spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.4944818615913391, "1047": 0.920189380645752, "1052": 1.0560526847839355, "1997": 0.07612881064414978, "1998": 0.15526613593101501, "2003": 0.006812678650021553, "2004": 0.04113444685935974, "2006": 0.04860413447022438, "2008": 0.08244366943836212, "2011": 0.0354953333735466, "2024": 0.14602625370025635, "202... | 15472716 | DNA-PKcs and Ku are essential components of the complex that catalyzes non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Ku, a heterodimeric protein, binds to DNA ends and facilitates recruitment of the catalytic subunit, DNA-PKcs. We have investigated the effect of DNA strand orientation and sequen... | Differential activation of DNA-PK based on DNA strand orientation and sequence bias |
{"1015": 0.1619328260421753, "1043": 0.31489628553390503, "1047": 0.02316705882549286, "1052": 0.9546096324920654, "1056": 0.12038381397724152, "1609": 0.021256839856505394, "2004": 0.0354953333735466, "2005": 0.151916041970253, "2008": 0.13499516248703003, "2029": 0.2034190446138382, "2034": 0.21530038118362427, "2038... | 15473205 | The African trypanosome, Trypanosoma brucei, maintains an integral link between cell cycle regulation and differentiation during its intricate life cycle. Whilst extensive changes in phosphorylation have been documented between the mammalian bloodstream form and the insect procyclic form, relatively little is known abo... | Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen |
{"1009": 0.010684899985790253, "1014": 0.33675122261047363, "1016": 0.04953393340110779, "1017": 0.05139094591140747, "1020": 0.037378571927547455, "1038": 0.40546512603759766, "1039": 0.6038249135017395, "1040": 0.3903779089450836, "1042": 0.06520967930555344, "1052": 0.630689799785614, "1053": 0.8861536383628845, "20... | 15476777 | BACKGROUND Elderly and frail patients with cancer, although often treated with chemotherapy, are under-represented in clinical trials. We designed FOCUS2 to investigate reduced-dose chemotherapy options and to seek objective predictors of outcome in frail patients with advanced colorectal cancer. METHODS We undertook a... | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial |
{"1051": 0.16110190749168396, "1061": 0.1693800985813141, "1997": 0.009718249551951885, "1999": 0.07341018319129944, "2005": 0.08692999184131622, "2011": 0.2659635543823242, "2029": 0.14264501631259918, "2030": 1.1965231895446777, "2038": 0.1677299439907074, "2083": 0.020300358533859253, "2100": 0.817850649356842, "211... | 15478227 | The wild species of the genus Oryza contain a largely untapped reservoir of agronomically important genes for rice improvement. Here we report the 261-Mb de novo assembled genome sequence of Oryza brachyantha. Low activity of long-terminal repeat retrotransposons and massive internal deletions of ancient long-terminal ... | Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution |
{"1014": 0.4624064862728119, "1026": 0.08692999184131622, "1051": 0.011650617234408855, "1052": 0.46486347913742065, "1056": 0.07793712615966797, "1060": 0.14518201351165771, "2004": 0.03266380727291107, "2007": 0.2539152204990387, "2053": 0.40089741349220276, "2064": 0.5347557663917542, "2067": 0.7067264318466187, "20... | 15482274 | OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisations, when compared with standard palpation methods, and whether ultrasound imaging can reduce traumatic procedures, insertion attempts, and needle redirections. DESIGN Systematic review and meta-ana... | Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis. |
{"1038": 1.034073829650879, "1041": 1.0641717910766602, "1042": 0.4349733293056488, "1043": 0.940220832824707, "1996": 0.015504186972975731, "2005": 0.11951763927936554, "2008": 0.03266380727291107, "2011": 0.3070250153541565, "2029": 0.2409527748823166, "2036": 0.35334911942481995, "2079": 0.07612881064414978, "2084":... | 15488881 | Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, but the signals that guide responding B cells to these alternative compartment... | Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. |
{"1011": 0.2223619967699051, "1015": 0.1734936386346817, "1038": 0.630689799785614, "1052": 0.32270604372024536, "2004": 0.08154398202896118, "2015": 0.8861536383628845, "2025": 0.0019512200960889459, "2029": 0.23710809648036957, "2033": 0.7755908370018005, "2037": 0.10203468054533005, "2038": 0.0174254160374403, "2043... | 15491308 | Human mesenchymal stem cells (MSCs) have therapeutic potential because of their ability to self-renew and differentiate into multiple tissues. However, senescence often occurs in MSCs when they are cultured in vitro and the molecular mechanisms underlying this effect remain unclear. In this study, we found that NAD-dep... | SIRT1 is required for long-term growth of human mesenchymal stem cells |
{"1011": 0.10203468054533005, "1042": 0.8550800085067749, "1043": 0.6862877607345581, "1996": 0.43875885009765625, "1997": 0.1229778528213501, "1998": 0.08961215615272522, "2003": 0.10731173306703568, "2004": 0.02792670577764511, "2008": 0.0029254043474793434, "2011": 0.25694093108177185, "2029": 0.27786844968795776, "... | 15491404 | The synapse is a highly organized cellular specialization whose structure and composition are reorganized, both positively and negatively, depending on the strength of input signals. The mechanisms orchestrating these changes are not well understood. A plausible locus for the reorganization of synapse components and st... | Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity |
{"1996": 0.34577593207359314, "1999": 0.03266380727291107, "2015": 0.28155985474586487, "2069": 0.15693697333335876, "2073": 0.3388410806655884, "2076": 0.2160874605178833, "2079": 0.5472630262374878, "2109": 0.08692999184131622, "2110": 0.5080875158309937, "2112": 0.27786844968795776, "2147": 0.19622190296649933, "216... | 15493354 | Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt the structure of the CNS, refine neuronal circuitry and network connec... | Sublime Microglia: Expanding Roles for the Guardians of the CNS |
{"1041": 0.24859806895256042, "1051": 0.304147332906723, "2001": 0.1905880719423294, "2007": 0.31132611632347107, "2012": 0.0770333781838417, "2018": 0.42799583077430725, "2020": 0.36697331070899963, "2025": 0.02792670577764511, "2031": 0.25845035910606384, "2038": 0.09228714555501938, "2040": 0.06337817758321762, "204... | 15512462 | OBJECTIVE To compare the incidence of cancer among women with and without a history of pre-eclampsia. DESIGN Cohort study. SETTING Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-76. PARTICIPANTS 37 033 women. MAIN OUTCOME MEASURES Age adjusted and multivariable a... | Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort. |
{"1022": 0.10906458646059036, "1052": 0.23324857652187347, "2001": 0.010684899985790253, "2003": 0.17840765416622162, "2033": 0.5415972471237183, "2034": 0.09584271162748337, "2039": 0.1677299439907074, "2042": 0.15442965924739838, "2043": 0.0038986403960734606, "2058": 0.010684899985790253, "2063": 0.25995752215385437... | 15521377 | Cellular senescence is a stable form of cell-cycle arrest which is thought to limit the proliferative potential of premalignant cells [1]. The senescence phenotype was initially described by Hayflick and Moorhead in 1961 on human fibroblasts undergoing replicative exhaustion in culture [2]. It has been shown that senes... | Keeping your senescent cells under control |
{"1055": 0.3248254358768463, "1158": 0.5936289429664612, "1996": 0.2105647772550583, "2029": 0.2160874605178833, "2050": 0.34922540187835693, "2076": 0.10731173306703568, "2078": 0.3084607720375061, "2079": 0.6704301834106445, "2188": 0.7809720039367676, "2232": 0.12814582884311676, "2303": 0.20421554148197174, "2378":... | 15535511 | Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostasis. To define the role of insulin receptor (IR) signaling in this circuitry, we inactivated IR signaling in tyrosine hydroxylase (Th)-expressing cells of mice (IR(ΔTh)). IR inactiv... | Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. |
{"2001": 0.2822965085506439, "2003": 0.013579257763922215, "2011": 0.28450319170951843, "2022": 0.12038381397724152, "2040": 0.8699195384979248, "2042": 0.26446542143821716, "2043": 0.38441169261932373, "2047": 0.30989447236061096, "2052": 0.06795065850019455, "2071": 0.3956514894962311, "2083": 0.3910386264324188, "20... | 15541119 | Anticancer agents go through a process by which their antitumor activity, on the basis of the amount of tumor shrinkage they could generate, has been investigated. In the late 1970s, the International Union Against Cancer and the World Health Organization (WHO) introduced specific criteria for the codification of tumor... | [New guidelines to evaluate the response to treatment in solid tumors]. |
{"1009": 0.43053874373435974, "1011": 0.11256109178066254, "1043": 0.7018978595733643, "1045": 0.9271688461303711, "1050": 0.5984715819358826, "1062": 1.0430610179901123, "1996": 0.14939609169960022, "1997": 0.1510767638683319, "1999": 0.09761575609445572, "2007": 0.4067663550376892, "2008": 0.15359249711036682, "2011"... | 15548965 | Ionotropic glutamate receptor (iGluR) subunits contain a large N-terminal domain (NTD) that precedes the agonist-binding domain (ABD) and participates in subunit oligomerization. In NMDA receptors (NMDARs), the NTDs of NR2A and NR2B subunits also form binding sites for the endogenous inhibitor Zn(2+) ion. Although thes... | Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition |
{"1049": 0.6265231370925903, "1166": 0.1970241367816925, "1997": 0.0317181795835495, "1999": 0.21922965347766876, "2000": 0.14518201351165771, "2005": 0.23556606471538544, "2011": 0.19220098853111267, "2012": 0.11517547070980072, "2026": 1.0430610179901123, "2029": 0.13157635927200317, "2033": 0.10555581003427505, "203... | 15551129 | Many species of mycobacteria form structured biofilm communities at liquid–air interfaces and on solid surfaces. Full development of Mycobacterium smegmatis biofilms requires addition of supplemental iron above 1 μM ferrous sulphate, although addition of iron is not needed for planktonic growth. Microarray analysis of ... | The role of iron in Mycobacterium smegmatis biofilm formation: the exochelin siderophore is essential in limiting iron conditions for biofilm formation but not for planktonic growth |
{"1998": 0.3170322775840759, "1999": 0.3656192123889923, "2007": 0.28743788599967957, "2013": 0.083342544734478, "2014": 0.1477125883102417, "2020": 0.08961215615272522, "2029": 0.3560888469219208, "2039": 0.29109421372413635, "2044": 0.36358460783958435, "2058": 0.010684899985790253, "2062": 0.43623676896095276, "2076... | 15559582 | In a comparative study of pre- and postmenopausal women with benign and malignant breast disease, a number of differences were observed in circulating plasma prolactin and lipid concentrations. Plasma lipids, phospholipids, triglycerides, cholesterol and free fatty acids were all higher in blood obtained from breast ca... | Plasma lipids and prolactin in patients with breast cancer. |
{"1018": 0.056018441915512085, "1020": 0.3683255612850189, "1040": 0.26446542143821716, "1044": 0.574020504951477, "1048": 0.06154331564903259, "1050": 0.17922431230545044, "2003": 0.11517547070980072, "2004": 0.07068414986133575, "2007": 0.3304552733898163, "2011": 0.11517547070980072, "2012": 0.21214580535888672, "20... | 15561961 | Hypercholesterolemia is associated with impairments in endothelium-dependent vascular relaxations. Paradoxically, endothelial production of nitrogen oxides is increased in early stages of hypercholesterolemia. Prior work has shown that oxidized low density lipoprotein (LDL) has both stimulatory and inhibitory effects o... | expression by oxidized linoleic |
{"1011": 0.17431432008743286, "1017": 0.469759464263916, "1020": 0.13670019805431366, "1038": 0.2018241584300995, "1041": 1.1481462717056274, "1043": 0.4203280806541443, "1047": 0.3485364317893982, "1048": 0.6588751673698425, "1050": 0.1685553640127182, "1052": 0.6828403472900391, "1999": 0.052318159490823746, "2003": ... | 15563864 | Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, is an antioxidant with chemopreventive and chemotherapeutic actions. Based on its ability to modulate growth factor-mediated cell proliferation, we evaluated its efficacy in multiple myeloma (MM). EGCG induced both dose- and time-dependent growth... | Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications. |
{"1011": 0.12384103983640671, "1013": 0.04953393340110779, "1018": 0.37371641397476196, "1020": 0.7565253376960754, "1039": 0.13071982562541962, "1043": 0.6699305176734924, "1047": 0.16110190749168396, "1052": 0.04487626627087593, "1060": 0.6970458030700684, "2005": 0.23324857652187347, "2007": 0.2749055027961731, "202... | 15570691 | Activation of cyclin-dependent kinases 4 and 6 (cdk4/6) occurs in the majority of glioblastoma multiforme (GBM) tumors, and represents a promising molecular target for the development of small molecule inhibitors. In the current study, we investigated the molecular determinants and in vivo response of diverse GBM cell ... | Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. |
{"1011": 0.24631060659885406, "1016": 0.30558720231056213, "1019": 0.018384648486971855, "1041": 0.0029254043474793434, "1044": 0.9155091643333435, "1049": 0.00875066313892603, "1054": 0.6709295511245728, "1055": 0.37907835841178894, "2000": 0.11430477350950241, "2002": 0.16607704758644104, "2015": 0.6254787445068359, ... | 15570962 | We describe an approach for picking haplotype-tagging single nucleotide polymorphisms (htSNPs) that is presently being taken in two large nested case-control studies within a multiethnic cohort (MEC), which are engaged in a search for associations between risk of prostate and breast cancer and common genetic variations... | Choosing Haplotype-Tagging SNPS Based on Unphased Genotype Data Using a Preliminary Sample of Unrelated Subjects with an Example from the Multiethnic Cohort Study |
{"1015": 0.823009729385376, "1040": 0.41840189695358276, "1043": 0.3850763738155365, "1045": 0.06429435312747955, "1996": 0.07884006202220917, "1998": 0.2184450328350067, "2011": 0.23787821829319, "2013": 0.18492233753204346, "2021": 0.07159364968538284, "2028": 0.41195443272590637, "2031": 0.28597161173820496, "2038":... | 15578265 | Several lines of evidence suggest a role for the gut microbiome in type 1 diabetes. Treating diabetes-prone rodents with probiotics or antibiotics prevents the development of the disorder. Diabetes-prone rodents also have a distinctly different gut microbiome compared with healthy rodents. Recent studies in children wi... | A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes |
{"1011": 0.09672962874174118, "2003": 0.6461620330810547, "2005": 0.08244366943836212, "2024": 0.06429435312747955, "2054": 0.037378571927547455, "2075": 0.04860413447022438, "2083": 0.3141832649707794, "2087": 0.09228714555501938, "2109": 0.4734157919883728, "2163": 0.029824240133166313, "2224": 0.38308101892471313, "... | 15588516 | Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expression data and other molecular states into a unified conceptual framework. Although applicable to any system of molecular components and interactions, Cytoscape is most powerful when used in conjunct... | METHODS AND RESULTS |
{"1011": 0.09672962874174118, "1038": 0.8941729068756104, "1040": 0.1889725625514984, "1043": 0.37640097737312317, "1050": 0.037378571927547455, "1997": 0.4879087805747986, "2003": 0.08513788133859634, "2008": 0.004870930220931768, "2011": 0.35060185194015503, "2029": 0.10993985831737518, "2039": 0.2539152204990387, "2... | 15590539 | Control of translation is a fundamental source of regulation in gene expression. The induction of protein synthesis by brain-derived neurotrophic factor (BDNF) critically contributes to enduring modifications of synaptic function, but how BDNF selectively affects only a minority of expressed mRNAs is poorly understood.... | Dual Regulation of miRNA Biogenesis Generates Target Specificity in Neurotrophin-Induced Protein Synthesis |
{"1011": 0.10291612148284912, "1015": 0.2800849378108978, "1016": 0.11168810725212097, "1038": 1.0001721382141113, "1041": 1.0868242979049683, "1048": 0.347847044467926, "1055": 0.3923587501049042, "1158": 0.35813871026039124, "2003": 0.22001366317272186, "2005": 0.15610189735889435, "2006": 0.45251765847206116, "2008"... | 15593561 | Epstein-Barr virus (EBV), an oncogenic human herpesvirus, induces cell proliferation after infection of resting B lymphocytes, its reservoir in vivo. The viral latent proteins are necessary for permanent B cell growth, but it is unknown whether they are sufficient. EBV was recently found to encode microRNAs (miRNAs) th... | A Viral microRNA Cluster Strongly Potentiates the Transforming Properties of a Human Herpesvirus |
{"1011": 0.018384648486971855, "1016": 0.151916041970253, "1041": 0.3005385100841522, "1050": 0.11951763927936554, "1051": 0.4831010699272156, "1054": 0.6223390698432922, "1061": 0.012615402229130268, "2004": 0.3070250153541565, "2005": 0.08961215615272522, "2008": 0.015504186972975731, "2011": 0.0842406153678894, "202... | 15600979 | EMSY links the BRCA2 pathway to sporadic breast/ovarian cancer. It encodes a nuclear protein that binds to the BRCA2 N-terminal domain implicated in chromatin/transcription regulation, but when sporadically amplified/overexpressed, increased EMSY level represses BRCA2 transactivation potential and induces chromosomal i... | EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases |
{"1014": 0.09406650811433792, "1038": 0.1685553640127182, "1042": 0.7656494975090027, "1048": 0.6739205718040466, "1050": 0.2231435477733612, "1052": 0.35950297117233276, "1998": 0.4311734735965729, "1999": 0.28597161173820496, "2005": 0.020300358533859253, "2007": 0.1212492436170578, "2029": 0.026976587250828743, "204... | 15615957 | UNLABELLED Fruit and vegetable consumption has been inversely associated with the risk of chronic diseases including cancer and cardiovascular disease, with the beneficial effects attributed to a variety of protective antioxidants, carotenoids and phytonutrients. The objective of the present study was to determine the ... | Original Article |
{"1011": 0.14602625370025635, "1013": 0.07341018319129944, "1016": 0.30917787551879883, "1024": 0.10467668622732162, "1025": 0.11517547070980072, "1043": 0.7987030148506165, "1050": 0.25467249751091003, "1054": 0.6181373596191406, "1996": 0.11517547070980072, "2003": 0.3005385100841522, "2008": 0.015504186972975731, "2... | 15617300 | The Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) is an international public repository for high-throughput microarray and next-generation sequence functional genomic data sets submitted by the research community. The resource supports archiving of raw data, processed data and metadata which are index... | NCBI GEO: archive for functional genomics data sets—update |
{"1011": 0.083342544734478, "1040": 0.6482070088386536, "1041": 0.6492279767990112, "1051": 0.2223619967699051, "1058": 0.029824240133166313, "2003": 0.25239890813827515, "2004": 0.0354953333735466, "2005": 0.2160874605178833, "2011": 0.24018502235412598, "2013": 0.016465263441205025, "2019": 0.5069117546081543, "2020"... | 15617866 | Paratransgenesis, the genetic manipulation of insect symbiotic microorganisms, is being considered as a potential method to control vector-borne diseases such as malaria. The feasibility of paratransgenic malaria control has been hampered by the lack of candidate symbiotic microorganisms for the major vector Anopheles ... | Viral Paratransgenesis in the Malaria Vector Anopheles gambiae |
{"1011": 0.29255300760269165, "1015": 0.0038986403960734606, "1016": 0.2026219218969345, "1017": 0.3864043951034546, "1041": 0.2837681770324707, "1043": 0.021256839856505394, "1048": 0.7701805830001831, "1057": 0.38441169261932373, "2008": 0.02316705882549286, "2010": 0.5215105414390564, "2011": 0.347847044467926, "201... | 15635366 | L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has not been defined. Here we show that disruption of L3mbtl2 results in embryonic lethality with failure of gastrulation. This correlates with compromised proliferation and abnormal differentiation of L3mbtl2... | The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. |
{"1014": 0.5045560002326965, "1016": 0.08871890604496002, "1052": 0.40220460295677185, "2001": 0.1212492436170578, "2004": 0.8772575259208679, "2020": 0.13670019805431366, "2034": 0.06337817758321762, "2039": 0.22937409579753876, "2044": 0.20501139760017395, "2051": 0.41840189695358276, "2053": 0.1358480453491211, "207... | 15648443 | BACKGROUND Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint. The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a ... | Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial |
{"1011": 0.08782484382390976, "1016": 0.401551216840744, "1043": 0.3723714053630829, "1998": 0.06886265426874161, "1999": 0.08064348995685577, "2005": 0.2711893916130066, "2008": 0.14095009863376617, "2011": 0.34508460760116577, "2012": 0.20501139760017395, "2029": 0.4158279001712799, "2038": 0.012615402229130268, "204... | 15655418 | Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly underst... | Drosophila CPEB Orb2A Mediates Memory Independent of Its RNA-Binding Domain |
{"1009": 0.5145297050476074, "1011": 0.0317181795835495, "1041": 0.021256839856505394, "1043": 0.6684301495552063, "1044": 0.10731173306703568, "1048": 0.5461324453353882, "1052": 0.3995884954929352, "1999": 0.14349138736724854, "2002": 0.6754127144813538, "2004": 0.6689305305480957, "2005": 0.1889725625514984, "2007":... | 15657779 | Little is known about the expression and possible functions of unopposed gap junction hemichannels in the brain. Emerging evidence suggests that gap junction hemichannels can act as stand-alone functional channels in astrocytes. With immunocytochemistry, dye uptake, and HPLC measurements, we show that astrocytes in vit... | Functional hemichannels in astrocytes: a novel mechanism of glutamate release. |
{"1011": 0.3897167444229126, "1037": 0.24859806895256042, "1054": 0.8748174905776978, "2005": 0.09938567131757736, "2007": 0.255429208278656, "2011": 0.3963087201118469, "2012": 0.2539152204990387, "2029": 0.35745587944984436, "2048": 0.42990362644195557, "2076": 0.3304552733898163, "2079": 0.07341018319129944, "2087":... | 15659108 | Rad52 promotes the annealing of complementary strands of DNA bound by replication protein A (RPA) during discrete repair pathways. Here, we used a fluorescence resonance energy transfer (FRET) between two fluorescent dyes incorporated into DNA substrates to probe the mechanism by which human Rad52 (hRad52) interacts wi... | Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52–ssDNA complexes |
{"1011": 0.20818853378295898, "1014": 0.29400965571403503, "1016": 0.5618454217910767, "1038": 0.669430673122406, "1039": 0.562402069568634, "1050": 0.21293537318706512, "1056": 0.6838265657424927, "1999": 0.11604541540145874, "2007": 0.5092619061470032, "2029": 0.17020416259765625, "2035": 0.34922540187835693, "2048":... | 15663829 | BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type natriuretic peptide (BNP) levels in blood and risk of type 2 diabetes (T2D), but the prospective association of BNP with T2D is uncertain, and it is unclear whether the association is confounded. METHODS AND FINDINGS We analy... | Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies |
{"1011": 0.2231435477733612, "1044": 0.1221139207482338, "1051": 0.4487839937210083, "1054": 0.04394211992621422, "1998": 0.08961215615272522, "2029": 0.23787821829319, "2034": 0.24018502235412598, "2048": 0.5646255612373352, "2050": 0.7800771594047546, "2051": 0.2741633653640747, "2073": 0.04113444685935974, "2076": 0... | 15669393 | Transient activation of estrogen receptors (ER) in the developing brain during a limited perinatal "window of time" is recognized as a key mechanism of defeminization of neural control of reproductive function and sexual behavior. Two major ER isoforms, alpha and beta, are present in neural circuits that govern ovarian... | brain organization |
{"1011": 0.05417001247406006, "1041": 0.2954642176628113, "1997": 0.1384023278951645, "2004": 0.04207121208310127, "2015": 0.3903779089450836, "2022": 0.0606246218085289, "2040": 0.77198725938797, "2043": 0.0606246218085289, "2064": 0.10203468054533005, "2072": 0.10555581003427505, "2080": 0.010684899985790253, "2088":... | 15670968 | Many countries use the cost-effectiveness thresholds recommended by the World Health Organization's Choosing Interventions that are Cost-Effective project (WHO-CHOICE) when evaluating health interventions. This project sets the threshold for cost-effectiveness as the cost of the intervention per disability-adjusted lif... | Thresholds for the cost–effectiveness of interventions: alternative approaches |
{"1014": 0.1011524572968483, "1052": 0.2394166737794876, "2001": 0.2501201331615448, "2037": 0.04953393340110779, "2043": 0.2674594223499298, "2076": 0.11865071207284927, "2077": 0.29109421372413635, "2082": 0.6275664567947388, "2086": 0.42926809191703796, "2093": 0.27564704418182373, "2095": 0.1332872211933136, "2106"... | 15678772 | OBJECTIVE To determine whether exposure to low doses of ionising radiation in infancy affects cognitive function in adulthood. DESIGN Population based cohort study. SETTING Sweden. PARTICIPANTS 3094 men who had received radiation for cutaneous haemangioma before age 18 months during 1930-59. MAIN OUTCOME MEASURES Radia... | Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study. |
{"1011": 0.21687394380569458, "1039": 0.17840765416622162, "1047": 0.6931471824645996, "1054": 0.6233867406845093, "1996": 0.1011524572968483, "2006": 0.16276304423809052, "2011": 0.02792670577764511, "2015": 0.28963330388069153, "2029": 0.21372433006763458, "2037": 0.022212404757738113, "2073": 0.04207121208310127, "2... | 15685921 | Patch-clamp recordings were made from retinal ganglion cells in the mouse retina. Under dark adaptation, blockage of BK(Ca) channels increases the spontaneous excitatory postsynaptic currents (EPSCs) and light-evoked On-EPSCs, while it decreases the light-evoked Off inhibitory postsynaptic currents (IPSCs). However, un... | Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina |
{"1011": 0.1677299439907074, "1014": 0.02316705882549286, "1044": 0.9379299283027649, "1048": 0.38441169261932373, "1053": 0.15023678541183472, "1055": 0.06612417846918106, "1062": 0.14095009863376617, "2002": 0.29400965571403503, "2003": 0.1994270235300064, "2015": 1.0444365739822388, "2033": 0.5483922958374023, "2064... | 15692098 | Hutchinson-Gilford progeria syndrome (HGPS) is a rare but well known entity characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble aged persons. Cardiovascular compromise leads to early demise. Cogn... | Hutchinson-Gilford progeria syndrome: review of the phenotype |
{"1040": 0.32553088665008545, "1044": 0.1064341589808464, "1045": 0.4855078160762787, "1048": 0.40741631388664246, "1056": 0.28743788599967957, "2003": 0.34508460760116577, "2063": 0.36358460783958435, "2094": 1.2533208131790161, "2222": 0.15860503911972046, "2250": 0.9929623603820801, "2291": 0.13499516248703003, "233... | 15707049 | Interstitial lung disease (ILD) is a common manifestation of systemic autoimmunity characterized by progressive inflammation or scarring of the lungs. Patients who develop these complications can exhibit significantly impaired gas exchange that may result in hypoxemia, pulmonary hypertension, and even death. Unfortunat... | Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. |
{"1009": 0.030771657824516296, "1011": 0.272677481174469, "1015": 0.38905516266822815, "1045": 0.46117570996284485, "1049": 0.6764062643051147, "1053": 0.5540198087692261, "1056": 0.46055975556373596, "1999": 0.04207121208310127, "2007": 0.0009760859538801014, "2010": 0.7370892763137817, "2011": 0.37102460861206055, "2... | 15716328 | Endoplasmic reticulum (ER)-associated aminopeptidase (ERAP)1 has been implicated in the final proteolytic processing of peptides presented by major histocompatibility complex (MHC) class I molecules. To evaluate the in vivo role of ERAP1, we have generated ERAP1-deficient mice. Cell surface expression of the class Ia m... | In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules |
{"1009": 0.4196864068508148, "1011": 0.011650617234408855, "1015": 0.0770333781838417, "1018": 0.0770333781838417, "1020": 0.10026945173740387, "1023": 0.05786345899105072, "1038": 0.31132611632347107, "1040": 0.6212902665138245, "1043": 0.22937409579753876, "1052": 0.5860490798950195, "2003": 0.2719337046146393, "2005... | 15721252 | INTRODUCTION Alterations in cell cycle regulators have been implicated in human malignancies including breast cancer. PD 0332991 is an orally active, highly selective inhibitor of the cyclin D kinases (CDK)4 and CDK6 with ability to block retinoblastoma (Rb) phosphorylation in the low nanomolar range. To identify predi... | PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro |
{"1011": 0.4318077862262726, "1015": 0.012615402229130268, "1039": 0.5990082025527954, "1047": 1.034073829650879, "1048": 0.7665573358535767, "2000": 0.04767346754670143, "2003": 0.007782140281051397, "2005": 0.09495500475168228, "2007": 0.06429435312747955, "2011": 0.30558720231056213, "2029": 0.058784693479537964, "2... | 15727984 | Non-small cell lung cancer (NSCLC) cells with somatic mutations in K-ras recruit to the tumor a variety of cell types (hereafter collectively termed "stromal cells") that can promote or inhibit tumorigenesis by mechanisms that have not been fully elucidated. Here, we postulated that stromal cells in the tumor microenvi... | Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment. |
{"1048": 0.4500300884246826, "2003": 0.24325250089168549, "2011": 0.05970508232712746, "2029": 0.0174254160374403, "2033": 0.16359257698059082, "2054": 0.04860413447022438, "2062": 0.1212492436170578, "2076": 0.3423145115375519, "2079": 0.08154398202896118, "2084": 0.09050461649894714, "2128": 0.28890204429626465, "213... | 15728433 | Autophagy is a constitutive lysosomal catabolic pathway that degrades damaged organelles and protein aggregates. Stem cells are characterized by self-renewal, pluripotency, and quiescence; their long life span, limited capacity to dilute cellular waste and spent organelles due to quiescence, along with their requiremen... | Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging |
{"1011": 0.18004031479358673, "1012": 0.18004031479358673, "1016": 0.3027053773403168, "1035": 0.09584271162748337, "1044": 0.9754437208175659, "1062": 1.4469189643859863, "1999": 0.022212404757738113, "2002": 0.22392450273036957, "2003": 0.2622140049934387, "2008": 0.030771657824516296, "2010": 0.9021284580230713, "20... | 15778034 | H2A.Z is an evolutionary conserved histone variant involved in transcriptional regulation, antisilencing, silencing, and genome stability. The mechanism(s) by which H2A.Z regulates these various biological functions remains poorly defined, in part due to the lack of knowledge regarding its physical location along chrom... | Variant Histone H2A.Z Is Globally Localized to the Promoters of Inactive Yeast Genes and Regulates Nucleosome Positioning |
{"1050": 0.1873544454574585, "1998": 0.17840765416622162, "2001": 0.012615402229130268, "2012": 0.11081436276435852, "2020": 0.3526630103588104, "2044": 0.5795059204101562, "2061": 0.1485546976327896, "2062": 0.09672962874174118, "2064": 0.24018502235412598, "2071": 0.08244366943836212, "2075": 0.3070250153541565, "207... | 15780826 | BACKGROUND Complex situations that follow war and natural disasters have a psychosocial impact on not only the individual but also on the family, community and society. Just as the mental health effects on the individual psyche can result in non pathological distress as well as a variety of psychiatric disorders; massi... | Collective trauma in northern Sri Lanka: a qualitative psychosocial-ecological study |
{"1011": 0.14179791510105133, "1018": 0.04767346754670143, "1043": 0.0009760859538801014, "1051": 0.4126010537147522, "1053": 0.05694137513637543, "1999": 0.02887592278420925, "2005": 0.18492233753204346, "2007": 0.07068414986133575, "2008": 0.07068414986133575, "2012": 0.11081436276435852, "2029": 0.31845372915267944,... | 15790930 | In the present study, the relationship between short interfering RNA (siRNA) sequence and RNA interference (RNAi) effect was extensively analyzed using 62 targets of four exogenous and two endogenous genes and three mammalian and Drosophila cells. We present the rules that may govern siRNA sequence preference and in ac... | Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. |
{"1018": 0.8583967685699463, "1039": 0.35745587944984436, "1052": 0.3304552733898163, "1060": 0.567397952079773, "2003": 0.4462870955467224, "2064": 0.02887592278420925, "2109": 0.45251765847206116, "2176": 0.4914994537830353, "2193": 0.10467668622732162, "2224": 0.2763880789279938, "2275": 0.07884006202220917, "2291":... | 15795880 | The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of programs and associated data and software libraries which can be used for macromolecular structure determination by X-ray crystallography. The suite is designed to be flexible, allowing users a number of methods of achieving thei... | Overview of the CCP4 suite and current developments |
{"1011": 0.09584271162748337, "1017": 0.0770333781838417, "1018": 0.16359257698059082, "1023": 0.5313173532485962, "1044": 0.44753631949424744, "1047": 0.6941232681274414, "1048": 0.37035053968429565, "1051": 0.35403475165367126, "2002": 1.0560526847839355, "2005": 0.1718502640724182, "2010": 0.7610978484153748, "2011"... | 15803282 | The extremely low efficiency of human embryonic stem cell (hESC) derivation using somatic cell nuclear transfer (SCNT) limits its potential application. Blastocyst formation from human SCNT embryos occurs at a low rate and with only some oocyte donors. We previously showed in mice that reduction of histone H3 lysine 9 ... | Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells. |
{"1040": 0.03360854089260101, "2011": 0.25845035910606384, "2012": 0.22392450273036957, "2028": 0.00875066313892603, "2048": 0.39433568716049194, "2078": 0.19220098853111267, "2079": 0.29981520771980286, "2102": 0.23556606471538544, "2129": 0.013579257763922215, "2135": 0.19622190296649933, "2177": 0.3241194784641266, ... | 15816729 | Although cellular tumor-suppression mechanisms are widely studied, little is known about mechanisms that act at the level of tissues to suppress the occurrence of aberrant cells in epithelia. We find that ectopic expression of transcription factors that specify cell fates causes abnormal epithelial cysts in Drosophila ... | Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation |
{"1013": 0.16110190749168396, "1996": 0.011650617234408855, "1998": 0.05694137513637543, "2006": 0.09938567131757736, "2007": 0.21372433006763458, "2011": 0.2539152204990387, "2029": 0.06977381557226181, "2043": 0.09850110858678818, "2051": 0.38574060797691345, "2064": 0.02792670577764511, "2070": 0.22001366317272186, ... | 15830352 | In some organisms longevity, growth, and developmental rate are improved when they are maintained on a light/dark cycle, the period of which "resonates" optimally with the period of the endogenous circadian clock. However, to our knowledge no studies have demonstrated that reproductive fitness per se is improved by res... | Resonating circadian clocks enhance fitness in cyanobacteria. |
{"1011": 0.16110190749168396, "1015": 0.4932899475097656, "1039": 0.6410312056541443, "1042": 0.083342544734478, "1060": 0.5584990978240967, "1996": 0.09850110858678818, "1999": 0.06246116757392883, "2011": 0.4518963396549225, "2013": 0.40089741349220276, "2015": 0.5882205963134766, "2024": 0.09406650811433792, "2026":... | 15832146 | Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are poorly understood. Using a coimplantation tumor xenograft model, we demonstrate that carcinoma-associated fibroblasts (CAFs) extracted from human breast carcinom... | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion |
{"1019": 0.0606246218085289, "1038": 0.8764448165893555, "1041": 0.3027053773403168, "1996": 0.4932899475097656, "2007": 0.40089741349220276, "2013": 0.14349138736724854, "2015": 0.14686977863311768, "2029": 0.20421554148197174, "2043": 0.38308101892471313, "2051": 0.014542185701429844, "2073": 0.35745587944984436, "20... | 15833835 | Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the types of OB neurons they generate. Here we show that the majority of mouse B1 cell precursors are produced between embryonic days (E... | Embryonic Origin of Postnatal Neural Stem Cells |
{"1011": 0.14602625370025635, "1015": 0.6118015646934509, "1039": 0.3554046154022217, "1051": 0.48670899868011475, "1996": 0.34508460760116577, "2002": 0.6608943343162537, "2004": 0.0354953333735466, "2012": 0.6064908504486084, "2028": 0.2478361576795578, "2029": 0.23864774405956268, "2033": 0.47827014327049255, "2043"... | 15836115 | Mitochondrial morphological and ultrastructural changes occur during apoptosis and autophagy, but whether they are relevant in vivo for tissue response to damage is unclear. Here we investigate the role of the optic atrophy 1 (OPA1)-dependent cristae remodeling pathway in vivo and provide evidence that it regulates the... | The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage |
{"1049": 0.2659635543823242, "1057": 0.11951763927936554, "2000": 0.04767346754670143, "2003": 0.12038381397724152, "2005": 0.1946154683828354, "2012": 0.018384648486971855, "2033": 0.08871890604496002, "2045": 0.056018441915512085, "2055": 0.14349138736724854, "2062": 0.05139094591140747, "2088": 0.5640701055526733, "... | 15856466 | : Advances in stem cell research have triggered scores of studies in regenerative medicine in a large number of institutions and companies around the world. However, reproducibility and data exchange among laboratories or cell banks are constrained by the lack of a standardized format for experiments. To enhance inform... | First Proposal of Minimum Information About a Cellular Assay for Regenerative Medicine |
{"1020": 0.3601844012737274, "1039": 0.5168620347976685, "1052": 0.11604541540145874, "1062": 0.7276995778083801, "1996": 0.4248080551624298, "2001": 0.034552380442619324, "2004": 0.40089741349220276, "2005": 0.04953393340110779, "2007": 0.23864774405956268, "2011": 0.32129061222076416, "2020": 0.16524957120418549, "20... | 15868816 | The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning in the early embryo of C. elegans, and encode six different proteins required for asymmetric cell division by the worm zygote. Some of the PAR proteins are localized asymmetrically and form physical complexes with one another. S... | The PAR proteins: fundamental players in animal cell polarization. |
{"1999": 0.22157983481884003, "2004": 0.05786345899105072, "2007": 0.1693800985813141, "2011": 0.04487626627087593, "2012": 0.06520967930555344, "2013": 0.4311734735965729, "2038": 0.07612881064414978, "2046": 0.472198486328125, "2063": 0.9131608605384827, "2064": 0.07159364968538284, "2071": 0.07431721687316895, "2083... | 15879544 | An unidentified environmental reservoir of infectivity contributes to the natural transmission of prion diseases (transmissible spongiform encephalopathies [TSEs]) in sheep, deer, and elk. Prion infectivity may enter soil environments via shedding from diseased animals and decomposition of infected carcasses. Burial of... | Prions Adhere to Soil Minerals and Remain Infectious |
{"1048": 0.7276995778083801, "1060": 0.38374659419059753, "1998": 0.21135559678077698, "2007": 0.02887592278420925, "2012": 0.6338034868240356, "2029": 0.0029254043474793434, "2099": 0.7018978595733643, "2109": 0.037378571927547455, "2140": 0.47827014327049255, "2188": 0.4764525294303894, "2306": 0.10731173306703568, "... | 15879931 | Inflammation and macrophage foam cells are characteristic features of atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to inflammation and LXR-dependent response pathways are poorly understood. To investigate this relationship, we utilized lipidomic and transcriptomic methods to evaluate the... | Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses |
{"1015": 0.4831010699272156, "1018": 0.5461324453353882, "1043": 1.0101795196533203, "1056": 0.8691008687019348, "1999": 0.1064341589808464, "2011": 0.3560888469219208, "2028": 0.02412080205976963, "2029": 0.12728634476661682, "2062": 0.14264501631259918, "2064": 0.18816383183002472, "2076": 0.11256109178066254, "2078"... | 15889329 | Brain glial cells, five times more prevalent than neurons, have recently received attention for their potential involvement in epileptic seizures. Microglia and astrocytes, associated with inflammatory innate immune responses, are responsible for surveillance of brain damage that frequently results in seizures. Thus, a... | A JOURNAL OF NEUROLOGY |
{"1011": 0.19220098853111267, "1017": 0.4412745535373688, "1039": 0.14518201351165771, "1050": 0.5116065740585327, "1055": 1.013020396232605, "1061": 0.38441169261932373, "1996": 0.12642613053321838, "1997": 0.17431432008743286, "1999": 0.07884006202220917, "2007": 0.5438674688339233, "2011": 0.3982778787612915, "2015"... | 15893330 | Eukaryotic ribosomes assemble by association of ribosomal RNA with ribosomal proteins into nuclear precursor particles, which undergo a complex maturation pathway coordinated by non-ribosomal assembly factors. Here, we provide functional insights into how successive structural re-arrangements in ribosomal protein S3 pr... | Sequential domain assembly of ribosomal protein S3 drives 40S subunit maturation. |
{"1040": 0.5762182474136353, "1042": 0.36290550231933594, "1047": 0.39762192964553833, "2000": 0.2501201331615448, "2007": 0.02792670577764511, "2013": 0.5364705324172974, "2022": 0.0317181795835495, "2041": 0.1685553640127182, "2043": 0.22626367211341858, "2044": 0.11343330889940262, "2046": 0.22782009840011597, "2051... | 15907458 | In this protocol, we describe how to isolate keratinocytes from adult mouse epidermis, fractionate them into different sub-populations on the basis of cell surface markers and examine their function in an in vivo skin reconstitution assay with disaggregated neonatal dermal cells. We also describe how the isolated kerat... | Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis |
{"1011": 0.19381128251552582, "1037": 0.12470348179340363, "1999": 0.13755162060260773, "2004": 0.08603433519601822, "2008": 0.0842406153678894, "2011": 0.17922431230545044, "2024": 0.1946154683828354, "2025": 0.06977381557226181, "2029": 0.2659635543823242, "2031": 0.12556517124176025, "2076": 0.32905077934265137, "21... | 15913433 | Telomerase-negative immortalized human cells maintain their telomeres by a mechanism known as alternative lengthening of telomeres (ALT). We report here that ALT cells contain a novel promyelocytic leukemia (PML) body (ALT-associated PML body, APB). APBs are large donut-shaped nuclear structures containing PML protein,... | Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body. |
{"1003": 0.04767346754670143, "1011": 0.5495203733444214, "1014": 0.3127557039260864, "1026": 0.026976587250828743, "1028": 0.17267228662967682, "1050": 0.47463157773017883, "1052": 0.4574742913246155, "1054": 0.5751199722290039, "2004": 1.0229004621505737, "2012": 0.5381823778152466, "2019": 0.10026945173740387, "2029... | 15925931 | BACKGROUND Whole-body magnetic resonance angiography (WB-MRA) has shown its potential for the non-invasive assessment of nearly the entire arterial vasculature within one examination. Since the presence of extra-cardiac atherosclerosis is associated with an increased risk of coronary events, our goal was to establish t... | Prediction of coronary artery disease by a systemic atherosclerosis score index derived from whole-body MR angiography |
{"1011": 0.26146242022514343, "1015": 0.0842406153678894, "1044": 0.025073638185858727, "1054": 0.5016035437583923, "1055": 0.06795065850019455, "2002": 0.7105726003646851, "2003": 0.05046287178993225, "2011": 0.23864774405956268, "2044": 0.29036402702331543, "2058": 0.5151132941246033, "2062": 0.5301685929298401, "206... | 15926408 | A major challenge each human cell-division cycle is to ensure that DNA replication origins do not initiate more than once, a phenomenon known as re-replication. Acute deregulation of replication control ultimately causes extensive DNA damage, cell-cycle checkpoint activation and cell death whereas moderate deregulation... | Analysis of re-replication from deregulated origin licensing by DNA fiber spreading |
{"1011": 0.5404602885246277, "1015": 0.8315495252609253, "1042": 0.19381128251552582, "1048": 1.259437084197998, "1051": 0.34715715050697327, "1999": 0.08603433519601822, "2003": 0.09584271162748337, "2005": 0.16359257698059082, "2008": 0.15442965924739838, "2011": 0.30486753582954407, "2028": 0.45932671427726746, "202... | 15928989 | Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis. It is strongly expressed in granulosa cells of ovarian follicles and in the corpus luteu... | Liver receptor homolog-1 is essential for pregnancy |
{"1011": 0.13670019805431366, "2000": 0.09406650811433792, "2002": 0.947819709777832, "2005": 0.1064341589808464, "2007": 0.11778303235769272, "2011": 0.23479416966438293, "2013": 0.3127557039260864, "2015": 0.4909018874168396, "2020": 0.10906458646059036, "2029": 0.16110190749168396, "2042": 0.07341018319129944, "2046... | 15945975 | Genetic reprogramming of somatic cells to a pluripotent state (induced pluripotent stem cells or iPSCs) by over-expression of specific genes has been accomplished using mouse and human cells. However, it is still unclear how similar human iPSCs are to human Embryonic Stem Cells (hESCs). Here, we describe the transcript... | Transcriptional Signature and Memory Retention of Human-Induced Pluripotent Stem Cells |
{"1009": 0.5261374711990356, "1011": 0.22548456490039825, "1015": 0.14179791510105133, "1016": 0.21530038118362427, "1018": 0.16359257698059082, "1022": 0.06246116757392883, "1023": 0.7809720039367676, "1039": 0.7818660736083984, "1050": 0.41195443272590637, "1055": 0.3423145115375519, "1060": 0.09938567131757736, "115... | 15946643 | Metastasis and chemoresistance in cancer are linked phenomena, but the molecular basis for this link is unknown. We uncovered a network of paracrine signals between carcinoma, myeloid, and endothelial cells that drives both processes in breast cancer. Cancer cells that overexpress CXCL1 and 2 by transcriptional hyperac... | A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis |
{"1014": 0.2478361576795578, "1040": 0.11168810725212097, "1041": 0.3519764244556427, "1052": 0.24554696679115295, "1058": 0.18492233753204346, "2004": 0.40220460295677185, "2005": 0.2837681770324707, "2006": 0.29328158497810364, "2030": 0.1685553640127182, "2044": 0.8400169610977173, "2076": 0.16276304423809052, "2079... | 15948830 | Postoperative vomiting (POV) remains one of the commonest causes of significant morbidity after tonsillectomy in children. A variety of prophylactic anti-emetic interventions have been reported, but there has only been a limited systematic review in this patient group. A systematic search was performed by using Cochran... | Prophylaxis of postoperative vomiting in children undergoing tonsillectomy: a systematic review and meta-analysis. |
{"1011": 0.08871890604496002, "1016": 0.21372433006763458, "1053": 0.010684899985790253, "1054": 0.7445381283760071, "1056": 0.45251765847206116, "1998": 0.05046287178993225, "2003": 0.13755162060260773, "2019": 0.2539152204990387, "2024": 0.02412080205976963, "2048": 0.669430673122406, "2054": 0.13414156436920166, "20... | 15953181 | Receiver operating characteristic (ROC) curves are used to describe and compare the performance of diagnostic technology and diagnostic algorithms. This paper refines the statistical comparison of the areas under two ROC curves derived from the same set of patients by taking into account the correlation between the are... | A method of comparing the areas under receiver operating characteristic curves derived from the same cases. |
{"1011": 0.053244512528181076, "1018": 0.29981520771980286, "1042": 0.00875066313892603, "1999": 0.056018441915512085, "2008": 0.03360854089260101, "2011": 0.5145297050476074, "2012": 0.14349138736724854, "2025": 0.0317181795835495, "2026": 0.7872136831283569, "2029": 0.1946154683828354, "2039": 0.2026219218969345, "20... | 15955172 | An outstanding biological question is why tissue regeneration in mammals is limited, whereas urodele amphibians and teleost fish regenerate major structures, largely by cell cycle reentry. Upon inactivation of Rb, proliferation of postmitotic urodele skeletal muscle is induced, whereas in mammalian muscle this mechanis... | Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. |
{"1011": 0.2089812457561493, "1017": 0.05694137513637543, "1038": 0.6734226942062378, "1039": 0.255429208278656, "1040": 0.09317722171545029, "1044": 0.1619328260421753, "1047": 0.4425300657749176, "1996": 0.5696102976799011, "2003": 0.3034266233444214, "2006": 0.20660123229026794, "2008": 0.11517547070980072, "2010": ... | 15960670 | The centromere is a chromatin region that serves as the spindle attachment point and directs accurate inheritance of eukaryotic chromosomes during cell divisions. However, the mechanism by which the centromere assembles and stabilizes at a specific genomic region is not clear. The de novo formation of a human/mammalian... | CENP-B Controls Centromere Formation Depending on the Chromatin Context |
{"1011": 0.06886265426874161, "1042": 0.4177590310573578, "1048": 0.4574742913246155, "1998": 0.3269403576850891, "2000": 0.14433705806732178, "2003": 0.35060185194015503, "2005": 0.056018441915512085, "2007": 0.11168810725212097, "2030": 0.06886265426874161, "2048": 0.07612881064414978, "2050": 1.292155385017395, "206... | 15966318 | We have developed three computer programs for comparisons of protein and DNA sequences. They can be used to search sequence data bases, evaluate similarity scores, and identify periodic structures based on local sequence similarity. The FASTA program is a more sensitive derivative of the FASTP program, which can be use... | Improved tools for biological sequence comparison. |
{"1017": 0.045809537172317505, "1041": 0.401551216840744, "1997": 0.04487626627087593, "2028": 0.0842406153678894, "2048": 0.23633737862110138, "2052": 0.03831886500120163, "2053": 0.03360854089260101, "2063": 0.055094651877880096, "2069": 0.47463157773017883, "2071": 0.175953671336174, "2093": 0.03925827145576477, "20... | 15968271 | OBJECTIVE Our objective is to estimate and compare the prevalence of selected adverse consequences associated with unmet need for assistance among a socioeconomically and medically vulnerable subgroup of the older adult population, those who are dually eligible for Medicare and Medicaid, with those eligible for Medicar... | The adverse consequences of unmet need among older persons living in the community: dual-eligible versus Medicare-only beneficiaries. |
{"1009": 0.41647201776504517, "1011": 0.030771657824516296, "1039": 0.47463157773017883, "1049": 0.6882523894309998, "2003": 0.5232481360435486, "2005": 0.1751343309879303, "2006": 0.036437395960092545, "2024": 0.0317181795835495, "2026": 0.2447827309370041, "2033": 1.3444138765335083, "2063": 0.2607102394104004, "2064... | 15969637 | UNLABELLED MesoRD is a tool for stochastic simulation of chemical reactions and diffusion. In particular, it is an implementation of the next subvolume method, which is an exact method to simulate the Markov process corresponding to the reaction-diffusion master equation. AVAILABILITY MesoRD is free software, written i... | Supplementary information: ‘MesoRD User’s Guide ’ and other |
{"1011": 0.03831886500120163, "1049": 0.6389714479446411, "1056": 1.2889312505722046, "2007": 0.46670228242874146, "2011": 0.20977331697940826, "2029": 0.1685553640127182, "2048": 0.2539152204990387, "2076": 0.08961215615272522, "2079": 0.0842406153678894, "2090": 0.15442965924739838, "2099": 0.8247235417366028, "2110"... | 15972906 | T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological syna... | Functional anatomy of T cell activation and synapse formation. |
{"1016": 0.4196864068508148, "1039": 0.6369074583053589, "1054": 0.9531047344207764, "2001": 0.007782140281051397, "2005": 0.0174254160374403, "2007": 0.20102575421333313, "2010": 0.6400018334388733, "2011": 0.22001366317272186, "2015": 0.12384103983640671, "2020": 0.0058422754518687725, "2029": 0.06977381557226181, "2... | 15975146 | The fungal pathogen, Cryptococcus neoformans, has been shown to undergo replicative aging. Old cells are characterized by advanced generational age and phenotypic changes that appear to mediate enhanced resistance to host and antifungal-based killing. As a consequence of this age-associated resilience, old cells accumu... | Modulation of Replicative Lifespan in Cryptococcus neoformans: Implications for Virulence |
{"1011": 0.34023189544677734, "1017": 0.06795065850019455, "1018": 0.45870962738990784, "1039": 0.8057082891464233, "1052": 0.7592713832855225, "1053": 0.8195732831954956, "1999": 0.010684899985790253, "2000": 0.026025565341114998, "2007": 0.13925230503082275, "2008": 0.176772341132164, "2011": 0.12642613053321838, "20... | 15981174 | To generate transgenic mice that express Cre-recombinase exclusively in the megakaryocytic lineage, we modified a mouse bacterial artificial chromosome (BAC) clone by homologous recombination and replaced the first exon of the platelet factor 4 (Pf4), also called CXCL4, with a codon-improved Cre cDNA. Several strains e... | Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. |
{"1011": 0.3547199070453644, "1015": 0.3339579105377197, "1016": 0.03266380727291107, "1039": 0.6624060273170471, "1041": 0.5080875158309937, "1052": 0.7692760229110718, "1059": 0.8583967685699463, "1996": 0.15359249711036682, "1998": 0.02412080205976963, "1999": 0.10555581003427505, "2005": 0.11430477350950241, "2007"... | 15983148 | Nervous system function requires proper development of two functional and morphological domains of neurons, axons and dendrites. Although both these domains are equally important for signal transmission, our understanding of dendrite development remains relatively poor. Here, we show that in C. elegans the Wnt ligand, ... | LIN-44/Wnt Directs Dendrite Outgrowth through LIN-17/Frizzled in C. elegans Neurons |
{"1007": 0.020300358533859253, "1017": 0.2145126610994339, "1043": 0.4145384132862091, "1057": 0.026976587250828743, "2000": 0.0029254043474793434, "2005": 0.2696990668773651, "2051": 0.007782140281051397, "2052": 0.25995752215385437, "2060": 0.2231435477733612, "2062": 0.04207121208310127, "2071": 0.10467668622732162,... | 15983982 | OBJECTIVES To describe the role patient expectations play in general practitioners (GPs) antibiotic prescribing for upper respiratory tract infections (URTI). METHODS Concurrent explanatory mixed methods approach using a cross-sectional survey and semistructured interviews. SETTINGS Primary care GPs in Australia. PARTI... | Why do general practitioners prescribe antibiotics for upper respiratory tract infections to meet patient expectations: a mixed methods study |
{"1014": 0.1358480453491211, "1016": 0.04487626627087593, "1998": 0.2689530849456787, "1999": 0.2622140049934387, "2007": 0.20977331697940826, "2018": 0.10467668622732162, "2026": 0.7276995778083801, "2031": 0.08244366943836212, "2048": 0.2247048318386078, "2086": 0.10993985831737518, "2090": 0.5255602598190308, "2094"... | 15984735 | OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic databases (PubMed, Embase, Cochrane Library) and reference lists of included studies an... | Migraine and cardiovascular disease: systematic review and meta-analysis. |
{"1020": 0.20102575421333313, "1054": 0.15275461971759796, "2005": 0.43244171142578125, "2007": 0.16690383851528168, "2029": 0.11168810725212097, "2034": 0.4425300657749176, "2045": 0.16607704758644104, "2060": 0.01934296265244484, "2064": 0.13071982562541962, "2069": 0.46608972549438477, "2076": 0.46117570996284485, "... | 15997009 | BACKGROUND Treatment regimens for active tuberculosis (TB) that are intermittent, or use rifampin during only the initial phase, offer practical advantages, but their efficacy has been questioned. We conducted a systematic review of treatment regimens for active TB, to assess the effect of duration and intermittency of... | Effect of Duration and Intermittency of Rifampin on Tuberculosis Treatment Outcomes: A Systematic Review and Meta-Analysis |
{"1014": 0.77198725938797, "1015": 0.18978065252304077, "1016": 0.03925827145576477, "1017": 0.09050461649894714, "1018": 0.04394211992621422, "1038": 0.40546512603759766, "1045": 0.14095009863376617, "1052": 0.2539152204990387, "1054": 0.40481385588645935, "1057": 0.07884006202220917, "1999": 0.31132611632347107, "200... | 16016673 | PURPOSE This study aims to provide a better set of DNA methylation markers in urine sediments for sensitive and specific detection of bladder cancer. EXPERIMENTAL DESIGN Fifty-nine tumor-associated genes were profiled in three bladder cancer cell lines, a small cohort of cancer biopsies and urine sediments by methylati... | A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer. |
{"1011": 0.2830325961112976, "1048": 0.4158279001712799, "1155": 0.8022117614746094, "1156": 0.6265231370925903, "1996": 0.04487626627087593, "1997": 0.2954642176628113, "1999": 0.12642613053321838, "2013": 0.32270604372024536, "2024": 0.21687394380569458, "2029": 0.01934296265244484, "2031": 0.24631060659885406, "2033... | 16056410 | BACKGROUND Microtubules are built from linear polymers of α-β tubulin dimers (protofilaments) that form a tubular quinary structure. Microtubules assembled from purified tubulin in vitro contain between 10 and 16 protofilaments; however, such structural polymorphisms are not found in cells. This discrepancy implies tha... | Posttranslational Acetylation of α-Tubulin Constrains Protofilament Number in Native Microtubules |
{"1011": 0.052318159490823746, "1044": 0.3339579105377197, "1999": 0.016465263441205025, "2003": 0.3916989266872406, "2005": 0.16359257698059082, "2007": 0.07341018319129944, "2029": 0.0752234235405922, "2030": 1.200646996498108, "2036": 0.045809537172317505, "2044": 0.14433705806732178, "2054": 0.27786844968795776, "2... | 16056514 | Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intravenous infusions of hypertonic sodium la... | A KEY ROLE FOR OREXIN IN PANIC ANXIETY |
{"2004": 0.4974553883075714, "2011": 0.24018502235412598, "2012": 0.48068851232528687, "2033": 0.08154398202896118, "2043": 0.083342544734478, "2064": 0.015504186972975731, "2075": 0.10993985831737518, "2076": 0.6808650493621826, "2079": 0.25995752215385437, "2090": 0.7845434546470642, "2096": 0.013579257763922215, "21... | 16057926 | Mechanical forces play important roles during tissue organization in developing animals. Many tissues are organized into adjacent, nonmixing groups of cells termed compartments. Boundaries between compartments display a straight morphology and are associated with signaling centers that are important for tissue growth a... | Local Increases in Mechanical Tension Shape Compartment Boundaries by Biasing Cell Intercalations |
{"1011": 0.2160874605178833, "1015": 0.7755908370018005, "1038": 0.08513788133859634, "1047": 0.6714286804199219, "1056": 0.8212929964065552, "1156": 0.43812891840934753, "1998": 0.007782140281051397, "2011": 0.3012613356113434, "2028": 0.41840189695358276, "2029": 0.14179791510105133, "2048": 0.22001366317272186, "205... | 16058322 | beta-Cell destruction in type 1 diabetes (T1D) is at least in part consequence of a 'dialog' between beta-cells and immune system. This dialog may be affected by the individual's genetic background. We presently evaluated whether modulation of MDA5 and PTPN2, two candidate genes for T1D, affects beta-cell responses to ... | MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA |
{"1042": 0.5712664127349854, "1050": 0.14095009863376617, "1056": 0.2145126610994339, "2003": 0.1332872211933136, "2005": 0.03360854089260101, "2011": 0.20739519596099854, "2026": 0.7827593088150024, "2058": 0.2018241584300995, "2076": 0.07159364968538284, "2078": 0.22626367211341858, "2079": 0.1358480453491211, "2109"... | 16066726 | Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by directing formation of granulomas, organized aggregates of macrophages and other immune cells. Loss of TNF signaling causes progression of tuberculosis in humans, and the increased mortality of Mycobacterium tuber... | Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. |
{"1011": 0.17431432008743286, "1013": 0.14349138736724854, "1057": 0.4267219603061676, "1998": 0.34370049834251404, "2004": 0.1485546976327896, "2006": 0.3560888469219208, "2007": 0.1602703034877777, "2011": 0.3464667797088623, "2029": 0.08782484382390976, "2033": 0.2830325961112976, "2038": 0.07793712615966797, "2049"... | 16086778 | The biological antagonism between Notch and Numb controls the proliferative/differentiative balance in development and homeostasis. Although altered Notch signaling has been linked to human diseases, including cancer, evidence for a substantial involvement of Notch in human tumors has remained elusive. Here, we show th... | Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis |
{"1011": 0.11168810725212097, "1040": 0.8813109993934631, "1052": 0.5290185213088989, "1996": 0.09050461649894714, "1999": 0.0842406153678894, "2004": 0.7665573358535767, "2007": 0.5063233375549316, "2008": 0.01934296265244484, "2012": 0.13414156436920166, "2029": 0.1905880719423294, "2043": 0.04113444685935974, "2057"... | 16090672 | Dynein at the cortex contributes to microtubule-based positioning processes such as spindle positioning during embryonic cell division and centrosome positioning during fibroblast migration. To investigate how cortical dynein interacts with microtubule ends to generate force and how this functional association impacts ... | Cortical Dynein Controls Microtubule Dynamics to Generate Pulling Forces that Position Microtubule Asters |
{"1011": 0.04953393340110779, "1014": 0.5805994272232056, "1026": 0.17840765416622162, "1038": 0.8247235417366028, "1044": 0.5805994272232056, "1050": 0.15777134895324707, "1052": 0.5045560002326965, "2012": 0.14349138736724854, "2029": 0.03831886500120163, "2034": 0.41065993905067444, "2047": 0.2607102394104004, "2073... | 16098747 | Evaluate known breast cancer risk factors in relation to breast density. We examined factors in relation to breast density in 144,018 New Hampshire (NH) women with at least one mammogram recorded in a statewide mammography registry. Mammographic breast density was measured by radiologists using the BI-RADS classificati... | Breast cancer risk factors in relation to breast density (United States) |
{"1997": 0.020300358533859253, "2001": 0.16690383851528168, "2010": 0.5461324453353882, "2011": 0.3381449282169342, "2034": 0.16359257698059082, "2037": 0.5607312321662903, "2040": 0.2247048318386078, "2047": 0.30989447236061096, "2049": 0.20977331697940826, "2059": 0.08871890604496002, "2064": 0.25995752215385437, "20... | 16108876 | Repression of competition within groups joins kin selection as the second major force in the history of life shaping the evolution of cooperation. When opportunities for competition against neighbors are limited within groups, individuals can increase their own success only by enhancing the efficiency and productivity ... | Perspective: repression of competition and the evolution of cooperation. |
{"1011": 0.176772341132164, "1017": 0.13925230503082275, "1040": 0.0842406153678894, "1052": 0.037378571927547455, "1056": 0.5295937061309814, "1999": 0.16690383851528168, "2003": 0.176772341132164, "2004": 0.14179791510105133, "2007": 0.37640097737312317, "2011": 0.18004031479358673, "2029": 0.1677299439907074, "2039"... | 16119973 | IBD is characterized by uncontrolled immune responses in inflamed mucosa, with dominance of IL-17-producing cells and deficiency of Treg cells. The aim of this study was to explore the effect and mechanisms of RA, the ligand of RARalpha, on immune responses in human and murine colitis. Colonic biopsies from patients wi... | Article |
{"1011": 0.10993985831737518, "1015": 0.03266380727291107, "1017": 0.41840189695358276, "1055": 0.18167030811309814, "1060": 0.5057345628738403, "1999": 0.10555581003427505, "2005": 0.04674193635582924, "2008": 0.08513788133859634, "2011": 0.10379679501056671, "2015": 0.3519764244556427, "2029": 0.2478361576795578, "20... | 16120395 | Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity. We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed in iron-replete conditions in the absence of the S. cerevisiae RNase III orth... | Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae. |
{"1011": 0.4349733293056488, "1040": 0.3554046154022217, "1041": 0.5557019114494324, "1043": 0.659380316734314, "1156": 0.6064908504486084, "1997": 0.05139094591140747, "1999": 0.1734936386346817, "2004": 0.16359257698059082, "2007": 0.16524957120418549, "2011": 0.022212404757738113, "2015": 0.7854343056678772, "2029":... | 16128711 | Adherens junctions (AJs) in epithelial cells are constantly turning over to modulate adhesion properties under various physiological and developmental contexts, but how such AJ dynamics are regulated during the apical-basal polarization of primary epithelia remains unclear. Here, we used new and genetically validated G... | Differential regulation of adherens junction dynamics during apical-basal polarization. |
{"1005": 0.34922540187835693, "1006": 0.46302130818367004, "1011": 0.45251765847206116, "1017": 0.7854343056678772, "1035": 0.026025565341114998, "1037": 0.5232481360435486, "1052": 0.4311734735965729, "1997": 0.043007105588912964, "2003": 0.306306391954422, "2004": 0.020300358533859253, "2005": 0.15023678541183472, "2... | 16167746 | mRNA polyadenylation is an essential step for the maturation of almost all eukaryotic mRNAs, and is tightly coupled with termination of transcription in defining the 3'-end of genes. Large numbers of human and mouse genes harbor alternative polyadenylation sites [poly(A) sites] that lead to mRNA variants containing dif... | Phylogenetic analysis of mRNA polyadenylation sites reveals a role of transposable elements in evolution of the 3′-end of genes |
{"1003": 0.11256109178066254, "1014": 0.1477125883102417, "1040": 0.034552380442619324, "1997": 0.08961215615272522, "2011": 0.06337817758321762, "2012": 0.4568560719490051, "2013": 0.34300774335861206, "2015": 0.06337817758321762, "2020": 0.09406650811433792, "2035": 0.23864774405956268, "2042": 0.08513788133859634, "... | 16172576 | BACKGROUND High genetic diversity at both inter- and intra-host level are hallmarks of RNA viruses due to the error-prone nature of their genome replication. Several groups have evaluated the extent of viral variability using different RNA virus deep sequencing methods. Although much of this effort has been dedicated t... | Inter- and Intra-Host Viral Diversity in a Large Seasonal DENV2 Outbreak |
{"1014": 0.3949938118457794, "1017": 0.2852376699447632, "1039": 0.1946154683828354, "1047": 0.23479416966438293, "1052": 0.17267228662967682, "2005": 0.06703783571720123, "2007": 0.0752234235405922, "2015": 0.1229778528213501, "2042": 0.24325250089168549, "2043": 0.0842406153678894, "2044": 0.7258110046386719, "2053":... | 16180601 | OBJECTIVE Serum soluble corin has been associated with stroke. However, whether it is associated with stroke prognosis has not yet been studied. Therefore, we aimed to study the association of serum soluble corin with risk of poor outcomes within 3 months after stroke. METHODS We followed 522 stroke patients for 3 mont... | Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke |
{"1011": 0.04674193635582924, "1014": 0.07250232994556427, "1022": 0.11691460013389587, "1038": 0.1510767638683319, "1039": 0.42161011695861816, "1041": 0.26296505331993103, "1043": 0.20022670924663544, "1044": 0.28155985474586487, "1045": 0.822151780128479, "1050": 0.5784112811088562, "1052": 0.15275461971759796, "200... | 16201748 | BACKGROUND Different molecular alterations have been described in endometrioid endometrial carcinoma (EECA). Among them the most frequently altered is loss of the PTEN protein, a tumor suppressor gene. The purpose of this study was to evaluate the expression pattern of PTEN gene in normal, hyperplastic and neoplastic e... | Altered PTEN expression; a diagnostic marker for differentiating normal, hyperplastic and neoplastic endometrium |
{"1003": 0.2763880789279938, "1019": 0.567397952079773, "1048": 0.7592713832855225, "1050": 0.401551216840744, "1997": 0.13670019805431366, "2013": 0.2493593990802765, "2020": 0.2741633653640747, "2022": 0.19622190296649933, "2035": 0.00875066313892603, "2045": 0.14179791510105133, "2051": 0.22859740257263184, "2073": ... | 16204011 | BACKGROUND Despite recent achievements to reduce child mortality, neonatal deaths continue to remain high, accounting for 41% of all deaths in children under five years of age worldwide, of which over 90% occur in low- and middle-income countries (LMICs). Infections are a leading cause of death and limitations in care ... | Care Seeking for Neonatal Illness in Low- and Middle-Income Countries: A Systematic Review |
{"1011": 0.0797421783208847, "1015": 0.24325250089168549, "1022": 0.21530038118362427, "1043": 0.8332487344741821, "1047": 0.02792670577764511, "1052": 0.6950984001159668, "1054": 0.020300358533859253, "1055": 0.4788752794265747, "1999": 0.018384648486971855, "2004": 0.02792670577764511, "2005": 0.07159364968538284, "2... | 16208091 | Incorporation of GluR1-containing AMPA receptors into synapses is essential to several forms of neural plasticity, including long-term potentiation (LTP). Numerous signaling pathways that trigger this process have been identified, but the direct modifications of GluR1 that control its incorporation into synapses are un... | Synaptic Incorporation of AMPA Receptors during LTP Is Controlled by a PKC Phosphorylation Site on GluR1 |
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