spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.31845372915267944, "1015": 0.18654440343379974, "1017": 0.32270604372024536, "1020": 0.1401015669107437, "1038": 0.5849615335464478, "1042": 0.6714286804199219, "1043": 0.15442965924739838, "1049": 0.7086513638496399, "1052": 0.319873183965683, "1055": 0.10467668622732162, "1057": 0.42096930742263794, "1996"... | 11291348 | The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation an... | GSK-3-mediated phosphorylation enhances Maf-transforming activity. |
{"1011": 0.2145126610994339, "1020": 0.38041436672210693, "1022": 0.43244171142578125, "1051": 0.19541899859905243, "1054": 0.9005423784255981, "1155": 0.5495203733444214, "1999": 0.026025565341114998, "2007": 0.13157635927200317, "2011": 0.38174858689308167, "2013": 0.1905880719423294, "2015": 0.12986256182193756, "20... | 11328820 | The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune diseases display enhanced neutrophil extracellular trap (NET... | NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. |
{"1011": 0.2607102394104004, "1998": 0.040196798741817474, "2001": 0.06154331564903259, "2005": 0.16442140936851501, "2006": 0.6160298585891724, "2034": 0.49982786178588867, "2047": 0.2184450328350067, "2059": 0.012615402229130268, "2060": 0.22937409579753876, "2062": 0.3588210940361023, "2064": 0.083342544734478, "207... | 11335781 | The emergence of immuno-oncology as the first broadly successful strategy for metastatic cancer will require clinicians to integrate this new pillar of medicine with chemotherapy, radiation, and targeted small-molecule compounds. Of equal importance is gaining an understanding of the limitations and toxicities of immun... | Is autoimmunity the Achilles' heel of cancer immunotherapy? |
{"1011": 0.24171993136405945, "1017": 0.2689530849456787, "1038": 0.6512666940689087, "1043": 0.4855078160762787, "1044": 0.2689530849456787, "1055": 0.015504186972975731, "1999": 0.46914875507354736, "2002": 1.3123366832733154, "2010": 0.12556517124176025, "2011": 0.3262358605861664, "2013": 0.2837681770324707, "2015"... | 11335860 | Pluripotent human embryonic stem (hES) cells can differentiate into various cell types derived from the three embryonic germ layers and extraembryonic tissues such as trophoblasts. The mechanisms governing lineage choices of hES cells are largely unknown. Here, we report that we established two independent hES cell clo... | Trophoblast differentiation defect in human embryonic stem cells lacking PIG-A and GPI-anchored cell-surface proteins. |
{"1044": 1.0271050930023193, "1055": 0.05694137513637543, "1999": 0.010684899985790253, "2002": 0.3191637098789215, "2005": 0.18654440343379974, "2008": 0.10467668622732162, "2011": 0.15610189735889435, "2029": 0.16690383851528168, "2046": 0.014542185701429844, "2057": 0.5278670787811279, "2075": 0.06246116757392883, "... | 11336632 | Horizontal gene transfer (HGT) in bacteria and archaea occurs through phage transduction, transformation, or conjugation, and the latter is particularly important for the spread of antibiotic resistance. Clustered, regularly interspaced, short palindromic repeat (CRISPR) loci confer sequence-directed immunity against p... | CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA |
{"1039": 0.016465263441205025, "1040": 0.33605360984802246, "1041": 0.500420093536377, "1048": 0.2409527748823166, "1999": 0.2447827309370041, "2007": 0.012615402229130268, "2012": 0.15943801403045654, "2013": 0.15442965924739838, "2026": 0.7370892763137817, "2035": 0.6739205718040466, "2039": 0.02316705882549286, "204... | 11344428 | Leukemia in donor cells (donor cell leukemia; DCL) has been reported as a rare but severe complication of allogeneic stem cell transplantation (SCT). However, the incidence, potential pathogenetic factors, therapeutic options and outcome of patients suffering from DCL and the leukemia risk of their donors are not well ... | Development of leukemia in donor cells after allogeneic stem cell transplantation--a survey of the European Group for Blood and Marrow Transplantation (EBMT). |
{"1008": 0.1685553640127182, "1039": 0.9425065517425537, "1046": 0.32341301441192627, "1058": 0.21372433006763458, "2001": 0.11604541540145874, "2007": 0.42225050926208496, "2011": 0.1970241367816925, "2013": 0.4425300657749176, "2018": 0.16524957120418549, "2020": 0.2018241584300995, "2042": 0.1751343309879303, "2043"... | 11349166 | BACKGROUND Since 2004, several reported transfusion transmissions of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom have reawakened concerns about the possible risk of similar transmissions of nonvariant or classic forms of CJD. STUDY DESIGN AND METHODS Patients with a CJD diagnosis and a history of don... | Lack of evidence of transfusion transmission of Creutzfeldt-Jakob disease in a US surveillance study. |
{"1038": 0.7528522610664368, "1041": 0.9455460906028748, "1044": 0.1970241367816925, "1048": 0.22392450273036957, "2006": 0.4412745535373688, "2011": 0.2447827309370041, "2013": 0.11256109178066254, "2014": 0.803087055683136, "2020": 0.01934296265244484, "2029": 0.06795065850019455, "2033": 0.3676496744155884, "2034": ... | 11359243 | Altered DNA methylation occurs ubiquitously in human cancer from the earliest measurable stages. A cogent approach to understanding the mechanism and timing of altered DNA methylation is to analyze it in the context of carcinogenesis by a defined agent. Epstein-Barr virus (EBV) is a human oncogenic herpesvirus associat... | Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization. |
{"1996": 0.21372433006763458, "2004": 0.029824240133166313, "2008": 0.0606246218085289, "2011": 0.0029254043474793434, "2013": 0.0752234235405922, "2037": 0.05694137513637543, "2039": 0.42353010177612305, "2054": 0.03925827145576477, "2073": 0.11256109178066254, "2076": 0.14095009863376617, "2079": 0.4938860833644867, ... | 11360430 | Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem ce... | Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. |
{"1014": 0.472198486328125, "1040": 0.22937409579753876, "1043": 0.29400965571403503, "1998": 0.2089812457561493, "2004": 0.06612417846918106, "2064": 0.06337817758321762, "2076": 0.5822374224662781, "2077": 0.16110190749168396, "2090": 0.14264501631259918, "2141": 0.3963087201118469, "2151": 0.18004031479358673, "2172... | 11360768 | OBJECTIVE To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes. DESIGN Systematic review and meta-analysis. DATA SOURCES Major databases from inception to January 2012 without language restrictio... | Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence |
{"1017": 0.5696102976799011, "1039": 0.23324857652187347, "1048": 0.2763880789279938, "1049": 0.3034266233444214, "1999": 0.014542185701429844, "2003": 0.23324857652187347, "2005": 0.22782009840011597, "2006": 0.6186635494232178, "2026": 0.9256220459938049, "2029": 0.22157983481884003, "2033": 0.14095009863376617, "205... | 11369420 | Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the R... | Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia. |
{"1011": 0.12470348179340363, "1017": 0.18167030811309814, "1018": 0.21530038118362427, "1051": 0.04674193635582924, "1062": 0.7647408246994019, "1998": 0.23787821829319, "2003": 0.045809537172317505, "2011": 0.1734936386346817, "2029": 0.33675122261047363, "2047": 0.1994270235300064, "2048": 0.500420093536377, "2058":... | 11390393 | Naive and primed pluripotency is characterized by distinct signaling requirements, transcriptomes, and developmental properties, but both cellular states share key transcriptional regulators: Oct4, Sox2, and Nanog. Here, we demonstrate that transition between these two pluripotent states is associated with widespread O... | Reorganization of enhancer patterns in transition from naive to primed pluripotency. |
{"1011": 0.10906458646059036, "1015": 0.20022670924663544, "1016": 0.176772341132164, "1045": 0.42225050926208496, "1997": 0.0797421783208847, "1999": 0.0058422754518687725, "2001": 0.02316705882549286, "2002": 0.6170841455459595, "2004": 0.10731173306703568, "2007": 0.07159364968538284, "2013": 0.17759032547473907, "2... | 11401602 | The effects of topoisomerases I and II on the replication of SV40 DNA were examined using an in vitro replication system of purified proteins that constitutes the monopolymerase system. In the presence of the two topoisomerases, two distinct nascent DNAs were formed. One product arising from the replication of the lead... | Topoisomerase II plays an essential role as a swivelase in the late stage of SV40 chromosome replication in vitro. |
{"1011": 0.20739519596099854, "1043": 0.2983669638633728, "1045": 0.16276304423809052, "1058": 0.1970241367816925, "1999": 0.1064341589808464, "2003": 0.16524957120418549, "2006": 0.08064348995685577, "2007": 0.07068414986133575, "2010": 0.2719337046146393, "2011": 0.35745587944984436, "2029": 0.018384648486971855, "20... | 11411060 | Trypanosoma brucei, the causative agent of African sleeping sickness, is transmitted to its mammalian host by the tsetse. In the fly, the parasite's surface is covered with invariant procyclin, while in the mammal it resides extracellularly in its bloodstream form (BF) and is densely covered with highly immunogenic Var... | Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome |
{"1011": 0.2478361576795578, "1015": 0.7408206462860107, "1041": 0.1905880719423294, "1043": 0.2622140049934387, "1045": 0.9500881433486938, "1996": 0.38174858689308167, "1998": 0.09317722171545029, "1999": 0.0038986403960734606, "2015": 0.10906458646059036, "2028": 0.3824150264263153, "2029": 0.23633737862110138, "204... | 11414664 | The insulin/IGF-1 (where IGF-1 is insulin-like growth factor-1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We... | Timing requirements for insulin/IGF-1 signaling in C. elegans. |
{"1009": 0.47827014327049255, "1011": 0.10906458646059036, "1015": 0.28597161173820496, "1048": 0.42225050926208496, "1050": 0.09406650811433792, "1056": 0.28963330388069153, "1157": 0.684319257736206, "2003": 0.02792670577764511, "2004": 0.10731173306703568, "2007": 0.05694137513637543, "2013": 0.026976587250828743, "... | 11415809 | OBJECTIVES Non-celiac wheat sensitivity (NCWS) is defined as a reaction to ingested wheat after exclusion of celiac disease and wheat allergy. As its pathogenesis is incompletely understood, we evaluated the inflammatory response in the rectal mucosa of patients with well-defined NCWS. METHODS The prospective study inc... | Predominance of Type 1 Innate Lymphoid Cells in the Rectal Mucosa of Patients With Non-Celiac Wheat Sensitivity: Reversal After a Wheat-Free Diet |
{"1011": 0.2501201331615448, "1039": 0.13670019805431366, "1041": 0.5718178153038025, "1043": 0.5267143249511719, "1996": 0.25694093108177185, "1997": 0.3870677351951599, "1999": 0.20022670924663544, "2006": 0.04113444685935974, "2011": 0.2105647772550583, "2013": 0.11256109178066254, "2015": 0.3560888469219208, "2024"... | 11419230 | We propose a concept for the folding and self-assembly of the pore-forming TatA complex from the Twin-arginine translocase and of other membrane proteins based on electrostatic "charge zippers. " Each subunit of TatA consists of a transmembrane segment, an amphiphilic helix (APH), and a C-terminal densely charged regio... | Folding and Self-Assembly of the TatA Translocation Pore Based on a Charge Zipper Mechanism |
{"1009": 0.417115718126297, "1011": 0.21372433006763458, "1015": 0.28743788599967957, "1042": 0.8340972661972046, "1056": 0.5381823778152466, "1996": 0.02792670577764511, "1997": 0.016465263441205025, "2004": 0.05786345899105072, "2005": 0.175953671336174, "2007": 0.1510767638683319, "2008": 0.05694137513637543, "2011"... | 11420613 | The 137 ribosomal protein genes (RPGs) of Saccharomyces provide a model for gene coregulation. We examined the positional and functional organization of their regulators (Rap1 [repressor activator protein 1], Fhl1, Ifh1, Sfp1, and Hmo1), the transcription machinery (TFIIB, TFIID, and RNA polymerase II), and chromatin a... | Molecular mechanisms of ribosomal protein gene coregulation. |
{"1011": 0.022212404757738113, "1052": 0.49030399322509766, "1996": 0.0913962796330452, "2003": 0.2837681770324707, "2011": 0.0842406153678894, "2029": 0.16607704758644104, "2050": 0.11081436276435852, "2063": 0.1946154683828354, "2080": 0.7182208299636841, "2106": 0.02887592278420925, "2152": 0.09228714555501938, "216... | 11428884 | Adipose tissue is an important metabolic organ, the dysfunction of which is associated with the development of obesity, diabetes mellitus, and cardiovascular disease. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is considered the master regulator of adipocyte differentiation and functio... | Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ. |
{"1003": 0.22859740257263184, "1014": 0.3084607720375061, "1026": 0.14095009863376617, "1039": 0.16359257698059082, "1042": 0.10906458646059036, "1043": 0.29255300760269165, "1052": 0.5010119676589966, "1062": 0.04860413447022438, "2004": 0.24248650670051575, "2005": 0.07884006202220917, "2011": 0.026976587250828743, "... | 11441172 | PURPOSE OF REVIEW Owing to the high mortality, risk of neurodevelopmental impairment and end-organ involvement with fungal infections in the neonate, prevention of invasive Candida infections in extremely preterm infants should be a priority for each neonatal ICU. RECENT FINDINGS Even with prompt or empiric treatment, ... | Fluconazole prophylaxis: can we eliminate invasive Candida infections in the neonatal ICU? |
{"1040": 0.35745587944984436, "1042": 0.2689530849456787, "1047": 0.672426164150238, "2002": 0.272677481174469, "2003": 0.4318077862262726, "2063": 0.43434104323387146, "2099": 0.22859740257263184, "2135": 0.4537591338157654, "2155": 0.5290185213088989, "2229": 0.0842406153678894, "2271": 0.0029254043474793434, "2389":... | 11457219 | Fumarase deficiency is a rare autosomal recessive inborn error of metabolism of the Krebs Tricarboxylic Acid cycle. A heavy neurological disease burden is imparted by fumarase deficiency, commonly manifesting as microcephaly, dystonia, global developmental delay, seizures, and lethality in the infantile period. Heteroz... | Fumarase deficiency in dichorionic diamniotic twins. |
{"1011": 0.6338034868240356, "1014": 0.08244366943836212, "1016": 0.8357921838760376, "1020": 0.22157983481884003, "1052": 0.11691460013389587, "1054": 0.9455460906028748, "1059": 0.6970458030700684, "1999": 0.053244512528181076, "2003": 0.06795065850019455, "2007": 0.1718502640724182, "2011": 0.16276304423809052, "202... | 11459139 | INTRODUCTION Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytosis, and bioavailabili... | Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity |
{"1011": 0.04953393340110779, "1041": 0.24631060659885406, "2004": 0.16607704758644104, "2011": 0.04767346754670143, "2064": 0.15943801403045654, "2069": 0.04487626627087593, "2084": 0.1930064558982849, "2092": 0.2105647772550583, "2107": 0.05046287178993225, "2109": 0.45499902963638306, "2138": 0.037378571927547455, "... | 11469078 | A number of authors have attempted to defend ecologic (aggregate) studies by claiming that the goal of those studies is estimation of ecologic (contextual or group-level) effects rather than individual-level effects. Critics of these attempts point out that ecologic effect estimates are inevitably used as estimates of ... | Ecologic versus individual-level sources of bias in ecologic estimates of contextual health effects. |
{"1011": 0.28890204429626465, "1996": 0.4770587682723999, "1998": 0.1930064558982849, "2004": 0.7454653382301331, "2006": 0.052318159490823746, "2011": 0.21293537318706512, "2029": 0.1358480453491211, "2031": 0.10203468054533005, "2043": 0.2470736801624298, "2045": 0.2990913391113281, "2048": 0.08603433519601822, "2049... | 11475379 | Although vertebrates seem to be essentially bilaterally symmetrical on the exterior, there are numerous interior left–right asymmetries in the disposition and placement of internal organs. These asymmetries are established during embryogenesis by complex epigenetic and genetic cascades. Recent studies in a range of mod... | Left–right asymmetry in the vertebrate embryo: from early information to higher-level integration |
{"1016": 0.966567873954773, "1023": 0.01934296265244484, "1044": 0.021256839856505394, "1045": 0.6999598741531372, "1056": 0.8109301924705505, "1998": 0.28450319170951843, "2005": 0.1685553640127182, "2007": 0.21687394380569458, "2045": 0.010684899985790253, "2048": 0.7009293437004089, "2058": 0.4158279001712799, "2064... | 11481946 | Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsulinemia, increased levels of IGF, elevated levels of steroid and peptide hormones, and inflammatory markers appear to play a role i... | Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. |
{"1011": 0.22937409579753876, "1040": 0.04394211992621422, "1050": 0.22392450273036957, "1061": 0.33953672647476196, "2003": 0.021256839856505394, "2004": 0.043007105588912964, "2005": 0.304147332906723, "2015": 0.6128603219985962, "2024": 0.16110190749168396, "2025": 0.20977331697940826, "2029": 0.026976587250828743, ... | 11484808 | A significant fraction of the human genome is transcribed as non-coding RNAs (ncRNAs). This non-coding transcriptome has challenged the notion of the central dogma and its involvement in transcriptional and post-transcriptional regulation of gene expression is well established. Interestingly, several ncRNAs are dysregu... | Non-coding RNAs: Functions and applications in endocrine-related cancer. |
{"1011": 0.5016035437583923, "1013": 0.14939609169960022, "1050": 0.09761575609445572, "1997": 0.06612417846918106, "1998": 0.4914994537830353, "2004": 0.1946154683828354, "2007": 0.6512666940689087, "2025": 0.014542185701429844, "2028": 0.19381128251552582, "2048": 0.5027855634689331, "2053": 0.574020504951477, "2064"... | 11498670 | Nonspecific protein-DNA interactions are inherently dynamic and involve both diffusion of the protein along the DNA and hopping of the protein from one DNA molecule or segment to another. Understanding how gene regulatory proteins interact nonspecifically with DNA in terms of both structure and dynamics is challenging ... | NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. |
{"1011": 0.25845035910606384, "1043": 0.6989894509315491, "1044": 0.9108069539070129, "1049": 0.9987343549728394, "2002": 0.29981520771980286, "2005": 0.2145126610994339, "2008": 0.0038986403960734606, "2010": 0.8400169610977173, "2015": 0.052318159490823746, "2025": 0.2786078155040741, "2029": 0.19862671196460724, "20... | 11527199 | Background Current criteria for the selection of unrelated donors for hematopoietic cell transplantation (HCT) include matching for the alleles of each human leukocyte antigen (HLA) locus within the major histocompatibility complex (MHC). Graft-versus-host disease (GVHD), however, remains a significant and potentially... | MHC Haplotype Matching for Unrelated Hematopoietic Cell Transplantation |
{"1016": 0.1970241367816925, "1017": 0.2837681770324707, "1018": 0.22704219818115234, "1042": 0.37974658608436584, "1056": 0.053244512528181076, "1996": 0.11430477350950241, "2003": 0.037378571927547455, "2011": 0.28597161173820496, "2024": 0.05417001247406006, "2029": 0.1946154683828354, "2054": 0.009718249551951885, ... | 11527822 | The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining. The short life span of a sir3 or sir4 mutant is due to the simultaneous expression of a and alpha mating-type information, which indire... | The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13 |
{"1014": 0.05046287178993225, "1038": 0.9386941194534302, "1043": 0.5045560002326965, "1052": 0.037378571927547455, "1053": 0.306306391954422, "1055": 0.4831010699272156, "1056": 0.04767346754670143, "2007": 0.1946154683828354, "2012": 0.043007105588912964, "2013": 0.21135559678077698, "2015": 0.16607704758644104, "202... | 11532028 | Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was fo... | Meta-analysis identifies common variants associated with body mass index in East Asians |
{"1011": 0.06154331564903259, "1017": 0.1619328260421753, "1020": 0.08064348995685577, "1022": 0.3877306580543518, "1040": 0.10993985831737518, "1044": 0.7144040465354919, "1055": 0.42735910415649414, "1056": 0.5936289429664612, "1996": 0.28450319170951843, "1997": 0.1718502640724182, "1999": 0.15693697333335876, "2002... | 11532659 | Nucleosomes, the fundamental units of chromatin structure, are regulators and barriers to transcription, replication and repair. Post-translational modifications (PTMs) of the histone proteins within nucleosomes regulate these DNA processes. Histone H3(T118) is a site of phosphorylation [H3(T118ph)] and is implicated i... | Phosphorylation of histone H3(T118) alters nucleosome dynamics and remodeling |
{"1011": 0.06154331564903259, "1059": 0.3381449282169342, "1061": 0.7239188551902771, "1156": 0.3810817003250122, "2003": 0.0009760859538801014, "2004": 0.020300358533859253, "2011": 0.38174858689308167, "2012": 0.27564704418182373, "2029": 0.10203468054533005, "2033": 0.5133614540100098, "2036": 0.15359249711036682, "... | 11535539 | Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog of drosophila Yki) and transc... | Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. |
{"1011": 0.02887592278420925, "1017": 0.036437395960092545, "1041": 0.1677299439907074, "1048": 0.9500881433486938, "1054": 0.32129061222076416, "1060": 0.8633513450622559, "1155": 0.4425300657749176, "2003": 0.3269403576850891, "2008": 0.06520967930555344, "2011": 0.3409265875816345, "2012": 0.21687394380569458, "2079... | 11557602 | LXR alpha is a nuclear receptor that has previously been shown to regulate the metabolic conversion of cholesterol to bile acids. Here we define a role for this transcription factor in the control of cellular cholesterol efflux. We demonstrate that retroviral expression of LXR alpha in NIH 3T3 fibroblasts or RAW264.7 m... | Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. |
{"1011": 0.12986256182193756, "1043": 0.8525851964950562, "1054": 0.9680526852607727, "1996": 0.37640097737312317, "2011": 0.33953672647476196, "2012": 0.1602703034877777, "2029": 0.2317005842924118, "2051": 0.6405166387557983, "2072": 0.3127557039260864, "2073": 0.13243216276168823, "2076": 0.23247487843036652, "2078"... | 11565780 | Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are coordinated by precisely timed cell-cell communication, the principle of which is largely unknown. Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to ina... | Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus |
{"1011": 0.27934664487838745, "1015": 0.6527929902076721, "1038": 0.13670019805431366, "1998": 0.18492233753204346, "1999": 0.06337817758321762, "2003": 0.11691460013389587, "2004": 0.5347557663917542, "2005": 0.1221139207482338, "2007": 0.28450319170951843, "2008": 0.11778303235769272, "2011": 0.33953672647476196, "20... | 11568270 | Human TopBP1 is a major player in the control of the DNA replication checkpoint. In this study, we identified MDC1, a key checkpoint protein involved in the cellular response to DNA double-strand breaks, as a TopBP1-associated protein. The specific TopBP1-MDC1 interaction is mediated by the fifth BRCT domain of TopBP1 ... | MDC1 collaborates with TopBP1 in DNA replication checkpoint control |
{"1040": 0.6862877607345581, "1052": 0.6950984001159668, "1155": 0.12556517124176025, "1156": 1.3049486875534058, "1157": 0.29400965571403503, "2003": 0.13499516248703003, "2008": 0.13071982562541962, "2011": 0.2696990668773651, "2029": 0.27934664487838745, "2046": 0.36967599391937256, "2058": 0.6970458030700684, "2071... | 11569583 | DNA polymerase β (Pol β) is an error-prone enzyme which has been found to be overexpressed in several human tumors. By using a couple of recombinant CHO cells differing only from the exogenous expression of Pol β, we showed here that cells overexpressing Pol β are much more sensitive to IR treatments by increasing apop... | Deregulated DNA polymerase β strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities |
{"1011": 0.16607704758644104, "1021": 0.6265231370925903, "1043": 0.6563454270362854, "1051": 0.3077431619167328, "1060": 0.5957841277122498, "2003": 0.1485546976327896, "2011": 0.056018441915512085, "2024": 0.09672962874174118, "2073": 0.02316705882549286, "2090": 0.06977381557226181, "2152": 0.5584990978240967, "2155... | 11578459 | BACKGROUND HOX genes are a family of developmental genes that are expressed neither in the developing forebrain nor in the normal brain. Aberrant expression of a HOX-gene dominated stem-cell signature in glioblastoma has been linked with increased resistance to chemo-radiotherapy and sustained proliferation of glioma i... | Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma |
{"1044": 0.5301685929298401, "1999": 0.5517725944519043, "2001": 0.13670019805431366, "2010": 0.7380234599113464, "2020": 0.09317722171545029, "2029": 0.11517547070980072, "2031": 0.1011524572968483, "2038": 0.016465263441205025, "2070": 0.1619328260421753, "2076": 0.022212404757738113, "2080": 0.75193190574646, "2093"... | 11581157 | The invertebrate's innate immune system was reported to show some form of adaptive features, termed trained immunity. However, the memory characteristics of innate immune system and the mechanisms behind such phenomena remain unclear. Using the invertebrate model Artemia, we verified the possibility or impossibility of... | Probing the phenomenon of trained immunity in invertebrates during a transgenerational study, using brine shrimp Artemia as a model system |
{"1006": 0.07159364968538284, "1011": 0.42096930742263794, "1016": 0.6704301834106445, "1017": 0.47766464948654175, "1020": 0.46853771805763245, "1052": 0.6911921501159668, "1997": 0.026976587250828743, "1998": 0.0317181795835495, "1999": 0.13071982562541962, "2002": 0.24325250089168549, "2005": 0.18816383183002472, "2... | 11603066 | Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions within... | Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex |
{"1014": 0.08064348995685577, "1021": 0.1930064558982849, "1052": 0.3519764244556427, "1058": 0.4002431631088257, "2005": 0.35334911942481995, "2007": 0.34715715050697327, "2043": 0.020300358533859253, "2044": 0.3170322775840759, "2051": 0.2830325961112976, "2053": 0.4450363218784332, "2078": 0.2786078155040741, "2086"... | 11614737 | IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE To determine efficacy and safety of varenicline and bupropion sustained-release (SR; combination therapy) compared with varenicline (monotherapy) in cigarette smokers. DESIGN, SETTING, AND PARTICIPANTS Ran... | Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial. |
{"1011": 0.29619070887565613, "1013": 0.31132611632347107, "1017": 0.36494144797325134, "1039": 0.630689799785614, "1041": 0.5290185213088989, "1043": 0.469759464263916, "1048": 0.35334911942481995, "1156": 0.1332872211933136, "1998": 0.16110190749168396, "1999": 0.11168810725212097, "2005": 0.32553088665008545, "2007"... | 11615242 | CCAAT/enhancer-binding proteins, C/EBPalpha and C/EBPbeta, are required for fat cell differentiation and maturation. Previous studies showed that replacement of C/EBPalpha with C/EBPbeta, generating the beta/beta alleles in the mouse genome, prevents lipid accumulation in white adipose tissue (WAT). In this study, beta... | Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. |
{"1017": 0.004870930220931768, "1019": 0.39893341064453125, "1021": 0.08871890604496002, "1023": 0.5472630262374878, "1038": 0.5925496220588684, "1041": 0.4770587682723999, "1048": 0.3982778787612915, "1052": 0.41389304399490356, "1060": 0.23015019297599792, "2005": 0.058784693479537964, "2007": 0.02412080205976963, "2... | 11615422 | The search for target genes involved in unbalanced acquired chromosomal abnormalities has been largely unsuccessful, because the breakpoints of these rearrangements are too variable. Here, we use the example of dicentric chromosomes in B cell precursor acute lymphoblastic leukemia to show that, despite this heterogenei... | Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer. |
{"1011": 0.03266380727291107, "1040": 0.03360854089260101, "1043": 0.6613984704017639, "1044": 0.8083226680755615, "1048": 0.24859806895256042, "1999": 0.09938567131757736, "2003": 0.07068414986133575, "2004": 0.0029254043474793434, "2007": 0.31132611632347107, "2011": 0.40351006388664246, "2015": 0.7809720039367676, "... | 11616424 | Hypoglycemia is among the most injurious metabolic disorders caused by endotoxemia. In experimental endotoxemia with lipopolysaccharide (LPS) in animals, a marked glucose consumption is observed in macrophage-rich organs. However, the direct effect of LPS on the uptake of glucose by macrophages has not been fully under... | Copyright � 1996, American Society for Microbiology Endotoxin-Induced Enhancement of Glucose Influx into |
{"1003": 0.1332872211933136, "1014": 0.2026219218969345, "1038": 0.2447827309370041, "1043": 0.45623743534088135, "1051": 0.09584271162748337, "2011": 0.0354953333735466, "2022": 0.5751199722290039, "2034": 0.319873183965683, "2035": 0.0317181795835495, "2062": 0.11865071207284927, "2082": 0.77198725938797, "2084": 0.0... | 11624482 | CONTEXT Certification by an American Board of Medical Specialties (ABMS) member board is emerging as a measure of physician quality. OBJECTIVE To identify demographic and educational factors associated with ABMS member board certification of US medical school graduates. DESIGN, SETTING, AND PARTICIPANTS Retrospective s... | Factors associated with American Board of Medical Specialties member board certification among US medical school graduates. |
{"1014": 0.33675122261047363, "1023": 0.14264501631259918, "1038": 0.7881022095680237, "1046": 0.034552380442619324, "1997": 0.004870930220931768, "2004": 0.0797421783208847, "2012": 0.21765978634357452, "2058": 0.4374985992908478, "2062": 0.08871890604496002, "2084": 0.3423145115375519, "2086": 0.29981520771980286, "2... | 11630388 | BACKGROUND Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial. METHODS We examined the association between body weight and the risk of death in a 12-year prospective cohort study of 1,213,829 Koreans between the ages of 30 and 95 years. We exami... | Body-mass index and mortality in Korean men and women. |
{"1011": 0.10026945173740387, "1037": 0.14095009863376617, "1055": 0.013579257763922215, "1999": 0.013579257763922215, "2008": 0.03360854089260101, "2015": 0.417115718126297, "2029": 0.24325250089168549, "2037": 0.058784693479537964, "2061": 0.8433839678764343, "2064": 0.3409265875816345, "2067": 0.20102575421333313, "... | 11659421 | Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing aging-related features in human iPSC-derived lineages and apply it to the mo... | Human iPSC-based modeling of late-onset disease via progerin-induced aging. |
{"1011": 0.007782140281051397, "1055": 1.004473328590393, "1996": 0.04113444685935974, "1999": 0.055094651877880096, "2001": 0.23479416966438293, "2003": 0.09850110858678818, "2005": 0.18654440343379974, "2008": 0.1751343309879303, "2011": 0.06977381557226181, "2015": 0.4425300657749176, "2024": 0.2447827309370041, "20... | 11661377 | Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as key components of protein complexes that drive membrane fusion. Despite considerable sequence divergence among SNARE proteins, their mechanism seems to be conserved and is adaptable for fusion reactions as diverse as those involved ... | SNAREs — engines for membrane fusion |
{"1011": 0.35677260160446167, "1049": 0.7352184057235718, "1056": 1.190008521080017, "1996": 0.13157635927200317, "1997": 0.0009760859538801014, "1998": 0.18816383183002472, "2011": 0.2478361576795578, "2029": 0.31560876965522766, "2038": 0.018384648486971855, "2048": 0.04113444685935974, "2079": 0.015504186972975731, ... | 11666252 | The persistence of naive and memory T cells has long been of interest to immunologists, but the factors that influence the survival and homeostasis of these subsets have remained obscure. In recent years, it has become evident that the homeostasis of both naive and memory T-cell pools is highly dynamic and tightly regu... | Maintaining the norm: T-cell homeostasis |
{"1011": 0.036437395960092545, "2011": 0.006812678650021553, "2013": 0.5662899017333984, "2015": 0.5936289429664612, "2026": 0.5033760666847229, "2029": 0.14264501631259918, "2042": 0.06337817758321762, "2046": 0.3409265875816345, "2061": 0.7755908370018005, "2066": 0.07793712615966797, "2071": 0.2652147710323334, "208... | 11674288 | Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here we show that iPSCs obtained from mouse fibroblasts, hematopoie... | Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells |
{"1047": 0.7124901413917542, "1056": 0.8534175157546997, "1996": 0.18978065252304077, "2008": 0.08064348995685577, "2012": 0.12556517124176025, "2029": 0.3283478021621704, "2063": 0.37304413318634033, "2076": 0.4158279001712799, "2079": 0.11168810725212097, "2099": 0.3870677351951599, "2105": 0.21530038118362427, "2229... | 11674596 | A putative spindle matrix has been hypothesized to mediate chromosome motion, but its existence and functionality remain controversial. In this report, we show that Megator (Mtor), the Drosophila melanogaster counterpart of the human nuclear pore complex protein translocated promoter region (Tpr), and the spindle assem... | Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator |
{"1013": 0.10818854719400406, "1014": 0.4500300884246826, "1015": 0.1384023278951645, "1019": 0.09050461649894714, "1020": 0.18329764902591705, "1022": 0.5110208988189697, "1040": 0.5696102976799011, "1042": 0.9980146884918213, "1048": 0.25995752215385437, "2000": 0.08692999184131622, "2005": 0.06154331564903259, "2007... | 11705328 | BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevant to food fortification) is unclear. METHODS We randomized 151 patients with is... | Randomized trial of folic acid supplementation and serum homocysteine levels. |
{"1996": 0.17431432008743286, "2003": 0.0354953333735466, "2008": 0.053244512528181076, "2015": 0.07884006202220917, "2024": 0.14433705806732178, "2029": 0.18978065252304077, "2037": 0.1212492436170578, "2076": 0.6634125709533691, "2078": 0.45251765847206116, "2079": 0.304147332906723, "2081": 0.06520967930555344, "209... | 11710511 | Adherens junctions and their core molecular components, classic cadherins, make major contributions to animal morphogenesis. Although the significance of cadherins in development is generally accepted, the mechanisms regulating adherens junction function during morphogenesis remain a subject of intense research. Adhere... | Adherens junctions in Drosophila retinal morphogenesis. |
{"1015": 0.021256839856505394, "1018": 0.04953393340110779, "1020": 0.29473719000816345, "1021": 0.2026219218969345, "1038": 0.6223390698432922, "1040": 0.5313173532485962, "1041": 0.3353555500507355, "1042": 0.6327666640281677, "1043": 0.4248080551624298, "1045": 0.3297532796859741, "1051": 0.12556517124176025, "1056"... | 11716783 | Publisher Summary This chapter discusses the developmental roles of vascular endothelial growth factor (VEGF) in skeletal morphogenesis, speculates on the future directions of research in this area, and describes some of the challenges in the field. VEGF regulates osteoclastic differentiation, migration, and activity. ... | Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair. |
{"1014": 0.30486753582954407, "1038": 0.0009760859538801014, "1040": 0.8247235417366028, "1043": 1.0478670597076416, "1052": 0.021256839856505394, "1058": 0.3339579105377197, "1998": 0.09761575609445572, "2000": 0.0058422754518687725, "2004": 0.5098485946655273, "2005": 0.1212492436170578, "2007": 0.259204238653183, "2... | 11718220 | BACKGROUND Deep vein thrombosis (DVT) and pulmonary embolism are common after stroke. In small trials of patients undergoing surgery, graduated compression stockings (GCS) reduce the risk of DVT. National stroke guidelines extrapolating from these trials recommend their use in patients with stroke despite insufficient ... | Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial |
{"1011": 0.07793712615966797, "1014": 0.6118015646934509, "1019": 0.23015019297599792, "1022": 0.10379679501056671, "1038": 0.5662899017333984, "1044": 0.4487839937210083, "1046": 0.4248080551624298, "1052": 0.8989537954330444, "1053": 0.7076893448829651, "2007": 0.5534584522247314, "2012": 0.2493593990802765, "2013": ... | 11721286 | BACKGROUND Streptococcus pneumoniae infection starts from colonization of the host respiratory tract where interaction with host respiratory tract epithelial cells occurs. To investigate pneumococcal genes that are involved in the early stage of interaction with host epithelial cells, transcriptional responses of an en... | Streptococcus pneumoniae early response genes to human lung epithelial cells |
{"1011": 0.0752234235405922, "1019": 0.040196798741817474, "1020": 0.11081436276435852, "1038": 0.2786078155040741, "1039": 0.37371641397476196, "1047": 0.4818955361843109, "1048": 0.17922431230545044, "1059": 0.0029254043474793434, "1996": 0.26146242022514343, "1999": 0.0770333781838417, "2001": 0.02887592278420925, "... | 11721676 | Primary afferent fibers are originated from pseudounipolar sensory cells in dorsal root ganglia (DRG) and transmit external stimuli received in the skin to the spinal cord. Here we undertook a proteomic approach to uncover the polarity of primary afferent fibers. Lumbar spinal nerve segments, peripheral and central to ... | Proteomic identification of a novel isoform of collapsin response mediator protein-2 in spinal nerves peripheral to dorsal root ganglia. |
{"1011": 0.2990913391113281, "1013": 0.11778303235769272, "1042": 0.21922965347766876, "1052": 0.02792670577764511, "1997": 0.029824240133166313, "1999": 0.03266380727291107, "2013": 0.06520967930555344, "2029": 0.036437395960092545, "2050": 1.0271050930023193, "2064": 0.16359257698059082, "2075": 0.06886265426874161, ... | 11728637 | The FASTA package of sequence comparison programs has been modified to provide accurate statistical estimates for local sequence similarity scores with gaps. These estimates are derived using the extreme value distribution from the mean and variance of the local similarity scores of unrelated sequences after the scores... | Empirical statistical estimates for sequence similarity searches |
{"1021": 0.11604541540145874, "1022": 0.23556606471538544, "1023": 0.40546512603759766, "1039": 0.567397952079773, "1040": 0.7827593088150024, "1052": 0.45437926054000854, "1158": 0.41389304399490356, "1998": 0.04860413447022438, "2029": 0.09584271162748337, "2054": 0.20102575421333313, "2076": 0.1685553640127182, "207... | 11738716 | Dietary restriction (DR) increases healthspan and longevity in many species, including primates, but it is often accompanied by impaired reproductive function. Whether signals associated with the reproductive system contribute to or are required for DR effects on lifespan has not been established. Here we show that exp... | Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans. |
{"1043": 0.012615402229130268, "1044": 0.4849066734313965, "1061": 0.5528968572616577, "1998": 0.022212404757738113, "1999": 0.15275461971759796, "2003": 0.1485546976327896, "2005": 0.012615402229130268, "2011": 0.2696990668773651, "2029": 0.2317005842924118, "2039": 0.14264501631259918, "2054": 0.1677299439907074, "20... | 11742219 | Galanin (GAL) is known to stimulate feeding behavior. This peptide has different properties and functions from other feeding stimulants, e.g., neuropeptide Y and agouti-related protein. Hypothalamic GAL is relatively unresponsive to food deprivation and to changes in corticosterone, glucose utilization, dietary carbohy... | Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis. |
{"1003": 0.025073638185858727, "1997": 0.17267228662967682, "1998": 0.20022670924663544, "2000": 0.13157635927200317, "2038": 0.10291612148284912, "2039": 0.5729197263717651, "2042": 0.2659635543823242, "2055": 0.06977381557226181, "2057": 0.2576959431171417, "2064": 0.3982778787612915, "2065": 0.2478361576795578, "207... | 11748341 | Maternal undernutrition contributes to 800,000 neonatal deaths annually through small for gestational age births; stunting, wasting, and micronutrient deficiencies are estimated to underlie nearly 3·1 million child deaths annually. Progress has been made with many interventions implemented at scale and the evidence for... | Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? |
{"1011": 0.37371641397476196, "1021": 0.16442140936851501, "1041": 0.2447827309370041, "1042": 1.0409941673278809, "1043": 0.11865071207284927, "1056": 0.77198725938797, "1156": 0.43623676896095276, "2011": 0.25467249751091003, "2029": 0.1401015669107437, "2033": 0.6244332790374756, "2076": 0.10731173306703568, "2079":... | 11771811 | Maintenance of normal endothelial function is critical to various aspects of blood vessel function, but its regulation is poorly understood. In this study, we show that disruption of baseline fibroblast growth factor (FGF) signaling to the endothelium leads to a dramatic reduction in let-7 miRNA levels that, in turn, i... | FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. |
{"1040": 0.8100618124008179, "1054": 0.9857001900672913, "1060": 0.9929623603820801, "2005": 0.16110190749168396, "2008": 0.02887592278420925, "2024": 0.013579257763922215, "2029": 0.15860503911972046, "2099": 0.9827804565429688, "2121": 0.24018502235412598, "2128": 0.8366385698318481, "2170": 0.1401015669107437, "2179... | 11774598 | Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan rec... | Nuclear Receptors, RXR, and the Big Bang |
{"1011": 0.11865071207284927, "1015": 0.6176109313964844, "1056": 0.6808650493621826, "2000": 0.058784693479537964, "2002": 0.890972912311554, "2005": 0.25845035910606384, "2008": 0.13071982562541962, "2011": 0.27044451236724854, "2015": 0.34577593207359314, "2025": 0.1905880719423294, "2028": 0.23864774405956268, "202... | 11784947 | Short interfering RNAs (siRNAs) have been used to inhibit HIV-1 replication. The durable inhibition of HIV-1 replication by RNA interference has been impeded, however, by a high mutation rate when viral sequences are targeted and by cytotoxicity when cellular genes are knocked down. To identify cellular proteins that c... | A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. |
{"1011": 0.1970241367816925, "1054": 0.16276304423809052, "1060": 1.0841858386993408, "1061": 0.10026945173740387, "1996": 0.18004031479358673, "2002": 0.5021947622299194, "2003": 0.3743882179260254, "2015": 0.15693697333335876, "2029": 0.16690383851528168, "2048": 0.04674193635582924, "2063": 0.5640701055526733, "2075... | 11822354 | Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of th... | UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. |
{"1038": 0.8989537954330444, "1048": 1.0108904838562012, "1056": 0.5381823778152466, "2003": 0.09495500475168228, "2011": 0.11168810725212097, "2015": 0.02792670577764511, "2029": 0.06246116757392883, "2033": 0.5936289429664612, "2050": 0.27044451236724854, "2058": 0.4431571960449219, "2099": 0.7638313174247742, "2157"... | 11831598 | Bistability in developmental pathways refers to the generation of binary outputs from graded or noisy inputs. Signaling thresholds are critical for bistability. Specification of the left/right (LR) axis in vertebrate embryos involves bistable expression of transforming growth factor beta (TGFbeta) member NODAL in the l... | BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. |
{"1011": 0.015504186972975731, "1015": 0.011650617234408855, "1020": 0.45251765847206116, "1038": 0.7863243818283081, "1044": 0.3777405619621277, "1052": 0.1751343309879303, "1999": 0.04394211992621422, "2011": 0.3346569836139679, "2012": 0.2231435477733612, "2026": 1.0815403461456299, "2029": 0.05970508232712746, "206... | 11837657 | Mycobacterium tuberculosis (Mtb) infects lung macrophages, which instead of killing the pathogen can be manipulated by the bacilli, creating an environment suitable for intracellular replication and spread to adjacent cells. The role of host cell death during Mtb infection is debated because the bacilli have been shown... | Human Macrophages Infected with a High Burden of ESAT-6-Expressing M. tuberculosis Undergo Caspase-1- and Cathepsin B-Independent Necrosis |
{"1011": 0.26296505331993103, "1055": 0.05970508232712746, "1066": 0.07159364968538284, "1998": 0.06977381557226181, "2000": 0.015504186972975731, "2007": 0.1011524572968483, "2013": 0.19541899859905243, "2022": 0.013579257763922215, "2026": 0.0752234235405922, "2029": 0.11951763927936554, "2046": 0.5963221788406372, "... | 11840194 | Conventional protocols for differentiating human induced-pluripotent stem cells (hiPSCs) into smooth-muscle cells (SMCs) can be inefficient and generally fail to yield cells with a specific SMC phenotype (i.e., contractile or synthetic SMCs). Here, we present two novel hiPSC-SMC differentiation protocols that yield SMC... | Differentiation of Human Induced-Pluripotent Stem Cells into Smooth-Muscle Cells: Two Novel Protocols |
{"1011": 0.29619070887565613, "1015": 0.10026945173740387, "1018": 0.15943801403045654, "1044": 0.7969439625740051, "1062": 0.9147270321846008, "1996": 0.00875066313892603, "1998": 0.11430477350950241, "1999": 0.08692999184131622, "2002": 0.12986256182193756, "2007": 0.018384648486971855, "2008": 0.043007105588912964, ... | 11844791 | Boundary elements hinder the spread of heterochromatin, yet these sites do not fully account for the preservation of adjacent euchromatin. Histone variant H2A.Z (Htz1 in yeast) replaces conventional H2A in many nucleosomes. Microarray analysis revealed that HTZ1-activated genes cluster near telomeres. The reduced expre... | Conserved Histone Variant H2A.Z Protects Euchromatin from the Ectopic Spread of Silent Heterochromatin |
{"1011": 0.35128939151763916, "1015": 0.6684301495552063, "1047": 0.1913948506116867, "1050": 1.0437490940093994, "1054": 0.7182208299636841, "1164": 0.6170841455459595, "2003": 0.3297532796859741, "2006": 0.24325250089168549, "2008": 0.21687394380569458, "2011": 0.3297532796859741, "2028": 0.2696990668773651, "2029": ... | 11844826 | MURR1 is a multifunctional protein that inhibits nuclear factor kappaB (NF-kappaB), a transcription factor with pleiotropic functions affecting innate and adaptive immunity, apoptosis, cell cycle regulation, and oncogenesis. Here we report the discovery of a new family of proteins with homology to MURR1. These proteins... | COMMD proteins, a novel family of structural and functional homologs of MURR1. |
{"1019": 0.07793712615966797, "1023": 0.9409833550453186, "1040": 0.15023678541183472, "1042": 0.029824240133166313, "1052": 0.7951818704605103, "1999": 0.37974658608436584, "2006": 0.10203468054533005, "2007": 0.037378571927547455, "2013": 0.0174254160374403, "2020": 0.08961215615272522, "2029": 0.014542185701429844, ... | 11861374 | To define the genetic changes of flat urothelial lesions, carcinoma in situ (CIS) and moderate dysplasias (DII) were investigated for alterations in the two chromosomal regions most frequently involved in bladder cancer. Overall, 33 CIS and 16 DII from 21 patients were used to microdissect urothelium. Dual color fluore... | Occurrence of chromosome 9 and p53 alterations in multifocal dysplasia and carcinoma in situ of human urinary bladder |
{"1021": 0.010684899985790253, "1023": 0.38574060797691345, "1048": 0.08782484382390976, "1052": 0.5393219590187073, "1054": 0.4041621685028076, "1997": 0.10379679501056671, "1999": 0.2160874605178833, "2005": 0.1619328260421753, "2012": 0.06795065850019455, "2013": 0.16524957120418549, "2038": 0.08692999184131622, "20... | 11862753 | Ractopamine hydrochloride (RAC) has consistently led to an advantage in carcass cutting yields of finishing pigs and remains a common feed additive in US finishing pig diets. Less is known about the effect of RAC on further processing characteristics. Some researchers have reported advantages in ultimate pH of the LM i... | Fresh meat and further processing characteristics of ham muscles from finishing pigs fed ractopamine hydrochloride. |
{"1039": 0.5415972471237183, "1041": 0.055094651877880096, "1042": 0.058784693479537964, "1999": 0.17267228662967682, "2003": 0.22782009840011597, "2011": 0.2105647772550583, "2013": 0.2184450328350067, "2015": 0.06246116757392883, "2054": 0.29255300760269165, "2110": 0.37974658608436584, "2152": 0.0174254160374403, "2... | 11868606 | Cystic Fibrosis (CF) is an inherited pleiotropic disease that results from abnormalities in the gene codes of a chloride channel. The lungs of CF patients are chronically infected by several pathogens but bacteraemia have rarely been reported in this pathology. Besides that, circulating monocytes in CF patients exhibit... | Translocated LPS Might Cause Endotoxin Tolerance in Circulating Monocytes of Cystic Fibrosis Patients |
{"1014": 0.5186077356338501, "1022": 0.07431721687316895, "2001": 0.129004567861557, "2004": 0.04113444685935974, "2011": 0.011650617234408855, "2020": 0.15023678541183472, "2022": 0.05046287178993225, "2034": 0.06886265426874161, "2035": 0.0913962796330452, "2039": 0.319873183965683, "2042": 0.24171993136405945, "2043... | 11880289 | BACKGROUND Age-specific effects of mammographic screening, and the timing of such effects, are a matter of debate. The results of the UK Age trial, which compared the effect of invitation to annual mammographic screening from age 40 years with commencement of screening at age 50 years on breast cancer mortality, have b... | Effect of mammographic screening from age 40 years on breast cancer mortality in the UK Age trial at 17 years' follow-up: a randomised controlled trial. |
{"1011": 0.12642613053321838, "1014": 0.07250232994556427, "1040": 0.6853039860725403, "1044": 0.6950984001159668, "1049": 0.757441520690918, "1062": 0.6773988008499146, "2002": 0.11778303235769272, "2004": 0.23247487843036652, "2014": 0.4624064862728119, "2020": 0.1384023278951645, "2035": 0.2711893916130066, "2043": ... | 11884292 | BACKGROUND AND AIMS We adopted the twin method to disentangle the genetic and environmental components of susceptibility to coeliac disease (CD). We estimated disease concordance rate by zygosity and HLA genotypes, discordance times, progression rates to disease, and heritability. METHODS We crosslinked the Italian Twi... | Concordance, disease progression, and heritability of coeliac disease in Italian twins. |
{"1059": 0.1221139207482338, "2005": 0.0606246218085289, "2045": 0.32129061222076416, "2064": 0.3353555500507355, "2071": 0.05786345899105072, "2078": 1.223315715789795, "2079": 0.02792670577764511, "2109": 0.6086184978485107, "2142": 0.018384648486971855, "2181": 0.6286086440086365, "2217": 0.0797421783208847, "2224":... | 11884867 | Electro-magnetic fields and wireless technology are part of modern life. The use of Magnetic Resonance Imaging (MRI) machines for clarification of internal human structures and function in healthcare is increasing. The rapid development of wireless devices, their miniaturization and their application as clinical tools ... | A literature review of the safety of medical body area network devices in magnetic resonance imaging |
{"1020": 0.0029254043474793434, "1043": 0.75193190574646, "1044": 0.5313173532485962, "1058": 0.8517522215843201, "1996": 0.2837681770324707, "1998": 0.15275461971759796, "1999": 0.23015019297599792, "2005": 0.004870930220931768, "2008": 0.00875066313892603, "2029": 0.304147332906723, "2031": 0.04767346754670143, "2039... | 11886686 | The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate and VGAT for GABA) are required for ves... | Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. |
{"1011": 0.5086748600006104, "1039": 1.0855059623718262, "1047": 0.28670501708984375, "1054": 0.14179791510105133, "1999": 0.08064348995685577, "2006": 0.8298473954200745, "2029": 0.3683255612850189, "2038": 0.037378571927547455, "2058": 0.28450319170951843, "2063": 0.16276304423809052, "2079": 0.15860503911972046, "20... | 11887584 | The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic. These observations have raised doubts about the involvement of c-src in the etiology of human tumors. However, recent studies have shown that c-Src, a non-receptor tyrosine kinase, exhibits e... | c-Src and cooperating partners in human cancer. |
{"1009": 0.7647408246994019, "1011": 0.37102460861206055, "1015": 0.6223390698432922, "1016": 0.6233867406845093, "1017": 0.14602625370025635, "1018": 0.2539152204990387, "1039": 0.10379679501056671, "1056": 0.9515975713729858, "2007": 0.05046287178993225, "2011": 0.18167030811309814, "2013": 0.02412080205976963, "2028... | 11899391 | Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared with nondiseased, control individuals. Treg dysfunction cou... | Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function. |
{"1011": 0.3409265875816345, "1016": 0.5393219590187073, "1019": 0.4462870955467224, "1039": 0.14095009863376617, "1059": 0.1718502640724182, "2000": 0.026025565341114998, "2007": 0.13071982562541962, "2011": 0.5540198087692261, "2029": 0.03925827145576477, "2037": 0.23710809648036957, "2039": 0.20501139760017395, "204... | 11900630 | Objective. Chemotherapeutic agents function by inducing apoptosis and their effectiveness depends on the balance of pro- and anti-apoptotic proteins in cells. Due to the complicated interactions of the many proteins involved, it has been difficult to determine in tumors whether overexpression of single genes is prognos... | Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2. |
{"1017": 0.3070250153541565, "1037": 0.10993985831737518, "1040": 0.21922965347766876, "1048": 0.8821197748184204, "1996": 0.5186077356338501, "1999": 0.00875066313892603, "2003": 0.35128939151763916, "2011": 0.3269403576850891, "2024": 0.20421554148197174, "2026": 0.9317949414253235, "2029": 0.056018441915512085, "206... | 11902109 | The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in mammals, proliferate and differentiate into three types of mature cell--plasmatocytes, crystal cells and lamellocytes--the functions of which are reminiscent of mammalian myeloid cells... | Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila |
{"1040": 0.24631060659885406, "1041": 0.30917787551879883, "1052": 0.8893690705299377, "1057": 0.43623676896095276, "2011": 0.015504186972975731, "2029": 0.24325250089168549, "2064": 0.34922540187835693, "2076": 0.2317005842924118, "2079": 0.026976587250828743, "2083": 0.13499516248703003, "2091": 0.20580662786960602, ... | 11903247 | Multiple cellular stressors, including activation of the tumour suppressor p53, can stimulate autophagy. Here we show that deletion, depletion or inhibition of p53 can induce autophagy in human, mouse and nematode cells subjected to knockout, knockdown or pharmacological inhibition of p53. Enhanced autophagy improved t... | Regulation of autophagy by cytoplasmic p53 |
{"1044": 0.07793712615966797, "1054": 0.06612417846918106, "1996": 0.4932899475097656, "1997": 0.22548456490039825, "1999": 0.02412080205976963, "2007": 0.018384648486971855, "2011": 0.18654440343379974, "2029": 0.17431432008743286, "2033": 0.46914875507354736, "2049": 0.13755162060260773, "2073": 0.24325250089168549, ... | 11913139 | To appreciate the neural underpinnings of sleep, it is important to view this universal mammalian behaviour at multiple levels of its biological organization. Molecularly, the circadian rhythm of sleep involves interlocking positive- and negative-feedback mechanisms of circadian genes and their protein products in cell... | The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks |
{"1009": 0.26820653676986694, "1017": 0.4196864068508148, "1040": 0.7528522610664368, "2005": 0.07793712615966797, "2011": 0.16276304423809052, "2025": 0.304147332906723, "2029": 0.18411032855510712, "2033": 0.24018502235412598, "2034": 0.2539152204990387, "2041": 0.08782484382390976, "2044": 0.3106105625629425, "2053"... | 11915280 | Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we demonstrate that the loss of Dnmt3b has no impact on microadenoma forma... | Suppression of intestinal neoplasia by deletion of Dnmt3b |
{"1011": 0.0354953333735466, "1020": 0.12470348179340363, "1048": 0.29400965571403503, "1055": 0.436867892742157, "1056": 0.956112265586853, "1156": 0.5483922958374023, "1996": 0.41065993905067444, "1999": 0.4938860833644867, "2011": 0.17922431230545044, "2015": 0.007782140281051397, "2029": 0.14095009863376617, "2034"... | 11921405 | The gut mucosal epithelium separates the host from the microbiota, but enteropathogens such as Salmonella Typhimurium (S.Tm) can invade and breach this barrier. Defenses against such acute insults remain incompletely understood. Using a murine model of Salmonella enterocolitis, we analyzed mechanisms limiting pathogen ... | Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. |
{"1011": 0.15023678541183472, "1015": 0.4926934838294983, "1060": 0.8989537954330444, "1999": 0.009718249551951885, "2005": 0.2674594223499298, "2007": 0.28963330388069153, "2008": 0.03925827145576477, "2011": 0.31560876965522766, "2028": 0.25694093108177185, "2029": 0.3248254358768463, "2061": 0.4450363218784332, "207... | 11922370 | Many of the factors required for chromosomal DNA replication have been identified in unicellular eukaryotes. However, DNA replication is poorly understood in multicellular organisms. Here, we report the identification of GEMC1 (geminin coiled-coil containing protein 1), a novel vertebrate protein required for chromosom... | GEMC1 is a TopBP1 interacting protein required for chromosomal DNA replication |
{"2005": 0.03925827145576477, "2007": 0.08692999184131622, "2039": 0.020300358533859253, "2043": 0.11081436276435852, "2044": 0.7987030148506165, "2048": 0.004870930220931768, "2051": 0.3601844012737274, "2052": 0.1510767638683319, "2053": 0.06886265426874161, "2064": 0.371698260307312, "2065": 0.009718249551951885, "2... | 11933721 | UNLABELLED Biomechanical studies suggest a suture bridge technique enhances rotator cuff tendon footprint contact area, holding strength, and mean contact pressure. Based on these studies, we asked whether (1) the suture bridge technique would provide a high rate of cuff integrity after surgery, (2) the status of the r... | Does an arthroscopic suture bridge technique maintain repair integrity?: a serial evaluation by ultrasonography. |
{"1011": 0.04674193635582924, "1020": 0.2317005842924118, "1021": 0.2837681770324707, "1039": 0.45251765847206116, "1043": 0.009718249551951885, "1044": 0.27786844968795776, "1052": 0.3241194784641266, "1999": 0.053244512528181076, "2029": 0.09761575609445572, "2033": 0.0606246218085289, "2060": 0.14179791510105133, "2... | 11935250 | Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may be a risk factor for human colon cancer. It is not known whether this age-related DNA methylation phenomenon is specific to human tissues. We p... | Widespread and tissue specific age-related DNA methylation changes in mice. |
{"1003": 0.03831886500120163, "1997": 0.1212492436170578, "2003": 0.4437839686870575, "2012": 0.02316705882549286, "2038": 0.11951763927936554, "2042": 0.12642613053321838, "2054": 0.3963087201118469, "2057": 0.06246116757392883, "2058": 0.24171993136405945, "2062": 0.04953393340110779, "2075": 0.018384648486971855, "2... | 11936877 | Soil erosion is a major environmental threat to the sustainability and productive capacity of agriculture. During the last 40 years, nearly one-third of the world's arable land has been lost by erosion and continues to be lost at a rate of more than 10 million hectares per year. With the addition of a quarter of a mill... | Environmental and economic costs of soil erosion and conservation benefits. |
{"1014": 0.3656192123889923, "1052": 0.5238267183303833, "1054": 0.06886265426874161, "2001": 0.053244512528181076, "2005": 0.007782140281051397, "2012": 0.4151833653450012, "2015": 0.5180262327194214, "2020": 0.012615402229130268, "2035": 0.27044451236724854, "2039": 0.34922540187835693, "2042": 0.004870930220931768, ... | 11939159 | IMPORTANCE Among nontraditional cardiovascular risk factors, recent influenzalike infection is associated with fatal and nonfatal atherothrombotic events. OBJECTIVES To determine if influenza vaccination is associated with prevention of cardiovascular events. DATA SOURCES AND STUDY SELECTION A systematic review and met... | Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis. |
{"1010": 0.08692999184131622, "1017": 0.14433705806732178, "1019": 0.22001366317272186, "1020": 0.35334911942481995, "1021": 0.39367714524269104, "1038": 0.1889725625514984, "1996": 0.021256839856505394, "2001": 0.11430477350950241, "2013": 0.1734936386346817, "2020": 0.27342069149017334, "2028": 0.07250232994556427, "... | 11943989 | The "ba, ba, ba" sound universal to babies' babbling around 7 months captures scientific attention because it provides insights into the mechanisms underlying language acquisition and vestiges of its evolutionary origins. Yet the prevailing mystery is what is the biological basis of babbling, with one hypothesis being ... | Baby hands that move to the rhythm of language: hearing babies acquiring sign languages babble silently on the hands |
{"1011": 0.23092569410800934, "1016": 0.44753631949424744, "1019": 0.1485546976327896, "1040": 0.12556517124176025, "1043": 0.02887592278420925, "1048": 0.33115679025650024, "1050": 0.151916041970253, "1056": 0.46608972549438477, "1156": 0.3325583338737488, "2003": 0.045809537172317505, "2004": 0.4624064862728119, "201... | 11951999 | Ten-Eleven Translocation-2 (TET2) inactivation through loss-of-function mutation, deletion and IDH1/2 (Isocitrate Dehydrogenase 1 and 2) gene mutation is a common event in myeloid and lymphoid malignancies. TET2 gene mutations similar to those observed in myeloid and lymphoid malignancies also accumulate with age in ot... | The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases |
{"1014": 0.46608972549438477, "1015": 0.777387797832489, "1019": 0.010684899985790253, "1020": 0.13243216276168823, "1044": 0.7389566898345947, "1050": 0.11343330889940262, "1052": 0.4349733293056488, "1997": 0.06795065850019455, "2001": 0.14349138736724854, "2004": 0.41195443272590637, "2007": 0.11343330889940262, "20... | 11953232 | OBJECTIVE To determine the prevalence and clinical associations of impaired awareness of hypoglycemia in a population-based sample of children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS A validated questionnaire was administered to 656 patients with type 1 diabetes over a 6-month period to determ... | Impaired Awareness of Hypoglycemia in a Population-Based Sample of Children and Adolescents With Type 1 Diabetes |
{"1020": 0.38174858689308167, "1038": 0.49030399322509766, "1040": 0.36967599391937256, "1043": 0.006812678650021553, "1055": 0.49626702070236206, "2005": 0.5415972471237183, "2011": 0.3683255612850189, "2025": 0.0058422754518687725, "2029": 0.10467668622732162, "2051": 0.37907835841178894, "2063": 0.1619328260421753, ... | 11968641 | BACKGROUND Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation, we compared growth and cell cycle events of B16 melanoma cells and tumors with either a functional... | Enhancing circadian clock function in cancer cells inhibits tumor growth |
{"1011": 0.14939609169960022, "1020": 0.026025565341114998, "1040": 0.9546096324920654, "1052": 0.7445381283760071, "1061": 0.030771657824516296, "1996": 0.1510767638683319, "1997": 0.06246116757392883, "1999": 0.026025565341114998, "2003": 0.2576959431171417, "2005": 0.0009760859538801014, "2008": 0.15860503911972046,... | 11983390 | Cytoplasmic dynein is a microtubule-based motor protein that is responsible for most intracellular retrograde transports along microtubule filaments. The motor domain of dynein contains six tandemly linked AAA (ATPases associated with diverse cellular activities) modules, with the first four containing predicted nucleo... | Distinct functions of nucleotide-binding/hydrolysis sites in the four AAA modules of cytoplasmic dynein. |
{"1011": 0.2741633653640747, "1015": 0.15359249711036682, "1040": 0.056018441915512085, "1056": 0.7951818704605103, "2007": 0.1994270235300064, "2012": 0.17267228662967682, "2015": 0.2478361576795578, "2029": 0.14095009863376617, "2058": 0.4654768109321594, "2072": 0.4002431631088257, "2078": 0.8169882297515869, "2091"... | 11992632 | People with Down syndrome (DS) exhibit abnormal brain structure. Alterations affecting neurotransmission and signalling pathways that govern brain function are also evident. A large number of genes are simultaneously expressed at abnormal levels in DS; therefore, it is a challenge to determine which gene(s) contribute ... | Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory. |
{"1014": 0.3499138653278351, "1018": 0.2394166737794876, "1022": 0.06612417846918106, "1039": 0.8829278349876404, "1041": 1.034767985343933, "1045": 0.0019512200960889459, "1052": 0.2696990668773651, "1998": 0.10467668622732162, "2005": 0.15359249711036682, "2015": 0.306306391954422, "2029": 0.07431721687316895, "2034"... | 12009265 | CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer, and vitamins E and C are among the most common individual supplements. A large-scale randomized trial suggested that vitamin E may reduce risk of prostate cancer; however, few trials have been powered to address this rela... | Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. |
{"1056": 0.4752389192581177, "1996": 0.1064341589808464, "2005": 0.07250232994556427, "2008": 0.06977381557226181, "2015": 0.3141832649707794, "2022": 0.11951763927936554, "2025": 0.6862877607345581, "2053": 0.10467668622732162, "2057": 0.040196798741817474, "2060": 0.39367714524269104, "2078": 0.036437395960092545, "2... | 12014458 | We propose that the microRNA milieu, unique to each cell type, productively dampens the expression of thousands of mRNAs and provides important context for the evolution of all metazoan mRNA sequences. For genes that should not be expressed in a particular cell type, protein output is lowered to inconsequential levels.... | Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs |
{"1998": 0.29619070887565613, "2004": 0.29255300760269165, "2028": 0.18411032855510712, "2029": 0.17922431230545044, "2035": 0.42161011695861816, "2057": 0.04394211992621422, "2072": 1.068206787109375, "2073": 0.05970508232712746, "2075": 0.3910386264324188, "2076": 0.42225050926208496, "2079": 0.015504186972975731, "2... | 12030318 | Morphogenesis and pattern formation are vital processes in any organism, whether unicellular or multicellular. But in contrast to the developmental biology of plants and animals, the principles of morphogenesis and pattern formation in single cells remain largely unknown. Although all cells develop patterns, they are m... | The Kinase Regulator Mob1 Acts as a Patterning Protein for Stentor Morphogenesis |
{"1038": 0.5957841277122498, "1048": 0.46486347913742065, "1054": 0.026025565341114998, "1056": 0.7647408246994019, "2005": 0.04860413447022438, "2011": 0.2034190446138382, "2013": 0.25088030099868774, "2064": 0.3560888469219208, "2071": 0.06520967930555344, "2079": 0.12556517124176025, "2094": 0.1384023278951645, "209... | 12030680 | The complex repertoire of immune receptors generated by B and T cells enables recognition of diverse threats to the host organism. In this work, we show that massively parallel DNA sequencing of rearranged immune receptor loci can provide direct detection and tracking of immune diversity and expanded clonal lymphocyte ... | Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. |
{"1003": 0.06612417846918106, "1014": 0.09584271162748337, "1017": 0.056018441915512085, "1039": 0.26446542143821716, "1055": 0.08064348995685577, "2015": 0.6699305176734924, "2043": 0.04113444685935974, "2055": 0.014542185701429844, "2058": 0.004870930220931768, "2062": 0.19622190296649933, "2086": 0.4337083101272583,... | 12030735 | OBJECTIVE Limited information is available about the metabolic syndrome in Asians. Furthermore, the definition of central obesity using waist circumference may not be appropriate for Asians. The objectives of this study were to determine the optimal waist circumference for diagnosing central obesity in Asians and to es... | Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians? |
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