spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
|---|---|---|---|
{"1014": 0.15526613593101501, "1019": 0.45994341373443604, "1020": 0.17759032547473907, "1021": 0.16607704758644104, "1042": 0.018384648486971855, "1999": 0.1485546976327896, "2003": 0.23556606471538544, "2004": 0.01934296265244484, "2006": 0.1064341589808464, "2012": 0.01934296265244484, "2029": 0.09050461649894714, "... | 12039953 | Depression is a mood disorder characterized by complex alterations of neurotransmitters such as serotonin, norepinephrine, and dopamine. In particular, there is substantial evidence of abnormalities in serotonin neurotransmission. Peripheral parameters of serotoninergic transmission, such as the 5-hydroxytryptamine con... | Serotonin and fluoxetine levels in plasma and platelets after fluoxetine treatment in depressive patients. |
{"1011": 0.04394211992621422, "1041": 0.5734702348709106, "1044": 0.24018502235412598, "1059": 0.22782009840011597, "2005": 0.08782484382390976, "2007": 0.151916041970253, "2008": 0.034552380442619324, "2010": 0.8100618124008179, "2011": 0.1693800985813141, "2029": 0.2786078155040741, "2031": 0.05139094591140747, "2038... | 12040627 | Pluripotent embryonic stem cells (ESCs) maintain self-renewal and the potential for rapid response to differentiation cues. Both ESC features are subject to epigenetic regulation. Here we show that the histone acetyltransferase Mof plays an essential role in the maintenance of ESC self-renewal and pluripotency. ESCs wi... | The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network. |
{"1009": 0.2531573474407196, "1011": 0.3910386264324188, "1014": 0.1905880719423294, "1015": 0.43053874373435974, "1018": 0.43434104323387146, "1019": 0.12642613053321838, "1020": 0.27342069149017334, "1023": 0.12038381397724152, "1039": 1.0236024856567383, "1048": 0.2089812457561493, "1060": 0.4228905141353607, "1996"... | 12058271 | The bone marrow is the primary site for neutrophil production and release into the circulation. Because the CXC chemokine receptor-4/stromal derived factor-1 (CXCR4/SDF-1) axis plays a central role in the interactions of hematopoietic stem cells, lymphocytes, and developing neutrophils in the marrow, we investigated wh... | Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. |
{"1011": 0.025073638185858727, "1014": 0.22548456490039825, "1026": 0.04394211992621422, "1040": 1.261651873588562, "1044": 0.04394211992621422, "1048": 0.043007105588912964, "1052": 0.21530038118362427, "1998": 0.06612417846918106, "2022": 0.04674193635582924, "2064": 0.02887592278420925, "2078": 0.10993985831737518, ... | 12074066 | BACKGROUND Inadequate photosynthesis or oral intake of Vitamin D are associated with high incidence rates of colorectal cancer, but the dose-response relationship has not been adequately studied. METHODS Dose-response gradients from observational studies of Vitamin D intake and serum 25-hydroxyvitamin D were plotted as... | Vitamin D and prevention of colorectal cancer. |
{"1011": 0.10379679501056671, "1042": 0.5887627601623535, "1054": 0.11168810725212097, "1997": 0.053244512528181076, "2004": 0.8349450826644897, "2008": 0.04113444685935974, "2010": 0.7473171949386597, "2011": 0.31845372915267944, "2024": 0.014542185701429844, "2025": 0.27044451236724854, "2029": 0.13414156436920166, "... | 12086599 | Major eukaryotic genomic elements, including the ribosomal DNA (rDNA), are composed of repeated sequences with well-defined copy numbers that must be maintained by regulated recombination. Although mechanisms that instigate rDNA recombination have been identified, none are directional and they therefore cannot explain ... | Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery |
{"1019": 0.09406650811433792, "1039": 0.5506471395492554, "1041": 0.37907835841178894, "1043": 0.5278670787811279, "1996": 0.11430477350950241, "1999": 0.10906458646059036, "2002": 0.5381823778152466, "2008": 0.04207121208310127, "2011": 0.010684899985790253, "2025": 0.05139094591140747, "2029": 0.1905880719423294, "20... | 12086818 | Multiple extracellular factors are hypothesized to promote the differentiation of unstimulated and/or stimulated secretory pathways in exocrine secretory cells, but the identity of differentiation factors, particularly those organ-specific, remain largely unknown. Here, we report on the identification of a novel secret... | cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. |
{"1998": 0.0174254160374403, "2001": 0.1619328260421753, "2043": 0.21135559678077698, "2045": 0.3560888469219208, "2058": 0.18654440343379974, "2062": 0.13157635927200317, "2095": 0.2667117714881897, "2106": 0.22859740257263184, "2108": 0.14349138736724854, "2111": 0.4950772523880005, "2116": 0.5690577030181885, "2120"... | 12087063 | This study investigated whether there are race differences in the structure of informal caregiving networks. Data on 3,793 functionally impaired persons age 65 and over from the 1989 National Long-Term Care Survey were analyzed. The size of the total caregiver network and the unpaid network did not differ by race, but ... | The structure of informal care: are there differences by race? |
{"1011": 0.1212492436170578, "1017": 0.3588210940361023, "1023": 0.2317005842924118, "1044": 0.5330380201339722, "1999": 0.06429435312747955, "2007": 0.32270604372024536, "2008": 0.05046287178993225, "2010": 0.8877626657485962, "2011": 0.38374659419059753, "2015": 0.38041436672210693, "2029": 0.42353010177612305, "2033... | 12100854 | Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) involves a marked reorganization of chromatin. To identify post-translational histone modifications that change in global abundance during this process, we have applied a quantitative mass-spectrometry-based approach. We found that iPSCs, compar... | Proteomic and genomic approaches reveal critical functions of H3K9 methylation and Heterochromatin Protein-1γ in reprogramming to pluripotency |
{"1011": 0.08064348995685577, "1021": 0.11604541540145874, "1022": 0.6461620330810547, "1037": 0.5162794589996338, "1039": 0.052318159490823746, "1041": 0.5795059204101562, "1056": 1.133164644241333, "2011": 0.45251765847206116, "2013": 0.4145384132862091, "2029": 0.02316705882549286, "2034": 0.22626367211341858, "2041... | 12100963 | Memory/effector T cells efficiently migrate into extralymphoid tissues and sites of infection, providing immunosurveillance and a first line of defense against invading pathogens. Even though it is a potential means to regulate the size, quality, and duration of a tissue infiltrate, T cell egress from infected tissues ... | Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung. |
{"1014": 0.5220900774002075, "1039": 0.10291612148284912, "1042": 0.06337817758321762, "1998": 0.020300358533859253, "2007": 0.013579257763922215, "2089": 0.10203468054533005, "2094": 0.6764062643051147, "2118": 0.3283478021621704, "2140": 0.2561853528022766, "2152": 0.6773988008499146, "2166": 0.20739519596099854, "21... | 12102963 | Objective: To assess the association of dietary flavonol intake with the subsequent risk of coronary heart disease (CHD) mortality. Design: Meta-analysis of prospective cohort studies published before September 2001. Studies were identified by MEDLINE and EMBASE searches and by scanning relevant reference lists. The fo... | The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies |
{"1011": 0.0029254043474793434, "1039": 0.053244512528181076, "1048": 0.8169882297515869, "1998": 0.17840765416622162, "2000": 0.18329764902591705, "2004": 0.10555581003427505, "2005": 0.13071982562541962, "2006": 0.4818955361843109, "2007": 0.3723714053630829, "2026": 0.659380316734314, "2029": 0.16359257698059082, "2... | 12122482 | We compared the diagnostic capabilities of MRI to CT, evoked potentials (EP), and CSF oligoclonal banding analysis in a prospective evaluation of 200 patients with suspected multiple sclerosis (MS). MRI was the best method for demonstrating dissemination in space. An abnormal appropriate EP in monosymptomatic disease w... | MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. |
{"1011": 0.1401015669107437, "1013": 0.2223619967699051, "1038": 0.7067264318466187, "1044": 0.11778303235769272, "1051": 1.102510929107666, "1996": 0.27342069149017334, "2002": 0.1808556467294693, "2011": 0.24171993136405945, "2029": 0.20977331697940826, "2033": 0.27342069149017334, "2073": 0.1905880719423294, "2080":... | 12130067 | Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. We used the oc/oc mouse, a mouse model with impaired endochondral ossification caused by a loss of osteoclast (OCL) activity, to investigate t... | Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow |
{"1006": 0.03266380727291107, "1009": 0.3883931338787079, "1014": 0.2983669638633728, "1019": 0.2881702482700348, "1020": 0.052318159490823746, "1022": 0.10993985831737518, "1041": 0.940220832824707, "1052": 0.6260011196136475, "1999": 0.8853482007980347, "2004": 0.5914691090583801, "2012": 0.1994270235300064, "2022": ... | 12130200 | OBJECTIVE To assess prospectively the risk of coronary heart disease associated with elevated plasma levels of homocyst(e)ine. DESIGN Nested case-control study using prospectively collected blood samples. SETTING Participants in the Physicians' Health Study. PARTICIPANTS A total of 14,916 male physicians, aged 40 to 84... | A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. |
{"1011": 0.6400018334388733, "1016": 1.034767985343933, "1043": 0.6160298585891724, "1048": 0.272677481174469, "1051": 0.6186635494232178, "1059": 0.28450319170951843, "2003": 0.16110190749168396, "2011": 0.22626367211341858, "2029": 0.15526613593101501, "2035": 0.33115679025650024, "2048": 0.5584990978240967, "2053": ... | 12130690 | Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor activated through proteolytic cleavage. It is localized on epithelial, endothelial and inflammatory cells, as well as on transient receptor potential vanilloid 1 (TRPV1) receptor-expressing neurones. It plays an important role in inflammatory/nocicep... | Involvement of transient receptor potential vanilloid 1 receptors in protease-activated receptor-2-induced joint inflammation and nociception. |
{"1003": 0.03831886500120163, "1015": 0.29981520771980286, "1026": 0.10906458646059036, "1042": 0.043007105588912964, "1053": 0.23479416966438293, "1058": 0.2607102394104004, "1998": 0.4518963396549225, "2007": 0.30989447236061096, "2025": 0.3588210940361023, "2028": 0.07612881064414978, "2031": 0.24554696679115295, "2... | 12145359 | BACKGROUND Individuals with severely impaired lung function have an increased risk of lung cancer. Whether milder reductions in forced expiratory volume in 1 second (FEV(1)) also increase the risk of lung cancer is controversial. Moreover, there is little consensus on whether men and women have similar risks for lung c... | Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis. |
{"1011": 0.2184450328350067, "1015": 0.3554046154022217, "1016": 0.022212404757738113, "1017": 0.08961215615272522, "1045": 0.8264343738555908, "1052": 0.5098485946655273, "1056": 0.08244366943836212, "1996": 0.1332872211933136, "1997": 0.1873544454574585, "2003": 0.03266380727291107, "2008": 0.08603433519601822, "2011... | 12149169 | Synthesis of ribosomal RNA (rRNA) by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. Here we report the 12 A cryo-electron microscopic structure for the complete 14-subunit yeast Pol I, a homology model for the core enzyme, and the crystal structure of ... | Functional Architecture of RNA Polymerase I |
{"1011": 0.151916041970253, "1013": 0.026976587250828743, "1015": 0.29255300760269165, "1043": 0.17267228662967682, "1055": 0.6317287683486938, "1999": 0.10203468054533005, "2005": 0.1930064558982849, "2008": 0.022212404757738113, "2028": 0.08064348995685577, "2029": 0.3325583338737488, "2039": 0.2607102394104004, "206... | 12152977 | The SWI/SNF-Brg1 chromatin remodeling protein plays critical roles in cell-cycle control and differentiation through regulation of gene expression. Loss of Brg1 in mice results in early embryonic lethality, and recent studies have implicated a role for Brg1 in somatic stem cell self-renewal and differentiation. However... | SWI/SNF-Brg1 regulates self-renewal and occupies core pluripotency-related genes in embryonic stem cells. |
{"1011": 0.13243216276168823, "1038": 0.48068851232528687, "1056": 0.5324648022651672, "2004": 0.8022117614746094, "2008": 0.037378571927547455, "2010": 0.8845420479774475, "2011": 0.4412745535373688, "2015": 0.009718249551951885, "2029": 0.3554046154022217, "2035": 0.11430477350950241, "2050": 0.26146242022514343, "20... | 12156187 | The mechanism of activation of the alternative lengthening of telomeres (ALT) pathway of mammalian chromosome-end maintenance has been unclear. We have now discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT in both primary and cancer cells. These included ... | Rapid induction of Alternative Lengthening of Telomeres by depletion of the histone chaperone ASF1 |
{"1011": 0.2786078155040741, "1048": 0.8608771562576294, "2003": 0.3297532796859741, "2005": 0.21372433006763458, "2006": 0.18573370575904846, "2024": 0.12986256182193756, "2064": 0.12470348179340363, "2071": 0.1751343309879303, "2079": 0.34023189544677734, "2100": 0.0606246218085289, "2109": 0.26146242022514343, "2140... | 12172346 | Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create docking sites for bromodomains, which are small interaction modules found on diverse proteins, some of which have a key role i... | Targeting bromodomains: epigenetic readers of lysine acetylation |
{"1009": 0.3547199070453644, "1019": 0.06612417846918106, "1020": 0.38441169261932373, "1022": 0.3134697377681732, "1023": 0.3554046154022217, "1041": 0.4450363218784332, "1047": 0.4337083101272583, "1052": 0.7592713832855225, "1999": 0.06886265426874161, "2004": 0.1229778528213501, "2007": 0.2018241584300995, "2008": ... | 12197393 | Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators. EETs produce vascular relaxation by activating smooth muscle large-conductance Ca2+-activated K+ channels (BKCa). In add... | Arachidonic acid cytochrome P450 epoxygenase pathway. |
{"1997": 0.1011524572968483, "1998": 0.16607704758644104, "1999": 0.10379679501056671, "2001": 0.08064348995685577, "2009": 0.2954642176628113, "2012": 0.3870677351951599, "2020": 0.4177590310573578, "2042": 0.19622190296649933, "2051": 0.23864774405956268, "2062": 0.48068851232528687, "2075": 0.14433705806732178, "207... | 12205576 | OBJECTIVE The aim was to describe the sex and socioeconomic differences in patterns of physical activity at work and in leisure time of men and women aged 36 years, and to investigate factors in childhood and adolescence which predict high rates of participation in sports and recreational activities in later life. DESI... | Physical activity at 36 years: patterns and childhood predictors in a longitudinal study. |
{"1003": 0.006812678650021553, "1016": 0.16524957120418549, "1044": 0.8957691192626953, "2001": 0.3077431619167328, "2020": 0.2561853528022766, "2039": 0.2247048318386078, "2042": 0.00875066313892603, "2043": 0.36358460783958435, "2051": 0.21293537318706512, "2058": 0.42608439922332764, "2084": 0.20580662786960602, "20... | 12206390 | CONTEXT The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown. OBJECTIVES To estimate the residual lifetime risk for hypertension in older US adults and to evaluate temporal trends in this risk. D... | Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. |
{"1014": 0.05694137513637543, "1052": 0.2539152204990387, "1997": 0.10026945173740387, "1999": 0.09584271162748337, "2029": 0.04487626627087593, "2047": 0.3019835948944092, "2063": 0.06154331564903259, "2078": 0.1808556467294693, "2109": 0.19782574474811554, "2116": 0.18248429894447327, "2179": 0.11865071207284927, "21... | 12207167 | PHENYLALANINE TOXICITY 158 Developing the 0. -M ethylphenylalanine Model. . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 160 Use of the a-Methyl phenylalanine Model in Brain Protein Synthesis . . . . . . . . . . . . . . . . . . . 161 TYROSINE TOXICITY 162 General Nutritional ... | Adverse effects of excessive consumption of amino acids. |
{"1005": 0.11691460013389587, "1011": 0.06612417846918106, "1017": 0.3485364317893982, "1019": 0.3777405619621277, "1050": 0.46914875507354736, "1997": 0.06520967930555344, "2000": 0.11430477350950241, "2003": 0.0354953333735466, "2011": 0.4248080551624298, "2034": 0.2983669638633728, "2043": 0.014542185701429844, "204... | 12207340 | The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is initiated by nucleolytic degradation of the 5'-terminated strands in a process termed end resection. End resection generates 3'-single-stranded DNA tails, substrates for Rad51 to catalyze homologous pairing and DNA strand exchange, and fo... | Mechanism and regulation of DNA end resection in eukaryotes. |
{"1003": 0.19862671196460724, "1014": 0.06977381557226181, "1018": 0.2918238639831543, "1020": 0.3588210940361023, "1043": 0.0752234235405922, "1050": 0.36494144797325134, "2004": 0.13243216276168823, "2007": 0.16690383851528168, "2012": 0.16110190749168396, "2020": 0.04113444685935974, "2028": 0.08513788133859634, "20... | 12209494 | BACKGROUND The case-fatality for intentional self-poisoning in the rural developing world is 10-50-fold higher than that in industrialised countries, mostly because of the use of highly toxic pesticides and plants. We therefore aimed to assess whether routine treatment with multiple-dose activated charcoal, to interrup... | Multiple-dose activated charcoal in acute self-poisoning: a randomised controlled trial |
{"1011": 0.13499516248703003, "1054": 0.17431432008743286, "2000": 0.034552380442619324, "2003": 0.11430477350950241, "2006": 0.8247235417366028, "2008": 0.07793712615966797, "2011": 0.4487839937210083, "2029": 0.2394166737794876, "2034": 0.01934296265244484, "2044": 0.3910386264324188, "2046": 0.03925827145576477, "20... | 12217662 | RAS and many other oncogenic proteins undergo a complex series of post-translational modifications that are initiated by the addition of an isoprenoid lipid through a process known as prenylation. Following prenylation, these proteins usually undergo endoproteolytic processing by the RCE1 protease and then carboxyl met... | Post-prenylation-processing enzymes as new targets in oncogenesis |
{"1014": 0.0174254160374403, "1038": 0.306306391954422, "1040": 0.20818853378295898, "1055": 0.09406650811433792, "1057": 0.11517547070980072, "1061": 0.1808556467294693, "1081": 0.6374238729476929, "2003": 0.02316705882549286, "2043": 0.04767346754670143, "2091": 0.08154398202896118, "2095": 0.07341018319129944, "2109... | 12224536 | BACKGROUND Reducing sugar-sweetened beverage (SSB) consumption is a recommended strategy to promote optimal health. OBJECTIVE The objective was to describe trends in SSB consumption among youth and adults in the United States. DESIGN We analyzed energy intake from SSBs among 22,367 youth aged 2-19 y and 29,133 adults a... | Trends in sugar-sweetened beverage consumption among youth and adults in the United States: 1999-2010. |
{"1011": 0.14095009863376617, "1015": 0.17020416259765625, "1017": 0.5313173532485962, "1041": 1.0855059623718262, "1043": 0.2478361576795578, "1045": 0.535327672958374, "1048": 0.5080875158309937, "1049": 0.6223390698432922, "1050": 0.2607102394104004, "1057": 1.105748176574707, "1996": 0.058784693479537964, "1997": 0... | 12225214 | Ubiquitination controls a broad range of cellular functions. The last step of the ubiquitination pathway is regulated by enzyme type 3 (E3) ubiquitin ligases. E3 enzymes are responsible for substrate specificity and catalyze the formation of an isopeptide bond between a lysine residue of the substrate (or the N terminu... | Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. |
{"1011": 0.13414156436920166, "1043": 0.029824240133166313, "1060": 0.07793712615966797, "1062": 1.2047537565231323, "2006": 0.23092569410800934, "2011": 0.5712664127349854, "2025": 0.0038986403960734606, "2051": 0.16110190749168396, "2061": 0.34370049834251404, "2064": 0.21922965347766876, "2070": 0.11081436276435852,... | 12232678 | Recent reports have suggested that birds lack a mechanism of wholesale dosage compensation for the Z sex chromosome. This discovery was rather unexpected, as all other animals investigated with chromosomal mechanisms of sex determination have some method to counteract the effects of gene dosage of the dominant sex chro... | All dosage compensation is local: Gene-by-gene regulation of sex-biased expression on the chicken Z chromosome |
{"1009": 0.07793712615966797, "1041": 0.00875066313892603, "1044": 0.07159364968538284, "1051": 0.1619328260421753, "1052": 0.07431721687316895, "1056": 0.16276304423809052, "1061": 0.37640097737312317, "2005": 0.11604541540145874, "2007": 0.1710275560617447, "2025": 0.2881702482700348, "2043": 0.0354953333735466, "204... | 12236208 | Patients with inflammatory bowel disease have an increased prevalence of osteoporosis, and suffer high rates of spinal bone loss. Hormone replacement therapy (HRT) is effective in the treatment and prevention of osteoporosis but has not been studied in patients with inflammatory bowel disease. A two year prospective st... | Hormone replacement therapy prevents bone loss in patients with inflammatory bowel disease. |
{"1011": 0.2493593990802765, "1019": 0.22626367211341858, "1038": 0.23092569410800934, "1044": 0.17759032547473907, "1052": 0.5844172835350037, "1054": 0.630689799785614, "2003": 0.24859806895256042, "2007": 0.014542185701429844, "2011": 0.18816383183002472, "2015": 0.10379679501056671, "2019": 0.7473171949386597, "202... | 12240507 | Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by haploinsufficiency of genes encoding ribosomal proteins (RPs). Perturbed ribosome biogenesis in DBA has been shown to induce a p53-mediated ribosomal stress response. However, the mechanisms of p53 activation and its relevance for the erythroi... | Disruption of the 5S RNP–Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia |
{"1003": 0.08064348995685577, "1015": 0.25845035910606384, "1016": 0.16524957120418549, "1017": 0.14433705806732178, "1018": 0.2105647772550583, "1019": 0.2881702482700348, "1020": 0.025073638185858727, "1021": 0.14686977863311768, "1022": 0.15023678541183472, "1026": 0.04487626627087593, "1052": 0.4624064862728119, "1... | 12258338 | CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs. However, whether pharmacist participation in the ICU at the time of drug prescribing reduces adverse events has not been studied. OBJECTIVE To measure the... | Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. |
{"1006": 0.02316705882549286, "1011": 0.23710809648036957, "1047": 0.812664806842804, "1997": 0.2089812457561493, "2000": 0.058784693479537964, "2005": 0.19541899859905243, "2007": 0.16690383851528168, "2029": 0.04207121208310127, "2064": 0.3930181860923767, "2075": 0.12642613053321838, "2099": 0.9485763907432556, "210... | 12265561 | The conformation of the ligand in complex with a macromolecular target can be studied by nuclear magnetic resonance (NMR) in solution for both tightly and weakly forming complexes. In the weak binding regime (k(off) > 10(4) Hz), the structure of the bound ligand is accessible also for very large complexes (>100 kDa), w... | Ligand-target interactions: what can we learn from NMR? |
{"1014": 0.44753631949424744, "1043": 0.46853771805763245, "1045": 0.20022670924663544, "1052": 0.48670899868011475, "1997": 0.043007105588912964, "2000": 0.10906458646059036, "2035": 0.030771657824516296, "2042": 0.23556606471538544, "2045": 0.13414156436920166, "2047": 0.28155985474586487, "2064": 0.32058215141296387... | 12271486 | BACKGROUND A central challenge of biology is to map and understand gene regulation on a genome-wide scale. For any given genome, only a small fraction of the regulatory elements embedded in the DNA sequence have been characterized, and there is great interest in developing computational methods to systematically map al... | MotifMap: integrative genome-wide maps of regulatory motif sites for model species |
{"1011": 0.05046287178993225, "1015": 0.3106105625629425, "1016": 0.3949938118457794, "1043": 0.7047978043556213, "1044": 0.42096930742263794, "1059": 0.5512100458145142, "1060": 0.2837681770324707, "1062": 0.9929623603820801, "2004": 1.0437490940093994, "2005": 0.29981520771980286, "2012": 0.29036402702331543, "2024":... | 12280462 | Bile acids are recognized as metabolic modulators. The present study was aimed at evaluating the effects of a potent Asbt inhibitor (264W94), which blocks intestinal absorption of bile acids, on glucose homeostasis in Zucker Diabetic Fatty (ZDF) rats. Oral administration of 264W94 for two wk increased fecal bile acid c... | Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. |
{"1011": 0.05970508232712746, "1015": 0.5696102976799011, "1039": 0.1946154683828354, "1052": 0.20660123229026794, "1996": 0.058784693479537964, "2002": 0.07341018319129944, "2007": 0.02316705882549286, "2010": 0.7445381283760071, "2011": 0.26146242022514343, "2012": 0.22937409579753876, "2026": 0.77198725938797, "2028... | 12315072 | At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the molecular mechanisms regulating first the priming and then maintenance of gene expression within one developmental pathway are essentially unknown. The hematopoi... | Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. |
{"1011": 0.0058422754518687725, "1038": 1.179255723953247, "1039": 0.04207121208310127, "2007": 0.0317181795835495, "2020": 0.026025565341114998, "2025": 0.1229778528213501, "2029": 0.24554696679115295, "2033": 0.1693800985813141, "2034": 0.13414156436920166, "2039": 0.5021947622299194, "2042": 0.055094651877880096, "2... | 12324049 | We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation program by whole-genome bisulfite sequencing and high-density microarrays. We observed that non-CpG methylation disappeared upon B cell commitment, whereas CpG methylation changed extensively during B cell maturation, showing... | Whole-genome fingerprint of the DNA methylome during human B cell differentiation |
{"1011": 0.1930064558982849, "1021": 0.4537591338157654, "1038": 0.026025565341114998, "1999": 0.0019512200960889459, "2005": 0.07341018319129944, "2008": 0.04394211992621422, "2010": 0.14095009863376617, "2011": 0.2231435477733612, "2026": 0.9783848524093628, "2029": 0.26146242022514343, "2058": 0.417115718126297, "20... | 12337611 | LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7 family. A role for LIN28B in cancer has been proposed but has not been established in vivo. Here, we report that LIN28B showed genomic aberrations and extensive overexpression in high-risk neuroblastoma compared to several other tumo... | LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression |
{"1011": 0.3750596046447754, "1014": 0.28743788599967957, "1040": 0.14939609169960022, "1041": 0.47463157773017883, "1043": 0.15526613593101501, "1052": 0.6312094330787659, "1056": 0.9052929878234863, "2003": 0.23247487843036652, "2029": 0.13499516248703003, "2062": 0.07884006202220917, "2084": 0.17267228662967682, "21... | 12358173 | Angiogenesis is a recently described prognostic factor in non-small-cell lung cancer. Platelet-derived endothelial cell growth factor (PD-ECGF), shown to be the enzyme thymidine phosphorylase (TP), induces angiogenesis in vitro and in vivo. High intracellular levels of the enzyme are associated with increased chemosens... | Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer. |
{"1018": 0.6086184978485107, "1041": 0.08603433519601822, "1044": 0.036437395960092545, "1050": 0.12038381397724152, "1061": 0.4512746334075928, "1997": 0.06520967930555344, "1998": 0.14686977863311768, "2029": 0.010684899985790253, "2035": 0.06977381557226181, "2039": 0.009718249551951885, "2043": 0.07341018319129944,... | 12364109 | According to construal level theory (N. Liberman, Y. Trope, & E. Stephan, in press; Y. Trope & N. Liberman, 2003), people use a more abstract, high construal level when judging, perceiving, and predicting more psychologically distal targets, and they judge more abstract targets as being more psychologically distal. The... | The association between psychological distance and construal level: evidence from an implicit association test. |
{"1037": 0.04487626627087593, "2003": 0.02887592278420925, "2051": 0.5404602885246277, "2063": 0.040196798741817474, "2064": 0.2983669638633728, "2065": 0.06795065850019455, "2071": 0.02887592278420925, "2079": 0.1889725625514984, "2109": 0.06612417846918106, "2121": 0.43244171142578125, "2129": 0.19541899859905243, "2... | 12370190 | The behavior of gene modules in complex synthetic circuits is often unpredictable. After joining modules to create a circuit, downstream elements (such as binding sites for a regulatory protein) apply a load to upstream modules that can negatively affect circuit function. Here we devised a genetic device named a load d... | A load driver device for engineering modularity in biological networks |
{"1011": 0.5215105414390564, "1038": 0.47766464948654175, "1048": 0.21530038118362427, "1055": 0.31204116344451904, "2004": 0.022212404757738113, "2005": 0.5033760666847229, "2012": 0.15275461971759796, "2029": 0.06429435312747955, "2033": 0.4093637466430664, "2063": 0.06703783571720123, "2080": 0.8981585502624512, "21... | 12370881 | AIM To examine the therapeutic/preventive potential of liposome-encapsulated spironolactone (SP; Lipo-SP) for acute lung injury (ALI) and fibrosis. MATERIALS & METHODS Lipo-SP was prepared by the film-ultrasonic method, and physicochemical and pharmacokinetic characterized for oral administration (10 and 20 mg/kg for S... | Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice. |
{"1014": 0.255429208278656, "1018": 0.31560876965522766, "1041": 0.11430477350950241, "1045": 0.0029254043474793434, "1048": 0.7827593088150024, "1052": 0.045809537172317505, "2001": 0.16359257698059082, "2011": 0.0606246218085289, "2012": 0.1485546976327896, "2013": 0.3177432417869568, "2020": 0.04953393340110779, "20... | 12383365 | ABSTRACT Lyme disease (LD) is emerging in Canada because of the northward expansion of the geographic range of the tick vector Ixodes scapularis (Say). Early detection of emerging areas of LD risk is critical to public health responses, but the methods to do so on a local scale are lacking. Passive tick surveillance ha... | Passive Surveillance for I. scapularis Ticks: Enhanced Analysis for Early Detection of Emerging Lyme Disease Risk |
{"1014": 0.43434104323387146, "1052": 0.1930064558982849, "2000": 0.0029254043474793434, "2005": 0.5033760666847229, "2007": 0.08782484382390976, "2011": 0.07884006202220917, "2029": 0.08782484382390976, "2034": 0.4770587682723999, "2039": 0.09228714555501938, "2050": 0.13670019805431366, "2051": 0.1477125883102417, "2... | 12409683 | BACKGROUND Artemisinin combination therapies (ACT), which are increasingly being introduced for treatment of Plasmodium falciparum malaria, are more effective against sexual stage parasites (gametocytes) than previous first-line antimalarials and therefore have the potential to reduce parasite transmission. The size of... | Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials |
{"1039": 0.29981520771980286, "1996": 0.15023678541183472, "1999": 0.012615402229130268, "2011": 0.32058215141296387, "2013": 0.6714286804199219, "2015": 0.1212492436170578, "2019": 0.4196864068508148, "2021": 0.2105647772550583, "2026": 1.0655186176300049, "2031": 0.3012613356113434, "2033": 0.5197699069976807, "2038"... | 12411274 | Skeletal muscle in vertebrates is derived from somites, epithelial structures of the paraxial mesoderm, yet many unrelated reports describe the occasional appearance of myogenic cells from tissues of nonsomite origin, suggesting either transdifferentiation or the persistence of a multipotent progenitor. Here, we show t... | Skeletal Myogenic Progenitors Originating from Embryonic Dorsal Aorta Coexpress Endothelial and Myogenic Markers and Contribute to Postnatal Muscle Growth and Regeneration |
{"1019": 0.05417001247406006, "1037": 0.02316705882549286, "1040": 0.3034266233444214, "1043": 0.09672962874174118, "1054": 0.08871890604496002, "2004": 0.0038986403960734606, "2006": 0.02412080205976963, "2025": 0.30558720231056213, "2038": 0.0913962796330452, "2042": 0.2674594223499298, "2089": 0.11517547070980072, "... | 12428137 | CONTEXT Gastroesophageal reflux (GER) has not previously been widely regarded as a hereditary disease. A few reports have suggested, however, that a genetic component may contribute to the incidence of GER, especially in its severe or chronic forms. OBJECTIVE To identify a genetic locus that cosegregates with a severe ... | Mapping of a gene for severe pediatric gastroesophageal reflux to chromosome 13q14. |
{"1014": 0.8212929964065552, "1015": 0.16690383851528168, "1016": 0.20580662786960602, "1038": 0.6296497583389282, "1043": 0.12384103983640671, "1044": 0.0797421783208847, "2000": 0.29255300760269165, "2002": 0.10731173306703568, "2005": 0.07612881064414978, "2011": 0.4203280806541443, "2047": 0.7067264318466187, "2048... | 12428497 | BACKGROUND Adoption of new and underutilized vaccines by national immunization programs is an essential step towards reducing child mortality. Policy decisions to adopt new vaccines in high mortality countries often lag behind decisions in high-income countries. Using the case of Haemophilus influenzae type b (Hib) vac... | Accelerating Policy Decisions to Adopt Haemophilus influenzae Type b Vaccine: A Global, Multivariable Analysis |
{"1020": 0.6212902665138245, "1044": 0.39367714524269104, "1056": 0.6872705817222595, "2002": 0.7009293437004089, "2007": 0.0770333781838417, "2008": 0.03831886500120163, "2011": 0.5483922958374023, "2015": 0.02792670577764511, "2029": 0.16359257698059082, "2046": 0.5415972471237183, "2063": 0.07341018319129944, "2075"... | 12428814 | Secretion systems require high-fidelity mechanisms to discriminate substrates among the vast cytoplasmic pool of proteins. Factors mediating substrate recognition by the type VI secretion system (T6SS) of Gram-negative bacteria, a widespread pathway that translocates effector proteins into target bacterial cells, have ... | Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates. |
{"1014": 0.4400174915790558, "1019": 0.37102460861206055, "1022": 0.1485546976327896, "1023": 0.2493593990802765, "1051": 0.5370414853096008, "1062": 0.06703783571720123, "2001": 0.1332872211933136, "2007": 0.18248429894447327, "2014": 0.09495500475168228, "2020": 0.014542185701429844, "2039": 0.21687394380569458, "204... | 12438901 | BACKGROUND For women with oestrogen receptor (ER)-positive early breast cancer, treatment with tamoxifen for 5 years substantially reduces the breast cancer mortality rate throughout the first 15 years after diagnosis. We aimed to assess the further effects of continuing tamoxifen to 10 years instead of stopping at 5 y... | Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial |
{"2004": 0.026025565341114998, "2005": 0.06429435312747955, "2008": 0.04860413447022438, "2011": 0.014542185701429844, "2012": 0.11168810725212097, "2015": 0.5318912267684937, "2024": 0.07884006202220917, "2037": 0.1064341589808464, "2050": 0.14518201351165771, "2054": 0.014542185701429844, "2064": 0.058784693479537964... | 12440953 | Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcin... | Roles for MicroRNAs in Conferring Robustness to Biological Processes |
{"1011": 0.2561853528022766, "1040": 0.2741633653640747, "1998": 0.05694137513637543, "2001": 0.2689530849456787, "2005": 0.08603433519601822, "2007": 0.14349138736724854, "2013": 0.02887592278420925, "2018": 0.04953393340110779, "2020": 0.1913948506116867, "2038": 0.3485364317893982, "2042": 0.5584990978240967, "2043"... | 12442311 | BACKGROUND The analgesic co-proxamol (paracetamol/dextropropoxyphene combination) has been widely involved in fatal poisoning. Concerns about its safety/effectiveness profile and widespread use for suicidal poisoning prompted its withdrawal in the UK in 2005, with partial withdrawal between 2005 and 2007, and full with... | Six-Year Follow-Up of Impact of Co-proxamol Withdrawal in England and Wales on Prescribing and Deaths: Time-Series Study |
{"1014": 0.1718502640724182, "1017": 0.07250232994556427, "1018": 0.029824240133166313, "1022": 0.04860413447022438, "1039": 0.17922431230545044, "1041": 0.7067264318466187, "1052": 0.16524957120418549, "1056": 0.20501139760017395, "1177": 0.613389253616333, "2007": 0.11343330889940262, "2012": 0.0752234235405922, "201... | 12443371 | OBJECTIVE To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We hypothesized that carrying 1 or more APOE rare (or minor) allele assessed in this study would be associated with having a... | Apolipoprotein E genotype and concussion in college athletes. |
{"1011": 0.056018441915512085, "1017": 0.20739519596099854, "1044": 0.8004589080810547, "1050": 0.03925827145576477, "2007": 0.04767346754670143, "2012": 0.3723714053630829, "2019": 1.0423725843429565, "2029": 0.1011524572968483, "2039": 0.1358480453491211, "2052": 0.014542185701429844, "2071": 0.03831886500120163, "20... | 12451492 | OBJECTIVE One of the theories involved in the pathogenesis of pregnancy induced hypertension involves salt and water retention. We aimed to measure the proenzyme convertase corin, responsible for pro-atrial natriuretic peptide (ANP) cleavage to active ANP, in plasma of hypertensive pregnant females. STUDY DESIGN Sixty ... | Plasma soluble corin and N-terminal pro-atrial natriuretic peptide levels in pregnancy induced hypertension. |
{"1011": 0.2969166338443756, "1017": 0.3519764244556427, "1018": 0.38441169261932373, "1020": 0.6000806093215942, "1039": 0.07793712615966797, "1043": 0.5080875158309937, "1044": 0.06337817758321762, "1045": 0.23710809648036957, "1048": 0.30558720231056213, "1050": 0.5523349046707153, "1052": 0.680370569229126, "2005":... | 12462961 | Cytochrome P450c17 catalyzes steroidogenic 17alpha-hydroxylase and 17,20 lyase activities. Expression of the gene for P450c17 is cAMP dependent, tissue specific, developmentally programmed, and varies among species. Binding of Sp1, Sp3, and NF1-C (nuclear factor 1-C) to the first 227 bp of 5'flanking DNA (-227/LUC) is ... | GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1. |
{"1011": 0.47827014327049255, "1020": 1.0229004621505737, "1048": 1.0158531665802002, "1053": 0.2786078155040741, "1055": 0.42225050926208496, "2001": 0.02412080205976963, "2003": 0.0058422754518687725, "2005": 0.15023678541183472, "2012": 0.6970458030700684, "2015": 0.9531047344207764, "2040": 0.055094651877880096, "2... | 12470783 | PURPOSE There is a need for valid and reliable short scales that can be used to assess social networks and social supports and to screen for social isolation in older persons. DESIGN AND METHODS The present study is a cross-national and cross-cultural evaluation of the performance of an abbreviated version of the Lubbe... | Performance of an abbreviated version of the Lubben Social Network Scale among three European community-dwelling older adult populations. |
{"1003": 0.2659635543823242, "1022": 0.053244512528181076, "1028": 0.1229778528213501, "1052": 1.0444365739822388, "1609": 0.37707099318504333, "2003": 0.034552380442619324, "2020": 0.07612881064414978, "2035": 0.3560888469219208, "2042": 0.15610189735889435, "2047": 0.13414156436920166, "2075": 0.6980181336402893, "20... | 12471115 | BACKGROUND The pneumococcus is a diverse pathogen whose primary niche is the nasopharynx. Over 90 different serotypes exist, and nasopharyngeal carriage of multiple serotypes is common. Understanding pneumococcal carriage is essential for evaluating the impact of pneumococcal vaccines. Traditional serotyping methods ar... | The PneuCarriage Project: A Multi-Centre Comparative Study to Identify the Best Serotyping Methods for Examining Pneumococcal Carriage in Vaccine Evaluation Studies |
{"1048": 0.8861536383628845, "1054": 1.151856780052185, "1996": 0.2105647772550583, "2008": 0.045809537172317505, "2015": 0.01934296265244484, "2029": 0.2478361576795578, "2038": 0.040196798741817474, "2047": 0.020300358533859253, "2075": 0.4286321699619293, "2076": 0.1718502640724182, "2089": 0.10379679501056671, "212... | 12486491 | Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue-specific patterning defects, including pronounced homeotic transformations of ... | Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning |
{"1020": 0.022212404757738113, "1999": 0.16359257698059082, "2001": 0.1693800985813141, "2004": 0.1710275560617447, "2008": 0.053244512528181076, "2020": 0.3177432417869568, "2029": 0.09317722171545029, "2030": 0.650757372379303, "2034": 0.04487626627087593, "2041": 0.011650617234408855, "2046": 0.7057625651359558, "20... | 12489130 | An orthotopic model of human melanoma was developed in which malignant cells were injected into human skin grafted to nude and SCID mice. Melanoma cells proliferated and invaded the human skin grafts with characteristic patterns. Three of six melanomas grew as multiple nodules and infiltered the grafts without major ar... | Growth and invasion of human melanomas in human skin grafted to immunodeficient mice. |
{"1011": 0.13157635927200317, "1044": 0.5601736903190613, "1051": 0.0174254160374403, "1052": 0.03266380727291107, "1996": 0.0606246218085289, "1997": 0.016465263441205025, "1999": 0.22859740257263184, "2011": 0.4709797203540802, "2015": 0.2652147710323334, "2024": 0.09672962874174118, "2026": 0.5162794589996338, "2029... | 12489688 | Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their primary function, the phagocytosis and destruction of microorganisms. When coated with opsonins (generally complement and/or antibody), microorganisms bind to specific receptors on the surface of the phagocyte and invagination of t... | Myeloperoxidase: friend and foe. |
{"1011": 0.3683255612850189, "1015": 0.4794800877571106, "1041": 0.8357921838760376, "1059": 0.5909284353256226, "1156": 0.17020416259765625, "1999": 0.04953393340110779, "2004": 0.10993985831737518, "2007": 0.12814582884311676, "2011": 0.2822965085506439, "2015": 0.14264501631259918, "2028": 0.18329764902591705, "2029... | 12513042 | The importance of prostaglandin E(2) in various pathophysiological events emphasizes the necessity of understanding the role of PGE synthases (PGESs) in vivo. However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1) to the physiological healing processes of gastric ulcers, or to angi... | Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers. |
{"1011": 0.1358480453491211, "1014": 0.401551216840744, "1051": 0.06429435312747955, "1052": 0.6233867406845093, "1609": 0.5789587497711182, "1998": 0.0797421783208847, "2007": 0.32764431834220886, "2015": 0.27712854743003845, "2019": 0.9209672808647156, "2020": 0.053244512528181076, "2028": 0.11865071207284927, "2029"... | 12513972 | BACKGROUND Intracranial aneurysm (IA) is significantly more prevalent in patients with coarctation of the aorta or bicuspid aortic valve than in the general population, suggesting a common pathophysiology connecting IA and aortopathy. Here, we analyzed echocardiographic aortic root dimension (ARD) in patients with IA t... | Echocardiographic Evidence of Innate Aortopathy in the Human Intracranial Aneurysm |
{"1009": 0.304147332906723, "1014": 0.3662964701652527, "1020": 0.23787821829319, "1022": 0.0317181795835495, "1023": 0.24631060659885406, "1044": 0.20501139760017395, "1052": 0.935633659362793, "1058": 0.21530038118362427, "1059": 0.14686977863311768, "1060": 0.38374659419059753, "2001": 0.0038986403960734606, "2012":... | 12549585 | Pulse wave velocity (PWV) was measured in the aorta, right leg and arm of 90 control subjects (CS) and 92 hemodialysis patients (HD) of the same age and mean arterial pressure (MAP). Blood chemistry, including blood lipids, and echographic dimensions of the aorta, were measured in all subjects. Presence of aortic calci... | Aortic and large artery compliance in end-stage renal failure. |
{"1011": 0.14095009863376617, "1048": 0.20739519596099854, "1052": 0.5596157908439636, "1165": 1.1756457090377808, "2003": 0.2741633653640747, "2008": 0.13670019805431366, "2011": 0.34508460760116577, "2024": 0.043007105588912964, "2029": 0.36697331070899963, "2063": 0.02792670577764511, "2076": 0.012615402229130268, "... | 12552297 | DNA polymerase lambda (polλ) is a recently identified DNA polymerase whose cellular function remains elusive. Here we show, that polλ participates at the molecular level in a chromosomal context, in the repair of DNA double strand breaks (DSB) via non-homologous end joining (NHEJ) in mammalian cells. The expression of ... | The DNA polymerase λ is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells |
{"1014": 0.4518963396549225, "1052": 0.495672345161438, "1054": 0.055094651877880096, "2007": 0.5707147121429443, "2015": 0.7809720039367676, "2018": 0.15943801403045654, "2020": 0.026976587250828743, "2021": 0.083342544734478, "2022": 0.18004031479358673, "2031": 0.05970508232712746, "2051": 0.16276304423809052, "2053... | 12561083 | BACKGROUND Several studies have demonstrated that women with nonobstructive coronary disease have a high rate of subsequent investigations, rehospitalizations for recurrent chest pain, and repeat coronary angiography. The sex specificity of this finding is unclear. We therefore undertook an evaluation of sex difference... | Angina with "normal" coronary arteries: sex differences in outcomes. |
{"1011": 0.06246116757392883, "1043": 0.4709797203540802, "1044": 0.09584271162748337, "1047": 1.072225570678711, "1050": 0.4926934838294983, "1164": 0.6343214511871338, "2005": 0.06154331564903259, "2029": 0.3106105625629425, "2039": 0.3381449282169342, "2063": 1.1211429834365845, "2076": 0.05046287178993225, "2179": ... | 12580014 | Expression of the intermediate filament protein keratin 17 (K17) is robustly upregulated in inflammatory skin diseases and in many tumors originating in stratified and pseudostratified epithelia. We report that autoimmune regulator (Aire), a transcriptional regulator, is inducibly expressed in human and mouse tumor ker... | Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes |
{"1011": 0.2539152204990387, "1016": 0.1332872211933136, "1047": 1.018678069114685, "2005": 0.07250232994556427, "2007": 0.025073638185858727, "2008": 0.20739519596099854, "2011": 0.3554046154022217, "2012": 0.5370414853096008, "2015": 0.18573370575904846, "2024": 0.15023678541183472, "2029": 0.25088030099868774, "2039... | 12582729 | BACKGROUND Upregulated by atheroprotective flow, the transcription factor Krüppel-like factor 2 (KLF2) is crucial for maintaining endothelial function. MicroRNAs (miRNAs) are noncoding small RNAs that regulate gene expression at the posttranscriptional level. We examined the role of miRNAs, particularly miR-92a, in the... | Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a. |
{"1014": 0.5762182474136353, "1015": 0.27786844968795776, "1016": 0.9162907600402832, "1017": 0.6149744987487793, "1018": 0.009718249551951885, "1020": 0.36358460783958435, "1043": 0.33675122261047363, "1044": 0.7692760229110718, "1053": 0.44566190242767334, "1997": 0.32764431834220886, "2001": 0.025073638185858727, "2... | 12584053 | OBJECTIVE To measure whether the benefits of a single education and self management structured programme for people with newly diagnosed type 2 diabetes mellitus are sustained at three years. DESIGN Three year follow-up of a multicentre cluster randomised controlled trial in primary care, with randomisation at practice... | Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care |
{"1011": 0.4879087805747986, "1015": 0.6911921501159668, "1017": 0.11430477350950241, "1020": 0.030771657824516296, "1044": 0.5936289429664612, "1048": 0.30558720231056213, "1050": 0.08154398202896118, "1996": 0.0038986403960734606, "1997": 0.08064348995685577, "1999": 0.09317722171545029, "2002": 0.11865071207284927, ... | 12588500 | Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the mole... | Acetylation of Histone H3 Lysine 56 Regulates Replication-Coupled Nucleosome Assembly |
{"1011": 0.3877306580543518, "1041": 0.5903874635696411, "1048": 0.021256839856505394, "1051": 0.045809537172317505, "1055": 0.7934166193008423, "1056": 0.22782009840011597, "1999": 0.14264501631259918, "2003": 0.2689530849456787, "2004": 0.13670019805431366, "2011": 0.34922540187835693, "2015": 1.2421036958694458, "20... | 12622860 | S-trans,trans-Farnesylthiosalicylic acid (FTS) is a novel farnesylated rigid carboxylic acid derivative. In cell-free systems, it acts as a potent competitive inhibitor (Ki = 2.6 microM) of the enzyme prenylated protein methyltransferase (PPMTase), which methylates the carboxyl-terminal S-prenylcysteine in a large numb... | Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid. |
{"1009": 0.2881702482700348, "1011": 0.10731173306703568, "1016": 0.22782009840011597, "1039": 0.5376120805740356, "1044": 0.07612881064414978, "1049": 0.29619070887565613, "1055": 0.3409265875816345, "1058": 0.12470348179340363, "1060": 0.20102575421333313, "1996": 0.045809537172317505, "1999": 0.1946154683828354, "20... | 12631182 | The phagocyte NADPH oxidase (NOX2) is critical for the bactericidal activity of phagocytic cells and plays a major role in innate immunity. We showed recently that NOX2 activity in mouse dendritic cells (DCs) prevents acidification of phagosomes, promoting antigen cross-presentation. In order to investigate the role of... | NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells. |
{"1011": 0.3662964701652527, "1021": 0.3916989266872406, "1039": 0.3443928062915802, "2000": 0.025073638185858727, "2004": 0.004870930220931768, "2005": 0.28963330388069153, "2023": 0.1332872211933136, "2043": 0.14095009863376617, "2044": 0.083342544734478, "2047": 0.23092569410800934, "2076": 0.07068414986133575, "207... | 12631697 | Limited neural input results in muscle weakness in neuromuscular disease because of a reduction in the density of muscle innervation, the rate of neuromuscular junction activation or the efficiency of synaptic transmission. We developed a small-molecule fast-skeletal-troponin activator, CK-2017357, as a means to increa... | Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases |
{"1017": 0.0058422754518687725, "1018": 0.14518201351165771, "1999": 0.9842413663864136, "2003": 0.32270604372024536, "2011": 0.015504186972975731, "2024": 0.4450363218784332, "2029": 0.06520967930555344, "2044": 0.04487626627087593, "2072": 0.14349138736724854, "2075": 0.31132611632347107, "2076": 0.42225050926208496,... | 12640810 | Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not understood. We have dissected the stages of invadopodium assembly and maturation and show that invadopodia use cortactin phosphorylation as a master switch during the... | Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation |
{"1039": 0.7380234599113464, "2004": 0.10291612148284912, "2005": 0.25995752215385437, "2011": 0.255429208278656, "2025": 0.3554046154022217, "2029": 0.06703783571720123, "2060": 0.20739519596099854, "2079": 0.28890204429626465, "2091": 0.18329764902591705, "2102": 0.8450632095336914, "2109": 0.13925230503082275, "2147... | 12641252 | Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not induce immunogenic cell death. Here we show that anthracyclins induce the rapid, preapoptotic translocation of calreticulin (CRT) to the cell... | Calreticulin exposure dictates the immunogenicity of cancer cell death |
{"1001": 0.4494072198867798, "1011": 0.2184450328350067, "1016": 0.1358480453491211, "1017": 0.46424978971481323, "1019": 0.22859740257263184, "1022": 0.05694137513637543, "1051": 0.5347557663917542, "1055": 0.7201237678527832, "1057": 0.9621002674102783, "1060": 0.6348392367362976, "1997": 0.01934296265244484, "1999":... | 12642224 | DNA oligonucleotide complementary to sequences in the 5' third of U3 snRNA were injected into Xenopus oocyte nuclei to disrupt endogenous U3 snRNA. The effect of this treatment on rRNA processing was examined. We found that some toads have a single rRNA processing pathway, whereas in other toads, two rRNA processing pa... | In vivo disruption of Xenopus U3 snRNA affects ribosomal RNA processing. |
{"1016": 0.11865071207284927, "1039": 0.07068414986133575, "1044": 0.7592713832855225, "1053": 0.15359249711036682, "1157": 0.21530038118362427, "2001": 0.0317181795835495, "2005": 0.11691460013389587, "2010": 0.8459017872810364, "2011": 0.16359257698059082, "2029": 0.043007105588912964, "2057": 0.09317722171545029, "2... | 12643937 | Signaling pathways that respond to DNA damage are essential for the maintenance of genome stability and are linked to many diseases, including cancer. Here, a genome-wide siRNA screen was employed to identify additional genes involved in genome stabilization by monitoring phosphorylation of the histone variant H2AX, an... | A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. |
{"1011": 0.17759032547473907, "1017": 0.1734936386346817, "1020": 0.757441520690918, "1038": 0.09317722171545029, "1042": 0.8450632095336914, "1045": 0.28155985474586487, "1156": 0.5398913025856018, "1999": 0.004870930220931768, "2007": 0.10993985831737518, "2011": 0.3325583338737488, "2029": 0.28890204429626465, "2076... | 12650610 | We have previously shown that the integrin beta6 is neo-expressed in invasive oral squamous cell carcinoma (SCC) and is correlated with oral tumor progression. However, the mechanism by which the integrin beta6 promotes oral tumor progression is not well understood. The purpose of the present study was to determine whe... | Alphavbeta6-Fyn signaling promotes oral cancer progression. |
{"100": 0.11081436276435852, "1011": 0.24401791393756866, "1017": 0.08064348995685577, "1996": 0.04487626627087593, "2003": 0.25694093108177185, "2004": 0.007782140281051397, "2008": 0.26146242022514343, "2011": 0.11691460013389587, "2015": 0.41840189695358276, "2024": 0.472198486328125, "2029": 0.23015019297599792, "2... | 12652963 | MicroRNAs (miRNAs) are ∼22 nt non-coding RNAs that typically bind to the 3' UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. Here, we report that miRNAs can also regulate gene expression by targeting non-coding antisense transcripts in human cells. Specifically, we s... | miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. |
{"1009": 0.4337083101272583, "1011": 0.1011524572968483, "1014": 0.29400965571403503, "1017": 0.34370049834251404, "1019": 0.03925827145576477, "1020": 0.10026945173740387, "1021": 0.0038986403960734606, "1022": 0.1913948506116867, "1023": 0.11778303235769272, "1026": 0.015504186972975731, "1048": 0.05046287178993225, ... | 12658073 | The gut microbiota has been proposed as an environmental factor that affects the development of metabolic and inflammatory diseases in mammals. Recent reports indicate that gut bacteria-derived lipopolysaccharide (LPS) can initiate obesity and insulin resistance in mice; however, the molecular interactions responsible ... | Regulation of Serum Amyloid A3 (SAA3) in Mouse Colonic Epithelium and Adipose Tissue by the Intestinal Microbiota |
{"1015": 0.0354953333735466, "1016": 0.7755908370018005, "1038": 0.37035053968429565, "1043": 0.6348392367362976, "1044": 0.4248080551624298, "1056": 0.841701865196228, "2000": 0.06429435312747955, "2005": 0.23556606471538544, "2012": 0.16110190749168396, "2013": 0.2247048318386078, "2045": 0.004870930220931768, "2048"... | 12662435 | Abstract | Populations of African descent are at the forefront of the worldwide epidemic of type 2 diabetes mellitus (T2DM). The burden of T2DM is amplified by diagnosis after preventable complications of the disease have occurred. Earlier detection would result in a reduction in undiagnosed T2DM, more accurate statist... | Reversing the tide — diagnosis and prevention of T2DM in populations of African descent |
{"1017": 0.05046287178993225, "1041": 0.18816383183002472, "1043": 0.25088030099868774, "2000": 0.05046287178993225, "2001": 0.01934296265244484, "2005": 0.3560888469219208, "2029": 0.025073638185858727, "2044": 0.3723714053630829, "2051": 0.2607102394104004, "2058": 0.0029254043474793434, "2067": 0.5871354341506958, "... | 12667988 | Twenty-seven migraine headache patients were divided into three equal groups which received thermal biofeedback, frontalis EMG biofeedback, or relaxation training. Training was given under "massed" practice conditions (nine sessions per week) and consisted of 18 training sessions and six test-generalisation sessions. W... | Biofeedback and relaxation in the treatment of migraine headaches: comparative effectiveness and physiological correlates. |
{"1011": 0.5707147121429443, "1015": 0.1212492436170578, "1017": 0.07341018319129944, "1039": 0.8264343738555908, "1044": 0.401551216840744, "1045": 0.47158926725387573, "2000": 0.04207121208310127, "2002": 0.0797421783208847, "2003": 0.19220098853111267, "2005": 0.18411032855510712, "2007": 0.3134697377681732, "2011":... | 12669325 | High-throughput methods based on chromosome conformation capture have greatly advanced our understanding of the three-dimensional (3D) organization of genomes but are limited in resolution by their reliance on restriction enzymes. Here we describe a method called DNase Hi-C for comprehensively mapping global chromatin ... | Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes |
{"1011": 0.10467668622732162, "1016": 0.20660123229026794, "1044": 0.4914994537830353, "1045": 0.8298473954200745, "1048": 0.6202403903007507, "1049": 0.33953672647476196, "1056": 0.5517725944519043, "2008": 0.025073638185858727, "2010": 0.7314660549163818, "2011": 0.3325583338737488, "2015": 0.04487626627087593, "2029... | 12670680 | In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes their homing to lymph nodes, promoting T helper type 2 (T(H)2) cell differentiation and enhanci... | BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS |
{"1004": 0.045809537172317505, "1019": 0.03360854089260101, "1020": 0.17431432008743286, "1040": 0.07431721687316895, "1041": 0.012615402229130268, "2000": 0.10291612148284912, "2001": 0.16110190749168396, "2005": 0.07250232994556427, "2015": 0.5461324453353882, "2020": 0.07341018319129944, "2022": 0.09672962874174118,... | 12672066 | IMPORTANCE In 2011, the Centers for Medicare & Medicaid Services (CMS) approved intensive behavioral weight loss counseling for approximately 14 face-to-face, 10- to 15-minute sessions over 6 months for obese beneficiaries in primary care settings, when delivered by physicians and other CMS-defined primary care practit... | Behavioral treatment of obesity in patients encountered in primary care settings: a systematic review. |
{"1015": 0.4879087805747986, "1039": 0.12728634476661682, "1041": 0.7809720039367676, "1043": 0.7845434546470642, "1052": 0.11517547070980072, "1061": 0.1808556467294693, "2002": 0.43812891840934753, "2005": 0.08782484382390976, "2007": 0.10731173306703568, "2011": 0.34370049834251404, "2025": 0.015504186972975731, "20... | 12685434 | Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown. Epidermal growth factor receptor (EGFR) activation by amplification or mutation is one of the most frequent genetic lesions in a variety of human tumors. These include gliobla... | Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma |
{"1011": 0.34508460760116577, "1043": 0.12556517124176025, "1050": 0.22548456490039825, "1052": 0.007782140281051397, "1996": 0.29473719000816345, "1997": 0.06246116757392883, "2007": 0.4337083101272583, "2008": 0.04953393340110779, "2011": 0.3084607720375061, "2015": 0.2160874605178833, "2025": 0.15275461971759796, "2... | 12691537 | The archaeal ATPase complex PAN, the homolog of the eukaryotic 26S proteasome-regulatory ATPases, was shown to associate transiently with the 20S proteasome upon binding of ATP or ATPgammaS, but not ADP. By electron microscopy (EM), PAN appears as a two-ring structure, capping the 20S, and resembles two densities in th... | ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. |
{"1011": 0.15526613593101501, "1050": 0.4812922179698944, "1052": 0.33953672647476196, "1056": 0.5805994272232056, "1164": 0.22157983481884003, "1999": 0.2018241584300995, "2003": 0.006812678650021553, "2005": 0.1808556467294693, "2029": 0.06520967930555344, "2035": 0.015504186972975731, "2050": 0.18978065252304077, "2... | 12705056 | The increasing understanding of the role of cytokines in autoimmunity, and the observation that tumour necrosis factor alpha (TNFalpha) is central to the inflammatory and destructive process common to several human autoimmune diseases, has led to a new generation of therapeutics, the TNFalpha blocking agents. In this a... | Cytokines and anti-cytokine biologicals in autoimmunity: present and future. |
{"1014": 0.31489628553390503, "1021": 0.34715715050697327, "1051": 0.4734157919883728, "2007": 0.06795065850019455, "2035": 0.3248254358768463, "2051": 0.1384023278951645, "2053": 0.08692999184131622, "2086": 0.2026219218969345, "2089": 0.1064341589808464, "2090": 0.1734936386346817, "2092": 0.0752234235405922, "2095":... | 12709184 | IMPORTANCE Some evidence suggests vegetarian dietary patterns may be associated with reduced mortality, but the relationship is not well established. OBJECTIVE To evaluate the association between vegetarian dietary patterns and mortality. DESIGN Prospective cohort study; mortality analysis by Cox proportional hazards r... | Vegetarian dietary patterns and mortality in Adventist Health Study 2. |
{"1011": 0.03360854089260101, "1061": 0.3784096837043762, "1999": 0.004870930220931768, "2004": 0.08244366943836212, "2005": 0.31845372915267944, "2006": 0.6054253578186035, "2008": 0.03831886500120163, "2011": 0.40546512603759766, "2029": 0.25995752215385437, "2033": 0.35745587944984436, "2063": 0.1510767638683319, "2... | 12737132 | The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent ... | TEAD mediates YAP-dependent gene induction and growth control. |
{"1009": 0.32058215141296387, "1011": 0.45623743534088135, "1019": 0.0019512200960889459, "1043": 0.28670501708984375, "1044": 0.3191637098789215, "2003": 0.025073638185858727, "2004": 0.0752234235405922, "2013": 0.46853771805763245, "2020": 0.11865071207284927, "2024": 0.2786078155040741, "2029": 0.23247487843036652, ... | 12742164 | Stem cells, which are clonogenic cells with self-renewal and multilineage differentiation properties, have the potential to replace or repair damaged tissue. We have directly isolated clonogenic human central nervous system stem cells (hCNS-SC) from fresh human fetal brain tissue, using antibodies to cell surface marke... | Direct isolation of human central nervous system stem cells. |
{"1011": 0.151916041970253, "1016": 0.22704219818115234, "1022": 0.2493593990802765, "1041": 0.6244332790374756, "1048": 0.31489628553390503, "1051": 0.3381449282169342, "1052": 0.7629209756851196, "1998": 0.10555581003427505, "2007": 0.31845372915267944, "2011": 0.1751343309879303, "2015": 0.5021947622299194, "2020": ... | 12762485 | AIM Several studies have investigated the expression of the cytokeratins (CKs), vimentin, the epithelial growth factor receptor (EGFR), the oestrogen receptor (ER), and the progesterone receptor (PgR), in breast cancer, but no study has directly compared p53 mutations with these phenotypic and differentiation markers i... | p53 mutation in breast cancer. Correlation with cell kinetics and cell of origin. |
{"1014": 0.2576959431171417, "1019": 0.176772341132164, "1021": 0.07341018319129944, "1023": 0.11081436276435852, "1038": 0.5805994272232056, "1039": 0.15610189735889435, "1044": 0.12384103983640671, "1053": 0.026025565341114998, "1058": 0.05786345899105072, "1999": 0.12814582884311676, "2004": 0.11081436276435852, "20... | 12770738 | BACKGROUND Questions remain as to whether higher levels of cardiorespiratory fitness, a measure of regular physical activity, are associated with lower risk of cardiovascular disease (CVD) mortality in overweight and obese individuals with diabetes. Our objective was to quantify the independent and joint relations of c... | Cardiorespiratory fitness and body mass index as predictors of cardiovascular disease mortality among men with diabetes. |
{"1003": 0.043007105588912964, "1018": 0.08871890604496002, "1019": 0.15693697333335876, "1023": 0.08782484382390976, "1039": 0.36967599391937256, "1058": 0.021256839856505394, "2001": 0.3248254358768463, "2013": 0.176772341132164, "2018": 0.21687394380569458, "2038": 0.25088030099868774, "2042": 0.18978065252304077, "... | 12779444 | The number of women dying from cervical cancer in 1997 was 7% lower than in 1996 and has fallen by over 25% since 1992.1 Such rapid change must be at least partly due to cervical screening, although strong cohort effects have caused large fluctuations in cervical mortality in the past.2 We modelled mortality data, taki... | Effect of screening on cervical cancer mortality in England and Wales: analysis of trends with an age period cohort model. |
{"1017": 0.13157635927200317, "1040": 0.2089812457561493, "1042": 0.5860490798950195, "1043": 0.3982778787612915, "1047": 0.36967599391937256, "1050": 0.18654440343379974, "1055": 0.1477125883102417, "1155": 0.17840765416622162, "1999": 0.03925827145576477, "2004": 0.6553317308425903, "2007": 0.4248080551624298, "2011"... | 12785130 | Src family kinases (SFKs) play critical roles in the regulation of many cellular functions by growth factors, G-protein-coupled receptors and ligand-gated ion channels. Recent data have shown that SFKs serve as a convergent point of multiple signaling pathways regulating N-methyl-d-aspartate (NMDA) receptors in the cen... | The regulation of N-methyl-D-aspartate receptors by Src kinase. |
{"1011": 0.1332872211933136, "1053": 0.014542185701429844, "1997": 0.09228714555501938, "2003": 0.10818854719400406, "2005": 0.2247048318386078, "2008": 0.04953393340110779, "2029": 0.11256109178066254, "2038": 0.0009760859538801014, "2047": 0.16442140936851501, "2057": 0.055094651877880096, "2064": 0.11081436276435852... | 12787125 | The remarkable gene knockdown technique of RNAi has opened exciting new avenues for genetic screens in model organisms and human cells. Here we describe the current state of the art for RNAi screening, and stress the importance of well-designed assays and of analytical approaches for large-scale screening experiments, ... | The art and design of genetic screens: RNA interference |
{"1037": 0.022212404757738113, "1039": 0.04207121208310127, "1058": 0.09228714555501938, "2000": 0.2145126610994339, "2022": 0.11691460013389587, "2039": 0.055094651877880096, "2046": 0.06977381557226181, "2052": 0.10818854719400406, "2062": 0.3547199070453644, "2064": 0.38041436672210693, "2071": 0.11865071207284927, ... | 12789595 | It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of online options illustrated in the figure must surely make learning more exciting, effective, and likely to be retained. This ... | Computer assisted learning in undergraduate medical education. |
{"1014": 0.43812891840934753, "1018": 0.3381449282169342, "1039": 0.7314660549163818, "1048": 0.31560876965522766, "1061": 0.8238670229911804, "1998": 0.32199856638908386, "2015": 0.1889725625514984, "2035": 0.5500838756561279, "2039": 0.02412080205976963, "2043": 0.0029254043474793434, "2044": 0.14686977863311768, "20... | 12794099 | BACKGROUND There is overwhelming evidence that behavioural factors influence health, but their combined impact on the general population is less well documented. We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community. METHODS AND FINDIN... | Combined Impact of Health Behaviours and Mortality in Men and Women: The EPIC-Norfolk Prospective Population Study |
{"1019": 0.176772341132164, "1020": 0.2089812457561493, "1022": 0.013579257763922215, "1023": 0.10818854719400406, "1054": 0.5789587497711182, "1061": 0.3283478021621704, "2003": 0.07250232994556427, "2012": 0.016465263441205025, "2026": 0.8349450826644897, "2044": 0.18004031479358673, "2046": 0.5816917419433594, "2064... | 12800122 | Subdividing proliferating tissues into compartments is an evolutionarily conserved strategy of animal development [1-6]. Signals across boundaries between compartments can result in local expression of secreted proteins organizing growth and patterning of tissues [1-6]. Sharp and straight interfaces between compartment... | Increased Cell Bond Tension Governs Cell Sorting at the Drosophila Anteroposterior Compartment Boundary |
{"2004": 0.46608972549438477, "2005": 0.37371641397476196, "2013": 0.6522845029830933, "2015": 0.32270604372024536, "2031": 0.018384648486971855, "2038": 0.15777134895324707, "2040": 0.22859740257263184, "2042": 0.04113444685935974, "2045": 0.2667117714881897, "2054": 0.1873544454574585, "2064": 0.04207121208310127, "2... | 12801438 | The use of and search for drugs and dietary supplements derived from plants have accelerated in recent years. Ethnopharmacologists, botanists, microbiologists, and natural-products chemists are combing the Earth for phytochemicals and "leads" which could be developed for treatment of infectious diseases. While 25 to 50... | Plant products as antimicrobial agents. |
{"2003": 0.19862671196460724, "2054": 0.26820653676986694, "2070": 0.09761575609445572, "2075": 0.175953671336174, "2079": 0.09761575609445572, "2166": 0.07068414986133575, "2287": 0.18329764902591705, "2319": 0.06246116757392883, "2339": 0.28670501708984375, "2358": 0.8658194541931152, "2458": 0.33675122261047363, "25... | 12804937 | Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears in organisms ranging from microbes to metazoans, and its characteristics depend both on the biophysical parameters governing gene ... | Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences |
{"1011": 0.2105647772550583, "1018": 0.15860503911972046, "1039": 0.07341018319129944, "1052": 0.045809537172317505, "1060": 0.757441520690918, "1156": 0.27342069149017334, "2002": 0.4709797203540802, "2005": 0.15442965924739838, "2008": 0.06977381557226181, "2011": 0.09672962874174118, "2020": 0.09495500475168228, "20... | 12805683 | Mammalian nuclear hormone receptors (NHRs), such as liver X receptor, farnesoid X receptor, and peroxisome proliferator-activated receptors (PPARs), precisely control energy metabolism. Consequently, these receptors are important targets for the treatment of metabolic diseases, including diabetes and obesity. A thoroug... | Nuclear Hormone Receptor NHR-49 Controls Fat Consumption and Fatty Acid Composition in C. elegans |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.