spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1009": 0.1602703034877777, "1011": 0.1602703034877777, "1019": 0.04207121208310127, "1038": 1.2035820484161377, "1043": 0.26146242022514343, "1055": 0.2696990668773651, "2002": 0.6828403472900391, "2003": 0.07068414986133575, "2005": 0.06886265426874161, "2008": 0.04767346754670143, "2011": 0.12814582884311676, "2029... | 16217855 | The product of the gene mutated in Bloom's syndrome, BLM, is a 3′–5′ DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand separation activity, BLM catalyzes both the disruption of non-B-form DNA, such as G-quadruplexes, and the branch migration of Holliday junctions. Here... | The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA |
{"1013": 0.03831886500120163, "1017": 0.0770333781838417, "1020": 0.053244512528181076, "1023": 0.02792670577764511, "1039": 0.2667117714881897, "1041": 0.42735910415649414, "1043": 0.23092569410800934, "1056": 0.3353555500507355, "1057": 0.2918238639831543, "1997": 0.23015019297599792, "2015": 0.06337817758321762, "20... | 16232581 | We develop a reversible jump Markov chain Monte Carlo approach to estimating the posterior distribution of phylogenies based on aligned DNA/RNA sequences under several hierarchical evolutionary models. Using a proper, yet nontruncated and uninformative prior, we demonstrate the advantages of the Bayesian approach to hy... | Bayesian selection of continuous-time Markov chain evolutionary models. |
{"1997": 0.0317181795835495, "1998": 0.20580662786960602, "2043": 0.05970508232712746, "2045": 0.512191891670227, "2048": 0.3262358605861664, "2057": 0.2160874605178833, "2058": 0.04487626627087593, "2062": 0.2089812457561493, "2064": 0.009718249551951885, "2070": 0.14518201351165771, "2079": 0.1212492436170578, "2085"... | 16233471 | The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will con... | The intersection between aging and cardiovascular disease. |
{"1019": 0.1994270235300064, "1040": 0.29473719000816345, "1052": 0.11951763927936554, "1999": 0.29255300760269165, "2011": 0.29255300760269165, "2028": 0.23556606471538544, "2029": 0.015504186972975731, "2051": 0.3956514894962311, "2064": 0.29255300760269165, "2073": 0.15610189735889435, "2079": 0.0842406153678894, "2... | 16237005 | Proper execution of transcriptional programs is a key requirement of gene expression regulation, demanding accurate control of timing and amplitude. How precisely the transcription machinery fulfills this task is not known. Using an in situ hybridization approach that detects single mRNA molecules, we measured mRNA abu... | Single-RNA counting reveals alternative modes of gene expression in yeast |
{"1011": 0.1693800985813141, "1056": 0.043007105588912964, "1996": 0.06429435312747955, "1997": 0.10555581003427505, "1999": 0.151916041970253, "2005": 0.02792670577764511, "2011": 0.3485364317893982, "2012": 0.15526613593101501, "2029": 0.23633737862110138, "2044": 0.2990913391113281, "2046": 0.06520967930555344, "205... | 16242975 | In mammalian mitochondria, 22 species of tRNAs encoded in mitochondrial DNA play crucial roles in the translation of 13 essential subunits of the respiratory chain complexes involved in oxidative phosphorylation. Following transcription, mitochondrial tRNAs are modified by nuclear-encoded tRNA-modifying enzymes. These ... | A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs |
{"1017": 0.04207121208310127, "1018": 0.1994270235300064, "1020": 0.20501139760017395, "1022": 0.10555581003427505, "1038": 0.7426811456680298, "1042": 0.6466736793518066, "1044": 0.06612417846918106, "1048": 0.0752234235405922, "1052": 0.13157635927200317, "1998": 0.30989447236061096, "2005": 0.18654440343379974, "200... | 16252863 | The list of preventable and reversible risk factors for atherosclerotic cardiovascular disease continues to grow. Cigarette smoking, high blood pressure, physical inactivity, elevated cholesterol, underlying lipoprotein abnormalities, lipoprotein(a), diabetes, overweight, male gender, and age are well-established risk ... | Preventing coronary heart disease: B vitamins and homocysteine. |
{"1013": 0.19381128251552582, "1026": 0.08603433519601822, "1040": 1.1894142627716064, "1044": 0.26296505331993103, "1052": 0.13243216276168823, "2001": 0.07159364968538284, "2004": 0.49982786178588867, "2005": 0.23402166366577148, "2012": 0.12728634476661682, "2022": 0.10555581003427505, "2043": 0.007782140281051397, ... | 16256507 | CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known. Serum 25-hydroxyvitamin D is the generally accepted indicator of vitamin D status, but no universal reference level has been reached. OBJECTIVE To investigate the relativ... | Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. |
{"1009": 0.29036402702331543, "1011": 0.12814582884311676, "1015": 0.34508460760116577, "1016": 0.21765978634357452, "1039": 0.4879087805747986, "1040": 0.22782009840011597, "1045": 0.6420594453811646, "1998": 0.2800849378108978, "2004": 0.3027053773403168, "2013": 0.026025565341114998, "2014": 0.7907629609107971, "201... | 16267205 | Sex differences in longevity and aging are seen throughout the animal kingdom. These are likely to result, in part, from sex differences in endocrinology. In the nematode Caenorhabditis elegans, males are the longer-lived sex. Here we explore the possibility that sex differences in insulin/insulin-like growth factor 1 ... | Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegans. |
{"1011": 0.5450005531311035, "1016": 0.15526613593101501, "1017": 0.6358738541603088, "1044": 1.1598494052886963, "1048": 0.058784693479537964, "1049": 0.8973627090454102, "1050": 0.35677260160446167, "1052": 0.1401015669107437, "1996": 0.040196798741817474, "1997": 0.22548456490039825, "1999": 0.1221139207482338, "200... | 16270577 | H2-M3 is a class Ib MHC molecule of the mouse with a 10(4)-fold preference for binding N-formylated peptides. To elucidate the basis of this unusual specificity, we expressed and crystallized a soluble form of M3 with a formylated nonamer peptide, fMYFINILTL, and determined the structure by X-ray crystallography. M3, r... | Nonclassical binding of formylated peptide in crystal structure of the MHC class lb molecule H2-M3 |
{"1011": 0.11517547070980072, "1050": 0.3012613356113434, "1052": 0.4356052577495575, "1056": 0.5290185213088989, "1996": 0.11081436276435852, "1999": 0.7067264318466187, "2003": 0.22157983481884003, "2008": 0.08782484382390976, "2011": 0.26296505331993103, "2015": 0.21372433006763458, "2024": 0.42353010177612305, "202... | 16280642 | Podosomes (also termed invadopodia in cancer cells) are actin-rich adhesion structures with matrix degradation activity that develop in various cell types. Despite their significant physiological importance, the molecular mechanism of podosome formation is largely unknown. In this study, we investigated the molecular m... | Sequential signals toward podosome formation in NIH-src cells |
{"1009": 0.14939609169960022, "1011": 0.24018502235412598, "1043": 1.057410478591919, "1999": 0.22859740257263184, "2007": 0.23015019297599792, "2008": 0.030771657824516296, "2011": 0.23864774405956268, "2020": 0.17431432008743286, "2024": 0.09850110858678818, "2029": 0.37640097737312317, "2035": 0.29109421372413635, "... | 16284655 | Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous and species-selective properties of human glia, we engrafted human glial progenitor cells (GPCs) into neonatal immunodeficient mice.... | Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. |
{"1011": 0.24631060659885406, "1018": 0.5010119676589966, "1039": 0.5936289429664612, "1047": 0.736154317855835, "2000": 0.17020416259765625, "2005": 0.1011524572968483, "2007": 0.07341018319129944, "2008": 0.03266380727291107, "2025": 0.2394166737794876, "2026": 1.001607894897461, "2029": 0.4132472574710846, "2038": 0... | 16287725 | Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process. However, unlike in mouse, OCT4 has not been replaced successfully during rep... | Reprogramming of human fibroblasts to pluripotency with lineage specifiers. |
{"1011": 0.09495500475168228, "1040": 0.14433705806732178, "1041": 0.11256109178066254, "1043": 0.4752389192581177, "1996": 0.13670019805431366, "1999": 0.037378571927547455, "2008": 0.06795065850019455, "2011": 0.05970508232712746, "2024": 0.04767346754670143, "2029": 0.24325250089168549, "2076": 0.17759032547473907, ... | 16319097 | Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events. We discuss the well-studied clathrin-me... | Mechanisms of endocytosis. |
{"1014": 0.28450319170951843, "1019": 0.06246116757392883, "1023": 0.05139094591140747, "1052": 0.29619070887565613, "1061": 0.3177432417869568, "1081": 0.018384648486971855, "2020": 0.06520967930555344, "2076": 0.025073638185858727, "2090": 0.20102575421333313, "2106": 0.014542185701429844, "2109": 0.19220098853111267... | 16322674 | BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual participant data from published and unpublished studies to obtain more precise estimates of the magnitude an... | Birth Size and Breast Cancer Risk: Re-analysis of Individual Participant Data from 32 Studies |
{"1011": 0.21372433006763458, "1019": 0.7647408246994019, "1038": 0.35745587944984436, "1043": 0.4158279001712799, "1048": 0.6102113127708435, "1052": 0.10026945173740387, "2004": 0.176772341132164, "2008": 0.0009760859538801014, "2011": 0.2089812457561493, "2029": 0.3683255612850189, "2039": 0.12986256182193756, "2051... | 16346504 | BACKGROUND Growth arrest-specific 5 (GAS5) was reported to be implicated and aberrantly express in multiple cancers. However, the expression and mechanism of action of GAS5 were largely poor understood in endometrial carcinoma. RESULTS According to the result of real-time reverse-transcriptase polymerase chain reaction... | LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells |
{"1017": 0.12384103983640671, "1041": 0.38374659419059753, "1155": 0.5232481360435486, "1156": 0.45437926054000854, "1999": 0.08154398202896118, "2003": 0.055094651877880096, "2005": 0.17759032547473907, "2011": 0.052318159490823746, "2015": 0.5718178153038025, "2029": 0.07159364968538284, "2033": 0.4145384132862091, "... | 16355392 | Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. Here we show that induction of urokinase receptor (uPAR) signaling in podocytes leads to foot proces... | Modification of kidney barrier function by the urokinase receptor |
{"1011": 0.10467668622732162, "1038": 0.6754127144813538, "1999": 0.0354953333735466, "2005": 0.05694137513637543, "2006": 0.40546512603759766, "2007": 0.12556517124176025, "2008": 0.013579257763922215, "2011": 0.0058422754518687725, "2026": 0.5838727951049805, "2029": 0.12986256182193756, "2037": 0.02792670577764511, ... | 16361581 | Notch receptors expressed on hematopoietic stem cells interact with their ligands on bone marrow stromal cells and thereby control cell fate decisions and survival. We recently demonstrated that Notch signaling is involved in proliferation and survival of B cell-derived tumor cells of classic Hodgkin disease and descri... | Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. |
{"1011": 0.18492233753204346, "1043": 0.7333439588546753, "1052": 0.083342544734478, "1999": 0.020300358533859253, "2004": 0.34508460760116577, "2007": 0.22392450273036957, "2008": 0.083342544734478, "2015": 0.10555581003427505, "2029": 0.2749055027961731, "2033": 0.5562619566917419, "2050": 0.21372433006763458, "2062"... | 16364639 | By analyzing gene expression data in glioblastoma in combination with matched microRNA profiles, we have uncovered a posttranscriptional regulation layer of surprising magnitude, comprising more than 248,000 microRNA (miR)-mediated interactions. These include ∼7,000 genes whose transcripts act as miR "sponges" and 148 ... | An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma |
{"1011": 0.030771657824516296, "1039": 0.27786844968795776, "1043": 0.5696102976799011, "1047": 0.28082266449928284, "2000": 0.1221139207482338, "2005": 0.10906458646059036, "2015": 0.2749055027961731, "2026": 0.8845420479774475, "2029": 0.10993985831737518, "2046": 0.5523349046707153, "2061": 0.9739698171615601, "2064... | 16375102 | The simple yet powerful technique of induced pluripotency may eventually supply a wide range of differentiated cells for cell therapy and drug development. However, making the appropriate cells via induced pluripotent stem cells (iPSCs) requires reprogramming of somatic cells and subsequent redifferentiation. Given how... | Direct reprogramming of mouse fibroblasts to neural progenitors. |
{"1011": 0.23864774405956268, "1016": 0.8813109993934631, "1052": 0.10203468054533005, "1156": 0.7028654217720032, "1996": 0.15526613593101501, "2011": 0.27044451236724854, "2029": 0.02792670577764511, "2038": 0.07341018319129944, "2048": 0.5584990978240967, "2063": 0.6744182109832764, "2109": 0.3485364317893982, "2117... | 16389141 | Dysfunction of the pancreatic beta cell is an important defect in the pathogenesis of type 2 diabetes, although its exact relationship to the insulin resistance is unclear. To determine whether insulin signaling has a functional role in the beta cell we have used the Cre-loxP system to specifically inactivate the insul... | Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes |
{"1014": 0.15777134895324707, "1019": 0.3485364317893982, "1023": 0.08603433519601822, "2001": 0.10291612148284912, "2002": 0.1930064558982849, "2004": 0.08603433519601822, "2018": 0.3077431619167328, "2020": 0.24248650670051575, "2022": 0.15526613593101501, "2043": 0.1619328260421753, "2044": 0.0842406153678894, "2051... | 16390264 | OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by socioeconomic circumstances, age, sex, and year of admission for colorectal, breast, and lung cancer. DESIGN Repeated cross sectional study with data from individual patients, 1 Apr... | Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics |
{"1043": 0.15777134895324707, "1044": 0.13925230503082275, "2003": 0.2719337046146393, "2005": 0.06795065850019455, "2010": 0.4145384132862091, "2015": 0.18654440343379974, "2073": 0.3676496744155884, "2083": 0.7436100244522095, "2109": 0.1685553640127182, "2116": 0.06612417846918106, "2128": 0.4568560719490051, "2129"... | 16398049 | Genomes are arranged non-randomly in the 3D space of the cell nucleus. Here, we have developed HIPMap, a high-precision, high-throughput, automated fluorescent in situ hybridization imaging pipeline, for mapping of the spatial location of genome regions at large scale. High-throughput imaging position mapping (HIPMap) ... | Identification of Gene Positioning Factors Using High-Throughput Imaging Mapping |
{"1006": 0.052318159490823746, "1009": 0.5707147121429443, "1011": 0.2501201331615448, "1016": 0.24859806895256042, "1043": 0.5784112811088562, "1044": 0.10379679501056671, "1996": 0.1384023278951645, "2006": 0.0797421783208847, "2011": 0.2652147710323334, "2012": 0.2539152204990387, "2029": 0.18167030811309814, "2039"... | 16398827 | Afferent activity can induce fast, feed-forward changes in synaptic efficacy that are synapse specific. Using combined electrophysiology, caged molecule photolysis, and Ca(2+) imaging, we describe a plasticity in which the recruitment of astrocytes in response to afferent activity causes a fast and feed-forward, yet di... | Astrocyte-Mediated Distributed Plasticity at Hypothalamic Glutamate Synapses |
{"1014": 0.38374659419059753, "1023": 0.05694137513637543, "1040": 0.0842406153678894, "1997": 0.1011524572968483, "2000": 0.03831886500120163, "2011": 0.07612881064414978, "2062": 0.27934664487838745, "2086": 0.3956514894962311, "2090": 0.18411032855510712, "2091": 0.034552380442619324, "2095": 0.24018502235412598, "2... | 16422880 | CONTEXT Many smokers are unable or unwilling to completely quit smoking. A proposed means of harm reduction is to reduce the number of cigarettes smoked per day. However, it is not clear whether this strategy decreases the risk for tobacco-related diseases. OBJECTIVE To assess the effects of smoking reduction on lung c... | Effect of smoking reduction on lung cancer risk. |
{"1015": 0.1510767638683319, "1017": 0.3995884954929352, "1021": 0.16442140936851501, "1038": 0.9271688461303711, "1049": 0.14433705806732178, "1156": 0.06977381557226181, "2005": 0.056018441915512085, "2012": 0.27712854743003845, "2019": 0.20102575421333313, "2022": 0.4794800877571106, "2042": 0.2667117714881897, "207... | 16427454 | Three macromolecular crystallography (MX) beamlines at the Helmholtz-Zentrum Berlin (HZB) are available for the regional, national and international structural biology user community. The state-of-the-art synchrotron beamlines for MX BL14.1, BL14.2 and BL14.3 are located within the low-β section of the BESSY II electro... | Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin |
{"1011": 0.2990913391113281, "1017": 0.19622190296649933, "1042": 0.10993985831737518, "1043": 0.05694137513637543, "1049": 0.5278670787811279, "1060": 1.0512858629226685, "2000": 0.056018441915512085, "2003": 0.3870677351951599, "2005": 0.11081436276435852, "2038": 0.1693800985813141, "2042": 0.015504186972975731, "20... | 16461149 | Macromolecular X-ray crystallography is routinely applied to understand biological processes at a molecular level. However, significant time and effort are still required to solve and complete many of these structures because of the need for manual interpretation of complex numerical data using many software packages a... | PHENIX: a comprehensive Python-based system for macromolecular structure solution |
{"1005": 0.3910386264324188, "1011": 0.38574060797691345, "1017": 1.1537069082260132, "1019": 0.3339579105377197, "1037": 0.0317181795835495, "1039": 0.03360854089260101, "1043": 0.36697331070899963, "1055": 0.06886265426874161, "1996": 0.20501139760017395, "2003": 0.0317181795835495, "2005": 0.22626367211341858, "2011... | 16465895 | A 3' overhang is critical for the protection and maintenance of mammalian telomeres, but its synthesis must be regulated to avoid excessive resection of the 5' end, which could cause telomere shortening. How this balance is achieved in mammals has not been resolved. Here, we determine the mechanism for 3' overhang synt... | Telomeric 3′ Overhangs Derive from Resection by Exo1 and Apollo and Fill-In by POT1b-Associated CST |
{"1011": 0.25694093108177185, "1018": 0.4518963396549225, "1021": 0.056018441915512085, "1043": 1.0409941673278809, "1049": 0.1602703034877777, "1052": 0.12728634476661682, "2000": 0.1332872211933136, "2011": 0.255429208278656, "2012": 0.2990913391113281, "2015": 0.42926809191703796, "2029": 0.2561853528022766, "2064":... | 16472469 | G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously shown that HR facil... | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds |
{"1011": 0.03831886500120163, "1020": 0.45870962738990784, "1044": 0.32341301441192627, "1048": 0.04207121208310127, "1081": 0.609149694442749, "1155": 0.49864232540130615, "1999": 0.1229778528213501, "2011": 0.2539152204990387, "2012": 0.28743788599967957, "2029": 0.33953672647476196, "2039": 0.46363574266433716, "204... | 16488405 | Physical activity induces a subclinical inflammatory response, mediated in part by leukocytes, and manifested by elevated concentrations of circulating proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α). However, the source of the cytokines that appear during exercise re... | Downloaded from |
{"1011": 0.04113444685935974, "1016": 0.3588210940361023, "1047": 1.0264055728912354, "1054": 0.3850763738155365, "1056": 0.48430517315864563, "1996": 0.09050461649894714, "1999": 0.004870930220931768, "2003": 0.02887592278420925, "2006": 0.35950297117233276, "2015": 0.3241194784641266, "2024": 0.18248429894447327, "20... | 16494316 | Receptor tyrosine kinases are involved in regulation of key processes in endothelial biology, including proliferation, migration, and angiogenesis. It is now generally accepted that receptor tyrosine kinase signaling occurs intracellularly and on the plasma membrane, although many important details remain to be worked ... | Receptor tyrosine kinases endocytosis in endothelium: biology and signaling. |
{"1997": 0.23556606471538544, "1998": 0.029824240133166313, "1999": 0.058784693479537964, "2001": 0.00875066313892603, "2028": 0.10467668622732162, "2041": 0.14686977863311768, "2052": 0.18248429894447327, "2071": 0.33115679025650024, "2076": 0.10555581003427505, "2077": 0.036437395960092545, "2087": 0.0495339334011077... | 16495649 | OBJECTIVES To determine the incidence and clinical importance of errors in the preparation and administration of intravenous drugs and the stages of the process in which errors occur. DESIGN Prospective ethnographic study using disguised observation. PARTICIPANTS Nurses who prepared and administered intravenous drugs. ... | Ethnographic study of incidence and severity of intravenous drug errors. |
{"1011": 0.012615402229130268, "1038": 0.2689530849456787, "1041": 0.19381128251552582, "1054": 1.1864371299743652, "2003": 0.33605360984802246, "2009": 0.319873183965683, "2035": 0.6492279767990112, "2050": 1.034767985343933, "2105": 0.2637155055999756, "2109": 0.18492233753204346, "2129": 0.16359257698059082, "2224":... | 16510361 | This article describes a R package Boruta, implementing a novel feature selection algorithm for finding emph{all relevant variables}. The algorithm is designed as a wrapper around a Random Forest classification algorithm. It iteratively removes the features which are proved by a statistical test to be less relevant tha... | Feature Selection with the Boruta Package |
{"1011": 0.3683255612850189, "1020": 0.1751343309879303, "1044": 0.3877306580543518, "1045": 0.0009760859538801014, "1047": 0.4831010699272156, "1048": 0.18492233753204346, "1052": 0.020300358533859253, "1054": 0.47827014327049255, "1055": 0.6598852276802063, "1059": 0.619189441204071, "2003": 0.1064341589808464, "2007... | 16511863 | BACKGROUND Although numerous signaling pathways are known to be activated in experimental cardiac hypertrophy, the molecular basis of the hypertrophic response inherent in human heart diseases remains largely unknown. Integrin-linked kinase (ILK) is a multifunctional protein kinase that physically links beta-integrins ... | Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. |
{"1011": 0.15442965924739838, "1015": 0.0174254160374403, "1016": 1.0855059623718262, "1022": 0.28743788599967957, "1043": 0.6022219061851501, "1044": 0.09584271162748337, "1051": 0.040196798741817474, "1999": 0.05417001247406006, "2007": 0.04394211992621422, "2013": 0.22626367211341858, "2020": 0.1384023278951645, "20... | 16527698 | To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the possible mechanisms involved, we studied several functional and molecular properties of islets isolated from the pancreata of 13 type 2 diabetic and 13 matched nondiabetic cadaveric organ donors. Glucose-stimulated insulin ... | Functional and molecular defects of pancreatic islets in human type 2 diabetes. |
{"1011": 0.020300358533859253, "1014": 0.3241194784641266, "1039": 0.5290185213088989, "1052": 0.13670019805431366, "2005": 0.1401015669107437, "2011": 0.056018441915512085, "2020": 0.11604541540145874, "2034": 0.21135559678077698, "2047": 0.23710809648036957, "2057": 0.14939609169960022, "2063": 0.1011524572968483, "2... | 16532419 | BACKGROUND Carbon nanotubes (CNT) hold great promise to create new and better products for commercial and biomedical applications, but their long-term adverse health effects are a major concern. The objective of this study was to address human lung cancer risks associated with chronic pulmonary exposure to single-walle... | Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes |
{"1011": 0.26146242022514343, "1018": 0.35745587944984436, "1039": 0.3409265875816345, "1041": 0.2531573474407196, "1047": 0.6853039860725403, "2007": 0.18654440343379974, "2008": 0.05970508232712746, "2011": 0.23247487843036652, "2015": 1.0492360591888428, "2026": 0.6902132034301758, "2029": 0.3012613356113434, "2035"... | 16541762 | We compared two genetically highly defined transgenic systems to identify parameters affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the level and stoichiometry of reprogramming factors during the reprogramming process strongly influence the resulting pluripotency of iPS ce... | Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. |
{"1011": 0.0913962796330452, "1015": 0.22782009840011597, "1020": 0.2652147710323334, "1023": 0.3897167444229126, "1039": 0.3248254358768463, "1042": 0.2741633653640747, "1043": 0.6348392367362976, "1044": 0.5562619566917419, "1050": 0.7389566898345947, "1164": 0.1401015669107437, "1999": 0.20580662786960602, "2001": 0... | 16546131 | Hydroxyurea is a potent teratogen; free radical scavengers or antioxidants reduce its teratogenicity. Activator Protein-1 (AP-1) and NF-kappaB are redox-sensitive transcription factors with important roles in normal development and the stress response. This study was designed to determine if exposure to teratogenic dos... | Activator protein-1 (AP-1) DNA binding activity is induced by hydroxyurea in organogenesis stage mouse embryos |
{"1011": 0.3995884954929352, "1015": 0.17759032547473907, "1020": 1.076228141784668, "1038": 0.9958525896072388, "1039": 0.3601844012737274, "1048": 0.5596157908439636, "1052": 0.22392450273036957, "2011": 0.3622259199619293, "2012": 0.1718502640724182, "2026": 0.77198725938797, "2029": 0.22548456490039825, "2048": 0.0... | 16550075 | BCL-6, a transcriptional repressor frequently translocated in lymphomas, regulates germinal center B cell differentiation and inflammation. DNA microarray screening identified genes repressed by BCL-6, including many lymphocyte activation genes, suggesting that BCL-6 modulates B cell receptor signals. BCL-6 repression ... | BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. |
{"1041": 0.17922431230545044, "1996": 0.021256839856505394, "2004": 0.18816383183002472, "2011": 0.3141832649707794, "2013": 0.42096930742263794, "2015": 0.2822965085506439, "2029": 0.040196798741817474, "2037": 0.3601844012737274, "2043": 0.07793712615966797, "2046": 0.5255602598190308, "2047": 0.5718178153038025, "20... | 16557565 | Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such as lateral roots, leaves, and flowers during postembryonic development. Organ primordia develop from founder cell populations into organs by coord... | Local, Efflux-Dependent Auxin Gradients as a Common Module for Plant Organ Formation |
{"1011": 0.15023678541183472, "1037": 0.018384648486971855, "1040": 0.5651806592941284, "1050": 0.39893341064453125, "1996": 0.04207121208310127, "1997": 0.0606246218085289, "2012": 0.03925827145576477, "2026": 0.9842413663864136, "2046": 0.11081436276435852, "2049": 0.38374659419059753, "2058": 0.17759032547473907, "2... | 16562534 | The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we discovered mutations in Drosophila mical, a conserved gene encoding a multi-domain... | Drosophila MICAL regulates myofilament organization and synaptic structure |
{"1015": 0.952351450920105, "1038": 0.5168620347976685, "1044": 0.3381449282169342, "1045": 0.2719337046146393, "1056": 0.8989537954330444, "1156": 0.890972912311554, "2003": 0.04860413447022438, "2007": 0.13499516248703003, "2011": 0.23092569410800934, "2013": 0.3127557039260864, "2020": 0.12986256182193756, "2028": 0... | 16572581 | Type 1 diabetes (T1D) is characterized by the destruction of the insulin-producing β-cells of pancreatic islets. Genetic and environmental factors both contribute to T1D development. Viral infection with enteroviruses is a suspected trigger for T1D, but a causal role remains unproven and controversial. Studies in anima... | Viral Infection of Engrafted Human Islets Leads to Diabetes |
{"1011": 0.417115718126297, "1017": 0.013579257763922215, "1018": 0.055094651877880096, "1042": 0.4770587682723999, "1044": 0.055094651877880096, "1052": 0.3547199070453644, "1054": 0.6950984001159668, "1056": 0.503966212272644, "2004": 0.11951763927936554, "2010": 0.5651806592941284, "2029": 0.1619328260421753, "2038"... | 16605494 | BACKGROUND Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel. One possible explanation is that successful treatment strategy may require simultaneous targeting of more than one molecule of pathway. A new therapeutic approach t... | MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington’s Disease-Related Mechanisms |
{"1039": 0.2696990668773651, "2000": 0.2674594223499298, "2003": 0.11517547070980072, "2054": 0.05786345899105072, "2078": 0.2394166737794876, "2079": 0.12642613053321838, "2109": 0.3163207769393921, "2166": 0.40351006388664246, "2224": 0.15275461971759796, "2241": 1.0101795196533203, "2278": 0.19220098853111267, "2323... | 16625620 | To deliver optimal patient care, evidence-based care is advocated and research is needed to support health care staff of all disciplines in deciding which options to use in their daily practice. Due to the increasing complexity of cardiac care across the life span of patients combined with the increasing opportunities ... | Research in cardiovascular care: a position statement of the Council on Cardiovascular Nursing and Allied Professionals of the European Society of Cardiology. |
{"1011": 0.1873544454574585, "1015": 0.37371641397476196, "1016": 0.1685553640127182, "1017": 0.0913962796330452, "1038": 0.30989447236061096, "1043": 0.13243216276168823, "1044": 0.9115922451019287, "1051": 0.17840765416622162, "2002": 0.319873183965683, "2007": 0.36494144797325134, "2010": 1.2140778303146362, "2012":... | 16626264 | Histone variants help specialize chromatin regions; however, their impact on transcriptional regulation is largely unknown. Here, we determined the genome-wide localization and dynamics of Htz1, the yeast histone H2A variant. Htz1 localizes to hundreds of repressed/basal Pol II promoters and prefers TATA-less promoters... | Genome-Wide Dynamics of Htz1, a Histone H2A Variant that Poises Repressed/Basal Promoters for Activation through Histone Loss |
{"1040": 0.6476961374282837, "1999": 0.007782140281051397, "2011": 0.11517547070980072, "2013": 0.4151833653450012, "2062": 0.1332872211933136, "2064": 0.15860503911972046, "2071": 0.11691460013389587, "2073": 0.03831886500120163, "2079": 0.19541899859905243, "2080": 0.02412080205976963, "2089": 0.04953393340110779, "2... | 16626846 | Crude oils can be major contaminants of the marine ecosystem and microorganisms play a significant role in the degradation of its main constituents. To increase our understanding of the microbial hydrocarbon degradation process in the marine ecosystem, we collected crude oil from an active seep area located in the Sant... | Metagenomic analysis of microbial consortium from natural crude oil that seeps into the marine ecosystem offshore Southern California |
{"1011": 0.10203468054533005, "1018": 0.1734936386346817, "1021": 0.5707147121429443, "1052": 0.6872705817222595, "1999": 0.03831886500120163, "2007": 0.03360854089260101, "2008": 0.006812678650021553, "2011": 0.3027053773403168, "2029": 0.2969166338443756, "2043": 0.15359249711036682, "2050": 0.5404602885246277, "2058... | 16627684 | Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16(Ink4a). We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that... | Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16Ink4a and p19Arf Expression |
{"2011": 0.12728634476661682, "2015": 0.6808650493621826, "2029": 0.010684899985790253, "2037": 0.07159364968538284, "2041": 0.09938567131757736, "2046": 0.18654440343379974, "2058": 0.020300358533859253, "2061": 0.9591107368469238, "2075": 1.0229004621505737, "2076": 0.0317181795835495, "2079": 0.09672962874174118, "2... | 16630060 | Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical sign of aging in mammals, is caused by the incomplete maintenance of melanocyte stem cells (MSCs) with age. Here, we report that irreparable DNA damage, as caused ... | Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation |
{"1011": 0.22782009840011597, "1018": 0.09406650811433792, "1040": 0.029824240133166313, "1041": 0.17020416259765625, "2007": 0.1994270235300064, "2011": 0.016465263441205025, "2029": 0.10818854719400406, "2051": 0.3554046154022217, "2076": 0.42225050926208496, "2099": 0.6420594453811646, "2102": 0.4709797203540802, "2... | 16630996 | To identify predictive molecular markers for gemcitabine resistance, we investigated changes in the expression of four genes associated with gemcitabine transport and metabolism during the development of acquired gemcitabine resistance of pancreatic cancer cell lines. The expression levels of human equilibrative nucleo... | Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells |
{"1996": 0.1477125883102417, "2004": 0.05970508232712746, "2005": 0.1602703034877777, "2006": 0.2231435477733612, "2011": 0.037378571927547455, "2012": 0.8152611255645752, "2029": 0.08064348995685577, "2034": 0.0058422754518687725, "2037": 0.026025565341114998, "2043": 0.021256839856505394, "2044": 0.5968599319458008, ... | 16644043 | Telomeres protect chromosome ends from being detected as lesions and from triggering DNA damage checkpoints. Paradoxically, telomere function depends on checkpoint proteins such as ATM and ATR, but a molecular model explaining this seemingly contradictory relationship has been missing so far. Here we show that the DNA ... | The DNA Damage Machinery and Homologous Recombination Pathway Act Consecutively to Protect Human Telomeres |
{"1009": 0.7746911644935608, "1011": 0.06612417846918106, "1015": 0.06886265426874161, "1021": 0.567397952079773, "1052": 0.42096930742263794, "1060": 0.14939609169960022, "2003": 0.16359257698059082, "2005": 0.08692999184131622, "2024": 0.3601844012737274, "2026": 0.2034190446138382, "2029": 0.12814582884311676, "2044... | 16660256 | Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogenous muscle fiber repair has been unclear. The transcription factor Pax7 marks satellite cells and is critical for establishing the adult satellite cell pool. By using a... | Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration |
{"1011": 0.2026219218969345, "1041": 0.25845035910606384, "1055": 0.5461324453353882, "1968": 0.14602625370025635, "1996": 0.35060185194015503, "2004": 0.17922431230545044, "2011": 0.14602625370025635, "2015": 0.9052929878234863, "2029": 0.07884006202220917, "2031": 0.129004567861557, "2033": 0.861702561378479, "2035":... | 16669757 | The enteric nervous system (ENS) autonomously controls gut muscle activity. Mechanosensitive enteric neurons (MEN) initiate reflex activity by responding to mechanical deformation of the gastrointestinal wall. MEN throughout the gut primarily respond to compression or stretch rather than to shear force. Some MEN are mu... | Mechanosensitivity in the enteric nervous system |
{"1011": 0.07068414986133575, "1016": 0.0058422754518687725, "1017": 0.2637155055999756, "1018": 0.43875885009765625, "1038": 0.16359257698059082, "1039": 0.31845372915267944, "1044": 0.841701865196228, "1050": 0.6260011196136475, "2002": 0.12038381397724152, "2004": 0.08603433519601822, "2005": 0.3134697377681732, "20... | 16686383 | The centromeric histone H3 variant (CenH3) is essential for chromosome segregation in eukaryotes. We identify posttranslational modifications of Saccharomyces cerevisiae CenH3, Cse4. Functional characterization of cse4 phosphorylation mutants shows growth and chromosome segregation defects when combined with kinetochor... | Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae |
{"1016": 0.25239890813827515, "1039": 0.03266380727291107, "1996": 0.25845035910606384, "2003": 0.38441169261932373, "2024": 0.09672962874174118, "2029": 0.18329764902591705, "2054": 0.151916041970253, "2057": 0.037378571927547455, "2073": 0.06337817758321762, "2079": 0.09938567131757736, "2099": 0.4450363218784332, "2... | 16691520 | The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. ... | Genome-wide analysis of estrogen receptor binding sites |
{"1037": 0.03925827145576477, "1998": 0.009718249551951885, "1999": 0.04394211992621422, "2004": 0.1212492436170578, "2028": 0.12642613053321838, "2029": 0.1229778528213501, "2038": 0.16276304423809052, "2042": 0.00875066313892603, "2045": 0.06337817758321762, "2057": 0.02316705882549286, "2071": 0.053244512528181076, ... | 16693950 | Progress in aging research is now rapid, and surprisingly, studies in a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved bet... | Replicative aging in yeast: the means to the end. |
{"1011": 0.38374659419059753, "1013": 0.07341018319129944, "1014": 0.0797421783208847, "1038": 0.6011518239974976, "1039": 0.8941729068756104, "1044": 0.3923587501049042, "1048": 0.436867892742157, "1052": 0.1994270235300064, "2004": 0.0058422754518687725, "2007": 0.37102460861206055, "2015": 0.07884006202220917, "2044... | 16701509 | BACKGROUND The prevalence of metabolic syndrome (obesity, glucose intolerance, low serum high-density lipoprotein cholesterol [HDL-C], high serum triglycerides, hypertension) is high and increasing in parallel with an increasing breast cancer incidence worldwide. HDL-C represents an important aspect of the syndrome, ye... | Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk. |
{"1011": 0.32129061222076416, "1014": 0.06337817758321762, "1019": 0.0797421783208847, "1050": 0.8608771562576294, "1052": 0.16607704758644104, "1998": 0.2719337046146393, "2003": 0.05417001247406006, "2005": 0.07793712615966797, "2007": 0.1751343309879303, "2029": 0.11081436276435852, "2048": 0.07250232994556427, "205... | 16705338 | Chemical-protein interaction (CPI) is the central topic of target identification and drug discovery. However, large scale determination of CPI is a big challenge for in vitro or in vivo experiments, while in silico prediction shows great advantages due to low cost and high accuracy. On the basis of our previous drug-ta... | Prediction of Chemical-Protein Interactions Network with Weighted Network-Based Inference Method |
{"1998": 0.2607102394104004, "2013": 0.2516399025917053, "2037": 0.02792670577764511, "2064": 0.11604541540145874, "2079": 0.304147332906723, "2084": 0.05786345899105072, "2090": 0.4487839937210083, "2114": 0.2501201331615448, "2119": 0.18411032855510712, "2129": 0.31204116344451904, "2227": 0.9209672808647156, "2275":... | 16712164 | Healthy cells utilize intricate systems to monitor their environment and mount robust responses in the event of cellular stress. Whether stress arises from external insults or defects due to mutation and disease, cells must be able to respond precisely to mount the appropriate defenses. Multi-faceted stress responses a... | Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling |
{"1011": 0.21530038118362427, "1042": 0.2763880789279938, "1051": 0.8500841856002808, "1996": 0.007782140281051397, "2003": 0.04767346754670143, "2005": 0.19541899859905243, "2008": 0.06246116757392883, "2029": 0.19862671196460724, "2079": 0.2478361576795578, "2080": 1.417065978050232, "2109": 0.14095009863376617, "213... | 16728949 | The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-dependent signaling is required for long-term regenerative potential of ... | Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System |
{"1011": 0.43875885009765625, "1015": 0.2447827309370041, "1018": 0.045809537172317505, "1023": 0.2800849378108978, "1043": 0.6441128253936768, "1044": 0.5278670787811279, "1055": 0.17922431230545044, "1060": 0.23247487843036652, "2001": 0.04113444685935974, "2002": 1.20182204246521, "2006": 0.4914994537830353, "2008":... | 16732790 | The first Swiss human embryonic stem cell (hESC) line, CH-ES1, has shown features of a malignant cell line. It originated from the only single blastomere that survived cryopreservation of an embryo, and it more closely resembles teratocarcinoma lines than other hESC lines with respect to its abnormal karyotype and its ... | A Teratocarcinoma-Like Human Embryonic Stem Cell (hESC) Line and Four hESC Lines Reveal Potentially Oncogenic Genomic Changes |
{"1011": 0.2034190446138382, "1015": 0.23864774405956268, "1048": 0.44566190242767334, "1051": 0.2969166338443756, "1055": 0.45870962738990784, "1177": 0.4151833653450012, "2007": 0.1751343309879303, "2013": 0.09406650811433792, "2015": 0.13670019805431366, "2028": 0.08064348995685577, "2029": 0.2659635543823242, "2030... | 16734530 | BACKGROUND Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. METHODS A total of 384 female patients with breast cancer were included in this study. We se... | The Association between Single-Nucleotide Polymorphisms of ORAI1 Gene and Breast Cancer in a Taiwanese Population |
{"1017": 0.6487176418304443, "1039": 0.15610189735889435, "1040": 0.15943801403045654, "1047": 0.022212404757738113, "1997": 0.05786345899105072, "2007": 0.11691460013389587, "2011": 0.009718249551951885, "2012": 0.0752234235405922, "2022": 0.8349450826644897, "2029": 0.04860413447022438, "2051": 0.12728634476661682, "... | 16736872 | Optical imaging of the dynamics of living specimens involves tradeoffs between spatial resolution, temporal resolution, and phototoxicity, made more difficult in three dimensions. Here, however, we report that rapid three-dimensional (3D) dynamics can be studied beyond the diffraction limit in thick or densely fluoresc... | Noninvasive Imaging beyond the Diffraction Limit of 3D Dynamics in Thickly Fluorescent Specimens |
{"1011": 0.2711893916130066, "1050": 0.8933739066123962, "1996": 0.27786844968795776, "1997": 0.08603433519601822, "1998": 0.012615402229130268, "2007": 0.1602703034877777, "2008": 0.03925827145576477, "2015": 0.07159364968538284, "2029": 0.23710809648036957, "2035": 0.09406650811433792, "2048": 0.012615402229130268, "... | 16736883 | Kinetochores couple chromosomes to the assembling and disassembling tips of microtubules, a dynamic behavior that is fundamental to mitosis in all eukaryotes but poorly understood. Genetic, biochemical, and structural studies implicate the Ndc80 complex as a direct point of contact between kinetochores and microtubules... | The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion |
{"1011": 0.46363574266433716, "1014": 0.23479416966438293, "1040": 0.026025565341114998, "1043": 0.5914691090583801, "1049": 0.1011524572968483, "1052": 0.19782574474811554, "2007": 0.030771657824516296, "2012": 0.1332872211933136, "2020": 0.0019512200960889459, "2025": 0.012615402229130268, "2026": 1.0485517978668213,... | 16737163 | OBJECTIVE To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). METHOD Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 t... | Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children |
{"1011": 0.13499516248703003, "1013": 0.007782140281051397, "1014": 0.32058215141296387, "1019": 0.0354953333735466, "1041": 0.01934296265244484, "1044": 0.4190443754196167, "1047": 1.2471669912338257, "1052": 0.3177432417869568, "1053": 0.004870930220931768, "1998": 0.1064341589808464, "2004": 0.47584590315818787, "20... | 16737210 | CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant. Kidney paired donation (KPD) offers incompatible donor/recipient pairs the opportunity to match for compatible transplants. Despite its increasing popularity, very few tra... | Kidney paired donation and optimizing the use of live donor organs. |
{"1011": 0.12642613053321838, "1017": 0.10731173306703568, "1038": 0.4450363218784332, "1039": 0.7115318179130554, "1044": 0.00875066313892603, "1052": 0.6218147873878479, "1056": 0.5057345628738403, "1998": 0.009718249551951885, "2002": 0.14686977863311768, "2005": 0.17840765416622162, "2007": 0.2741633653640747, "200... | 16745747 | Adult blood cell production or definitive hematopoiesis requires the transcription factor c-Myb. The closely related KAT3 histone acetyltransferases CBP (CREBBP) and p300 (EP300) bind c-Myb through their KIX domains and mice homozygous for a p300 KIX domain mutation exhibit multiple blood defects. Perplexingly, mice ho... | Genetic Interaction between Mutations in c-Myb and the KIX Domains of CBP and p300 Affects Multiple Blood Cell Lineages and Influences Both Gene Activation and Repression |
{"1003": 0.018384648486971855, "1018": 0.058784693479537964, "1050": 0.1946154683828354, "1052": 0.3824150264263153, "1997": 0.06429435312747955, "1999": 0.3743882179260254, "2001": 0.055094651877880096, "2003": 0.16524957120418549, "2004": 0.040196798741817474, "2007": 0.21293537318706512, "2012": 0.6107416749000549, ... | 16760369 | CONTEXT Clinicians and trialists have difficulty with identifying which patients are highest risk for cardiovascular events. Prior ischemic events, polyvascular disease, and diabetes mellitus have all been identified as predictors of ischemic events, but their comparative contributions to future risk remain unclear. OB... | Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. |
{"1052": 0.5472630262374878, "2000": 0.10993985831737518, "2003": 0.00875066313892603, "2005": 0.2659635543823242, "2026": 0.6813592314720154, "2047": 0.66441810131073, "2064": 0.1619328260421753, "2077": 0.08782484382390976, "2078": 0.37102460861206055, "2079": 0.151916041970253, "2089": 0.06429435312747955, "2092": 0... | 16787954 | Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming emergence of drug resistance is the major objective of tuberculosis (TB) drug development. Using a matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging suite in a biosafety containment facility, we show tha... | The association between sterilizing activity and drug distribution into tuberculosis lesions |
{"1996": 0.28597161173820496, "2003": 0.25995752215385437, "2054": 0.06977381557226181, "2075": 0.21135559678077698, "2076": 0.07884006202220917, "2079": 0.34300774335861206, "2083": 0.3723714053630829, "2090": 0.5805994272232056, "2109": 0.16359257698059082, "2129": 0.10993985831737518, "2236": 0.015504186972975731, "... | 16790253 | Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control... | Notch signaling: cell fate control and signal integration in development. |
{"1011": 0.26446542143821716, "1014": 0.07793712615966797, "1020": 0.5551415085792542, "1038": 0.1693800985813141, "1040": 0.4425300657749176, "1048": 0.9170717000961304, "1050": 0.20421554148197174, "1052": 0.25239890813827515, "2005": 0.055094651877880096, "2007": 0.2852376699447632, "2008": 0.0019512200960889459, "2... | 16806763 | Increasing evidence suggests long non-coding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, however, few related lncRNA signatures have been established for prediction of cancer prognosis. We aimed to develop a lncRNA signature to improve prognosis prediction of colorectal cancer (CRC). Using a lncRNA-m... | A long non-coding RNA signature to improve prognosis prediction of colorectal cancer |
{"1038": 0.9546096324920654, "1051": 0.4311734735965729, "1057": 0.14518201351165771, "1997": 0.07068414986133575, "2003": 0.1401015669107437, "2005": 0.03266380727291107, "2007": 0.0019512200960889459, "2011": 0.06429435312747955, "2015": 0.05046287178993225, "2046": 0.08064348995685577, "2062": 0.09672962874174118, "... | 16812091 | CONTEXT Osteoporosis causes substantial morbidity and costs $13.8 billion annually in the United States. Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a preventive treatment course. Bone mineral densitometry has become more widely available and commonly used in pract... | Clinical use of bone densitometry: scientific review. |
{"1009": 0.6128603219985962, "1011": 0.34370049834251404, "1015": 0.3191637098789215, "1038": 0.48430517315864563, "1040": 0.010684899985790253, "1052": 0.053244512528181076, "1058": 0.18411032855510712, "1157": 0.4113073945045471, "1999": 0.20421554148197174, "2003": 0.39696553349494934, "2005": 0.10555581003427505, "... | 16826810 | Vascular calcification is an advanced feature of atherosclerosis for which no effective therapy is available. To investigate the modulation or reversal of calcification, we identified calcifying progenitor cells and investigated their calcifying/decalcifying potentials. Cells from the aortas of mice were sorted into fo... | Vascular Calcifying Progenitor Cells Possess Bidirectional Differentiation Potentials |
{"1039": 0.004870930220931768, "1047": 0.6086184978485107, "1999": 0.0606246218085289, "2004": 0.2607102394104004, "2005": 0.02316705882549286, "2008": 0.056018441915512085, "2011": 0.39696553349494934, "2015": 0.43875885009765625, "2024": 0.12986256182193756, "2029": 0.2516399025917053, "2049": 0.2576959431171417, "20... | 16839245 | The basic biology of the cell division cycle and its control by protein kinases was originally studied through genetic and biochemical studies in yeast and other model organisms. The major regulatory mechanisms identified in this pioneer work are conserved in mammals. However, recent studies in different cell types or ... | Physiological relevance of cell cycle kinases. |
{"1011": 0.13499516248703003, "1015": 0.1905880719423294, "1043": 0.5590575933456421, "2004": 0.06337817758321762, "2005": 0.11517547070980072, "2007": 0.12728634476661682, "2008": 0.034552380442619324, "2011": 0.3269403576850891, "2015": 0.8281423449516296, "2020": 0.016465263441205025, "2029": 0.1212492436170578, "20... | 16853734 | Human mesenchymal stem cells (MSCs) have increasingly been used as cellular vectors for the delivery of therapeutic genes to tumors. However, the precise mechanism of mobilization remains poorly defined. In this study, MSCs that expressed similar cell surface markers and exhibited multilineage differentiation potential... | Matrix Metalloproteinase 1 Is Necessary for the Migration of Human Bone Marrow-Derived Mesenchymal Stem Cells Toward Human Glioma |
{"1014": 0.11430477350950241, "1019": 0.07068414986133575, "2009": 0.11256109178066254, "2022": 0.17267228662967682, "2042": 0.07884006202220917, "2052": 0.3656192123889923, "2061": 0.06703783571720123, "2062": 0.43244171142578125, "2064": 0.11430477350950241, "2071": 0.014542185701429844, "2075": 0.13499516248703003, ... | 16855829 | Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adulthood. Victims are generally reported to be weaker than the bullies. 2 3 This would suggest that very short pupils are more likely to be v... | Bullying in school: are short pupils at risk? Questionnaire study in a cohort. |
{"1011": 0.1677299439907074, "1015": 0.5045560002326965, "1018": 0.03831886500120163, "1019": 0.10467668622732162, "1054": 0.4574742913246155, "1996": 0.026025565341114998, "1999": 0.9232974052429199, "2003": 0.11951763927936554, "2004": 0.5016035437583923, "2008": 0.09584271162748337, "2011": 0.3547199070453644, "2013... | 16863359 | Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whereas inflammasome-mediated activation is heavily studied in hematopoietic macrophages and dendritic cells, much less is known about microglia, resident... | Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases. |
{"1011": 0.44753631949424744, "1017": 0.05970508232712746, "1049": 0.6086184978485107, "1053": 0.7408206462860107, "1999": 0.0174254160374403, "2002": 0.7934166193008423, "2004": 0.06246116757392883, "2007": 0.2184450328350067, "2011": 0.32341301441192627, "2029": 0.32058215141296387, "2039": 0.2223619967699051, "2048"... | 16882895 | In the present study, we constructed a lentivirus vector encoding the miR-29a precursor and established two stably infected cell lines, PLC-29a and 97L-29a. The overexpression of miR-29a was confirmed by TaqMan RT-PCR and significantly suppressed the growth of the hepatocellular carcinoma cell l... | microRNA-29a suppresses cell proliferation by targeting SPARC in hepatocellular carcinoma. |
{"1009": 0.41840189695358276, "1011": 0.11778303235769272, "1015": 0.08603433519601822, "1040": 0.5540198087692261, "1043": 0.40806588530540466, "1999": 0.1808556467294693, "2007": 0.18654440343379974, "2011": 0.22782009840011597, "2020": 0.06154331564903259, "2029": 0.2160874605178833, "2034": 0.21372433006763458, "20... | 16905344 | Injured axons of the adult CNS undergo lengthy retraction from the initial site of axotomy after spinal cord injury. Macrophage infiltration correlates spatiotemporally with this deleterious phenomenon, but the direct involvement of these inflammatory cells has not been demonstrated. In the present study, we examined t... | Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions |
{"1011": 0.1994270235300064, "1015": 0.5209306478500366, "1017": 0.6522845029830933, "1052": 0.5773153901100159, "1996": 0.2231435477733612, "1997": 0.06429435312747955, "1998": 0.025073638185858727, "1999": 0.5427330136299133, "2000": 0.0038986403960734606, "2005": 0.07884006202220917, "2006": 0.18329764902591705, "20... | 16927286 | In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit. Here, we report 11 single-particle cryo-electron microscopy (cryoEM) reconstructions of the complex of bacterial 30S subunit with initiator tRN... | Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation |
{"1011": 0.2231435477733612, "1055": 0.5651806592941284, "1057": 0.6553317308425903, "1996": 0.27044451236724854, "1997": 0.129004567861557, "1999": 0.27934664487838745, "2001": 0.05786345899105072, "2007": 0.05970508232712746, "2011": 0.29981520771980286, "2013": 0.3325583338737488, "2015": 0.3464667797088623, "2024":... | 16929739 | In higher eukaryotes, introns are spliced out of protein-coding mRNAs by the spliceosome, a massive complex comprising five non-coding RNAs (ncRNAs) and about 200 proteins. By comparing the differences between spliceosomal proteins from many basal eukaryotic lineages, it is possible to infer properties of the splicing ... | Corresponding Author: |
{"1017": 0.12814582884311676, "1039": 0.004870930220931768, "1052": 0.07341018319129944, "2011": 0.037378571927547455, "2029": 0.14518201351165771, "2037": 0.014542185701429844, "2048": 0.12814582884311676, "2051": 0.02412080205976963, "2060": 0.043007105588912964, "2076": 0.2918238639831543, "2090": 0.1384023278951645... | 16939583 | Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals. Here we compare cortical progenitor cell output in humans and three nonhuman primates using directed differentiation of pluripotent stem cells (PSCs) in adherent two-dimensiona... | 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. |
{"1043": 0.5968599319458008, "2000": 0.11168810725212097, "2003": 0.2719337046146393, "2005": 0.18492233753204346, "2006": 0.007782140281051397, "2011": 0.03925827145576477, "2015": 0.030771657824516296, "2054": 0.06795065850019455, "2064": 0.4374985992908478, "2066": 0.10906458646059036, "2075": 0.3269403576850891, "2... | 16962732 | We describe a technique for rapid labeling of a large number of cells in the nervous system with many different colors. By delivering lipophilic dye-coated particles to neuronal preparations with a "gene gun," individual neurons and glia whose membranes are contacted by the particles are quickly labeled. Using particle... | Multicolor “DiOlistic” Labeling of the Nervous System Using Lipophilic Dye Combinations |
{"1011": 0.3588210940361023, "1039": 0.23479416966438293, "1059": 0.8885661959648132, "1060": 0.016465263441205025, "1062": 1.1262223720550537, "2002": 0.3560888469219208, "2006": 0.32553088665008545, "2008": 0.03266380727291107, "2028": 0.01934296265244484, "2029": 0.06337817758321762, "2031": 0.09317722171545029, "20... | 16963081 | Birds are difficult to sex. Nestlings rarely show sex-linked morphology and we estimate that adult females appear identical to males in over 50% of the world's bird species. This problem can hinder both evolutionary studies and human-assisted breeding of birds. DNA-based sex identification provides a solution. We descr... | A DNA test to sex most birds. |
{"1011": 0.34508460760116577, "1015": 0.5238267183303833, "1043": 0.846739649772644, "1996": 0.1994270235300064, "2000": 0.13071982562541962, "2008": 0.0317181795835495, "2015": 0.2637155055999756, "2025": 0.06520967930555344, "2028": 0.09584271162748337, "2029": 0.23710809648036957, "2034": 0.03360854089260101, "2043"... | 16964262 | Precursor cells of the embryonic cortex sequentially generate neurons and then glial cells, but the mechanisms regulating this neurogenic-to-gliogenic transition are unclear. Using cortical precursor cultures, which temporally mimic this in vivo differentiation pattern, we demonstrate that cortical neurons synthesize a... | Evidence that Embryonic Neurons Regulate the Onset of Cortical Gliogenesis via Cardiotrophin-1 |
{"1011": 0.42225050926208496, "1017": 0.14433705806732178, "1040": 0.04953393340110779, "1045": 0.2822965085506439, "1050": 0.32129061222076416, "1056": 0.4400174915790558, "1059": 0.39367714524269104, "2010": 0.5618454217910767, "2011": 0.16276304423809052, "2021": 0.176772341132164, "2029": 0.14433705806732178, "2036... | 16966326 | Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological feature of degenerating neurons in various neurodegenerative diseases. However, the mo... | The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity |
{"1014": 0.42735910415649414, "1015": 0.1384023278951645, "1016": 0.04674193635582924, "1017": 0.20580662786960602, "1018": 0.4437839686870575, "1019": 0.3177432417869568, "1021": 0.11168810725212097, "1022": 0.18492233753204346, "1023": 0.004870930220931768, "1053": 0.49686139822006226, "1997": 0.15023678541183472, "1... | 16979690 | CONTEXT Anxiety about bias, lack of accountability, and poor quality of peer review has led to questions about the imbalance in anonymity between reviewers and authors. OBJECTIVE To evaluate the effect on the quality of peer review of blinding reviewers to the authors' identities and requiring reviewers to sign their r... | Effect on the quality of peer review of blinding reviewers and asking them to sign their reports: a randomized controlled trial. |
{"1003": 0.32199856638908386, "1017": 0.12384103983640671, "1020": 0.3547199070453644, "1022": 0.35334911942481995, "1023": 0.30989447236061096, "1039": 0.14264501631259918, "1041": 0.2689530849456787, "1048": 0.5607312321662903, "1056": 0.5668440461158752, "1057": 0.12470348179340363, "1058": 0.02412080205976963, "200... | 16980892 | BACKGROUND More than 2 million U.S. women receive an equivocal cervical cytologic diagnosis (atypical squamous cells of undetermined significance [ASCUS]) each year. Effective colposcopy triage strategies are needed to identify the minority of women who have clinically significant disease while avoiding excessive follo... | 2001. Comparison of three management strategies for patients with atypical squamous cells of undetermined significance. Baseline results from a randomized trial |
{"1009": 0.6043586730957031, "1011": 0.3519764244556427, "1016": 0.4770587682723999, "1043": 0.8957691192626953, "1996": 0.09406650811433792, "1999": 0.06977381557226181, "2004": 0.37707099318504333, "2007": 0.25845035910606384, "2008": 0.02412080205976963, "2011": 0.03360854089260101, "2015": 0.016465263441205025, "20... | 16999023 | To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgenic mice. Sox2-GFP cells in the subgranular zone (SGZ) express markers specific for progenitors, but they represent two morphologically distinct populations that differ in proliferation levels. Lentivirus- and re... | Cell Stem Cell Article In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2 + Neural Stem Cells in the Adult Hippocampus |
{"1014": 0.2034190446138382, "1020": 0.5707147121429443, "1048": 0.12038381397724152, "1049": 0.48610860109329224, "1055": 0.08871890604496002, "2004": 0.022212404757738113, "2015": 0.0842406153678894, "2039": 0.03831886500120163, "2043": 0.2881702482700348, "2051": 0.19862671196460724, "2058": 0.11604541540145874, "20... | 17000834 | OBJECTIVE To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis. DESIGN Population based case-control study. SETTING Tasmania, latitudes 41-3 degrees S. PARTICIPANTS 136 cases with multiple sclerosis and 272 controls randomly drawn from the community and matched on sex and ... | Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. |
{"1011": 0.05694137513637543, "1019": 0.39893341064453125, "1054": 0.5370414853096008, "1996": 0.0913962796330452, "2005": 0.4041621685028076, "2008": 0.04767346754670143, "2011": 0.18573370575904846, "2029": 0.38905516266822815, "2075": 0.08871890604496002, "2076": 0.5301685929298401, "2079": 0.1358480453491211, "2109... | 17017465 | The small GTPases, Rab5 and Rac, are essential for endocytosis and actin remodeling, respectively. Coordination of these processes is critical to achieve spatial restriction of intracellular signaling, which is essential for a variety of polarized functions. Here, we show that clathrin- and Rab5-mediated endocytosis ar... | Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration |
{"1009": 0.24859806895256042, "1011": 0.33605360984802246, "1014": 0.5427330136299133, "1017": 0.012615402229130268, "1026": 0.30989447236061096, "1037": 0.13499516248703003, "1038": 0.49030399322509766, "1043": 0.32905077934265137, "1048": 0.2493593990802765, "1050": 0.14602625370025635, "1052": 0.6446255445480347, "2... | 17021845 | The aim of the present study was to analyze the stem cell marker, Nanog gene, for the diagnosis and prognosis of lung cancer cases, and to study its application in the diagnosis of lung cancer. In total, 100 patients diagnosed with lung cancer between April, 2013 and May, 2015 were included in the present study. The pa... | Significance of stem cell marker Nanog gene in the diagnosis and prognosis of lung cancer |
{"1011": 0.04487626627087593, "1056": 1.0973093509674072, "1996": 0.010684899985790253, "2013": 0.3850763738155365, "2034": 0.08154398202896118, "2058": 0.27934664487838745, "2066": 0.6317287683486938, "2079": 0.18816383183002472, "2099": 0.24018502235412598, "2109": 0.007782140281051397, "2119": 0.10555581003427505, "... | 17023584 | The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is understood to be a complex process, driven by a lack of normal immune homeostatic functions and excessive production of proinflammator... | Current knowledge and future directions of TLR and NOD signaling in sepsis |
{"1011": 0.16359257698059082, "1996": 0.22937409579753876, "1999": 0.07884006202220917, "2012": 0.09584271162748337, "2029": 0.06977381557226181, "2043": 0.10467668622732162, "2051": 0.4891071021556854, "2064": 0.25995752215385437, "2067": 0.3750596046447754, "2073": 0.07341018319129944, "2076": 0.5887627601623535, "20... | 17049436 | During development of the vertebrate neuroepithelium, the nucleus in neural progenitor cells (NPCs) moves from the apex toward the base and returns to the apex (called interkinetic nuclear migration) at which point the cell divides. The fate of the resulting daughter cells is thought to depend on the sampling by the mo... | Concentration Sensing by the Moving Nucleus in Cell Fate Determination: A Computational Analysis |
{"1011": 0.14433705806732178, "1015": 0.3353555500507355, "1023": 0.12384103983640671, "1039": 0.5914691090583801, "1041": 0.0752234235405922, "1051": 0.1619328260421753, "1996": 0.11604541540145874, "2011": 0.3241194784641266, "2015": 0.05046287178993225, "2028": 0.2711893916130066, "2029": 0.06154331564903259, "2037"... | 17050065 | Following prolonged exposure to an odorant, C. elegans exhibits a diminished response to the odorant for several hours. This olfactory adaptation is odorant selective; animals can adapt independently to different odorants sensed by a single pair of olfactory neurons, the AWC neurons. The mechanism of olfactory adaptati... | Odorant-specific adaptation pathways generate olfactory plasticity in C. elegans |
{"1011": 0.11343330889940262, "1016": 0.08513788133859634, "1040": 0.8143964409828186, "1042": 0.6950984001159668, "1060": 0.3381449282169342, "1999": 0.025073638185858727, "2005": 0.2954642176628113, "2008": 0.11691460013389587, "2011": 0.3656192123889923, "2015": 0.6960725784301758, "2029": 0.2493593990802765, "2043"... | 17055665 | FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcription of several IIS com... | Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling |
{"1014": 0.04674193635582924, "1019": 0.1685553640127182, "1039": 0.1734936386346817, "1044": 0.12728634476661682, "2000": 0.05139094591140747, "2001": 0.016465263441205025, "2002": 0.2749055027961731, "2007": 0.12556517124176025, "2039": 0.28082266449928284, "2041": 0.09406650811433792, "2043": 0.1602703034877777, "20... | 17077004 | OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). DESIGN Prospective cohort study of adults with HIV (Swiss HIV cohort study). SETTING Seven outpatient clinics throughout Switzerland. PARTICIPANTS The ... | Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study. |
{"1020": 0.8298473954200745, "1043": 0.5162794589996338, "1054": 0.04953393340110779, "2005": 0.03831886500120163, "2006": 0.6286086440086365, "2008": 0.14433705806732178, "2025": 0.1510767638683319, "2029": 0.2837681770324707, "2079": 0.04207121208310127, "2099": 0.7295845746994019, "2106": 0.04113444685935974, "2109"... | 17081238 | Taking advantage of the restricted expression of metabotropic glutamate receptor subtype 6 (mGluR6) in retinal ON bipolar cells, we generated knockout mice lacking mGluR6 expression. The homozygous mutant mice showed a loss of ON responses but unchanged OFF responses to light. The mutant mice displayed no obvious chang... | Specific deficit of the ON response in visual transmission by targeted disruption of the mGIuR6 gene |
{"1014": 0.5478278398513794, "1015": 0.13755162060260773, "1018": 0.016465263441205025, "1043": 0.5057345628738403, "1051": 0.4914994537830353, "1052": 0.045809537172317505, "2013": 0.1485546976327896, "2015": 0.05786345899105072, "2029": 0.09317722171545029, "2035": 0.4734157919883728, "2087": 0.37035053968429565, "20... | 17088791 | Most multiple case families of young onset breast cancer and ovarian cancer are thought to be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2. However, these mutations are uncommon in the population and they probably account for only a few percent of all breast cancer incidence. A much large... | Common BRCA1 variants and susceptibility to breast and ovarian cancer in the general population. |
{"1006": 0.040196798741817474, "1038": 0.28450319170951843, "1044": 0.00875066313892603, "1050": 0.46363574266433716, "1998": 0.07793712615966797, "1999": 0.6446255445480347, "2003": 0.16359257698059082, "2006": 0.10731173306703568, "2011": 0.3012613356113434, "2012": 0.15442965924739838, "2015": 0.0842406153678894, "2... | 17097974 | Nitric oxide (NO) is produced in the vascular endothelium and is a potent vasodilator substance that participates in the regulation of local vascular tone. Exercise causes peculiar changes in systemic and regional blood flow, i.e., an increase of systemic blood flow and a redistribution of local tissue blood flow, by w... | Exercise causes a tissue-specific change of NO production in the kidney and lung. |
{"1011": 0.1734936386346817, "1041": 0.7701805830001831, "1042": 0.11517547070980072, "1043": 0.7995813488960266, "1999": 0.058784693479537964, "2011": 0.2447827309370041, "2029": 0.18329764902591705, "2031": 0.13414156436920166, "2038": 0.030771657824516296, "2051": 0.1685553640127182, "2064": 0.04674193635582924, "20... | 17101262 | Protoplasmic astrocytes in mammalian CNS tissues in vivo have a highly complex 3D morphology, but in dissociated cell cultures they often assume a flattened, fibroblast-like morphology bearing only a few, simple processes. By fluorescent labeling and confocal reconstruction we show that many astrocytes in organotypic h... | Ballistic labeling and dynamic imaging of astrocytes in organotypic hippocampal slice cultures |
{"1042": 0.8925741910934448, "1996": 0.3519764244556427, "1998": 0.4462870955467224, "2000": 0.00875066313892603, "2005": 0.04674193635582924, "2007": 0.052318159490823746, "2008": 0.0317181795835495, "2011": 0.2637155055999756, "2013": 0.43812891840934753, "2025": 0.04394211992621422, "2029": 0.2749055027961731, "2033... | 17119869 | The pancreas emerges independently from dorsal and ventral domains of embryonic gut endoderm. Gene inactivation experiments in mice have identified factors required for dorsal pancreas development, but factors that initiate the ventral pancreas have remained elusive. In this study, we investigated the hypothesis that t... | A bipotential precursor population for pancreas and liver within the embryonic endoderm. |
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