spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.03360854089260101, "1015": 0.5381823778152466, "1017": 0.26296505331993103, "1018": 0.28082266449928284, "1043": 0.401551216840744, "1044": 0.013579257763922215, "1050": 0.24631060659885406, "1054": 0.0770333781838417, "2028": 0.14602625370025635, "2029": 0.3757305145263672, "2048": 0.12556517124176025, "205... | 17123316 | Perturbations in neuregulin-1 (NRG1)/ErbB4 function have been associated with schizophrenia. Affected patients exhibit altered levels of these proteins and display hypofunction of glutamatergic synapses as well as altered neuronal circuitry. However, the role of NRG1/ErbB4 in regulating synapse maturation and neuronal ... | ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. |
{"1996": 0.00875066313892603, "2029": 0.013579257763922215, "2058": 0.07341018319129944, "2064": 0.272677481174469, "2070": 0.016465263441205025, "2071": 0.0317181795835495, "2079": 0.25694093108177185, "2083": 0.18329764902591705, "2087": 0.10731173306703568, "2090": 0.06977381557226181, "2109": 0.20102575421333313, "... | 17123657 | Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these examples. Such efforts suggest that some of the most interesting properties of transmembrane helix inter... | Dynamic Helix Interactions in Transmembrane Signaling |
{"1003": 0.1930064558982849, "1014": 0.2969166338443756, "1023": 0.0009760859538801014, "1050": 0.42990362644195557, "1057": 0.15693697333335876, "1997": 0.013579257763922215, "2012": 0.3870677351951599, "2025": 0.19541899859905243, "2039": 0.0797421783208847, "2042": 0.02792670577764511, "2053": 0.2881702482700348, "2... | 17124832 | CONTEXT Previous studies indicate that the population attributable risk (PAR) of bladder cancer for tobacco smoking is 50% to 65% in men and 20% to 30% in women and that current cigarette smoking triples bladder cancer risk relative to never smoking. During the last 30 years, incidence rates have remained stable in the... | Association between smoking and risk of bladder cancer among men and women. |
{"1043": 1.0841858386993408, "1044": 0.2918238639831543, "1048": 0.1808556467294693, "1996": 0.10467668622732162, "2029": 0.1212492436170578, "2037": 0.07159364968538284, "2039": 0.13925230503082275, "2058": 0.007782140281051397, "2076": 0.10818854719400406, "2079": 0.49864232540130615, "2121": 0.24401791393756866, "21... | 17150648 | Glial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphology. Here, we demons... | Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. |
{"1003": 0.013579257763922215, "1014": 0.6684301495552063, "2062": 0.13071982562541962, "2063": 0.02887592278420925, "2064": 0.28963330388069153, "2084": 0.29619070887565613, "2085": 0.10906458646059036, "2090": 0.7370892763137817, "2102": 0.4855078160762787, "2104": 0.24325250089168549, "2109": 0.2018241584300995, "21... | 17163294 | BACKGROUND Accumulating evidence has shown that cancer cell metabolism differs from that of normal cells. However, up to now it is not clear whether different cancer types are characterized by a specific metabolite profile. Therefore, this study aims to evaluate whether the plasma metabolic phenotype allows to discrimi... | Metabolic phenotyping of human blood plasma: a powerful tool to discriminate between cancer types? |
{"1044": 0.056018441915512085, "2007": 0.3850763738155365, "2050": 0.151916041970253, "2053": 0.3409265875816345, "2090": 0.259204238653183, "2100": 0.2247048318386078, "2104": 0.6160298585891724, "2109": 0.15526613593101501, "2152": 0.0038986403960734606, "2177": 0.3141832649707794, "2179": 0.34577593207359314, "2265"... | 17168045 | BACKGROUND This study sought to describe and quantify microcirculatory changes in the mucosal surfaces of patients with severe malaria, by direct in vivo observation using orthogonal polarization spectral (OPS) imaging. METHODS The microcirculation in the rectal mucosa of adult patients with severe malaria was assessed... | Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria. |
{"1015": 0.27786844968795776, "1051": 0.31132611632347107, "1997": 0.07159364968538284, "1999": 0.27044451236724854, "2004": 0.3191637098789215, "2006": 0.26446542143821716, "2007": 0.15610189735889435, "2011": 0.0038986403960734606, "2012": 0.2470736801624298, "2013": 0.2478361576795578, "2015": 0.1485546976327896, "2... | 17173492 | No microorganism capable of anaerobic growth on methane as the sole carbon source has yet been cultivated. Consequently, information about these microbes has been inferred from geochemical and microbiological observations of field samples. Stable isotope analysis of lipid biomarkers and rRNA gene surveys have implicate... | Multiple archaeal groups mediate methane oxidation in anoxic cold seep sediments. |
{"1011": 0.23324857652187347, "1040": 0.04113444685935974, "1050": 0.9052929878234863, "1054": 0.49923527240753174, "2003": 0.23710809648036957, "2004": 0.1485546976327896, "2011": 0.0174254160374403, "2029": 0.16690383851528168, "2039": 0.4337083101272583, "2043": 0.10731173306703568, "2054": 0.23092569410800934, "207... | 17188921 | Cell migration is a process which is essential during embryonic development, throughout adult life and in some pathological conditions. Cadherins, and more specifically the neural cell adhesion molecule N-cadherin, play an important role in migration. In embryogenesis, N-cadherin is the key molecule during gastrulation... | N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. |
{"1011": 0.21214580535888672, "1038": 0.22782009840011597, "1042": 0.3177432417869568, "1043": 0.40741631388664246, "1055": 0.6553317308425903, "1056": 0.41840189695358276, "1997": 0.004870930220931768, "1999": 0.15359249711036682, "2007": 0.17020416259765625, "2011": 0.004870930220931768, "2029": 0.31132611632347107, ... | 17194716 | In this study, the mechanisms of actin-bundling in filopodia were examined. Analysis of cellular localization of known actin cross-linking proteins in mouse melanoma B16F1 cells revealed that fascin was specifically localized along the entire length of all filopodia, whereas other actin cross-linkers were not. RNA inte... | Role of fascin in filopodial protrusion |
{"1015": 0.1734936386346817, "1036": 0.4537591338157654, "1997": 0.037378571927547455, "2003": 0.19782574474811554, "2005": 0.18329764902591705, "2008": 0.1889725625514984, "2028": 0.040196798741817474, "2029": 0.319873183965683, "2048": 0.32199856638908386, "2054": 0.25088030099868774, "2076": 0.052318159490823746, "2... | 17195001 | The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and metabolism in response to environmental cues. Here, highlighting contributions from studies in model organisms, we review mammalian TOR complexes and the signaling branches they mediate. TOR is part of two distinct multiprotein c... | TOR Signaling in Growth and Metabolism |
{"1011": 0.1510767638683319, "1017": 0.053244512528181076, "1041": 1.0151457786560059, "1996": 0.19381128251552582, "2003": 0.2954642176628113, "2012": 0.13925230503082275, "2046": 0.034552380442619324, "2064": 0.11691460013389587, "2073": 0.23092569410800934, "2079": 0.24325250089168549, "2093": 0.1905880719423294, "2... | 17208742 | The Escherichia coli chemotaxis network is a model system for biological signal processing. In E. coli, transmembrane receptors responsible for signal transduction assemble into large clusters containing several thousand proteins. These sensory clusters have been observed at cell poles and future division sites. Despit... | Self-Organization of the Escherichia coli Chemotaxis Network Imaged with Super-Resolution Light Microscopy |
{"1011": 0.0058422754518687725, "1039": 0.08154398202896118, "1996": 0.2837681770324707, "1998": 0.10818854719400406, "2003": 0.22704219818115234, "2004": 0.025073638185858727, "2008": 0.10203468054533005, "2011": 0.1677299439907074, "2013": 0.13243216276168823, "2015": 0.28082266449928284, "2024": 0.4356052577495575, ... | 17209919 | Cilia are sensory organelles that protrude from cell surfaces to monitor the surrounding environment. In addition to its role as sensory receiver, the cilium also releases extracellular vesicles (EVs). The release of sub-micron sized EVs is a conserved form of intercellular communication used by all three kingdoms of l... | Ciliary Extracellular Vesicles: Txt Msg Organelles |
{"1011": 0.030771657824516296, "1048": 0.36086538434028625, "1050": 0.4093637466430664, "1054": 0.2689530849456787, "1164": 0.5903874635696411, "2003": 0.3019835948944092, "2005": 0.13499516248703003, "2008": 0.17020416259765625, "2029": 0.18978065252304077, "2066": 0.26446542143821716, "2079": 0.17267228662967682, "20... | 17223891 | NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. We analyzed mice deficient in Nlrp12 to study its role in inflammatory diseases such ... | The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. |
{"1009": 0.8400169610977173, "1011": 0.33675122261047363, "1017": 0.13071982562541962, "1039": 0.49982786178588867, "1047": 1.022197961807251, "1062": 0.7220231294631958, "2004": 0.8195732831954956, "2007": 0.09317722171545029, "2011": 0.3777405619621277, "2012": 0.2034190446138382, "2029": 0.08871890604496002, "2063":... | 17231273 | Energy deficiency and dysfunction of the Na+, K+-ATPase are common consequences of many pathological insults. The nature and mechanism of cell injury induced by impaired Na+, K+-ATPase, however, are not well defined. We used cultured cortical neurons to examine the hypothesis that blocking the Na+, K+-ATPase induces ap... | Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons |
{"1997": 0.021256839856505394, "2047": 0.040196798741817474, "2052": 0.4673144817352295, "2058": 0.2531573474407196, "2062": 0.11168810725212097, "2071": 0.2493593990802765, "2085": 0.15943801403045654, "2095": 0.4914994537830353, "2097": 0.2822965085506439, "2111": 0.12470348179340363, "2116": 0.4481603503227234, "215... | 17236106 | AIM To examine the potential effects of replacing the Swedish alcohol retail system with a private licensing system on alcohol consumption and alcohol-related harm. DESIGN Two possible scenarios were analysed: (1) replacing the current alcohol retail monopoly with private licensed stores that specialize in alcohol sale... | Potential consequences of replacing a retail alcohol monopoly with a private licence system: results from Sweden. |
{"1011": 0.17431432008743286, "1017": 0.15526613593101501, "1051": 0.14602625370025635, "1056": 0.8212929964065552, "1996": 0.06154331564903259, "1998": 0.10203468054533005, "2012": 0.045809537172317505, "2029": 0.3034266233444214, "2035": 0.2317005842924118, "2047": 0.20102575421333313, "2073": 0.22157983481884003, "2... | 17240457 | Hundreds of different proteins regulate and implement transcription in Saccharomyces. Yet their interrelationships have not been investigated on a comprehensive scale. Here we determined the genome-wide binding locations of 200 transcription-related proteins, under normal and acute heat-shock conditions. This study dis... | A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. |
{"1011": 0.2637155055999756, "1015": 0.14179791510105133, "1038": 0.6931471824645996, "1053": 0.06612417846918106, "1996": 0.18492233753204346, "1999": 0.0009760859538801014, "2003": 0.045809537172317505, "2005": 0.08064348995685577, "2007": 0.26296505331993103, "2026": 0.6970458030700684, "2029": 0.1994270235300064, "... | 17271462 | The quiescent state is thought to be an indispensable property for the maintenance of hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, known as the stem cell niches, is critical for adult hematopoiesis in the bone marrow (BM). Here, we demonstrate that HSCs expressing the re... | Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche |
{"1014": 0.4002431631088257, "1019": 0.0174254160374403, "1020": 0.016465263441205025, "1021": 0.25694093108177185, "1022": 0.10203468054533005, "1023": 0.07159364968538284, "1026": 0.05786345899105072, "1038": 0.5729197263717651, "1039": 0.6358738541603088, "1041": 0.0354953333735466, "1050": 0.25239890813827515, "105... | 17324544 | BACKGROUND The prevalence of diabetes is increasing in all industrialized countries and its prevention has become a public health priority. However, the predictors of diabetes risk are insufficiently understood. We evaluated, whether 31 novel biomarkers could help to predict the risk of incident diabetes. METHODS AND F... | Thirty-One Novel Biomarkers as Predictors for Clinically Incident Diabetes |
{"1048": 0.5450005531311035, "1999": 0.21372433006763458, "2000": 0.0606246218085289, "2004": 0.23015019297599792, "2005": 0.304147332906723, "2006": 0.013579257763922215, "2011": 0.3870677351951599, "2029": 0.08154398202896118, "2046": 0.2561853528022766, "2064": 0.4067663550376892, "2071": 0.0009760859538801014, "207... | 17327939 | Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their activation have been explored in vaccine development. Here we investigate whether nanoparticles can be used as a vaccine platform by targeting lymph node–residing dendritic cells via interstitial... | Exploiting lymphatic transport and complement activation in nanoparticle vaccines |
{"1011": 0.07250232994556427, "1039": 0.6872705817222595, "2003": 0.11517547070980072, "2011": 0.42353010177612305, "2012": 0.1808556467294693, "2029": 0.2184450328350067, "2046": 0.13157635927200317, "2179": 0.22859740257263184, "2184": 0.16690383851528168, "2239": 1.2721059322357178, "2278": 0.12642613053321838, "229... | 17333231 | The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc). Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative proteinopathies such as Alzheimer's disease. PrP(C) is shed at the p... | The sheddase ADAM10 is a potent modulator of prion disease |
{"1009": 0.7105726003646851, "1011": 0.23633737862110138, "1014": 0.037378571927547455, "1016": 0.2160874605178833, "1043": 0.46486347913742065, "1050": 0.034552380442619324, "1051": 0.1477125883102417, "1060": 0.5427330136299133, "1062": 0.9470623731613159, "1997": 0.030771657824516296, "1998": 0.03360854089260101, "2... | 17338543 | Micromolar concentrations of extracellular Zn2+ are known to antagonize native NMDA receptors via a dual mechanism involving both a voltage-independent and a voltage-dependent inhibition. We have tried to evaluate the relative importance of these two effects and their subunit specificity on recombinant NMDA receptors e... | High-affinity zinc inhibition of NMDA NR1-NR2A receptors |
{"1022": 0.0797421783208847, "1999": 0.14686977863311768, "2003": 0.2394166737794876, "2004": 0.11951763927936554, "2005": 0.10467668622732162, "2008": 0.22859740257263184, "2011": 0.24401791393756866, "2029": 0.3464667797088623, "2038": 0.14433705806732178, "2063": 0.14095009863376617, "2069": 0.08154398202896118, "20... | 17368516 | We describe a second primase in human cells, PrimPol, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotides. Moreover, PrimPol is also a DNA polymerase tailored to bypass the most common oxidative lesions in DNA, such as abasic sites and 8-oxoguan... | PrimPol, an Archaic Primase/Polymerase Operating in Human Cells |
{"1003": 0.22704219818115234, "1020": 0.4950772523880005, "1056": 0.36426326632499695, "1057": 0.40546512603759766, "1997": 0.4580921530723572, "2000": 0.11256109178066254, "2012": 0.6155022978782654, "2022": 0.0174254160374403, "2025": 0.6833335757255554, "2044": 0.1401015669107437, "2046": 0.1229778528213501, "2050":... | 17374970 | AIM To determine attrition and predictors of academic success among medical students at University of Split, Croatia. METHODS We analysed academic records of 2054 students enrolled during 1979-2008 period. RESULTS We found that 26% (533/2054) of enrolled students did not graduate. The most common reasons for attrition ... | Predictors of Attrition and Academic Success of Medical Students: A 30-Year Retrospective Study |
{"2029": 0.12038381397724152, "2064": 0.0752234235405922, "2079": 0.08782484382390976, "2094": 0.43623676896095276, "2109": 0.2800849378108978, "2220": 0.07793712615966797, "2309": 0.5450005531311035, "2422": 0.011650617234408855, "2470": 0.05046287178993225, "2511": 0.3416208028793335, "2515": 0.34922540187835693, "25... | 17388232 | We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell diffe... | Mechanical regulation of cell function with geometrically modulated elastomeric substrates |
{"1011": 0.12556517124176025, "1043": 0.854249119758606, "1045": 0.8877626657485962, "1050": 0.5381823778152466, "1996": 0.16690383851528168, "2007": 0.056018441915512085, "2029": 0.29109421372413635, "2035": 0.47463157773017883, "2048": 0.4556184411048889, "2050": 0.659380316734314, "2064": 0.08692999184131622, "2066"... | 17402386 | Glutamate-gated ion channels (ionotropic glutamate receptors, iGluRs) sense the extracellular milieu via an extensive extracellular portion, comprised of two clamshell-shaped segments. The distal, N-terminal domain (NTD) has allosteric potential in NMDA-type iGluRs, which has not been ascribed to the analogous domain i... | THE EMBO JOURNAL |
{"1011": 0.15275461971759796, "1051": 1.1115491390228271, "1052": 0.29036402702331543, "1156": 0.1693800985813141, "1999": 0.3034266233444214, "2003": 0.004870930220931768, "2005": 0.13925230503082275, "2006": 0.8433839678764343, "2011": 0.5162794589996338, "2029": 0.19782574474811554, "2063": 0.401551216840744, "2064"... | 17412260 | Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence, activates immune surveillance and paradoxically also has pro-tumorigenic properties. Here, we pr... | A complex secretory program orchestrated by the inflammasome controls paracrine senescence |
{"1003": 0.05046287178993225, "1006": 0.05786345899105072, "1015": 0.3777405619621277, "1023": 0.11951763927936554, "1052": 0.018384648486971855, "1997": 0.37304413318634033, "2015": 0.015504186972975731, "2025": 0.33675122261047363, "2031": 0.3070250153541565, "2038": 0.14518201351165771, "2047": 0.24248650670051575, ... | 17415081 | Over 75% of the annual estimated 9.5 million deaths in India occur in the home, and the large majority of these do not have a certified cause. India and other developing countries urgently need reliable quantification of the causes of death. They also need better epidemiological evidence about the relevance of physical... | Prospective Study of One Million Deaths in India: Rationale, Design, and Validation Results |
{"1011": 0.22704219818115234, "1055": 0.04487626627087593, "1060": 0.34300774335861206, "1996": 0.02316705882549286, "2005": 0.009718249551951885, "2007": 0.15023678541183472, "2011": 0.3601844012737274, "2012": 0.12470348179340363, "2029": 0.0913962796330452, "2071": 0.06795065850019455, "2076": 0.04487626627087593, "... | 17416520 | The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of Bacillus subtilis cells exposed to disulfide stress. Defects in Spx were previously shown to lead to differential expression of numerous genes but direct and indirect regulatory effects could not be distinguished. Here we identif... | Genome-wide identification of genes directly regulated by the pleiotropic transcription factor Spx in Bacillus subtilis |
{"1011": 0.472198486328125, "1014": 0.14939609169960022, "1045": 0.3554046154022217, "1048": 0.1619328260421753, "1052": 0.1734936386346817, "1999": 0.04674193635582924, "2003": 0.040196798741817474, "2004": 0.46486347913742065, "2012": 0.562402069568634, "2021": 0.04113444685935974, "2029": 0.2478361576795578, "2034":... | 17421851 | BACKGROUND Interleukin (IL)-18 is a potent proinflammatory cytokine with potential atherogenic properties. Its expression and role in atherosclerosis, however, are unknown. METHODS AND RESULTS In the present study, we examined stable and unstable human carotid atherosclerotic plaques retrieved by endarterectomy for the... | Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability. |
{"1006": 0.018384648486971855, "1011": 0.3824150264263153, "1043": 0.06520967930555344, "1055": 0.1332872211933136, "1060": 0.7592713832855225, "2000": 0.09584271162748337, "2003": 0.08244366943836212, "2007": 0.3409265875816345, "2011": 0.06154331564903259, "2015": 0.9021284580230713, "2029": 0.12384103983640671, "206... | 17422777 | Size-exclusion chromatography coupled with SAXS (small-angle X-ray scattering), often performed using a flow-through capillary, should allow direct collection of monodisperse sample data. However, capillary fouling issues and non-baseline-resolved peaks can hamper its efficacy. The UltraScan solution modeler (US-SOMO) ... | US-SOMO HPLC-SAXS module: dealing with capillary fouling and extraction of pure component patterns from poorly resolved SEC-SAXS data |
{"1043": 0.3141832649707794, "1050": 0.08692999184131622, "1999": 0.015504186972975731, "2000": 0.06429435312747955, "2001": 0.17840765416622162, "2013": 0.25845035910606384, "2020": 0.1064341589808464, "2035": 0.14602625370025635, "2038": 0.2394166737794876, "2042": 0.28670501708984375, "2043": 0.3662964701652527, "20... | 17433284 | BACKGROUND According to willingness of the Ministry of Health, Iran and presence of appropriate conditions for disease elimination, national malaria control program decided to conduct a research to clarify malaria status in 2007 and to provide required information to perform the elimination program. This review is comp... | Determination of Malaria Epidemiological Status in Iran’s Malarious Areas as Baseline Information for Implementation of Malaria Elimination Program in Iran |
{"1999": 0.06703783571720123, "2012": 0.15359249711036682, "2044": 0.0038986403960734606, "2062": 0.09050461649894714, "2064": 0.19782574474811554, "2070": 0.3005385100841522, "2071": 0.2749055027961731, "2084": 0.10379679501056671, "2087": 0.025073638185858727, "2089": 0.1677299439907074, "2094": 0.21530038118362427, ... | 17438862 | Postmortem immunohistochemical studies have revealed a state of chronic inflammation limited to lesioned areas of brain in Alzheimer’s disease. Some key actors in this inflammation are activated microglia (brain macrophages), proteins of the classical complement cascade, the pentraxins, cytokines, and chemokines. The i... | Local neuroinflammation and the progression of Alzheimer’s disease |
{"1039": 0.05786345899105072, "1050": 0.1619328260421753, "2000": 0.1710275560617447, "2002": 0.6011518239974976, "2003": 0.23092569410800934, "2004": 0.06886265426874161, "2041": 0.18248429894447327, "2046": 0.2247048318386078, "2047": 0.2881702482700348, "2064": 0.4487839937210083, "2075": 0.29400965571403503, "2079"... | 17447653 | BACKGROUND Sequence similarity searching is a very important bioinformatics task. While Basic Local Alignment Search Tool (BLAST) outperforms exact methods through its use of heuristics, the speed of the current BLAST software is suboptimal for very long queries or database sequences. There are also some shortcomings i... | BLAST+: architecture and applications |
{"1017": 0.09050461649894714, "1018": 0.10993985831737518, "1028": 0.03266380727291107, "1043": 0.574020504951477, "1046": 0.21530038118362427, "2020": 0.2018241584300995, "2042": 0.11343330889940262, "2043": 0.04674193635582924, "2052": 0.04394211992621422, "2062": 0.15860503911972046, "2071": 0.35677260160446167, "20... | 17450673 | INTRODUCTION Various perinatal factors, including birth weight, birth order, maternal age, gestational age, twin status, and parental smoking, have been postulated to affect breast cancer risk in daughters by altering the hormonal environment of the developing fetal mammary glands. Despite ample biologic plausibility, ... | Intrauterine environments and breast cancer risk: meta-analysis and systematic review |
{"1011": 0.08692999184131622, "1015": 0.669430673122406, "1016": 0.6619023680686951, "1040": 0.15526613593101501, "2001": 0.49626702070236206, "2013": 0.08871890604496002, "2015": 0.8699195384979248, "2018": 0.014542185701429844, "2020": 0.35128939151763916, "2028": 0.3757305145263672, "2029": 0.02887592278420925, "204... | 17454301 | A small, isolated outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) due to dengue virus type 2 (DEN-2) was documented in Santiago de Cuba on the island of Cuba beginning in January 1997. There were 205 DHF/DSS cases, all in persons older than age 15 years. All but three had evidence of a prior dengue... | Epidemiologic studies on Dengue in Santiago de Cuba, 1997. |
{"1041": 0.5174443125724792, "1047": 1.1702059507369995, "1052": 0.5562619566917419, "1056": 0.4879087805747986, "2007": 0.07793712615966797, "2021": 0.0009760859538801014, "2029": 0.2223619967699051, "2044": 0.16690383851528168, "2045": 0.034552380442619324, "2048": 0.23015019297599792, "2051": 0.1064341589808464, "20... | 17462437 | Clinical implications of KRAS mutations in advanced non-small cell lung cancer remain unclear. We retrospectively evaluated the prognostic and predictive value of KRAS mutations in patients with advanced NSCLC. Among 484 patients with available results for both KRAS and EGFR mutations, 39 (8%) had KRAS and 182 (38%) EG... | Prognostic and Predictive Value of KRAS Mutations in Advanced Non-Small Cell Lung Cancer |
{"1007": 0.07159364968538284, "1047": 0.16276304423809052, "2000": 0.21687394380569458, "2003": 0.06977381557226181, "2007": 0.07341018319129944, "2023": 0.045809537172317505, "2029": 0.10993985831737518, "2043": 0.04207121208310127, "2047": 0.2852376699447632, "2048": 0.38041436672210693, "2059": 0.02792670577764511, ... | 17463469 | This paper presents a parameter covariance matrix estimator which is consistent even when the disturbances of a linear regression model are heteroskedastic. This estimator does not depend on a formal model of the structure of the heteroskedasticity. By comparing the elements of the new estimator to those of the usual c... | A Heteroskedasticity-Consistent Covariance Matrix Estimator And A Direct Test For Heteroskedasticity |
{"1009": 0.41065993905067444, "1044": 0.10906458646059036, "1056": 1.0030416250228882, "2004": 0.00875066313892603, "2015": 0.23479416966438293, "2043": 0.10203468054533005, "2048": 0.17922431230545044, "2064": 0.09850110858678818, "2075": 0.7951818704605103, "2076": 0.6989894509315491, "2096": 0.020300358533859253, "2... | 17463549 | During ageing thymic function declines and is unable to meet the demand for peripheral T helper (Th) cell replenishment. Therefore, population maintenance of naive Th cells must be at least partly peripherally based. Such peripheral postthymic expansion of recent thymic emigrants (RTEs) during ageing consequently shoul... | Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood |
{"1009": 0.4444103240966797, "1015": 0.1229778528213501, "1044": 0.0317181795835495, "1045": 0.6369074583053589, "1052": 0.75193190574646, "1055": 0.8534175157546997, "1058": 0.22859740257263184, "1999": 0.045809537172317505, "2002": 0.7710843086242676, "2007": 0.1384023278951645, "2013": 0.06154331564903259, "2029": 0... | 17464771 | Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gastric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and metaplasia in the mouse stomach. Bacteria producing the less active s... | A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori–Induced Metaplasia in the Stomach |
{"1014": 0.3554046154022217, "1052": 0.5784112811088562, "2005": 0.3982778787612915, "2030": 0.34715715050697327, "2034": 0.2763880789279938, "2043": 0.09938567131757736, "2051": 0.4412745535373688, "2064": 0.0019512200960889459, "2067": 0.151916041970253, "2080": 0.2830325961112976, "2084": 0.24248650670051575, "2086"... | 17482507 | OBJECTIVE To review the evidence for the use of bisphosphonates to reduce skeletal morbidity in cancer patients with bone metastases. DATA SOURCES Electronic databases, scanning reference lists, and consultation with experts and pharmaceutical companies. Foreign language papers were included. STUDY SELECTION Included t... | Systematic review of role of bisphosphonates on skeletal morbidity in metastatic cancer. |
{"1998": 0.10818854719400406, "2003": 0.17759032547473907, "2005": 0.1229778528213501, "2011": 0.15860503911972046, "2015": 0.08871890604496002, "2024": 0.2667117714881897, "2054": 0.04207121208310127, "2066": 0.31845372915267944, "2076": 0.10993985831737518, "2079": 0.09850110858678818, "2089": 0.129004567861557, "210... | 17506075 | Rodent models are an indispensable tool for studying etiology and progress of depression. Since interrelated systems of neurotrophic factors and cytokines comprise major regulatory mechanisms controlling normal brain plasticity, impairments of these systems form the basis for development of cerebral pathologies, includ... | Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers |
{"1011": 0.4041621685028076, "1016": 0.25845035910606384, "1039": 0.3743882179260254, "1044": 0.9021284580230713, "1996": 0.25995752215385437, "1997": 0.12556517124176025, "1999": 0.14518201351165771, "2002": 0.20022670924663544, "2003": 0.06795065850019455, "2010": 1.0560526847839355, "2029": 0.12986256182193756, "204... | 17518195 | Histone variants within the H2A family show high divergences in their C-terminal regions. In this work, we have studied how these divergences and in particular, how a part of the H2A COOH-terminus, the docking domain, is implicated in both structural and functional properties of the nucleosome. Using biochemical method... | The docking domain of histone H2A is required for H1 binding and RSC-mediated nucleosome remodeling |
{"1005": 0.22937409579753876, "1011": 0.31132611632347107, "1015": 0.347847044467926, "1017": 0.8247235417366028, "1996": 0.083342544734478, "1997": 0.16276304423809052, "2008": 0.11691460013389587, "2011": 0.25239890813827515, "2015": 0.37907835841178894, "2028": 0.11604541540145874, "2029": 0.3070250153541565, "2031"... | 17539488 | Several yeast genes produce multiple transcripts with different 3'-ends. Of these, four genes are known to produce truncated transcripts that end within the coding sequence of longer transcripts: CBP1 , AEP2 / ATP13 , RNA14 and SIR1 . It has been shown that the level of the truncated CBP1 transcript increases during th... | Regulation of poly(A) site choice of several yeast mRNAs |
{"1011": 0.3870677351951599, "1021": 0.8083226680755615, "1998": 0.2711893916130066, "2004": 0.053244512528181076, "2006": 0.25088030099868774, "2007": 0.2018241584300995, "2008": 0.0174254160374403, "2015": 0.2990913391113281, "2024": 0.0009760859538801014, "2029": 0.3269403576850891, "2033": 0.16276304423809052, "207... | 17544977 | MicroRNAs (miRNA) play important roles in fine-tuning gene expression and are often deregulated in cancer. The identification of competing endogenous RNA and circular RNA (circRNA) as important regulators of miRNA activity underscores the increasing complexity of ncRNA-mediated regulatory networks. Particularly, the re... | Circular RNA and miR-7 in cancer. |
{"1011": 0.08064348995685577, "1016": 0.058784693479537964, "1052": 0.3262358605861664, "1058": 0.34023189544677734, "2004": 0.3304552733898163, "2011": 0.26146242022514343, "2012": 0.1602703034877777, "2026": 0.8349450826644897, "2029": 0.20818853378295898, "2039": 0.09317722171545029, "2047": 0.053244512528181076, "2... | 17546486 | Skeletal muscle overload induces the expression of angiogenic factors such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-2, leading to new capillary growth. We found that the overload-induced increase in angiogenesis, as well as increases in VEGF, MMP-2 and MT1-MMP transcripts were abr... | Angiotensin II Evokes Angiogenic Signals within Skeletal Muscle through Co-ordinated Effects on Skeletal Myocytes and Endothelial Cells |
{"1011": 0.015504186972975731, "1015": 0.37707099318504333, "1040": 0.3034266233444214, "1049": 0.15359249711036682, "1052": 0.6533012986183167, "1060": 0.7172679901123047, "1999": 0.004870930220931768, "2003": 0.11256109178066254, "2004": 0.11430477350950241, "2008": 0.18978065252304077, "2011": 0.09672962874174118, "... | 17553026 | Human DNA polymerase mu (Polμ) is a family X member that has terminal transferase activity but, in spite of a non-orthodox selection of the template information, displays its maximal catalytic efficiency in DNA-templated reactions. As terminal deoxynucleotidyl transferase (TdT), Polμ has a specific loop (loop1) that co... | A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis |
{"1011": 0.026025565341114998, "1015": 0.3995884954929352, "1039": 1.0560526847839355, "1040": 0.8315495252609253, "1043": 0.3141832649707794, "1050": 0.026025565341114998, "1999": 0.10906458646059036, "2008": 0.18329764902591705, "2011": 0.4286321699619293, "2012": 0.17020416259765625, "2015": 0.007782140281051397, "2... | 17587795 | Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here, we extensively survey diverse species lacking Dnmt1 and show that, surprisingly, symmetrical CG methylation is nonethel... | Dnmt1-Independent CG Methylation Contributes to Nucleosome Positioning in Diverse Eukaryotes |
{"1016": 0.4500300884246826, "1046": 0.3676496744155884, "1048": 0.5718178153038025, "2000": 0.3864043951034546, "2001": 0.15275461971759796, "2003": 0.06246116757392883, "2005": 0.22626367211341858, "2012": 0.19622190296649933, "2020": 0.11081436276435852, "2034": 0.08244366943836212, "2038": 0.012615402229130268, "20... | 17591478 | Effective and tolerable vaccination is an essential strategy to prevent Japanese encephalitis (JE) in endemic areas. Although the live attenuated SA 14-14-2 JE vaccine (LAJEV) has been widely used since its introduction, the systemic data of LAJEV was very rarely available in Korea. We conducted the open-label, prospec... | The Immunogenicity and Safety of the Live-attenuated SA 14-14-2 Japanese Encephalitis Vaccine Given with a Two-dose Primary Schedule in Children |
{"1015": 0.11256109178066254, "1043": 0.684319257736206, "1996": 0.12470348179340363, "1998": 0.11604541540145874, "2004": 0.7105726003646851, "2007": 0.10379679501056671, "2025": 0.27342069149017334, "2028": 0.5540198087692261, "2029": 0.3034266233444214, "2031": 0.0009760859538801014, "2048": 0.07341018319129944, "20... | 17601006 | Many stem cells, including Drosophila germline stem cells (GSCs), divide asymmetrically, producing one stem cell and one differentiating daughter. Cytokinesis is often asymmetric, in that only one daughter cell inherits the midbody ring (MR) upon completion of abscission even in apparently symmetrically dividing cells.... | Centrosome-dependent asymmetric inheritance of the midbody ring in Drosophila germline stem cell division |
{"1003": 0.058784693479537964, "1011": 0.052318159490823746, "1014": 0.5618454217910767, "1040": 0.010684899985790253, "1044": 0.4500300884246826, "1052": 0.6583697199821472, "2001": 0.10026945173740387, "2003": 0.02316705882549286, "2004": 0.09406650811433792, "2005": 0.12814582884311676, "2007": 0.33953672647476196, ... | 17625068 | The aim was to retrospectively determine the real incidence of congenital penile curvature in various forms of hypospadias, in order to indicate intraoperative assessment and correction of curvature. We analyzed 842 patients with hypospadias who underwent surgery from 2003 to 2010, classified into two groups. First gro... | Penile Curvature Incidence in Hypospadias: Can It Be Determined? |
{"1017": 0.15442965924739838, "1041": 0.22157983481884003, "1053": 0.20739519596099854, "1998": 0.026976587250828743, "2000": 0.1685553640127182, "2011": 0.10993985831737518, "2012": 0.5393219590187073, "2020": 0.02887592278420925, "2040": 0.42161011695861816, "2055": 0.040196798741817474, "2058": 0.14264501631259918, ... | 17626822 | BACKGROUND One factor that contributes to high maternal mortality in developing countries is the delayed use of Emergency Obstetric-Care (EmOC) facilities. The objective of this study was to determine the factors that hinder midwives and parturient women from using hospitals when complications occur during home birth i... | Home birth and barriers to referring women with obstetric complications to hospitals: a mixed-methods study in Zahedan, southeastern Iran |
{"1011": 0.2409527748823166, "1017": 0.09672962874174118, "1019": 0.11343330889940262, "1020": 0.6877616047859192, "1041": 0.10291612148284912, "1055": 0.0752234235405922, "1057": 0.6233867406845093, "2005": 0.21135559678077698, "2007": 0.1685553640127182, "2011": 0.4950772523880005, "2012": 0.1477125883102417, "2015":... | 17628888 | Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid disjunction. The Mms21 SUMO ligase docks to the arm region of the S... | ATPase-Dependent Control of the Mms21 SUMO Ligase during DNA Repair |
{"1006": 0.036437395960092545, "1009": 0.7601850032806396, "1011": 0.2539152204990387, "1016": 0.1011524572968483, "1039": 0.07884006202220917, "1040": 0.3283478021621704, "1999": 0.15275461971759796, "2003": 0.35745587944984436, "2005": 0.21135559678077698, "2008": 0.15860503911972046, "2011": 0.036437395960092545, "2... | 17631671 | Cadherins are Ca(2+)-dependent cell-cell adhesion molecules that play critical roles in animal morphogenesis. Various cadherin-related molecules have also been identified, which show diverse functions, not only for the regulation of cell adhesion but also for that of cell proliferation and planar cell polarity. During ... | Cadherins in brain morphogenesis and wiring. |
{"1011": 0.21687394380569458, "1021": 0.25845035910606384, "1038": 0.012615402229130268, "1040": 0.28450319170951843, "1041": 0.5685047507286072, "1059": 1.1512393951416016, "1061": 0.6838265657424927, "1156": 0.6634125709533691, "2007": 0.15860503911972046, "2008": 0.10379679501056671, "2011": 0.38574060797691345, "20... | 17648235 | De-regulation of the wingless and integration site growth factor (WNT) signaling pathway via mutations in APC and Axin, proteins that target β-catenin for destruction, have been linked to various types of human cancer. These genetic alterations rarely, if ever, are observed in breast tumors. However, various lines of e... | Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation |
{"1011": 0.39696553349494934, "1014": 0.41195443272590637, "1015": 0.34922540187835693, "1018": 0.46055975556373596, "1019": 0.7086513638496399, "1037": 0.35403475165367126, "1042": 0.07341018319129944, "1043": 0.7610978484153748, "1053": 0.18329764902591705, "1997": 0.007782140281051397, "1998": 0.011650617234408855, ... | 17656445 | OBJECTIVE Fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG) are of interest for monitoring short-term glycemic control in patients with diabetes; however, their associations with diabetes risk are uncharacterized. RESEARCH DESIGN AND METHODS We used Cox proportional hazards models to examine the associat... | Alternative Markers of Hyperglycemia and Risk of Diabetes |
{"1011": 0.28082266449928284, "1044": 0.034552380442619324, "1054": 0.3423145115375519, "1060": 0.48430517315864563, "1157": 0.7314660549163818, "1998": 0.8649974465370178, "2004": 0.08603433519601822, "2005": 0.021256839856505394, "2011": 0.1808556467294693, "2029": 0.28082266449928284, "2036": 0.1332872211933136, "20... | 17671145 | The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined. Here we show that retinoic acid receptor-related orphan receptor γ (ROR-γ) is overexpressed and amplified in metastatic CRPC tum... | ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer |
{"1011": 0.05970508232712746, "1042": 0.2659635543823242, "1054": 0.9754437208175659, "1060": 0.0019512200960889459, "2003": 0.45870962738990784, "2005": 0.176772341132164, "2064": 0.02412080205976963, "2109": 0.2652147710323334, "2117": 0.15023678541183472, "2207": 0.2696990668773651, "2224": 0.04487626627087593, "236... | 17676273 | MOTIVATION The processing of the Affymetrix GeneChip data has been a recent focus for data analysts. Alternatives to the original procedure have been proposed and some of these new methods are widely used. RESULTS The affy package is an R package of functions and classes for the analysis of oligonucleotide arrays manuf... | affy--analysis of Affymetrix GeneChip data at the probe level. |
{"1001": 0.30989447236061096, "1009": 0.4286321699619293, "1011": 0.39367714524269104, "1017": 0.1011524572968483, "1019": 0.036437395960092545, "1023": 0.36426326632499695, "1043": 0.7500885725021362, "1048": 0.32129061222076416, "1056": 1.0512858629226685, "1058": 0.12814582884311676, "1062": 0.7124901413917542, "199... | 17682477 | To test the feasibility of a single T-cell manipulation to eliminate alloreactivity while sparing antiviral and antitumor T cells, we infused 12 haploidentical hematopoietic stem cell transplant patients with increasing numbers of alloreplete haploidentical T cells expressing the inducible caspase 9 suicide gene (iC9-T... | Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation. |
{"1020": 0.32270604372024536, "1021": 0.22548456490039825, "1996": 0.012615402229130268, "1999": 0.05046287178993225, "2001": 0.1808556467294693, "2004": 0.0770333781838417, "2011": 0.10379679501056671, "2012": 0.1873544454574585, "2013": 0.3877306580543518, "2019": 0.2881702482700348, "2020": 0.3547199070453644, "2029... | 17685207 | The fate of cells in the epiblast at prestreak and early primitive streak stages has been studied by injecting horseradish peroxidase (HRP) into single cells in situ of 6.7-day mouse embryos and identifying the labelled descendants at midstreak to neural plate stages after one day of culture. Ectoderm was composed of d... | Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. |
{"1018": 0.18248429894447327, "1020": 0.04394211992621422, "1021": 0.1064341589808464, "1044": 0.16690383851528168, "1998": 0.0354953333735466, "2007": 0.043007105588912964, "2015": 0.20022670924663544, "2044": 0.32270604372024536, "2076": 0.0019512200960889459, "2090": 0.5162794589996338, "2109": 0.034552380442619324,... | 17691617 | OBJECTIVES To investigate the effects of a high-intensity functional exercise program on independence in activities of daily living (ADLs) and balance in older people with dementia and whether exercise effects differed between dementia types. DESIGN Cluster-randomized controlled trial: Umeå Dementia and Exercise (UMDEX... | Effects of a High-Intensity Functional Exercise Program on Dependence in Activities of Daily Living and Balance in Older Adults with Dementia |
{"1011": 0.18816383183002472, "1014": 0.36426326632499695, "1020": 0.012615402229130268, "1045": 0.7105726003646851, "1052": 0.49923527240753174, "1053": 0.3077431619167328, "1997": 0.2976420819759369, "2001": 0.0029254043474793434, "2086": 0.22937409579753876, "2090": 0.31560876965522766, "2094": 0.6793810129165649, "... | 17693849 | BACKGROUND Appropriate understanding of health information by patients with cardiovascular disease (CVD) is fundamental for better management of risk factors and improved morbidity, which can also benefit their quality of life. OBJECTIVES To assess the relationship between health literacy and health-related quality of ... | Effect of Health Literacy on Quality of Life amongst Patients with Ischaemic Heart Disease in Australian General Practice |
{"1009": 0.6400018334388733, "1011": 0.03925827145576477, "1016": 0.9842413663864136, "1043": 0.26446542143821716, "1050": 0.27712854743003845, "1056": 1.1512393951416016, "2003": 0.24248650670051575, "2008": 0.1477125883102417, "2011": 0.14686977863311768, "2029": 0.17431432008743286, "2046": 0.24171993136405945, "204... | 17695748 | Transglutaminase 2 (TGase 2) is a Ca+2-dependent enzyme that catalyzes both intracellular and extracellular cross-linking reactions by transamidation of specific glutamine residues. TGase 2 is known to be involved in the membrane-mediated events required for glucose-stimulated insulin release from the pancreatic beta c... | in |
{"1017": 0.16524957120418549, "1041": 0.4374985992908478, "1043": 0.11951763927936554, "1044": 0.22859740257263184, "1998": 0.31845372915267944, "2007": 0.00875066313892603, "2008": 0.010684899985790253, "2010": 0.4500300884246826, "2015": 0.5596157908439636, "2029": 0.29473719000816345, "2031": 0.1685553640127182, "20... | 17702490 | Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested that ESCs and iPSCs ... | Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. |
{"1009": 0.6568518877029419, "1011": 0.23247487843036652, "1015": 0.27044451236724854, "1054": 0.9100211262702942, "1055": 0.0038986403960734606, "1058": 0.3027053773403168, "1999": 0.23710809648036957, "2012": 0.23710809648036957, "2013": 0.18978065252304077, "2026": 0.950843095779419, "2029": 0.19782574474811554, "20... | 17708753 | Whilst data recognise both myeloid cell accumulation during choroidal neovascularisation (CNV) as well as complement activation, none of the data has presented a clear explanation for the angiogenic drive that promotes pathological angiogenesis. One possibility that is a pre-eminent drive is a specific and early condit... | Myeloid Cells Expressing VEGF and Arginase-1 Following Uptake of Damaged Retinal Pigment Epithelium Suggests Potential Mechanism That Drives the Onset of Choroidal Angiogenesis in Mice |
{"1009": 0.49626702070236206, "1018": 0.5450005531311035, "1052": 1.1128336191177368, "2007": 0.11256109178066254, "2008": 0.13414156436920166, "2011": 0.0797421783208847, "2029": 0.27786844968795776, "2035": 0.3949938118457794, "2050": 0.6296497583389282, "2076": 0.034552380442619324, "2109": 0.034552380442619324, "21... | 17717391 | Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16(LUC)), which faithfully reports expression of p16(INK4a), a tumor suppressor and aging biomarker. Lifelong assessment of luminescence in p16(+/LUC) mice revealed an exponential increase with aging, ... | Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model |
{"1011": 0.15943801403045654, "1015": 0.5092619061470032, "1017": 0.08692999184131622, "1019": 0.3560888469219208, "1042": 0.24018502235412598, "1043": 0.21687394380569458, "1052": 0.38905516266822815, "1054": 0.39762192964553833, "2002": 1.0506030321121216, "2003": 0.25845035910606384, "2013": 0.021256839856505394, "2... | 17731780 | ScPif1 DNA helicase is the prototypical member of a 5'-to-3' helicase superfamily conserved from bacteria to human and plays various roles in the maintenance of genomic homeostasis. While many studies have been performed with eukaryotic Pif1 helicases, including yeast and human Pif1 proteins, the potential functions an... | The Bacteroides sp. 3_1_23 Pif1 protein is a multifunctional helicase |
{"1011": 0.12470348179340363, "1017": 0.13071982562541962, "1055": 0.23247487843036652, "1058": 0.5104349255561829, "2003": 0.2576959431171417, "2007": 0.06795065850019455, "2011": 0.37304413318634033, "2019": 0.906871497631073, "2026": 0.5104349255561829, "2029": 0.259204238653183, "2061": 0.12986256182193756, "2076":... | 17741440 | Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and m... | Netting neutrophils in autoimmune small-vessel vasculitis |
{"1043": 0.4794800877571106, "1047": 0.5871354341506958, "1052": 0.9687942266464233, "1062": 0.23247487843036652, "1160": 0.0354953333735466, "2005": 0.20977331697940826, "2029": 0.2145126610994339, "2037": 0.013579257763922215, "2048": 0.25088030099868774, "2063": 0.056018441915512085, "2076": 0.020300358533859253, "2... | 17755060 | Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We show that PKCζ deficiency promotes the plasticity necessary for cancer cells to reprogram their metabolism to utilize glutamine through the seri... | Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis |
{"1011": 0.3084607720375061, "1018": 0.46486347913742065, "1052": 0.436867892742157, "1058": 0.28743788599967957, "1060": 1.057410478591919, "1998": 0.4093637466430664, "1999": 0.12642613053321838, "2004": 0.07068414986133575, "2005": 0.30558720231056213, "2007": 0.46608972549438477, "2008": 0.12038381397724152, "2011"... | 17768946 | XRCC4 and XLF are structurally related proteins important for DNA Ligase IV function. XRCC4 forms a tight complex with DNA Ligase IV while XLF interacts directly with XRCC4. Both XRCC4 and XLF form homodimers that can polymerize as heterotypic filaments independently of DNA Ligase IV. Emerging structural and in vitro b... | XRCC4's interaction with XLF is required for coding (but not signal) end joining |
{"1011": 0.009718249551951885, "1016": 0.2493593990802765, "1017": 0.030771657824516296, "1040": 0.6415454745292664, "1044": 0.6000806093215942, "1045": 0.8500841856002808, "2004": 0.06246116757392883, "2008": 0.08961215615272522, "2025": 0.347847044467926, "2029": 0.2409527748823166, "2035": 0.401551216840744, "2061":... | 17775228 | Epigenetic alterations in human cancers include global DNA hypomethylation,gene hypomethylation and promoter hypermethylation, and loss of imprinting (LOI) of the insulin-like growth factor-II gene (IGF2). A mechanism for LOI described previously is hypermethylation of a differentially methylated region (DMR) upstream ... | Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. |
{"1011": 0.02887592278420925, "1043": 0.48610860109329224, "2001": 0.0354953333735466, "2005": 0.11517547070980072, "2006": 0.14686977863311768, "2007": 0.32553088665008545, "2009": 0.09584271162748337, "2020": 0.10203468054533005, "2048": 0.2763880789279938, "2053": 0.46853771805763245, "2079": 0.004870930220931768, "... | 17779800 | OBJECTIVE To explore how a group of Swedish general practitioners (GPs) manage patients with a sore throat in relation to current guidelines as expressed in interviews. DESIGN Qualitative content analysis was used to analyse semi-structured interviews. SETTING Swedish primary care. SUBJECTS A strategic sample of 25 GPs... | Management of patients with sore throats in relation to guidelines: An interview study in Sweden |
{"1996": 0.304147332906723, "2006": 0.09672962874174118, "2011": 0.4709797203540802, "2012": 0.22157983481884003, "2015": 0.1889725625514984, "2029": 0.15610189735889435, "2043": 0.13755162060260773, "2059": 0.21687394380569458, "2070": 0.12642613053321838, "2076": 0.7086513638496399, "2079": 0.259204238653183, "2089":... | 17805221 | Sport fishermen keep tension on their lines to prevent hooked fish from releasing. A molecular version of this angler's trick, operating at kinetochores, ensures accuracy during mitosis: the mitotic spindle attaches randomly to chromosomes and then correctly bioriented attachments are stabilized due to the tension exer... | Catch and release: how do kinetochores hook the right microtubules during mitosis? |
{"1011": 0.00875066313892603, "1042": 0.1710275560617447, "2000": 0.1889725625514984, "2003": 0.0174254160374403, "2005": 0.04113444685935974, "2026": 1.1070401668548584, "2033": 0.3077431619167328, "2057": 0.8829278349876404, "2064": 0.3177432417869568, "2073": 0.2317005842924118, "2109": 0.3883931338787079, "2112": 0... | 17814815 | We report a newly developed technique for high-resolution in vivo imaging of myelinated axons in the brain, spinal cord and peripheral nerve that requires no fluorescent labeling. This method, based on spectral confocal reflectance microscopy (SCoRe), uses a conventional laser-scanning confocal system to generate image... | Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy |
{"1003": 0.3248254358768463, "1011": 0.3910386264324188, "1016": 0.020300358533859253, "1019": 0.18978065252304077, "1020": 0.49626702070236206, "1045": 0.03360854089260101, "1052": 0.022212404757738113, "1055": 0.3622259199619293, "1155": 0.4487839937210083, "1997": 0.04953393340110779, "1999": 0.043007105588912964, "... | 17821387 | In Parkinson's disease (PD) and dementia with Lewy bodies (DLB) alpha-synuclein (alphaS) pathology is seen that displays a predictable topographic distribution. There are two staging/categorization systems, i.e. Braak's and McKeith's, currently in use for the assessment of alphaS pathology. The aim of these diagnostic ... | Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance |
{"1011": 0.34577593207359314, "1016": 0.36697331070899963, "1018": 0.6960725784301758, "1042": 0.6619023680686951, "1056": 0.9769153594970703, "2005": 0.11517547070980072, "2008": 0.056018441915512085, "2011": 0.16690383851528168, "2012": 0.757441520690918, "2024": 0.07793712615966797, "2029": 0.2689530849456787, "2035... | 17829012 | Apart from T helper (Th)-2 cells, T follicular helper (Tfh) cells are a major class of IL-4-producing T cells, required for regulation of type 2 humoral immunity; however, transcriptional control of IL-4 production in Tfh cells remains mainly unknown. Here, we show that the basic leucine zipper transcription factor ATF... | Batf is important for IL-4 expression in T follicular helper cells |
{"1011": 0.052318159490823746, "1015": 0.04487626627087593, "1019": 0.3318578004837036, "1041": 0.7124901413917542, "1043": 0.34508460760116577, "1047": 0.7881022095680237, "1058": 0.7134475708007812, "1999": 0.06246116757392883, "2005": 0.28670501708984375, "2006": 0.2105647772550583, "2008": 0.056018441915512085, "20... | 17844478 | It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for tumor cell proliferation in a cell-autonomous and angiogenesis-independent manner. VEGF is upregulated in SOS... | Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development |
{"1015": 0.23864774405956268, "1017": 0.09850110858678818, "1052": 0.5010119676589966, "1060": 0.3777405619621277, "2000": 0.04674193635582924, "2004": 0.036437395960092545, "2005": 0.17759032547473907, "2006": 0.04953393340110779, "2007": 0.2516399025917053, "2026": 0.5261374711990356, "2028": 0.03831886500120163, "20... | 17876040 | Owing to their integral involvement in cell cycle regulation, the Polo-like kinase (Plk) family, particularly Plk1, has emerged as an attractive therapeutic target in oncology. In recent years, several Plk1 inhibitors have been developed, with some agents showing encouraging results in early-phase clinical trials. This... | Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy |
{"2000": 0.0842406153678894, "2003": 0.34577593207359314, "2005": 0.19381128251552582, "2007": 0.22704219818115234, "2025": 0.014542185701429844, "2043": 0.2976420819759369, "2048": 0.09584271162748337, "2051": 0.15359249711036682, "2052": 0.14939609169960022, "2058": 0.21214580535888672, "2064": 0.44566190242767334, "... | 17877537 | Self-generated mobility via locomotion is a key for the cognitive, social and motor development of young infants. For certain children with special needs, self-generated mobility is only attained via assistive technology such as a power wheelchair. Up until recently, infants under 24 months of age were not considered c... | Babies driving robots: self-generated mobility in very young infants |
{"1011": 0.22001366317272186, "1014": 0.2689530849456787, "1017": 0.22937409579753876, "1040": 0.19862671196460724, "1043": 0.2493593990802765, "1052": 0.18573370575904846, "1060": 0.06429435312747955, "1998": 0.007782140281051397, "1999": 0.34370049834251404, "2002": 0.5784112811088562, "2004": 0.8272887468338013, "20... | 17897801 | BACKGROUND Abciximab plus aspirin improves the TIMI 3 flow rate of the infarct-related artery in patients treated with either percutaneous coronary intervention or thrombolysis. The present study investigated whether the reperfusion efficacy of abciximab relates to modifications of clot architecture in patients admitte... | Effects of Abciximab on the architecture of platelet-rich clots in patients with acute myocardial infarction undergoing primary coronary intervention. |
{"1011": 0.09317722171545029, "1015": 0.4132472574710846, "1048": 0.8941729068756104, "1997": 0.07250232994556427, "1999": 0.06154331564903259, "2011": 0.32764431834220886, "2012": 0.2531573474407196, "2013": 0.026976587250828743, "2015": 0.34300774335861206, "2028": 0.20580662786960602, "2029": 0.22937409579753876, "2... | 17911973 | Two abundant classes of mobile elements, namely Alu and L1 elements, continue to generate new retrotransposon insertions in human genomes. Estimates suggest that these elements have generated millions of new germline insertions in individual human genomes worldwide. Unfortunately, current technologies are not capable o... | Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons |
{"1014": 0.1064341589808464, "1038": 0.48068851232528687, "1039": 0.3034266233444214, "1040": 0.0009760859538801014, "1054": 0.32764431834220886, "1058": 0.15860503911972046, "1998": 0.13755162060260773, "2000": 0.06154331564903259, "2001": 0.0038986403960734606, "2020": 0.026025565341114998, "2031": 0.0298242401331663... | 17914395 | BACKGROUND African Americans have higher rates of cardiovascular disease (CVD) mortality than other ethnic groups. Young adults are prime targets for intervention strategies to prevent and reduce disease risk. The study purpose was to determine the level of knowledge of lifestyle risk factors for CVD among young Africa... | Knowledge of young African American adults about heart disease: a cross-sectional survey |
{"1011": 0.083342544734478, "1996": 0.0913962796330452, "1999": 0.04394211992621422, "2006": 0.319873183965683, "2011": 0.3910386264324188, "2029": 0.151916041970253, "2033": 0.43244171142578125, "2064": 0.2247048318386078, "2076": 0.2247048318386078, "2079": 0.24171993136405945, "2083": 0.052318159490823746, "2109": 0... | 17917408 | Members of the Notch family of transmembrane receptors play an important role in cell fate determination. Over the past decade, a role for Notch in the pathogenesis of hematologic and solid malignancies has become apparent. Numerous cellular functions and microenvironmental cues associated with tumorigenesis are modula... | Recent insights into the role of Notch signaling in tumorigenesis |
{"1011": 0.03925827145576477, "1048": 0.7592713832855225, "1050": 0.5762182474136353, "1996": 0.08513788133859634, "1997": 0.1332872211933136, "1999": 0.21214580535888672, "2002": 0.2652147710323334, "2003": 0.09938567131757736, "2010": 1.0920805931091309, "2011": 0.11081436276435852, "2012": 0.3963087201118469, "2029"... | 17919731 | Genetic information is packaged in the highly dynamic nucleoprotein structure called chromatin. Many biological processes are regulated via post-translational modifications of key proteins. Acetylation of lysine residues at the N-terminal histone tails is one of the most studied covalent modifications influencing gene ... | BRIEFINGS IN FUNCTIONAL GENOMICS AND PROTEOMICS. VOL 5. NO 3. 209^221 doi:10.1093/bfgp/ell028 Histone acetylation in gene regulation |
{"1020": 0.10291612148284912, "1052": 0.7426811456680298, "1056": 0.14349138736724854, "2005": 0.6176109313964844, "2029": 0.08871890604496002, "2043": 0.0354953333735466, "2051": 0.20421554148197174, "2063": 0.38374659419059753, "2076": 0.17267228662967682, "2078": 0.013579257763922215, "2080": 0.4337083101272583, "20... | 17925632 | We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind, placebo-controlled study, 205 Thai soldiers received either a loading dose of tafenoquine 400 mg (base) daily for 3 days, followed by single monthly 400-mg doses (n = 10... | Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malaria. |
{"1014": 0.503966212272644, "1017": 0.16110190749168396, "1044": 0.3034266233444214, "1052": 0.37304413318634033, "1999": 0.6425731778144836, "2007": 0.3683255612850189, "2011": 0.17840765416622162, "2015": 0.00875066313892603, "2053": 0.045809537172317505, "2069": 0.4494072198867798, "2075": 0.49030399322509766, "2090... | 17930286 | OBJECTIVE To evaluate the association of overall and specific headaches with volume of white matter hyperintensities, brain infarcts, and cognition. DESIGN Population based, cross sectional study. SETTING Epidemiology of Vascular Ageing study, Nantes, France. PARTICIPANTS 780 participants (mean age 69, 58.5% women) wit... | Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing-MRI study |
{"1009": 0.0797421783208847, "1011": 0.23402166366577148, "2001": 0.018384648486971855, "2007": 0.08513788133859634, "2011": 0.00875066313892603, "2012": 0.0058422754518687725, "2013": 0.26296505331993103, "2020": 0.1734936386346817, "2024": 0.03360854089260101, "2026": 0.5607312321662903, "2029": 0.10026945173740387, ... | 17933691 | A population of fibro/adipogenic but non-myogenic progenitors located between skeletal muscle fibers was recently discovered. The aim of this study was to determine the extent to which these progenitors differentiate into fully functional adipocytes. The characterization of muscle progenitor-derived adipocytes is a cen... | Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle |
{"1996": 0.15023678541183472, "1999": 0.9827804565429688, "2003": 0.3127557039260864, "2006": 0.5947071313858032, "2008": 0.1221139207482338, "2011": 0.319873183965683, "2024": 0.46853771805763245, "2029": 0.13670019805431366, "2063": 0.02412080205976963, "2066": 0.09850110858678818, "2073": 0.025073638185858727, "2075... | 17934082 | Invadopodia are extracellular matrix (ECM)-degrading protrusions formed by invasive cancer cells. Podosomes are structures functionally similar to invadopodia that are found in oncogene-transformed fibroblasts and monocyte-derived cells, including macrophages and osteoclasts. These structures are thought to play import... | Membrane lipids in invadopodia and podosomes: Key structures for cancer invasion and metastasis |
{"1016": 0.3824150264263153, "1039": 0.4462870955467224, "1048": 0.39367714524269104, "1054": 0.3297532796859741, "1999": 0.043007105588912964, "2005": 0.1212492436170578, "2007": 0.129004567861557, "2011": 0.13925230503082275, "2029": 0.083342544734478, "2044": 0.02316705882549286, "2064": 0.1485546976327896, "2079": ... | 17934603 | BACKGROUND CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease. METHODS Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharmacodynamic consequences... | CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis |
{"1011": 0.06612417846918106, "1017": 0.05694137513637543, "1018": 0.42735910415649414, "1040": 0.38374659419059753, "1041": 0.36086538434028625, "1056": 0.7610978484153748, "2002": 0.935633659362793, "2004": 0.06246116757392883, "2005": 0.1808556467294693, "2007": 0.16359257698059082, "2011": 0.11343330889940262, "202... | 17939443 | Bacteriophage T4 Dda helicase has recently been shown to be active as a monomer for unwinding of short duplex oligonucleotides and for displacing streptavidin from 3′-biotinylated oligonucleotides. However, its activity for streptavidin displacement and DNA unwinding has been shown to increase as the number of Dda mole... | Displacement of a DNA binding protein by Dda helicase |
{"1016": 0.4400174915790558, "1052": 0.36900100111961365, "1062": 0.15610189735889435, "1996": 0.09317722171545029, "2005": 0.29255300760269165, "2008": 0.12986256182193756, "2010": 0.732405424118042, "2011": 0.2409527748823166, "2024": 0.034552380442619324, "2029": 0.26296505331993103, "2043": 0.09850110858678818, "20... | 17945638 | Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2) subunit SUZ12 across the entire nonrepeat portion of the genome in human embryonic stem (ES) cells. We found that SUZ12 ... | Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells |
{"1009": 0.574020504951477, "1011": 0.02792670577764511, "1018": 0.6654226183891296, "1044": 0.2447827309370041, "1999": 0.13157635927200317, "2005": 0.23092569410800934, "2010": 0.9783848524093628, "2011": 0.46853771805763245, "2015": 0.18411032855510712, "2029": 0.21372433006763458, "2049": 0.13414156436920166, "2062... | 17967608 | Neutrophils trap and kill bacteria by forming highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs). We previously reported that histone hypercitrullination catalyzed by peptidylarginine deiminase 4 (PAD4) correlates with chromatin decondensation during NET formation. However, the role o... | PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps |
{"1011": 0.2689530849456787, "1015": 0.6038249135017395, "1044": 0.48670899868011475, "1999": 0.1685553640127182, "2003": 0.036437395960092545, "2008": 0.04207121208310127, "2011": 0.1602703034877777, "2028": 0.22626367211341858, "2029": 0.2667117714881897, "2039": 0.23633737862110138, "2046": 0.3318578004837036, "2063... | 17973161 | Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is also found outside classical brown adipose tissue depots, in adipocytes that are termed 'brite' (brown-in-white) or 'beige'. In humans, the presence of brite or ... | Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice |
{"1014": 0.3464667797088623, "1019": 0.11691460013389587, "1020": 0.18004031479358673, "1022": 0.23402166366577148, "1026": 0.20421554148197174, "1050": 0.7086513638496399, "1052": 0.3163207769393921, "1053": 0.007782140281051397, "1164": 0.4437839686870575, "2000": 0.009718249551951885, "2005": 0.10026945173740387, "2... | 17973630 | IMPORTANCE Sleep disturbances are most prevalent among older adults and often go untreated. Treatment options for sleep disturbances remain limited, and there is a need for community-accessible programs that can improve sleep. OBJECTIVE To determine the efficacy of a mind-body medicine intervention, called mindfulness ... | Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. |
{"1996": 0.32058215141296387, "1997": 0.016465263441205025, "2008": 0.006812678650021553, "2011": 0.10026945173740387, "2013": 0.5506471395492554, "2015": 0.1970241367816925, "2024": 0.0770333781838417, "2029": 0.10906458646059036, "2031": 0.020300358533859253, "2033": 0.5784112811088562, "2034": 0.08692999184131622, "... | 17991818 | Some authors claim that microglia originate from the neuroepithelium, although most now believe that microglial cells are of mesodermal origin, and probably belong to the monocyte/macrophage cell line. These cells must enter the developing central nervous system (CNS) from the blood stream, the ventricular space or the... | THE ORIGIN AND DIFFERENTIATION OF MICROGLIAL CELLS DURING DEVELOPMENT |
{"1011": 0.1710275560617447, "1043": 0.09228714555501938, "1054": 0.06520967930555344, "1056": 1.0533316135406494, "1155": 0.45932671427726746, "1156": 0.8057082891464233, "2011": 0.30989447236061096, "2029": 0.17840765416622162, "2043": 0.058784693479537964, "2076": 0.6862877607345581, "2079": 0.23787821829319, "2099"... | 17997584 | Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during inflammation is unclear. Here we show that effector Treg cells express high amounts of the integrin αvβ8, which enables them to act... | Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation |
{"1014": 0.3070250153541565, "1062": 0.1602703034877777, "2039": 0.09672962874174118, "2086": 0.2501201331615448, "2088": 0.25694093108177185, "2095": 0.3519764244556427, "2116": 0.1485546976327896, "2146": 0.1734936386346817, "2172": 0.24325250089168549, "2173": 0.6233867406845093, "2177": 0.44691193103790283, "2184":... | 18025240 | OBJECTIVE To summarise the effects of anthelmintic drug treatment on growth and cognitive performance in children. DATA SOURCES Electronic databases: Cochrane Infectious Diseases Group controlled trial register, Cochrane controlled trials register, Embase, and Medline. Citations of all identified trials. Contact with t... | Effects of treatment for intestinal helminth infection on growth and cognitive performance in children: systematic review of randomised trials. |
{"1011": 0.1212492436170578, "1018": 0.19381128251552582, "1039": 0.20421554148197174, "1998": 0.006812678650021553, "1999": 0.0029254043474793434, "2005": 0.10993985831737518, "2011": 0.11604541540145874, "2015": 0.28963330388069153, "2028": 0.24631060659885406, "2029": 0.20421554148197174, "2046": 0.05139094591140747... | 18027063 | Although phylogenetic inference of protein-coding sequences continues to dominate the literature, few analyses incorporate evolutionary models that consider the genetic code. This problem is exacerbated by the exclusion of codon-based models from commonly employed model selection techniques, presumably due to the compu... | Choosing appropriate substitution models for the phylogenetic analysis of protein-coding sequences. |
{"1011": 0.04860413447022438, "1015": 0.1970241367816925, "1052": 0.2539152204990387, "1997": 0.013579257763922215, "2002": 0.0606246218085289, "2005": 0.1751343309879303, "2010": 0.9583619832992554, "2011": 0.1477125883102417, "2014": 0.7629209756851196, "2016": 0.07884006202220917, "2043": 0.02792670577764511, "2049"... | 18037805 | The transcriptional status of a gene can be maintained through multiple rounds of cell division during development. This epigenetic effect is believed to reflect heritable changes in chromatin folding and histone modifications or variants at target genes, but little is known about how these chromatin features are inher... | Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro |
{"1011": 0.34922540187835693, "1016": 0.7134475708007812, "1043": 0.6734226942062378, "1055": 0.04860413447022438, "2015": 0.1064341589808464, "2029": 0.04487626627087593, "2048": 0.35334911942481995, "2071": 0.1332872211933136, "2076": 0.44753631949424744, "2079": 0.0019512200960889459, "2084": 0.15693697333335876, "2... | 18038250 | Within the developing mammalian CNS, growth factors direct multipotent precursors to generate neurons versus glia, a process that if perturbed might lead to neural dysfunction. In this regard, genetic mutations resulting in constitutive activation of the protein tyrosine phosphatase SHP-2 cause Noonan Syndrome (NS), wh... | Control of CNS Cell-Fate Decisions by SHP-2 and Its Dysregulation in Noonan Syndrome |
{"1011": 0.1930064558982849, "1022": 0.28082266449928284, "1044": 0.4831010699272156, "1051": 0.47827014327049255, "1062": 1.2187074422836304, "1999": 1.1211429834365845, "2003": 0.3560888469219208, "2004": 0.026976587250828743, "2005": 0.18816383183002472, "2008": 0.23324857652187347, "2010": 0.7701805830001831, "2011... | 18038955 | INO80 is an evolutionarily conserved, ATP-dependent chromatin-remodeling enzyme that plays roles in transcription, DNA repair, and replication. Here, we show that yeast INO80 facilitates these diverse processes at least in part by controlling genome-wide distribution of the histone variant H2A.Z. In the absence of INO8... | Global Regulation of H2A.Z Localization by the INO80 Chromatin-Remodeling Enzyme Is Essential for Genome Integrity |
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