.13243216276168823, "2011": 0.055094651877880096, "2013": 0.09761575609445572, "2020": 0.04207121208310127, "2029": 0.0913962796330452, "2048": 0.15860503911972046, ... | 10675756 | BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG autoantibodies. It is not known whether this represents a local mucosal response which has switched to IgG or a peripheral response which may have been initiated by perip... | Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis. |
{"1047": 0.02316705882549286, "1055": 0.13499516248703003, "1057": 0.30989447236061096, "2000": 0.23092569410800934, "2003": 0.09938567131757736, "2005": 0.18329764902591705, "2011": 0.23633737862110138, "2034": 0.21687394380569458, "2048": 0.2719337046146393, "2064": 0.3409265875816345, "2072": 0.16442140936851501, "2... | 10692412 | BACKGROUND Kulldorff's spatial scan statistic and its software implementation - SaTScan - are widely used for detecting and evaluating geographic clusters. However, two issues make using the method and interpreting its results non-trivial: (1) the method lacks cartographic support for understanding the clusters in geog... | Geovisual analytics to enhance spatial scan statistic interpretation: an analysis of U.S. cervical cancer mortality |
{"1014": 0.1619328260421753, "1018": 0.12470348179340363, "1019": 0.4067663550376892, "1021": 0.0913962796330452, "1040": 0.11168810725212097, "1048": 0.17431432008743286, "1050": 0.12986256182193756, "1052": 0.3519764244556427, "1998": 0.08244366943836212, "1999": 0.010684899985790253, "2001": 0.11517547070980072, "20... | 10692948 | CONTEXT Early childhood introduction of nutritional habits aimed at atherosclerosis prevention is compatible with normal growth, but its effect on neurological development is unknown. OBJECTIVE To analyze how parental counseling aimed at keeping children's diets low in saturated fat and cholesterol influences neurodeve... | Neurological development of 5-year-old children receiving a low-saturated fat, low-cholesterol diet since infancy: A randomized controlled trial. |
{"1011": 0.20580662786960602, "1019": 0.08603433519601822, "1048": 0.34922540187835693, "1060": 0.38905516266822815, "2000": 0.07250232994556427, "2011": 0.37974658608436584, "2029": 0.21372433006763458, "2044": 0.2674594223499298, "2051": 0.07884006202220917, "2076": 0.3662964701652527, "2094": 0.48430517315864563, "2... | 10697096 | BACKGROUND The purpose of this study was to test the hypothesis that vasodilator responses of porcine coronary resistance arteries are increased by exercise training. METHODS AND RESULTS Yucatan miniature swine were randomly divided into groups of exercise-trained (ET) and sedentary (SED) control pigs. ET pigs were pla... | Vasodilator responses of coronary resistance arteries of exercise-trained pigs. |
{"1009": 0.05970508232712746, "1011": 0.012615402229130268, "1013": 0.037378571927547455, "1016": 0.28743788599967957, "1044": 0.8408597707748413, "1051": 0.7286425232887268, "1055": 0.43244171142578125, "2002": 0.41065993905067444, "2004": 0.0058422754518687725, "2007": 0.12384103983640671, "2011": 0.15359249711036682... | 10698739 | Loss of Omi/HtrA2 function leads to nerve cell loss in mouse models and has been linked to neurodegeneration in Parkinson's and Huntington's disease. Omi/HtrA2 is a serine protease released as a pro-apoptotic factor from the mitochondrial intermembrane space into the cytosol. Under physiological conditions, Omi/HtrA2 i... | Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1. |
{"1009": 0.20660123229026794, "1011": 0.2034190446138382, "1015": 0.25088030099868774, "1016": 0.2749055027961731, "1017": 0.4203280806541443, "1018": 0.2976420819759369, "1019": 0.24248650670051575, "1020": 0.29036402702331543, "1022": 0.29328158497810364, "1043": 0.8534175157546997, "1048": 0.7153595685958862, "1050"... | 10699587 | PURPOSE Gleason score (GS), T stage, and pathologic lymph node status have been described as major independent predictors of death due to prostate cancer in men treated with external beam radiotherapy (XRT). In this analysis we combine these three factors to define prognostic subgroups that correlate with disease-speci... | Four prognostic groups predict long-term survival from prostate cancer following radiotherapy alone on Radiation Therapy Oncology Group clinical trials. |
{"1014": 0.3262358605861664, "1018": 0.22392450273036957, "1019": 0.20739519596099854, "1022": 0.040196798741817474, "1038": 0.9379299283027649, "1042": 0.026976587250828743, "1048": 0.1970241367816925, "1999": 0.01934296265244484, "2005": 0.10993985831737518, "2011": 0.19782574474811554, "2020": 0.0354953333735466, "2... | 10703001 | Administration of 0.5 mg bleomycin to mice twice weekly for 4 weeks induced pulmonary fibrosis. The initial site of injury was the intima of pulmonary arteries and veins where endothelial cells became edematous and were separated from the underlying basement membrane by large blebs. These lesions occurred after 2 weeks... | The pathogenesis of bleomycin-induced pulmonary fibrosis in mice. |
{"1040": 0.07431721687316895, "2003": 0.02887592278420925, "2033": 0.35745587944984436, "2043": 0.0606246218085289, "2044": 0.15860503911972046, "2064": 0.28670501708984375, "2076": 0.7352184057235718, "2079": 0.20739519596099854, "2083": 0.16690383851528168, "2084": 0.06612417846918106, "2099": 1.1683861017227173, "21... | 10704438 | Cells are equipped with a cell-intrinsic signaling network called the DNA damage response (DDR). This signaling network recognizes DNA lesions and initiates various downstream pathways to coordinate a cell cycle arrest with the repair of the damaged DNA. Alternatively, the DDR can mediate clearance of affected cells th... | The DNA damage response during mitosis. |
{"1011": 0.21922965347766876, "1043": 0.4518963396549225, "2003": 0.26446542143821716, "2054": 0.3177432417869568, "2079": 0.20102575421333313, "2109": 0.2470736801624298, "2224": 0.11081436276435852, "2236": 0.4812922179698944, "2241": 1.151856780052185, "2338": 0.7408206462860107, "2405": 0.11343330889940262, "2455":... | 10743131 | Geostatistics is concerned with estimation and prediction problems for spatially continuous phenomena, using data obtained at a limited number of spatial locations. Model-based geostatistics refers to the application of general statistical principles of modelling and inference to geostatisatical problems. This volume i... | Model-based Geostatistics |
{"1011": 0.03831886500120163, "1021": 0.22079704701900482, "1022": 0.3588210940361023, "1054": 0.40285754203796387, "2001": 0.029824240133166313, "2004": 0.16359257698059082, "2009": 0.10467668622732162, "2022": 0.18573370575904846, "2025": 0.21765978634357452, "2034": 0.02887592278420925, "2035": 0.3743882179260254, "... | 10749308 | Placebo-controlled trials are used extensively in the development of new pharmaceuticals. They are sometimes challenged as unethical in settings in which patients could be treated with an existing therapy (1-7). The issues of when placebo controls are ethically acceptable and when they are scientifically necessary are ... | Placebo-Controlled Trials and Active-Control Trials in the Evaluation of New Treatments. Part 1: Ethical and Scientific Issues |
{"1003": 0.15275461971759796, "1048": 0.2493593990802765, "1997": 0.24859806895256042, "1998": 0.10379679501056671, "1999": 0.32199856638908386, "2007": 0.37707099318504333, "2018": 0.0038986403960734606, "2019": 0.030771657824516296, "2025": 0.10731173306703568, "2031": 0.11951763927936554, "2037": 0.26146242022514343... | 10761515 | In 30 patients with cancer of the large bowel, 24 (80%) had detectable levels of methane in their breath, compared with 25 (39%) of 64 patients with non-malignant large-bowel disease and 83 (40%) of 208 subjects without large-bowel disease. These findings suggest that there may be a difference in anaerobic intestinal f... | Breath-methane in patients with cancer of the large bowel. |
{"1043": 0.35677260160446167, "1048": 0.3824150264263153, "1056": 0.9194108247756958, "1996": 0.06703783571720123, "1999": 0.04674193635582924, "2011": 0.30558720231056213, "2029": 0.28670501708984375, "2071": 0.05139094591140747, "2073": 0.3750596046447754, "2075": 0.0770333781838417, "2076": 0.18816383183002472, "207... | 10765888 | Neurogenesis is known to take place in the adult brain. This work identifies T lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood. Hippocampal neurogenesis induced by an enriched environment was associated with the recruitment of T cel... | Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood |
{"1011": 0.07341018319129944, "2011": 0.11430477350950241, "2012": 0.3949938118457794, "2013": 0.010684899985790253, "2025": 0.04767346754670143, "2029": 0.07884006202220917, "2037": 0.0354953333735466, "2042": 0.07250232994556427, "2048": 0.36494144797325134, "2058": 0.9209672808647156, "2070": 0.18816383183002472, "2... | 10766688 | Population diversity data have recently provided profound, albeit inferential, insights into meiotic recombination across the human genome, revealing a landscape dominated by thousands of cross-over hotspots. However, very few of these putative hotspots have been directly analyzed for cross-over activity. We now descri... | Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association. |
{"1011": 0.09317722171545029, "1018": 0.06795065850019455, "1041": 0.18004031479358673, "1047": 0.48670899868011475, "1048": 0.19622190296649933, "1056": 0.05046287178993225, "1155": 0.5393219590187073, "1997": 0.06520967930555344, "2000": 0.176772341132164, "2003": 0.06703783571720123, "2005": 0.19622190296649933, "20... | 10786948 | The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use patient-specific somatic cells, which are a valuable source for disease modeling and drug discovery. To promote research involving these cells, it is important to make iPSCs from easily accessible and less invasive tissues, like bl... | An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. |
{"1018": 0.38574060797691345, "1038": 0.2969166338443756, "2007": 0.040196798741817474, "2011": 0.4196864068508148, "2012": 0.40806588530540466, "2029": 0.0797421783208847, "2036": 0.02412080205976963, "2047": 0.5651806592941284, "2048": 0.2786078155040741, "2063": 0.3622259199619293, "2076": 0.38441169261932373, "2089... | 10790846 | Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new proteins. For example, long-term potentiation (LTP) that endures for more than an hour requires both transcription and translation. The signal-transduction mechanisms that couple synaptic events to protein translational machinery... | A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. |
{"1011": 0.10291612148284912, "1037": 0.3897167444229126, "1039": 0.0317181795835495, "1041": 0.4770587682723999, "1049": 0.22859740257263184, "1156": 0.5995445251464844, "1999": 0.06977381557226181, "2005": 0.020300358533859253, "2011": 0.3127557039260864, "2029": 0.17759032547473907, "2076": 0.06429435312747955, "209... | 10795063 | SPECIFIC AIMSOur previous studies implied the relation between lipid metabolism and amyloid beta protein (Aβ) as ‘a missing link in Alzheimer’s puzzle’ [FASEB J., vol. 12, p. 1097 (1998)]. In the present study, we evaluated the role of cholesterol in synaptic plasticity and neuronal degeneration by a combination of adu... | The FASEB Journal express article 10.1096/fj.00-0815fje. Published online June 27, 2001. Essential role for cholesterol in synaptic plasticity and neuronal degeneration |
{"1009": 0.10555581003427505, "1011": 0.16442140936851501, "1017": 0.3464667797088623, "1039": 0.02792670577764511, "1048": 0.0174254160374403, "1049": 0.07250232994556427, "1051": 0.5729197263717651, "2003": 0.006812678650021553, "2026": 0.8357921838760376, "2029": 0.043007105588912964, "2063": 0.2018241584300995, "20... | 10795340 | Pancytopenia is a major cause of morbidity in acute myeloid leukemia (AML), yet its cause is unclear. Normal osteoblastic cells have been shown to support hematopoiesis. To define the effects of leukemia on osteoblastic cells, we used an immunocompetent murine model of AML. Leukemic mice had inhibition of osteoblastic ... | Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. |
{"1038": 0.06795065850019455, "1042": 0.4041621685028076, "1996": 0.04113444685935974, "2015": 0.6714286804199219, "2024": 0.07159364968538284, "2044": 0.1401015669107437, "2054": 0.11778303235769272, "2075": 0.18492233753204346, "2076": 0.4002431631088257, "2079": 0.5427330136299133, "2107": 0.04953393340110779, "2109... | 10812605 | Fibroblasts regulate the structure and function of healthy tissues, participate transiently in tissue repair after acute inflammation, and assume an aberrant stimulatory role during chronic inflammatory states including cancer. Such cancer-associated fibroblasts (CAFs) modulate the tumor microenvironment and influence ... | Fibroblast heterogeneity in the cancer wound |
{"1039": 0.09228714555501938, "1053": 0.19220098853111267, "1061": 0.6892333030700684, "2001": 0.09761575609445572, "2003": 0.27934664487838745, "2015": 0.05046287178993225, "2020": 0.11778303235769272, "2024": 0.0174254160374403, "2037": 0.0029254043474793434, "2043": 0.18654440343379974, "2072": 0.1212492436170578, "... | 10827901 | The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative longitudinal survey of persons in China 45 years of age or older and their spouses, including assessments of social, economic, and health circumstances of community-residents. CHARLS examines health and economic adjustments to ra... | Cohort profile: the China Health and Retirement Longitudinal Study (CHARLS). |
{"1009": 0.14179791510105133, "1011": 0.18411032855510712, "1016": 0.49030399322509766, "1038": 0.38308101892471313, "1049": 0.4764525294303894, "1055": 0.11778303235769272, "1056": 0.9417452812194824, "1999": 0.3353555500507355, "2003": 0.17431432008743286, "2004": 0.006812678650021553, "2015": 0.07068414986133575, "2... | 10831818 | OBJECTIVE Multiple sclerosis (MS) is a disease of the central nervous system with marked heterogeneity in several aspects including pathological processes. Based on infiltrating immune cells, deposition of humoral factors and loss of oligodendrocytes and/or myelin proteins, four lesion patterns have been described. Pat... | Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions |
{"1006": 0.1677299439907074, "1009": 0.49864232540130615, "1011": 0.1930064558982849, "1016": 0.4512746334075928, "1018": 0.21135559678077698, "1019": 0.272677481174469, "1042": 0.8861536383628845, "1050": 0.5092619061470032, "1052": 0.7755908370018005, "1058": 0.21922965347766876, "1996": 0.48430517315864563, "1998": ... | 10846815 | The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast cells induces oscillations in Ca(2+) and PtdIns(4,5)P(2) lipid levels that in turn drive cyclic recruitment of N-WASP a... | Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion |
{"1009": 0.35334911942481995, "1011": 0.18004031479358673, "1015": 0.32553088665008545, "1017": 0.09406650811433792, "1023": 0.18978065252304077, "1043": 0.4093637466430664, "1047": 0.06337817758321762, "1048": 0.1485546976327896, "1059": 0.7445381283760071, "1062": 0.5021947622299194, "2004": 0.6882523894309998, "2005... | 10852047 | We recently developed a class of novel antitumor agents that elicit a potent growth-inhibitory response in many tumor cells cultured in vitro. WK175, a member of this class, was chosen as a model compound that showed strong in vitro efficacy. WK175 interferes with the intracellular steady-state level of NAD(+), resulti... | WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells. |
{"1014": 0.06886265426874161, "1023": 0.0038986403960734606, "1038": 0.4794800877571106, "1044": 0.034552380442619324, "1050": 0.4337083101272583, "1998": 0.18654440343379974, "1999": 0.11256109178066254, "2000": 0.06886265426874161, "2011": 0.022212404757738113, "2012": 0.3601844012737274, "2020": 0.1751343309879303, ... | 10854174 | BACKGROUND A primary cause of high maternal mortality in Bangladesh is lack of access to professional delivery care. Examining the role of the family, particularly the husband, during pregnancy and childbirth is important to understanding women's access to and utilization of professional maternal health services that c... | Husbands' involvement in delivery care utilization in rural Bangladesh: A qualitative study |
{"1011": 0.2637155055999756, "1015": 0.014542185701429844, "1038": 0.3588210940361023, "1040": 0.7305257320404053, "1609": 0.129004567861557, "2004": 0.06977381557226181, "2008": 0.05139094591140747, "2011": 0.32905077934265137, "2012": 0.1485546976327896, "2013": 0.06886265426874161, "2015": 0.13414156436920166, "2020... | 10874408 | DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad50S or sae2Δ mutants, which are defective in break processing, to accumulate Spo11-linked DSBs, and report large (≥ 50 kb) “DSB-hot” regions that are separated by “DSB-cold” ... | Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae |
{"1014": 0.2501201331615448, "1038": 0.6096806526184082, "1052": 0.8091925978660583, "1054": 0.6369074583053589, "1999": 0.43244171142578125, "2000": 0.1751343309879303, "2002": 0.8989537954330444, "2004": 0.3982778787612915, "2006": 0.18004031479358673, "2007": 0.39696553349494934, "2010": 0.5957841277122498, "2013": ... | 10883736 | CONTEXT The mechanisms that drive progression from fatty liver to steatohepatitis and cirrhosis are unknown. In animal models, obese mice with fatty livers are vulnerable to liver adenosine triphosphate (ATP) depletion and necrosis, suggesting that altered hepatic energy homeostasis may be involved. OBJECTIVE To determ... | Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study. |
{"1011": 0.08961215615272522, "1016": 0.16524957120418549, "1017": 0.5979346632957458, "1047": 0.3662964701652527, "1052": 0.5990082025527954, "1998": 0.22626367211341858, "1999": 0.2184450328350067, "2005": 0.08513788133859634, "2011": 0.23556606471538544, "2029": 0.23633737862110138, "2046": 0.5444341897964478, "2064... | 10889845 | Obesity and insulin resistance, the key features of metabolic syndrome, are closely associated with a state of chronic, low-grade inflammation characterized by abnormal macrophage infiltration into adipose tissues. Although it has been reported that chemokines promote leukocyte migration by activating class IB phosphoi... | Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. |
{"1039": 0.401551216840744, "1059": 0.14264501631259918, "2001": 0.13071982562541962, "2003": 0.18654440343379974, "2004": 0.08961215615272522, "2005": 0.26146242022514343, "2011": 0.14939609169960022, "2015": 0.24401791393756866, "2020": 0.058784693479537964, "2040": 0.1994270235300064, "2054": 0.007782140281051397, "... | 10893238 | BACKGROUND Frail and dependent older people in resource-poor settings are poorly served by health systems that lack outreach capacity. The COPE (Caring for Older PEople) multidimensional assessment tool is designed to help community health workers (CHWs) identify clinically significant impairments and deliver evidence-... | Identifying common impairments in frail and dependent older people: validation of the COPE assessment for non-specialised health workers in low resource primary health care settings |
{"1011": 0.15526613593101501, "1018": 0.08961215615272522, "1021": 0.7737906575202942, "1022": 0.38308101892471313, "1038": 0.14179791510105133, "1039": 0.4891071021556854, "1050": 0.41195443272590637, "1057": 0.1221139207482338, "2003": 0.3012613356113434, "2004": 0.16524957120418549, "2008": 0.09495500475168228, "201... | 10906636 | US28 is one of four 7 transmembrane (7TM) chemokine receptors encoded by human cytomegalovirus and has been shown to both signal and endocytose in a ligand-independent, constitutively active manner. Here we show that the constitutive activity and constitutive endocytosis properties of US28 are separable entities in thi... | The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. |
{"1017": 0.08513788133859634, "1041": 0.6739205718040466, "1044": 0.129004567861557, "2003": 0.12038381397724152, "2011": 0.06977381557226181, "2048": 0.43875885009765625, "2075": 0.1677299439907074, "2083": 0.3077431619167328, "2089": 0.1734936386346817, "2090": 0.15693697333335876, "2093": 0.4041621685028076, "2129":... | 10931595 | Developmental signaling networks are composed of dozens of components whose interactions are very difficult to quantify in an embryo. Geometric reasoning enumerates a discrete hierarchy of phenotypic models with a few composite variables whose parameters may be defined by in vivo data. Vulval development in the nematod... | Geometry, epistasis, and developmental patterning. |
{"1011": 0.013579257763922215, "1017": 0.0174254160374403, "1039": 0.6075552701950073, "1041": 0.3622259199619293, "1044": 0.27342069149017334, "1996": 0.27786844968795776, "1997": 0.15943801403045654, "2007": 0.12814582884311676, "2011": 0.34715715050697327, "2015": 0.16359257698059082, "2029": 0.10291612148284912, "2... | 10937190 | The morphogenesis of the C. elegans embryo is largely controlled by the development of the epidermis, also known as the hypodermis, a single epithelial layer that surrounds the animal. Morphogenesis of the epidermis involves cell-cell interactions with internal tissues, such as the developing nervous system and muscula... | Table of Contents |
{"1011": 0.02887592278420925, "1014": 0.4891071021556854, "1015": 0.5139457583427429, "1048": 1.0389231443405151, "1997": 0.15860503911972046, "2012": 0.23633737862110138, "2013": 0.04113444685935974, "2015": 0.17020416259765625, "2020": 0.0354953333735466, "2028": 0.28155985474586487, "2029": 0.06154331564903259, "203... | 10944947 | Using high-throughput sequencing, we devised a technique to determine the insertion sites of virtually all members of the human-specific L1 retrotransposon family in any human genome. Using diagnostic nucleotides, we were able to locate the approximately 800 L1Hs copies corresponding specifically to the pre-Ta, Ta-0, a... | High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes. |
{"1003": 0.10818854719400406, "1011": 0.07793712615966797, "1014": 0.08782484382390976, "1018": 0.38308101892471313, "1023": 0.043007105588912964, "1052": 0.2317005842924118, "2001": 0.18573370575904846, "2007": 0.24631060659885406, "2020": 0.11604541540145874, "2035": 0.11256109178066254, "2042": 0.04394211992621422, ... | 10958594 | The aim of this study was to determine trends in incidence, treatment and survival of colorectal cancer (CRC) patients with synchronous metastases (Stage IV) in the Netherlands. This nationwide population-based study included 160,278 patients diagnosed with CRC between 1996 and 2011. We evaluated changes in stage distr... | Nationwide trends in incidence, treatment and survival of colorectal cancer patients with synchronous metastases |
{"1005": 0.10379679501056671, "1038": 1.225611925125122, "1041": 0.8893690705299377, "1048": 0.46117570996284485, "1055": 0.5092619061470032, "1999": 0.07884006202220917, "2001": 0.3910386264324188, "2007": 0.3897167444229126, "2010": 0.05970508232712746, "2026": 0.8829278349876404, "2029": 0.26296505331993103, "2034":... | 10976596 | Burkitt's lymphoma (BL) was first described 50 years ago, and the first human tumour virus Epstein–Barr virus (EBV) was discovered in BL tumours soon after. Since then, the role of EBV in the development of BL has become more and more enigmatic. Only recently have we finally begun to understand, at the cellular and mol... | The curious case of the tumour virus: 50 years of Burkitt's lymphoma |
{"1041": 0.10731173306703568, "1048": 0.2918238639831543, "1997": 0.11951763927936554, "1999": 0.083342544734478, "2004": 0.04113444685935974, "2005": 0.018384648486971855, "2011": 0.0752234235405922, "2013": 0.1332872211933136, "2015": 0.029824240133166313, "2038": 0.08513788133859634, "2039": 0.5871354341506958, "204... | 10982689 | Although humans have been exposed to airborne nanosized particles (NSPs; < 100 nm) throughout their evolutionary stages, such exposure has increased dramatically over the last century due to anthropogenic sources. The rapidly developing field of nanotechnology is likely to become yet another source through inhalation, ... | Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles |
{"1003": 0.025073638185858727, "1014": 0.25088030099868774, "1057": 0.1619328260421753, "1999": 0.043007105588912964, "2001": 0.06246116757392883, "2005": 0.2822965085506439, "2026": 0.22859740257263184, "2043": 0.2478361576795578, "2047": 0.4374985992908478, "2060": 0.2741633653640747, "2064": 0.08513788133859634, "20... | 10984005 | CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can increase heart rate and blood pressure, raising concerns about their cardiovascular safety. OBJECTIVE To examine whether current use of medications pres... | ADHD medications and risk of serious cardiovascular events in young and middle-aged adults. |
{"1011": 0.20739519596099854, "1015": 0.13414156436920166, "1042": 0.6275664567947388, "1043": 0.10026945173740387, "1044": 0.5209306478500366, "1048": 0.1685553640127182, "1054": 0.7009293437004089, "2006": 0.11951763927936554, "2008": 0.007782140281051397, "2011": 0.3283478021621704, "2029": 0.16690383851528168, "203... | 10991183 | How individual cells respond to mechanical forces is of considerable interest to biologists as force affects many aspects of cell behaviour. The application of force on integrins triggers cytoskeletal rearrangements and growth of the associated adhesion complex, resulting in increased cellular stiffness, also known as ... | The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins |
{"1044": 0.16442140936851501, "1051": 0.04860413447022438, "1054": 0.26146242022514343, "2011": 0.1685553640127182, "2015": 0.7951818704605103, "2020": 0.09228714555501938, "2025": 0.5261374711990356, "2037": 0.045809537172317505, "2047": 0.10906458646059036, "2053": 0.12728634476661682, "2064": 0.040196798741817474, "... | 10993232 | Recent observations have suggested that classic antibiotics kill bacteria by stimulating the formation of reactive oxygen species (ROS). If true, this notion might guide new strategies to improve antibiotic efficacy. In this study, the model was directly tested. Contrary to the hypothesis, antibiotic treatment did not ... | Cell death from antibiotics without the involvement of reactive oxygen species. |
{"1007": 0.034552380442619324, "1011": 0.007782140281051397, "1038": 0.1485546976327896, "1047": 0.57457035779953, "1056": 1.0628231763839722, "2006": 0.17922431230545044, "2007": 0.010684899985790253, "2008": 0.11778303235769272, "2010": 0.7398891448974609, "2011": 0.3485364317893982, "2026": 0.34715715050697327, "202... | 11011905 | Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes, using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a winged helix DBD that resembles linker histone and thereby binds its target sites on nucleosomes and in compacted chromatin. Herein, we comp... | Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming |
{"1017": 0.0770333781838417, "1020": 0.07159364968538284, "1050": 0.01934296265244484, "1059": 0.804835319519043, "1999": 0.0029254043474793434, "2011": 0.08692999184131622, "2015": 0.2667117714881897, "2020": 0.14518201351165771, "2029": 0.053244512528181076, "2062": 0.16524957120418549, "2064": 0.04207121208310127, "... | 11016410 | Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is reduced by stochastic and selective mechanisms that are incompletely understood. Defining how natural selection shapes RNA virus populations is crit... | Experimental Evolution of an RNA Virus in Wild Birds: Evidence for Host-Dependent Impacts on Population Structure and Competitive Fitness |
{"1011": 0.03831886500120163, "1039": 0.20421554148197174, "1042": 0.07884006202220917, "1055": 0.03925827145576477, "2003": 0.19220098853111267, "2004": 0.7009293437004089, "2005": 0.05046287178993225, "2028": 0.36697331070899963, "2054": 0.029824240133166313, "2072": 0.3622259199619293, "2090": 0.27044451236724854, "... | 11016788 | Data acquisition packages developed at different small angle scattering facilities use different formats both for raw and processed data storage. To facilitate the data exchange between laboratories, a consensus in the small angle scattering community has been reached on an ASCII format for one-dimensional data which i... | sasCIF: an extension of core Crystallographic Information File for SAS |
{"1009": 0.5562619566917419, "1011": 0.06337817758321762, "1022": 0.0797421783208847, "1039": 0.29400965571403503, "1040": 0.30558720231056213, "1041": 0.10906458646059036, "1045": 0.4132472574710846, "1048": 0.5197699069976807, "1049": 0.6853039860725403, "1056": 0.9621002674102783, "1999": 0.11430477350950241, "2004"... | 11020556 | Skin dendritic cells (DCs) are thought to act as key initiators of local T cell immunity. Here we show that after skin infection with herpes simplex virus (HSV), cytotoxic T lymphocyte (CTL) activation required MHC class I-restricted presentation by nonmigratory CD8(+) DCs rather than skin-derived DCs. Despite a lack o... | Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. |
{"1038": 0.3304552733898163, "2004": 0.025073638185858727, "2006": 0.15023678541183472, "2011": 0.021256839856505394, "2012": 0.19541899859905243, "2015": 0.00875066313892603, "2020": 0.10291612148284912, "2025": 0.24325250089168549, "2029": 0.03266380727291107, "2031": 0.15860503911972046, "2042": 0.04487626627087593,... | 11020675 | Megakaryocytes undergo a unique differentiation program, becoming polyploid through repeated cycles of DNA synthesis without concomitant cell division. However, the mechanism underlying this polyploidization remains totally unknown. It has been postulated that polyploidization is due to a skipping of mitosis after each... | Thrombopoietin-induced Polyploidization of Bone Marrow Megakaryocytes Is Due to a Unique Regulatory Mechanism in Late Mitosis |
{"1015": 0.0797421783208847, "1017": 0.2741633653640747, "1043": 0.19541899859905243, "1044": 0.7163142561912537, "2012": 0.018384648486971855, "2060": 0.04953393340110779, "2064": 0.20818853378295898, "2071": 0.0913962796330452, "2078": 0.7692760229110718, "2079": 0.05694137513637543, "2083": 0.09938567131757736, "208... | 11026600 | Information on global human movement patterns is central to spatial epidemiological models used to predict the behavior of influenza and other infectious diseases. Yet it remains difficult to test which modes of dispersal drive pathogen spread at various geographic scales using standard epidemiological data alone. Evol... | Unifying Viral Genetics and Human Transportation Data to Predict the Global Transmission Dynamics of Human Influenza H3N2 |
{"1011": 0.25694093108177185, "1017": 0.33675122261047363, "1019": 0.10555581003427505, "1022": 1.072225570678711, "1035": 0.08961215615272522, "1047": 0.28670501708984375, "1996": 0.052318159490823746, "1999": 0.0354953333735466, "2005": 0.07431721687316895, "2008": 0.022212404757738113, "2011": 0.11517547070980072, "... | 11041152 | Molecular motors play critical roles in the formation of mitotic spindles, either through controlling the stability of individual microtubules, or by crosslinking and sliding microtubule arrays. Kinesin-8 motors are best known for their regulatory roles in controlling microtubule dynamics. They contain microtubule-dest... | Microtubule sliding activity of a kinesin-8 promotes spindle assembly and spindle length control |
{"1011": 0.5723689198493958, "1017": 0.7665573358535767, "1047": 1.17624831199646, "1052": 0.9440274834632874, "1170": 0.043007105588912964, "2003": 0.07793712615966797, "2015": 0.1946154683828354, "2024": 0.1602703034877777, "2029": 0.11951763927936554, "2050": 0.5127768516540527, "2080": 0.1905880719423294, "2093": 0... | 11043831 | Phosphoinositide 3-kinases (PI3-Ks) are an important emerging class of drug targets, but the unique roles of PI3-K isoforms remain poorly defined. We describe here an approach to pharmacologically interrogate the PI3-K family. A chemically diverse panel of PI3-K inhibitors was synthesized, and their target selectivity ... | A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling |
{"1011": 0.07159364968538284, "1038": 0.4580921530723572, "1041": 1.0423725843429565, "1996": 0.129004567861557, "1999": 0.006812678650021553, "2006": 0.09850110858678818, "2007": 0.4512746334075928, "2008": 0.16110190749168396, "2011": 0.5197699069976807, "2013": 0.043007105588912964, "2029": 0.39433568716049194, "203... | 11048759 | The EBNA1 protein of Epstein-Barr virus (EBV) binds to and activates DNA replication from the EBV latent origin of replication, oriP, via a direct interaction with the two noncontiguous subelements of oriP. The EBNA1 molecules bound to the oriP subelements interact efficiently with each other by a DNA looping mechanism... | Identification of Epstein-Barr virus nuclear antigen 1 protein domains that direct interactions at a distance between DNA-bound proteins. |
{"1019": 0.07431721687316895, "1020": 0.3325583338737488, "1044": 1.0822023153305054, "2000": 0.7047978043556213, "2001": 0.21687394380569458, "2002": 0.08064348995685577, "2005": 0.5685047507286072, "2012": 0.04394211992621422, "2034": 0.3723714053630829, "2039": 0.2667117714881897, "2043": 0.4145384132862091, "2048":... | 11071351 | The National High Blood Pressure Education Program Coordinating Committee published its first statement on the primary prevention of hypertension in 1993. This article updates the 1993 report, using new and further evidence from the scientific literature. Current recommendations for primary prevention of hypertension i... | Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program. |
{"1011": 0.33953672647476196, "1018": 0.11778303235769272, "1048": 0.35060185194015503, "1052": 0.06612417846918106, "1996": 0.014542185701429844, "1997": 0.013579257763922215, "2003": 0.18248429894447327, "2008": 0.09850110858678818, "2011": 0.10026945173740387, "2024": 0.347847044467926, "2029": 0.13157635927200317, ... | 11083121 | The control of cell growth and polarity depends on a dynamic actin cytoskeleton that has the ability to reorganize in response to developmental and environmental stimuli. In animals and fungi, formins are just one of the four major classes of poly-L-proline-containing (PLP) proteins that form part of the signal-transdu... | Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization. |
{"1011": 0.3864043951034546, "1014": 0.012615402229130268, "1015": 0.6218147873878479, "1038": 0.2983669638633728, "1043": 0.9842413663864136, "1051": 0.2763880789279938, "1053": 0.32270604372024536, "1055": 0.36967599391937256, "1081": 0.8143964409828186, "1998": 0.04207121208310127, "2004": 0.011650617234408855, "202... | 11090688 | The weight lowering potential of glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) is inter-individually different and clinically unpredictable. The potential role of genetic variability of GLP-1R on body weight response to GLP-1 RAs in obese women with polycystic ovary syndrome (PCOS) has not yet been evaluated.... | Genetic variability in GLP-1 receptor is associated with inter-individual differences in weight lowering potential of liraglutide in obese women with PCOS: a pilot study |
{"1009": 0.0752234235405922, "1014": 0.034552380442619324, "1015": 0.151916041970253, "1016": 0.2478361576795578, "1018": 0.10379679501056671, "1022": 0.11081436276435852, "1042": 0.8433839678764343, "1045": 0.7163142561912537, "1051": 0.469759464263916, "1052": 0.004870930220931768, "1999": 0.32058215141296387, "2005"... | 11109043 | BACKGROUND To compare the clinical results and the cost-effectiveness of using the aromatase inhibitor, letrozole, in conjunction with FSH and FSH alone for controlled ovarian stimulation (COS) in patients undergoing intrauterine insemination (IUI) for a variety of indications. METHODS Four hundred and thirty-two conse... | Cost-effectiveness of aromatase inhibitor co-treatment for controlled ovarian stimulation. |
{"2010": 0.6202403903007507, "2084": 0.3850763738155365, "2095": 0.2954642176628113, "2099": 0.6128603219985962, "2109": 0.29473719000816345, "2119": 0.16442140936851501, "2128": 0.02792670577764511, "2132": 0.2830325961112976, "2166": 0.812664806842804, "2168": 0.022212404757738113, "2172": 0.5104349255561829, "2239":... | 11117498 | Solitary metastatic brain tumors are the most common intracranial neoplasms encountered by neurosurgeons. Surgical resection of brain metastasis with whole brain radiotherapy (WBR) significantly increases survival in comparison with WBR alone. Stereotactic radiosurgery (SR) seems to provide results that are similar to ... | The cost effectiveness of stereotactic radiosurgery versus surgical resection in the treatment of solitary metastatic brain tumors. |
{"1044": 0.47463157773017883, "1048": 0.13414156436920166, "2002": 1.0423725843429565, "2010": 0.021256839856505394, "2013": 0.34300774335861206, "2015": 0.09938567131757736, "2047": 0.15860503911972046, "2062": 0.22157983481884003, "2102": 0.7258110046386719, "2104": 0.3560888469219208, "2116": 0.056018441915512085, "... | 11117679 | Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection of data from 503 liver c... | Trans-ancestry mutational landscape of hepatocellular carcinoma genomes |
{"1011": 0.30917787551879883, "1017": 0.26446542143821716, "1019": 0.5718178153038025, "1039": 0.8691008687019348, "1044": 0.026976587250828743, "1996": 0.11081436276435852, "2024": 0.0354953333735466, "2029": 0.2447827309370041, "2035": 0.2749055027961731, "2048": 0.43812891840934753, "2057": 0.11256109178066254, "207... | 11141995 | Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a century their internal organization remains largely unsolved. We applied chromosome conformation capture methods, 5C and Hi-C, across the cell cycle and revealed two distinct three-dimensional folding states of the human genome. ... | Organization of the mitotic chromosome. |
{"1011": 0.18167030811309814, "1016": 0.272677481174469, "1055": 0.06612417846918106, "2001": 0.29473719000816345, "2003": 0.04767346754670143, "2004": 0.02887592278420925, "2015": 0.8238670229911804, "2034": 0.07068414986133575, "2040": 0.30989447236061096, "2043": 0.3910386264324188, "2048": 0.5778634548187256, "2052... | 11156883 | The concept of 'Compensatory anti-inflammatory response syndrome' (CARS) was proposed in 1997 by Roger Bone (1941-1997) to qualify the consequences of the counter-regulatory mechanisms initiated to limit the overzealous inflammatory process in patients with infectious (sepsis) or non-infectious systemic inflammatory re... | Compensatory anti-inflammatory response syndrome. |
{"1037": 0.18248429894447327, "2000": 0.08064348995685577, "2003": 0.35334911942481995, "2011": 0.2696990668773651, "2024": 0.11951763927936554, "2053": 0.043007105588912964, "2054": 0.49626702070236206, "2057": 0.016465263441205025, "2064": 0.25845035910606384, "2073": 0.015504186972975731, "2081": 0.07884006202220917... | 11172205 | A solid tumor is an organ composed of cancer and host cells embedded in an extracellular matrix and nourished by blood vessels. A prerequisite to understanding tumor pathophysiology is the ability to distinguish and monitor each component in dynamic studies. Standard fluorophores hamper simultaneous intravital imaging ... | Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo |
{"1011": 0.11168810725212097, "1015": 0.05417001247406006, "1021": 0.12728634476661682, "1022": 0.31845372915267944, "1045": 0.6729245185852051, "1999": 0.12814582884311676, "2004": 0.08244366943836212, "2007": 0.14179791510105133, "2011": 0.40285754203796387, "2029": 0.3656192123889923, "2030": 0.49864232540130615, "2... | 11181416 | Because arginase hydrolyzes arginine to produce ornithine and urea, it has the potential to regulate nitric oxide (NO) and polyamine synthesis. We tested whether expression of the cytosolic isoform of arginase (arginase I) was limiting for NO or polyamine production by activated RAW 264.7 macrophage cells. RAW 264.7 ce... | Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages? |
{"1011": 0.19782574474811554, "1042": 0.48430517315864563, "1052": 0.9761797785758972, "1055": 0.037378571927547455, "1056": 1.105748176574707, "1059": 0.5914691090583801, "1996": 0.5318912267684937, "2003": 0.4914994537830353, "2007": 0.10555581003427505, "2011": 0.3339579105377197, "2015": 0.08064348995685577, "2029"... | 11195653 | The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable IS formation and au... | Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse |
{"1011": 0.15610189735889435, "1015": 0.055094651877880096, "1017": 0.18329764902591705, "1156": 0.22001366317272186, "1157": 0.5629584193229675, "1998": 0.7995813488960266, "2003": 0.2749055027961731, "2007": 0.14179791510105133, "2011": 0.3903779089450836, "2012": 0.40546512603759766, "2029": 0.18329764902591705, "20... | 11200685 | Microtubule nucleation is an essential step in the formation of the microtubule cytoskeleton. We recently showed that androgen and Src promote microtubule nucleation and γ-tubulin accumulation at the centrosome. Here, we explore the mechanisms by which androgen and Src regulate these processes and ask whether integrins... | Integrins regulate microtubule nucleating activity of centrosome through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling. |
{"1011": 0.12038381397724152, "1013": 0.043007105588912964, "1014": 0.3963087201118469, "1022": 0.04394211992621422, "1050": 0.4145384132862091, "1060": 0.29981520771980286, "1061": 0.5433003902435303, "1998": 0.13414156436920166, "2007": 0.20660123229026794, "2058": 0.42353010177612305, "2072": 0.5662899017333984, "20... | 11201004 | Little is known about longitudinal associations between added sugar consumption (solid and liquid sources) and glucose-insulin homeostasis among youth. Caucasian children (8-10 y) with at least one obese biological parent were recruited in the QUébec Adipose and Lifestyle InvesTigation in Youth (QUALITY) cohort (n = 63... | Consumption of added sugars from liquid but not solid sources predicts impaired glucose homeostasis and insulin resistance among youth at risk of obesity. |
{"1013": 0.31489628553390503, "1017": 0.05694137513637543, "1997": 0.05139094591140747, "2000": 0.27564704418182373, "2005": 0.0770333781838417, "2038": 0.020300358533859253, "2039": 0.22001366317272186, "2042": 0.1693800985813141, "2043": 0.16690383851528168, "2047": 0.5301685929298401, "2052": 0.4145384132862091, "20... | 11230569 | Substantial changes are needed to achieve a more targeted and strategic approach to investment in the response to the HIV/AIDS epidemic that will yield long-term dividends. Until now, advocacy for resources has been done on the basis of a commodity approach that encouraged scaling up of numerous strategies in parallel,... | Towards an improved investment approach for an effective response to HIV/AIDS. |
{"1011": 0.401551216840744, "1020": 0.34300774335861206, "1054": 0.2659635543823242, "1056": 0.9546096324920654, "1155": 0.3134697377681732, "1999": 0.06795065850019455, "2002": 0.25239890813827515, "2005": 0.11865071207284927, "2008": 0.013579257763922215, "2011": 0.5021947622299194, "2024": 0.04487626627087593, "2029... | 11233339 | T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF- α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various infla... | Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases |
{"1048": 0.9680526852607727, "1054": 0.3027053773403168, "1060": 1.3580676317214966, "1996": 0.015504186972975731, "2002": 0.43812891840934753, "2003": 0.1718502640724182, "2005": 0.1677299439907074, "2008": 0.19782574474811554, "2024": 0.25088030099868774, "2029": 0.15610189735889435, "2048": 0.23710809648036957, "207... | 11238784 | Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively. In response to their ligands, these receptors induce transcriptional responses that maintain a balanced, finely tuned regulation of cholesterol and bile acid met... | LXRS and FXR: the yin and yang of cholesterol and fat metabolism. |
{"1005": 0.03925827145576477, "1011": 0.1970241367816925, "1017": 0.06886265426874161, "1018": 0.08154398202896118, "1022": 0.8212929964065552, "1041": 0.151916041970253, "1047": 0.567951500415802, "1048": 0.565735399723053, "1055": 0.4444103240966797, "1058": 0.05417001247406006, "2001": 0.10555581003427505, "2007": 0... | 11238951 | Kaposi's sarcoma-associated herpesvirus (KSHV), also termed human herpesvirus type 8, is consistently identified in Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. Here we report four cases of KSHV-bearing solid lymphomas that occurred in AIDS patients (cases 1 to 3) and in a hu... | Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8-positive solid lymphomas: a tissue-based variant of primary effusion lymphoma. |
{"1009": 0.6634125709533691, "1011": 0.436867892742157, "1013": 0.02412080205976963, "1016": 0.0058422754518687725, "1018": 0.011650617234408855, "1039": 0.43244171142578125, "1052": 0.12986256182193756, "1053": 0.0842406153678894, "1055": 0.011650617234408855, "2000": 0.09584271162748337, "2003": 0.083342544734478, "2... | 11244195 | MOTIVATION Accurate alignment of high-throughput RNA-seq data is a challenging and yet unsolved problem because of the non-contiguous transcript structure, relatively short read lengths and constantly increasing throughput of the sequencing technologies. Currently available RNA-seq aligners suffer from high mapping err... | STAR: ultrafast universal RNA-seq aligner. |
{"1014": 0.1401015669107437, "1018": 0.3750596046447754, "1019": 0.06154331564903259, "1038": 0.6212902665138245, "1040": 0.09050461649894714, "1045": 0.11168810725212097, "1048": 0.09050461649894714, "1054": 0.6583697199821472, "1060": 0.2447827309370041, "2005": 0.3353555500507355, "2012": 0.13414156436920166, "2044"... | 11246427 | CONTEXT Alendronate sodium reduces fracture risk in postmenopausal women who have vertebral fractures, but its effects on fracture risk have not been studied for women without vertebral fractures. OBJECTIVE To test the hypothesis that 4 years of alendronate would decrease the risk of clinical and vertebral fractures in... | Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. |
{"1011": 0.4374985992908478, "1015": 0.5784112811088562, "1016": 0.27786844968795776, "1017": 0.23556606471538544, "1038": 0.16110190749168396, "1039": 0.11343330889940262, "1058": 0.13157635927200317, "1060": 0.13670019805431366, "1996": 0.17267228662967682, "1999": 0.03266380727291107, "2011": 0.025073638185858727, "... | 11250124 | Synaptic vesicle recycling involves AP-2/clathrin-mediated endocytosis, but it is not known whether the endosomal pathway is also required. Mice deficient in the tissue-specific AP-1-sigma1B complex have impaired synaptic vesicle recycling in hippocampal synapses. The ubiquitously expressed AP-1-sigma1A complex mediate... | AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. |
{"1012": 0.13157635927200317, "1019": 0.4374985992908478, "1042": 0.5427330136299133, "1043": 0.49982786178588867, "1998": 0.018384648486971855, "2015": 0.11604541540145874, "2034": 0.01934296265244484, "2038": 0.09050461649894714, "2042": 0.026025565341114998, "2057": 0.026025565341114998, "2064": 0.07612881064414978,... | 11253758 | Upon the first publication of the fifth iteration of the Functional Annotation of Mammalian Genomes collaborative project, FANTOM5, we gathered a series of primary data and database systems into the FANTOM web resource (http://fantom.gsc.riken.jp) to facilitate researchers to explore transcriptional regulation and cell... | Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals |
{"1011": 0.4673144817352295, "1049": 0.3177432417869568, "1054": 0.01934296265244484, "2003": 0.20977331697940826, "2063": 0.8349450826644897, "2076": 0.0797421783208847, "2087": 0.23402166366577148, "2090": 0.05139094591140747, "2099": 0.9386941194534302, "2109": 0.06612417846918106, "2116": 0.1994270235300064, "2117"... | 11254040 | Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem. Due to long duration of therapy and concurrent use of multiple second-line drugs, adverse drug events (ADEs) are regarded as the most important clinical consideration in patients undergoing anti-MDR-TB treatment. To evaluate the frequency and... | Adverse Events Associated With the Treatment of Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis. |
{"1011": 0.20977331697940826, "1039": 0.5483922958374023, "1043": 0.4944818615913391, "1045": 0.5568217039108276, "1052": 0.791648268699646, "1055": 0.3864043951034546, "1999": 0.417115718126297, "2006": 0.27342069149017334, "2012": 0.2531573474407196, "2025": 0.1064341589808464, "2029": 0.18573370575904846, "2053": 0.... | 11254556 | Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states. Previous studies have functionally implicated the NMDA receptor-NO pathway and the downstream seco... | Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity |
{"1011": 0.20421554148197174, "1040": 0.16442140936851501, "1055": 0.31204116344451904, "1062": 0.5438674688339233, "2002": 0.09850110858678818, "2003": 0.32129061222076416, "2005": 0.15442965924739838, "2007": 0.13670019805431366, "2008": 0.10291612148284912, "2010": 0.16442140936851501, "2026": 1.2290464639663696, "2... | 11255504 | The Sleeping Beauty (SB) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC, one of the most commonly dysregulated genes in human malignancy. We performed a forward genetic scr... | A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer. |
{"1011": 0.4337083101272583, "1013": 0.05046287178993225, "1044": 0.43875885009765625, "1052": 0.6420594453811646, "1060": 0.14095009863376617, "1998": 0.4337083101272583, "2000": 0.013579257763922215, "2003": 0.03360854089260101, "2007": 0.2918238639831543, "2066": 0.36697331070899963, "2072": 1.104454517364502, "2090... | 11256632 | Protein-protein interactions (PPIs) represent an enormous source of opportunity for therapeutic intervention. We and others have recently pinpointed key rules that will help in identifying the next generation of innovative drugs to tackle this challenging class of targets within the next decade. We used these rules to ... | Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. |
{"1011": 0.07793712615966797, "1041": 0.24401791393756866, "1044": 0.21922965347766876, "1047": 0.6907027959823608, "1050": 0.25239890813827515, "1051": 0.129004567861557, "1052": 0.20739519596099854, "2003": 0.15442965924739838, "2006": 0.53589928150177, "2007": 0.21293537318706512, "2015": 0.29255300760269165, "2063"... | 11271123 | Endometrial cancer is associated with numeric and structural chromosomal abnormalities, microsatellite instability (MSI), and alterations that activate oncogenes and inactivate tumor suppressor genes. The aim of this study was to characterize a set of endometrial cancers using multiple molecular genetic and immunohisto... | Molecular characterization of endometrial cancer: a correlative study assessing microsatellite instability, MLH1 hypermethylation, DNA mismatch repair protein expression, and PTEN, PIK3CA, KRAS, and BRAF mutation analysis. |
{"1011": 0.2539152204990387, "1017": 0.15777134895324707, "1045": 0.3910386264324188, "1052": 0.6086184978485107, "1062": 0.5272908806800842, "1156": 0.7482418417930603, "1999": 0.04394211992621422, "2000": 0.02316705882549286, "2003": 0.043007105588912964, "2005": 0.1401015669107437, "2011": 0.3750596046447754, "2016"... | 11280569 | Plant resistance against the necrotrophic pathogen Plectosphaerella cucumerina is mediated by a combination of several hormonal-controlled signalling pathways. The priming agent β-aminobutyric acid (BABA) is able to induce effective resistance against this pathogen by stimulating callose-rich cell wall depositions. In ... | Identification of indole-3-carboxylic acid as mediator of priming against Plectosphaerella cucumerina. |
{"1011": 0.319873183965683, "1054": 0.04487626627087593, "2000": 0.056018441915512085, "2004": 0.6950984001159668, "2022": 0.018384648486971855, "2028": 0.10906458646059036, "2047": 0.23787821829319, "2057": 0.23556606471538544, "2060": 0.04860413447022438, "2089": 0.38174858689308167, "2090": 0.28670501708984375, "210... | 11288846 | Randomized trials may be designed and interpreted as single experiments or they may be seen in the context of other similar or relevant evidence. The amount and complexity of available randomized evidence vary for different topics. Systematic reviews may be useful in identifying gaps in the existing randomized evidence... | Evaluation of networks of randomized trials. |
{"1011": 0.004870930220931768, "1015": 0.0842406153678894, "1038": 0.3723714053630829, "1048": 0.3416208028793335, "1052": 0.1946154683828354, "1056": 0.4770587682723999, "2007": 0.4286321699619293, "2011": 0.0913962796330452, "2013": 0.06246116757392883, "2025": 0.05046287178993225, "2026": 0.6931471824645996, "2029":... | 11289247 | The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC) self-renewal and differentiation is not fully understood. Here we report that depletion of PTPMT1, a PTEN-like mitochondrial phosphatase, in inducible or hematopoietic-cell-specific knockout mice resulted in hematopoietic fai... | Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. |
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