spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1014": 0.5021947622299194, "1020": 0.33115679025650024, "1038": 0.7295845746994019, "1040": 0.26820653676986694, "1041": 0.2983669638633728, "1042": 0.8625272512435913, "1044": 0.6254787445068359, "1053": 0.0029254043474793434, "1998": 0.1693800985813141, "1999": 0.07431721687316895, "2011": 0.006812678650021553, "20... | 12810152 | CONTEXT Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart disease (CHD) are not available. OBJECTIVE To examine intakes of folate and vitamin B6 in relation to the inci... | Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. |
{"1039": 0.3346569836139679, "1045": 0.1685553640127182, "1051": 1.1274882555007935, "1062": 0.7809720039367676, "1996": 0.14179791510105133, "1998": 0.1212492436170578, "2003": 0.025073638185858727, "2005": 0.09228714555501938, "2029": 0.14602625370025635, "2043": 0.25995752215385437, "2044": 0.27564704418182373, "204... | 12821938 | Sexual reproduction depends upon meiosis for the generation of haploid gamete nuclei, which unite after fertilization to form the diploid zygote. The oocytes of most animal species arrest during meiotic prophase, and complete meiosis in response to intercellular signaling in a process called meiotic maturation. Oocyte ... | Control of oocyte meiotic maturation and fertilization. |
{"1011": 0.11778303235769272, "1996": 0.021256839856505394, "1997": 0.21530038118362427, "1998": 0.2223619967699051, "2011": 0.15359249711036682, "2013": 0.14939609169960022, "2015": 0.20421554148197174, "2037": 0.28155985474586487, "2043": 0.052318159490823746, "2046": 0.1212492436170578, "2048": 0.5330380201339722, "... | 12824568 | The organization of cells, emerging from cell-cell interactions, can give rise to collective properties. These properties are adaptive when together cells can face environmental challenges that they separately cannot. One particular challenge that is important for microorganisms is migration. In this study, we show how... | From Cell Differentiation to Cell Collectives: Bacillus subtilis Uses Division of Labor to Migrate |
{"1011": 0.08782484382390976, "1018": 0.0752234235405922, "1039": 0.13157635927200317, "1049": 0.6027565002441406, "1998": 0.011650617234408855, "1999": 0.043007105588912964, "2004": 0.18329764902591705, "2007": 0.010684899985790253, "2008": 0.1930064558982849, "2011": 0.3662964701652527, "2013": 0.4248080551624298, "2... | 12827098 | Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis and fate-mapping approaches, we confirmed that monocytes do not show significant contribution to tissue macrophages in the steady s... | Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. |
{"1011": 0.21135559678077698, "1014": 0.4067663550376892, "1017": 0.12728634476661682, "1056": 1.04512357711792, "2000": 0.19782574474811554, "2003": 0.03266380727291107, "2006": 0.04674193635582924, "2034": 0.2447827309370041, "2051": 0.4980490207672119, "2064": 0.32905077934265137, "2073": 0.0354953333735466, "2075":... | 12839939 | This paper describes a method for registering and visualizing in real-time the results of transcranial magnetic stimulations (TMS) in physical space on the corresponding anatomical locations in MR images of the brain. The method proceeds in three main steps. First, the patient scalp is digitized in physical space with ... | Registration and real-time visualization of transcranial magnetic stimulation with 3-D MR images |
{"1040": 0.2822965085506439, "1044": 0.6654226183891296, "1052": 0.43623676896095276, "2003": 0.14518201351165771, "2004": 0.13499516248703003, "2005": 0.25995752215385437, "2011": 0.016465263441205025, "2024": 0.1710275560617447, "2029": 0.09495500475168228, "2050": 0.9287132620811462, "2065": 1.049919843673706, "2109... | 12866641 | Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates inordinately high interstitial fluid pressures (IFPs), exceeding those previously measured or theorized for solid tumors, and induces vascular collapse, while present... | Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. |
{"1003": 0.1994270235300064, "1011": 0.13670019805431366, "1013": 0.22704219818115234, "1014": 0.38174858689308167, "1045": 0.04487626627087593, "1048": 0.4190443754196167, "1050": 0.2607102394104004, "1166": 0.2223619967699051, "1997": 0.022212404757738113, "2007": 0.5838727951049805, "2029": 0.25239890813827515, "206... | 12869200 | We performed this meta-analysis of epidemiologic studies to investigate the associations between circulating adiponectin, leptin and adiponectin-leptin (A/L) ratio and endometrial cancer risk. Relevant manuscripts were identified by searching PubMed and ISI Web of Science databases as well as by manual searching the re... | Circulating adiponectin, leptin and adiponectin-leptin ratio and endometrial cancer risk: Evidence from a meta-analysis of epidemiologic studies. |
{"1011": 0.5092619061470032, "1015": 0.6674286723136902, "1039": 0.4914994537830353, "1999": 0.11951763927936554, "2005": 0.151916041970253, "2007": 0.20580662786960602, "2008": 0.053244512528181076, "2011": 0.29981520771980286, "2028": 0.3662964701652527, "2029": 0.3141832649707794, "2046": 0.41389304399490356, "2060"... | 12871002 | We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1 localizes specifically to mitotic chromosomes in embryos. This localization requires the RdRP EGO-1, which physically interacts with CDE-1, and the Argonaute prote... | CDE-1 Affects Chromosome Segregation through Uridylation of CSR-1-Bound siRNAs |
{"1011": 0.06337817758321762, "1040": 0.5404602885246277, "1048": 0.5086748600006104, "1056": 1.133164644241333, "1996": 0.1751343309879303, "2011": 0.3325583338737488, "2028": 0.004870930220931768, "2029": 0.23247487843036652, "2034": 0.22782009840011597, "2076": 0.20580662786960602, "2080": 0.21372433006763458, "2083... | 12871281 | The reorientation of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell enables the directional secretion of cytokines and lytic factors. By single-cell photoactivation of the T cell antigen receptor, we show that MTOC polarization is driven by localized accumulation of diacylglycerol (D... | Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells |
{"1011": 0.043007105588912964, "1039": 0.35950297117233276, "1048": 0.3723714053630829, "1052": 0.10555581003427505, "2008": 0.04113444685935974, "2013": 0.03831886500120163, "2015": 0.08064348995685577, "2029": 0.23402166366577148, "2046": 0.3012613356113434, "2050": 1.0960047245025635, "2063": 0.10379679501056671, "2... | 12880573 | The plcA gene of Listeria monocytogenes encodes a secreted phosphatidylinositol-specific phospholipase C (Pl-PLC). Recent studies have established that transposon mutations within plcA result in avirulence for mice and pleiotropic effects when examined in tissue-culture models of infection. Genetic analysis reveals tha... | Dual roles of plcA in Listeria monocytogenes pathogenesis. |
{"1011": 0.27342069149017334, "1038": 0.4286321699619293, "1997": 0.004870930220931768, "1999": 0.06429435312747955, "2007": 0.30486753582954407, "2008": 0.03925827145576477, "2011": 0.056018441915512085, "2012": 0.32270604372024536, "2029": 0.3388410806655884, "2043": 0.12728634476661682, "2044": 0.129004567861557, "2... | 12881593 | Clp-controlled proteolysis in Bacillus subtilis seems to play a substantial role, particularly under stress conditions. Calibrated Western blot analyses were used to estimate the approximate numbers of heat-inducible Clp molecules within a single cell. According to these numbers, the different Clp ATPases do not seem t... | Fine-tuning in regulation of Clp protein content in Bacillus subtilis. |
{"1011": 0.3005385100841522, "1015": 0.3464667797088623, "1039": 0.46853771805763245, "1050": 0.09050461649894714, "1057": 0.23787821829319, "1059": 1.149384617805481, "2003": 0.1946154683828354, "2005": 0.020300358533859253, "2007": 0.37640097737312317, "2008": 0.16690383851528168, "2011": 0.27044451236724854, "2029":... | 12885341 | West Nile virus (WNV) is the most common arthropod-borne flavivirus in the United States; however, the vector ligand(s) that participate in infection are not known. We now show that an Aedes aegypti C-type lectin, mosGCTL-1, is induced by WNV, interacts with WNV in a calcium-dependent manner, and facilitates infection ... | A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes |
{"1011": 0.0038986403960734606, "1017": 0.46670228242874146, "1043": 0.7153595685958862, "1044": 0.669430673122406, "1047": 0.9864287376403809, "1048": 0.37640097737312317, "1052": 0.306306391954422, "2007": 0.2478361576795578, "2008": 0.07612881064414978, "2010": 0.9060825705528259, "2023": 0.011650617234408855, "2029... | 12887068 | Over 70% of diffuse intrinsic pediatric gliomas, an aggressive brainstem tumor, harbor heterozygous mutations that create a K27M amino acid substitution (methionine replaces lysine 27) in the tail of histone H3.3. The role of the H3.3K27M mutation in tumorigenesis is not fully understood. Here, we use a human embryonic... | Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation |
{"1011": 0.021256839856505394, "1040": 0.04674193635582924, "1044": 0.11430477350950241, "1054": 0.14179791510105133, "1997": 0.012615402229130268, "2003": 0.10467668622732162, "2005": 0.2852376699447632, "2007": 0.18816383183002472, "2008": 0.06154331564903259, "2012": 0.013579257763922215, "2029": 0.40220460295677185... | 12892137 | Human Rad51 (hRad51), a member of a conserved family of general recombinases, is shown here to have an avid capability to make DNA joints between homologous DNA molecules and promote highly efficient DNA strand exchange of the paired molecules over at least 5.4 kilobase pairs. Furthermore, maximal efficiency of homolog... | Basis for avid homologous DNA strand exchange by human Rad51 and RPA. |
{"1011": 0.5057345628738403, "1016": 0.08692999184131622, "1040": 1.1462857723236084, "1041": 0.09050461649894714, "1574": 0.495672345161438, "1999": 0.26446542143821716, "2004": 0.007782140281051397, "2007": 0.0174254160374403, "2020": 0.014542185701429844, "2048": 0.25088030099868774, "2052": 0.10467668622732162, "20... | 12899460 | BACKGROUND The Euro-D depression scale consists of symptom clusters that may be differentially related to demographic and cognitive characteristics in older adults. This hypothesis needs further investigation and the role of measurement bias on substantive conclusions remains to be established. METHOD The study sample ... | A multiple indicators multiple causes model of late-life depression in Latin American countries |
{"1011": 0.31132611632347107, "1014": 0.018384648486971855, "1044": 0.1011524572968483, "2005": 0.255429208278656, "2007": 0.13071982562541962, "2011": 0.37304413318634033, "2015": 0.9739698171615601, "2020": 0.0842406153678894, "2029": 0.27564704418182373, "2033": 0.8161250352859497, "2038": 0.004870930220931768, "204... | 12899612 | Although mesenchymal stem cells (MSCs) have been increasingly trialed to treat a variety of diseases, the underlying mechanisms remain still elusive. In this study, human umbilical cord (UC)-derived MSCs were stimulated by hypoxia, and the membrane microvesicles (MVs) in the supernatants were collected by ultracentrifu... | Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo. |
{"1011": 0.07068414986133575, "1019": 0.10906458646059036, "1038": 0.18167030811309814, "1040": 0.3005385100841522, "1043": 0.567951500415802, "1044": 0.3683255612850189, "1048": 0.12384103983640671, "1050": 0.24554696679115295, "1051": 0.15610189735889435, "2004": 0.5483922958374023, "2007": 0.22548456490039825, "2026... | 12903921 | It has been proved that oxidative stress increases when leukemia is accompanied by depression. This fact may indicate the role of oxidative stress in the development of depression in cancer patients. The aim of this study was to determine whether the acute myeloid leukemia of Brown Norway rats, which is accompanied by ... | Evaluation of oxidative status and depression-like responses in Brown Norway rats with acute myeloid leukemia |
{"1011": 0.021256839856505394, "1015": 0.014542185701429844, "1037": 0.015504186972975731, "1043": 0.3949938118457794, "1044": 0.11081436276435852, "1047": 0.22001366317272186, "1049": 0.09672962874174118, "1052": 0.8861536383628845, "1054": 0.8682814836502075, "2003": 0.0058422754518687725, "2011": 0.3757305145263672,... | 12909503 | DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage checkpoint systems cause cell cycle arrest, promote repair and induce programed cell death when damage is severe. Checkpoints are critical parts of the DNA damage response network that act to sup... | Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress |
{"1011": 0.4248080551624298, "1015": 0.13670019805431366, "1018": 0.7276995778083801, "1043": 1.2894693613052368, "1044": 0.1889725625514984, "1051": 0.19622190296649933, "1052": 0.8315495252609253, "1055": 0.3757305145263672, "1997": 0.12642613053321838, "2002": 0.6573580503463745, "2003": 0.0174254160374403, "2006": ... | 12922760 | BACKGROUND G-quadruplexes (G4s) are stable non-canonical DNA secondary structures consisting of stacked arrays of four guanines, each held together by Hoogsteen hydrogen bonds. Sequences with the ability to form these structures in vitro, G4 motifs, are found throughout bacterial and eukaryotic genomes. The budding yea... | The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage |
{"1009": 0.07341018319129944, "1011": 0.0913962796330452, "1017": 0.08603433519601822, "1021": 0.6102113127708435, "1040": 0.2852376699447632, "1059": 1.094698429107666, "1998": 0.03925827145576477, "2005": 0.010684899985790253, "2011": 0.1693800985813141, "2029": 0.1889725625514984, "2033": 0.574020504951477, "2048": ... | 12932176 | The balance between excitatory and inhibitory synapses is crucial for normal brain function. Wnt proteins stimulate synapse formation by increasing synaptic assembly. However, it is unclear whether Wnt signaling differentially regulates the formation of excitatory and inhibitory synapses. Here, we demonstrate that Wnt7... | Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II. |
{"1016": 0.45994341373443604, "1043": 0.9900637865066528, "1056": 0.841701865196228, "1059": 0.6291293501853943, "1155": 0.5080875158309937, "1999": 0.016465263441205025, "2003": 0.33115679025650024, "2007": 0.04487626627087593, "2011": 0.32341301441192627, "2013": 0.01934296265244484, "2015": 0.01934296265244484, "202... | 12943966 | Ghrelin is a hunger hormone with gastroprokinetic properties but the factors controlling ghrelin secretion from the stomach are unknown. Bitter taste receptors (T2R) and the gustatory G proteins, α-gustducin (gust) and α-transducin, are expressed in the gut and are involved in the chemosensation of nutrients. This stud... | Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. |
{"1009": 0.7656494975090027, "1011": 0.20580662786960602, "1016": 0.1693800985813141, "1043": 0.8298473954200745, "2005": 0.13243216276168823, "2011": 0.5651806592941284, "2012": 0.09317722171545029, "2029": 0.1808556467294693, "2050": 0.7163142561912537, "2058": 0.1718502640724182, "2076": 0.08961215615272522, "2079":... | 12948892 | Evidence has been accumulated that glioblastoma cells release and exploit glutamate for proliferation and migration by autocrine or paracrine loops through Ca2+-permeable AMPA-type glutamate receptors. Here, we show that Ca2+ signaling mediated by AMPA receptor regulates the growth and motility of glioblastoma cells vi... | Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. |
{"1011": 0.33675122261047363, "1038": 0.8633513450622559, "1043": 0.7370892763137817, "1050": 0.3897167444229126, "1998": 0.2763880789279938, "2003": 0.011650617234408855, "2007": 0.22704219818115234, "2011": 0.17922431230545044, "2015": 0.12556517124176025, "2029": 0.021256839856505394, "2033": 0.40611594915390015, "2... | 12956194 | Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding to intracellular signaling. Activation of class B G protein-coupled receptors i... | The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism |
{"1011": 0.2478361576795578, "1016": 0.401551216840744, "1018": 0.3560888469219208, "1022": 0.3916989266872406, "1039": 0.20022670924663544, "1048": 0.09228714555501938, "1056": 0.7389566898345947, "1996": 0.06337817758321762, "1999": 0.15610189735889435, "2005": 0.28743788599967957, "2008": 0.06795065850019455, "2011"... | 12966719 | CD8 tissue-resident memory T (TRM) cells provide efficient local control of viral infection, but the role of CD4 TRM is less clear. Here, by using parabiotic mice, we show that a preexisting pool of CD4 TRM cells in the genital mucosa was required for full protection from a lethal herpes simplex virus 2 (HSV-2) infecti... | A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells |
{"1003": 0.15777134895324707, "1014": 0.5584990978240967, "1022": 0.06337817758321762, "1051": 0.47158926725387573, "1052": 0.8583967685699463, "1058": 0.3963087201118469, "1999": 0.08692999184131622, "2007": 0.058784693479537964, "2012": 0.0029254043474793434, "2028": 0.2659635543823242, "2029": 0.020300358533859253, ... | 12991445 | OBJECTIVE To determine the effects of smoking, plasma lipids, lipoproteins, apolipoproteins, and fibrinogen on the patency of saphenous vein femoropopliteal bypass grafts at one year. DESIGN Prospective study of patients with saphenous vein femoropopliteal bypass grafts entered into a multicentre trial. SETTING Surgica... | Influence of smoking and plasma factors on patency of femoropopliteal vein grafts. |
{"1020": 0.4462870955467224, "1038": 0.47463157773017883, "1039": 0.22392450273036957, "1041": 0.3723714053630829, "1053": 0.07250232994556427, "1054": 0.12384103983640671, "1999": 0.0029254043474793434, "2007": 0.016465263441205025, "2012": 0.4374985992908478, "2025": 0.09317722171545029, "2044": 0.06337817758321762, ... | 12994780 | Rationale:Atypical antipsychotic drugs (AAD) induce significant weight gain in female C57BL/6J mice. The effect of dietary fat on weight gain and serum lipids in this model is unknown. Objectives: Test the hypothesis that the obesigenic effects of these drugs are greater in the presence of a high-fat diet. Methods:Fema... | No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs |
{"1054": 0.043007105588912964, "1060": 0.36086538434028625, "2003": 0.40546512603759766, "2011": 0.10906458646059036, "2022": 0.05417001247406006, "2054": 0.10555581003427505, "2064": 0.04953393340110779, "2076": 0.4855078160762787, "2128": 1.0409941673278809, "2129": 0.030771657824516296, "2339": 0.24325250089168549, ... | 13000926 | Cold injury is a tissue trauma produced by exposure to freezing temperatures and even brief exposure to a severely cold and windy environment. Rewarming of frozen tissue is associated with blood reperfusion and the simultaneous generation of free oxygen radicals. In this review is discussed the current understanding of... | The role of free radicals in cold injuries. |
{"1011": 0.06977381557226181, "1015": 0.5773153901100159, "1016": 0.574020504951477, "1037": 0.014542185701429844, "1056": 0.6296497583389282, "2028": 0.29473719000816345, "2029": 0.09050461649894714, "2031": 0.07159364968538284, "2033": 0.22859740257263184, "2038": 0.02887592278420925, "2048": 0.24325250089168549, "20... | 13001323 | Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical importance. Here, we show that mice lacking SIRT1 in steroidogenic factor 1 (... | SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. |
{"1011": 0.10731173306703568, "1018": 0.10906458646059036, "2002": 1.1038070917129517, "2005": 0.04394211992621422, "2008": 0.11778303235769272, "2010": 0.10026945173740387, "2011": 0.4450363218784332, "2029": 0.259204238653183, "2033": 0.5729197263717651, "2099": 0.4926934838294983, "2109": 0.045809537172317505, "2182... | 13002003 | Despite the recent identification of the transcriptional regulatory circuitry involving SOX2, NANOG, and OCT-4, the intracellular signaling networks that control pluripotency of human embryonic stem cells (hESCs) remain largely undefined. Here, we demonstrate an essential role for the serine/threonine protein kinase ma... | mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells. |
{"1011": 0.09050461649894714, "1014": 0.38574060797691345, "1017": 0.43938836455345154, "1019": 0.6155022978782654, "1020": 0.4794800877571106, "1023": 0.5718178153038025, "1052": 0.6960725784301758, "1055": 0.7305257320404053, "1056": 0.5668440461158752, "2007": 0.04487626627087593, "2011": 0.19381128251552582, "2015"... | 13007205 | Stromal fibroblasts can contribute to tumor invasion through the release of matrix metalloproteinases (MMPs). Population studies have suggested that single nucleotide polymorphisms (SNPs) in MMP genes influence levels of expression and may be associated with breast cancer risk and with disease progression. This study d... | Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion |
{"1020": 0.5174443125724792, "1996": 0.014542185701429844, "1997": 0.4734157919883728, "2015": 0.6654226183891296, "2024": 0.07431721687316895, "2037": 0.055094651877880096, "2048": 0.28450319170951843, "2054": 0.2837681770324707, "2076": 0.23710809648036957, "2079": 0.22079704701900482, "2097": 0.053244512528181076, "... | 13011249 | The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell d... | Hallmarks of Cancer: The Next Generation |
{"1011": 0.25694093108177185, "1038": 0.1693800985813141, "1043": 0.16607704758644104, "1048": 0.1011524572968483, "1049": 0.014542185701429844, "1055": 0.2539152204990387, "2006": 0.678885817527771, "2011": 0.2247048318386078, "2029": 0.3416208028793335, "2057": 0.4145384132862091, "2076": 0.20102575421333313, "2099":... | 13023410 | The oncogenic BCR/ABL tyrosine kinase induces constitutive DNA damage in Philadelphia chromosome (Ph)-positive leukemia cells. We find that BCR/ABL-induced reactive oxygen species (ROSs) cause chronic oxidative DNA damage resulting in double-strand breaks (DSBs) in S and G(2)/M cell cycle phases. These lesions are repa... | BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. |
{"1014": 0.15023678541183472, "1060": 0.8091925978660583, "1997": 0.12728634476661682, "2012": 0.2531573474407196, "2022": 0.05046287178993225, "2053": 0.32199856638908386, "2058": 0.15275461971759796, "2064": 0.04674193635582924, "2070": 0.0317181795835495, "2071": 0.16524957120418549, "2087": 0.2689530849456787, "209... | 13025574 | High doses of ionizing radiation clearly produce deleterious consequences in humans, including, but not exclusively, cancer induction. At very low radiation doses the situation is much less clear, but the risks of low-dose radiation are of societal importance in relation to issues as varied as screening tests for cance... | Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. |
{"1014": 0.34508460760116577, "1019": 0.016465263441205025, "1039": 0.13499516248703003, "1040": 0.46117570996284485, "1041": 0.2317005842924118, "1043": 0.28155985474586487, "1052": 0.45870962738990784, "1053": 0.1873544454574585, "1065": 0.021256839856505394, "2003": 0.2696990668773651, "2051": 0.08961215615272522, "... | 13027590 | CONTEXT Chronic pelvic pain is a common condition with a major effect on health-related quality of life, work productivity, and health care use. Operative interruption of nerve trunks in the uterosacral ligaments by laparoscopic uterosacral nerve ablation (LUNA) is a treatment option for patients with chronic pelvic pa... | Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial. |
{"1048": 0.08603433519601822, "1052": 0.5080875158309937, "2002": 0.04207121208310127, "2004": 0.0797421783208847, "2005": 0.30486753582954407, "2029": 0.13499516248703003, "2039": 0.04207121208310127, "2050": 0.2089812457561493, "2063": 0.08064348995685577, "2064": 0.21687394380569458, "2079": 0.11604541540145874, "20... | 13030852 | Plasma alkaline phosphatase isoenzyme activities were determined in patients with breast cancer to diagnose and monitor bone and liver metastases. Bone alkaline phosphatase activity was increased in 21 of 50 patients (42%) with radiologically confirmed bone metastases, while total alkaline phosphatase activity was incr... | Identification of bone and liver metastases from breast cancer by measurement of plasma alkaline phosphatase isoenzyme activity. |
{"1037": 0.11778303235769272, "1038": 0.23247487843036652, "1998": 0.04113444685935974, "2000": 0.22079704701900482, "2003": 0.021256839856505394, "2004": 0.4531385898590088, "2005": 0.026976587250828743, "2022": 0.151916041970253, "2064": 0.2576959431171417, "2073": 0.29473719000816345, "2079": 0.05694137513637543, "2... | 13031967 | The use of biotechnology-derived medicines has significantly increased in recent decades. Although biosimilars undergo rigorous characterization as well as clinical studies to document their safety and effectiveness, they are highly complex molecules and small changes in the purification and production process of a bio... | Recommendations on how to ensure the safety and effectiveness of biosimilars in Latin America: a point of view |
{"1011": 0.004870930220931768, "1015": 0.03266380727291107, "1018": 0.48430517315864563, "1049": 0.10379679501056671, "1051": 0.17840765416622162, "1055": 0.3588210940361023, "1056": 0.12642613053321838, "1999": 0.06429435312747955, "2000": 0.11081436276435852, "2004": 0.10291612148284912, "2005": 0.176772341132164, "2... | 13036442 | A yeast strain lacking Met4p, the primary transcriptional regulator of the sulfur assimilation pathway, cannot synthesize methionine. This apparently simple auxotroph did not grow well in rich media containing excess methionine, forming small colonies on yeast extract/peptone/dextrose plates. Faster-growing large colon... | Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast |
{"1013": 0.37907835841178894, "1046": 0.9455460906028748, "2000": 0.11865071207284927, "2001": 0.13157635927200317, "2013": 0.1064341589808464, "2023": 0.08154398202896118, "2047": 0.37102460861206055, "2054": 0.15442965924739838, "2058": 0.055094651877880096, "2075": 0.0029254043474793434, "2106": 0.036437395960092545... | 13042119 | This glossary was developed to provide technical references to support work in the field of the alternatives to animal testing. It was compiled from various existing reference documents coming from different sources and is meant to be a point of reference on alternatives to animal testing. Giving the ever-increasing nu... | Glossary of reference terms for alternative test methods and their validation. |
{"1009": 0.33953672647476196, "1011": 0.31845372915267944, "1015": 0.10467668622732162, "1018": 0.20501139760017395, "1043": 0.3241194784641266, "1048": 0.6170841455459595, "1056": 1.102510929107666, "2002": 0.38441169261932373, "2007": 0.23864774405956268, "2011": 0.11430477350950241, "2012": 0.03831886500120163, "202... | 13048272 | Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1, LMO2, GA... | Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. |
{"1016": 0.18654440343379974, "1020": 0.1619328260421753, "1998": 0.0174254160374403, "2007": 0.33953672647476196, "2011": 0.09938567131757736, "2014": 0.09584271162748337, "2029": 0.2478361576795578, "2035": 0.2990913391113281, "2064": 0.2918238639831543, "2075": 0.0019512200960889459, "2077": 0.6739205718040466, "207... | 13069283 | BACKGROUND Estrogen receptor-positive breast cancer tumors depend on estrogen signaling for their growth and replication and can be treated by anti-estrogen therapy with tamoxifen. Polymorphisms of the CYP2D6 and CYP2C19 genes are associated with an impaired response to tamoxifen. The study objective was to investigate... | Influence of CYP2D6 Polymorphisms on Serum Levels of Tamoxifen Metabolites in Spanish Women with Breast Cancer |
{"1011": 0.058784693479537964, "1048": 0.5133614540100098, "1056": 0.5816917419433594, "1061": 1.036847710609436, "2003": 0.3750596046447754, "2004": 0.7076893448829651, "2005": 0.176772341132164, "2011": 0.42735910415649414, "2029": 0.08782484382390976, "2039": 0.0913962796330452, "2046": 0.3019835948944092, "2050": 0... | 13070316 | Tumor angiogenesis is an essential process for supplying rapidly growing malignant tissues with essential nutrients and oxygen. An angiogenic switch allows tumor cells to survive and grow, and provides them access to vasculature resulting in metastatic disease. Monocyte-derived macrophages recruited and reprogrammed by... | Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis |
{"1003": 0.06429435312747955, "1018": 0.26820653676986694, "1020": 0.11430477350950241, "1061": 0.6096806526184082, "1997": 0.11865071207284927, "2000": 0.11430477350950241, "2005": 0.14349138736724854, "2006": 0.13499516248703003, "2007": 0.10467668622732162, "2022": 0.16607704758644104, "2035": 0.4531385898590088, "2... | 13071728 | BACKGROUND The World Health Organization (WHO) released revised guidelines in 2015 recommending that all people living with HIV, regardless of CD4 count, initiate antiretroviral therapy (ART) upon diagnosis. However, few studies have projected the global resources needed for rapid scale-up of ART. Under the Health Poli... | The HIV Treatment Gap: Estimates of the Financial Resources Needed versus Available for Scale-Up of Antiretroviral Therapy in 97 Countries from 2015 to 2020 |
{"1011": 0.15610189735889435, "1016": 0.5080875158309937, "1020": 0.05970508232712746, "1052": 0.18978065252304077, "1054": 0.7182208299636841, "1056": 0.1212492436170578, "1998": 0.0797421783208847, "1999": 0.011650617234408855, "2008": 0.11256109178066254, "2011": 0.38308101892471313, "2026": 0.37371641397476196, "20... | 13072112 | A number of proteins and drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, but the factors that govern the elongation rate (nucleotide additions per min) and processivity (nucleotide additions per initiation event) in vivo are poorly understood. Here, we show that a mut... | Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo. |
{"1011": 0.018384648486971855, "1012": 0.037378571927547455, "1039": 0.7305257320404053, "1040": 0.006812678650021553, "1041": 0.4568560719490051, "2003": 0.4794800877571106, "2005": 0.1477125883102417, "2015": 0.4818955361843109, "2024": 0.20818853378295898, "2025": 0.10906458646059036, "2041": 0.06703783571720123, "2... | 13072113 | Caenorhabditis elegans is a powerful model for analysis of the conserved mechanisms that modulate healthy aging. In the aging nematode nervous system, neuronal death and/or detectable loss of processes are not readily apparent, but because dendrite restructuring and loss of synaptic integrity are hypothesized to contri... | Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system. |
{"1014": 0.2719337046146393, "1998": 0.0174254160374403, "2051": 0.21135559678077698, "2082": 1.070887804031372, "2109": 0.2990913391113281, "2111": 0.09406650811433792, "2120": 0.1873544454574585, "2137": 0.006812678650021553, "2142": 0.23324857652187347, "2147": 0.058784693479537964, "2149": 0.45251765847206116, "215... | 13083189 | OBJECTIVES Despite recognition of the important influence of environmental determinants on physical activity patterns, minimal empirical research has been done to assess the impact of environmental/contextual determinants of physical activity. This article aims to investigate environmental and sociodemographic determin... | Determinants of adolescent physical activity and inactivity patterns. |
{"1017": 0.1064341589808464, "1050": 0.4462870955467224, "2000": 0.06795065850019455, "2001": 0.12038381397724152, "2004": 0.3683255612850189, "2005": 0.08782484382390976, "2012": 0.637939989566803, "2020": 0.10993985831737518, "2038": 0.10203468054533005, "2043": 0.1905880719423294, "2060": 0.29109421372413635, "2062"... | 13097856 | CONTEXT In 2002, an estimated 877,000 lives were lost worldwide through suicide. Some developed nations have implemented national suicide prevention plans. Although these plans generally propose multiple interventions, their effectiveness is rarely evaluated. OBJECTIVES To examine evidence for the effectiveness of spec... | Suicide prevention strategies: a systematic review. |
{"1011": 0.13925230503082275, "1022": 1.1121915578842163, "1048": 0.15860503911972046, "1051": 0.2018241584300995, "2005": 0.13157635927200317, "2029": 0.011650617234408855, "2049": 0.06703783571720123, "2064": 0.13243216276168823, "2065": 0.5579402446746826, "2076": 0.40806588530540466, "2078": 0.2711893916130066, "20... | 13106686 | Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxid... | Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. |
{"1011": 0.11256109178066254, "1023": 0.20102575421333313, "1048": 0.30989447236061096, "1051": 0.6430866718292236, "1054": 0.3810817003250122, "1056": 0.5860490798950195, "1059": 0.04674193635582924, "2007": 0.09672962874174118, "2029": 0.15275461971759796, "2058": 0.5838727951049805, "2066": 0.08154398202896118, "207... | 13108582 | Osteopontin (OPN), a key component of the extracellular matrix, is associated with the fibrotic process during tissue remodeling. OPN and the cytokine interleukin (IL)-18 have been shown to be overexpressed in an array of human cardiac pathologies. In the present study, we determined the role of IL-18 in the regulation... | IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice. |
{"1011": 0.10203468054533005, "1044": 0.255429208278656, "2002": 0.14433705806732178, "2003": 0.0842406153678894, "2015": 0.3177432417869568, "2028": 0.31489628553390503, "2029": 0.05139094591140747, "2031": 0.06977381557226181, "2035": 0.3388410806655884, "2046": 0.3423145115375519, "2062": 0.22937409579753876, "2069"... | 13116880 | The mammalian blood system, containing more than 10 distinct mature cell types, stands on one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess the ability of both multipotency and self-renewal. Multipotency is the ability to differentiate into all functional blood cells. Self-rene... | Hematopoietic stem cell: self-renewal versus differentiation. |
{"1011": 0.49030399322509766, "1053": 0.0770333781838417, "1055": 0.10467668622732162, "2003": 0.17759032547473907, "2005": 0.004870930220931768, "2007": 0.025073638185858727, "2015": 0.21530038118362427, "2022": 0.029824240133166313, "2025": 0.029824240133166313, "2060": 0.23402166366577148, "2063": 0.2539152204990387... | 13123189 | BACKGROUND RNA-Seq is revolutionizing the way transcript abundances are measured. A key challenge in transcript quantification from RNA-Seq data is the handling of reads that map to multiple genes or isoforms. This issue is particularly important for quantification with de novo transcriptome assemblies in the absence o... | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome |
{"1011": 0.1913948506116867, "1016": 0.1384023278951645, "1037": 0.05786345899105072, "1041": 0.043007105588912964, "1996": 0.10379679501056671, "1998": 0.4873090982437134, "2039": 0.05970508232712746, "2048": 0.650757372379303, "2057": 0.036437395960092545, "2064": 0.06337817758321762, "2066": 0.2539152204990387, "207... | 13135544 | We have constructed a synthetic ecosystem consisting of two Escherichia coli populations, which communicate bi-directionally through quorum sensing and regulate each other's gene expression and survival via engineered gene circuits. Our synthetic ecosystem resembles canonical predator-prey systems in terms of logic and... | A synthetic Escherichia coli predator–prey ecosystem |
{"1037": 0.23015019297599792, "1040": 0.5370414853096008, "1041": 0.014542185701429844, "1048": 0.11256109178066254, "1051": 0.22157983481884003, "1999": 0.15442965924739838, "2001": 0.2531573474407196, "2003": 0.11865071207284927, "2005": 0.15275461971759796, "2008": 0.10026945173740387, "2012": 0.07341018319129944, "... | 13162391 | A funnel trap that fitted over holes leading into hollow trees was used to capture adult phlebotomine sand flies, Lutzomyia shannoni Dyar, on Ossabaw Island, Chatham County, Ga. These insects rested in hollow trees during the day and were collected by funnel traps as they egressed from the tree holes at night. The trap... | Funnel trap for the capture of phlebotomine sand flies (Diptera: Psychodidae) from tree holes. |
{"1011": 0.02412080205976963, "1017": 0.3325583338737488, "1041": 0.19782574474811554, "1043": 0.6389714479446411, "1050": 0.5903874635696411, "1060": 1.2358801364898682, "2004": 0.007782140281051397, "2007": 0.2317005842924118, "2011": 0.24171993136405945, "2013": 0.14518201351165771, "2029": 0.17922431230545044, "203... | 13172737 | Withdrawal from chronic cocaine reduces extracellular glutamate levels in the nucleus accumbens by decreasing cystine/glutamate exchange (xc-). Activating xc- with N-acetylcysteine restores extracellular glutamate and prevents cocaine-induced drug seeking. It was hypothesized that the activation of xc- prevents drug se... | Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. |
{"1011": 0.32553088665008545, "1998": 0.052318159490823746, "2004": 0.11778303235769272, "2007": 0.011650617234408855, "2012": 0.3416208028793335, "2029": 0.016465263441205025, "2039": 0.32129061222076416, "2051": 1.0423725843429565, "2058": 0.9115922451019287, "2061": 0.3784096837043762, "2064": 0.21922965347766876, "... | 13179318 | In traditional Kaplan-Meier or Cox regression analysis, usually a risk factor measured at baseline is related to mortality thereafter. During follow-up, however, things may change: either the effect of a fixed baseline risk factor may vary over time, resulting in a weakening or strengthening of associations over time, ... | Survival analysis: time-dependent effects and time-varying risk factors. |
{"1011": 0.11951763927936554, "1015": 0.7370892763137817, "1050": 0.35677260160446167, "1054": 0.18654440343379974, "2003": 0.18329764902591705, "2008": 0.24018502235412598, "2028": 0.304147332906723, "2029": 0.3615458607673645, "2078": 0.45499902963638306, "2098": 0.4286321699619293, "2239": 0.49864232540130615, "2290... | 13189693 | Neuregulin 1 (NRG1) is a secreted trophic factor that activates the postsynaptic erbB4 receptor tyrosine kinase. Both NRG1 and erbB4 have been repeatedly associated with schizophrenia, but their downstream targets are not well characterized. ErbB4 is highly abundant in interneurons, and NRG1-mediated erbB4 activation h... | Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition |
{"1011": 0.28670501708984375, "1014": 0.23864774405956268, "1047": 0.06337817758321762, "1048": 0.32270604372024536, "1049": 0.2576959431171417, "1052": 0.25088030099868774, "2000": 0.13670019805431366, "2007": 0.2478361576795578, "2026": 0.8143964409828186, "2033": 0.10379679501056671, "2048": 0.16690383851528168, "20... | 13205096 | BACKGROUND In patients with acute myeloid leukemia (AML), the presence or absence of recurrent cytogenetic aberrations is used to identify the appropriate therapy. However, the current classification system does not fully reflect the molecular heterogeneity of the disease, and treatment stratification is difficult, esp... | Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. |
{"1020": 0.3027053773403168, "1022": 0.1477125883102417, "1039": 0.15693697333335876, "1042": 0.2247048318386078, "1044": 0.5370414853096008, "1045": 0.020300358533859253, "1051": 0.401551216840744, "1052": 0.7028654217720032, "1053": 0.015504186972975731, "1059": 0.3519764244556427, "1997": 0.29255300760269165, "1998"... | 13205803 | The Centers for Disease Control and Prevention Office of Workforce and Career Development is committed to developing a competent, sustainable, and diverse public health workforce through evidence-based training, career and leadership development, and strategic workforce planning to improve population health outcomes. T... | Perspectives on public health workforce research. |
{"1042": 0.2561853528022766, "1062": 1.1653456687927246, "2003": 0.3547199070453644, "2005": 0.02887592278420925, "2011": 0.2516399025917053, "2046": 0.42608439922332764, "2054": 0.13157635927200317, "2064": 0.16110190749168396, "2075": 0.37304413318634033, "2078": 0.8925741910934448, "2079": 0.1946154683828354, "2109"... | 13221399 | The ability to achieve site-specific manipulation of the mammalian genome has widespread implications for basic and applied research. Gene targeting is a process in which a DNA molecule introduced into a cell replaces the corresponding chromosomal segment by homologous recombination, and thus presents a precise way to ... | Gene targeting using zinc finger nucleases |
{"1011": 0.4537591338157654, "1012": 0.03831886500120163, "1013": 0.28450319170951843, "1018": 0.47158926725387573, "1041": 0.19220098853111267, "1053": 0.03266380727291107, "1054": 0.18978065252304077, "1059": 0.2918238639831543, "1062": 0.10291612148284912, "2000": 0.2160874605178833, "2003": 0.255429208278656, "2005... | 13223806 | Real-time reverse transcription followed by polymerase chain reaction (RT-PCR) is the most suitable method for the detection and quantification of mRNA. It offers high sensitivity, good reproducibility and a wide quantification range. Today, relative expression is increasingly used, where the expression of a target gen... | relative expression results in real-time |
{"1003": 0.2607102394104004, "1014": 0.28743788599967957, "1040": 0.18816383183002472, "2007": 0.175953671336174, "2015": 0.20739519596099854, "2030": 0.004870930220931768, "2044": 0.6441128253936768, "2051": 0.12728634476661682, "2064": 0.13499516248703003, "2067": 0.5336109399795532, "2076": 0.06154331564903259, "209... | 13223957 | OBJECTIVE The cardinal indication for surgical treatment of gallstones is pain attacks. However, following cholecystectomy, 20% of patients remain symptomatic. It is unclear to what extent post-cholecystectomy symptoms can be ascribed to persistence of preoperative symptoms or to new pathology. The pain and digestive p... | Pain attacks in non-complicated and complicated gallstone disease have a characteristic pattern and are accompanied by dyspepsia in most patients: the results of a prospective study. |
{"1003": 0.04953393340110779, "1039": 0.1734936386346817, "1052": 0.13499516248703003, "1053": 0.03360854089260101, "1057": 0.5127768516540527, "1058": 0.055094651877880096, "2020": 0.08513788133859634, "2035": 0.012615402229130268, "2042": 0.02887592278420925, "2058": 0.5116065740585327, "2072": 0.07884006202220917, "... | 13230773 | CONTEXT Population surveys indicate that physical activity levels are low in the United States. One consequence of inactivity, low cardiorespiratory fitness, is an established risk factor for cardiovascular disease (CVD) morbidity and mortality, but the prevalence of cardiorespiratory fitness has not been quantified in... | Prevalence and cardiovascular disease correlates of low cardiorespiratory fitness in adolescents and adults. |
{"1009": 0.8135309815406799, "1011": 0.014542185701429844, "1017": 0.2160874605178833, "1022": 0.659380316734314, "1039": 0.2837681770324707, "1040": 0.05970508232712746, "1048": 0.49864232540130615, "1052": 0.04487626627087593, "1056": 0.6989894509315491, "1999": 0.026025565341114998, "2000": 0.010684899985790253, "20... | 13231899 | Vaccines are largely ineffective for patients with established cancer, as advanced disease requires potent and sustained activation of CD8(+) cytotoxic T lymphocytes (CTLs) to kill tumor cells and clear the disease. Recent studies have found that subsets of dendritic cells (DCs) specialize in antigen cross-presentation... | In situ regulation of DC subsets and T cells mediates tumor regression in mice. |
{"1011": 0.06154331564903259, "1043": 0.6086184978485107, "1044": 0.2516399025917053, "1050": 0.06886265426874161, "1056": 0.4788752794265747, "1058": 0.6989894509315491, "2005": 0.018384648486971855, "2011": 0.3683255612850189, "2022": 0.8332487344741821, "2029": 0.23710809648036957, "2033": 0.7500885725021362, "2038"... | 13235609 | Inhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma multiforme (GBM) and in a subset of GBM patients treated with bevacizumab. Here, we demonstrate that vascular endothelial growth factor (VEGF) directly and negatively regulates tumor cell invasion through enhanced recruitment ... | VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. |
{"1006": 0.0913962796330452, "1011": 0.1751343309879303, "1017": 0.013579257763922215, "1018": 0.10026945173740387, "1056": 0.04207121208310127, "1996": 0.49864232540130615, "1997": 0.1751343309879303, "2005": 0.02887592278420925, "2011": 0.22859740257263184, "2029": 0.25845035910606384, "2034": 0.9100211262702942, "20... | 13242763 | Trophectoderm (TE), the first differentiated cell lineage of mammalian embryogenesis, forms the placenta, a structure unique to mammalian development. The differentiation of TE is a hallmark event in early mammalian development, but molecular mechanisms underlying this first differentiation event remain obscure. Embryo... | Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation |
{"1009": 0.7105726003646851, "1011": 0.41840189695358276, "1015": 0.4831010699272156, "1017": 0.4093637466430664, "1043": 0.7201237678527832, "1050": 0.43875885009765625, "1999": 0.06795065850019455, "2005": 0.07884006202220917, "2007": 0.11256109178066254, "2025": 0.08603433519601822, "2028": 0.2105647772550583, "2029... | 13244602 | CD133+ populations of human glioblastoma multiforme (GBM) cells are reportedly enriched for tumor stem cells (TSCs) or tumor-initiating cells (TICs). Approximately 40% of freshly isolated GBM specimens, however, do not contain CD133+ tumor cells, raising the possibility that CD133 may not be a universal enrichment mark... | SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. |
{"1017": 0.36086538434028625, "1018": 0.29109421372413635, "1056": 0.03831886500120163, "1060": 0.6128603219985962, "2006": 0.0174254160374403, "2008": 0.12556517124176025, "2013": 0.05417001247406006, "2025": 0.5495203733444214, "2029": 0.3325583338737488, "2035": 0.3824150264263153, "2043": 0.04394211992621422, "2053... | 13245542 | We isolated a mutant allele of dnaX, encoding the tau and gamma subunits of the DNA polymerase III holoenzyme, that causes extreme cell filamentation but does not affect either cell growth or DNA replication. This phenotype results from a defect in daughter chromosome decatenation during rapid growth. In these cells, P... | Temporal regulation of topoisomerase IV activity in E. coli. |
{"1013": 0.026976587250828743, "1014": 0.5197699069976807, "1015": 0.07250232994556427, "1016": 0.3499138653278351, "1017": 0.2822965085506439, "1020": 0.14179791510105133, "2001": 0.14939609169960022, "2005": 0.24171993136405945, "2006": 0.28082266449928284, "2007": 0.08154398202896118, "2011": 0.09228714555501938, "2... | 13256155 | BACKGROUND Molecularly targeted agents have been reported to have anti-tumour activity for patients whose tumours harbour the matching molecular alteration. These results have led to increased off-label use of molecularly targeted agents on the basis of identified molecular alterations. We assessed the efficacy of seve... | Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial. |
{"1043": 0.2800849378108978, "1044": 0.0174254160374403, "1996": 0.14602625370025635, "1999": 0.03266380727291107, "2002": 0.823009729385376, "2003": 0.12038381397724152, "2008": 0.043007105588912964, "2011": 0.1401015669107437, "2029": 0.22079704701900482, "2063": 0.1751343309879303, "2075": 0.6578640341758728, "2076"... | 13277039 | The liver contributes to glucose homeostasis by promoting either storage or production of glucose, depending on the physiological state. The cAMP response element-binding protein (CREB) is a principal regulator of genes involved in coordinating the hepatic response to fasting, but its mechanism of gene activation remai... | CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. |
{"1057": 0.22079704701900482, "1998": 0.06337817758321762, "2001": 0.02792670577764511, "2013": 0.25088030099868774, "2020": 0.06703783571720123, "2024": 0.0058422754518687725, "2034": 0.41195443272590637, "2037": 0.026976587250828743, "2038": 0.12986256182193756, "2042": 0.16359257698059082, "2043": 0.1090645864605903... | 13277118 | BACKGROUND Polar bears (Ursus maritimus) are among those species most susceptible to the rapidly changing arctic climate, and their survival is of global concern. Despite this, little is known about polar bear species history. Future conservation strategies would significantly benefit from an understanding of basic evo... | Ancient Hybridization and an Irish Origin for the Modern Polar Bear Matriline |
{"1011": 0.21922965347766876, "1021": 0.7426811456680298, "1038": 0.35677260160446167, "1042": 1.1695996522903442, "1057": 0.5860490798950195, "1059": 0.9621002674102783, "2003": 0.2501201331615448, "2006": 0.5427330136299133, "2008": 0.10379679501056671, "2026": 0.5461324453353882, "2029": 0.2749055027961731, "2094": ... | 13277623 | FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. SCFFBW7 degrades several proto-oncogenes that function in cellular growth and division pathways, including MYC, cyclin E, Notch and JUN.... | FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation |
{"1003": 0.04487626627087593, "1015": 0.7210738658905029, "1016": 0.7009293437004089, "1043": 0.31489628553390503, "1044": 0.7370892763137817, "2001": 0.015504186972975731, "2004": 0.37707099318504333, "2007": 0.13157635927200317, "2012": 0.23402166366577148, "2028": 0.3262358605861664, "2043": 0.0842406153678894, "204... | 13282296 | CONTEXT Although acute hypoglycemia may be associated with cognitive impairment in children with type 1 diabetes, no studies to date have evaluated whether hypoglycemia is a risk factor for dementia in older patients with type 2 diabetes. OBJECTIVE To determine if hypoglycemic episodes severe enough to require hospital... | Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. |
{"1011": 0.08871890604496002, "1015": 0.4891071021556854, "1048": 0.07159364968538284, "1056": 0.5773153901100159, "1156": 0.39893341064453125, "2003": 0.09850110858678818, "2008": 0.055094651877880096, "2011": 0.010684899985790253, "2013": 0.07341018319129944, "2028": 0.2837681770324707, "2029": 0.2637155055999756, "2... | 13283919 | CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium release–activated calcium channels. A point mutation in the gene encoding CRACM1 is associated with severe combined immunodeficiency disease in humans. Here we generated CRACM1-deficient mice in which β-galactosidase activity 'reported' C... | Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels |
{"1011": 0.38308101892471313, "1021": 0.7482418417930603, "1049": 0.040196798741817474, "1997": 0.021256839856505394, "2003": 0.23556606471538544, "2004": 0.05139094591140747, "2008": 0.04860413447022438, "2012": 0.14349138736724854, "2015": 0.3622259199619293, "2024": 0.43812891840934753, "2029": 0.08782484382390976, ... | 13290521 | MicroRNAs (miRNAs) are a family of short, non-coding RNA molecules (∼22nt) involved in post-transcriptional control of gene expression. They act via base-pairing with mRNA transcripts that harbour target sequences, resulting in accelerated mRNA decay and/or translational attenuation. Given miRNAs mediate the expression... | MicroRNA-7: A miRNA with expanding roles in development and disease. |
{"1011": 0.06795065850019455, "1040": 0.4818955361843109, "1043": 0.3956514894962311, "1050": 0.040196798741817474, "1059": 0.8247235417366028, "2001": 0.040196798741817474, "2011": 0.12038381397724152, "2013": 0.1710275560617447, "2015": 0.5450005531311035, "2020": 0.1619328260421753, "2054": 0.13670019805431366, "205... | 13293033 | Down syndrome (DS) is the most frequent cause of human congenital mental retardation. Cognitive deficits in DS result from perturbations of normal cellular processes both during development and in adult tissues, but the mechanisms underlying DS etiology remain poorly understood. To assess the ability of induced pluripo... | Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology. |
{"1023": 0.567397952079773, "1054": 0.952351450920105, "1055": 0.6054253578186035, "2000": 0.06337817758321762, "2003": 0.0770333781838417, "2005": 0.3191637098789215, "2008": 0.06154331564903259, "2029": 0.255429208278656, "2064": 0.3177432417869568, "2079": 0.03360854089260101, "2094": 0.009718249551951885, "2099": 1... | 13296399 | Reliable genome editing via Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)/Cas9 may provide a means to correct inherited diseases in patients. As proof of principle, we show that CRISPR/Cas9 can be used in vivo to selectively ablate the rhodopsin gene carrying the dominant S334ter mutation (Rho(S334)... | In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa |
{"1014": 0.32341301441192627, "1040": 1.0151457786560059, "1048": 0.09672962874174118, "1051": 0.1485546976327896, "1052": 0.637939989566803, "1999": 0.007782140281051397, "2007": 0.19220098853111267, "2029": 0.10203468054533005, "2035": 0.0029254043474793434, "2044": 0.09050461649894714, "2058": 0.055094651877880096, ... | 13312471 | Vitamin D insufficiency is common, however within individuals, not all manifest the biochemical effects of PTH excess. This further extends to patients with established osteoporosis. The mechanism underlying the blunted PTH response is unclear but may be related to magnesium (Mg) deficiency. The aims of this study were... | Vitamin D insufficiency and the blunted PTH response in established osteoporosis: the role of magnesium deficiency |
{"1011": 0.0029254043474793434, "1043": 0.48068851232528687, "1046": 1.034073829650879, "1055": 0.1358480453491211, "1058": 0.1718502640724182, "2007": 0.1619328260421753, "2011": 0.083342544734478, "2015": 0.14095009863376617, "2029": 0.01934296265244484, "2042": 0.06612417846918106, "2047": 0.21530038118362427, "2060... | 13322804 | PURPOSE OF REVIEW The availability of a growing number of immunomodulatory medications over the past few years has been associated with various JC virus (JCV)-associated brain syndromes in patients with autoimmune diseases, including multiple sclerosis, Crohn's disease, and psoriasis that had not been previously recogn... | Novel syndromes associated with JC virus infection of neurons and meningeal cells: no longer a gray area. |
{"1011": 0.02792670577764511, "1017": 0.7191727757453918, "1042": 0.42735910415649414, "1044": 0.06520967930555344, "1047": 0.8748174905776978, "1052": 0.9546096324920654, "1053": 0.06154331564903259, "1054": 0.2667117714881897, "1170": 0.19220098853111267, "1996": 0.07884006202220917, "2011": 0.25694093108177185, "202... | 13329980 | AIMS AND BACKGROUND The PI3 kinase signalling pathway is now accepted as being at least as important as the ras-MAP kinase pathway in cell survival and proliferation, and hence its potential role in cancer is of great interest. The purpose of this review is briefly to examine evidence for an involvement of PI3K in huma... | Phosphoinositide 3-kinase signalling pathways in tumor progression, invasion and angiogenesis. |
{"1017": 0.12038381397724152, "1023": 0.1510767638683319, "1043": 0.1873544454574585, "1062": 0.36426326632499695, "1998": 0.4349733293056488, "1999": 0.34715715050697327, "2000": 0.1905880719423294, "2004": 0.08513788133859634, "2005": 0.3923587501049042, "2007": 0.0770333781838417, "2013": 0.17759032547473907, "2029"... | 13338820 | Objective: To assess the energy and nutrient adequacy of a variety of complementary foods used in parts of Africa, India, Papua New Guinea, the Philippines and Thailand. Method: The energy, nutrient and anti-nutrient (dietary fibre and phytic acid) content (per 100 g as eaten, per 100 kcal, and per day) of twenty-three... | Complementary foods for infant feeding in developing countries: their nutrient adequacy and improvement |
{"1015": 0.41647201776504517, "1038": 1.0992631912231445, "1999": 0.03360854089260101, "2028": 0.1710275560617447, "2029": 0.1619328260421753, "2031": 0.07341018319129944, "2033": 0.4400174915790558, "2038": 0.25239890813827515, "2066": 0.259204238653183, "2079": 0.012615402229130268, "2166": 0.5601736903190613, "2179"... | 13350374 | Mice deficient in the circadian transcription factor BMAL1 (brain and muscle ARNT-like protein) have impaired circadian behavior and demonstrate loss of rhythmicity in the expression of target genes. Here we report that Bmal1(-/-) mice have reduced lifespans and display various symptoms of premature aging including sar... | Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock. |
{"1006": 0.10026945173740387, "1009": 0.4356052577495575, "1011": 0.4891071021556854, "1015": 0.10555581003427505, "1018": 0.052318159490823746, "1038": 0.5191890001296997, "1039": 0.7463917136192322, "1041": 0.6989894509315491, "1043": 0.4574742913246155, "1044": 0.4400174915790558, "1048": 0.574020504951477, "1053": ... | 13368032 | To develop safer and more effective vectors for gene therapy of X-linked severe combined immunodeficiency (SCID-X1), we have evaluated new self-inactivating lentiviral vectors based on the HIV virus. The CL20i4-hgamma(c)-Revgen vector contains the entire human common gamma chain (gamma(c)) genomic sequence driven by th... | A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. |
{"1043": 0.7047978043556213, "1052": 0.36900100111961365, "1055": 0.6275664567947388, "2007": 0.1332872211933136, "2012": 0.14264501631259918, "2015": 0.25694093108177185, "2020": 0.10731173306703568, "2029": 0.21530038118362427, "2034": 0.2247048318386078, "2047": 0.21922965347766876, "2048": 0.0842406153678894, "2057... | 13373629 | BACKGROUND Recent genome-wide association studies (GWAS) have mapped several novel loci influencing blood lipid levels in Caucasians. We sought to explore whether the genetic variants at newly identified lipid-associated loci were associated with CHD susceptibility in a Chinese Han population. METHODOLOGY/PRINCIPAL FIN... | Genetic Variants at Newly Identified Lipid Loci Are Associated with Coronary Heart Disease in a Chinese Han Population |
{"1008": 0.5947071313858032, "1009": 0.4891071021556854, "1015": 0.1384023278951645, "1043": 0.5209306478500366, "1045": 0.7105726003646851, "1051": 0.7028654217720032, "1052": 0.47584590315818787, "2011": 0.3547199070453644, "2012": 0.5080875158309937, "2029": 0.16110190749168396, "2106": 0.09938567131757736, "2109": ... | 13380011 | Partial inhibition of mitochondrial respiratory complex I by rotenone reproduces aspects of Parkinson's disease in rodents. The hypothesis that rotenone enhancement of neuronal cell death is attributable to oxidative stress was tested in an acute glutamate excitotoxicity model using primary cultures of rat cerebellar g... | Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. |
{"1015": 0.15275461971759796, "1045": 1.1888195276260376, "2001": 0.10203468054533005, "2002": 1.0655186176300049, "2005": 0.4914994537830353, "2007": 0.16524957120418549, "2010": 0.09938567131757736, "2029": 0.056018441915512085, "2034": 0.45499902963638306, "2042": 0.007782140281051397, "2046": 0.06246116757392883, "... | 13380980 | Many treatments have been proposed for non-resectable primary or secondary hepatic cancer but the results have generally been disappointing. Isolated Hepatic Perfusion (IHP) was first attempted four decades ago but it gained acceptance only recently, after spectacular tumour responses were obtained by isolated limb per... | Isolated liver perfusion for non-resectable liver tumours: a review. |
{"1011": 0.3084607720375061, "1052": 0.12986256182193756, "1996": 0.24171993136405945, "2003": 0.33325836062431335, "2005": 0.06337817758321762, "2011": 0.24171993136405945, "2029": 0.02412080205976963, "2034": 0.24018502235412598, "2046": 0.29400965571403503, "2075": 0.9673105478286743, "2076": 0.347847044467926, "207... | 13384318 | Pre-mRNA splicing is a fundamental process required for the expression of most metazoan genes. It is carried out by the spliceosome, which catalyzes the removal of noncoding intronic sequences to assemble exons into mature mRNAs prior to export and translation. Given the complexity of higher eukaryotic genes and the re... | Combinatorial control of exon recognition. |
{"1009": 0.42799583077430725, "1011": 0.40806588530540466, "1018": 0.7925328612327576, "1039": 0.1332872211933136, "1048": 0.32905077934265137, "1056": 1.0298984050750732, "2007": 0.11430477350950241, "2008": 0.0752234235405922, "2011": 0.12642613053321838, "2029": 0.22548456490039825, "2035": 0.6170841455459595, "2044... | 13398997 | The CD28/cytotoxic T-lymphocyte antigen 4 (CTLA-4)blocker belatacept selectively inhibits alloreactive T cell responses but is associated with a high incidence of acute rejection following renal transplantation,which led us to investigate the etiology of belatacept–resistant graft rejection. T cells can differentiate i... | High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept. |
{"1011": 0.43244171142578125, "1038": 0.20022670924663544, "1043": 0.016465263441205025, "1046": 0.32341301441192627, "1155": 0.2786078155040741, "2003": 0.08513788133859634, "2005": 0.11604541540145874, "2008": 0.11691460013389587, "2010": 0.791648268699646, "2029": 0.12470348179340363, "2058": 0.2394166737794876, "20... | 13400643 | The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signalling pathways simultaneously. Here, using an innovative cell-based screen, we identify a structurally unique small molecule (named JIB-04) that specifically inhibits the ac... | A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth |
{"1011": 0.14686977863311768, "1039": 0.052318159490823746, "1043": 1.0158531665802002, "1045": 0.4938860833644867, "1155": 0.05786345899105072, "1996": 0.04207121208310127, "1999": 0.052318159490823746, "2011": 0.46302130818367004, "2029": 0.319873183965683, "2044": 0.06886265426874161, "2061": 0.27786844968795776, "2... | 13411519 | Following cell surface receptor activation, the alpha subunit of the Gq subclass of GTP-binding proteins activates the phosphoinositide signalling pathway. Here we examined the expression and localization of Gq protein alpha subunits in the adult mouse brain by in situ hybridization and immunohistochemistry. Of the fou... | Gq protein alpha subunits Galphaq and Galpha11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. |
{"1005": 0.09761575609445572, "1038": 1.1744394302368164, "1055": 0.574020504951477, "2001": 0.03925827145576477, "2002": 0.3416208028793335, "2005": 0.20739519596099854, "2008": 0.14518201351165771, "2013": 0.2470736801624298, "2029": 0.21687394380569458, "2061": 0.6674286723136902, "2079": 0.11081436276435852, "2109"... | 13439128 | The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A candidate for BLM was identified by direct selection of a cDNA derived from a 250 kb segment of the genome to which BLM had been assigned by somatic crossover point mapping. In this novel mapping met... | The Bloom's syndrome gene product is homologous to RecQ helicases |
{"1042": 0.41647201776504517, "1997": 0.2501201331615448, "1998": 0.1619328260421753, "2000": 0.28963330388069153, "2028": 0.036437395960092545, "2042": 0.1485546976327896, "2043": 0.12556517124176025, "2051": 0.04487626627087593, "2058": 0.1384023278951645, "2062": 0.04394211992621422, "2076": 0.12814582884311676, "20... | 13441037 | In this review, we address the natural history of obesity in children, the most promising family- and school-based approaches to the prevention of obesity, and the barriers and opportunities associated with secondary prevention. In childhood, the most important periods of risk appear to be the periods of adiposity rebo... | Preventing obesity in children and adolescents. |
{"1009": 0.3423145115375519, "1020": 0.18248429894447327, "1044": 0.5215105414390564, "1997": 0.17267228662967682, "1999": 0.036437395960092545, "2007": 0.17759032547473907, "2013": 0.1685553640127182, "2015": 0.5438674688339233, "2029": 0.056018441915512085, "2033": 0.7191727757453918, "2034": 0.026025565341114998, "2... | 13441537 | Abstract Culture of preimplantation mammalian embryos and cells can influence their subsequent growth and differentiation. Previously, we reported that culture of mouse embryonic stem cells is associated with deregulation of genomic imprinting and affects the potential for these cells to develop into normal fetuses. Th... | Culture of Preimplantation Mouse Embryos Affects Fetal Development and the Expression of Imprinted Genes1 |
{"1003": 0.22782009840011597, "1014": 0.11778303235769272, "1044": 0.3177432417869568, "1052": 0.18248429894447327, "1057": 0.02887592278420925, "1062": 0.47766464948654175, "1081": 0.8357921838760376, "2001": 0.12642613053321838, "2007": 0.4849066734313965, "2015": 1.0030416250228882, "2019": 0.6086184978485107, "2020... | 13445579 | BACKGROUND AND PURPOSE IAs are found in 2.3% of adults; the mean age at detection is 52 years. Prevalence is <0.5% in young adults. Early studies suggest that 10%-50% of patients with aortic coarctation have IAs. Screening recommendations are variable. We sought to examine the prevalence of IAs through screening with M... | Results of screening for intracranial aneurysms in patients with coarctation of the aorta. |
{"1015": 0.18167030811309814, "1016": 0.2160874605178833, "1039": 0.5347557663917542, "1041": 0.4794800877571106, "1043": 0.4500300884246826, "1044": 0.2918238639831543, "1045": 0.30486753582954407, "1052": 0.07431721687316895, "1156": 0.5232481360435486, "2007": 0.24171993136405945, "2025": 0.07068414986133575, "2026"... | 13448422 | This review discusses some of the mechanisms inherent in diabetes that predispose patients to increased cardiac morbidity and mortality. Single photon emission computerized tomography or photon emission tomography with radioactive labeled analogues of norepinephrine have shown that cardiac sympathetic dysfunction and i... | A new look at the heart in diabetes mellitus: from ailing to failing |
{"1015": 0.16690383851528168, "1017": 0.1485546976327896, "1020": 0.2689530849456787, "1039": 0.6970458030700684, "1042": 0.11517547070980072, "1056": 0.7942996621131897, "1062": 1.3033584356307983, "1997": 0.034552380442619324, "1999": 0.22392450273036957, "2005": 0.04860413447022438, "2008": 0.2089812457561493, "2011... | 13450938 | In the mouse, ZFP57 contains three classical Cys2His2 zinc finger domains (ZF) and recognizes the methylated TGC(met)CGC target sequence using the first and the second ZFs. In this study, we demonstrate that the human ZFP57 (hZFP57) containing six Cys2His2 ZFs, binds the same methylated sequence through the third and t... | Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1 |
{"1022": 0.1808556467294693, "1043": 0.8100618124008179, "1999": 0.07341018319129944, "2000": 0.04860413447022438, "2006": 0.016465263441205025, "2012": 0.011650617234408855, "2013": 0.15610189735889435, "2029": 0.04394211992621422, "2039": 0.15943801403045654, "2043": 0.04113444685935974, "2064": 0.3423145115375519, "... | 13458119 | Astrocytes can release glutamate in a calcium-dependent manner and consequently signal to adjacent neurons. Whether this glutamate release pathway is used during physiological signaling or is recruited only under pathophysiological conditions is not well defined. One reason for this lack of understanding is the limited... | Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons. |
{"1013": 0.018384648486971855, "1019": 0.2837681770324707, "1026": 0.083342544734478, "1044": 0.6613984704017639, "1050": 0.40220460295677185, "1052": 0.36086538434028625, "1998": 0.08961215615272522, "1999": 0.15943801403045654, "2002": 0.01934296265244484, "2007": 0.4132472574710846, "2044": 0.30989447236061096, "205... | 13464392 | OBJECTIVE Hypoproteinemia, fluid retention, and weight gain are associated with development of acute lung injury and mortality in critically ill patients, without proof of cause and effect. We designed a clinical trial to determine whether diuresis and colloid replacement in hypoproteinemic patients with acute lung inj... | Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. |
{"1042": 0.7380234599113464, "2003": 0.0058422754518687725, "2029": 0.030771657824516296, "2038": 0.04394211992621422, "2040": 0.015504186972975731, "2042": 0.0174254160374403, "2047": 0.27786844968795776, "2064": 0.15860503911972046, "2071": 0.2184450328350067, "2099": 0.083342544734478, "2109": 0.37371641397476196, "... | 13466517 | The techniques available for the interrogation and analysis of neuroimaging data have a large influence in determining the flexibility, sensitivity, and scope of neuroimaging experiments. The development of such methodologies has allowed investigators to address scientific questions that could not previously be answere... | Advances in functional and structural mr image analysis and implementation as fsl |
{"1043": 0.4067663550376892, "1049": 0.23710809648036957, "2002": 0.3499138653278351, "2003": 0.011650617234408855, "2005": 0.3084607720375061, "2011": 0.26296505331993103, "2033": 0.4481603503227234, "2042": 0.09672962874174118, "2064": 0.11951763927936554, "2078": 0.011650617234408855, "2079": 0.14602625370025635, "2... | 13466622 | Metformin has been the mainstay of therapy for diabetes mellitus for many years; however, the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed that this drug, in addition to its glucose-lowering action, might be promising for specifically targeting metabolic differences between nor... | Metformin—mode of action and clinical implications for diabetes and cancer |
{"1009": 0.5968599319458008, "1011": 0.27044451236724854, "1015": 0.6989894509315491, "1043": 0.3499138653278351, "1045": 0.15777134895324707, "1056": 0.4374985992908478, "2006": 0.05694137513637543, "2007": 0.401551216840744, "2011": 0.022212404757738113, "2015": 0.11604541540145874, "2025": 0.05139094591140747, "2028... | 13469921 | Recent cross-sectional analyses of HIV-1+ plasmas have indicated that broadly cross-reactive neutralizing antibody responses are developed by 10%-30% of HIV-1+ subjects. The timing of the initial development of such anti-viral responses is unknown. It is also unknown whether the emergence of these responses coincides w... | Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1 |
{"1014": 0.0038986403960734606, "1041": 0.26296505331993103, "1042": 0.2223619967699051, "1044": 0.75193190574646, "1048": 0.8143964409828186, "1053": 0.0029254043474793434, "1058": 0.10291612148284912, "2001": 0.011650617234408855, "2002": 0.1011524572968483, "2007": 0.18411032855510712, "2012": 0.21530038118362427, "... | 13481731 | OBJECTIVES This study was designed to determine if women are more likely than men to have heart failure (HF) with preserved systolic function after adjustment for potential confounders, including age. BACKGROUND Although prior evidence suggests an independent association between female gender and preserved left ventric... | Gender, age, and heart failure with preserved left ventricular systolic function. |
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