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{"1011": 0.009718249551951885, "1038": 0.49982786178588867, "1043": 0.3141832649707794, "1054": 1.0492360591888428, "1996": 0.0317181795835495, "2005": 0.07884006202220917, "2008": 0.06886265426874161, "2029": 0.371698260307312, "2035": 0.38905516266822815, "2037": 0.19862671196460724, "2050": 0.2160874605178833, "2063... | 18041692 | Cells migrate in multiple different ways depending on their environment, which includes the extracellular matrix composition, interactions with other cells, and chemical stimuli. For all types of cell migration, Rho GTPases play a central role, although the relative contribution of each Rho GTPase depends on the enviro... | Rho GTPase signalling in cell migration |
{"1011": 0.19381128251552582, "1016": 0.371698260307312, "1039": 0.17267228662967682, "1056": 0.9769153594970703, "1996": 0.058784693479537964, "2007": 0.2786078155040741, "2011": 0.5139457583427429, "2029": 0.0797421783208847, "2075": 0.5690577030181885, "2076": 0.10026945173740387, "2078": 0.02887592278420925, "2079"... | 18042803 | Recognition of antigen by T cells requires the formation of a specialized junction between the T cell and the antigen-presenting cell. This junction is generated by the recruitment and the exclusion of specific proteins from the contact area. The mechanisms that regulate these events are unknown. Here we demonstrate th... | A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts |
{"1011": 0.02887592278420925, "1014": 0.5773153901100159, "1016": 0.08603433519601822, "1019": 0.2652147710323334, "1052": 0.7144040465354919, "1056": 0.04113444685935974, "2001": 0.11778303235769272, "2002": 0.2145126610994339, "2004": 0.8517522215843201, "2005": 0.14939609169960022, "2010": 0.7969439625740051, "2013"... | 18062308 | STUDY OBJECTIVE We assessed whether transpleural methods for diagnosing peripheral lung cancer, such as needle aspiration or tumor excision, affect relapse and prognosis, because these techniques have potential to spread malignant cells from the tumor. DESIGN A retrospective study. SETTING National referral hospital. P... | Operable non-small cell lung cancer diagnosed by transpleural techniques : do they affect relapse and prognosis? |
{"1006": 0.016465263441205025, "1009": 0.5618454217910767, "1011": 0.2749055027961731, "1155": 0.3127557039260864, "1999": 0.02316705882549286, "2004": 0.21765978634357452, "2008": 0.0354953333735466, "2011": 0.20501139760017395, "2013": 0.28670501708984375, "2015": 0.016465263441205025, "2024": 0.034552380442619324, "... | 18064113 | Mature adipocytes are generated through the proliferation and differentiation of precursor cells. Our previous studies identified adipocyte progenitors in white adipose tissue (WAT) as Lin(-):CD29(+):CD34(+):Sca-1(+):CD24(+) (CD24(+)) cells that are capable of generating functional WAT (ref. ). Here, we employ several... | Characterization of the adipocyte cellular lineage in vivo |
{"1003": 0.30558720231056213, "1015": 0.03266380727291107, "1017": 0.306306391954422, "1020": 0.4709797203540802, "1041": 0.7836518287658691, "1052": 0.13670019805431366, "1999": 0.38174858689308167, "2000": 0.2852376699447632, "2004": 0.4770587682723999, "2005": 0.08603433519601822, "2007": 0.10555581003427505, "2011"... | 18074797 | BACKGROUND Over the past decade malaria intervention coverage has been scaled up across Africa. However, it remains unclear what overall reduction in transmission is achievable using currently available tools. METHODS AND FINDINGS We developed an individual-based simulation model for Plasmodium falciparum transmission ... | Reducing Plasmodium falciparum Malaria Transmission in Africa: A Model-Based Evaluation of Intervention Strategies |
{"1011": 0.2231435477733612, "1015": 0.40285754203796387, "1016": 0.15526613593101501, "1047": 0.5415972471237183, "1996": 0.3676496744155884, "2004": 0.17431432008743286, "2008": 0.13670019805431366, "2011": 0.06795065850019455, "2012": 0.24248650670051575, "2013": 0.17431432008743286, "2028": 0.03360854089260101, "20... | 18078750 | Mechanisms that are responsible for sorting newly synthesized proteins for traffic to the cell surface from the Golgi are poorly understood. Here, we show that the potassium channel Kir2.1, mutations in which are associated with Andersen-Tawil syndrome, is selected as cargo into Golgi export carriers in an unusual sign... | Golgi Export of the Kir2.1 Channel Is Driven by a Trafficking Signal Located within Its Tertiary Structure |
{"1013": 0.2184450328350067, "1014": 0.16359257698059082, "1020": 0.08692999184131622, "1023": 0.17759032547473907, "1026": 0.05694137513637543, "1042": 0.3916989266872406, "1048": 0.5640701055526733, "1049": 0.40351006388664246, "1052": 0.25239890813827515, "1060": 0.5756692886352539, "1998": 0.3304552733898163, "2007... | 18084826 | Accurate measurement of fat mass has become increasingly important with the increasing incidence of obesity. We assessed fat and muscle mass of Koreans with the Korea National Health and Nutrition Examination Survey IV (KNHANES IV). We studied 10,456 subjects (aged 20 to 85 yr; 4,476 men, 5,980 women). Fat and muscle m... | Characteristics of Body Fat, Body Fat Percentage and Other Body Composition for Koreans from KNHANES IV |
{"1011": 0.1693800985813141, "1019": 0.2830325961112976, "1055": 1.071556806564331, "2003": 0.18004031479358673, "2029": 0.02412080205976963, "2035": 0.7674643993377686, "2037": 0.030771657824516296, "2041": 0.5816917419433594, "2062": 0.1485546976327896, "2064": 0.026976587250828743, "2072": 1.3279863595962524, "2075"... | 18098290 | Sporophytic self-incompatibility (SSI) is a self-pollen recognition system that enforces outcrossing in plants. Recognition in SSI systems is typically controlled by a complex locus (5-locus) with separate genes that determine pollen and stigma specificity. Experimental studies show that S-alleles can be dominant, rece... | The Evolution of Dominance in Sporophytic Self-Incompatibility Systems. II. Mate Availability and Recombination |
{"1044": 0.018384648486971855, "2007": 0.574020504951477, "2020": 0.08603433519601822, "2026": 0.6197150945663452, "2039": 0.39696553349494934, "2091": 0.29981520771980286, "2106": 0.2493593990802765, "2109": 0.2918238639831543, "2135": 0.09850110858678818, "2179": 0.030771657824516296, "2229": 0.23633737862110138, "22... | 18104691 | AIM This review explores the molecular, neurological, and behavioural outcomes in animal models of uterine artery ligation. We analyse the relevance of this type of model to the pathological and functional phenotypes that are consistent with cerebral palsy and its developmental comorbidities in humans. METHOD A literat... | Neurological outcomes of animal models of uterine artery ligation and relevance to human intrauterine growth restriction: a systematic review |
{"1011": 0.3560888469219208, "1041": 0.0009760859538801014, "1050": 0.23864774405956268, "2000": 0.06795065850019455, "2003": 0.09050461649894714, "2007": 0.08961215615272522, "2011": 0.3269403576850891, "2029": 0.12986256182193756, "2053": 0.2409527748823166, "2063": 0.05970508232712746, "2064": 0.2749055027961731, "2... | 18111172 | Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined. We sought to address this question by analysing cellular NHEJ of ends with systematically mispaired and damaged termini. We show NHEJ is... | The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining |
{"1011": 0.2711893916130066, "1015": 0.02887592278420925, "1017": 0.09495500475168228, "1019": 0.6022219061851501, "1020": 0.055094651877880096, "1041": 0.7969439625740051, "1043": 0.6664261221885681, "1048": 0.2881702482700348, "1996": 0.07341018319129944, "1999": 0.05970508232712746, "2007": 0.39893341064453125, "200... | 18126445 | LL5beta has been identified as a microtubule-anchoring factor that attaches EB1/CLIP-associating protein (CLASP)-bound microtubule plus ends to the cell cortex. In this study, we show that LL5beta and its homologue LL5alpha (LL5s) colocalize with autocrine laminin-5 and its receptors, integrins alpha3beta1 and alpha6be... | Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5α/β |
{"1011": 0.13157635927200317, "1016": 0.2607102394104004, "1997": 0.03360854089260101, "2004": 0.07612881064414978, "2005": 0.16442140936851501, "2007": 0.045809537172317505, "2008": 0.06520967930555344, "2011": 0.11168810725212097, "2015": 0.3070250153541565, "2024": 0.19862671196460724, "2029": 0.18492233753204346, "... | 18144189 | DNA topoisomerases solve the topological problems associated with DNA replication, transcription, recombination, and chromatin remodeling by introducing temporary single- or double-strand breaks in the DNA. In addition, these enzymes fine-tune the steady-state level of DNA supercoiling both to facilitate protein intera... | DNA topoisomerases: structure, function, and mechanism. |
{"1011": 0.07341018319129944, "1053": 0.03925827145576477, "1997": 0.5795059204101562, "2000": 0.2800849378108978, "2005": 0.5284429788589478, "2029": 0.14349138736724854, "2064": 0.37974658608436584, "2078": 0.5336109399795532, "2079": 0.052318159490823746, "2092": 0.08871890604496002, "2109": 0.6950984001159668, "211... | 18153456 | BACKGROUND Good-quality artemisinin drugs are essential for malaria treatment, but increasing prevalence of poor-quality artemisinin drugs in many endemic countries hinders effective management of malaria cases. METHODS To develop a point-of-care assay for rapid identification of counterfeit and substandard artemisinin... | Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings |
{"1006": 0.19381128251552582, "1009": 0.981317400932312, "1011": 0.4531385898590088, "1014": 0.5528968572616577, "1043": 0.46486347913742065, "1044": 0.7239188551902771, "1048": 0.129004567861557, "1052": 0.5021947622299194, "1060": 0.23402166366577148, "1155": 0.35060185194015503, "1997": 0.00875066313892603, "2002": ... | 18174210 | BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb). Individuals homozygous for alpha(+)-thalassaemia have microcytosis and an increased erythrocyte count. Alpha(+)-thalassaemia homozygosity confers co... | Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia |
{"1038": 0.7863243818283081, "1041": 0.41065993905067444, "1047": 0.956112265586853, "1513": 0.00875066313892603, "1999": 0.306306391954422, "2000": 0.1913948506116867, "2005": 0.1751343309879303, "2011": 0.025073638185858727, "2020": 0.1602703034877777, "2028": 0.2539152204990387, "2029": 0.05139094591140747, "2035": ... | 18188022 | We have systematically made a set of precisely defined, single‐gene deletions of all nonessential genes in Escherichia coli K‐12. Open‐reading frame coding regions were replaced with a kanamycin cassette flanked by FLP recognition target sites by using a one‐step method for inactivation of chromosomal genes and primers... | Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection |
{"1015": 0.00875066313892603, "1021": 0.7728893756866455, "1023": 0.06246116757392883, "1039": 0.04767346754670143, "1044": 0.6471850275993347, "1049": 0.5495203733444214, "2002": 0.08513788133859634, "2005": 0.11604541540145874, "2007": 0.083342544734478, "2011": 0.21687394380569458, "2012": 0.06520967930555344, "2013... | 18190552 | BACKGROUND Avian influenza (AI) caused by H7 AI viruses (AIVs) of both low pathogenicity (LP) and high pathogenicity (HP) are notifiable poultry diseases. OBJECTIVES Design and validate two RealTime reverse transcriptase polymerase chain reactions (RRT PCRs) for Eurasian H7 AIV detection and pathotyping. METHODS The H7... | Validated RealTime reverse transcriptase PCR methods for the diagnosis and pathotyping of Eurasian H7 avian influenza viruses |
{"1011": 0.23402166366577148, "1014": 0.12470348179340363, "1017": 0.0058422754518687725, "1020": 0.848413348197937, "1022": 0.5162794589996338, "1023": 0.22392450273036957, "1039": 0.4879087805747986, "1040": 0.35403475165367126, "1045": 0.10555581003427505, "1052": 0.2539152204990387, "1609": 0.20022670924663544, "20... | 18199839 | BACKGROUND Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional... | Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies |
{"1011": 0.09317722171545029, "1041": 0.3325583338737488, "1043": 0.7737906575202942, "1048": 0.2786078155040741, "2003": 0.036437395960092545, "2004": 0.1064341589808464, "2005": 0.13499516248703003, "2008": 0.0752234235405922, "2013": 0.20660123229026794, "2024": 0.2763880789279938, "2029": 0.010684899985790253, "204... | 18207615 | Despite the promise of RNA interference (RNAi) and its potential, e.g. for use in cancer therapy, several technical obstacles must first be overcome. The major hurdle of RNAi-based therapeutics is to deliver nucleic acids across the cell's plasma membrane. This study demonstrates that exosome vesicles derived from huma... | Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes |
{"1011": 0.4831010699272156, "1014": 0.20580662786960602, "1018": 0.09317722171545029, "1052": 0.6744182109832764, "1053": 0.3662964701652527, "1054": 0.10026945173740387, "1999": 0.14518201351165771, "2002": 0.6186635494232178, "2029": 0.13157635927200317, "2033": 0.04113444685935974, "2044": 0.401551216840744, "2050"... | 18218379 | PURPOSE AND EXPERIMENTAL DESIGN Using real-time quantitative methylation-specific PCR (RTQ-MSP), we quantified methylated p16INK4a sequences and determined the fractional concentrations of circulating tumor DNA in plasma, serum, and peripheral blood cells collected preoperatively, intraoperatively, and postoperatively ... | Quantitative analysis of tumor-derived methylated p16INK4a sequences in plasma, serum, and blood cells of hepatocellular carcinoma patients. |
{"1011": 0.33115679025650024, "1015": 0.3923587501049042, "1054": 0.39893341064453125, "1996": 0.055094651877880096, "2000": 0.004870930220931768, "2005": 0.19220098853111267, "2008": 0.10203468054533005, "2011": 0.2317005842924118, "2028": 0.09761575609445572, "2029": 0.17020416259765625, "2058": 0.2881702482700348, "... | 18231257 | The small GTPase Rac1 orchestrates actin-dependent remodeling essential for numerous cellular processes including synapse development. While precise spatiotemporal regulation of Rac1 is necessary for its function, little is known about the mechanisms that enable Rac1 activators (GEFs) and inhibitors (GAPs) to act in co... | Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. |
{"1011": 0.36358460783958435, "1018": 0.5197699069976807, "1039": 0.2852376699447632, "1056": 0.7463917136192322, "1062": 0.040196798741817474, "1160": 0.9139442443847656, "2002": 0.00875066313892603, "2008": 0.06612417846918106, "2011": 0.2786078155040741, "2029": 0.3297532796859741, "2038": 0.025073638185858727, "206... | 18231807 | Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects of CD19 CARs relate to greater susceptibility of hematologic malignanci... | 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors |
{"1014": 0.22392450273036957, "1019": 0.1011524572968483, "1022": 0.058784693479537964, "1043": 0.026025565341114998, "1997": 0.17431432008743286, "2003": 0.045809537172317505, "2008": 0.1905880719423294, "2013": 0.13499516248703003, "2015": 0.18816383183002472, "2026": 1.0037577152252197, "2029": 0.10555581003427505, ... | 18236313 | Measureable rates of genome evolution are well documented in human pathogens but are less well understood in bacterial pathogens in the wild, particularly during and after host switches. Mycoplasma gallisepticum (MG) is a pathogenic bacterium that has evolved predominantly in poultry and recently jumped to wild house f... | Ultrafast Evolution and Loss of CRISPRs Following a Host Shift in a Novel Wildlife Pathogen, Mycoplasma gallisepticum |
{"1009": 0.2223619967699051, "1022": 0.014542185701429844, "1040": 0.004870930220931768, "1056": 1.0087559223175049, "2000": 0.13414156436920166, "2006": 0.19782574474811554, "2007": 0.23556606471538544, "2011": 0.2409527748823166, "2015": 0.9194108247756958, "2029": 0.1619328260421753, "2064": 0.36086538434028625, "20... | 18237384 | Induction of tumor-specific immunity requires that dendritic cells (DCs) efficiently capture and present tumor antigens to result in the expansion and activation of tumor-specific cytotoxic T cells. The transition from antigen capture to T cell stimulation requires a maturation signal; in its absence tolerance, rather ... | Inducing Tumor Immunity through the Selective Engagement of Activating Fcγ Receptors on Dendritic Cells |
{"1013": 0.12556517124176025, "1020": 0.0029254043474793434, "1038": 0.06429435312747955, "1048": 0.3910386264324188, "1056": 0.2409527748823166, "1997": 0.05694137513637543, "1999": 0.14349138736724854, "2022": 0.06886265426874161, "2026": 0.4462870955467224, "2075": 0.5116065740585327, "2090": 0.13157635927200317, "2... | 18256197 | BACKGROUND AND PURPOSE The level of total homocysteine (tHcy) that confers a risk of ischemic stroke is unsettled, and no prospective cohort studies have included sufficient elderly minority subjects. We investigated the association between mild to moderate fasting tHcy level and the incidence of ischemic stroke, myoca... | Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study. |
{"1011": 0.2881702482700348, "1025": 0.0842406153678894, "1035": 0.03360854089260101, "1040": 0.14602625370025635, "1044": 1.1400591135025024, "1049": 0.4617912769317627, "2002": 1.1641268730163574, "2003": 0.33953672647476196, "2005": 0.23402166366577148, "2008": 0.11865071207284927, "2010": 0.49864232540130615, "2013... | 18261004 | The Heparin-Binding Haemagglutinin (HBHA) is a mycobacterial adhesin involved in the dissemination of Mycobacterium tuberculosis from the site of primary infection and a potential candidate for the development of a new vaccine against tuberculosis. Methylation of HBHA is a novel post-translational event that imparts im... | Expression and purification of recombinant methylated HBHA in Mycobacterium smegmatis. |
{"1039": 0.3012613356113434, "1053": 0.11778303235769272, "1997": 0.1734936386346817, "2000": 0.04674193635582924, "2003": 0.23864774405956268, "2004": 0.36900100111961365, "2005": 0.12986256182193756, "2011": 0.0029254043474793434, "2048": 0.46486347913742065, "2054": 0.13414156436920166, "2064": 0.10993985831737518, ... | 18263406 | Alternative lengthening of telomeres (ALT) is one of the two known telomere length maintenance mechanisms that are essential for the unlimited proliferation potential of cancer cells. Existing methods for detecting ALT in tumors require substantial amounts of tumor material and are labor intensive, making it difficult ... | Detection of alternative lengthening of telomeres by telomere quantitative PCR |
{"1011": 0.18654440343379974, "1016": 0.13243216276168823, "1018": 0.175953671336174, "1037": 0.07250232994556427, "1043": 0.7076893448829651, "2011": 0.2317005842924118, "2029": 0.24401791393756866, "2035": 0.29328158497810364, "2041": 0.28890204429626465, "2046": 0.22782009840011597, "2051": 0.3547199070453644, "2063... | 18264714 | All cells perceive and respond to environmental stresses through elaborate stress-sensing networks. Yeast cells sense stress through diverse signaling pathways that converge on the transcription factors Msn2 and Msn4, which respond by initiating rapid, idiosyncratic cycles into and out of the nucleus. To understand the... | Noise and interlocking signaling pathways promote distinct transcription factor dynamics in response to different stresses |
{"1003": 0.12556517124176025, "1018": 0.09317722171545029, "1023": 0.6877616047859192, "1997": 0.16359257698059082, "2000": 0.24248650670051575, "2039": 0.5162794589996338, "2047": 0.22548456490039825, "2050": 0.8550800085067749, "2052": 0.20818853378295898, "2065": 0.09938567131757736, "2073": 0.021256839856505394, "2... | 18268012 | OBJECTIVES To estimate the present value of current and future funding needed for HIV treatment and prevention in 9 sub-Saharan African (SSA) countries that account for 70% of HIV burden in Africa under different scenarios of intervention scale-up. To analyse the gaps between current expenditures and funding obligation... | Long-term financing needs for HIV control in sub-Saharan Africa in 2015-2050: a modelling study. |
{"1009": 0.42544642090797424, "1011": 0.17020416259765625, "1015": 0.2018241584300995, "1022": 0.02792670577764511, "1039": 0.08782484382390976, "1041": 0.39696553349494934, "1044": 0.6202403903007507, "1048": 0.16524957120418549, "1049": 0.47463157773017883, "1051": 0.21765978634357452, "1055": 0.6149744987487793, "10... | 18275697 | The development of improved typhoid vaccines is a high global public health priority. However, their development has been hampered by a lack of information regarding the specific determinants of protective immunity to Salmonella enterica serovar Typhi (S. Typhi) infection in humans. Although antibodies to S. Typhi O, H... | Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica Serovar Typhi strains used as live oral vaccines in humans. |
{"1011": 0.40220460295677185, "1016": 0.3269403576850891, "1017": 0.20501139760017395, "1998": 0.4337083101272583, "2005": 0.05694137513637543, "2007": 0.5461324453353882, "2008": 0.0038986403960734606, "2011": 0.28082266449928284, "2020": 0.0174254160374403, "2029": 0.29036402702331543, "2050": 0.53589928150177, "2064... | 18276599 | Higher-order chromosomal organization for transcription regulation is poorly understood in eukaryotes. Using genome-wide Chromatin Interaction Analysis with Paired-End-Tag sequencing (ChIA-PET), we mapped long-range chromatin interactions associated with RNA polymerase II in human cells and uncovered widespread promote... | Extensive Promoter-Centered Chromatin Interactions Provide a Topological Basis for Transcription Regulation |
{"1011": 0.05417001247406006, "1038": 0.02316705882549286, "1049": 0.22937409579753876, "1056": 0.07341018319129944, "1062": 0.10555581003427505, "2000": 0.07884006202220917, "2005": 0.41840189695358276, "2007": 0.16607704758644104, "2008": 0.06520967930555344, "2011": 0.11081436276435852, "2012": 0.01934296265244484, ... | 18321590 | A method for detecting multidrug-resistant Mycobacterium tuberculosis by using a reduction of resazurin is described. Eighty clinical isolates were evaluated against isoniazid and rifampin; results at 7 days were compared with those of the proportion method. Specificity and sensitivity were excellent. The method is sim... | Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis. |
{"1045": 0.1808556467294693, "1051": 0.3077431619167328, "1052": 0.2990913391113281, "1999": 0.009718249551951885, "2011": 0.176772341132164, "2015": 0.3191637098789215, "2035": 0.0354953333735466, "2037": 0.22157983481884003, "2042": 0.3034266233444214, "2051": 0.18816383183002472, "2057": 0.09672962874174118, "2058":... | 18333304 | MOTIVATION Circadian oscillations have been observed in animals, plants, fungi and cyanobacteria and play a fundamental role in coordinating the homeostasis and behavior of biological systems. Genetically encoded molecular clocks found in nearly every cell, based on negative transcription/translation feedback loops and... | The pervasiveness and plasticity of circadian oscillations: the coupled circadian-oscillators framework. |
{"1011": 0.2749055027961731, "1019": 0.12384103983640671, "1039": 0.058784693479537964, "1042": 0.7124901413917542, "1048": 0.11604541540145874, "1054": 0.029824240133166313, "1056": 0.5290185213088989, "1998": 0.13071982562541962, "2005": 0.23556606471538544, "2012": 0.3127557039260864, "2020": 0.14349138736724854, "2... | 18340282 | BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for evidence of gene-environment interactions, we compared genot... | Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study |
{"1056": 0.08603433519601822, "1081": 0.6218147873878479, "2007": 0.4311734735965729, "2013": 0.1229778528213501, "2025": 0.09584271162748337, "2029": 0.040196798741817474, "2031": 0.07341018319129944, "2043": 0.009718249551951885, "2094": 0.4002431631088257, "2111": 0.16524957120418549, "2116": 0.5139457583427429, "21... | 18344910 | Objectives. To evaluate the predictive value of thrombocytopenia in malaria. Patients and Methods. It was a prospective observational study on all febrile patients with thrombocytopenia presenting to the Medical Unit of Hayat Abad Medical Complex during November 2008 to November 2010. Results. Of the total of 228 patie... | Thrombocytopenia as an Indicator of Malaria in Adult Population |
{"1011": 0.17840765416622162, "1018": 0.010684899985790253, "1021": 0.40220460295677185, "1040": 0.5579402446746826, "1043": 0.9455460906028748, "1045": 0.4752389192581177, "1048": 0.2394166737794876, "1055": 0.6931471824645996, "1999": 0.04207121208310127, "2011": 0.1229778528213501, "2012": 0.3443928062915802, "2015"... | 18346333 | Glutamate receptors mediate the majority of excitatory synaptic transmission in the CNS. The AMPA-subtype has rapid kinetics, with activation, deactivation and desensitization proceeding on the millisecond timescale or faster. Crystallographic, biochemical, and functional studies suggest that GluR2 Cys mutants which fo... | AMPA receptor ligand binding domain mobility revealed by functional cross linking. |
{"1009": 0.5528968572616577, "1011": 0.21293537318706512, "1017": 0.15442965924739838, "1018": 0.20580662786960602, "1039": 0.037378571927547455, "1050": 0.16359257698059082, "1056": 0.8707374930381775, "1059": 0.6000806093215942, "2007": 0.36358460783958435, "2011": 0.39696553349494934, "2012": 0.10906458646059036, "2... | 18348376 | BACKGROUND Multiple mechanisms have been advanced to account for CD4+FOXP3+ regulatory T cell (Treg)-mediated suppression of CD4+ effector T cells (Teffs) but none appear to completely explain suppression. Previous data indicates that Tregs may affect the microenvironment redox state. Given the inherent redox sensitivi... | Ncf1 (p47phox) Is Essential for Direct Regulatory T Cell Mediated Suppression of CD4+ Effector T Cells |
{"1015": 0.19622190296649933, "1018": 0.14686977863311768, "1040": 0.7537717819213867, "1043": 0.5957841277122498, "1044": 0.6086184978485107, "2010": 0.7809720039367676, "2011": 0.2493593990802765, "2012": 0.18411032855510712, "2029": 0.21530038118362427, "2033": 0.0606246218085289, "2076": 0.11256109178066254, "2078"... | 18358026 | Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin. DNMT1 becomes part of a complex(es) containing DNMT3B and members of the polycomb repressive... | Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. |
{"1041": 0.09761575609445572, "1042": 0.48670899868011475, "2000": 0.010684899985790253, "2005": 0.11778303235769272, "2011": 0.20501139760017395, "2013": 0.5347557663917542, "2046": 0.021256839856505394, "2049": 0.0842406153678894, "2064": 0.45499902963638306, "2071": 0.2918238639831543, "2073": 0.026025565341114998, ... | 18361917 | PURPOSE The adult newt can regenerate lens from pigmented epithelial cells (PECs) of the dorsal iris via dedifferentiation. The purpose of this research is to obtain sequence resources for a newt lens regeneration study and to obtain insights of dedifferentiation at the molecular level. METHODS mRNA was purified from i... | Expression profiles during dedifferentiation in newt lens regeneration revealed by expressed sequence tags |
{"1003": 0.07250232994556427, "1011": 0.3127557039260864, "1040": 0.48970574140548706, "1043": 0.37304413318634033, "1044": 0.11081436276435852, "1055": 0.22859740257263184, "2002": 0.11865071207284927, "2004": 0.14686977863311768, "2013": 0.21687394380569458, "2029": 0.029824240133166313, "2043": 0.3601844012737274, "... | 18374364 | A rare set of hematopoietic stem cells (HSC) must undergo a massive expansion to produce mature blood cells. The phenotypic isolation of HSC from mice offers the opportunity to determine directly their proliferation kinetics. We analyzed the proliferation and cell cycle kinetics of long-term self-renewing HSC (LT-HSC) ... | In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. |
{"1011": 0.15693697333335876, "1017": 0.6744182109832764, "1020": 0.9951307773590088, "1042": 0.35060185194015503, "1050": 0.8004589080810547, "1997": 0.19220098853111267, "1998": 0.07159364968538284, "1999": 0.23864774405956268, "2000": 0.0770333781838417, "2003": 0.25694093108177185, "2005": 0.15943801403045654, "200... | 18375089 | Angiogenesis is a necessary step in tumor growth and metastasis. It is well established that the metabolites of omega-6 and omega-3 fatty acids, which must be obtained through the diet and cannot be synthesized de novo in mammals, have differential effects on cellular processes. Omega-6 fatty acid (n−6 FA)-derived meta... | The role of the tissue omega-6/omega-3 fatty acid ratio in regulating tumor angiogenesis |
{"1021": 0.3388410806655884, "1049": 0.08692999184131622, "1996": 0.13071982562541962, "1997": 0.19381128251552582, "2014": 0.13925230503082275, "2034": 0.21765978634357452, "2051": 0.42735910415649414, "2057": 0.11691460013389587, "2064": 0.018384648486971855, "2079": 0.1994270235300064, "2090": 0.5238267183303833, "2... | 18379855 | Humans, like other animals, are exposed to a continuous stream of signals, which are dynamic, multimodal, extended, and time varying in nature. This complex input space must be transduced and sampled by our sensory systems and transmitted to the brain where it can guide the selection of appropriate actions. To simplify... | The Natural Statistics of Audiovisual Speech |
{"1011": 0.1332872211933136, "1017": 0.013579257763922215, "1040": 0.06246116757392883, "1043": 0.950843095779419, "1052": 0.6181373596191406, "1999": 0.6950984001159668, "2005": 0.16276304423809052, "2011": 0.05046287178993225, "2013": 0.4349733293056488, "2015": 0.3916989266872406, "2024": 0.05139094591140747, "2029"... | 18399038 | Glioma tumour-initiating cells (GTICs) can originate upon the transformation of neural progenitor cells (NPCs). Studies on GTICs have focused on primary tumours from which GTICs could be isolated and the use of human embryonic material. Recently, the somatic genomic landscape of human gliomas has been reported. RTK (re... | Establishment of human iPSC-based models for the study and targeting of glioma initiating cells |
{"1015": 0.36290550231933594, "1016": 0.18978065252304077, "1020": 0.1873544454574585, "1039": 0.21687394380569458, "1043": 0.7276995778083801, "1045": 0.7683706283569336, "1047": 0.6892333030700684, "1052": 0.8509185314178467, "1999": 0.06246116757392883, "2011": 0.29109421372413635, "2012": 0.07068414986133575, "2015... | 18414462 | Although the lung is a defining feature of air-breathing animals, the pathway controlling the formation of type I pneumocytes, the cells that mediate gas exchange, is poorly understood. In contrast, the glucocorticoid receptor and its cognate ligand have long been known to promote type II pneumocyte maturation; prenata... | Thyroid Hormone Receptor Repression Linked to Type I Pneumocyte Associated Respiratory Distress Syndrome |
{"1011": 0.25995752215385437, "1039": 0.0354953333735466, "1609": 0.2247048318386078, "2002": 0.7969439625740051, "2004": 0.2667117714881897, "2007": 0.12038381397724152, "2015": 0.3084607720375061, "2029": 0.129004567861557, "2049": 0.007782140281051397, "2052": 0.04767346754670143, "2058": 0.03925827145576477, "2064"... | 18421962 | Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA abundances from individual genes can modulate the activity of miRNAs. Consideration of this hypothesis would benefit from knowing the quantitative relati... | Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. |
{"1018": 0.2034190446138382, "1045": 0.6176109313964844, "1056": 0.28670501708984375, "2000": 0.02316705882549286, "2003": 0.23633737862110138, "2005": 0.22937409579753876, "2006": 0.10467668622732162, "2009": 0.06520967930555344, "2011": 0.14264501631259918, "2019": 0.5936289429664612, "2035": 0.8583967685699463, "204... | 18429416 | Food allergy is a major public health concern in westernized countries, estimated to affect 5 % of children and 3–4 % of adults. Allergen-specific immunotherapy for food allergy is currently being actively evaluated, but is still experimental. The optimal protocol, in terms of the route of administration of the food, t... | Immunological mechanisms for desensitization and tolerance in food allergy |
{"1011": 0.05139094591140747, "1040": 0.1718502640724182, "1052": 0.47463157773017883, "1055": 0.06612417846918106, "1997": 0.18167030811309814, "2007": 0.0770333781838417, "2015": 0.31132611632347107, "2029": 0.043007105588912964, "2033": 0.4512746334075928, "2050": 0.19622190296649933, "2053": 0.15777134895324707, "2... | 18446525 | The motor symptoms of Parkinson’s disease (PD), bradykinesia, muscular rigidity, and tremor depend upon degeneration of the dopaminergic neurons in the substantia nigra pars compacta. Recent neuropathological studies show that the Lewy bodies, the intraneuronal landmark of PD, accumulate in several neuronal cell types ... | Prodromal non-motor symptoms of Parkinson’s disease |
{"1011": 0.38041436672210693, "1013": 0.07612881064414978, "1017": 0.06429435312747955, "1043": 0.5168620347976685, "1047": 1.1456648111343384, "1055": 0.08692999184131622, "1062": 0.2719337046146393, "1997": 0.07612881064414978, "1999": 0.02412080205976963, "2003": 0.17431432008743286, "2004": 0.02412080205976963, "20... | 18447487 | The Sp/Krüppel-like factor (Sp/Klf) family is comprised of around 25 zinc finger transcription factors that recognize CACCC boxes and GC-rich elements. We have investigated basic Krüppel-like factor (Bklf/Klf3) and show that in erythroid tissues its expression is highly dependent on another family member, erythroid Krü... | Erythroid Krüppel-Like Factor Directly Activates the Basic Krüppel-Like Factor Gene in Erythroid Cells � |
{"1011": 0.0019512200960889459, "1019": 0.5393219590187073, "1020": 0.4437839686870575, "1059": 1.0815403461456299, "2011": 0.22859740257263184, "2026": 0.4412745535373688, "2033": 0.1970241367816925, "2039": 0.029824240133166313, "2050": 0.535327672958374, "2058": 0.4624064862728119, "2079": 0.07612881064414978, "2106... | 18450716 | Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance in obese individuals. Cell culture studies and gain-of-function mouse models suggest that canonical Wnt proteins modulate adipose tissue expansion. However, no genetic evidence supports a role for endogenous Wnt proteins in adipose... | Noncanonical Wnt Signaling Promotes Obesity-Induced Adipose Tissue Inflammation and Metabolic Dysfunction Independent of Adipose Tissue Expansion |
{"1005": 0.19541899859905243, "1011": 0.4914994537830353, "1015": 0.38308101892471313, "1017": 0.16276304423809052, "1019": 0.7737906575202942, "1022": 0.5324648022651672, "1054": 0.030771657824516296, "1996": 0.2160874605178833, "1997": 0.18573370575904846, "1999": 0.11691460013389587, "2005": 0.06337817758321762, "20... | 18467982 | The 5'-exonuclease Rat1 degrades pre-rRNA spacer fragments and processes the 5'-ends of the 5.8S and 25S rRNAs. UV crosslinking revealed multiple Rat1-binding sites across the pre-rRNA, consistent with its known functions. The major 5.8S 5'-end is generated by Rat1 digestion of the internal transcribed spacer 1 (ITS1) ... | A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease |
{"1043": 0.17759032547473907, "1062": 1.2905446290969849, "1998": 0.06886265426874161, "2003": 0.22782009840011597, "2005": 0.4914994537830353, "2007": 0.28890204429626465, "2010": 0.5450005531311035, "2011": 0.09317722171545029, "2024": 0.32129061222076416, "2029": 0.006812678650021553, "2033": 0.839173436164856, "206... | 18473550 | Bisphosphonates are widely used agents for the treatment of malignant bone disease. They inhibit osteoclast-mediated bone resorption and can have direct effects on cancer cells. In this study, we investigated whether the anticancer activity of the third-generation bisphosphonate zoledronic acid (ZOL) could be enhanced ... | Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro. |
{"1009": 0.6107416749000549, "1011": 0.24018502235412598, "1016": 0.0029254043474793434, "1022": 0.28450319170951843, "1045": 0.4914994537830353, "1049": 0.31132611632347107, "1056": 0.7601850032806396, "1999": 0.06886265426874161, "2005": 0.29400965571403503, "2007": 0.011650617234408855, "2011": 0.28670501708984375, ... | 18488986 | The expression of melanoma-associated antigens (MAA) being limited to normal melanocytes and melanomas, MAAs are ideal targets for immunotherapy and melanoma vaccines. As MAAs are derived from self, immune responses to these may be limited by thymic tolerance. The extent to which self-tolerance prevents efficient immun... | The Immune Response to Melanoma Is Limited by Thymic Selection of Self-Antigens |
{"1011": 0.4190443754196167, "1016": 0.5707147121429443, "1017": 0.5898461937904358, "1018": 0.13414156436920166, "1038": 0.32270604372024536, "1040": 0.4311734735965729, "1041": 0.7537717819213867, "1047": 0.9470623731613159, "2005": 0.16524957120418549, "2006": 0.025073638185858727, "2011": 0.11343330889940262, "2015... | 18489989 | Embryonic stem (ES) cells homozygous for a Shp-2 mutation (Shp-2(Delta46-110)) demonstrate leukemia inhibitory factor (LIF) hypersensitivity and increased LIF-stimulated phosphorylation of signal transducer and activator of transcription (STAT3). We hypothesized that LIF-responsive genes in Shp-2(Delta46-110) cells wou... | Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. |
{"1006": 0.06429435312747955, "1012": 0.17840765416622162, "1013": 0.36426326632499695, "1021": 0.3588210940361023, "1043": 0.056018441915512085, "1049": 0.4337083101272583, "2001": 0.022212404757738113, "2003": 0.4450363218784332, "2005": 0.15526613593101501, "2015": 0.19541899859905243, "2042": 0.07793712615966797, "... | 18494847 | MicroScope is an integrated platform dedicated to both the methodical updating of microbial genome annotation and to comparative analysis. The resource provides data from completed and ongoing genome projects (automatic and expert annotations), together with data sources from post-genomic experiments (i.e. transcriptom... | MicroScope—an integrated microbial resource for the curation and comparative analysis of genomic and metabolic data |
{"1013": 0.2954642176628113, "1014": 0.319873183965683, "1016": 0.05970508232712746, "1019": 0.09938567131757736, "1020": 0.17020416259765625, "1023": 0.09495500475168228, "1043": 0.09850110858678818, "1044": 0.5057345628738403, "1051": 0.0029254043474793434, "1052": 0.3141832649707794, "1058": 0.37035053968429565, "10... | 18537148 | The purpose of this investigation was to determine whether maximal oxygen consumption (VO2max) differed between two selected groups of black and white children and whether a difference existed to determine whether it was related to hematologic profiles, body composition, and/or physical activity/inactivity level. Forty... | Comparison of Maximal Oxygen Consumption Between Black and White Prepubertal and Pubertal Children |
{"1006": 0.08692999184131622, "1009": 1.0001721382141113, "1011": 0.27564704418182373, "1016": 0.12384103983640671, "1017": 0.17267228662967682, "1018": 0.4580921530723572, "1019": 0.06703783571720123, "1039": 0.2786078155040741, "1052": 0.46914875507354736, "1056": 1.1653456687927246, "1999": 0.03360854089260101, "200... | 18546584 | CD4(+) helper T (Th) cells play a crucial role in the delicate balance between host defense and autoimmune disease. Two important populations of helper T cells are the proinflammatory, interleukin-17 (IL-17)-producing (Th17) cells and the anti-inflammatory forkhead box P3-positive (FoxP3(+)) T regulatory (Treg) cells. ... | Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway. |
{"1014": 0.42799583077430725, "1017": 0.02412080205976963, "1019": 0.11778303235769272, "1022": 0.12470348179340363, "1023": 0.23864774405956268, "1026": 0.1677299439907074, "1038": 0.36900100111961365, "1040": 0.5027855634689331, "1042": 0.8195732831954956, "1044": 0.15526613593101501, "1052": 0.5685047507286072, "199... | 18557974 | High plasma total homocysteine (tHcy) concentration is reported to be a risk factor for vascular diseases. We investigated the extent to which serum folate and plasma tHcy respond to a high intake of natural folate from food. Thirty-seven healthy females volunteered t o participate in a crossover dietary intervention. ... | British Journal of Nutrition (2003), 89, 295–301 q The Authors 2003 DOI: 10.1079/BJN2002776 Plasma homocysteine concentration is decreased by dietary intervention* |
{"1041": 0.012615402229130268, "1042": 0.0354953333735466, "1051": 0.39762192964553833, "1055": 0.3723714053630829, "2000": 0.28670501708984375, "2003": 0.15860503911972046, "2005": 0.06429435312747955, "2029": 0.045809537172317505, "2034": 0.12384103983640671, "2039": 0.03831886500120163, "2058": 0.40220460295677185, ... | 18568804 | Superresolution Optical Fluctuation Imaging (SOFI) as initially demonstrated allows for a resolution enhancement in imaging by a factor of square-root of two. Here, we demonstrate how to increase the resolution of SOFI images by re-weighting the Optical Transfer Function (OTF). Furthermore, we demonstrate how cross-cum... | Achieving increased resolution and more pixels with Superresolution Optical Fluctuation Imaging (SOFI) |
{"1003": 0.02316705882549286, "1018": 0.03925827145576477, "1019": 0.31560876965522766, "1038": 0.037378571927547455, "1054": 0.5092619061470032, "2001": 0.0009760859538801014, "2004": 0.7124901413917542, "2005": 0.32058215141296387, "2022": 0.0354953333735466, "2034": 0.43434104323387146, "2064": 0.07612881064414978, ... | 18574146 | OBJECTIVE To evaluate the performance of reagent test strips in screening pregnant women for asymptomatic bacteriuria at their first visit to an antenatal clinic. DESIGN Prospective case series. SETTING Antenatal clinic of a large inner city maternity hospital. SUBJECTS All women attending for their first antenatal cli... | Evaluation of reagent strips in detecting asymptomatic bacteriuria in early pregnancy: prospective case series. |
{"1011": 0.05046287178993225, "1019": 0.10818854719400406, "1042": 0.5849615335464478, "1052": 0.35334911942481995, "1059": 0.674915611743927, "1996": 0.0009760859538801014, "2003": 0.175953671336174, "2029": 0.14349138736724854, "2031": 0.026976587250828743, "2050": 0.436867892742157, "2057": 0.43434104323387146, "207... | 18575183 | Planar cell polarity (PCP) refers to the polarization of cells within the plane of a cell sheet. A distinctive epithelial PCP in vertebrates is the uniform orientation of stereociliary bundles of the sensory hair cells in the mammalian cochlea. In addition to establishing epithelial PCP, planar polarization is also req... | Wnt5a functions in planar cell polarity regulation in mice. |
{"1011": 0.22157983481884003, "1052": 0.7482418417930603, "1155": 0.052318159490823746, "1998": 0.11517547070980072, "2003": 0.00875066313892603, "2005": 0.016465263441205025, "2007": 0.5162794589996338, "2008": 0.05046287178993225, "2026": 1.382380485534668, "2029": 0.2719337046146393, "2033": 0.36290550231933594, "20... | 18576103 | The alpha-pyrone antibiotic myxopyronin (Myx) inhibits bacterial RNA polymerase (RNAP). Here, through a combination of genetic, biochemical, and structural approaches, we show that Myx interacts with the RNAP "switch region"--the hinge that mediates opening and closing of the RNAP active center cleft--to prevent intera... | The RNA Polymerase “Switch Region” Is a Target for Inhibitors |
{"1054": 0.5838727951049805, "1999": 0.11343330889940262, "2001": 0.06246116757392883, "2005": 0.11778303235769272, "2011": 0.22001366317272186, "2013": 0.29036402702331543, "2019": 0.5033760666847229, "2048": 0.5238267183303833, "2053": 0.1064341589808464, "2063": 0.272677481174469, "2064": 0.1685553640127182, "2071":... | 18592108 | The sampling efficiency of light trap catches relative to human bait catches in estimating biting rates of the mosquito Anopheles gambiae Giles was investigated in two types of community in southern Sierra Leone: (i) where most of the inhabitants slept under treated bed nets; and (ii) where most of the inhabitants slep... | How reliable are light traps in estimating biting rates of adult Anopheles gambiae s.l. (Diptera: Culicidae) in the presence of treated bed nets? |
{"1009": 0.22859740257263184, "1011": 0.38441169261932373, "1017": 0.10731173306703568, "1043": 0.7978238463401794, "1049": 0.06154331564903259, "1056": 0.304147332906723, "1999": 0.02316705882549286, "2000": 0.09406650811433792, "2005": 0.1384023278951645, "2006": 0.841701865196228, "2008": 0.036437395960092545, "2011... | 18600579 | We report the development of a new method to induce glioblastoma multiforme in adult immunocompetent mice by injecting Cre-loxP–controlled lentiviral vectors expressing oncogenes. Cell type- or region-specific expression of activated forms of the oncoproteins Harvey-Ras and AKT in fewer than 60 glial fibrillary acidic ... | Development of a novel mouse glioma model using lentiviral vectors |
{"1008": 0.1677299439907074, "1011": 0.04674193635582924, "1046": 0.17759032547473907, "1058": 0.3241194784641266, "1999": 0.10555581003427505, "2001": 0.06886265426874161, "2011": 0.09317722171545029, "2013": 0.21922965347766876, "2025": 0.2184450328350067, "2029": 0.1693800985813141, "2044": 0.129004567861557, "2094"... | 18617259 | We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died from a non-neurological disorder 5 years after receiving a blood transfusion from a donor who subsequently developed vCJD. Protease-resistant prion protein (PrP(res)) was detected by western blot, paraffin-embedded tissue blo... | Research Letters |
{"1015": 0.24554696679115295, "1042": 0.9710156321525574, "1056": 0.004870930220931768, "2011": 0.18004031479358673, "2012": 0.1905880719423294, "2025": 0.14518201351165771, "2061": 0.22937409579753876, "2064": 0.13414156436920166, "2065": 0.1970241367816925, "2072": 0.8861536383628845, "2075": 0.5370414853096008, "208... | 18639989 | Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural replication impediments present throughout the genome. The fork protection complex (FPC) is thoug... | Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres |
{"1011": 0.1930064558982849, "1014": 0.5336109399795532, "1997": 0.16690383851528168, "2005": 0.016465263441205025, "2011": 0.14349138736724854, "2015": 0.306306391954422, "2020": 0.10379679501056671, "2022": 0.0752234235405922, "2024": 0.1710275560617447, "2029": 0.1384023278951645, "2034": 0.2531573474407196, "2038":... | 18654430 | BACKGROUND MicroRNAs (miRNAs) are produced by the sequential processing of a long hairpin RNA transcript by Drosha and Dicer, an RNase III enzymes, and form transitory small RNA duplexes. One strand of the duplex, which incorporates into RNA-induced silencing complex (RISC) and silences the gene expression is called gu... | Prediction of guide strand of microRNAs from its sequence and secondary structure |
{"1011": 0.1064341589808464, "1038": 0.21293537318706512, "1039": 0.44753631949424744, "1040": 0.3409265875816345, "1997": 0.1710275560617447, "2003": 0.2674594223499298, "2008": 0.10291612148284912, "2015": 0.1905880719423294, "2029": 0.12384103983640671, "2030": 0.3949938118457794, "2047": 0.08782484382390976, "2075"... | 18662787 | Cornelia de Lange syndrome (CdLS) is a multiple malformation disorder characterized by dysmorphic facial features, mental retardation, growth delay and limb reduction defects. We indentified and characterized a new gene, NIPBL, that is mutated in individuals with CdLS and determined its structure and the structures of ... | NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome |
{"1011": 0.29400965571403503, "1039": 0.567951500415802, "1042": 0.53589928150177, "1048": 0.26296505331993103, "1049": 0.20818853378295898, "1050": 0.06612417846918106, "2003": 0.3601844012737274, "2019": 0.5290185213088989, "2024": 0.018384648486971855, "2029": 0.36290550231933594, "2038": 0.03266380727291107, "2072"... | 18676539 | FANCM is a component of the Fanconi anemia (FA) core complex and one FA patient (EUFA867) with biallelic mutations in FANCM has been described. Strikingly, we found that EUFA867 also carries biallelic mutations in FANCA. After correcting the FANCA defect in EUFA867 lymphoblasts, a "clean" FA-M cell line was generated. ... | Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M. |
{"1043": 0.8366385698318481, "1044": 0.09050461649894714, "1058": 0.014542185701429844, "1996": 0.08782484382390976, "1999": 0.175953671336174, "2005": 0.19220098853111267, "2008": 0.03831886500120163, "2011": 0.14349138736724854, "2013": 0.16524957120418549, "2029": 0.2786078155040741, "2058": 0.4132472574710846, "207... | 18678095 | Fast axonal transport (FAT) requires consistent energy over long distances to fuel the molecular motors that transport vesicles. We demonstrate that glycolysis provides ATP for the FAT of vesicles. Although inhibiting ATP production from mitochondria did not affect vesicles motility, pharmacological or genetic inhibiti... | Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport |
{"1041": 0.8022117614746094, "1047": 0.619189441204071, "2003": 0.18654440343379974, "2005": 0.4093637466430664, "2007": 0.2145126610994339, "2010": 0.5957841277122498, "2024": 0.1889725625514984, "2029": 0.1358480453491211, "2044": 0.14095009863376617, "2046": 0.1970241367816925, "2051": 0.03266380727291107, "2086": 0... | 18682109 | Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor (EGFR) mutations. However, relapse typically occurs after an average of 1 year of continuous treatment. A fundamental histological transformation from NSCLC to small-cell lung cancer (SCLC)... | RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer |
{"1009": 0.5844172835350037, "1011": 0.11517547070980072, "2003": 0.21135559678077698, "2004": 0.07159364968538284, "2019": 0.48008447885513306, "2029": 0.11168810725212097, "2043": 0.0019512200960889459, "2044": 0.5033760666847229, "2051": 0.020300358533859253, "2071": 0.12642613053321838, "2075": 0.41195443272590637,... | 18691097 | Bone damage removal and callus formation in response to fatigue loading are essential to prevent fractures. Periostin (Postn) is a matricellular protein that mediates adaptive response of cortical bone to loading. Whether and how periostin influences damage and the injury response to fatigue remains unknown. We investi... | Periostin Deficiency Increases Bone Damage and Impairs Injury Response to Fatigue Loading in Adult Mice |
{"1011": 0.04674193635582924, "1015": 0.613389253616333, "1016": 0.025073638185858727, "1044": 1.0382318496704102, "1051": 0.175953671336174, "1062": 0.23633737862110138, "1999": 0.02792670577764511, "2002": 0.3560888469219208, "2005": 0.18492233753204346, "2008": 0.19622190296649933, "2010": 1.0748957395553589, "2011"... | 18694784 | The yeast histone variant H2AZ (Htz1) is implicated in transcription activation, prevention of the ectopic spread of heterochromatin, and genome integrity. Our genome-wide localization analysis revealed that Htz1 is widely, but nonrandomly, distributed throughout the genome in an SWR1-dependent manner. We found that Ht... | Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling. |
{"1011": 0.09584271162748337, "1996": 0.026976587250828743, "1997": 0.10731173306703568, "2001": 0.07068414986133575, "2005": 0.07068414986133575, "2029": 0.26446542143821716, "2049": 0.030771657824516296, "2060": 0.23864774405956268, "2063": 0.09672962874174118, "2075": 0.3127557039260864, "2093": 0.06886265426874161,... | 18695970 | The genomic organisation of the gene encoding Leishmania (Leishmania) amazonensis arginase as well as its flanking regions were characterised. The size of the transcribed RNA was determined, allowing us to map the genomic sites signalling for RNA trans-splicing and putative polyadenylation regions. The general organisa... | Genomic organisation and transcription characterisation of the gene encoding Leishmania (Leishmania) amazonensis arginase and its protein structure prediction. |
{"1014": 0.18248429894447327, "1019": 0.1718502640724182, "1022": 0.04394211992621422, "1023": 0.0038986403960734606, "1040": 0.5197699069976807, "1041": 0.012615402229130268, "1044": 0.24171993136405945, "1051": 0.06703783571720123, "2002": 0.034552380442619324, "2007": 0.06337817758321762, "2012": 0.4764525294303894,... | 18734652 | Classifying endometrial hyperplasia (EH) according to the severity of glandular crowding (simple hyperplasia (SH) vs complex hyperplasia (CH)) and nuclear atypia (simple atypical hyperplasia (SAH) vs complex atypical hyperplasia (CAH)) should predict subsequent endometrial carcinoma risk, but data on progression are la... | Endometrial carcinoma risk among women diagnosed with endometrial hyperplasia: the 34-year experience in a large health plan |
{"1011": 0.27786844968795776, "1017": 0.6286086440086365, "1019": 0.8004589080810547, "1052": 0.3662964701652527, "1060": 0.0019512200960889459, "1998": 0.0770333781838417, "2005": 0.11430477350950241, "2010": 0.22548456490039825, "2025": 0.36358460783958435, "2026": 1.2494091987609863, "2029": 0.32764431834220886, "20... | 18747744 | We analyzed Pax-3 (splotch), Myf-5 (targeted with nlacZ), and splotch/Myf-5 homozygous mutant mice to investigate the roles that these genes play in programming skeletal myogenesis. In splotch and Myf-5 homozygous embryos, myogenic progenitor cell perturbations and early muscle defects are distinct. Remarkably, splotch... | Redefining the Genetic Hierarchies Controlling Skeletal Myogenesis: Pax-3 and Myf-5 Act Upstream of MyoD |
{"1014": 0.3956514894962311, "1020": 0.23092569410800934, "1041": 0.40806588530540466, "1059": 0.3784096837043762, "2001": 0.04207121208310127, "2012": 0.07431721687316895, "2060": 0.18004031479358673, "2076": 0.03831886500120163, "2109": 0.0038986403960734606, "2139": 0.7629209756851196, "2282": 0.18411032855510712, "... | 18750453 | Background The degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy. To assist management of severely ill children, and to test the hypothesis that volume changes in fluid compartments reflect disease severity, we measured body compartment ... | Assessment of Volume Depletion in Children with Malaria |
{"1011": 0.27712854743003845, "1017": 0.2394166737794876, "1018": 0.304147332906723, "1020": 0.24859806895256042, "1022": 0.4980490207672119, "1039": 0.12814582884311676, "1049": 0.20022670924663544, "1053": 0.8383291959762573, "1056": 0.8238670229911804, "2006": 0.1946154683828354, "2007": 0.2659635543823242, "2029": ... | 18758057 | Direct molecular imaging of nano-spatial relationship between T cell receptor (TCR)/CD3 and CD4 or CD8 co-receptor before and after activation of a primary T cell has not been reported. We have recently innovated application of near-field scanning optical microscopy (NSOM) and immune-labeling quantum dots (QD) to image... | NSOM/QD-Based Direct Visualization of CD3-Induced and CD28-Enhanced Nanospatial Coclustering of TCR and Coreceptor in Nanodomains in T Cell Activation |
{"1011": 0.16524957120418549, "1015": 0.3560888469219208, "1023": 0.5433003902435303, "1038": 0.07159364968538284, "1042": 0.5478278398513794, "1052": 0.8559102416038513, "1060": 0.2409527748823166, "1999": 0.004870930220931768, "2007": 0.5191890001296997, "2008": 0.0058422754518687725, "2015": 0.5092619061470032, "202... | 18806488 | Hoxa9, Meis1 and Pbx1 encode homeodomaincontaining proteins implicated in leukemic transformation in both mice and humans. Hoxa9, Meis1 and Pbx1 proteins have been shown to physically interact with each other, as Hoxa9 cooperatively binds consensus DNA sequences with Meis1 and with Pbx1, while Meis1 and Pbx1 form heter... | Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. |
{"1015": 0.4794800877571106, "1017": 0.18248429894447327, "1041": 0.16524957120418549, "1043": 0.8057082891464233, "1044": 0.4794800877571106, "1052": 0.10818854719400406, "1056": 0.4950772523880005, "1061": 0.861702561378479, "1999": 0.03831886500120163, "2006": 0.7755908370018005, "2008": 0.12814582884311676, "2011":... | 18810195 | How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic biosynthesis by controlling intracellular levels of its substrate 3-phosphoglycerate and product 2-phosphoglycer... | Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation |
{"1014": 0.3170322775840759, "1015": 0.08244366943836212, "1017": 0.1212492436170578, "1018": 0.401551216840744, "1040": 0.11951763927936554, "1052": 0.2800849378108978, "1998": 0.05417001247406006, "2012": 0.09228714555501938, "2013": 0.22079704701900482, "2020": 0.014542185701429844, "2025": 0.09317722171545029, "203... | 18816720 | BACKGROUND Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and environment. An improved understanding of variation in transmission patterns is fun... | Spatial and Temporal Clustering of Dengue Virus Transmission in Thai Villages |
{"1009": 0.5651806592941284, "1011": 0.34577593207359314, "1013": 0.036437395960092545, "1022": 0.6989894509315491, "1039": 0.2447827309370041, "1056": 1.1834511756896973, "1157": 0.2034190446138382, "1996": 0.052318159490823746, "1998": 0.29473719000816345, "2007": 0.3910386264324188, "2011": 0.06520967930555344, "202... | 18834078 | Immunization results in the differentiation of CD8+ T cells, such that they acquire effector abilities and convert into a memory pool. Priming of T cells takes place via an immunological synapse formed with an antigen-presenting cell (APC). By disrupting synaptic stability at different times, we found that the differen... | Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells |
{"1017": 0.32764431834220886, "1044": 0.4879087805747986, "1046": 0.7629209756851196, "1048": 0.46363574266433716, "1052": 0.13157635927200317, "1999": 0.02412080205976963, "2008": 0.12814582884311676, "2010": 1.013020396232605, "2011": 0.0029254043474793434, "2029": 0.22937409579753876, "2046": 0.1384023278951645, "20... | 18841257 | Epigenetic chromatin marks restrict the ability of differentiated cells to change gene expression programs in response to environmental cues and to transdifferentiate. Polycomb group (PcG) proteins mediate gene silencing and repress transdifferentiation in a manner dependent on histone H3 lysine 27 trimethylation (H3K2... | The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene Silencing |
{"1011": 0.07431721687316895, "1017": 0.0354953333735466, "1018": 0.029824240133166313, "1020": 0.07250232994556427, "1021": 0.11691460013389587, "1039": 0.5601736903190613, "1041": 1.0264055728912354, "1043": 0.053244512528181076, "2003": 0.08244366943836212, "2004": 0.06612417846918106, "2005": 0.0019512200960889459,... | 18852643 | In humans, apolipoprotein E (apoE) is a polymorphic multifunctional protein.1 It is coded by three alleles (e2, e3, e4) of a modulator gene (level, variability, and susceptibility gene) at the apoE locus on chromosome 19, determining six apoE genotypes and plasma phenotypes. Its pleiotropic effects are exerted on plasm... | Apolipoprotein E and atherosclerosis: beyond lipid effect. |
{"1041": 0.1212492436170578, "1049": 0.48068851232528687, "1060": 1.1076855659484863, "2003": 0.053244512528181076, "2007": 0.2741633653640747, "2011": 0.08961215615272522, "2015": 0.12642613053321838, "2020": 0.0752234235405922, "2026": 0.9363996982574463, "2034": 0.15693697333335876, "2037": 0.5151132941246033, "2038... | 18855191 | Social organisms that cooperate with some members of their own species, such as close relatives, may fail to cooperate with other genotypes of the same species. Such noncooperation may take the form of outright antagonism or social exploitation. Myxococcus xanthus is a highly social prokaryote that cooperatively develo... | Exploitative and Hierarchical Antagonism in a Cooperative Bacterium |
{"2003": 0.06520967930555344, "2044": 0.5450005531311035, "2063": 0.37102460861206055, "2064": 0.10203468054533005, "2077": 0.2145126610994339, "2089": 0.04394211992621422, "2090": 0.08961215615272522, "2111": 0.0029254043474793434, "2116": 0.11430477350950241, "2139": 0.2689530849456787, "2204": 0.036437395960092545, ... | 18872233 | IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese individuals. Mental health conditions may be common among patients seeking bariatric surgery; however, the prevalence of these conditions and whether they are associated with postoperative outcom... | Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis. |
{"1009": 0.06795065850019455, "1011": 0.3956514894962311, "1015": 0.469759464263916, "1040": 0.28963330388069153, "1042": 0.09761575609445572, "1048": 0.4437839686870575, "1056": 0.8780695199966431, "1059": 0.8366385698318481, "1996": 0.06246116757392883, "1999": 0.04207121208310127, "2004": 0.18492233753204346, "2006"... | 18882947 | The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks in T-cell developme... | The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell–Specific Tumor Suppressor for Development of Lymphomas |
{"1011": 0.16442140936851501, "1018": 0.5133614540100098, "1055": 0.7537717819213867, "1996": 0.022212404757738113, "1997": 0.040196798741817474, "1998": 0.08961215615272522, "1999": 0.04953393340110779, "2005": 0.15275461971759796, "2007": 0.018384648486971855, "2008": 0.07612881064414978, "2011": 0.3519764244556427, ... | 18895793 | The relationship between chromatin structure and gene expression is a subject of intense study. The universal transcriptional activator Gal4 removes promoter nucleosomes as it triggers transcription, but how it does so has remained obscure. The reverse process, repression of transcription, has often been correlated wit... | Activator Control of Nucleosome Occupancy in Activation and Repression of Transcription |
{"1011": 0.12986256182193756, "1013": 0.14518201351165771, "1016": 0.0009760859538801014, "1018": 0.2622140049934387, "1019": 0.23247487843036652, "1038": 0.43244171142578125, "1052": 0.41001203656196594, "1997": 0.06886265426874161, "2002": 0.030771657824516296, "2004": 0.6155022978782654, "2005": 0.05139094591140747,... | 18909530 | Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics. Here, mass spectrometry-calibrated intracellular flow cytometry of human hematopoiesis reveals MIIB to be a major... | Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. |
{"1011": 0.2749055027961731, "1020": 0.22782009840011597, "1043": 0.2501201331615448, "1048": 0.37907835841178894, "1049": 0.7610978484153748, "1999": 0.22626367211341858, "2004": 0.09938567131757736, "2006": 0.8374842405319214, "2011": 0.272677481174469, "2012": 0.2667117714881897, "2013": 0.2394166737794876, "2014": ... | 18914652 | Notwithstanding the well-characterised roles of a number of oncogenes in neoplastic transformation, microRNAs (miRNAs) are increasingly implicated in several human cancers. Discovery of miRNAs in several oncogenic herpesviruses such as KSHV has further highlighted the potential of virus-encoded miRNAs to contribute to ... | Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas |
{"1011": 0.2976420819759369, "1048": 0.9194108247756958, "1050": 0.19220098853111267, "1996": 0.04394211992621422, "1999": 0.08603433519601822, "2005": 0.04487626627087593, "2011": 0.2539152204990387, "2015": 0.43623676896095276, "2024": 0.1913948506116867, "2029": 0.14518201351165771, "2050": 0.3177432417869568, "2073... | 18924534 | The mammalian genome harbors thousands of long noncoding RNA (lncRNA) genes. Recent studies have indicated the involvement of several of these lncRNAs in the regulation of gene expression. lncRNAs play crucial roles in various biological processes ranging from epigenetic gene regulation, transcriptional control, to pos... | Functional insights into the role of nuclear-retained long noncoding RNAs in gene expression control in mammalian cells |
{"1009": 0.371698260307312, "1011": 0.36358460783958435, "1015": 0.12814582884311676, "1022": 0.1602703034877777, "1038": 0.5718178153038025, "1041": 0.7898768186569214, "1045": 0.66441810131073, "1048": 0.7182208299636841, "1049": 0.8161250352859497, "1056": 0.7995813488960266, "2002": 0.17431432008743286, "2006": 0.2... | 18938992 | Virally infected cells degrade intracellular viral proteins proteolytically and present the resulting peptides in association with major histocompatibility complex (MHC) class I molecules to CD8+ cytotoxic T lymphocytes (CTLs). These cells are normally prone to CTL-mediated elimination. However, several viruses have ev... | Downregulation of TAP1 in B lymphocytes by cellular and Epstein-Barr virus-encoded interleukin-10. |
{"1011": 0.09850110858678818, "1015": 0.2800849378108978, "1039": 0.6553317308425903, "1041": 0.1685553640127182, "1045": 0.5162794589996338, "1051": 0.7782850861549377, "1056": 0.8383291959762573, "1156": 0.6674286723136902, "1998": 0.1677299439907074, "2003": 0.15693697333335876, "2015": 0.0913962796330452, "2034": 0... | 18949516 | Reproductive cessation is perhaps the earliest aging phenotype that humans experience. Similarly, reproduction of Caenorhabditis elegans ceases in mid-adulthood. Although somatic aging has been studied in both worms and humans, mechanisms regulating reproductive aging are not yet understood. Here, we show that TGF-β Sm... | TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance |
{"1011": 0.4444103240966797, "1041": 0.4374985992908478, "1056": 0.2409527748823166, "2003": 0.1970241367816925, "2008": 0.02412080205976963, "2013": 0.10818854719400406, "2029": 0.10379679501056671, "2033": 0.8748174905776978, "2043": 0.15023678541183472, "2066": 0.7105726003646851, "2076": 0.4337083101272583, "2079":... | 18953920 | The epithelial-mesenchymal transition (EMT) is a key developmental program that is often activated during cancer invasion and metastasis. We here report that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell... | The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells |
{"1011": 0.07612881064414978, "1017": 0.08871890604496002, "1039": 0.36900100111961365, "1050": 0.9194108247756958, "1082": 0.2607102394104004, "1164": 0.7473171949386597, "2005": 0.0317181795835495, "2011": 0.3423145115375519, "2015": 0.5767669677734375, "2029": 0.10731173306703568, "2071": 0.10818854719400406, "2079"... | 18956141 | Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired antimicrobial factor expr... | NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions |
{"1009": 0.7463917136192322, "1011": 0.176772341132164, "1013": 0.23864774405956268, "1017": 0.151916041970253, "1039": 0.02316705882549286, "1049": 0.3283478021621704, "1996": 0.12814582884311676, "2005": 0.11691460013389587, "2006": 0.8941729068756104, "2010": 0.18492233753204346, "2011": 0.3883931338787079, "2026": ... | 18987782 | The Myc oncogene regulates the expression of several components of the protein synthetic machinery, including ribosomal proteins, initiation factors of translation, RNA polymerase III and ribosomal DNA. Whether and how increasing the cellular protein synthesis capacity affects the multistep process leading to cancer re... | Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency |
{"1014": 0.09672962874174118, "1015": 0.0797421783208847, "1016": 0.42926809191703796, "1017": 0.5104349255561829, "1018": 0.5827828645706177, "1041": 0.15777134895324707, "1043": 0.2622140049934387, "1052": 0.14518201351165771, "2001": 0.037378571927547455, "2004": 0.10291612148284912, "2007": 0.0842406153678894, "202... | 18988265 | BACKGROUND Although we know that exacerbations are key events in chronic obstructive pulmonary disease (COPD), our understanding of their frequency, determinants, and effects is incomplete. In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independ... | Susceptibility to exacerbation in chronic obstructive pulmonary disease. |
{"1011": 0.1485546976327896, "1014": 0.37102460861206055, "1022": 0.10731173306703568, "1026": 0.07431721687316895, "1038": 0.2576959431171417, "1044": 0.06612417846918106, "1052": 0.4873090982437134, "1054": 0.8649974465370178, "1059": 0.2607102394104004, "1061": 0.1401015669107437, "1081": 0.8281423449516296, "2029":... | 18997216 | Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting. We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregnant women relative to nonpregnant matched controls. Integrate... | Sympathetic baroreflex gain in normotensive pregnant women. |
{"1011": 0.3269403576850891, "1039": 0.6165571808815002, "1044": 0.1751343309879303, "1047": 0.7239188551902771, "1049": 0.25088030099868774, "1051": 0.5466978549957275, "1055": 0.5180262327194214, "1997": 0.05139094591140747, "2005": 0.043007105588912964, "2006": 0.2852376699447632, "2008": 0.14433705806732178, "2011"... | 18998807 | The ectopic expression of transcription factors can reprogram cell fate, yet it is unknown how the initial binding of factors to the genome relates functionally to the binding seen in the minority of cells that become reprogrammed. We report a map of Oct4, Sox2, Klf4, and c-Myc (O, S, K, and M) on the human genome duri... | Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome |
{"1015": 0.07793712615966797, "1041": 0.3241194784641266, "1043": 0.3443928062915802, "1045": 0.42225050926208496, "1052": 0.5979346632957458, "1055": 0.056018441915512085, "2006": 0.2018241584300995, "2007": 0.04207121208310127, "2008": 0.06977381557226181, "2029": 0.3982778787612915, "2039": 0.1734936386346817, "2043... | 19004126 | Arterial smooth muscle cells (SMCs) are arrested in the G1 phase of the cell cycle on polymerized type I collagen fibrils, while monomer collagen supports SMC proliferation. Cyclin E-associated kinase and cyclin-dependent kinase 2 (cdk2) phosphorylation are inhibited on polymerized collagen, and levels of the cdk2 inhi... | Fibrillar Collagen Inhibits Arterial Smooth Muscle Proliferation through Regulation of Cdk2 Inhibitors |
{"1009": 0.7258110046386719, "1011": 0.053244512528181076, "1016": 0.5092619061470032, "1018": 0.43623676896095276, "1039": 0.23324857652187347, "1056": 0.9827804565429688, "1155": 0.29400965571403503, "1157": 0.14518201351165771, "1997": 0.016465263441205025, "2011": 0.32905077934265137, "2029": 0.19220098853111267, "... | 19005293 | Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immune system can also affect the character and magnitude of innate inflammatory responses. We found that the response of memory, but not naive, CD4+ T cells enhanc... | Memory CD4+ T cells induce innate responses independently of pathogen |
{"1011": 0.39893341064453125, "1017": 0.8383291959762573, "1049": 0.052318159490823746, "1051": 0.5751199722290039, "1999": 0.00875066313892603, "2005": 0.21372433006763458, "2029": 0.25088030099868774, "2039": 0.5805994272232056, "2093": 0.40611594915390015, "2109": 0.04487626627087593, "2121": 0.12470348179340363, "2... | 19047331 | 3q26.2 amplification in high-grade serous ovarian cancer leads to increased expression of mature microRNA miR551b-3p, which is associated with poor clinical outcome. Importantly, miR551b-3p contributes to resistance to apoptosis and increased survival and proliferation of cancer cells in vitro and in vivo. miR551b-3p u... | Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer. |
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