spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.32199856638908386, "1015": 0.9162907600402832, "1042": 0.554580807685852, "1045": 0.010684899985790253, "1048": 1.1487655639648438, "1999": 0.09050461649894714, "2008": 0.18978065252304077, "2013": 0.31132611632347107, "2015": 0.6054253578186035, "2020": 0.1510767638683319, "2024": 0.06795065850019455, "2025... | 13949015 | Highly active (i.e., "hot") long interspersed element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransposition activity in the human genome; however, the abundance of hot L1s in the human population remains largely unexplored. Here, we used a fosmid-based, paired-end DNA sequencing strategy to identify 68 ful... | LINE-1 Retrotransposition Activity in Human Genomes |
{"1011": 0.06429435312747955, "1999": 0.6233867406845093, "2000": 0.009718249551951885, "2003": 0.13243216276168823, "2005": 0.13925230503082275, "2011": 0.2954642176628113, "2013": 0.11256109178066254, "2046": 0.1602703034877777, "2054": 0.06703783571720123, "2064": 0.09317722171545029, "2076": 0.16276304423809052, "2... | 13952658 | Metastatic disease is the major cause of death from cancer, and immunotherapy and chemotherapy have had limited success in reversing its progression. Data from mouse models suggest that the recruitment of immunosuppressive cells to tumours protects metastatic cancer cells from surveillance by killer cells, which nullif... | Immune cell promotion of metastasis |
{"1011": 0.11256109178066254, "1015": 0.06612417846918106, "1038": 0.6867793202400208, "1052": 0.21530038118362427, "1055": 0.10993985831737518, "1057": 1.0986123085021973, "1996": 0.11951763927936554, "1997": 0.11951763927936554, "1999": 0.025073638185858727, "2002": 0.7701805830001831, "2008": 0.04767346754670143, "2... | 13953762 | The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase bridges (UFBs) in mitosis alongside a complex of DNA repair proteins, including the Bloom's syndrome protein (BLM). However, very little is known about the function of PICH or how it is recruited to UFBs. Using a combination of micr... | PICH: a DNA translocase specially adapted for processing anaphase bridge DNA. |
{"1011": 0.41195443272590637, "1020": 0.09584271162748337, "1041": 0.42225050926208496, "1043": 0.18573370575904846, "1052": 0.17922431230545044, "1060": 0.48670899868011475, "1997": 0.00875066313892603, "1999": 0.06977381557226181, "2007": 0.010684899985790253, "2008": 0.1064341589808464, "2029": 0.29400965571403503, ... | 13955536 | Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are largely unknown. We have carried out whole-genome bisulfite sequencing (BS-Seq) and RNA-Seq across key stages from E6.5 epiblast to E16.5 PGCs. Global ... | The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells |
{"1008": 0.472198486328125, "1011": 0.2637155055999756, "1015": 0.02412080205976963, "1021": 0.026025565341114998, "1037": 0.436867892742157, "1038": 0.7305257320404053, "1040": 0.5461324453353882, "1044": 0.9317949414253235, "1049": 0.6634125709533691, "1055": 0.6980181336402893, "2002": 0.3170322775840759, "2003": 0.... | 13956305 | Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and contr... | Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 |
{"1011": 0.15023678541183472, "1016": 0.6629094481468201, "1048": 0.08692999184131622, "1052": 0.23247487843036652, "1056": 0.6420594453811646, "1057": 0.5127768516540527, "1060": 0.4879087805747986, "1156": 1.0748957395553589, "2011": 0.15275461971759796, "2012": 0.3005385100841522, "2048": 0.24325250089168549, "2075"... | 13958154 | Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA sequencing to map transcripts expressed in five palmitate-treated human islet prepa... | RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. |
{"1014": 0.4709797203540802, "1042": 0.4311734735965729, "1048": 0.5979346632957458, "1052": 0.8340972661972046, "2004": 0.7086513638496399, "2005": 0.015504186972975731, "2007": 0.151916041970253, "2012": 0.07068414986133575, "2029": 0.06429435312747955, "2051": 0.1485546976327896, "2064": 0.18329764902591705, "2073":... | 13959707 | BACKGROUND Plasmodium falciparum malaria remains a major cause of illness and death in sub-Saharan Africa. Young children bear the brunt of the disease and though older children and adults suffer relatively fewer clinical attacks, they remain susceptible to asymptomatic P. falciparum infection. A better understanding o... | The Ratio of Monocytes to Lymphocytes in Peripheral Blood Correlates with Increased Susceptibility to Clinical Malaria in Kenyan Children |
{"1011": 0.08513788133859634, "1037": 0.1602703034877777, "1043": 0.47463157773017883, "1996": 0.30989447236061096, "2003": 0.3656192123889923, "2011": 0.15359249711036682, "2029": 0.04207121208310127, "2043": 0.07793712615966797, "2048": 0.5707147121429443, "2064": 0.026025565341114998, "2075": 0.1384023278951645, "20... | 13963620 | Dorsal closure is a paradigm epithelial fusion episode that occurs late in Drosophila embryogenesis and leads to sealing of a midline hole by bonding of two opposing epithelial sheets. The leading edge epithelial cells express filopodia and fusion is dependent on interdigitation of these filopodia to prime formation of... | Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure. |
{"1005": 0.19622190296649933, "1011": 0.3070250153541565, "1017": 0.6679295301437378, "1018": 0.37907835841178894, "1058": 0.03925827145576477, "2003": 0.10379679501056671, "2007": 0.18978065252304077, "2008": 0.11256109178066254, "2015": 0.2652147710323334, "2024": 0.3297532796859741, "2029": 0.259204238653183, "2038"... | 13964633 | BACKGROUND Mature microRNAs (miRNAs) are single-stranded RNAs that regulate post-transcriptional gene expression. In our previous study, we have shown that versican 3'UTR, a fragment of non-coding transcript, has the ability to antagonize miR-199a-3p function thereby regulating expression of the matrix proteins versica... | Expression of Versican 3′-Untranslated Region Modulates Endogenous MicroRNA Functions |
{"1011": 0.37035053968429565, "1038": 0.47158926725387573, "1039": 0.26296505331993103, "1044": 0.6613984704017639, "1045": 0.5718178153038025, "1052": 0.8450632095336914, "2002": 0.8845420479774475, "2003": 0.22704219818115234, "2005": 0.49626702070236206, "2007": 0.4337083101272583, "2029": 0.23402166366577148, "2063... | 13965483 | Epitope vaccine based on the enzyme urease of Helicobacter pylori is a promising option for prophylactic and therapeutic vaccination against H. pylori infection. In our previous study, the epitope vaccine CTB-UA, which was composed of the mucosal adjuvant cholera toxin B subunit (CTB) and an epitope (UreA183–203) from ... | Prophylactic and therapeutic efficacy of the epitope vaccine CTB-UA against Helicobacter pylori infection in a BALB/c mice model |
{"1003": 0.1510767638683319, "1014": 0.19220098853111267, "1020": 0.27044451236724854, "1022": 0.026976587250828743, "1042": 0.4891071021556854, "1055": 0.0752234235405922, "1056": 0.35334911942481995, "1057": 0.39893341064453125, "1999": 0.055094651877880096, "2004": 0.48068851232528687, "2007": 0.026025565341114998, ... | 13966946 | OBJECTIVE To determine spatial patterns of co-endemicity of schistosomiasis mansoni and the soil-transmitted helminths (STHs) Ascaris lumbricoides, Trichuris trichiura and hookworm in the Great Lakes region of East Africa, to help plan integrated neglected tropical disease programmes in this region. METHOD Parasitologi... | Spatial co-distribution of neglected tropical diseases in the east African great lakes region: revisiting the justification for integrated control. |
{"1011": 0.09761575609445572, "1023": 0.4425300657749176, "1039": 0.3177432417869568, "1045": 0.7076893448829651, "1048": 0.7038320899009705, "1055": 0.004870930220931768, "2002": 0.42735910415649414, "2013": 0.18492233753204346, "2015": 0.15442965924739838, "2044": 0.34922540187835693, "2046": 0.29328158497810364, "20... | 13969173 | Amyotrophic lateral sclerosis (ALS) causes motor neuron degeneration, paralysis, and death. Accurate disease modeling, identifying disease mechanisms, and developing therapeutics is urgently needed. We previously reported motor neuron toxicity through postmortem ALS spinal cord-derived astrocytes. However, these cells ... | Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. |
{"1011": 0.16442140936851501, "1044": 0.24631060659885406, "2000": 0.04394211992621422, "2002": 0.011650617234408855, "2007": 0.41065993905067444, "2028": 0.058784693479537964, "2029": 0.1384023278951645, "2060": 0.07431721687316895, "2064": 0.043007105588912964, "2109": 0.14686977863311768, "2178": 0.18492233753204346... | 13980338 | Heterogeneity within the self-renewal durability of adult hematopoietic stem cells (HSCs) challenges our understanding of the molecular framework underlying HSC function. Gene expression studies have been hampered by the presence of multiple HSC subtypes and contaminating non-HSCs in bulk HSC populations. To gain deepe... | Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations |
{"1011": 0.13157635927200317, "2001": 0.00875066313892603, "2008": 0.04674193635582924, "2011": 0.14518201351165771, "2029": 0.175953671336174, "2035": 0.022212404757738113, "2063": 1.0298984050750732, "2106": 0.12556517124176025, "2109": 0.43623676896095276, "2179": 0.1685553640127182, "2224": 0.09850110858678818, "22... | 13989491 | Humans expressing a defective form of the transcription factor AIRE (autoimmune regulator) develop multiorgan autoimmune disease. We used aire- deficient mice to test the hypothesis that this transcription factor regulates autoimmunity by promoting the ectopic expression of peripheral tissue- restricted antigens in med... | Acids: Structures, Properties, and Functions (University Science Books, Sausalito, CA, 2000). |
{"1011": 0.055094651877880096, "1041": 0.2822965085506439, "1062": 0.672426164150238, "1996": 0.030771657824516296, "1998": 0.043007105588912964, "1999": 0.06795065850019455, "2005": 0.14939609169960022, "2007": 0.06886265426874161, "2011": 0.25694093108177185, "2012": 0.14518201351165771, "2029": 0.20022670924663544, ... | 13992047 | We have found that epithelial cells engage in a process of cadherin-mediated intercellular adhesion that utilizes calcium and actin polymerization in unexpected ways. Calcium stimulates filopodia, which penetrate and embed into neighboring cells. E-cadherin complexes cluster at filopodia tips, generating a two-rowed zi... | Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion |
{"1054": 0.1485546976327896, "1998": 0.0317181795835495, "2003": 0.2105647772550583, "2049": 0.2470736801624298, "2054": 0.04113444685935974, "2055": 0.043007105588912964, "2057": 0.1229778528213501, "2062": 0.14686977863311768, "2064": 0.3547199070453644, "2071": 0.02412080205976963, "2084": 0.4437839686870575, "2087"... | 14019636 | Ribosomal DNA is one of the most variable regions in the human genome with respect to copy number. Despite the importance of rDNA for cellular function, we know virtually nothing about what governs its copy number, stability, and sequence in the mammalian genome due to challenges associated with mapping and analysis. W... | Ribosomal DNA copy number loss and sequence variation in cancer |
{"1011": 0.0038986403960734606, "1014": 0.4337083101272583, "1042": 0.11081436276435852, "1054": 0.08244366943836212, "1059": 0.3134697377681732, "1081": 0.7067264318466187, "1999": 0.2983669638633728, "2000": 0.03831886500120163, "2001": 0.03831886500120163, "2012": 0.35813871026039124, "2020": 0.02316705882549286, "2... | 14021596 | BACKGROUND The objective of the study was to test the hypothesis that elevated red cell distribution width (RDW) at admission increases the risk of mortality in older patients admitted to the emergency department (ED). METHODS We performed a retrospective analysis of patients admitted to the ED between May 2013 and Oct... | The association of Red cell distribution width and in-hospital mortality in older adults admitted to the emergency department |
{"1011": 0.30989447236061096, "1048": 0.9710156321525574, "2003": 0.06703783571720123, "2005": 0.02316705882549286, "2011": 0.11604541540145874, "2015": 0.4412745535373688, "2024": 0.24401791393756866, "2029": 0.18248429894447327, "2035": 0.3262358605861664, "2050": 0.2317005842924118, "2052": 0.11430477350950241, "205... | 14050257 | Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in the mouse and human transcriptomes. Two important questions are whether all lncRNAs are functional and how they could exert a function. Several lncRNAs have been shown to function through their product, but this is not the only po... | Gene regulation by the act of long non-coding RNA transcription |
{"1044": 0.2689530849456787, "1999": 0.004870930220931768, "2001": 0.11604541540145874, "2011": 0.06977381557226181, "2026": 1.2336074113845825, "2033": 0.2231435477733612, "2037": 0.06795065850019455, "2038": 0.07431721687316895, "2042": 0.319873183965683, "2043": 0.034552380442619324, "2046": 0.1734936386346817, "204... | 14060030 | The recognition that myocyte mitosis occurs in the fetal, neonatal, adult, and hypertrophied heart and that a pool of primitive, undifferentiated cells is present in the myocardium has put forward a different view of the biology of the heart. The new paradigm suggests that myocyte formation is preserved during postnata... | Life and death of cardiac stem cells: a paradigm shift in cardiac biology. |
{"1052": 0.3464667797088623, "1998": 0.29619070887565613, "2003": 0.17840765416622162, "2007": 0.1905880719423294, "2029": 0.04953393340110779, "2064": 0.39433568716049194, "2067": 1.02149498462677, "2076": 0.1332872211933136, "2079": 0.07793712615966797, "2089": 0.1905880719423294, "2090": 0.6338034868240356, "2102": ... | 14075252 | Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back loop may be operative between platelets and tumor cells, with reciprocal interactions between tumor growth/metastasis and thrombocytosis/platelet activation. ... | Paraneoplastic thrombocytosis: the secrets of tumor self-promotion. |
{"1028": 0.056018441915512085, "1048": 0.043007105588912964, "2034": 0.3963087201118469, "2039": 0.27934664487838745, "2044": 0.3318578004837036, "2048": 0.15943801403045654, "2051": 0.013579257763922215, "2075": 0.43875885009765625, "2086": 0.06977381557226181, "2092": 0.12814582884311676, "2109": 0.2470736801624298, ... | 14079881 | OBJECTIVE To determine whether perceived age correlates with survival and important age related phenotypes. DESIGN Follow-up study, with survival of twins determined up to January 2008, by which time 675 (37%) had died. SETTING Population based twin cohort in Denmark. PARTICIPANTS 20 nurses, 10 young men, and 11 older ... | Perceived age as clinically useful biomarker of ageing: cohort study. |
{"1009": 0.34715715050697327, "1017": 0.3723714053630829, "1019": 0.04207121208310127, "1999": 0.1946154683828354, "2004": 0.2837681770324707, "2006": 0.8004589080810547, "2010": 0.6892333030700684, "2011": 0.07431721687316895, "2020": 0.15275461971759796, "2026": 0.6674286723136902, "2029": 0.016465263441205025, "2034... | 14082855 | PURPOSE To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model. MATERIALS AND METHODS Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed ... | Inflammatory Reaction as Determinant of Foreign Body Reaction Is an Early and Susceptible Event after Mesh Implantation |
{"1054": 0.3019835948944092, "1062": 0.31845372915267944, "1996": 0.11951763927936554, "2003": 0.18816383183002472, "2005": 0.2470736801624298, "2008": 0.06703783571720123, "2015": 0.11778303235769272, "2029": 0.06154331564903259, "2047": 0.6139179468154907, "2048": 0.28082266449928284, "2051": 0.42608439922332764, "20... | 14083283 | We present a new compact image pyramid representation, the Riesz pyramid, that can be used for real-time phase-based motion magnification. Our new representation is less overcomplete than even the smallest two orientation, octave-bandwidth complex steerable pyramid, and can be implemented using compact, efficient linea... | Riesz pyramids for fast phase-based video magnification |
{"1011": 0.5016035437583923, "1015": 0.14349138736724854, "1038": 0.5773153901100159, "1040": 0.4673144817352295, "1046": 0.11604541540145874, "1048": 0.44753631949424744, "1055": 0.09406650811433792, "1155": 1.1192315816879272, "1999": 0.1734936386346817, "2003": 0.22079704701900482, "2011": 0.40546512603759766, "2015... | 14092737 | α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and spread are poorly characterize... | Alpha-Synuclein Induces Lysosomal Rupture and Cathepsin Dependent Reactive Oxygen Species Following Endocytosis |
{"1049": 0.20977331697940826, "1999": 0.13243216276168823, "2033": 0.9178520441055298, "2045": 0.1718502640724182, "2064": 0.1510767638683319, "2098": 0.11256109178066254, "2129": 0.13755162060260773, "2158": 0.030771657824516296, "2179": 0.020300358533859253, "2218": 0.05786345899105072, "2287": 0.32553088665008545, "... | 14103509 | A mechanistic understanding of fracture in human bone is critical to predicting fracture risk associated with age and disease. Despite extensive work, a mechanistic framework for describing how the microstructure affects the failure of bone is lacking. Although micromechanical models incorporating local failure criteri... | Mechanistic Fracture Criteria For The Failure Of Human Cortical Bone |
{"1014": 0.09228714555501938, "1040": 1.0628231763839722, "1166": 0.09672962874174118, "1999": 0.151916041970253, "2000": 0.02316705882549286, "2001": 0.20977331697940826, "2005": 0.32905077934265137, "2006": 0.08603433519601822, "2010": 0.684319257736206, "2013": 0.1619328260421753, "2020": 0.10731173306703568, "2029"... | 14105446 | In this experiment actinomycin D was used to explore the action of the wound epidermis on underlying tissues during limb regeneration. In axolotl forelimbs the skin was removed from the elbow to the shoulder. Skin from the right limbs was soaked for three hours in actinomycin D (5.0 or 10.0 μg/ml 0.6% NaCl). For contro... | Inhibition of limb regeneration in the axolotl after treatment of the skin with actinomycin D. |
{"1011": 0.1602703034877777, "1054": 0.4770587682723999, "2002": 0.6634125709533691, "2004": 0.07793712615966797, "2005": 0.0797421783208847, "2008": 0.09495500475168228, "2011": 0.31560876965522766, "2029": 0.30917787551879883, "2050": 0.1212492436170578, "2079": 0.22626367211341858, "2089": 0.0913962796330452, "2090"... | 14116046 | Retinoic acid-related orphan receptors RORα and RORγ play a regulatory role in lipid/glucose homeostasis and various immune functions, and have been implicated in metabolic syndrome and several inflammatory diseases. RORα-deficient mice are protected against age- and diet-induced obesity, hepatosteatosis, and insulin r... | Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity |
{"1049": 0.06429435312747955, "2000": 0.3084607720375061, "2005": 0.11517547070980072, "2006": 0.018384648486971855, "2011": 0.11604541540145874, "2015": 0.841701865196228, "2022": 0.12728634476661682, "2039": 0.4145384132862091, "2040": 0.07159364968538284, "2057": 0.15023678541183472, "2062": 0.19381128251552582, "20... | 14118484 | A collaboration of multidisciplinary experts on the functional evaluation of lung cancer patients has been facilitated by the European Respiratory Society (ERS) and the European Society of Thoracic Surgery (ESTS), in order to draw up recommendations and provide clinicians with clear, up-to-date guidelines on fitness fo... | ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). |
{"1011": 0.11778303235769272, "1049": 0.040196798741817474, "1060": 0.5104349255561829, "1997": 0.025073638185858727, "1999": 0.09228714555501938, "2001": 0.22548456490039825, "2003": 0.1619328260421753, "2007": 0.347847044467926, "2008": 0.15442965924739838, "2011": 0.3923587501049042, "2029": 0.45932671427726746, "20... | 14119470 | Ran is an abundant nuclear GTPase with a clear role in nuclear transport during interphase but with roles in mitotic regulation that are less well understood. The nucleotide-binding state of Ran is regulated by a GTPase activating protein, RanGAP1, and by a guanine nucleotide exchange factor, RCC1. Ran also interacts w... | The Ran GTPase regulates mitotic spindle assembly |
{"1015": 0.30989447236061096, "1019": 0.4855078160762787, "1022": 0.17759032547473907, "1023": 0.48670899868011475, "1040": 0.06337817758321762, "1044": 0.6296497583389282, "1052": 0.14939609169960022, "2004": 0.1693800985813141, "2005": 0.34300774335861206, "2007": 0.2034190446138382, "2011": 0.016465263441205025, "20... | 14121786 | BACKGROUND Epidemiologic analysis of family data on blood pressure (BP) is often compromised by the effects of antihypertensive medications. A review of numerous clinical trials that investigated the effects of BP-lowering medications is summarized here. METHODS Published clinical trials, including 137 clinical trials ... | A summary of the effects of antihypertensive medications on measured blood pressure. |
{"1052": 0.08244366943836212, "1996": 0.21214580535888672, "1998": 0.1229778528213501, "2013": 0.5139457583427429, "2024": 0.037378571927547455, "2029": 0.32270604372024536, "2042": 0.06246116757392883, "2045": 0.2696990668773651, "2048": 0.5139457583427429, "2061": 0.804835319519043, "2064": 0.0009760859538801014, "20... | 14128314 | The recent derivation of pluripotent stem cell lines from a number of different sources, including reprogrammed adult somatic cells, raises the issue of the developmental equivalence of these different pluripotent states. At least two different states representing the epiblast progenitors in the blastocyst and the plur... | Stem Cells and Early Lineage Development |
{"1011": 0.27786844968795776, "1998": 0.7426811456680298, "2004": 0.16524957120418549, "2007": 0.011650617234408855, "2010": 0.49982786178588867, "2029": 0.12728634476661682, "2080": 0.6441128253936768, "2083": 0.08603433519601822, "2089": 0.06612417846918106, "2090": 0.31560876965522766, "2110": 0.45251765847206116, "... | 14131683 | An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to absent AR expression and often have neuroendocrine features. The etiology and molecular basis for this 'alternative' treatment-resistant c... | Divergent clonal evolution of castration resistant neuroendocrine prostate cancer |
{"1011": 0.07068414986133575, "1015": 0.03360854089260101, "1016": 0.03360854089260101, "1038": 0.6451379656791687, "1043": 0.6543170213699341, "1047": 0.15777134895324707, "1049": 0.6471850275993347, "1052": 0.32270604372024536, "1055": 0.9546096324920654, "1998": 0.3910386264324188, "2007": 0.09495500475168228, "2011... | 14145440 | BACKGROUND DNA replication and mitosis are triggered by activation of kinase complexes, each made up of a cyclin and a cyclin-dependent kinase (Cdk). It had seemed possible that the association of Cdks with different classes of cyclins specifies whether S phase (replication) or M phase (mitosis) will occur. The recent ... | S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state |
{"1011": 0.35060185194015503, "1040": 0.00875066313892603, "1041": 1.1325355768203735, "1052": 0.4196864068508148, "2005": 0.02792670577764511, "2011": 0.39893341064453125, "2012": 0.07793712615966797, "2029": 0.2561853528022766, "2038": 0.018384648486971855, "2043": 0.0354953333735466, "2050": 0.30558720231056213, "20... | 14149065 | E-cadherin has been linked to the suppression of tumor growth and the inhibition of cell proliferation in culture. We observed that progressively decreasing the seeding density of normal rat kidney-52E (NRK-52E) or MCF-10A epithelial cells from confluence, indeed, released cells from growth arrest. Unexpectedly, a furt... | E-cadherin engagement stimulates proliferation via Rac1 |
{"1011": 0.20421554148197174, "1022": 0.5707147121429443, "1044": 0.32341301441192627, "1996": 0.0797421783208847, "1997": 0.09050461649894714, "1999": 0.5267143249511719, "2003": 0.07884006202220917, "2007": 0.09050461649894714, "2010": 0.3409265875816345, "2015": 0.09406650811433792, "2024": 0.2561853528022766, "2029... | 14155726 | Nuclear actin-related proteins (Arps) are subunits of several chromatin remodelers, but their molecular functions within these complexes are unclear. We report the crystal structure of the INO80 complex subunit Arp8 in its ATP-bound form. Human Arp8 has several insertions in the conserved actin fold that explain its in... | Structure of Actin-related protein 8 and its contribution to nucleosome binding |
{"1011": 0.4574742913246155, "1043": 0.8247235417366028, "1055": 1.0023250579833984, "1156": 0.25088030099868774, "2004": 0.020300358533859253, "2007": 0.10906458646059036, "2011": 0.41840189695358276, "2012": 0.0058422754518687725, "2015": 0.2317005842924118, "2024": 0.07341018319129944, "2029": 0.2223619967699051, "2... | 14171859 | beta-adrenergic receptors (beta-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target receptors for internalization. Nitric oxide (NO) and/or S-nitrosothiols (SNOs) can prevent the loss of... | Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2 |
{"1011": 0.04207121208310127, "1013": 0.08692999184131622, "1023": 0.4132472574710846, "1062": 0.7163142561912537, "1998": 0.05786345899105072, "2000": 0.09495500475168228, "2005": 0.1619328260421753, "2015": 0.20102575421333313, "2029": 0.07612881064414978, "2038": 0.034552380442619324, "2046": 0.49864232540130615, "2... | 14174055 | Recent use of the CRISPR/Cas9 system has dramatically reduced the time required to produce mutant mice, but the involvement of a time-consuming microinjection step still hampers its application for high-throughput genetic analysis. Here we developed a simple, highly efficient, and large-scale genome editing method, in ... | Electroporation enables the efficient mRNA delivery into the mouse zygotes and facilitates CRISPR/Cas9-based genome editing |
{"1011": 0.18573370575904846, "1037": 0.5568217039108276, "1044": 0.8383291959762573, "1053": 0.0058422754518687725, "1998": 0.0752234235405922, "2002": 0.20580662786960602, "2007": 0.11604541540145874, "2011": 0.0354953333735466, "2012": 0.17922431230545044, "2013": 0.32058215141296387, "2015": 0.8813109993934631, "20... | 14178995 | The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms that can be viewed as accelerated aging. The mechanism by which accumulation o... | Summary |
{"1006": 0.2830325961112976, "1011": 0.21372433006763458, "1039": 0.6420594453811646, "1041": 0.5267143249511719, "2000": 0.09761575609445572, "2003": 0.0913962796330452, "2005": 0.0842406153678894, "2006": 0.04394211992621422, "2029": 0.0058422754518687725, "2046": 0.15023678541183472, "2047": 0.3443928062915802, "206... | 14180217 | A new technique for the automated tracing of protein chains in experimental electron-density maps is described. The technique relies on the repeated application of an oriented electron-density likelihood target function to identify likely C(alpha) positions. This function is applied both in the location of a few promis... | The Buccaneer software for automated model building. 1. Tracing protein chains. |
{"1011": 0.037378571927547455, "1014": 0.2741633653640747, "1022": 0.1710275560617447, "1041": 0.0752234235405922, "1043": 0.841701865196228, "1052": 0.304147332906723, "1053": 0.5596157908439636, "1056": 0.1970241367816925, "1057": 0.7436100244522095, "2005": 0.08961215615272522, "2011": 0.030771657824516296, "2020": ... | 14180565 | Glioblastoma, the most aggressive and malignant form of glioma, appears to be resistant to various chemotherapeutic agents. Hence, approaches have been intensively investigated to targeti specific molecular pathways involved in glioblastoma development and progression. Aloe emodin is believed to modulate the expression... | Expression profile of genes modulated by Aloe emodin in human U87 glioblastoma cells. |
{"1043": 0.861702561378479, "1997": 0.04207121208310127, "2003": 0.3191637098789215, "2005": 0.036437395960092545, "2013": 0.0009760859538801014, "2024": 0.02412080205976963, "2038": 0.0797421783208847, "2050": 0.3995884954929352, "2063": 0.02887592278420925, "2078": 0.0317181795835495, "2110": 0.15526613593101501, "21... | 14185503 | BACKGROUND Genlisea aurea (Lentibulariaceae) is a carnivorous plant with unusually small genome size - 63.6 Mb - one of the smallest known among higher plants. Data on the genome sizes and the phylogeny of Genlisea suggest that this is a derived state within the genus. Thus, G. aurea is an excellent model organism for ... | The miniature genome of a carnivorous plant Genlisea aurea contains a low number of genes and short non-coding sequences |
{"1011": 0.37102460861206055, "1015": 0.678390383720398, "1047": 0.6112717390060425, "1048": 0.41840189695358276, "1999": 0.17431432008743286, "2008": 0.0058422754518687725, "2015": 0.015504186972975731, "2028": 0.26296505331993103, "2029": 0.20818853378295898, "2076": 0.0058422754518687725, "2079": 0.20102575421333313... | 14188138 | In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams syndrome, a mental disorder with profound deficits in visuospatial cognition. However, the in vivo function of this family of... | Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice |
{"1011": 0.2763880789279938, "1019": 0.5784112811088562, "1044": 0.03266380727291107, "1059": 0.9440274834632874, "1996": 0.07159364968538284, "2005": 0.13670019805431366, "2007": 0.2184450328350067, "2008": 0.04487626627087593, "2011": 0.33605360984802246, "2015": 0.05694137513637543, "2029": 0.31845372915267944, "206... | 14191255 | The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical for self-renewal maintenance. However, it remains unclear whether these networks functionally interact and, if so, what factors mediate such interactions. Here, we show that WD repeat domain 5 (Wdr5), a core member of the mammali... | Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network |
{"1018": 0.2018241584300995, "1039": 0.48970574140548706, "1043": 0.4349733293056488, "1047": 0.5080875158309937, "2005": 0.20501139760017395, "2011": 0.1229778528213501, "2015": 0.9037119746208191, "2020": 0.00875066313892603, "2026": 0.7239188551902771, "2029": 0.0038986403960734606, "2046": 0.5651806592941284, "2064... | 14192687 | The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major complication in current transplantation medicine. It was recently shown that the four transcription factors Oct4, Sox2, Klf4, and c-Myc ... | Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. |
{"1011": 0.00875066313892603, "1996": 0.21687394380569458, "1999": 0.0797421783208847, "2029": 0.1401015669107437, "2043": 0.08782484382390976, "2049": 0.3127557039260864, "2073": 0.21530038118362427, "2075": 0.07793712615966797, "2076": 0.6813592314720154, "2077": 0.06429435312747955, "2079": 0.129004567861557, "2090"... | 14195528 | The role of primate frontal cortex in vocal communication and its significance in language evolution have a controversial history. While evidence indicates that vocalization processing occurs in ventrolateral prefrontal cortex neurons, vocal-motor activity has been conjectured to be primarily subcortical and suggestive... | Responses of primate frontal cortex neurons during natural vocal communication. |
{"1016": 0.812664806842804, "1043": 0.10906458646059036, "1044": 0.09938567131757736, "1048": 0.16110190749168396, "1052": 0.7076893448829651, "1998": 0.036437395960092545, "2002": 1.0688776969909668, "2003": 0.02316705882549286, "2004": 0.42096930742263794, "2005": 0.0029254043474793434, "2010": 0.6654226183891296, "2... | 14198646 | Obesity and type 2 diabetes are associated with increased lipogenesis in the liver. This results in fat accumulation in hepatocytes, a condition known as hepatic steatosis, which is a form of nonalcoholic fatty liver disease (NAFLD), the most common cause of liver dysfunction in the United States. Carbohydrate-responsi... | Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. |
{"1011": 0.083342544734478, "1037": 0.030771657824516296, "1056": 0.37974658608436584, "1996": 0.5500838756561279, "1997": 0.026025565341114998, "2003": 0.2983669638633728, "2004": 0.04394211992621422, "2005": 0.02412080205976963, "2008": 0.09050461649894714, "2011": 0.29400965571403503, "2015": 0.34508460760116577, "2... | 14205246 | The spindle apparatus is a microtubule (MT)-based machinery that attaches to and segregates the chromosomes during mitosis and meiosis. Self-organization of the spindle around chromatin involves the assembly of MTs, their attachment to the chromosomes, and their organization into a bipolar array. One regulator of spind... | A Role for NuSAP in Linking Microtubules to Mitotic Chromosomes |
{"2001": 0.1401015669107437, "2003": 0.006812678650021553, "2011": 0.22782009840011597, "2029": 0.052318159490823746, "2034": 0.1510767638683319, "2043": 0.0317181795835495, "2060": 0.3560888469219208, "2061": 1.0526502132415771, "2064": 0.3339579105377197, "2071": 0.058784693479537964, "2075": 0.012615402229130268, "2... | 14225271 | Differentiating somatic cells are progressively restricted to specialized functions during ontogeny, but they can be experimentally directed to form other cell types, including those with complete embryonic potential. Early nuclear reprogramming methods, such as somatic cell nuclear transfer (SCNT) and cell fusion, pos... | Molecular features of cellular reprogramming and development |
{"1044": 0.25239890813827515, "1997": 0.06795065850019455, "2005": 0.1889725625514984, "2024": 0.07884006202220917, "2051": 0.6613984704017639, "2054": 0.13243216276168823, "2064": 0.09495500475168228, "2076": 0.08603433519601822, "2079": 0.49030399322509766, "2109": 0.2976420819759369, "2129": 0.10203468054533005, "21... | 14240343 | Circadian clocks orchestrate 24-h oscillations of essential physiological and behavioral processes in response to daily environmental changes. These clocks are remarkably precise under constant conditions yet highly responsive to resetting signals. With the molecular composition of the core oscillator largely establish... | Small molecule modifiers of circadian clocks |
{"1011": 0.21765978634357452, "1017": 0.7153595685958862, "1047": 0.037378571927547455, "1050": 0.613389253616333, "1052": 0.5483922958374023, "1055": 0.07431721687316895, "1060": 0.3850763738155365, "2003": 0.10379679501056671, "2005": 0.15023678541183472, "2006": 0.21765978634357452, "2011": 0.23710809648036957, "201... | 14241418 | Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 or activating mutations of p110-alpha. These hotspot mutations result in oncogenic activity of the enzyme and contr... | NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. |
{"1017": 0.13670019805431366, "1018": 0.13499516248703003, "1020": 0.347847044467926, "1023": 0.17267228662967682, "1041": 0.16690383851528168, "1043": 0.4770587682723999, "1048": 0.5092619061470032, "1051": 0.7583568692207336, "1052": 0.4041621685028076, "2003": 0.29981520771980286, "2004": 0.2247048318386078, "2007":... | 14252892 | Osteonecrosis is a severe glucocorticoid-induced complication of acute lymphoblastic leukemia treatment. We prospectively screened children (n = 364) with magnetic resonance imaging of hips and knees, regardless of symptoms; the cumulative incidence of any (grade 1-4) versus symptomatic (grade 2-4) osteonecrosis was 71... | Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia. |
{"1014": 0.4374985992908478, "1017": 0.3325583338737488, "1018": 0.29255300760269165, "1020": 0.37707099318504333, "1052": 0.40220460295677185, "1054": 0.5444341897964478, "1998": 0.04767346754670143, "2000": 0.2184450328350067, "2005": 0.306306391954422, "2007": 0.3743882179260254, "2020": 0.11517547070980072, "2021":... | 14260013 | BACKGROUND In the absence of an effective vaccine, HIV continues to spread globally, emphasizing the need for novel strategies to limit its transmission. Pre-exposure prophylaxis (PrEP) with antiretroviral drugs could prove to be an effective intervention strategy if highly efficacious and cost-effective PrEP modalitie... | Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and Tenofovir |
{"1011": 0.20818853378295898, "1017": 0.23402166366577148, "1040": 0.30989447236061096, "1043": 0.38374659419059753, "1997": 0.14518201351165771, "2011": 0.10818854719400406, "2012": 0.06612417846918106, "2015": 0.10818854719400406, "2050": 1.0389231443405151, "2064": 0.3877306580543518, "2071": 0.16110190749168396, "2... | 14275671 | The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested that the resulting correlations among amino acid compositions at different sequence positions can be exploited to infer spatial contacts within the tertiary prot... | Direct-coupling analysis of residue co-evolution captures native contacts across many protein families |
{"1003": 0.06977381557226181, "1014": 0.6233867406845093, "1052": 0.12814582884311676, "2001": 0.06795065850019455, "2005": 0.2852376699447632, "2020": 0.09050461649894714, "2025": 0.1718502640724182, "2051": 0.13925230503082275, "2058": 0.18816383183002472, "2077": 0.029824240133166313, "2087": 0.09228714555501938, "2... | 14290854 | OBJECTIVE To describe variation in antibiotic prescribing for acute cough in contrasting European settings and the impact on recovery. DESIGN Cross sectional observational study with clinicians from 14 primary care research networks in 13 European countries who recorded symptoms on presentation and management. Patients... | Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. |
{"1038": 0.9052929878234863, "1041": 0.17759032547473907, "1052": 0.0606246218085289, "1997": 0.016465263441205025, "2005": 0.13670019805431366, "2011": 0.2231435477733612, "2026": 0.4926934838294983, "2033": 0.5816917419433594, "2035": 0.23556606471538544, "2066": 0.15526613593101501, "2071": 0.20739519596099854, "207... | 14296612 | BACKGROUND Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all tissue types in the body, show great promise as a versatile source of cells for regenerative therapy. However, the basic mechanisms of lineage specification of pluripotent stem cells are largely unknown, and generating suffici... | Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells |
{"1019": 0.8383291959762573, "1044": 0.3519764244556427, "1060": 0.34922540187835693, "1997": 0.01934296265244484, "2013": 0.2711893916130066, "2014": 0.23864774405956268, "2037": 0.2719337046146393, "2049": 0.3005385100841522, "2065": 0.0797421783208847, "2066": 0.4400174915790558, "2071": 0.09761575609445572, "2075":... | 14300799 | A key feature of speech is its stereotypical 5 Hz rhythm. One theory posits that this rhythm evolved through the modification of rhythmic facial movements in ancestral primates. If the hypothesis has any validity, then a comparative approach may shed some light. We tested this idea by using cineradiography (X-ray movie... | Cineradiography of Monkey Lip-Smacking Reveals Putative Precursors of Speech Dynamics |
{"1011": 0.09584271162748337, "1015": 0.6482070088386536, "1018": 0.09228714555501938, "1050": 0.19782574474811554, "1054": 0.12728634476661682, "1998": 0.043007105588912964, "2007": 0.04674193635582924, "2008": 0.07793712615966797, "2011": 0.28743788599967957, "2028": 0.1946154683828354, "2029": 0.2830325961112976, "2... | 14308244 | Neuregulin-1 (NRG1) and its receptor ErbB4 influence several processes of neurodevelopment, but the mechanisms regulating this signalling in the mature brain are not well known. DISC1 is a multifunctional scaffold protein that mediates many cellular processes. Here we present a functional relationship between DISC1 and... | Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. |
{"1009": 0.5893046259880066, "1011": 0.41001203656196594, "1015": 0.41840189695358276, "1016": 0.2247048318386078, "1018": 0.6689305305480957, "1038": 0.4879087805747986, "1039": 0.8255793452262878, "1042": 0.11081436276435852, "1050": 0.5557019114494324, "1056": 0.791648268699646, "1999": 0.07884006202220917, "2006": ... | 14311986 | The molecular basis for the distinctive cytokine expression of CD4+ T helper 1 (Th1) and T helper 2 (Th2) subsets remains elusive. Here, we report that the proto-oncogene c-maf, a basic region/leucine zipper transcription factor, controls tissue-specific expression of IL-4. c-Maf is expressed in Th2 but not Th1 clones ... | The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4 |
{"1011": 0.015504186972975731, "1015": 0.05046287178993225, "1044": 0.4132472574710846, "1045": 0.05786345899105072, "1048": 0.2689530849456787, "1053": 0.8004589080810547, "2002": 0.24018502235412598, "2007": 0.18654440343379974, "2012": 0.2089812457561493, "2029": 0.10993985831737518, "2076": 0.014542185701429844, "2... | 14315749 | In this study, we aimed to investigate changes in the expression of human Clock (hClock), a gene at the core of the circadian gene family, in colorectal carcinomas (CRCs) and to discuss the possible effects. Previous studies have revealed that the disruption of circadian rhythms is one of the endogenous factors that co... | hClock gene expression in human colorectal carcinoma. |
{"1003": 0.05417001247406006, "1014": 0.2223619967699051, "1015": 0.33115679025650024, "1044": 0.2622140049934387, "1050": 0.20739519596099854, "2001": 0.0606246218085289, "2002": 0.3416208028793335, "2034": 0.3949938118457794, "2039": 0.13755162060260773, "2062": 0.06429435312747955, "2073": 0.040196798741817474, "207... | 14319754 | BACKGROUND Highly active antiretroviral therapy (HAART) is being scaled up in developing countries. We compared baseline characteristics and outcomes during the first year of HAART between HIV-1-infected patients in low-income and high-income settings. METHODS 18 HAART programmes in Africa, Asia, and South America (low... | The Antiretroviral Therapy in Lower Income Countries (ART-LINC) Collaboration and ART Cohort Collaboration (ART-CC) groups Summary |
{"1011": 0.46363574266433716, "1017": 0.9209672808647156, "1018": 0.15610189735889435, "1035": 0.3084607720375061, "1047": 0.8893690705299377, "1052": 0.791648268699646, "2011": 0.23479416966438293, "2015": 0.2719337046146393, "2024": 0.03266380727291107, "2029": 0.2576959431171417, "2038": 0.14518201351165771, "2042":... | 14328288 | BACKGROUND Mammalian phosphoinositide 3-kinases (PI 3-kinases) are involved in receptor-mediated signal transduction and have been implicated in processes such as transformation and mitogenesis through their role in elevating cellular phosphatidylinositol (3,4,5)-trisphosphate. Additionally, a PI 3-kinase activity whic... | A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction |
{"1041": 0.5033760666847229, "1042": 0.083342544734478, "1043": 0.4041621685028076, "1055": 0.48430517315864563, "2001": 0.0038986403960734606, "2006": 0.8004589080810547, "2008": 0.006812678650021553, "2011": 0.3916989266872406, "2015": 0.6980181336402893, "2029": 0.14686977863311768, "2058": 0.3897167444229126, "2063... | 14332945 | Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we performed a targeted siRNA screen for genes whose depletion inhibited G1 to S... | Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks |
{"1009": 0.4437839686870575, "1011": 0.09672962874174118, "1019": 0.05970508232712746, "1023": 0.46853771805763245, "1039": 0.6016870141029358, "1043": 0.21922965347766876, "1050": 0.35745587944984436, "1052": 0.6212902665138245, "1996": 0.41389304399490356, "1999": 0.09050461649894714, "2004": 0.1221139207482338, "200... | 14333540 | Neural crest (NC) cells arise in the dorsal neural tube (NT) and migrate into the embryo to develop into many different cell types. A major unresolved question is when and how the fate of NC cells is decided. There is widespread evidence for multipotential NC cells, whose fates are decided during or after migration. Th... | Neural crest cell lineage segregation in the mouse neural tube. |
{"1000": 0.08154398202896118, "1998": 0.13243216276168823, "2000": 0.036437395960092545, "2013": 0.34715715050697327, "2033": 0.5562619566917419, "2035": 0.37102460861206055, "2041": 0.18167030811309814, "2042": 0.3381449282169342, "2047": 0.07431721687316895, "2054": 0.09761575609445572, "2058": 0.007782140281051397, ... | 14337960 | Decisions to eliminate malaria from all or part of a country involve a complex set of factors, and this complexity is compounded by ambiguity surrounding some of the key terminology, most notably "control" and "elimination. " It is impossible to forecast resource and operational requirements accurately if endpoints hav... | How absolute is zero? An evaluation of historical and current definitions of malaria elimination |
{"1011": 0.5151132941246033, "1017": 0.129004567861557, "1037": 0.6704301834106445, "1039": 0.12384103983640671, "1044": 0.2954642176628113, "1996": 0.07341018319129944, "2002": 0.7276995778083801, "2004": 0.083342544734478, "2005": 0.18167030811309814, "2007": 0.41065993905067444, "2008": 0.14602625370025635, "2010": ... | 14338915 | The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A localization at centromeres and form a complex that is conserved from fission yeast to human. Fission yeast sim1 mutants that alleviate kinetochore domain silencing are defective in Scm... | Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin |
{"1011": 0.01934296265244484, "1043": 0.6451379656791687, "1044": 0.43244171142578125, "1051": 0.9886114001274109, "1056": 0.7389566898345947, "2003": 0.3903779089450836, "2005": 0.083342544734478, "2011": 0.1718502640724182, "2012": 0.15359249711036682, "2013": 0.13670019805431366, "2031": 0.06429435312747955, "2046":... | 14340571 | Background Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and a range of clinical manifestations. It is caused by an inappropriate immune response to dietary gluten and is treated with a gluten-free diet. Recent feeding studies have indicated oats to be ... | The Molecular Basis for Oat Intolerance in Patients with Celiac Disease |
{"1014": 0.5685047507286072, "1038": 0.0317181795835495, "1045": 0.2837681770324707, "1051": 0.472198486328125, "1052": 0.6950984001159668, "1059": 0.5244048833847046, "1998": 0.026025565341114998, "1999": 0.34300774335861206, "2007": 0.36967599391937256, "2026": 0.5551415085792542, "2048": 0.026025565341114998, "2050"... | 14361849 | IntroductionWe conducted the present study to investigate the potential beneficial and adverse effects of continuous positive airway pressure (CPAP) compared with bi-level positive airway pressure (BiPAP) noninvasive ventilation in patients with cardiogenic pulmonary oedema. MethodWe included randomized controlled stud... | A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis |
{"1011": 0.11081436276435852, "1040": 0.11865071207284927, "1049": 0.22859740257263184, "1055": 0.16359257698059082, "1156": 0.7500885725021362, "2003": 0.052318159490823746, "2007": 0.036437395960092545, "2011": 0.27934664487838745, "2012": 0.18411032855510712, "2026": 0.4831010699272156, "2029": 0.14433705806732178, ... | 14362678 | Mitochondrial permeability transition pore (mPTP) is involved in cardiac dysfunction during chronic β-adrenergic receptor (β-AR) stimulation. The mechanism by which chronic β-AR stimulation leads to mPTP openings is elusive. Here, we show that chronic administration of isoproterenol (ISO) persistently increases the fre... | CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation |
{"1011": 0.2493593990802765, "1049": 0.05694137513637543, "1999": 0.07793712615966797, "2004": 0.07159364968538284, "2005": 0.11604541540145874, "2015": 0.3353555500507355, "2020": 0.06337817758321762, "2021": 0.7925328612327576, "2029": 0.0009760859538801014, "2076": 0.5495203733444214, "2078": 0.46853771805763245, "2... | 14362780 | The role of microRNAs (miRNAs) in infectious diseases is becoming more and more apparent, and the use of miRNAs as a diagnostic tool and their therapeutic application has become the major focus of investigation. The aim of this study was to identify miRNAs involved in the immune signaling of macrophages in response to ... | MicroRNA Response of Primary Human Macrophages to Arcobacter Butzleri Infection |
{"1011": 0.009718249551951885, "1016": 0.7592713832855225, "1039": 0.06520967930555344, "1044": 0.30989447236061096, "1052": 0.4950772523880005, "1057": 0.22548456490039825, "2003": 0.22157983481884003, "2008": 0.06429435312747955, "2011": 0.27934664487838745, "2012": 0.09584271162748337, "2029": 0.25239890813827515, "... | 14367469 | Human Period 2 (hPer2) is a transcriptional regulator at the core of the circadian clock mechanism that is responsible for generating the negative feedback loop that sustains the clock. Its relevance to human disease is underlined by alterations in its function that affect numerous biochemical and physiological process... | The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells |
{"1017": 0.16607704758644104, "1019": 0.0058422754518687725, "1039": 0.32058215141296387, "1044": 0.1718502640724182, "1047": 0.9531047344207764, "1997": 0.1873544454574585, "1999": 0.09228714555501938, "2003": 0.129004567861557, "2008": 0.0752234235405922, "2011": 0.13499516248703003, "2024": 0.2969166338443756, "2029... | 14376683 | The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of circular double-stranded DNA. We have characterized the viral transcript and determined the complete sequence of the genome of Commelina mellow mottle virus (CoYMV), a member of this group. Analysis of th... | Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus. |
{"1011": 0.14686977863311768, "1015": 0.20739519596099854, "1022": 0.7067264318466187, "1039": 0.036437395960092545, "1043": 0.8109301924705505, "1050": 0.6989894509315491, "1061": 0.3656192123889923, "1062": 0.8408597707748413, "1999": 0.11778303235769272, "2002": 0.43244171142578125, "2005": 0.10291612148284912, "200... | 14380875 | Glucocorticoids repress NFkappaB-mediated activation of proinflammatory genes such as interleukin-8 (IL-8) and ICAM-1. Our experiments suggest that the glucocorticoid receptor (GR) confers this effect by associating through protein-protein interactions with NFkappaB bound at each of these genes. That is, we show that t... | The Glucocorticoid Receptor Inhibits |
{"1009": 0.14518201351165771, "1011": 0.2034190446138382, "1039": 0.27934664487838745, "1052": 0.417115718126297, "1056": 0.47827014327049255, "1057": 0.3070250153541565, "1998": 0.17020416259765625, "2006": 0.018384648486971855, "2007": 0.32764431834220886, "2011": 0.31489628553390503, "2015": 0.1064341589808464, "202... | 14386505 | Myeloid cells play pivotal roles in chronic inflammatory diseases through their broad proinflammatory, destructive, and remodeling capacities. CD200 is widely expressed on a variety of cell types, while the recently identified CD200R is expressed on myeloid cells and T cells. CD200 deletion in vivo results in myeloid c... | Regulation of myeloid cell function through the CD200 receptor. |
{"1003": 0.1332872211933136, "1011": 0.004870930220931768, "1039": 0.9100211262702942, "1044": 0.5662899017333984, "1050": 0.07612881064414978, "1058": 0.20977331697940826, "1998": 0.21530038118362427, "2001": 0.07431721687316895, "2002": 1.1450434923171997, "2007": 0.5116065740585327, "2010": 0.4067663550376892, "2020... | 14390137 | OBJECTIVE Rates of hepatitis C (HCV) infection, testing, and treatment were compared among patients with schizophrenia, a substance use disorder, or co-occurring schizophrenia or schizoaffective disorder and a substance use disorder and a control group. METHODS Information about 293,445 patients of the Northwest Vetera... | Management of hepatitis C disease among VA patients with schizophrenia and substance use disorders. |
{"1003": 0.0913962796330452, "1009": 0.5795059204101562, "1014": 0.2493593990802765, "1041": 0.06795065850019455, "1997": 0.08782484382390976, "1999": 0.28597161173820496, "2000": 0.15860503911972046, "2007": 0.4879087805747986, "2011": 0.1212492436170578, "2013": 0.09317722171545029, "2020": 0.04767346754670143, "2038... | 14395738 | Studies from sub-Saharan Africa indicate that children made vulnerable by poverty have been disproportionately affected by HIV with many exposed via mother-to-child transmission. For youth living with HIV, adherence to life-saving treatment regimens are likely to be affected by the complex set of economic and social ci... | Equity in adherence to antiretroviral therapy among economically vulnerable adolescents living with HIV in Uganda |
{"1043": 0.12556517124176025, "2005": 0.1693800985813141, "2011": 0.011650617234408855, "2026": 0.7408206462860107, "2047": 0.1905880719423294, "2057": 0.10379679501056671, "2064": 0.13755162060260773, "2071": 0.015504186972975731, "2076": 0.21687394380569458, "2079": 0.05417001247406006, "2097": 0.0752234235405922, "2... | 14402338 | The pathways that comprise cellular metabolism are highly interconnected, and alterations in individual enzymes can have far-reaching effects. As a result, global profiling methods that measure gene expression are of limited value in predicting how the loss of an individual function will affect the cell. In this work, ... | High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism |
{"1011": 0.19622190296649933, "1017": 0.5662899017333984, "1039": 0.35128939151763916, "1043": 0.9739698171615601, "1061": 0.755608320236206, "2003": 0.1212492436170578, "2011": 0.3381449282169342, "2012": 0.10906458646059036, "2015": 0.05046287178993225, "2029": 0.17759032547473907, "2050": 0.7710843086242676, "2079":... | 14405193 | Selective control of receptor trafficking provides a mechanism for remodeling the receptor composition of excitatory synapses, and thus supports synaptic transmission, plasticity, and development. GluN3A (formerly NR3A) is a nonconventional member of the NMDA receptor (NMDAR) subunit family, which endows NMDAR channels... | Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors. |
{"1009": 0.39762192964553833, "1011": 0.13071982562541962, "1016": 0.1229778528213501, "1047": 0.9131608605384827, "1999": 0.11951763927936554, "2000": 0.1401015669107437, "2004": 0.5398913025856018, "2007": 0.3519764244556427, "2011": 0.09050461649894714, "2012": 0.6233867406845093, "2026": 1.0087559223175049, "2029":... | 14407673 | RATIONALE Hemizygous deficiency of the transcription factor Krüppel-like factor 2 (KLF2) has been shown previously to augment atherosclerosis in hypercholesterolemic mice. However, the cell type responsible for the increased atherosclerosis due to KLF2 deficiency has not been identified. This study examined the consequ... | Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis. |
{"1003": 0.11604541540145874, "1014": 0.5540198087692261, "1019": 0.06612417846918106, "1023": 0.19220098853111267, "1052": 0.2881702482700348, "1055": 0.43053874373435974, "1177": 0.4190443754196167, "2001": 0.13157635927200317, "2004": 0.12470348179340363, "2020": 0.021256839856505394, "2034": 0.27564704418182373, "2... | 14408200 | CONTEXT Rates of hospital-onset methicillin-resistant Staphylococcus aureus (MRSA) infections are reported as decreasing, but recent rates of community-onset S. aureus infections are less known. OBJECTIVES To characterize the overall and annual incidence rates of community-onset and hospital-onset S. aureus bacteremia ... | Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010. |
{"1011": 0.18167030811309814, "1017": 0.31132611632347107, "1040": 0.4879087805747986, "1050": 0.6970458030700684, "1051": 0.22548456490039825, "1999": 0.015504186972975731, "2004": 0.6989894509315491, "2011": 0.23556606471538544, "2012": 0.25239890813827515, "2029": 0.32764431834220886, "2050": 0.15526613593101501, "2... | 14419116 | Whole cell patch-clamp recordings were made from sympathetic preganglionic neurons (SPNs) in the intermediolateral cell column of thoracolumbar spinal cord slices of 12- to 16-day-old rats, and the effects of pituitary adenylate cyclase activating polypeptide (PACAP)-38 on N-methyl-D-aspartate (NMDA)- and kainate (KA)-... | Potentiation of NMDA currents by pituitary adenylate cyclase activating polypeptide in neonatal rat sympathetic preganglionic neurons. |
{"1015": 0.4349733293056488, "1017": 0.1221139207482338, "1040": 0.401551216840744, "1054": 0.2447827309370041, "2004": 0.5784112811088562, "2007": 0.026976587250828743, "2028": 0.14518201351165771, "2029": 0.13243216276168823, "2054": 0.10818854719400406, "2078": 0.75193190574646, "2087": 0.3177432417869568, "2093": 0... | 14434123 | AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, neurofibrillary tangle formation, and neuronal loss. Growing evidences indicate that dysregulation of regulator... | Aberrant Expression of RCAN1 in Alzheimer’s Pathogenesis: A New Molecular Mechanism and a Novel Drug Target |
{"1016": 0.013579257763922215, "1020": 0.23556606471538544, "1041": 0.06795065850019455, "1997": 0.04394211992621422, "1998": 0.04953393340110779, "2012": 0.1994270235300064, "2032": 0.026976587250828743, "2051": 0.4196864068508148, "2056": 0.04394211992621422, "2057": 0.015504186972975731, "2064": 0.2184450328350067, ... | 14437255 | UNLABELLED Congruent audiovisual speech enhances our ability to comprehend a speaker, even in noise-free conditions. When incongruent auditory and visual information is presented concurrently, it can hinder a listener's perception and even cause him or her to perceive information that was not presented in either modali... | Congruent Visual Speech Enhances Cortical Entrainment to Continuous Auditory Speech in Noise-Free Conditions. |
{"1011": 0.06886265426874161, "1018": 0.27712854743003845, "1022": 0.6907027959823608, "1048": 0.08782484382390976, "1996": 0.31132611632347107, "1997": 0.1718502640724182, "1999": 0.17267228662967682, "2005": 0.22548456490039825, "2011": 0.3325583338737488, "2012": 0.13157635927200317, "2029": 0.2763880789279938, "203... | 14446279 | In the yeast Saccharomyces cerevisiae that lacks lamins, the nuclear pore complex (NPC) has been proposed to serve a role in chromatin organization. Here, using fluorescence microscopy in living cells, we show that nuclear pore proteins of the Nup84 core complex, Nup84p, Nup145Cp, Nup120p, and Nup133p, serve to anchor ... | Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region |
{"1017": 0.2659635543823242, "1020": 0.45932671427726746, "1052": 0.969535231590271, "1996": 0.04113444685935974, "2004": 0.03831886500120163, "2008": 0.02887592278420925, "2011": 0.24631060659885406, "2029": 0.3526630103588104, "2076": 0.0009760859538801014, "2079": 0.1685553640127182, "2092": 0.16110190749168396, "21... | 14460402 | The molecular mechanisms that regulate adult neural precursor cell (NPC) survival, and thus maintain adult neurogenesis, are not well defined. Here, we investigate the role of p63, a p53 family member, in adult NPC function in mice. Conditional ablation of p63 in adult NPCs or p63 haploinsufficiency led to reduced numb... | p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior. |
{"1009": 0.5729197263717651, "1011": 0.2763880789279938, "1015": 0.4093637466430664, "1043": 0.854249119758606, "1052": 0.7067264318466187, "1054": 0.5784112811088562, "1056": 0.8731874823570251, "1998": 0.19782574474811554, "2007": 0.21372433006763458, "2011": 0.08782484382390976, "2028": 0.16524957120418549, "2029": ... | 14461101 | Certain bacterial adhesins appear to promote a pathogen's extracellular lifestyle rather than its entry into host cells. However, little is known about the stimuli elicited upon such pathogen host-cell interactions. Here, we report that type IV pili (Tfp)-producing Neisseria gonorrhoeae (P(+)GC) induces an immediate re... | Tyrosine-Phosphorylated Caveolin-1 Blocks Bacterial Uptake by Inducing Vav2-RhoA-Mediated Cytoskeletal Rearrangements |
{"1011": 0.2576959431171417, "1039": 0.14349138736724854, "1043": 1.1870332956314087, "2011": 0.020300358533859253, "2015": 0.9240728616714478, "2021": 0.016465263441205025, "2029": 0.07431721687316895, "2038": 0.19220098853111267, "2064": 0.04487626627087593, "2071": 0.0058422754518687725, "2075": 0.055094651877880096... | 14464451 | Next-generation-sequencing (NGS) has revolutionized the field of genome assembly because of its much higher data throughput and much lower cost compared with traditional Sanger sequencing. However, NGS poses new computational challenges to de novo genome assembly. Among the challenges, GC bias in NGS data is known to a... | Effects of GC Bias in Next-Generation-Sequencing Data on De Novo Genome Assembly |
{"1014": 0.045809537172317505, "1045": 0.4734157919883728, "1050": 0.0317181795835495, "1052": 0.5941681861877441, "1062": 0.7836518287658691, "2007": 0.11951763927936554, "2011": 0.10379679501056671, "2012": 0.014542185701429844, "2020": 0.020300358533859253, "2029": 0.09938567131757736, "2039": 0.12556517124176025, "... | 14471161 | Circadian disruption accelerates cancer progression, whereas circadian reinforcement could halt it. Mice with P03 pancreatic adenocarcinoma (n = 77) were synchronized and fed ad libitum (AL) or with meal timing (MT) from Zeitgeber time (ZT) 2 to ZT6 with normal or fat diet. Tumor gene expression profiling was determine... | Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing. |
{"1011": 0.09761575609445572, "1014": 0.14602625370025635, "1018": 0.22704219818115234, "1019": 0.5301685929298401, "1020": 0.5551415085792542, "1022": 0.1913948506116867, "1026": 0.011650617234408855, "1045": 0.16524957120418549, "1049": 0.38308101892471313, "1051": 0.3241194784641266, "1052": 0.6197150945663452, "115... | 14474178 | The objective of the present study was to determine if chicken melanoma-differentiation-associated gene 5 (MDA5) senses infectious bursal disease virus infection to induce innate immunity that bridges to adaptive immunity. During IBDV infection in HD11 cells, IBDV titers and RNA loads increased up to 3.4 × 107 plaque-f... | Role of chicken melanoma differentiation-associated gene 5 in induction and activation of innate and adaptive immune responses to infectious bursal disease virus in cultured macrophages |
{"1022": 0.2409527748823166, "1023": 0.2852376699447632, "1040": 0.23864774405956268, "1044": 0.11430477350950241, "1999": 0.04113444685935974, "2006": 0.08244366943836212, "2007": 0.3374483287334442, "2013": 0.016465263441205025, "2026": 0.6170841455459595, "2033": 0.13499516248703003, "2042": 0.045809537172317505, "2... | 14475235 | Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.), trinucleotide expansion associated diseases (myotonic dystrophy, Huntington's, etc.) and even some forms of cancer have increased inci... | Age-Associated Sperm DNA Methylation Alterations: Possible Implications in Offspring Disease Susceptibility |
{"1015": 0.06337817758321762, "1043": 0.11081436276435852, "1047": 0.5968599319458008, "1050": 0.07159364968538284, "1060": 0.6911921501159668, "2002": 0.034552380442619324, "2003": 0.37640097737312317, "2007": 0.15526613593101501, "2050": 0.14095009863376617, "2064": 0.12814582884311676, "2072": 0.15442965924739838, "... | 14479433 | Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis. Mutations in several different genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account for all familial cases. Here we report four individuals from two unrelated families with neonatal chol... | Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis |
{"1016": 0.3870677351951599, "1043": 0.6233867406845093, "1044": 0.304147332906723, "1052": 0.7191727757453918, "2003": 0.2741633653640747, "2004": 0.021256839856505394, "2005": 0.27044451236724854, "2007": 0.4734157919883728, "2010": 0.8143964409828186, "2022": 0.9348671436309814, "2029": 0.06795065850019455, "2051": ... | 14482051 | BACKGROUND Panobinostat is a histone deacetylase inhibitor with antineoplastic and antiangiogenic effects in glioma that may work synergistically with bevacizumab. We conducted a multicenter phase II trial of panobinostat combined with bevacizumab in patients with recurrent high-grade glioma (HGG). METHODS Patients wit... | Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma. |
{"1009": 0.5512100458145142, "1011": 0.06246116757392883, "1015": 0.052318159490823746, "1017": 0.10291612148284912, "1039": 0.8433839678764343, "1048": 0.022212404757738113, "1052": 0.25845035910606384, "1997": 0.00875066313892603, "2003": 0.25845035910606384, "2005": 0.06429435312747955, "2007": 0.013579257763922215,... | 14492339 | Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited ... | Blood monocytes consist of two principal subsets with distinct migratory properties |
{"1018": 0.08692999184131622, "1038": 0.9209672808647156, "1996": 0.3134697377681732, "2008": 0.08064348995685577, "2011": 0.5410289764404297, "2012": 0.1221139207482338, "2013": 0.12728634476661682, "2029": 0.2409527748823166, "2033": 0.7436100244522095, "2053": 0.9302552938461304, "2064": 0.2637155055999756, "2076": ... | 14492964 | Signals released by the Spemann organizer of the amphibian gastrula can directly induce neural tissue from ectoderm and can dorsalize ventral mesoderm to form muscle. The secreted polypeptide noggin mimics these activities and is expressed at the appropriate time and place to participate in the organizer signal. Neural... | The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 |
{"1011": 0.0009760859538801014, "1015": 0.2447827309370041, "1039": 0.01934296265244484, "1047": 0.21765978634357452, "1056": 0.2317005842924118, "2008": 0.02792670577764511, "2011": 0.11517547070980072, "2029": 0.22626367211341858, "2058": 0.39367714524269104, "2076": 0.11256109178066254, "2079": 0.15526613593101501, ... | 14496749 | Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcr... | A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span |
{"1003": 0.09317722171545029, "1050": 0.3723714053630829, "1057": 0.2231435477733612, "2000": 0.23710809648036957, "2001": 0.0842406153678894, "2011": 0.040196798741817474, "2013": 0.5495203733444214, "2020": 0.3683255612850189, "2040": 0.4093637466430664, "2042": 0.3141832649707794, "2043": 0.12728634476661682, "2050"... | 14500725 | BACKGROUND The large-scale emigration of physicians from sub-Saharan Africa (SSA) to high-income nations is a serious development concern. Our objective was to determine current emigration trends of SSA physicians found in the physician workforce of the United States. METHODS AND FINDINGS We analyzed physician data fro... | Physician Emigration from Sub-Saharan Africa to the United States: Analysis of the 2011 AMA Physician Masterfile |
{"1011": 0.056018441915512085, "1039": 0.6654226183891296, "1041": 0.15610189735889435, "1047": 0.5174443125724792, "1061": 0.6118015646934509, "1996": 0.11081436276435852, "1997": 0.01934296265244484, "1999": 0.2018241584300995, "2004": 0.08154398202896118, "2005": 0.04674193635582924, "2011": 0.26296505331993103, "20... | 14501880 | The kynurenine pathway of tryptophan metabolism is involved in the pathogenesis of several brain diseases, but its physiological functions remain unclear. We report that kynurenic acid, a metabolite in this pathway, functions as a regulator of food-dependent behavioral plasticity in C. elegans. The experience of fastin... | Kynurenic Acid Is a Nutritional Cue that Enables Behavioral Plasticity |
{"1011": 0.18654440343379974, "1039": 0.4568560719490051, "1042": 0.28670501708984375, "1999": 0.02316705882549286, "2003": 0.39367714524269104, "2008": 0.026976587250828743, "2011": 0.29619070887565613, "2015": 0.3034266233444214, "2024": 0.4374985992908478, "2076": 0.13755162060260773, "2079": 0.4444103240966797, "20... | 14530534 | Chromatin insulators are DNA elements that regulate the level of gene expression either by preventing gene silencing through the maintenance of heterochromatin boundaries or by preventing gene activation by blocking interactions between enhancers and promoters. CCCTC-binding factor (CTCF), a ubiquitously expressed 11-z... | Comprehensive Identification and Annotation of Cell Type-Specific and Ubiquitous CTCF-Binding Sites in the Human Genome |
{"1043": 0.9470623731613159, "1059": 0.1994270235300064, "1998": 0.29328158497810364, "2019": 0.4556184411048889, "2033": 0.5696102976799011, "2078": 0.8682814836502075, "2080": 0.3683255612850189, "2083": 0.41065993905067444, "2090": 0.38441169261932373, "2092": 0.4938860833644867, "2108": 0.06703783571720123, "2110":... | 14535322 | Recent experimental studies and theoretical models have begun to address the challenge of establishing a causal link between subjective conscious experience and measurable neuronal activity. The present review focuses on the well-delimited issue of how an external or internal piece of information goes beyond nonconscio... | Experimental and Theoretical Approaches to Conscious Processing |
{"1011": 0.22626367211341858, "1015": 0.24631060659885406, "1018": 0.004870930220931768, "1047": 0.4177590310573578, "1055": 0.7827593088150024, "2003": 0.21214580535888672, "2008": 0.05786345899105072, "2028": 0.02412080205976963, "2029": 0.23402166366577148, "2064": 0.07159364968538284, "2078": 0.8925741910934448, "2... | 14541844 | Highly conserved among eukaryotic cells, the AMP-activated kinase (AMPK) is a central regulator of carbon metabolism. To map the complete network of interactions around AMPK in yeast (Snf1) and to evaluate the role of its regulatory subunit Snf4, we measured global mRNA, protein and metabolite levels in wild type, Delt... | Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator |
{"1011": 0.3127557039260864, "1016": 0.37371641397476196, "1040": 0.35950297117233276, "1042": 0.14179791510105133, "2011": 0.22157983481884003, "2029": 0.1485546976327896, "2030": 0.12470348179340363, "2048": 0.06246116757392883, "2066": 0.4531385898590088, "2072": 0.15275461971759796, "2076": 0.12384103983640671, "20... | 14544564 | Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormones known as dafachronic acids (DAs) influence longevity by binding to and regulating the activity of the conserved n... | Influence of Steroid Hormone Signaling on Life Span Control by Caenorhabditis elegans Insulin-Like Signaling |
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