spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1040": 0.18167030811309814, "1059": 0.3923587501049042, "2005": 0.0019512200960889459, "2011": 0.10467668622732162, "2015": 0.6471850275993347, "2029": 0.07250232994556427, "2046": 0.2026219218969345, "2075": 0.2026219218969345, "2076": 0.5461324453353882, "2078": 0.42735910415649414, "2079": 0.011650617234408855, "2... | 13481880 | Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is currently unclear how this is orchestrated at the cellular level and how cell fate is affected by severe tissue damage. Here we dissect cell fate transitions during colonic regeneration in a mouse dextran sulfate sodium (DSS) colit... | YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration |
{"1011": 0.19862671196460724, "1043": 0.7845434546470642, "1998": 0.19782574474811554, "1999": 0.053244512528181076, "2005": 0.16442140936851501, "2006": 0.20660123229026794, "2007": 0.31204116344451904, "2011": 0.2954642176628113, "2029": 0.29036402702331543, "2039": 0.04953393340110779, "2057": 0.04674193635582924, "... | 13492264 | Glomerular basement membrane (GBM) and podocalyxin are essential for podocyte morphology. We provide evidence of functional interconnections between basement membrane components (collagen IV and laminin), the expression of podocalyxin and the morphology of human glomerular epithelial cells (podocytes). We demonstrated ... | Summary |
{"1012": 0.15777134895324707, "1013": 0.2516399025917053, "1049": 1.3118107318878174, "1054": 0.613389253616333, "2003": 0.469759464263916, "2015": 0.28155985474586487, "2033": 0.22704219818115234, "2054": 0.12556517124176025, "2079": 0.14686977863311768, "2088": 0.25845035910606384, "2109": 0.21765978634357452, "2140"... | 13494853 | The abbreviated name, 'mfold web server', describes a number of closely related software applications available on the World Wide Web (WWW) for the prediction of the secondary structure of single stranded nucleic acids. The objective of this web server is to provide easy access to RNA and DNA folding and hybridization ... | Mfold web server for nucleic acid folding and hybridization prediction |
{"1050": 0.32270604372024536, "2022": 0.08871890604496002, "2043": 0.23402166366577148, "2058": 0.020300358533859253, "2086": 0.5438674688339233, "2088": 0.045809537172317505, "2095": 0.1751343309879303, "2109": 0.07612881064414978, "2111": 0.20660123229026794, "2119": 0.24401791393756866, "2129": 0.056018441915512085,... | 13496853 | PURPOSE The aim of this study was to update reference data of handgrip strength for healthy adults of both genders spanning a wide age range and to analyze possible factors of influence. METHODS Intraindividual and interindividual variations of grip strength and their relation to several anthropometric factors were ana... | Grip strength in healthy caucasian adults: reference values. |
{"1003": 0.3241194784641266, "1020": 0.319873183965683, "1025": 0.17267228662967682, "1038": 0.3850763738155365, "1042": 0.8567397594451904, "1050": 0.5057345628738403, "1051": 0.7286425232887268, "1999": 0.06977381557226181, "2000": 0.2763880789279938, "2004": 0.176772341132164, "2007": 0.06703783571720123, "2029": 0.... | 13497630 | Importance Despite lack of evidence of their utility, biomarkers of ovarian reserve are being promoted as potential markers of reproductive potential. Objective To determine the associations between biomarkers of ovarian reserve and reproductive potential among women of late reproductive age. Design, Setting, and Parti... | Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age |
{"1011": 0.21765978634357452, "1013": 0.12986256182193756, "1038": 1.0409941673278809, "1039": 0.16690383851528168, "1041": 0.16359257698059082, "1043": 0.5865923762321472, "1051": 0.1970241367816925, "1156": 0.28890204429626465, "1996": 0.19220098853111267, "1998": 0.03266380727291107, "1999": 0.045809537172317505, "2... | 13509809 | The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the circulation. Here, we demonstrate that osteocytes, the major cellular component of mature bone, are regulators of HSPC egress. Granulocyte colony-stimulating factor (G... | Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. |
{"1011": 0.40611594915390015, "1044": 0.20022670924663544, "1051": 0.6793810129165649, "1998": 0.39762192964553833, "2002": 0.1685553640127182, "2005": 0.37907835841178894, "2008": 0.03831886500120163, "2011": 0.15275461971759796, "2013": 0.5341835021972656, "2022": 0.011650617234408855, "2029": 0.02412080205976963, "2... | 13513790 | Haploid cells are amenable for genetic analysis. Recent success in the derivation of mouse haploid embryonic stem cells (haESCs) via parthenogenesis has enabled genetic screening in mammalian cells. However, successful generation of live animals from these haESCs, which is needed to extend the genetic analysis to the o... | Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells |
{"1011": 0.0752234235405922, "1014": 0.5318912267684937, "1044": 0.10731173306703568, "1047": 0.6558387279510498, "1052": 0.5191890001296997, "2002": 1.0165601968765259, "2007": 0.007782140281051397, "2010": 0.015504186972975731, "2015": 0.6223390698432922, "2025": 0.18329764902591705, "2029": 0.0058422754518687725, "2... | 13514898 | INTRODUCTION Recent studies in septic patients showed that adverse effects of hydroxyethyl starches (HESs) possibly outweigh their benefits in severely impaired physiological haemostasis. It remains unclear whether this also applies to patient populations that are less vulnerable. In this meta-analysis, we evaluated th... | The impact of hydroxyethyl starches in cardiac surgery: a meta-analysis |
{"1003": 0.35745587944984436, "1023": 0.00875066313892603, "1997": 0.3897167444229126, "1998": 0.022212404757738113, "1999": 0.6684301495552063, "2001": 0.1946154683828354, "2005": 0.27044451236724854, "2012": 0.6096806526184082, "2020": 0.09584271162748337, "2022": 0.055094651877880096, "2037": 0.07341018319129944, "2... | 13515165 | BACKGROUND It is commonly written that more patients wish to die at home than currently achieve this. However, the evidence for preferences for place of terminal care and death has not been systematically reviewed. AIM To carry out a systematic literature review of the preferences for place of care and death among adva... | Place of care in advanced cancer: a qualitative systematic literature review of patient preferences. |
{"1014": 0.1970241367816925, "1016": 0.5696102976799011, "1020": 0.40285754203796387, "1039": 0.18004031479358673, "1047": 0.4950772523880005, "1055": 0.7067264318466187, "2015": 0.2231435477733612, "2029": 0.2018241584300995, "2048": 0.129004567861557, "2057": 0.10906458646059036, "2090": 0.055094651877880096, "2116":... | 13519661 | Background Checkpoint kinase 2 (CHEK2) averts cancer development by promoting cell cycle arrest and activating DNA repair in genetically damaged cells. Previous investigation has established a role for the CHEK2 gene in breast cancer aetiology, but studies have largely been limited to the rare 1100delC mutation. Whethe... | Linkage Disequilibrium Mapping of CHEK2: Common Variation and Breast Cancer Risk |
{"1011": 0.2089812457561493, "1043": 0.3526630103588104, "1996": 0.03925827145576477, "1997": 0.11343330889940262, "2006": 0.22626367211341858, "2007": 0.22782009840011597, "2011": 0.129004567861557, "2015": 0.07793712615966797, "2029": 0.17267228662967682, "2046": 0.28155985474586487, "2050": 0.33325836062431335, "206... | 13552682 | In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes. We present structures of the mammalian ribosome engaged with decoding factor⋅GTPase complexes representing intermediates of translation elongation (amino... | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes |
{"1011": 0.3883931338787079, "1016": 0.08692999184131622, "1018": 0.11778303235769272, "1039": 1.0795515775680542, "1043": 0.26146242022514343, "1056": 1.0298984050750732, "1999": 0.1011524572968483, "2002": 0.6573580503463745, "2029": 0.058784693479537964, "2044": 0.0317181795835495, "2046": 0.030771657824516296, "207... | 13573143 | Comparative Gene Identification-58 (CGI-58), a lipid droplet (LD)-associated protein, promotes intracellular triglyceride (TG) hydrolysis in vitro. Mutations in human CGI-58 cause TG accumulation in numerous tissues including intestine. Enterocytes are thought not to store TG-rich LDs, but a fatty meal does induce temp... | Intestinal Cgi-58 Deficiency Reduces Postprandial Lipid Absorption |
{"1011": 0.10818854719400406, "1016": 0.7352184057235718, "1043": 0.4831010699272156, "1056": 1.1894142627716064, "1999": 0.026025565341114998, "2003": 0.1602703034877777, "2004": 0.025073638185858727, "2008": 0.14518201351165771, "2011": 0.3339579105377197, "2029": 0.26820653676986694, "2048": 0.28597161173820496, "20... | 13578199 | Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matrix biology of many tissues and is implicated in the gluten-induced pathogenesis of celiac sprue. Although vertebrate transglutaminases have been studied extensively,... | Transglutaminase 2 Undergoes a Large Conformational Change upon Activation |
{"1048": 0.25088030099868774, "1049": 0.15943801403045654, "1057": 0.2976420819759369, "2001": 0.574020504951477, "2007": 0.04767346754670143, "2018": 0.22937409579753876, "2020": 0.20739519596099854, "2034": 0.3723714053630829, "2040": 0.014542185701429844, "2042": 0.2822965085506439, "2043": 0.5893046259880066, "2050... | 13580614 | To the Editor: From May 1995, when metformin was introduced in the United States, through June 30, 1996, the Food and Drug Administration (FDA) received reports of lactic acidosis in 66 patients treated with metformin. In 47 patients, the diagnosis was confirmed on the basis of circulating lactate values (>5 mmol per l... | Lactic acidosis in patients with diabetes treated with metformin. |
{"1011": 0.43875885009765625, "1015": 0.2674594223499298, "1017": 0.43244171142578125, "1023": 1.1530905961990356, "1052": 0.7482418417930603, "1996": 0.04953393340110779, "1997": 0.1221139207482338, "1999": 0.39893341064453125, "2004": 0.757441520690918, "2007": 0.3683255612850189, "2008": 0.09317722171545029, "2011":... | 13583521 | According to dogma, initiator caspases are activated through proximity-induced homodimerization, but some studies infer that during apoptosis caspase-9 may instead form a holoenzyme with the Apaf-1 apoptosome. Using several biochemical approaches, including a novel site-specific crosslinking technique, we provide the f... | The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities |
{"1011": 0.2830325961112976, "1015": 0.41001203656196594, "1038": 0.5104349255561829, "1045": 0.6332852244377136, "1996": 0.10379679501056671, "1997": 0.16442140936851501, "2008": 0.07250232994556427, "2011": 0.38441169261932373, "2012": 0.19220098853111267, "2015": 0.1619328260421753, "2019": 0.4734157919883728, "2028... | 13583615 | During meiosis I, kinetochores of sister chromatids are juxtaposed or fused and mono-orient, while homologous chromosomes that are paired by chiasmata (bivalents) have to biorient. In the absence of chiasmata, biorientation of sister chromatids (univalents), which carries a risk of aneuploidy, has been occasionally det... | Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I. |
{"1011": 0.12038381397724152, "1043": 0.4196864068508148, "2000": 0.14518201351165771, "2003": 0.03831886500120163, "2011": 0.2018241584300995, "2029": 0.18004031479358673, "2064": 0.14179791510105133, "2075": 0.020300358533859253, "2084": 0.27934664487838745, "2090": 0.3723714053630829, "2116": 0.01934296265244484, "2... | 13592721 | Synthetic gene expression is highly sensitive to intragenic compositional context (promoter structure, spacing regions between promoter and coding sequences, and ribosome binding sites). However, much less is known about the effects of intergenic compositional context (spatial arrangement and orientation of entire gene... | Biophysical Constraints Arising from Compositional Context in Synthetic Gene Networks. |
{"1043": 0.5318912267684937, "1054": 0.3325583338737488, "1055": 0.40871503949165344, "1997": 0.22782009840011597, "2005": 0.10993985831737518, "2006": 0.05139094591140747, "2011": 0.1693800985813141, "2029": 0.03360854089260101, "2054": 0.1064341589808464, "2064": 0.07068414986133575, "2076": 0.12038381397724152, "207... | 13613916 | Glucose is the primary source of energy for the budding yeast Saccharomyces cerevisiae. Although yeast cells can utilize a wide range of carbon sources, presence of glucose suppresses molecular activities involved in the use of alternate carbon sources as well as it represses respiration and gluconeogenesis. This domin... | Glucose repression in Saccharomyces cerevisiae |
{"1011": 0.319873183965683, "1015": 0.19541899859905243, "1016": 0.23092569410800934, "1037": 0.23633737862110138, "1039": 0.31132611632347107, "1040": 0.4624064862728119, "1041": 0.29473719000816345, "1043": 0.26820653676986694, "1047": 0.7047978043556213, "1052": 0.18329764902591705, "1055": 0.33953672647476196, "105... | 13614794 | The cyclin-dependent kinase Cdk2 associates with cyclins A, D, and E and has been implicated in the control of the G1 to S phase transition in mammals. To identify potential Cdk2 regulators, we have employed an improved two-hybrid system to isolate human genes encoding Cdk-interacting proteins (Cips). CIP1 encodes a no... | The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. |
{"1011": 0.3283478021621704, "1051": 0.8796916007995605, "1997": 0.034552380442619324, "2000": 0.040196798741817474, "2003": 0.15610189735889435, "2012": 0.3027053773403168, "2021": 0.10555581003427505, "2023": 0.02887592278420925, "2033": 0.319873183965683, "2034": 0.053244512528181076, "2051": 1.0008903741836548, "20... | 13618987 | Gene sequences sampled at different points in time can be used to infer molecular phylogenies on a natural timescale of months or years, provided that the sequences in question undergo measurable amounts of evolutionary change between sampling times. Data sets with this property are termed heterochronous and have becom... | Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen) |
{"1014": 0.25694093108177185, "1016": 0.6833335757255554, "1020": 0.17922431230545044, "1043": 0.8366385698318481, "1044": 0.2478361576795578, "1053": 0.7163142561912537, "2005": 0.04207121208310127, "2006": 0.11778303235769272, "2007": 0.29619070887565613, "2015": 0.07793712615966797, "2029": 0.053244512528181076, "20... | 13619127 | OBJECTIVE To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia in patients with type 2 diabetes associated with prescribed diabetes drugs, particularly newer agents including gliptins or glitazones (thiazolidinediones). DESIGN Open cohort study in primary care. SETTING ... | Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care |
{"1006": 0.3012613356113434, "1007": 0.03831886500120163, "1009": 0.7701805830001831, "1011": 0.23092569410800934, "1016": 0.4286321699619293, "1039": 0.19622190296649933, "1045": 0.4950772523880005, "1047": 1.0030416250228882, "1996": 0.007782140281051397, "1997": 0.1889725625514984, "1999": 0.18411032855510712, "2006... | 13621186 | In salamander rods, Ca(2+)-activated K(+) current (I(KCa)) provides an effective "clamp" of the dark membrane potential to its normal resting level. By a combination of electrophysiological, pharmacological, and immunohistochemical approaches, we show that salamander rods functionally express large-conductance Ca(2+)- ... | Vertebrate rod photoreceptors express both BK and IK calcium-activated potassium channels, but only BK channels are involved in receptor potential regulation. |
{"1014": 0.2637155055999756, "1018": 0.14179791510105133, "1052": 0.4145384132862091, "2005": 0.12642613053321838, "2006": 1.0802149772644043, "2011": 0.6054253578186035, "2028": 0.21372433006763458, "2034": 0.22548456490039825, "2044": 0.10467668622732162, "2051": 0.6254787445068359, "2053": 0.2918238639831543, "2075"... | 13624704 | The efficacy, safety and resource implications of a single intravenous dose of ondansetron (0.1 mg.kg-1, maximum 4 mg) were assessed in a multinational, multicentre, randomized, double-blind, placebo-controlled trial of 427 children aged 1-12 years, undergoing tonsillectomy with/without adenoidectomy. Emesis (retching ... | Ondansetron reduces nausea and vomiting after paediatric adenotonsillectomy. |
{"1039": 0.8161250352859497, "1043": 0.6400018334388733, "1053": 0.966567873954773, "2015": 0.11778303235769272, "2044": 0.18004031479358673, "2051": 0.11517547070980072, "2077": 0.2184450328350067, "2086": 0.5127768516540527, "2095": 0.07341018319129944, "2102": 0.0058422754518687725, "2109": 0.12470348179340363, "211... | 13625993 | OBJECTIVE To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery. DESIGN Decision analytical model comparing four prioritisation strategies without biomarkers... | Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery |
{"1009": 0.4531385898590088, "1011": 0.12986256182193756, "1021": 0.41195443272590637, "1022": 0.6482070088386536, "1039": 0.026025565341114998, "1056": 1.0775588750839233, "1157": 0.5936289429664612, "1996": 0.14179791510105133, "1999": 0.1685553640127182, "2008": 0.053244512528181076, "2012": 0.2394166737794876, "202... | 13636631 | Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor γ-chain (γc... | Cytokine control of memory T-cell development and survival |
{"1011": 0.06703783571720123, "1015": 0.03266380727291107, "1048": 0.6548244953155518, "2000": 0.05694137513637543, "2002": 0.04674193635582924, "2005": 0.18816383183002472, "2010": 0.9922385215759277, "2011": 0.2539152204990387, "2049": 0.1229778528213501, "2076": 0.01934296265244484, "2079": 0.20580662786960602, "210... | 13639330 | Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown. Here we report an unexpected and general strategy that i... | Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors |
{"1041": 0.09050461649894714, "1043": 0.48430517315864563, "1054": 0.0038986403960734606, "2003": 0.1221139207482338, "2005": 0.0174254160374403, "2011": 0.33953672647476196, "2026": 0.7782850861549377, "2029": 0.2145126610994339, "2058": 0.3269403576850891, "2063": 0.1332872211933136, "2076": 0.08782484382390976, "207... | 13651792 | IRGM, a human immunity-related GTPase, confers autophagic defence against intracellular pathogens by an unknown mechanism. Here, we report an unexpected mode of IRGM action. IRGM demonstrated differential affinity for the mitochondrial lipid cardiolipin, translocated to mitochondria, affected mitochondrial fission and ... | Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria |
{"1009": 0.24171993136405945, "1011": 0.3750596046447754, "1051": 0.44753631949424744, "1053": 0.04674193635582924, "1999": 0.016465263441205025, "2000": 0.05417001247406006, "2005": 0.21214580535888672, "2011": 0.05786345899105072, "2015": 0.25467249751091003, "2024": 0.15526613593101501, "2034": 0.2516399025917053, "... | 13702924 | Mosquitoes are vectors of a number of important human and animal diseases. The development of novel vector control strategies requires a thorough understanding of mosquito biology. To facilitate this, we used RNA-seq to identify novel genes and provide the first high-resolution view of the transcriptome throughout deve... | The Developmental Transcriptome of the Mosquito Aedes aegypti, an Invasive Species and Major Arbovirus Vector |
{"1003": 0.010684899985790253, "1014": 0.04860413447022438, "1039": 0.11430477350950241, "1052": 0.9739698171615601, "1059": 0.08244366943836212, "2007": 0.11081436276435852, "2011": 0.1229778528213501, "2044": 0.4093637466430664, "2075": 0.24171993136405945, "2089": 0.13071982562541962, "2090": 0.26446542143821716, "2... | 13714201 | Aims The gut microbiome influences metabolic syndrome (MetS) and inflammation and is therapeutically modifiable. Arterial stiffness is poorly correlated with most traditional risk factors. Our aim was to examine whether gut microbial composition is associated with arterial stiffness. Methods and results We assessed the... | Gut microbial diversity is associated with lower arterial stiffness in women |
{"1011": 0.2763880789279938, "1020": 0.23633737862110138, "1043": 0.21765978634357452, "1047": 0.4944818615913391, "1048": 0.16607704758644104, "1052": 0.7144040465354919, "1055": 0.03360854089260101, "1057": 0.2637155055999756, "1061": 0.3656192123889923, "2007": 0.06612417846918106, "2012": 0.029824240133166313, "201... | 13717103 | INTRODUCTION Mutations in the FUS gene have been shown to be a rare cause of amyotrophic lateral sclerosis (ALS-FUS) and whilst well documented clinically and genetically there have been relatively few neuropathological studies. Recent work suggested a possible correlation between pathological features such as frequenc... | ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation |
{"1044": 0.2026219218969345, "2013": 0.5255602598190308, "2015": 0.12470348179340363, "2025": 0.058784693479537964, "2031": 0.013579257763922215, "2038": 0.08603433519601822, "2039": 0.09672962874174118, "2042": 0.06429435312747955, "2072": 0.012615402229130268, "2073": 0.3141832649707794, "2088": 0.42990362644195557, ... | 13726379 | Coronary heart disease rates have been reported in several parts of the world to be unusually high in people originating from the Indian subcontinent. High coronary disease rates appear to be common to South Asian groups of different geographical origin, religion, and language. This presents a challenge to the understa... | Coronary heart disease in south Asians overseas: a review. |
{"1052": 0.20022670924663544, "1999": 0.4311734735965729, "2000": 0.2622140049934387, "2001": 0.05046287178993225, "2005": 0.21530038118362427, "2015": 0.011650617234408855, "2020": 0.11517547070980072, "2025": 0.259204238653183, "2043": 0.2852376699447632, "2052": 0.39762192964553833, "2053": 0.26146242022514343, "205... | 13732033 | OBJECTIVES To investigate the views of parents, clinicians, and children pertaining to prescribing decisions for acute childhood infection in primary care. METHODS A systematic review of qualitative studies. Meta-ethnographic methods were used, with data drawn from the primary studies in an interpretive analysis. RESUL... | A systematic review of parent and clinician views and perceptions that influence prescribing decisions in relation to acute childhood infections in primary care |
{"1003": 0.02887592278420925, "1052": 0.06703783571720123, "2001": 0.18573370575904846, "2007": 0.3897167444229126, "2012": 0.22859740257263184, "2013": 0.20580662786960602, "2019": 0.31489628553390503, "2020": 0.2394166737794876, "2043": 0.21293537318706512, "2044": 0.06612417846918106, "2090": 0.06154331564903259, "2... | 13734012 | OBJECTIVES To carry out a further survey of archived appendix samples to understand better the differences between existing estimates of the prevalence of subclinical infection with prions after the bovine spongiform encephalopathy epizootic and to see whether a broader birth cohort was affected, and to understand bett... | Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey |
{"1011": 0.2394166737794876, "1045": 0.11081436276435852, "1052": 0.6096806526184082, "1058": 0.3409265875816345, "1996": 0.06795065850019455, "1999": 0.5168620347976685, "2003": 0.016465263441205025, "2007": 0.2969166338443756, "2015": 0.25694093108177185, "2024": 0.1685553640127182, "2029": 0.15860503911972046, "2072... | 13757347 | GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV INs) are important regulators of cortical network excitability and of gamma oscillations, involved in signal processing and cognition. Impaired development or function of PV INs has been associated with epilepsy in various animal m... | Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy. |
{"1011": 0.2531573474407196, "1019": 0.08603433519601822, "1044": 0.7710843086242676, "2000": 0.08603433519601822, "2005": 0.04953393340110779, "2011": 0.1808556467294693, "2013": 0.11343330889940262, "2026": 0.8517522215843201, "2029": 0.30558720231056213, "2033": 0.0752234235405922, "2046": 0.40741631388664246, "2051... | 13759726 | The reconstruction of gene regulatory networks underlying cell differentiation from high-throughput gene expression and chromatin data remains a challenge. Here, we derive dynamic gene regulatory networks for human myeloid differentiation using a 5-day time series of RNA-seq and ATAC-seq data. We profile HL-60 promyelo... | Dynamic Gene Regulatory Networks of Human Myeloid Differentiation. |
{"1006": 0.10291612148284912, "1009": 0.6709295511245728, "1011": 0.15526613593101501, "1016": 0.5174443125724792, "1019": 0.0038986403960734606, "1997": 0.04674193635582924, "1999": 0.09317722171545029, "2004": 0.6149744987487793, "2005": 0.06337817758321762, "2007": 0.27934664487838745, "2011": 0.4734157919883728, "2... | 13760557 | Degranulation of mast cells in response to Ag or the calcium mobilizing agent, thapsigargin, is dependent on emptying of intracellular stores of Ca(2+) and the ensuing influx of external Ca(2+), also referred to as store-operated calcium entry. However, it is unlikely that the calcium release-activated calcium channel ... | Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line. |
{"1011": 0.27786844968795776, "1052": 0.7710843086242676, "1156": 0.0770333781838417, "2002": 0.7286425232887268, "2004": 0.055094651877880096, "2005": 0.3588210940361023, "2007": 0.2607102394104004, "2008": 0.08603433519601822, "2011": 0.1718502640724182, "2015": 0.3381449282169342, "2024": 0.20580662786960602, "2029"... | 13763195 | Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, leading to lower... | LincRNA-p21 suppresses target mRNA translation. |
{"1039": 0.6363908052444458, "1045": 0.8272887468338013, "1054": 0.9348671436309814, "1058": 0.1212492436170578, "1996": 0.06612417846918106, "1998": 0.11430477350950241, "2000": 0.2516399025917053, "2005": 0.3177432417869568, "2011": 0.2478361576795578, "2021": 0.04674193635582924, "2029": 0.20739519596099854, "2048":... | 13764090 | Both rectal and vaginal mucosal surfaces serve as transmission routes for pathogenic microorganisms. Vaccination through large intestinal mucosa, previously proven protective for both of these mucosal sites in animal studies, can be achieved successfully by direct intracolorectal (i.c.r.) administration, but this route... | Large intestine-targeted nanoparticle-releasing oral vaccine to control genitorectal viral infection |
{"1014": 0.36290550231933594, "1018": 0.05694137513637543, "1019": 0.09672962874174118, "1022": 0.11865071207284927, "1998": 0.1064341589808464, "2012": 0.4337083101272583, "2034": 0.9108069539070129, "2043": 0.08244366943836212, "2044": 0.06520967930555344, "2051": 0.20580662786960602, "2062": 0.3106105625629425, "207... | 13765757 | Ages at menarche and first birth are established risk factors for breast cancer. The interval between these ages may also affect risk, since the breast is more susceptible to carcinogenic insults during this period than during the parous period. However, few investigators have studied this relation. Using logistic regr... | Timing of menarche and first full-term birth in relation to breast cancer risk. |
{"1011": 0.23710809648036957, "1013": 0.14602625370025635, "1014": 0.31489628553390503, "1017": 0.21687394380569458, "1018": 0.05046287178993225, "1026": 0.014542185701429844, "1041": 0.2493593990802765, "1048": 0.9568626880645752, "1050": 0.06337817758321762, "1052": 0.1873544454574585, "1056": 0.4950772523880005, "20... | 13768432 | BACKGROUND The prognosis and treatment of the 2 main types of cardiac amyloidosis, immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis, are substantially influenced by cardiac involvement. Cardiovascular magnetic resonance with late gadolinium enhancement (LGE) is a reference standard for the diagnosis... | Prognostic Value of Late Gadolinium Enhancement Cardiovascular Magnetic Resonance in Cardiac Amyloidosis |
{"1003": 0.0842406153678894, "1017": 0.38574060797691345, "1020": 0.129004567861557, "1022": 0.2470736801624298, "1023": 0.043007105588912964, "1038": 0.42735910415649414, "1043": 0.4855078160762787, "1997": 0.4855078160762787, "1998": 0.23479416966438293, "2001": 0.09228714555501938, "2011": 0.07250232994556427, "2012... | 13770184 | BACKGROUND The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance ... | Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 |
{"1011": 0.06977381557226181, "1019": 0.18816383183002472, "1038": 0.5893046259880066, "1044": 0.2976420819759369, "1053": 0.5957841277122498, "1054": 0.6389714479446411, "2002": 1.0512858629226685, "2003": 0.24325250089168549, "2013": 0.1485546976327896, "2014": 0.41840189695358276, "2024": 0.3784096837043762, "2029":... | 13771184 | RecQ helicases are an important family of genome surveillance proteins conserved from bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome maintenance and stability, and the RecQ protein family members are often referred to as guardians of the genome. The importance of these proteins... | Human RecQ helicases in DNA repair, recombination, and replication. |
{"1011": 0.12986256182193756, "1039": 0.5232481360435486, "1044": 0.25845035910606384, "1053": 0.35950297117233276, "1055": 0.24631060659885406, "1056": 0.45623743534088135, "1999": 0.13670019805431366, "2000": 0.6902132034301758, "2002": 0.42990362644195557, "2005": 0.5646255612373352, "2006": 0.06977381557226181, "20... | 13774178 | BACKGROUND Schisandra, a globally distributed plant, has been widely applied for the treatment of diseases such as hyperlipidemia, fatty liver and obesity in China. In the present work, a rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (RRLC-Q-TOF-MS)-based metabolomics wa... | Metabolomics study of the therapeutic mechanism of Schisandra Chinensis lignans in diet-induced hyperlipidemia mice |
{"1011": 0.2983669638633728, "1015": 0.2034190446138382, "1019": 0.9092346429824829, "1042": 0.08244366943836212, "1056": 0.1221139207482338, "1999": 0.02887592278420925, "2002": 0.28890204429626465, "2007": 0.12814582884311676, "2008": 0.13925230503082275, "2011": 0.319873183965683, "2028": 0.007782140281051397, "2029... | 13777138 | TET family enzymes convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. Here, we show that Tet1 and Tet2 are Oct4-regulated enzymes that together sustain 5hmC in mouse embryonic stem cells (ESCs) and are induced concomitantly with 5hmC during reprogramming of fibroblasts to induced pluripotent stem ... | Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. |
{"1009": 0.32270604372024536, "1011": 0.2983669638633728, "1019": 0.18573370575904846, "1021": 0.6075552701950073, "1052": 0.38308101892471313, "1055": 0.5110208988189697, "2003": 0.06337817758321762, "2008": 0.045809537172317505, "2011": 0.3019835948944092, "2015": 0.7800771594047546, "2024": 0.306306391954422, "2029"... | 13777706 | Polycomb repressor complexes (PRCs) are important chromatin modifiers fundamentally implicated in pluripotency and cancer. Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and primed RNA polymerase II (RNAPII), but the relationship between PRCs and RNAPII remains unclear genome-w... | Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs |
{"1011": 0.1930064558982849, "1015": 0.5551415085792542, "1021": 0.15860503911972046, "1039": 0.5517725944519043, "1040": 0.08154398202896118, "1041": 0.1221139207482338, "1043": 0.18573370575904846, "1047": 0.42608439922332764, "2007": 0.11430477350950241, "2008": 0.10467668622732162, "2028": 0.14686977863311768, "202... | 13778710 | Chemokine-like receptor 1 (CMKLR1), also known as ChemR23, and chemokine (C-C motif) receptor-like 2 (CCRL2) are 7-transmembrane receptors that were cloned in the late 1990s based on their homology to known G-protein-coupled receptors. They were previously orphan receptors without any known biological roles; however, r... | Chemokine-like receptor 1 (CMKLR1) and chemokine (C-C motif) receptor-like 2 (CCRL2); two multifunctional receptors with unusual properties. |
{"1017": 0.2539152204990387, "1039": 0.7182208299636841, "1058": 0.5914691090583801, "2003": 0.015504186972975731, "2011": 0.4818955361843109, "2013": 0.28963330388069153, "2024": 0.14179791510105133, "2029": 0.05046287178993225, "2045": 0.1358480453491211, "2076": 0.07793712615966797, "2078": 0.07341018319129944, "207... | 13779605 | There is mounting evidence that tumors are initiated by a rare subset of cells called cancer stem cells (CSCs). CSCs are generally quiescent, self-renew, form tumors at low numbers, and give rise to the heterogeneous cell types found within a tumor. CSCs isolated from multiple tumor types differentiate both in vivo and... | Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation. |
{"1015": 0.42926809191703796, "1018": 0.020300358533859253, "1051": 0.2539152204990387, "2003": 0.036437395960092545, "2011": 0.36086538434028625, "2015": 0.21372433006763458, "2025": 0.1229778528213501, "2028": 0.20818853378295898, "2043": 0.18167030811309814, "2046": 0.32129061222076416, "2061": 0.1510767638683319, "... | 13780287 | When cells are activated by calcium-mobilizing agonists at low, physiological concentrations, the resulting calcium signals generally take the form of repetitive regenerative discharges of stored calcium, termed calcium oscillations [1]. These intracellular calcium oscillations have long fascinated biologists as a mode... | STIM1 Is a Calcium Sensor Specialized for Digital Signaling |
{"1003": 0.17840765416622162, "1014": 0.37640097737312317, "1017": 0.3409265875816345, "1057": 0.565735399723053, "2005": 0.012615402229130268, "2011": 0.0752234235405922, "2043": 0.1734936386346817, "2051": 0.42225050926208496, "2058": 0.14179791510105133, "2087": 0.3560888469219208, "2093": 0.5816917419433594, "2095"... | 13782317 | OBJECTIVE This report presents national estimates of the use of complementary health approaches among adults in the United States across three time points. Trends in the use of selected complementary health approaches are compared for 2002, 2007, and 2012, and differences by selected demographic characteristics are als... | Trends in the use of complementary health approaches among adults: United States, 2002-2012. |
{"1011": 0.18816383183002472, "1044": 0.38374659419059753, "1996": 0.07068414986133575, "1997": 0.21214580535888672, "1999": 0.09495500475168228, "2002": 0.45499902963638306, "2007": 0.05694137513637543, "2010": 1.4161186218261719, "2014": 0.04953393340110779, "2029": 0.14349138736724854, "2032": 0.03360854089260101, "... | 13790144 | Histone proteins play essential structural and functional roles in the transition between active and inactive chromatin states. Although histones have a high degree of conservation due to constraints to maintain the overall structure of the nucleosomal octameric core, variants have evolved to assume diverse roles in ge... | Histone structure and nucleosome stability. |
{"1003": 0.03925827145576477, "1014": 0.27044451236724854, "1018": 0.006812678650021553, "1023": 0.0606246218085289, "1039": 0.13670019805431366, "1997": 0.18654440343379974, "2001": 0.06886265426874161, "2012": 0.20580662786960602, "2018": 0.13414156436920166, "2019": 0.40481385588645935, "2034": 0.05694137513637543, ... | 13791044 | CONTEXT Although preterm delivery is a well-established risk factor for cerebral palsy (CP), preterm deliveries contribute only a minority of affected infants. There is little information on the relation of CP risk to gestational age in the term range, where most CP occurs. OBJECTIVE To determine whether timing of birt... | Cerebral palsy among term and postterm births. |
{"1015": 0.27342069149017334, "1018": 0.1384023278951645, "2011": 0.4177590310573578, "2025": 0.10467668622732162, "2033": 0.07159364968538284, "2046": 0.2622140049934387, "2064": 0.2447827309370041, "2075": 0.06154331564903259, "2076": 0.5495203733444214, "2079": 0.09672962874174118, "2090": 0.27786844968795776, "2094... | 13791206 | Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chromosome rearrangements by a process dependent on the nonhomologous end-joining... | 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks |
{"1998": 0.05786345899105072, "2004": 0.0058422754518687725, "2013": 0.5427330136299133, "2015": 0.3963087201118469, "2020": 0.1930064558982849, "2033": 0.7942996621131897, "2038": 0.02412080205976963, "2045": 0.0029254043474793434, "2060": 0.25239890813827515, "2070": 0.27786844968795776, "2073": 0.14095009863376617, ... | 13791788 | Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratificatio... | The genetics of Mexico recapitulates Native American substructure and affects biomedical traits |
{"1045": 0.3106105625629425, "1047": 0.6312094330787659, "1999": 0.034552380442619324, "2003": 0.21687394380569458, "2005": 0.10906458646059036, "2011": 0.24018502235412598, "2012": 0.5376120805740356, "2024": 0.40351006388664246, "2029": 0.014542185701429844, "2048": 0.10993985831737518, "2054": 0.036437395960092545, ... | 13794374 | Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin, adipocyte differentiation related protein, tail interacting prot... | COPI Complex Is a Regulator of Lipid Homeostasis |
{"1018": 0.6714286804199219, "1039": 0.46853771805763245, "1056": 1.0815403461456299, "1999": 0.04487626627087593, "2005": 0.09495500475168228, "2009": 0.6583697199821472, "2024": 0.020300358533859253, "2029": 0.15943801403045654, "2043": 0.04487626627087593, "2046": 0.15275461971759796, "2076": 0.5098485946655273, "20... | 13798951 | CD4 T cells play critical roles in mediating adaptive immunity to a variety of pathogens. They are also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity. During TCR activation in a particular cytokine milieu, naive CD4 T cells may differentiate into one of several lineages of T help... | Differentiation of effector CD4 T cell populations (*). |
{"1011": 0.08603433519601822, "1014": 0.23864774405956268, "1044": 0.1994270235300064, "1048": 0.1619328260421753, "1997": 0.08154398202896118, "1999": 0.25845035910606384, "2000": 0.19782574474811554, "2002": 0.6838265657424927, "2007": 0.13499516248703003, "2013": 0.036437395960092545, "2022": 0.08603433519601822, "2... | 13801259 | We have developed a modified version of our fully automated column-switching HPLC method for determining total plasma homocysteine based on single-column (reversed-phase) separation. Homocysteine, cysteine, and cysteinylglycine in plasma (total concentrations), acid-precipitated plasma (non-protein-bound concentrations... | Homocysteine and other thiols in plasma and urine: automated determination and sample stability. |
{"1011": 0.1619328260421753, "1055": 0.05139094591140747, "2000": 0.026976587250828743, "2015": 0.5936289429664612, "2054": 0.04674193635582924, "2064": 0.05139094591140747, "2087": 0.2830325961112976, "2109": 0.3963087201118469, "2111": 0.14686977863311768, "2114": 0.4248080551624298, "2214": 0.5450005531311035, "2216... | 13814480 | Alzheimer's disease (AD) is the most common cause of dementia in those over the age of 65. While a numerous of disease-causing genes and risk factors have been identified, the exact etiological mechanisms of AD are not yet completely understood, due to the inability to test theoretical hypotheses on non-postmortem and ... | Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy |
{"1011": 0.14095009863376617, "1016": 0.21922965347766876, "1045": 0.03925827145576477, "1050": 0.520350456237793, "1060": 0.09050461649894714, "1999": 0.18978065252304077, "2000": 0.09317722171545029, "2003": 0.020300358533859253, "2004": 0.06154331564903259, "2011": 0.3077431619167328, "2012": 0.24401791393756866, "2... | 13823200 | Nitrite (NO(2)(-)), previously viewed as a physiologically inert metabolite and biomarker of the endogenous vasodilator NO, was recently identified as an important biological NO reservoir in vasculature and tissues, where it contributes to hypoxic signaling, vasodilation, and cytoprotection after ischemia-reperfusion i... | Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase–dependent manner |
{"1014": 0.25845035910606384, "1022": 0.42735910415649414, "1023": 0.018384648486971855, "1997": 0.0038986403960734606, "2003": 0.025073638185858727, "2011": 0.22704219818115234, "2043": 0.15610189735889435, "2044": 0.6212902665138245, "2051": 0.5404602885246277, "2058": 0.3588210940361023, "2062": 0.2184450328350067, ... | 13831558 | BACKGROUND Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection of cancer by mammography difficult, but the influence of density on risk according to method of cancer detection is unknown. METHODS We carried out three nested case-control studies in screened popula... | Mammographic density and the risk and detection of breast cancer. |
{"1013": 0.026976587250828743, "1014": 0.28963330388069153, "1019": 0.4487839937210083, "1023": 0.021256839856505394, "1038": 0.757441520690918, "2044": 0.151916041970253, "2090": 0.49923527240753174, "2111": 0.013579257763922215, "2116": 0.32553088665008545, "2152": 0.08603433519601822, "2177": 0.08692999184131622, "2... | 13831842 | The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other ris... | Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. |
{"1039": 0.3070250153541565, "1044": 0.06886265426874161, "1050": 0.2561853528022766, "1051": 0.41195443272590637, "1052": 0.41647201776504517, "1069": 0.1889725625514984, "2053": 0.4537591338157654, "2072": 0.0058422754518687725, "2080": 0.1401015669107437, "2094": 0.5197699069976807, "2095": 0.3499138653278351, "2109... | 13843341 | OBJECTIVE To evaluate the cost effectiveness of standard treatment with and without the addition of ward based non-invasive ventilation in patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease. DESIGN Incremental cost effectiveness analysis of a randomised controlled trial. S... | Cost effectiveness of ward based non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease: economic analysis of randomised controlled trial. |
{"1009": 0.7500885725021362, "1011": 0.20421554148197174, "1013": 0.030771657824516296, "1014": 0.2394166737794876, "1017": 0.3353555500507355, "1019": 0.1358480453491211, "1039": 0.23556606471538544, "1044": 0.129004567861557, "1052": 0.03831886500120163, "1058": 0.1685553640127182, "2001": 0.3423145115375519, "2003":... | 13857083 | Detection of persistent cervical carcinogenic human papillomavirus (HPV) DNA is used as a marker for cervical cancer risk in clinical trials. The authors performed a systematic review and meta-analysis of the association between persistent HPV DNA and high-grade cervical intraepithelial neoplasia (CIN2-3), high-grade s... | Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis. |
{"1011": 0.030771657824516296, "1057": 0.29109421372413635, "1059": 1.2802826166152954, "1061": 0.7610978484153748, "1156": 0.39893341064453125, "1996": 0.07431721687316895, "2011": 0.22001366317272186, "2029": 0.11517547070980072, "2044": 0.009718249551951885, "2061": 0.6128603219985962, "2066": 0.07159364968538284, "... | 13867350 | The canonical Wnt signaling pathway is of paramount importance in development and disease. An emergent question is whether the upstream cascade of the canonical Wnt pathway has physiologically relevant roles beyond β-catenin-mediated transcription, which is difficult to study due to the pervasive role of this protein. ... | Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation |
{"1011": 0.2105647772550583, "1039": 0.3910386264324188, "1056": 0.997294545173645, "2005": 0.07341018319129944, "2006": 0.16442140936851501, "2008": 0.02792670577764511, "2011": 0.1994270235300064, "2029": 0.151916041970253, "2046": 0.1477125883102417, "2075": 0.11430477350950241, "2079": 0.10818854719400406, "2090": ... | 13868795 | Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure, and biochemistry of CD28 and its ligands. CD28 signals play a key role in many T cell processes, including cytoskeletal remodeling,... | CD28 Costimulation: From Mechanism to Therapy. |
{"1041": 0.19381128251552582, "1045": 0.42225050926208496, "1048": 0.04674193635582924, "1049": 0.4974553883075714, "1054": 0.16442140936851501, "2003": 0.04207121208310127, "2005": 0.3084607720375061, "2006": 0.24325250089168549, "2007": 0.09850110858678818, "2009": 0.14179791510105133, "2012": 0.1930064558982849, "20... | 13870943 | The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised crit... | Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. |
{"1011": 0.05970508232712746, "1018": 0.09495500475168228, "1038": 0.24859806895256042, "1043": 0.9515975713729858, "1054": 1.185243844985962, "1996": 0.2637155055999756, "1999": 0.056018441915512085, "2005": 0.014542185701429844, "2008": 0.025073638185858727, "2011": 0.1970241367816925, "2012": 0.10906458646059036, "2... | 13878124 | Radial glial cells (RGCs) in the developing cerebral cortex are progenitors for neurons and glia, and their processes serve as guideposts for migrating neurons. So far, it has remained unclear whether RGC processes also control the function of RGCs more directly. Here, we show that RGC numbers and cortical size are red... | Regulation of radial glial survival by signals from the meninges. |
{"1007": 0.022212404757738113, "1009": 0.8349450826644897, "1011": 0.15943801403045654, "1022": 0.6202403903007507, "1039": 0.175953671336174, "1056": 0.8941729068756104, "2005": 0.12986256182193756, "2012": 0.1384023278951645, "2020": 0.07431721687316895, "2029": 0.10818854719400406, "2033": 0.2969166338443756, "2037"... | 13878643 | Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition ... | The sterol regulatory element binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity |
{"2001": 0.5139457583427429, "2009": 0.259204238653183, "2011": 0.31560876965522766, "2013": 0.007782140281051397, "2018": 0.11778303235769272, "2020": 0.23402166366577148, "2038": 0.16276304423809052, "2042": 0.20739519596099854, "2043": 0.4487839937210083, "2052": 0.14349138736724854, "2058": 0.21765978634357452, "20... | 13882658 | The summer of 2003 was probably the hottest in Europe since at latest ad 1500, and unusually large numbers of heat-related deaths were reported in France, Germany and Italy. It is an ill-posed question whether the 2003 heatwave was caused, in a simple deterministic sense, by a modification of the external influences on... | Human contribution to the European heatwave of 2003 |
{"1037": 0.030771657824516296, "2003": 0.31489628553390503, "2024": 0.10467668622732162, "2046": 0.14939609169960022, "2052": 0.11865071207284927, "2054": 0.5261374711990356, "2064": 0.05694137513637543, "2070": 0.11517547070980072, "2071": 0.20739519596099854, "2079": 0.40546512603759766, "2089": 0.3615458607673645, "... | 13883546 | The term antidepressant refers to a drug that helps to rectify specific biological abnormalities that give rise to the symptoms of depression. This exemplifies what we have called the “disease-centred” model of psychotropic drug action [ 1]. Modelled on paradigmatic situations in general medicine—such as the use of ins... | Do Antidepressants Cure or Create Abnormal Brain States? |
{"1011": 0.1710275560617447, "1041": 0.272677481174469, "1042": 0.7445381283760071, "1043": 0.011650617234408855, "1056": 0.9052929878234863, "1155": 0.5278670787811279, "1156": 0.6553317308425903, "1996": 0.03925827145576477, "2007": 0.03831886500120163, "2011": 0.45870962738990784, "2012": 0.2969166338443756, "2026":... | 13889430 | There is a growing interest in the cell-cell communication roles in cancer mediated by secreted vesicles termed exosomes. In this study, we examined whether exosomes produced by cancer cells could transmit information to normal stromal fibroblasts and trigger a cellular response. We found that some cancer-derived exoso... | Cancer exosomes trigger fibroblast to myofibroblast differentiation. |
{"1011": 0.06886265426874161, "1019": 0.8925741910934448, "1039": 0.5255602598190308, "1045": 0.49864232540130615, "1049": 0.4151833653450012, "1056": 0.3034266233444214, "1060": 0.5968599319458008, "1999": 0.1808556467294693, "2003": 0.22157983481884003, "2020": 0.018384648486971855, "2026": 1.0641717910766602, "2033"... | 13889962 | The 5T33 multiple myeloma is one of a series of transplantable murine myelomas arising spontaneously in C57BL/KaLwRij mice. This study describes the establishment and characterisation of the 5T33 murine myeloma in vitro as a cultured cell line in terms of its morphology, growth rate, expression of paraprotein (IgG2b) a... | A model of multiple myeloma: culture of 5T33 murine myeloma cells and evaluation of tumorigenicity in the C57BL/KaLwRij mouse. |
{"1003": 0.17267228662967682, "1018": 0.02316705882549286, "1021": 0.20421554148197174, "1022": 0.22704219818115234, "1061": 0.7510106563568115, "1085": 0.44753631949424744, "1997": 0.21765978634357452, "2039": 0.07884006202220917, "2042": 0.04113444685935974, "2044": 0.3241194784641266, "2045": 0.11691460013389587, "2... | 13899137 | BACKGROUND Many mathematical models have investigated the impact of expanding access to antiretroviral therapy (ART) on new HIV infections. Comparing results and conclusions across models is challenging because models have addressed slightly different questions and have reported different outcome metrics. This study co... | HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa |
{"1003": 0.025073638185858727, "1998": 0.42735910415649414, "1999": 0.09761575609445572, "2001": 0.15275461971759796, "2004": 0.06429435312747955, "2011": 0.11517547070980072, "2012": 0.2976420819759369, "2015": 0.00875066313892603, "2020": 0.24401791393756866, "2037": 0.0842406153678894, "2042": 0.09850110858678818, "... | 13900610 | BACKGROUND Self-harm and suicide are common in prisoners, yet robust information on the full extent and characteristics of people at risk of self-harm is scant. Furthermore, understanding how frequently self-harm is followed by suicide, and in which prisoners this progression is most likely to happen, is important. We ... | Self-harm in prisons in England and Wales: an epidemiological study of prevalence, risk factors, clustering, and subsequent suicide |
{"1014": 0.40089741349220276, "1021": 0.2607102394104004, "1056": 0.11343330889940262, "1057": 0.15943801403045654, "1061": 0.38574060797691345, "1085": 0.026976587250828743, "1998": 0.4487839937210083, "2000": 0.1384023278951645, "2001": 0.07612881064414978, "2003": 0.13414156436920166, "2012": 0.05417001247406006, "2... | 13901073 | BACKGROUND Expanded access to antiretroviral therapy (ART) using universal test and treat (UTT) has been suggested as a strategy to eliminate HIV in South Africa within 7 y based on an influential mathematical modeling study. However, the underlying deterministic model was criticized widely, and other modeling studies ... | Elimination of HIV in South Africa through Expanded Access to Antiretroviral Therapy: A Model Comparison Study |
{"1009": 0.22157983481884003, "1011": 0.1011524572968483, "1019": 0.5712664127349854, "1043": 0.6613984704017639, "1056": 1.0080435276031494, "1155": 0.42353010177612305, "1164": 0.2478361576795578, "2003": 0.006812678650021553, "2011": 0.23015019297599792, "2029": 0.23864774405956268, "2033": 0.4891071021556854, "2050... | 13902570 | OBJECTIVE TGR5 is a G-protein-coupled receptor for bile acids. So far, little is known about the function of TGR5 in vascular endothelial cells. APPROACH AND RESULTS In bovine aortic endothelial cells, treatment with a bile acid having a high affinity to TGR5, taurolithocholic acid (TLCA), significantly increased NO pr... | Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. |
{"1011": 0.10203468054533005, "1042": 0.6260011196136475, "1052": 0.5795059204101562, "1998": 0.0317181795835495, "2003": 0.08154398202896118, "2007": 0.13670019805431366, "2024": 0.1485546976327896, "2029": 0.07612881064414978, "2072": 0.14349138736724854, "2075": 0.176772341132164, "2155": 1.0748957395553589, "2159":... | 13903052 | The Caliciviridae family comprises positive-sense RNA viruses of medical and veterinary significance. In humans, caliciviruses are a major cause of acute gastroenteritis, while in animals respiratory illness, conjunctivitis, stomatitis, and hemorrhagic disease are documented. Investigation of virus-host interactions is... | Structural insights into calicivirus attachment and uncoating. |
{"1011": 0.18492233753204346, "1017": 0.4041621685028076, "1028": 0.2689530849456787, "1042": 0.06977381557226181, "1043": 0.5472630262374878, "1054": 0.37707099318504333, "1056": 0.6000806093215942, "1997": 0.12814582884311676, "2025": 0.0029254043474793434, "2029": 0.19782574474811554, "2035": 0.32553088665008545, "2... | 13905670 | The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into... | Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway |
{"1011": 0.037378571927547455, "1014": 0.37907835841178894, "1998": 0.13499516248703003, "2012": 0.058784693479537964, "2021": 0.06429435312747955, "2049": 0.19541899859905243, "2053": 0.2160874605178833, "2060": 0.4462870955467224, "2062": 0.06246116757392883, "2066": 0.12728634476661682, "2082": 0.016465263441205025,... | 13906581 | Background Extensive debate exists in the healthcare community over whether outcomes of medical care at teaching hospitals and other healthcare units are better or worse than those at the respective nonteaching ones. Thus, our goal was to systematically evaluate the evidence pertaining to this question. Methods and Fi... | Patient Outcomes with Teaching Versus Nonteaching Healthcare: A Systematic Review |
{"1011": 0.07612881064414978, "1019": 0.17759032547473907, "1044": 0.5612884759902954, "1998": 0.14433705806732178, "1999": 0.009718249551951885, "2002": 0.01934296265244484, "2010": 0.75193190574646, "2011": 0.3824150264263153, "2029": 0.1358480453491211, "2043": 0.2689530849456787, "2044": 0.679875910282135, "2051": ... | 13906892 | We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation pattern of the repaired segment. HR also alters local histone H3 methylation as well chromatin structure by inducing DNA-chromatin loops connect... | DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism |
{"1011": 0.4537591338157654, "1044": 0.13755162060260773, "1052": 0.2637155055999756, "1997": 0.12038381397724152, "1999": 0.151916041970253, "2004": 0.14349138736724854, "2005": 0.0317181795835495, "2008": 0.037378571927547455, "2010": 0.9371650815010071, "2011": 0.3963087201118469, "2012": 0.8641747236251831, "2029":... | 13907427 | Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modulates chromatin remains poorly understood. Here we identify the poly(ADP-ribose)-regulated protein APLF as ... | DNA repair factor APLF is a histone chaperone. |
{"1014": 0.4093637466430664, "1017": 0.1384023278951645, "1018": 0.12814582884311676, "1020": 0.16690383851528168, "1021": 0.01934296265244484, "1023": 0.10818854719400406, "1026": 0.08244366943836212, "1044": 0.259204238653183, "1048": 0.24631060659885406, "1052": 0.47827014327049255, "1081": 0.1718502640724182, "2043... | 13907928 | Baseline neurovascular transduction is reduced in normotensive pregnancy; however, little is known about changes to neurovascular transduction during periods of heightened sympathetic activation. We tested the hypothesis that, despite an exacerbated muscle sympathetic nerve activity (microneurography) response to cold ... | Regulation of sympathetic nerve activity during the cold pressor test in normotensive pregnant and nonpregnant women. |
{"1011": 0.21293537318706512, "1015": 0.574020504951477, "1038": 0.9958525896072388, "1052": 0.029824240133166313, "2005": 0.11865071207284927, "2007": 0.25995752215385437, "2008": 0.10818854719400406, "2028": 0.42608439922332764, "2029": 0.3810817003250122, "2034": 0.036437395960092545, "2044": 0.06246116757392883, "2... | 13910150 | Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells. They together initiate epigenetic reprogramming in early germ cells toward an underlying pluripotent state, which is equivalent to embryonic stem cel... | The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells |
{"1011": 0.034552380442619324, "1017": 0.09938567131757736, "1019": 0.08961215615272522, "1052": 0.23015019297599792, "2004": 0.006812678650021553, "2005": 0.08603433519601822, "2008": 0.10906458646059036, "2011": 0.07884006202220917, "2015": 0.2160874605178833, "2024": 0.07431721687316895, "2028": 0.2018241584300995, ... | 13912224 | Evolutionary related multisubunit RNA polymerases (RNAPs) transcribe the genomes of all living organisms. Whereas the core subunits of RNAPs are universally conserved in all three domains of life-indicative of a common evolutionary descent-this only applies to one RNAP-associated transcription factor-Spt5, also known a... | A Nexus for Gene Expression—Molecular Mechanisms of Spt5 and NusG in the Three Domains of Life |
{"1011": 0.175953671336174, "1018": 0.0797421783208847, "1019": 0.0913962796330452, "1020": 0.05046287178993225, "1044": 0.3416208028793335, "1060": 0.6911921501159668, "2000": 0.1710275560617447, "2002": 0.07431721687316895, "2003": 0.08154398202896118, "2005": 0.1994270235300064, "2011": 0.09050461649894714, "2012": ... | 13914198 | High-throughput sequencing technologies produce short sequence reads that can contain phase information if they span two or more heterozygote genotypes. This information is not routinely used by current methods that infer haplotypes from genotype data. We have extended the SHAPEIT2 method to use phase-informative seque... | Haplotype estimation using sequencing reads. |
{"1013": 0.175953671336174, "1062": 0.3824150264263153, "1997": 0.2539152204990387, "1998": 0.175953671336174, "2005": 0.0019512200960889459, "2051": 0.4425300657749176, "2053": 0.24631060659885406, "2062": 0.06154331564903259, "2071": 0.02316705882549286, "2073": 0.17431432008743286, "2084": 0.17759032547473907, "2099... | 13914633 | BACKGROUND HIV and tuberculosis (TB) services are provided free of charge in many sub-Saharan African countries, but patients still incur costs. METHODS Patient-exit interviews were conducted in primary health care clinics in rural South Africa with representative samples of 200 HIV-infected patients enrolled in a pre-... | Time and Money: The True Costs of Health Care Utilization for Patients Receiving "Free" HIV/Tuberculosis Care and Treatment in Rural KwaZulu-Natal. |
{"1037": 0.13925230503082275, "2003": 0.07431721687316895, "2013": 0.0752234235405922, "2047": 0.25088030099868774, "2054": 0.0038986403960734606, "2109": 0.18329764902591705, "2126": 0.036437395960092545, "2129": 0.23402166366577148, "2155": 0.33675122261047363, "2168": 0.9248477816581726, "2170": 0.45623743534088135,... | 13915464 | A system for naming ribosomal proteins is described that the authors intend to use in the future. They urge others to adopt it. The objective is to eliminate the confusion caused by the assignment of identical names to ribosomal proteins from different species that are unrelated in structure and function. In the system... | A new system for naming ribosomal proteins. |
{"1013": 0.1677299439907074, "1039": 0.37907835841178894, "1052": 0.42990362644195557, "1056": 0.5284429788589478, "2003": 0.3339579105377197, "2006": 0.04674193635582924, "2013": 0.15442965924739838, "2023": 0.06612417846918106, "2038": 0.20977331697940826, "2042": 0.04860413447022438, "2043": 0.20501139760017395, "20... | 13916484 | COSMIC (http://www.sanger.ac.uk/cosmic) curates comprehensive information on somatic mutations in human cancer. Release v48 (July 2010) describes over 136,000 coding mutations in almost 542,000 tumour samples; of the 18,490 genes documented, 4803 (26%) have one or more mutations. Full scientific literature curations ar... | COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer |
{"1011": 0.41389304399490356, "1038": 0.2881702482700348, "1042": 0.16524957120418549, "1047": 0.812664806842804, "1050": 1.1363043785095215, "1053": 0.371698260307312, "1056": 0.0317181795835495, "1164": 0.9310253858566284, "2000": 0.11343330889940262, "2003": 0.35745587944984436, "2005": 0.04394211992621422, "2053": ... | 13916951 | Quantitative measurement of NF-kappaB nuclear translocation is an important research tool in cellular immunology. Established methodologies have a number of limitations, such as poor sensitivity, high cost or dependence on cell lines. Novel imaging methods to measure nuclear translocation of transcriptionally active co... | Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages |
{"1022": 0.3683255612850189, "1043": 0.5461324453353882, "1052": 0.5410289764404297, "1996": 0.012615402229130268, "1997": 0.09584271162748337, "1998": 0.28082266449928284, "2005": 0.0058422754518687725, "2012": 0.18492233753204346, "2013": 0.09495500475168228, "2015": 0.053244512528181076, "2024": 0.19541899859905243,... | 13921526 | The major cell classes of the brain differ in their developmental processes, metabolism, signaling, and function. To better understand the functions and interactions of the cell types that comprise these classes, we acutely purified representative populations of neurons, astrocytes, oligodendrocyte precursor cells, new... | An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. |
{"1011": 0.22079704701900482, "1021": 0.0058422754518687725, "1039": 1.0229004621505737, "1043": 0.9162907600402832, "1048": 0.021256839856505394, "2007": 0.013579257763922215, "2011": 0.32129061222076416, "2012": 0.6950984001159668, "2029": 0.35334911942481995, "2048": 0.06612417846918106, "2069": 0.8117979168891907, ... | 13921783 | An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins generated by repeat-associated, non-ATG translation. To address this quest... | C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins |
{"1011": 0.27712854743003845, "1016": 0.037378571927547455, "1018": 0.03925827145576477, "1042": 0.8057082891464233, "1043": 0.4196864068508148, "1050": 0.4938860833644867, "2003": 0.0797421783208847, "2005": 0.12642613053321838, "2011": 0.24859806895256042, "2012": 0.7086513638496399, "2015": 0.17922431230545044, "202... | 13923069 | Chronic, nonresolving inflammation is a critical factor in the clinical progression of advanced atherosclerotic lesions. In the normal inflammatory response, resolution is mediated by several agonists, among which is the glucocorticoid-regulated protein called annexin A1. The proresolving actions of annexin A1, which a... | Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice |
{"1009": 0.32270604372024536, "1011": 0.3127557039260864, "1016": 0.574020504951477, "1017": 0.41840189695358276, "1040": 0.06886265426874161, "1045": 0.013579257763922215, "1056": 0.8004589080810547, "2004": 0.0842406153678894, "2006": 0.11951763927936554, "2007": 0.175953671336174, "2011": 0.24171993136405945, "2013"... | 13923140 | Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory cytokine interleukin-2 (IL-2). In order to tes... | Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity |
{"1011": 0.3177432417869568, "1015": 0.5855054259300232, "1042": 0.6734226942062378, "1043": 0.7565253376960754, "1052": 0.7163142561912537, "1996": 0.09317722171545029, "1999": 0.22157983481884003, "2003": 0.2478361576795578, "2007": 0.1332872211933136, "2008": 0.24325250089168549, "2028": 0.3005385100841522, "2029": ... | 13931771 | Various specialized domains have been described in the cytosol and the nucleus; however, little is known about compartmentalization within the mitochondrial matrix. GRSF1 (G-rich sequence factor 1) is an RNA binding protein that was previously reported to localize in the cytosol. We found that an isoform of GRSF1 accum... | GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules |
{"1014": 0.22392450273036957, "1038": 0.23787821829319, "1047": 0.05139094591140747, "1609": 0.2394166737794876, "2001": 0.10026945173740387, "2004": 0.2561853528022766, "2020": 0.045809537172317505, "2043": 0.16276304423809052, "2076": 0.11604541540145874, "2077": 0.1384023278951645, "2086": 0.3084607720375061, "2094"... | 13933299 | Aims: To investigate midlife cholesterol in relation to Alzheimer’s disease (AD) and vascular dementia (VaD) in a large multiethnic cohort of women and men. Methods: The Kaiser Permanente Northern California Medical Group (healthcare delivery organization) formed the database for this study. The 9,844 participants unde... | Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later |
{"1003": 0.23247487843036652, "1022": 0.06337817758321762, "1052": 0.1384023278951645, "1997": 0.23864774405956268, "2004": 0.22704219818115234, "2007": 0.052318159490823746, "2012": 0.16110190749168396, "2013": 0.176772341132164, "2020": 0.00875066313892603, "2035": 0.3750596046447754, "2058": 0.07612881064414978, "20... | 13934676 | BACKGROUND The number of older people is set to increase dramatically worldwide. Demographic changes are likely to result in the rise of age-related chronic diseases which largely contribute to years lived with a disability and future dependence. However dependence is much less studied although intrinsically linked to ... | "The contribution of chronic diseases to the prevalence of dependence among older people in Latin America, China and India: a 10/66 Dementia Research Group population-based survey" |
{"1996": 0.02316705882549286, "2003": 0.0058422754518687725, "2005": 0.011650617234408855, "2011": 0.319873183965683, "2012": 0.5506471395492554, "2025": 0.3381449282169342, "2026": 0.8989537954330444, "2033": 0.012615402229130268, "2046": 0.34023189544677734, "2064": 0.22001366317272186, "2066": 0.026976587250828743, ... | 13936152 | Partitioning tissues into compartments that do not intermix is essential for the correct morphogenesis of animal embryos and organs. Several hypotheses have been proposed to explain compartmental cell sorting, mainly differential adhesion, but also regulation of the cytoskeleton or of cell proliferation. Nevertheless, ... | An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos |
{"1011": 0.0174254160374403, "1019": 0.32341301441192627, "1020": 0.23402166366577148, "1037": 0.11517547070980072, "1048": 0.10026945173740387, "1997": 0.05694137513637543, "2000": 0.020300358533859253, "2005": 0.08513788133859634, "2022": 0.1477125883102417, "2035": 0.17840765416622162, "2043": 0.11081436276435852, "... | 13938878 | We conducted a study to determine whether clinical algorithms would be useful in malaria diagnosis among people living in an area of moderate malaria transmission within Kilifi District in Kenya. A total of 1602 people of all age groups participated. We took smears and recorded clinical signs and symptoms (prompted or ... | Clinical algorithms for malaria diagnosis lack utility among people of different age groups. |
{"1015": 0.791648268699646, "1016": 0.47827014327049255, "1045": 0.18167030811309814, "1052": 0.2231435477733612, "1055": 0.6522845029830933, "1056": 0.8074519634246826, "2007": 0.0029254043474793434, "2015": 0.0174254160374403, "2028": 0.38574060797691345, "2029": 0.20660123229026794, "2048": 0.14349138736724854, "205... | 13940200 | Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing replication, the localization of the causal variant(s) requires comprehensive resequencing, extensive genotyping and statistical analyses in large sample sets leading to targeted functional studies.... | Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes |
{"1015": 0.20022670924663544, "1020": 0.10818854719400406, "1039": 0.44566190242767334, "1062": 0.32058215141296387, "1081": 0.5762182474136353, "2011": 0.04953393340110779, "2020": 0.14179791510105133, "2043": 0.004870930220931768, "2049": 0.13157635927200317, "2057": 0.6202403903007507, "2058": 0.13157635927200317, "... | 13944805 | KEY POINTS Maternal obesity reduces adipogenic progenitor density in offspring adipose tissue. The ability of adipose tissue expansion in the offspring of obese mothers is limited and is associated with metabolic dysfunction of adipose tissue when challenged with a high-fat diet. Maternal obesity induces DNA demethylat... | Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. |
{"1011": 0.03925827145576477, "1999": 0.11604541540145874, "2003": 0.22626367211341858, "2004": 0.0797421783208847, "2005": 0.42353010177612305, "2011": 0.06886265426874161, "2013": 0.16110190749168396, "2020": 0.13925230503082275, "2024": 0.2105647772550583, "2053": 0.04860413447022438, "2073": 0.22157983481884003, "2... | 13948920 | Artemisinin-based combination therapies are the frontline treatment of Plasmodium falciparum malaria. The circulation of falsified and substandard artemisinin-based antimalarials in Southeast Asia has been a major predicament for the malaria elimination campaign. To provide an update of this situation, we purchased 153... | Quality Testing of Artemisinin-Based Antimalarial Drugs in Myanmar. |
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