spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1039": 0.02887592278420925, "1044": 0.4500300884246826, "1999": 0.083342544734478, "2002": 0.4286321699619293, "2004": 0.02412080205976963, "2013": 0.567397952079773, "2020": 0.08961215615272522, "2024": 0.19782574474811554, "2029": 0.10993985831737518, "2043": 0.10906458646059036, "2073": 0.04113444685935974, "2076"... | 14550841 | Hematopoietic stem cells (HSCs) in adult marrow are believed to be derived from fetal liver precursors. To study cell kinetics involved in long-term hematopoiesis, we studied single-sorted candidate HSCs from fetal liver that were cultured in the presence of a mixture of stimulatory cytokines. After 8–10 d, the number ... | Asymmetric Cell Divisions Sustain Long-Term Hematopoiesis from Single-sorted Human Fetal Liver Cells |
{"1011": 0.06977381557226181, "1017": 0.29981520771980286, "1044": 0.48670899868011475, "2010": 0.822151780128479, "2012": 0.0752234235405922, "2029": 0.18492233753204346, "2033": 0.4974553883075714, "2034": 0.39367714524269104, "2043": 0.23864774405956268, "2044": 0.20739519596099854, "2061": 0.969535231590271, "2067"... | 14555750 | Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem cell (iPSC) state, many mechanistic questions still remain. To gain insight into the earliest events in the reprogramming process, we systematically analyzed the transcriptional and epigene... | Reprogramming factor expression initiates widespread targeted chromatin remodeling. |
{"1998": 0.4356052577495575, "2007": 0.28963330388069153, "2021": 0.04394211992621422, "2031": 0.015504186972975731, "2064": 0.2516399025917053, "2066": 0.20739519596099854, "2071": 0.004870930220931768, "2076": 0.2231435477733612, "2089": 0.2447827309370041, "2090": 0.006812678650021553, "2132": 0.2837681770324707, "2... | 14566771 | The relationship of migraine and stroke is complex. Stroke may be coincidental with migraine but migraine may confer an increased risk of stroke in women under 45 years of age and possibly in men who have migraine with aura. Stroke may mimic migraine but migraine syndromes may be symptomatic of underlying cerebrovascul... | Stroke and migraine--the spectrum of cause and effect. |
{"1011": 0.1994270235300064, "1015": 0.14518201351165771, "1020": 0.09761575609445572, "1021": 0.41840189695358276, "1022": 0.3177432417869568, "1052": 0.10906458646059036, "1060": 0.2478361576795578, "1996": 0.16607704758644104, "2008": 0.176772341132164, "2011": 0.31845372915267944, "2029": 0.33675122261047363, "2030... | 14581009 | The Polycomb Group (PcG) of chromatin modifiers regulates pluripotency and differentiation. Mammalian genomes encode multiple homologs of the Polycomb repressive complex 1 (PRC1) components, including five orthologs of the Drosophila Polycomb protein (Cbx2, Cbx4, Cbx6, Cbx7, and Cbx8). We have identified Cbx7 as the pr... | MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation |
{"1011": 0.26446542143821716, "1044": 0.7942996621131897, "1996": 0.15275461971759796, "1998": 0.38574060797691345, "1999": 0.040196798741817474, "2004": 0.0019512200960889459, "2005": 0.29036402702331543, "2007": 0.12470348179340363, "2015": 0.06337817758321762, "2019": 0.10993985831737518, "2021": 0.01454218570142984... | 14584755 | The renin-angiotensin-aldosterone system plays a major role in the pathophysiology of hypertension and closely related cardio- and cerebrovascular events. Although both angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor antagonists (angiotensin receptor blockers; ARBs) are equally important in the ... | Differences in the Clinical Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: A Critical Review of the Evidence |
{"1011": 0.46055975556373596, "1015": 0.6139179468154907, "1048": 0.9886114001274109, "1056": 0.7898768186569214, "1996": 0.016465263441205025, "1997": 0.04113444685935974, "2006": 0.3662964701652527, "2008": 0.045809537172317505, "2011": 0.2493593990802765, "2028": 0.22937409579753876, "2029": 0.22548456490039825, "20... | 14591894 | Cells such as fibroblasts and endothelial cells migrate through the coordinated responses of discrete integrin-containing focal adhesions and complexes. In contrast, little is known about the organization of integrins on the highly motile T lymphocyte. We have investigated the distribution, activity, and cytoskeletal l... | A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes |
{"1014": 0.176772341132164, "1052": 0.26146242022514343, "1056": 0.14095009863376617, "1062": 0.08244366943836212, "1156": 0.5364705324172974, "1998": 0.2089812457561493, "2004": 0.02887592278420925, "2005": 0.29981520771980286, "2007": 0.08244366943836212, "2029": 0.11430477350950241, "2051": 0.2881702482700348, "2058... | 14606752 | OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. DESIGN Meta-analysis. DATA SOURCES Medline, Embase, the Cochrane Trials Registry, and PsycLIT. Studies reviewed Randomised trials of adults receiving tricyclics a... | Tricyclic antidepressants and headaches: systematic review and meta-analysis |
{"1039": 0.5789587497711182, "2003": 0.03266380727291107, "2008": 0.08513788133859634, "2010": 0.5483922958374023, "2011": 0.1930064558982849, "2012": 0.3269403576850891, "2015": 0.10731173306703568, "2029": 0.32270604372024536, "2046": 0.2539152204990387, "2064": 0.2409527748823166, "2073": 0.3019835948944092, "2075":... | 14610165 | Antisense transcription is widespread in many genomes; however, how much is functional is hotly debated. We are investigating functionality of a set of long noncoding antisense transcripts, collectively called COOLAIR, produced at Arabidopsis FLOWERING LOCUS C (FLC). COOLAIR initiates just downstream of the major sense... | Functional Consequences of Splicing of the Antisense Transcript COOLAIR on FLC Transcription |
{"1011": 0.14518201351165771, "1020": 0.1332872211933136, "1039": 0.3409265875816345, "1041": 0.6107416749000549, "1047": 0.11081436276435852, "1050": 0.9739698171615601, "1052": 0.03360854089260101, "1155": 0.5979346632957458, "1164": 0.8517522215843201, "1999": 0.07612881064414978, "2007": 0.24631060659885406, "2029"... | 14615911 | We developed a novel mouse model of malignant pleural effusion (MPE) by injecting Lewis lung cancer (LLC) cells directly into the pleural space of syngeneic C57B/6 mice. The pleural effusions in this model share common cellular and biochemical features with human MPEs. Implantation and growth of pleural tumors triggers... | Nuclear Factor-�B Affects Tumor Progression in a Mouse Model of Malignant Pleural Effusion |
{"1009": 0.3956514894962311, "1015": 0.1477125883102417, "1017": 0.1930064558982849, "1018": 0.053244512528181076, "1040": 0.14602625370025635, "1043": 0.2822965085506439, "1045": 0.12642613053321838, "1052": 0.8658194541931152, "1062": 0.00875066313892603, "1609": 0.4132472574710846, "2000": 0.3070250153541565, "2001"... | 14626540 | PURPOSE To estimate the maximum tolerated dose (MTD) of single-agent PF-04449913, and to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity in patients with advanced tumors. EXPERIMENTAL DESIGN A 3+3 design was used in this open-label, multicenter, phase I study and do... | A phase I study of PF-04449913, an oral hedgehog inhibitor, in patients with advanced solid tumors. |
{"1041": 0.7105726003646851, "1044": 0.23479416966438293, "1057": 0.7426811456680298, "2002": 0.3910386264324188, "2004": 0.3070250153541565, "2005": 0.05139094591140747, "2006": 0.009718249551951885, "2007": 0.12728634476661682, "2010": 1.3660717010498047, "2011": 0.29255300760269165, "2029": 0.1685553640127182, "2037... | 14637235 | Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stops. Although chromosomal histones are stable, excess (non-chromatin bound) histones are rap... | Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis |
{"1011": 0.06520967930555344, "1022": 0.3170322775840759, "1038": 0.7764897346496582, "1048": 0.22937409579753876, "1056": 1.0920805931091309, "2005": 0.10555581003427505, "2006": 0.2531573474407196, "2008": 0.040196798741817474, "2011": 0.2881702482700348, "2026": 0.7647408246994019, "2029": 0.28450319170951843, "2063... | 14644164 | TLR sense microbial infections, and control activation of immune responses. Dendritic cells, macrophages, and B lymphocytes express TLR and the TLR-signaling adaptor protein MyD88. The impact of TLR-activated B cells on T cell-mediated inflammation is unknown. In this study, we have used mice carrying B cell-restricted... | TLR-activated B cells suppress T cell-mediated autoimmunity. |
{"1009": 0.3995884954929352, "1011": 0.1930064558982849, "1056": 0.8550800085067749, "2000": 0.1970241367816925, "2002": 0.1332872211933136, "2005": 0.31560876965522766, "2007": 0.0797421783208847, "2013": 0.14349138736724854, "2029": 0.07431721687316895, "2034": 0.08154398202896118, "2064": 0.09406650811433792, "2085"... | 14647747 | Strategies to prevent organ transplant rejection whilst minimizing long-term immunosuppression are currently under intense investigation with regulatory T cells (Tregs) nearing clinical application. The clinical trial, ThRIL, recently commenced at King's College London, proposes to use Treg cell therapy to induce toler... | Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation |
{"1011": 0.13071982562541962, "1017": 0.32764431834220886, "1018": 0.04207121208310127, "2013": 0.14433705806732178, "2015": 0.1401015669107437, "2029": 0.08064348995685577, "2035": 0.07431721687316895, "2043": 0.0606246218085289, "2048": 0.09406650811433792, "2053": 0.03266380727291107, "2057": 0.056018441915512085, "... | 14652521 | The prediction of novel pre-microRNA (miRNA) from genomic sequence has received considerable attention recently. However, the majority of studies have focused on the human genome. Previous studies have demonstrated that sensitivity (correctly detecting true miRNA) is sustained when human-trained methods are applied to ... | A framework for improving microRNA prediction in non-human genomes |
{"1009": 0.36967599391937256, "1011": 0.13157635927200317, "1017": 0.09050461649894714, "1022": 0.8272887468338013, "1039": 0.020300358533859253, "1040": 0.06886265426874161, "1048": 0.8349450826644897, "1052": 0.29036402702331543, "1056": 0.762009859085083, "2007": 0.1477125883102417, "2011": 0.15023678541183472, "202... | 14657344 | Leishmania mexicana (Lm) causes localized (LCL) and diffuse (DCL) cutaneous leishmaniasis. DCL patients have a poor cellular immune response leading to chronicity. It has been proposed that CD8 T lymphocytes (CD8) play a crucial role in infection clearance, although the role of CD8 cytotoxicity in disease control has n... | CD8 Cells of Patients with Diffuse Cutaneous Leishmaniasis Display Functional Exhaustion: The Latter Is Reversed, In Vitro, by TLR2 Agonists |
{"1017": 0.08782484382390976, "1020": 0.05694137513637543, "1044": 0.4126010537147522, "1997": 0.083342544734478, "2002": 0.19220098853111267, "2003": 0.06246116757392883, "2013": 0.41195443272590637, "2029": 0.14939609169960022, "2038": 0.0913962796330452, "2064": 0.05417001247406006, "2073": 0.21293537318706512, "208... | 14658685 | The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling genomic e... | Enhancer Evolution across 20 Mammalian Species |
{"1011": 0.26296505331993103, "1013": 0.17020416259765625, "1015": 0.5438674688339233, "1016": 0.5347557663917542, "1039": 0.056018441915512085, "1043": 0.1477125883102417, "1044": 0.08513788133859634, "1045": 0.11865071207284927, "1060": 0.5220900774002075, "1998": 0.06520967930555344, "2004": 0.08603433519601822, "20... | 14663842 | Oncogenic mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in several types of cancer, but the metabolic consequences of these genetic changes are not fully understood. In this study, we performed (13)C metabolic flux analysis on a panel of isogenic cell lines containing heterozygous IDH1/2 mutations. We ob... | IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism. |
{"1011": 0.2105647772550583, "1020": 0.7898768186569214, "1040": 0.6603899002075195, "1045": 0.2786078155040741, "2006": 0.3443928062915802, "2020": 0.10906458646059036, "2029": 0.22782009840011597, "2050": 0.43623676896095276, "2072": 0.6759096384048462, "2076": 0.19381128251552582, "2077": 0.4462870955467224, "2078":... | 14664424 | The aim of this study is to determine the prognostic value of tumor markers, as squamous cell carcinoma antigen (SCCAg) and cytokeratin-19 fragment (CYFRA 21.1) and interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), soluble tumor necrosis factor receptor I (sTNF RI), and sTNF RII in patients with squamous... | The assessment of the prognostic value of tumor markers and cytokines as SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease |
{"1011": 0.08603433519601822, "1014": 0.3423145115375519, "1017": 0.1808556467294693, "1020": 0.1718502640724182, "1023": 0.3346569836139679, "1040": 0.5893046259880066, "1041": 0.0174254160374403, "1044": 0.5635144114494324, "1045": 0.31560876965522766, "1048": 0.0317181795835495, "1052": 0.57457035779953, "1058": 0.2... | 14672919 | The aim of this study is to search the most powerful prognostic factor from routine blood test for esophageal squamous cell cancer (ESCC) patients. Multiple laboratory tests were evaluated including those reflecting red blood cell parameters (hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin c... | Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients |
{"1014": 0.5139457583427429, "1018": 0.14939609169960022, "1019": 0.12556517124176025, "1023": 0.23092569410800934, "1997": 0.10026945173740387, "2001": 0.12470348179340363, "2004": 0.42735910415649414, "2012": 0.0174254160374403, "2018": 0.05970508232712746, "2020": 0.21765978634357452, "2035": 0.029824240133166313, "... | 14682243 | BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia than in high-income countries. We assessed incidence of dementia according to criteria from the 10/66 Dementia Research Group and Diagnostic and Statistical Manual of Mental Disorders (DS... | Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study |
{"1037": 0.025073638185858727, "1041": 0.0038986403960734606, "1051": 0.4709797203540802, "1058": 0.5947071313858032, "1996": 0.13243216276168823, "1999": 0.1358480453491211, "2003": 0.18654440343379974, "2004": 0.04487626627087593, "2005": 0.24248650670051575, "2008": 0.05970508232712746, "2013": 0.3877306580543518, "... | 14692646 | Extracellular vesicles, including exosomes, are small membrane vesicles derived from multivesicular bodies or from the plasma membrane. Most, if not all, cell types release extracellular vesicles, which then enter the bodily fluids. These vesicles contain a subset of proteins, lipids and nucleic acids that are derived ... | Regulation of immune responses by extracellular vesicles |
{"1014": 0.39433568716049194, "1048": 0.5444341897964478, "1997": 0.2447827309370041, "2011": 0.0842406153678894, "2012": 0.0752234235405922, "2013": 0.12038381397724152, "2039": 0.1905880719423294, "2044": 0.440646231174469, "2045": 0.09228714555501938, "2058": 0.5562619566917419, "2060": 0.23864774405956268, "2084": ... | 14700857 | OBJECTIVES To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental, occupational, and medical diagnostic exposures. DESIGN Multinational retrospective cohort study of cancer mortality. SETTI... | Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries. |
{"1011": 0.06977381557226181, "1043": 0.6451379656791687, "1050": 0.23633737862110138, "1052": 1.0668635368347168, "2003": 0.13670019805431366, "2005": 0.31204116344451904, "2029": 0.10291612148284912, "2078": 0.15943801403045654, "2099": 1.0264055728912354, "2109": 0.20501139760017395, "2147": 0.0797421783208847, "219... | 14706752 | The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75(NTR) is required for p75(NTR)-mediated glioma invasion, a... | Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor |
{"1011": 0.2184450328350067, "1014": 0.255429208278656, "1018": 0.151916041970253, "1020": 0.19782574474811554, "1050": 0.056018441915512085, "1051": 0.7144040465354919, "1052": 0.5092619061470032, "1058": 0.4425300657749176, "1999": 0.983511209487915, "2001": 0.05046287178993225, "2003": 0.016465263441205025, "2005": ... | 14711483 | CONTEXT Vaso-occlusion is central to the painful crises and acute and chronic organ damage in sickle cell disease. Abnormal nitric oxide-dependent regulation of vascular tone, adhesion, platelet activation, and inflammation contributes to the pathophysiology of vaso-occlusion. Nitric oxide may have promise as a mechani... | Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. |
{"1011": 0.21293537318706512, "1039": 0.7115318179130554, "1047": 0.37907835841178894, "1055": 0.755608320236206, "2005": 0.04953393340110779, "2015": 0.129004567861557, "2061": 0.7978238463401794, "2062": 0.129004567861557, "2064": 0.27564704418182373, "2067": 0.15777134895324707, "2075": 0.2954642176628113, "2079": 0... | 14717213 | Over the years, methods of cytogenetic analysis evolved and became part of routine laboratory testing, providing valuable diagnostic and prognostic information in hematologic disorders. Karyotypic aberrations contribute to the understanding of the molecular pathogenesis of disease and thereby to rational application of... | Corresponding author: |
{"1014": 0.34023189544677734, "1019": 0.037378571927547455, "1043": 1.1425544023513794, "2008": 0.026976587250828743, "2019": 0.5033760666847229, "2029": 0.0752234235405922, "2035": 0.5376120805740356, "2038": 0.029824240133166313, "2042": 0.319873183965683, "2045": 0.15943801403045654, "2057": 0.040196798741817474, "2... | 14717500 | Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been convincingly replicated. It is generally thought that the associated markers reflect the effect of a nea... | Rare Variants Create Synthetic Genome-Wide Associations |
{"1006": 0.304147332906723, "1007": 0.2089812457561493, "1009": 1.034073829650879, "1011": 0.15275461971759796, "1016": 0.9029204845428467, "1039": 0.6048921346664429, "1051": 0.24248650670051575, "2003": 0.1477125883102417, "2011": 0.18816383183002472, "2012": 0.09050461649894714, "2015": 0.3163207769393921, "2024": 0... | 14719322 | Cytoplasmic Ca(2+) oscillations are a universal signaling mode that activates numerous cellular responses [1, 2]. Oscillations are considered the physiological mechanism of Ca(2+) signaling because they occur at low levels of stimulus intensity [3]. Ca(2+) oscillations are proposed to convey information in their amplit... | Decoding of Cytoplasmic Ca2+ Oscillations through the Spatial Signature Drives Gene Expression |
{"1011": 0.08961215615272522, "1019": 0.20580662786960602, "1020": 0.49982786178588867, "1022": 0.1229778528213501, "1041": 0.5590575933456421, "1043": 0.678390383720398, "1050": 0.2026219218969345, "1051": 0.8109301924705505, "1052": 0.29400965571403503, "2005": 0.20102575421333313, "2007": 0.3019835948944092, "2012":... | 14724693 | CONTEXT Chronic low back pain (LBP) with degenerative lumbar osteoarthritis (OA) is widespread in the adult population. Although glucosamine is increasingly used by patients with chronic LBP, little is known about its effect in this setting. OBJECTIVE To investigate the effect of glucosamine in patients with chronic LB... | Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial. |
{"1003": 0.07431721687316895, "1014": 0.11430477350950241, "1051": 0.5805994272232056, "1999": 0.304147332906723, "2007": 0.37974658608436584, "2018": 0.0317181795835495, "2020": 0.09406650811433792, "2021": 0.0029254043474793434, "2035": 0.07068414986133575, "2039": 0.04953393340110779, "2045": 0.08154398202896118, "2... | 14726759 | BACKGROUND AND PURPOSE There are only few small studies assessing potential risk factors, comorbidity, and prognostic factors in adult spontaneous cervicocerebral artery dissection (CAD). METHODS We conducted a retrospective, hospital-based analysis on the prognostic factors and association of CAD with vascular risk fa... | Adult cervicocerebral artery dissection: a single-center study of 301 Finnish patients. |
{"1022": 0.05970508232712746, "1023": 0.07068414986133575, "1042": 0.5393219590187073, "1043": 0.15526613593101501, "1050": 0.056018441915512085, "1052": 0.4914994537830353, "1053": 0.16442140936851501, "2002": 0.6583697199821472, "2010": 0.10993985831737518, "2042": 0.04953393340110779, "2057": 0.03925827145576477, "2... | 14729253 | BACKGROUND Data on genetic susceptibility to sporadic gastric carcinoma have been published at a growing pace, but to date no comprehensive overview and quantitative summary has been available. METHODS We conducted a systematic review and meta-analysis of the evidence on the association between DNA variation and risk o... | Genetic variation and gastric cancer risk: a field synopsis and meta-analysis. |
{"1011": 0.2990913391113281, "1013": 0.10731173306703568, "1017": 0.16276304423809052, "1038": 0.4093637466430664, "1039": 0.06703783571720123, "1043": 0.13414156436920166, "1996": 0.6228629946708679, "1998": 0.26146242022514343, "2003": 0.010684899985790253, "2011": 0.26820653676986694, "2012": 0.11604541540145874, "2... | 14753395 | Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB), blood-CSF barrier and the arachnoid barrier. The BBB at the level of brain microvessel endothelium is the maj... | Structure and function of the blood–brain barrier |
{"1009": 0.23864774405956268, "1011": 0.012615402229130268, "1056": 1.0828639268875122, "1996": 0.0842406153678894, "2005": 0.27044451236724854, "2008": 0.0842406153678894, "2011": 0.052318159490823746, "2026": 0.8323994874954224, "2029": 0.2711893916130066, "2041": 0.004870930220931768, "2072": 0.08513788133859634, "2... | 14767844 | Calcium influx is crucial for T cell activation and differentiation. The detailed regulation of this process remains unclear. We report here that golli protein, an alternatively spliced product of the myelin basic protein gene, plays a critical role in regulating calcium influx in T cells. Golli-deficient T cells were ... | Golli protein negatively regulates store depletion-induced calcium influx in T cells. |
{"1011": 0.11517547070980072, "1017": 0.036437395960092545, "1022": 0.35813871026039124, "1039": 0.7067264318466187, "2007": 0.23324857652187347, "2008": 0.013579257763922215, "2011": 0.24631060659885406, "2015": 0.6353566646575928, "2026": 0.4431571960449219, "2029": 0.029824240133166313, "2033": 0.5444341897964478, "... | 14768471 | Renal carcinomas have been shown to contain a population of cancer stem cells (CSCs) that present self-renewing capacity and support tumor growth and metastasis. CSCs were shown to secrete large amount of extracellular vesicles (EVs) that can transfer several molecules (proteins, lipids and nucleic acids) and induce ep... | Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells |
{"1023": 0.10993985831737518, "1043": 0.6149744987487793, "1044": 0.49686139822006226, "1050": 0.3019835948944092, "1052": 0.5381823778152466, "1999": 0.11604541540145874, "2004": 0.6338034868240356, "2007": 0.13755162060260773, "2011": 0.2741633653640747, "2012": 0.13670019805431366, "2026": 0.5278670787811279, "2029"... | 14782049 | The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role in these impairments. To understand the biochemical mechanisms of hippocampal injury in chronic hypoxia... | In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus. |
{"1011": 0.18573370575904846, "1013": 0.06429435312747955, "1018": 0.417115718126297, "1052": 0.020300358533859253, "1058": 1.02149498462677, "2004": 0.0174254160374403, "2005": 0.22001366317272186, "2008": 0.12038381397724152, "2025": 0.20580662786960602, "2029": 0.3930181860923767, "2053": 0.0019512200960889459, "207... | 14797520 | Nuclear transcription is not restricted to genes but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The functional significance of this widespread noncoding transcription is mostly unknown. We show that Arabidopsis RNA polymerase IVb/Pol V, a multisubunit nuclear enzyme required for siRNA-m... | Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes |
{"1011": 0.04113444685935974, "1048": 0.6043586730957031, "1050": 0.2470736801624298, "1056": 1.0389231443405151, "1997": 0.03831886500120163, "1999": 0.25088030099868774, "2007": 0.24554696679115295, "2011": 0.4067663550376892, "2012": 0.4531385898590088, "2013": 0.026976587250828743, "2026": 0.4311734735965729, "2029... | 14803797 | Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethylamine abundant in red meat, also pro... | Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis |
{"1003": 0.06154331564903259, "1014": 0.29036402702331543, "1020": 0.007782140281051397, "1023": 0.06886265426874161, "1038": 0.5990082025527954, "1039": 0.7286425232887268, "1044": 0.0038986403960734606, "2001": 0.053244512528181076, "2002": 1.0409941673278809, "2004": 0.5495203733444214, "2005": 0.4400174915790558, "... | 14806256 | CONTEXT Use of antiretroviral drugs, including protease inhibitors, for treatment of human immunodeficiency virus (HIV) infection has been anecdotally associated with hepatotoxicity, particularly in persons coinfected with hepatitis C or B virus. OBJECTIVES To ascertain if incidence of severe hepatotoxicity during anti... | Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. |
{"1011": 0.3464667797088623, "1017": 0.6374238729476929, "1020": 0.1064341589808464, "1041": 0.10731173306703568, "1047": 0.18167030811309814, "1052": 0.9628462791442871, "1060": 0.5209306478500366, "2001": 0.045809537172317505, "2004": 0.02412080205976963, "2005": 0.11517547070980072, "2006": 0.41065993905067444, "200... | 14819804 | The novel phosphatidylinositol-3-kinase (PI3K) inhibitor PX-866 was tested against 13 experimental human tumor xenografts derived from cell lines of various tissue origins. Mutant PI3K (PIK3CA) and loss of PTEN activity were sufficient, but not necessary, as predictors of sensitivity to the antitumor activity of the PI... | Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. |
{"1014": 0.2918238639831543, "1023": 0.01934296265244484, "1043": 0.8674615025520325, "2001": 0.12986256182193756, "2011": 0.3883931338787079, "2012": 0.4950772523880005, "2020": 0.083342544734478, "2042": 0.2881702482700348, "2043": 0.1685553640127182, "2044": 0.28597161173820496, "2058": 0.4891071021556854, "2076": 0... | 14823313 | OBJECTIVES To examine trends in life expectancy at birth and age and cause specific patterns of mortality in the former German Democratic Republic (GDR) and Poland during political transition and throughout the 1990s in both parts of Germany and in Poland. METHODS Decomposition of life expectancy by age and cause of de... | Changing mortality patterns in East and West Germany and Poland. II: short-term trends during transition and in the 1990s. |
{"1039": 0.42608439922332764, "1042": 0.6603899002075195, "1051": 0.5936289429664612, "2003": 0.030771657824516296, "2004": 0.3499138653278351, "2005": 0.5410289764404297, "2007": 0.36426326632499695, "2015": 0.6573580503463745, "2019": 0.5607312321662903, "2021": 0.07884006202220917, "2029": 0.06977381557226181, "2034... | 14827874 | CONTEXT For the last 40 yr, the first line of treatment for anovulation in infertile women has been clomiphene citrate (CC). CC is a safe, effective oral agent but is known to have relatively common antiestrogenic endometrial and cervical mucous side effects that could prevent pregnancy in the face of successful ovulat... | 0021-972X/06/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 91(3):760–771 Printed in U.S.A. Copyright © 2006 by The Endocrine Society doi: 10.1210/jc.2005-1923 REVIEW: Aromatase Inhibitors for Ovulation Induction |
{"1040": 0.4574742913246155, "1052": 0.5696102976799011, "2000": 0.2501201331615448, "2003": 0.3916989266872406, "2005": 0.0842406153678894, "2019": 0.0354953333735466, "2045": 0.07884006202220917, "2050": 1.175042748451233, "2064": 0.20818853378295898, "2109": 0.3304552733898163, "2200": 0.176772341132164, "2203": 0.3... | 14831629 | Patent ductus arteriosus (PDA) is a common diagnosis among extremely premature infants, especially in those with lung disease. Treatments are often used to close the PDA. Despite nearly three decades of research, the question of whether the benefits of treatments to prevent ductal patency or promote closure outweigh th... | Patent ductus arteriosus: lack of evidence for common treatments. |
{"1038": 0.7163142561912537, "1056": 0.7163142561912537, "1999": 0.18411032855510712, "2005": 0.495672345161438, "2007": 0.41389304399490356, "2011": 0.23556606471538544, "2029": 0.053244512528181076, "2034": 0.08154398202896118, "2045": 0.10291612148284912, "2050": 0.3353555500507355, "2064": 0.05046287178993225, "207... | 14834714 | In recent years, the treatment of autoimmune diseases has been significantly advanced by the use of biological agents. However, some biologics are accompanied with severe side effects, including tuberculosis and other types of infection. There is thus a critical need for nonsystemic and lesion-specific methods of deliv... | Gene therapy of arthritis with TCR isolated from the inflamed paw. |
{"1050": 0.3615458607673645, "1051": 0.5635144114494324, "1055": 0.5290185213088989, "1996": 0.11951763927936554, "1999": 0.2247048318386078, "2008": 0.015504186972975731, "2011": 0.5495203733444214, "2013": 0.1913948506116867, "2029": 0.2763880789279938, "2031": 0.043007105588912964, "2038": 0.23710809648036957, "2042... | 14835068 | Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N-acetyltransferase (AANAT/SNAT) is localized in mitochondria of oocytes and the isolated mitochondria generate melatonin. We have also speculated... | Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics |
{"1053": 0.1011524572968483, "2001": 0.0752234235405922, "2006": 0.09228714555501938, "2020": 0.3353555500507355, "2031": 0.1889725625514984, "2037": 0.20977331697940826, "2038": 0.0752234235405922, "2076": 0.3622259199619293, "2079": 0.014542185701429844, "2092": 0.0770333781838417, "2096": 0.029824240133166313, "2104... | 14843502 | BACKGROUND Self-reported health status in underserved population of prisoners has not been extensively explored. The purposes of this cross-sectional study were to assess self-reported health, quality of life, and access to health services in a sample of male prisoners of Italy. METHODS A total of 908 prisoners receive... | Self-reported health status and access to health services in a sample of prisoners in Italy |
{"1001": 0.011650617234408855, "1015": 0.14095009863376617, "1038": 0.3923587501049042, "1039": 0.4041621685028076, "1044": 0.6892333030700684, "1052": 0.026976587250828743, "1999": 0.2576959431171417, "2003": 0.175953671336174, "2008": 0.13755162060260773, "2011": 0.37707099318504333, "2029": 0.2105647772550583, "2053... | 14848619 | Hypoxia is a common cause of cell death and is implicated in many disease processes including stroke and chronic degenerative disorders. In response to hypoxia, cells express a variety of genes, which allow adaptation to altered metabolic demands, decreased oxygen demands, and the removal of irreversibly damaged cells.... | BH3-only Protein Noxa Is a Mediator of Hypoxic Cell Death Induced by Hypoxia-inducible Factor 1α |
{"1043": 0.5734702348709106, "2002": 0.03831886500120163, "2010": 1.013020396232605, "2015": 0.21687394380569458, "2020": 0.07341018319129944, "2029": 0.1510767638683319, "2049": 0.22079704701900482, "2063": 1.004473328590393, "2076": 0.020300358533859253, "2079": 0.12470348179340363, "2114": 0.0174254160374403, "2121"... | 14853989 | Autoantibodies to DNA and histones (chromatin) are the defining antigen specificity in systemic lupus erythematosus (SLE) and related musculoskeletal disorders but the mechanisms responsible for their induction remain mysterious. That situation rapidly changed once neutrophil extracellular chromatin traps (NETs) were d... | Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity |
{"1011": 0.11256109178066254, "1042": 0.3070250153541565, "1998": 0.03925827145576477, "2005": 0.2667117714881897, "2007": 0.13414156436920166, "2008": 0.03360854089260101, "2011": 0.7701805830001831, "2029": 0.41840189695358276, "2058": 0.23787821829319, "2076": 0.08692999184131622, "2092": 0.10026945173740387, "2109"... | 14863011 | Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and wh... | Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability |
{"1011": 0.24631060659885406, "1015": 0.31560876965522766, "1016": 0.6629094481468201, "1017": 0.47827014327049255, "1040": 0.3963087201118469, "1042": 0.04674193635582924, "1044": 0.42926809191703796, "2008": 0.05694137513637543, "2011": 0.3949938118457794, "2028": 0.12470348179340363, "2029": 0.22392450273036957, "20... | 14864285 | Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) formation phenotype. The Age phen... | YOKO HONDA AND SHUJI HONDA 1 |
{"2003": 0.49864232540130615, "2005": 0.09584271162748337, "2008": 0.00875066313892603, "2011": 0.129004567861557, "2024": 0.23710809648036957, "2064": 0.16276304423809052, "2079": 0.22937409579753876, "2152": 0.306306391954422, "2179": 0.040196798741817474, "2204": 0.4337083101272583, "2303": 0.35128939151763916, "231... | 14865329 | Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rap... | Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders |
{"1041": 0.46363574266433716, "1043": 0.34715715050697327, "1044": 0.6317287683486938, "1051": 0.9827804565429688, "1054": 0.3070250153541565, "2011": 0.2184450328350067, "2029": 0.21135559678077698, "2058": 0.37371641397476196, "2064": 0.11691460013389587, "2076": 0.10291612148284912, "2079": 0.09317722171545029, "208... | 14874811 | Oxygen (O2) deprivation, or hypoxia, has profound effects on cell metabolism and growth. Cells can adapt to low O2 in part through activation of hypoxia-inducible factor (HIF). We report here that hypoxia inhibits mRNA translation by suppressing multiple key regulators, including eIF2alpha, eEF2, and the mammalian targ... | Hypoxia-induced energy stress regulates mRNA translation and cell growth. |
{"1011": 0.14939609169960022, "1040": 0.500420093536377, "1042": 0.05786345899105072, "1043": 0.41065993905067444, "1045": 0.35334911942481995, "1055": 0.4855078160762787, "1999": 0.04953393340110779, "2004": 0.14939609169960022, "2007": 0.29400965571403503, "2011": 0.13157635927200317, "2029": 0.3601844012737274, "203... | 14893425 | The loss of a glutamic acid residue in the AAA-ATPase (ATPases associated with diverse cellular activities) torsinA is responsible for most cases of early onset autosomal dominant primary dystonia. In this study, we found that snapin, which binds SNAP-25 (synaptosome-associated protein of 25,000 Da) and enhances the as... | The dystonia-associated protein torsinA modulates synaptic vesicle recycling. |
{"1041": 0.10467668622732162, "1996": 0.14602625370025635, "1999": 0.022212404757738113, "2000": 0.07341018319129944, "2003": 0.006812678650021553, "2005": 0.13670019805431366, "2006": 0.3464667797088623, "2011": 0.21530038118362427, "2015": 0.14264501631259918, "2028": 0.06429435312747955, "2044": 0.22001366317272186,... | 14893428 | This protocol describes a basic method for in vivo electroporation in the nervous system of embryonic mice. Delivery of electric pulses following microinjection of DNA into the brain ventricle or the spinal cord central canal enables efficient transfection of genes into the nervous system. Transfection is facilitated b... | In vivo electroporation in the embryonic mouse central nervous system |
{"1009": 0.02792670577764511, "1011": 0.10731173306703568, "1017": 0.15693697333335876, "1019": 0.30486753582954407, "1039": 0.5805994272232056, "1054": 0.1064341589808464, "1999": 0.04767346754670143, "2000": 0.27712854743003845, "2007": 0.083342544734478, "2013": 0.3353555500507355, "2015": 0.26146242022514343, "2034... | 14915566 | Debate exists over how to incorporate information from multipartite sequence data in phylogenetic analyses. Strict combined-data approaches argue for concatenation of all partitions and estimation of one evolutionary history, maximizing the explanatory power of the data. Consensus/independence approaches endorse a two-... | Hierarchical phylogenetic models for analyzing multipartite sequence data. |
{"1011": 0.14433705806732178, "1012": 0.10467668622732162, "1022": 0.25088030099868774, "1061": 0.8813109993934631, "1998": 0.12384103983640671, "2003": 0.0606246218085289, "2007": 0.13071982562541962, "2015": 0.15610189735889435, "2024": 0.0174254160374403, "2029": 0.007782140281051397, "2034": 0.08692999184131622, "2... | 14920021 | Gold standard datasets on protein complexes are key to inferring and validating protein-protein interactions. Despite much progress in characterizing protein complexes in the yeast Saccharomyces cerevisiae, numerous researchers still use as reference the manually curated complexes catalogued by the Munich Information C... | Up-to-date catalogues of yeast protein complexes |
{"1011": 0.21135559678077698, "1016": 0.03360854089260101, "1019": 0.9287132620811462, "1041": 0.05786345899105072, "1044": 0.16359257698059082, "1052": 0.11865071207284927, "1999": 0.029824240133166313, "2011": 0.2822965085506439, "2012": 0.24631060659885406, "2029": 0.3084607720375061, "2033": 0.6441128253936768, "20... | 14923462 | Pluripotent stem cells (PSCs) occupy a spectrum of reversible molecular states ranging from a naive ground-state in 2i, to metastable embryonic stem cells (ESCs) in serum, to lineage-primed epiblast stem cells (EpiSCs). To investigate the role of DNA methylation (5mC) across distinct pluripotent states, we mapped genom... | Synergistic Mechanisms of DNA Demethylation during Transition to Ground-State Pluripotency |
{"1003": 0.10203468054533005, "1011": 0.0009760859538801014, "1044": 0.18004031479358673, "1996": 0.011650617234408855, "2037": 0.04860413447022438, "2038": 0.0029254043474793434, "2044": 0.1602703034877777, "2047": 0.06246116757392883, "2063": 0.4788752794265747, "2076": 0.0317181795835495, "2101": 0.5690577030181885,... | 14924526 | Febrile (fever-induced) seizures affect 3–5% of infants and young children. Despite the high incidence of febrile seizures, their contribution to the development of epilepsy later in life has remained controversial. Combining a new rat model of complex febrile seizures and patch clamp techniques, we determined that hyp... | Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits |
{"1011": 0.0770333781838417, "1014": 0.5540198087692261, "1017": 0.22001366317272186, "1020": 0.5612884759902954, "1998": 0.08782484382390976, "2008": 0.058784693479537964, "2011": 0.23864774405956268, "2013": 0.13499516248703003, "2029": 0.11081436276435852, "2038": 0.08513788133859634, "2050": 0.3485364317893982, "20... | 14926162 | The short stem and midrib (ssm) mutants of Arabidopsis thaliana show both semi-dwarf and wavy leaf phenotypes due to defects in the elongation of the stem internodes and leaves. Moreover, these abnormalities cannot be recovered by exogenous phytohormones. ssm was originally identified as a single recessive mutant of th... | Identification of an allele of VAM3/SYP22 that confers a semi-dwarf phenotype in Arabidopsis thaliana. |
{"1006": 0.14518201351165771, "1007": 0.11430477350950241, "1009": 1.0560526847839355, "1011": 0.11517547070980072, "1013": 0.03925827145576477, "1020": 0.175953671336174, "1022": 0.7352184057235718, "1038": 0.6970458030700684, "1039": 0.5773153901100159, "1040": 0.5833279490470886, "1047": 0.9409833550453186, "1048": ... | 14934137 | CD8(+) T cells are required for protective immunity against intracellular pathogens such as Listeria monocytogenes. In this study, we used class Ia MHC-deficient mice, which have a severe reduction in circulating CD8(+) T cells, to determine the protective capacity of class Ib MHC-restricted T cells during L. monocytog... | Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against Listeria monocytogenes infection. |
{"1011": 0.29400965571403503, "1015": 0.5707147121429443, "1040": 0.02316705882549286, "1048": 0.18004031479358673, "1052": 0.18654440343379974, "1055": 0.5833279490470886, "1056": 0.7592713832855225, "2003": 0.23247487843036652, "2028": 0.2837681770324707, "2029": 0.1229778528213501, "2039": 0.4113073945045471, "2063"... | 14938990 | Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the developme... | Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene |
{"1038": 0.06246116757392883, "1043": 0.5381823778152466, "1045": 0.3910386264324188, "1996": 0.025073638185858727, "1999": 0.31132611632347107, "2003": 0.4419025182723999, "2006": 0.272677481174469, "2008": 0.0058422754518687725, "2011": 0.22782009840011597, "2029": 0.27786844968795776, "2073": 0.20580662786960602, "2... | 14965508 | Podocalyxin is the major sialoprotein in the glycocalyx of glomerular podocytes. Here we report on its extraglomerular localization, using a monospecific antibody which was obtained by affinity purification of IgG on nitrocellulose transfers of glomerular podocalyxin. By indirect immunofluorescence, podocalyxin was fou... | Endothelial cell membranes contain podocalyxin--the major sialoprotein of visceral glomerular epithelial cells |
{"1011": 0.1873544454574585, "1017": 0.02792670577764511, "1018": 0.6476961374282837, "1041": 0.46608972549438477, "1043": 0.4974553883075714, "1044": 0.7057625651359558, "1051": 0.07884006202220917, "1052": 0.6317287683486938, "1155": 0.32553088665008545, "1156": 0.22937409579753876, "1997": 0.1221139207482338, "1999"... | 14972169 | Exposure during the organogenesis stage of the mouse embryo to the model teratogen, hydroxyurea (HU), induces curly tail and limb malformations. Oxidative stress contributes to the developmental toxicity of HU. Reactive oxygen species (ROS) interact with polyunsaturated bilipid membranes to form α,β-unsaturated reactiv... | Teratogen-Induced Oxidative Stress Targets Glyceraldehyde-3-Phosphate Dehydrogenase in the Organogenesis Stage Mouse Embryo |
{"1003": 0.15442965924739838, "1019": 0.026025565341114998, "1020": 0.21135559678077698, "1023": 0.09228714555501938, "1039": 0.10379679501056671, "1040": 0.4132472574710846, "1048": 0.10906458646059036, "1054": 0.06795065850019455, "1058": 0.5718178153038025, "2007": 0.7067264318466187, "2018": 0.07884006202220917, "2... | 14973286 | A small proportion of patients with deep vein thrombosis develop recurrent venous thromboembolic complications or bleeding during anticoagulant treatment. These complications may occur more frequently if these patients have concomitant cancer. This prospective follow-up study sought to determine whether in thrombosis p... | Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. |
{"1011": 0.1401015669107437, "1016": 0.022212404757738113, "1043": 0.3910386264324188, "1049": 0.2786078155040741, "1998": 0.14602625370025635, "1999": 0.021256839856505394, "2000": 0.1212492436170578, "2007": 0.0354953333735466, "2048": 0.42926809191703796, "2064": 0.004870930220931768, "2075": 0.0797421783208847, "20... | 15040589 | BACKGROUND Multilevel models (MLM) offer complex survey data analysts a unique approach to understanding individual and contextual determinants of public health. However, little summarized guidance exists with regard to fitting MLM in complex survey data with design weights. Simulation work suggests that analysts shoul... | Fitting multilevel models in complex survey data with design weights: Recommendations |
{"1014": 0.2674594223499298, "1020": 0.5145297050476074, "1023": 0.16690383851528168, "1039": 0.1064341589808464, "1043": 0.45870962738990784, "1044": 0.4337083101272583, "1045": 0.1994270235300064, "1052": 0.12384103983640671, "1053": 0.4196864068508148, "1609": 0.22782009840011597, "1997": 0.3262358605861664, "1998":... | 15041758 | OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condition collaborative care for depression and poorly controlled diabetes and/or risk factors for coronary heart di... | Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial |
{"1016": 0.2231435477733612, "1054": 0.02887592278420925, "1997": 0.08244366943836212, "2001": 0.036437395960092545, "2015": 0.3170322775840759, "2042": 0.01934296265244484, "2051": 0.31132611632347107, "2058": 0.018384648486971855, "2076": 0.12556517124176025, "2095": 0.006812678650021553, "2102": 0.6317287683486938, ... | 15048300 | BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectiveness analyses are often based on randomised clinical trials (RCTs). The objective of this study was to evaluate the external validity of published cost-effectiveness studies by comparing the data used in these studies (typically bas... | A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example |
{"1011": 0.20580662786960602, "1016": 0.5517725944519043, "1021": 0.823009729385376, "1038": 0.5816917419433594, "1041": 1.3175804615020752, "1043": 0.8780695199966431, "1048": 0.1229778528213501, "2001": 0.11081436276435852, "2003": 0.3070250153541565, "2004": 0.014542185701429844, "2005": 0.06795065850019455, "2008":... | 15058155 | EBI2, aka GPR183, is a G-couple receptor originally identified in 1993 as one of main genes induced in Burkitt's lymphoma cell line BL41 by Epstein-Barr virus (EBV) infection. After it was reported in 2009 that the receptor played a key role in regulating B cell migration and responses, we initiated an effort in lookin... | 7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases |
{"1011": 0.22937409579753876, "1055": 0.6441128253936768, "1056": 0.3170322775840759, "1058": 0.2918238639831543, "1060": 0.3784096837043762, "1999": 0.16524957120418549, "2005": 0.2089812457561493, "2008": 0.1602703034877777, "2011": 0.1970241367816925, "2029": 0.3777405619621277, "2057": 0.020300358533859253, "2064":... | 15077696 | DNA damage can stall the DNA replication machinery, leading to genomic instability. Thus, numerous mechanisms exist to complete genome duplication in the absence of a pristine DNA template, but identification of the enzymes involved remains incomplete. Here, we establish that Primase-Polymerase (PrimPol; CCDC111), an a... | PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication |
{"1011": 0.18411032855510712, "1015": 0.2918238639831543, "1018": 0.6338034868240356, "1038": 0.7500885725021362, "1042": 0.5244048833847046, "1045": 0.1332872211933136, "1048": 0.7764897346496582, "1056": 0.6149744987487793, "1999": 0.09672962874174118, "2004": 0.0606246218085289, "2005": 0.022212404757738113, "2008":... | 15081770 | We previously reported a strong IL4I1 gene expression in primary mediastinal B-cell lymphoma (PMBL) and recently identified the protein as a secreted L-phenylalanine oxidase, physiologically expressed by myeloid cells, which inhibits T-cell proliferation in vitro. Here, we analyzed the pattern of IL4I1 protein expressi... | The novel immunosuppressive enzyme IL4I1 is expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages |
{"1011": 0.18248429894447327, "1017": 0.6629094481468201, "1045": 0.9553611874580383, "1052": 0.5318912267684937, "2003": 0.1212492436170578, "2004": 0.058784693479537964, "2005": 0.0913962796330452, "2006": 0.6563454270362854, "2011": 0.06520967930555344, "2014": 0.7683706283569336, "2029": 0.083342544734478, "2062": ... | 15113221 | Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no reliable test for PI3K pathway activation exists for human tumors. Taking advantage of the observation that loss of PTEN, the negative r... | Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. |
{"1011": 0.18573370575904846, "1046": 0.7370892763137817, "1056": 0.02412080205976963, "1058": 0.3464667797088623, "1999": 0.08064348995685577, "2008": 0.05417001247406006, "2011": 0.19862671196460724, "2026": 1.0158531665802002, "2029": 0.3106105625629425, "2036": 0.04394211992621422, "2072": 0.736154317855835, "2076"... | 15121114 | Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, in the bloodstream of its mammalian host to evade the host immune response. VSGs are expressed exclusively from subtelomeric loci, and we have previously shown that telomere proteins TbTIF2 and TbRAP1 play imp... | Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity |
{"1009": 0.822151780128479, "1011": 0.14433705806732178, "1015": 0.11256109178066254, "1016": 0.32270604372024536, "1018": 0.5051454305648804, "1022": 0.1889725625514984, "1038": 0.6522845029830933, "1049": 0.8212929964065552, "1056": 1.013020396232605, "2000": 0.004870930220931768, "2003": 0.1994270235300064, "2006": ... | 15128866 | Metastatic melanoma is a rapidly progressing disease with high mortality rate and limited treatment options. Immunotherapy based on tumor-targeting cytotoxic T cell responses represents a promising strategy. To assist in its development, we examined the possibility and efficacy of using CD4+ cytotoxic T cells. The regu... | CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade |
{"1039": 0.9546096324920654, "1044": 0.669430673122406, "1058": 0.016465263441205025, "1999": 0.053244512528181076, "2001": 0.35403475165367126, "2002": 1.1864371299743652, "2010": 0.42225050926208496, "2013": 0.2711893916130066, "2018": 0.09406650811433792, "2020": 0.13670019805431366, "2031": 0.08782484382390976, "20... | 15129362 | Hepatitis C virus (HCV) is a leading cause of liver cancer and cirrhosis, and Egypt has possibly the highest HCV prevalence worldwide. In this article we use a newly developed Bayesian inference framework to estimate the transmission dynamics of HCV in Egypt from sampled viral gene sequences, and to predict the public ... | The epidemiology and iatrogenic transmission of hepatitis C virus in Egypt: a Bayesian coalescent approach. |
{"2000": 0.2516399025917053, "2025": 0.5063233375549316, "2062": 0.10203468054533005, "2064": 0.26820653676986694, "2071": 0.04207121208310127, "2084": 0.11168810725212097, "2092": 0.4145384132862091, "2103": 0.4126010537147522, "2109": 0.5127768516540527, "2111": 0.255429208278656, "2129": 0.26146242022514343, "2140":... | 15135001 | This paper highlights methods for using geospatial analysis to assess, enhance, and improve recruitment efforts to ensure representativeness in study populations. We apply these methods to the Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis (MURDOCK) study, a longitudinal population health ... | Improving population representation through geographic health information systems: mapping the MURDOCK study. |
{"1011": 0.27786844968795776, "1044": 0.2786078155040741, "1049": 0.11430477350950241, "1060": 0.02316705882549286, "2000": 0.09495500475168228, "2002": 0.259204238653183, "2003": 0.012615402229130268, "2006": 0.02792670577764511, "2013": 0.18492233753204346, "2015": 0.2711893916130066, "2029": 0.08244366943836212, "20... | 15153602 | The direct detection of haplotypes from short-read DNA sequencing data requires changes to existing small-variant detection methods. Here, we develop a Bayesian statistical framework which is capable of modeling multiallelic loci in sets of individuals with non-uniform copy number. We then describe our implementation o... | Haplotype-based variant detection from short-read sequencing |
{"1021": 0.28963330388069153, "1022": 0.20660123229026794, "1023": 0.319873183965683, "1038": 0.7836518287658691, "1039": 0.22859740257263184, "1043": 0.9379299283027649, "1052": 0.4330752193927765, "1055": 0.6186635494232178, "1058": 0.020300358533859253, "1060": 0.42990362644195557, "1061": 0.8281423449516296, "2007"... | 15155862 | Cardiovascular disease (CVD) is the leading cause of death worldwide. Recent genome-wide association (GWA) studies have pinpointed many loci associated with CVD risk factors in adults. It is unclear, however, if these loci predict trait levels at all ages, if they are associated with how a trait develops over time, or ... | Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study |
{"1011": 0.1685553640127182, "1039": 0.4938860833644867, "1042": 0.7610978484153748, "1996": 0.04207121208310127, "1999": 0.1808556467294693, "2006": 0.06154331564903259, "2011": 0.39367714524269104, "2029": 0.05694137513637543, "2046": 0.034552380442619324, "2049": 0.06246116757392883, "2058": 0.4349733293056488, "207... | 15176526 | Epidermal homeostasis depends on a balance between stem cell renewal and differentiation and is regulated by extrinsic signals from the extracellular matrix (ECM). A powerful approach to analysing the pathways involved is to engineer single-cell microenvironments in which individual variables are precisely and quantita... | Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions |
{"1003": 0.03266380727291107, "1011": 0.04953393340110779, "1014": 0.37640097737312317, "1016": 0.272677481174469, "1018": 0.15860503911972046, "1019": 0.0317181795835495, "1021": 0.02792670577764511, "1022": 0.14518201351165771, "1053": 1.225611925125122, "1055": 0.09584271162748337, "1056": 0.5871354341506958, "1999"... | 15194125 | This study investigated interobserver (two observers) and intrasubject (two measurements) reproducibility of QT dispersion from abnormal electrocardiograms in patients with previous myocardial infarction, and compared a user-interactive with an automatic measurement system. Standard 12-lead electrocardiograms, recorded... | Reproducibility and automatic measurement of QT dispersion. |
{"1011": 0.021256839856505394, "1015": 0.053244512528181076, "1043": 0.9100211262702942, "1048": 0.7445381283760071, "1998": 0.04394211992621422, "2003": 0.2539152204990387, "2004": 0.10555581003427505, "2005": 0.2317005842924118, "2006": 0.2317005842924118, "2007": 0.3601844012737274, "2010": 0.6118015646934509, "2011... | 15215393 | Glioblastoma multiforme (GBM) is a particularly aggressive brain tumor and remains a clinically devastating disease. Despite innovative therapies for the treatment of GBM, there has been no significant increase in patient survival over the past decade. Enzymes that control epigenetic alterations are of considerable int... | Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. |
{"1014": 0.17840765416622162, "1048": 0.11951763927936554, "1052": 0.5778634548187256, "1055": 0.0842406153678894, "1062": 0.35128939151763916, "1999": 0.09850110858678818, "2000": 0.2394166737794876, "2005": 0.3956514894962311, "2007": 0.0029254043474793434, "2013": 0.35128939151763916, "2019": 0.4318077862262726, "20... | 15237660 | BACKGROUND Long-lasting insecticide treated nets (LLINs) and indoor residual house spraying (IRS) are the main interventions for the control of malaria vectors in Zanzibar. The aim of the present study was to assess the susceptibility status of malaria vectors against the insecticides used for LLINs and IRS and to dete... | Challenges for malaria elimination in Zanzibar: pyrethroid resistance in malaria vectors and poor performance of long-lasting insecticide nets |
{"1011": 0.10467668622732162, "1043": 0.6170841455459595, "1052": 0.5506471395492554, "2003": 0.255429208278656, "2011": 0.2470736801624298, "2026": 0.6054253578186035, "2029": 0.17020416259765625, "2058": 0.46363574266433716, "2076": 0.45251765847206116, "2152": 0.11865071207284927, "2166": 0.36967599391937256, "2235"... | 15248287 | Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the molecular mechanisms of which are only partially elucidated. In this study, we describe a survival pathway controlled by proliferating cell nuclear antigen (PCNA), a nuclear factor involved in DNA replication and repairing of ... | Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival |
{"1996": 0.03831886500120163, "1997": 0.18329764902591705, "1999": 0.05694137513637543, "2013": 0.2749055027961731, "2015": 0.08603433519601822, "2020": 0.12470348179340363, "2034": 0.5151132941246033, "2039": 0.5784112811088562, "2043": 0.19220098853111267, "2044": 0.4311734735965729, "2047": 0.2976420819759369, "2048... | 15274349 | Almost immediately after a human being is born, so too is a new microbial ecosystem, one that resides in that person's gastrointestinal tract. Although it is a universal and integral part of human biology, the temporal progression of this process, the sources of the microbes that make up the ecosystem, how and why it v... | Development of the Human Infant Intestinal Microbiota |
{"1011": 0.23787821829319, "1013": 0.23092569410800934, "1041": 0.4145384132862091, "1042": 0.07068414986133575, "1043": 0.9958525896072388, "1048": 0.3526630103588104, "1052": 0.5784112811088562, "1156": 0.41195443272590637, "1165": 0.42608439922332764, "1998": 0.05139094591140747, "1999": 0.022212404757738113, "2000"... | 15282056 | Phosphoenolpyruvate (PEP) is an important precursor for anaerobic production of succinate and malate. Although inactivating PEP/carbohydrate phosphotransferase systems (PTS) could increase PEP supply, the resulting strain had a low glucose utilization rate. In order to improve anaerobic glucose utilization rate for eff... | Combinatorial modulation of galP and glk gene expression for improved alternative glucose utilization |
{"1011": 0.009718249551951885, "1013": 0.32764431834220886, "1041": 0.9769153594970703, "1053": 1.0881409645080566, "1054": 0.3339579105377197, "1055": 0.6374238729476929, "1062": 0.004870930220931768, "2003": 0.1485546976327896, "2005": 0.13157635927200317, "2012": 0.4654768109321594, "2015": 0.08603433519601822, "201... | 15286783 | Expression quantitative trait loci (eQTL) mapping aims to determine genomic regions that regulate gene transcription. Expression QTL is used to study the regulatory structure of normal tissues and to search for genetic factors in complex diseases such as cancer, diabetes, and cystic fibrosis. A modern eQTL dataset cont... | Matrix eQTL: Ultra fast eQTL analysis via large matrix operations |
{"1011": 0.052318159490823746, "1040": 0.3615458607673645, "1997": 0.022212404757738113, "2003": 0.0029254043474793434, "2005": 0.25995752215385437, "2008": 0.02412080205976963, "2013": 0.05417001247406006, "2024": 0.15359249711036682, "2028": 0.02316705882549286, "2029": 0.01934296265244484, "2044": 0.2961907088756561... | 15305881 | Deinococcus spp. are renowned for their amazing ability to recover rapidly from severe genomic fragmentation as a result of exposure to extreme levels of ionizing radiation or desiccation. Despite having been originally characterized over 50 years ago, the mechanism underlying this remarkable repair process is still po... | The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins |
{"1011": 0.012615402229130268, "1014": 0.5092619061470032, "1015": 0.7583568692207336, "1022": 0.567397952079773, "1044": 0.45499902963638306, "1047": 0.7755908370018005, "1049": 0.07884006202220917, "1050": 0.7276995778083801, "1052": 0.5685047507286072, "1061": 0.32129061222076416, "1062": 0.5707147121429443, "1091":... | 15319019 | Background The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date map to the polymerase domain of the enzyme.... | N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance |
{"1011": 0.04487626627087593, "1013": 0.24018502235412598, "1042": 0.6527929902076721, "1054": 0.7692760229110718, "1055": 0.8004589080810547, "1999": 0.006812678650021553, "2003": 0.02792670577764511, "2011": 0.2539152204990387, "2024": 0.040196798741817474, "2029": 0.2881702482700348, "2048": 0.1970241367816925, "205... | 15322518 | Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here, we employ an integrated molecular profiling and chemical biology approach to de... | Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors |
{"1011": 0.03831886500120163, "1016": 0.46055975556373596, "1019": 0.2969166338443756, "1056": 0.014542185701429844, "1060": 0.6699305176734924, "1997": 0.1734936386346817, "1999": 0.029824240133166313, "2000": 0.17840765416622162, "2007": 0.1011524572968483, "2025": 0.12642613053321838, "2028": 0.029824240133166313, "... | 15327601 | Very often, the positions of flexible domains within macromolecules as well as within macromolecular complexes cannot be determined by standard structural biology methods. To overcome this problem, we developed a method that uses probabilistic data analysis to combine single-molecule measurements with X-ray crystallogr... | A nano-positioning system for macromolecular structural analysis |
{"1011": 0.08692999184131622, "1017": 0.12556517124176025, "1020": 0.1602703034877777, "1022": 0.1011524572968483, "1041": 0.669430673122406, "1044": 0.4067663550376892, "1051": 0.42096930742263794, "1998": 0.06612417846918106, "1999": 0.18654440343379974, "2000": 0.10026945173740387, "2007": 0.2689530849456787, "2011"... | 15335331 | BACKGROUND Both tumor-associated macrophages (TAMs) and the epithelial to mesenchymal transition (EMT) of cancer cells play key roles in promoting tumor progression. However, whether TAMs could induce EMT in the progression of oral squamous cell carcinoma (OSCC) remains undefined. RESULTS Here we detected the expressio... | Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma |
{"1011": 0.12556517124176025, "1039": 0.6212902665138245, "1046": 0.7370892763137817, "1050": 0.4337083101272583, "1051": 0.18654440343379974, "1059": 0.6931471824645996, "2006": 0.00875066313892603, "2011": 0.20501139760017395, "2013": 0.21214580535888672, "2015": 0.6070231795310974, "2026": 0.8517522215843201, "2029"... | 15337254 | Significant efforts have been directed to understanding the factors that influence the lineage commitment of stem cells. This paper demonstrates that cell shape, independent of soluble factors, has a strong influence on the differentiation of human mesenchymal stem cells (MSCs) from bone marrow. When exposed to competi... | Geometric cues for directing the differentiation of mesenchymal stem cells. |
{"100": 0.19862671196460724, "1011": 0.04674193635582924, "1017": 0.030771657824516296, "1018": 0.037378571927547455, "1037": 0.841701865196228, "1055": 0.5668440461158752, "1156": 0.7656494975090027, "1996": 0.014542185701429844, "1999": 0.03831886500120163, "2020": 0.058784693479537964, "2029": 0.0797421783208847, "2... | 15347087 | The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (AD). Nonetheless, it now seems increasingly unlikely that amyloid toxicity is the cause of sporadic AD, which leads to cognitive decline. Here, using accelerated-sene... | Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats |
{"1013": 0.1685553640127182, "1014": 0.5827828645706177, "1017": 0.2674594223499298, "1019": 0.19862671196460724, "1020": 0.3485364317893982, "1043": 0.41065993905067444, "1044": 0.12384103983640671, "1048": 0.4462870955467224, "1058": 0.8281423449516296, "1997": 0.0317181795835495, "2004": 0.757441520690918, "2007": 0... | 15360986 | We compared low-density lipoprotein cholesterol (LDL) values obtained by the Friedewald formula--i.e., total cholesterol minus high-density lipoprotein (HDL) cholesterol minus very-low-density lipoprotein (VLDL) cholesterol (estimated as triglyceride divided by 5)--with those obtained by lipoprotein fractionation, usin... | Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints. |
{"1011": 0.11081436276435852, "1017": 0.5186077356338501, "1021": 0.25845035910606384, "1040": 0.10203468054533005, "1042": 0.09850110858678818, "1043": 0.3141832649707794, "1045": 0.38905516266822815, "1047": 0.38441169261932373, "1052": 0.40546512603759766, "1060": 0.5220900774002075, "1999": 0.0038986403960734606, "... | 15365719 | The motor protein Kif3a and primary cilia regulate important developmental processes, but their roles in skeletogenesis remain ill-defined. Here we created mice deficient in Kif3a in cartilage and focused on the cranial base and synchondroses. Kif3a deficiency caused cranial base growth retardation and dysmorphogenesis... | Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. |
{"1011": 0.06520967930555344, "1015": 0.19782574474811554, "1021": 0.06886265426874161, "1022": 0.5865923762321472, "1023": 0.21922965347766876, "1038": 0.20580662786960602, "1041": 0.2394166737794876, "1045": 0.06429435312747955, "1051": 0.6471850275993347, "1155": 0.2576959431171417, "1999": 0.0174254160374403, "2003... | 15381976 | Asthma is one of the most common inflammatory diseases characterized by airway hyperresponsiveness, inflammation, and remodeling. Morin, an active ingredient obtained from Moraceae plants, has been demonstrated to have promising anti-inflammatory activities in a range of disorders. However, its impacts on pulmonary dis... | Morin Attenuates Ovalbumin-Induced Airway Inflammation by Modulating Oxidative Stress-Responsive MAPK Signaling. |
{"1011": 0.2531573474407196, "1015": 0.3949938118457794, "1048": 0.2539152204990387, "1056": 0.6613984704017639, "1996": 0.2822965085506439, "1999": 0.10467668622732162, "2015": 0.0797421783208847, "2028": 0.24631060659885406, "2029": 0.14179791510105133, "2063": 0.7333439588546753, "2064": 0.08513788133859634, "2090":... | 15405204 | The expression of self-antigen in the thymus is believed to be responsible for the deletion of autoreactive T lymphocytes, a critical process in the maintenance of unresponsiveness to self. The Autoimmune regulator (Aire) gene, which is defective in the disorder autoimmune polyglandular syndrome type 1, has been shown ... | Spontaneous autoimmunity prevented by thymic expression of a single self-antigen |
{"1011": 0.06246116757392883, "1048": 0.7086513638496399, "1052": 0.8195732831954956, "1996": 0.27712854743003845, "1999": 0.3656192123889923, "2003": 0.009718249551951885, "2005": 0.03925827145576477, "2007": 0.13499516248703003, "2011": 0.2184450328350067, "2020": 0.0058422754518687725, "2029": 0.1212492436170578, "2... | 15414628 | Legionella pneumophila, the causative agent of Legionnaires' pneumonia, resides in a distinct vacuole structure called Legionella-containing vacuole (LCV). The LCV resists fusion with the lysosome and permits efficient bacterial replication in host macrophages, which requires a Dot/Icm type IVB secretion system. Dot/Ic... | Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. |
{"1005": 0.0752234235405922, "1011": 0.6833335757255554, "1015": 0.3297532796859741, "1019": 0.7124901413917542, "1040": 0.2447827309370041, "1045": 0.861702561378479, "1050": 0.26296505331993103, "1054": 0.1677299439907074, "1998": 0.09584271162748337, "2002": 0.5712664127349854, "2003": 0.30917787551879883, "2008": 0... | 15419873 | Retinoic acid inducible-gene I (RIG-I) is a cytosolic multidomain protein that detects viral RNA and elicits an antiviral immune response. Two N-terminal caspase activation and recruitment domains (CARDs) transmit the signal, and the regulatory domain prevents signaling in the absence of viral RNA. 5'-triphosphate and ... | Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA. |
{"1011": 0.3519764244556427, "1045": 0.034552380442619324, "1048": 0.3134697377681732, "1056": 0.6363908052444458, "2007": 0.0058422754518687725, "2011": 0.2659635543823242, "2012": 0.07250232994556427, "2015": 0.5261374711990356, "2029": 0.1913948506116867, "2063": 0.1358480453491211, "2071": 0.1734936386346817, "2076... | 15425958 | Interleukin-10 (IL-10) suppresses the maturation and cytokine production of dendritic cells (DCs), key regulators of adaptive immunity, and prevents the activation and polarization of naïve T cells towards protective gamma interferon-producing effectors. We hypothesized that human cytomegalovirus (HCMV) utilizes its vi... | Human Cytomegalovirus-Encoded Interleukin-10 Homolog Inhibits Maturation of Dendritic Cells and Alters Their Functionality |
{"1011": 0.10291612148284912, "1040": 0.8550800085067749, "1043": 0.48068851232528687, "1061": 0.015504186972975731, "1996": 0.08064348995685577, "1997": 0.2317005842924118, "1999": 0.03266380727291107, "2006": 0.19541899859905243, "2007": 0.0029254043474793434, "2011": 0.034552380442619324, "2012": 0.02602556534111499... | 15426878 | A model for the unidirectional movement of dynein is presented based on structural observations and biochemical experimental results available. In this model, the binding affinity of dynein for microtubule is independent of its nucleotide state and the change between strong and weak microtubule-binding is determined na... | Model for unidirectional movement of axonemal and cytoplasmic dynein molecules |
{"1009": 0.11430477350950241, "1011": 0.14179791510105133, "1017": 0.4537591338157654, "1048": 0.15860503911972046, "1056": 0.4855078160762787, "1996": 0.3283478021621704, "1999": 0.947819709777832, "2003": 0.12470348179340363, "2011": 0.28450319170951843, "2026": 0.3339579105377197, "2029": 0.1751343309879303, "2044":... | 15435343 | The inflammasome is a proteolysis complex that generates the active forms of the proinflammatory cytokines interleukin (IL)-1β and IL-18. Inflammasome activation is mediated by NLR proteins that respond to microbial and nonmicrobial stimuli. Among NLRs, NLRP3 senses the widest array of stimuli and enhances adaptive imm... | The inflammasome component NLRP3 impairs antitumor vaccine by enhancing the accumulation of tumor-associated myeloid-derived suppressor cells. |
{"1011": 0.25239890813827515, "1047": 0.3012613356113434, "1048": 0.42990362644195557, "1050": 0.15023678541183472, "1056": 0.5069117546081543, "2000": 0.0174254160374403, "2003": 0.1485546976327896, "2005": 0.38574060797691345, "2008": 0.09761575609445572, "2013": 0.4093637466430664, "2024": 0.3485364317893982, "2029"... | 15462523 | Natural killer (NK) cells are potent cytotoxic effector cells for cancer therapy and potentially for severe viral infections. However, there are technical challenges to obtain sufficient numbers of functionally active NK cells from a patient's blood since they represent only 10% of the lymphocytes and are often dysfunc... | Natural Killer Cells for Immunotherapy – Advantages of the NK-92 Cell Line over Blood NK Cells |
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