spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1017": 0.05970508232712746, "1040": 0.24859806895256042, "1054": 0.11517547070980072, "1055": 0.16359257698059082, "1166": 0.14602625370025635, "2003": 0.2470736801624298, "2005": 0.09938567131757736, "2012": 0.026976587250828743, "2015": 1.1300151348114014, "2071": 0.19541899859905243, "2073": 0.10555581003427505, "... | 38037690 | Abstract. Stimulated Raman scattering (SRS) microscopy is used to generate structural and chemical three-dimensional images of native skin. We employed SRS microscopy to investigate the microanatomical features of skin and penetration of topically applied materials. Image depth stacks are collected at distinct waveleng... | Three-dimensional chemical imaging of skin using stimulated Raman scattering microscopy |
{"1042": 0.2969166338443756, "2001": 0.27342069149017334, "2004": 0.4818955361843109, "2007": 0.40806588530540466, "2012": 0.030771657824516296, "2013": 0.23710809648036957, "2018": 0.23402166366577148, "2020": 0.23402166366577148, "2031": 0.1358480453491211, "2042": 0.07250232994556427, "2043": 0.2667117714881897, "20... | 38040186 | Between 1961 and 1990, 52 patients with biopsy-proven familial amyloidosis born in North America were examined at the Mayo Clinic. At the time of diagnosis of familial amyloidosis, 83% of these patients had peripheral neuropathy, 33% had autonomic neuropathy, and 27% had cardiomyopathy. Renal disease was noted in fewer... | Familial amyloidosis: a study of 52 North American-born patients examined during a 30-year period. |
{"1013": 0.05046287178993225, "1018": 0.33953672647476196, "1020": 0.6389714479446411, "1048": 0.5393219590187073, "1996": 0.23092569410800934, "1999": 0.10203468054533005, "2000": 0.11691460013389587, "2004": 0.0009760859538801014, "2005": 0.1221139207482338, "2012": 0.18248429894447327, "2026": 0.16524957120418549, "... | 38043606 | Once across the barrier of the epithelium, macrophages constitute the primary defense against microbial invasion. For most microbes, the acidic, hydrolytically competent environment of the phagolysosome is sufficient to kill them. Despite our understanding of the trafficking events that regulate phagosome maturation, o... | Mycobacterium tuberculosis and the environment within the phagosome. |
{"1011": 0.0317181795835495, "1014": 0.4374985992908478, "1044": 0.39893341064453125, "1054": 0.6588751673698425, "1059": 0.5729197263717651, "1999": 0.7352184057235718, "2000": 0.014542185701429844, "2003": 0.04207121208310127, "2005": 0.151916041970253, "2007": 0.09317722171545029, "2008": 0.006812678650021553, "2011... | 38076716 | We have developed a new generation of genome-wide DNA methylation BeadChip which allows high-throughput methylation profiling of the human genome. The new high density BeadChip can assay over 480K CpG sites and analyze twelve samples in parallel. The innovative content includes coverage of 99% of RefSeq genes with mult... | High density DNA methylation array with single CpG site resolution. |
{"1011": 0.10467668622732162, "1016": 0.15023678541183472, "1996": 0.45994341373443604, "1997": 0.09495500475168228, "1999": 0.0019512200960889459, "2007": 0.1401015669107437, "2008": 0.01934296265244484, "2015": 0.5734702348709106, "2029": 0.2741633653640747, "2031": 0.18816383183002472, "2038": 0.0913962796330452, "2... | 38127792 | In mitosis the cell assembles the bipolar spindle, a microtubule (MT)-based apparatus that segregates the duplicated chromosomes into two daughter cells. Most animal cells enter mitosis with duplicated centrosomes that provide an active source of dynamic MTs. However, it is now established that spindle assembly relies ... | Acentrosomal Microtubule Assembly in Mitosis: The Where, When, and How. |
{"1023": 0.34922540187835693, "1043": 0.5506471395492554, "1049": 0.14686977863311768, "1052": 0.36697331070899963, "1055": 0.42544642090797424, "2003": 0.11604541540145874, "2012": 0.3982778787612915, "2015": 0.0752234235405922, "2029": 0.029824240133166313, "2054": 0.2247048318386078, "2064": 0.011650617234408855, "2... | 38131471 | DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular responses that enable the cell either to eliminate or cope with the damage or to activate a programmed cell death process, presumably to eliminate cell... | Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. |
{"1009": 0.5483922958374023, "1011": 0.2800849378108978, "1013": 0.04860413447022438, "1016": 0.5668440461158752, "1018": 0.21922965347766876, "1019": 0.9783848524093628, "1039": 0.2493593990802765, "1040": 0.10993985831737518, "1044": 0.7276995778083801, "1047": 0.1401015669107437, "1051": 0.28743788599967957, "1054":... | 38143689 | Serotonin 5-HT2C receptors (5-HT(2C)Rs) are almost exclusively expressed in the CNS, and implicated in disorders such as obesity, depression, and schizophrenia. The present study investigated the mechanisms governing the coupling of the 5-HT(2C)R to the extracellular signal-regulated kinases (ERKs) 1/2, using a Chinese... | Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2. |
{"1037": 0.0058422754518687725, "1049": 0.3750596046447754, "1056": 0.34715715050697327, "2000": 0.0913962796330452, "2001": 0.0058422754518687725, "2003": 0.1485546976327896, "2033": 0.1477125883102417, "2042": 0.026025565341114998, "2043": 0.20660123229026794, "2064": 0.030771657824516296, "2079": 0.22001366317272186... | 38180456 | Short-term medical service trips (MSTs) aim to address unmet health care needs of low- and middle-income countries. The lack of critically reviewed empirical evidence of activities and outcomes is a concern. Developing evidence-based recommendations for health care delivery requires systematic research review. I focuse... | Short-term medical service trips: a systematic review of the evidence. |
{"1004": 0.31560876965522766, "1011": 0.5925496220588684, "1016": 0.3464667797088623, "1038": 1.0546929836273193, "1998": 0.26820653676986694, "2001": 0.1212492436170578, "2006": 0.08871890604496002, "2020": 0.10906458646059036, "2029": 0.19782574474811554, "2041": 0.30989447236061096, "2043": 0.21214580535888672, "204... | 38211681 | The amended (revised) Beck Depression Inventory (BDI-IA; Beck & Steer, 1993b) and the Beck Depression Inventory-II (BDI-II; Beck, Steer, & Brown, 1996) were self-administered to 140 psychiatric outpatients with various psychiatric disorders. The coefficient alphas of the BDI-IA and the BDI-II were, respectively, .89 an... | Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. |
{"1011": 0.10555581003427505, "1014": 0.6170841455459595, "1018": 0.08782484382390976, "1040": 0.12814582884311676, "1046": 0.319873183965683, "1050": 0.28963330388069153, "1052": 0.47766464948654175, "1057": 0.43244171142578125, "1060": 0.8298473954200745, "2000": 0.18492233753204346, "2001": 0.07341018319129944, "200... | 38243984 | PURPOSE The goal of this study was to evaluate prospectively the engraftment rate, factors influencing engraftment, and predictability of clinical outcome of low-passage xenografts from patients with resectable pancreatic ductal adenocarcinoma (PDA) and to establish a bank of PDA xenografts. EXPERIMENTAL DESIGN Patient... | Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer. |
{"1011": 0.2184450328350067, "1022": 0.5629584193229675, "1023": 0.5290185213088989, "1043": 0.3339579105377197, "1060": 0.3297532796859741, "1998": 0.23556606471538544, "1999": 0.03360854089260101, "2005": 0.32199856638908386, "2007": 0.3910386264324188, "2008": 0.09228714555501938, "2011": 0.2822965085506439, "2015":... | 38252314 | The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication elongation and prereplication complex (pre-RC) formation, respectively. We found that MCM8 and MCM9 physically associate with each other and that MCM8 is required for the stability of MCM9 protein in mammali... | The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. |
{"1016": 0.1064341589808464, "1037": 0.49864232540130615, "1039": 0.19782574474811554, "1996": 0.22001366317272186, "1998": 0.3163207769393921, "1999": 0.05970508232712746, "2000": 0.09495500475168228, "2003": 0.30558720231056213, "2005": 0.15777134895324707, "2007": 0.10731173306703568, "2022": 0.02316705882549286, "2... | 38296571 | The present invention provides a combination sink and dishwashing apparatus having a sink sharing a common side wall with a cabinet which defines a closed space. The cabinet has a wire basket for holding and washing a plurality of dishes within the cabinet. The common side wall is a part of the cabinet that defines the... | The 5TMM series: a useful in vivo mouse model of human multiple myeloma. |
{"1009": 0.1994270235300064, "1011": 0.23015019297599792, "1052": 0.5612884759902954, "1996": 0.11691460013389587, "1997": 0.13670019805431366, "1998": 0.2667117714881897, "1999": 0.37304413318634033, "2007": 0.5607312321662903, "2008": 0.030771657824516296, "2011": 0.4556184411048889, "2015": 0.5127768516540527, "2024... | 38300781 | Phospholipids are the major components of cell membranes, but they have functional roles beyond forming lipid bilayers. In particular, acidic phospholipids form microdomains in the plasma membrane and can ionically interact with proteins via polybasic sequences, which can have functional consequences for the protein. T... | Ionic protein-lipid interaction at the plasma membrane: what can the charge do? |
{"1011": 0.26146242022514343, "1022": 0.02887592278420925, "1043": 0.7454653382301331, "1055": 0.12728634476661682, "1057": 0.2478361576795578, "1060": 0.10906458646059036, "2003": 0.1485546976327896, "2008": 0.07612881064414978, "2011": 0.3191637098789215, "2029": 0.3241194784641266, "2058": 0.5729197263717651, "2075"... | 38355793 | OBJECTIVE A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells. This study investigates A20 expression in human glioma tissues and four glioma cell lines, and its effect on tumorigenesis of glioma cells and a mouse tumor model. METHODS Human glioma ti... | A20 is overexpressed in glioma cells and may serve as a potential therapeutic target. |
{"1011": 0.06703783571720123, "1019": 0.06429435312747955, "1052": 0.347847044467926, "1056": 0.04767346754670143, "2000": 0.07793712615966797, "2005": 0.5914691090583801, "2007": 0.21687394380569458, "2029": 0.11604541540145874, "2031": 0.1693800985813141, "2042": 0.05139094591140747, "2053": 0.22157983481884003, "206... | 38369817 | BACKGROUND Transcranial contrast Doppler studies have shown an increased prevalence of right-to-left shunts in patients with migraine with aura compared with controls. The anatomy and size of these right-to-left shunts have never been directly assessed. METHODS In a cross-sectional case-control study, the authors perfo... | Prevalence and size of directly detected patent foramen ovale in migraine with aura. |
{"1040": 0.42735910415649414, "1050": 0.08782484382390976, "1054": 0.8374842405319214, "1057": 0.29473719000816345, "1059": 1.1888195276260376, "2003": 0.2231435477733612, "2005": 0.24401791393756866, "2012": 0.1913948506116867, "2043": 0.2969166338443756, "2054": 0.052318159490823746, "2062": 0.15777134895324707, "207... | 38376189 | West Nile virus (WNV) is a major cause of mosquito-borne illness in the United States. Human disease ranges from mild febrile illness to severe fatal neurologic infection. Adults aged >60 years are more susceptible to neuroinvasive disease accompanied by a high mortality rate or long-lasting neurologic sequelae. A chim... | A Live Attenuated Chimeric West Nile Virus Vaccine, rWN/DEN4&Dgr;30, Is Well Tolerated and Immunogenic in Flavivirus-Naive Older Adult Volunteers |
{"1011": 0.3519764244556427, "1042": 0.6265231370925903, "1996": 0.46117570996284485, "1998": 0.040196798741817474, "2011": 0.1808556467294693, "2012": 0.22626367211341858, "2026": 0.9256220459938049, "2029": 0.06337817758321762, "2037": 0.15693697333335876, "2042": 0.0317181795835495, "2046": 0.34577593207359314, "206... | 38380061 | As organisms develop, their tissues can become separated into distinct cell populations through the establishment of compartment boundaries. Compartment boundaries have been discovered in a wide variety of tissues, but in many cases the molecular mechanisms that separate cells remain poorly understood. In the Drosophil... | Localization and requirement for Myosin II at the dorsal-ventral compartment boundary of the Drosophila wing. |
{"1011": 0.19862671196460724, "1013": 0.012615402229130268, "1015": 0.36426326632499695, "1018": 0.176772341132164, "1019": 0.18492233753204346, "1022": 0.10555581003427505, "1040": 0.30558720231056213, "1042": 0.1905880719423294, "1043": 0.4512746334075928, "1045": 0.2969166338443756, "1047": 0.5415972471237183, "1052... | 38401028 | 1. The changes in the metabolite content in freeze-clamped livers of fed rats occurring on perfusion with 10mm-d-fructose have been examined. 2. The most striking effects of fructose were an accumulation of fructose 1-phosphate, as already known, up to 8.7mumol/g of liver within 10min, a loss of total adenine nucleotid... | The cause of hepatic accumulation of fructose 1-phosphate on fructose loading. |
{"1003": 0.2990913391113281, "1014": 0.06154331564903259, "1019": 0.009718249551951885, "2004": 0.04394211992621422, "2007": 0.22001366317272186, "2033": 0.9052929878234863, "2043": 0.06703783571720123, "2053": 0.1710275560617447, "2062": 0.2561853528022766, "2063": 0.22704219818115234, "2080": 0.42735910415649414, "20... | 38410121 | BACKGROUND The aim of the study was to provide data on the relative frequency of reported symptoms in travelers using chloroquine, chloroquine plus proguanil, and mefloquine. METHOD The study was an open, nonrandomized study recording self-reported events in travelers recruited consecutively from two travel clinics in ... | Reported side effects to chloroquine, chloroquine plus proguanil, and mefloquine as chemoprophylaxis against malaria in Danish travelers. |
{"1011": 0.1602703034877777, "1015": 0.04207121208310127, "1016": 0.10203468054533005, "1043": 0.1994270235300064, "1045": 0.6476961374282837, "1048": 0.5551415085792542, "1049": 0.8315495252609253, "1057": 0.8247235417366028, "1059": 0.11951763927936554, "1997": 0.03266380727291107, "1999": 0.03266380727291107, "2002"... | 38477436 | Human cytomegalovirus US2 and US11 target newly synthesized class I major histocompatibility complex (MHC) heavy chains for rapid degradation by the proteasome through a process termed dislocation. The presence of US2 induces the formation of class I MHC heavy chain conjugates of increased molecular weight that are rec... | Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. |
{"1011": 0.32553088665008545, "1013": 0.058784693479537964, "1017": 0.0752234235405922, "1019": 0.7445381283760071, "1047": 0.052318159490823746, "1052": 0.5668440461158752, "1056": 0.9463045597076416, "1999": 0.15023678541183472, "2003": 0.33953672647476196, "2005": 0.14095009863376617, "2008": 0.07159364968538284, "2... | 38485364 | Tks5/Fish is a scaffolding protein with five SH3 domains and one PX domain. In Src-transformed cells, Tks5/Fish localizes to podosomes, discrete protrusions of the ventral membrane. We generated Src-transformed cells with reduced Tks5/Fish levels. They no longer formed podosomes, did not degrade gelatin, and were poorl... | The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. |
{"1017": 0.05139094591140747, "1039": 0.020300358533859253, "1054": 0.6149744987487793, "2005": 0.5033760666847229, "2020": 0.052318159490823746, "2045": 0.3127557039260864, "2053": 0.08154398202896118, "2058": 0.7163142561912537, "2064": 0.15693697333335876, "2090": 0.3241194784641266, "2093": 0.06520967930555344, "21... | 38493521 | BACKGROUND While many treatments, including corticosteroid injections in and around the shoulder, are advocated to be of benefit for shoulder pain, few are of proven efficacy. This review of corticosteroid injections for shoulder pain is one in a series of reviews of varying interventions for shoulder disorders. OBJECT... | Corticosteroid injections for shoulder pain. |
{"1009": 0.6322478652000427, "1011": 0.20421554148197174, "1015": 0.16607704758644104, "1043": 0.004870930220931768, "1047": 0.6989894509315491, "1048": 0.3560888469219208, "1056": 0.9994535446166992, "2003": 0.06429435312747955, "2008": 0.0317181795835495, "2013": 0.026025565341114998, "2024": 0.28743788599967957, "20... | 38502066 | Thymic-derived natural T regulatory cells (Tregs) are characterized by functional and phenotypic heterogeneity. Recently, a small fraction of peripheral Tregs has been shown to express Klrg1, but it remains unclear as to what extent Klrg1 defines a unique Treg subset. In this study, we show that Klrg1(+) Tregs represen... | IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. |
{"1015": 0.3757305145263672, "1038": 0.5232481360435486, "1040": 0.14939609169960022, "1996": 0.5562619566917419, "2003": 0.29619070887565613, "2005": 0.12384103983640671, "2008": 0.25088030099868774, "2011": 0.3615458607673645, "2024": 0.045809537172317505, "2028": 0.14349138736724854, "2029": 0.3656192123889923, "205... | 38528892 | The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding... | The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast. |
{"1011": 0.175953671336174, "1015": 0.38574060797691345, "1047": 0.6709295511245728, "1050": 0.03266380727291107, "1055": 0.8715548515319824, "1996": 0.272677481174469, "2003": 0.14433705806732178, "2005": 0.07341018319129944, "2008": 0.16690383851528168, "2015": 0.3012613356113434, "2024": 0.3034266233444214, "2028": ... | 38533515 | The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates cat... | AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy |
{"1014": 0.5127768516540527, "1021": 0.18248429894447327, "1040": 1.2494091987609863, "1049": 0.045809537172317505, "1052": 0.2447827309370041, "2003": 0.004870930220931768, "2005": 0.11604541540145874, "2007": 0.1602703034877777, "2029": 0.1221139207482338, "2064": 0.016465263441205025, "2084": 0.5156965255737305, "20... | 38551172 | Mammographic density is a strong risk factor for breast cancer, but the underlying biology for this association is unknown. Studies suggest that vitamin D may reduce breast cancer risk and dietary vitamin D intake has been associated with reduced breast density. We conducted a case-control study nested within the Nurse... | Mammographic density, plasma vitamin D levels and risk of breast cancer in postmenopausal women. |
{"1011": 0.13670019805431366, "1015": 0.04767346754670143, "1016": 0.026976587250828743, "1038": 1.057410478591919, "1039": 0.4500300884246826, "1041": 0.6451379656791687, "1042": 0.5290185213088989, "1043": 0.7009293437004089, "1048": 0.45623743534088135, "1055": 0.7163142561912537, "1056": 0.6624060273170471, "2000":... | 38587347 | Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating into low-affinity plasma cells or, after organizing into a germinal center (GC), high-affinity plasma cells and memory B cells. Remarkably, each of these events occurs in association with ... | Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. |
{"1015": 0.022212404757738113, "2003": 0.26820653676986694, "2011": 0.304147332906723, "2039": 0.3127557039260864, "2064": 0.18411032855510712, "2065": 0.018384648486971855, "2071": 0.17840765416622162, "2076": 0.10467668622732162, "2135": 0.12814582884311676, "2197": 0.056018441915512085, "2205": 0.09495500475168228, ... | 38623601 | Autophagy is the principal catabolic response to nutrient starvation and is necessary to clear dysfunctional or damaged organelles, but excessive autophagy can be cytotoxic or cytostatic and contributes to cell death. Depending on the abundance of enzymes involved in molecule biosynthesis, cells can be dependent on upt... | Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells |
{"1011": 0.27786844968795776, "1014": 0.2830325961112976, "1017": 0.2852376699447632, "1052": 0.20501139760017395, "1054": 0.0009760859538801014, "1081": 0.9886114001274109, "1999": 0.1384023278951645, "2004": 0.043007105588912964, "2006": 0.05694137513637543, "2007": 0.3353555500507355, "2012": 0.6317287683486938, "20... | 38630735 | BACKGROUND Atherosclerotic plaques that lead to acute coronary syndromes often occur at sites of angiographically mild coronary-artery stenosis. Lesion-related risk factors for such events are poorly understood. METHODS In a prospective study, 697 patients with acute coronary syndromes underwent three-vessel coronary a... | A prospective natural-history study of coronary atherosclerosis. |
{"1014": 0.2034190446138382, "1052": 0.5729197263717651, "1055": 0.15275461971759796, "1057": 0.40285754203796387, "1999": 0.10818854719400406, "2000": 0.11517547070980072, "2001": 0.09672962874174118, "2006": 0.016465263441205025, "2020": 0.016465263441205025, "2043": 0.15442965924739838, "2082": 1.04512357711792, "20... | 38664102 | PURPOSE To examine the curricula of U.S. medical schools to assess the inclusion of women's health and gender-specific information and identify institutional characteristics associated with this content. METHOD Using data from the Association of American Medical Colleges' Curriculum Management and Information Tool (Cur... | What do medical schools teach about women's health and gender differences? |
{"1041": 0.2719337046146393, "1996": 0.026976587250828743, "1999": 0.0354953333735466, "2005": 0.058784693479537964, "2011": 0.06795065850019455, "2013": 0.2822965085506439, "2029": 0.08961215615272522, "2031": 0.0058422754518687725, "2034": 0.08064348995685577, "2064": 0.18329764902591705, "2070": 0.1889725625514984, ... | 38675228 | Plants and some animals have a profound capacity to regenerate organs from adult tissues. Molecular mechanisms for regeneration have, however, been largely unexplored. Here we investigate a local regeneration response in Arabidopsis roots. Laser-induced wounding disrupts the flow of auxin-a cell-fate-instructive plant ... | A molecular framework for plant regeneration. |
{"1011": 0.259204238653183, "1014": 0.14179791510105133, "1015": 0.045809537172317505, "1017": 0.5925496220588684, "1020": 0.02792670577764511, "1021": 0.02316705882549286, "1026": 0.08782484382390976, "1041": 0.29109421372413635, "1042": 1.004473328590393, "1050": 0.04113444685935974, "1052": 0.27712854743003845, "105... | 38712515 | Evidence suggests that certain flavan-3-ols and procyanidins (FP) can have a positive influence on cardiovascular health. It has been previously reported that FP isolated from cocoa can potentially modulate the level and production of several signaling molecules associated with immune function and inflammation, includi... | Cocoa flavonols and procyanidins promote transforming growth factor-beta1 homeostasis in peripheral blood mononuclear cells. |
{"1017": 0.0038986403960734606, "1018": 0.3127557039260864, "1019": 0.0038986403960734606, "1038": 0.966567873954773, "1045": 0.1212492436170578, "1996": 0.5947071313858032, "2003": 0.3325583338737488, "2012": 0.07341018319129944, "2013": 0.31845372915267944, "2015": 0.02316705882549286, "2024": 0.12642613053321838, "2... | 38727075 | The neural crest is a multipotent, migratory cell population arising from the border of the neural and surface ectoderm. In mouse, the initial migratory neural crest cells occur at the five-somite stage. Bone morphogenetic proteins (BMPs), particularly BMP2 and BMP4, have been implicated as regulators of neural crest c... | BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. |
{"1011": 0.08692999184131622, "1014": 0.08961215615272522, "1016": 0.11951763927936554, "1017": 0.14686977863311768, "1019": 0.31489628553390503, "1020": 0.19541899859905243, "1044": 0.4950772523880005, "1050": 0.45623743534088135, "1051": 0.5438674688339233, "1052": 0.4041621685028076, "1058": 0.1602703034877777, "199... | 38735355 | Alveolar hypoxia and hypoxic vasoconstriction lead to trapping of sickle cells within the pulmonary vasculature. Improving alveolar ventilation and oxygenation may improve the outcome of acute chest syndrome (ACS). Prospective randomized single-center open study from November 1998 to February 2002 to test whether nonin... | Early intermittent noninvasive ventilation for acute chest syndrome in adults with sickle cell disease: a pilot study |
{"1009": 0.034552380442619324, "1048": 0.18329764902591705, "1049": 0.1619328260421753, "1060": 0.1011524572968483, "2000": 0.0606246218085289, "2004": 0.04113444685935974, "2005": 0.18248429894447327, "2007": 0.0606246218085289, "2026": 0.7239188551902771, "2029": 0.10203468054533005, "2033": 0.006812678650021553, "20... | 38745690 | Relapse remains the major cause of mortality for patients with Acute Myeloid Leukemia (AML). Improved tracking of minimal residual disease (MRD) holds the promise of timely treatment adjustments to preempt relapse. Current surveillance techniques detect circulating blasts that coincide with advanced disease and poorly ... | Serum Exosome MicroRNA as a Minimally-Invasive Early Biomarker of AML |
{"1011": 0.11430477350950241, "1044": 0.13157635927200317, "1045": 0.6128603219985962, "1048": 0.0752234235405922, "1049": 0.812664806842804, "2002": 0.012615402229130268, "2008": 0.12556517124176025, "2011": 0.3012613356113434, "2029": 0.33675122261047363, "2076": 0.0019512200960889459, "2091": 0.0606246218085289, "20... | 38747567 | Clinical and low passage strains of human CMV (HCMV) encode an additional MHC class I-related molecule UL142, in addition to the previously described UL18. The UL142 open reading frame is encoded within the ULb' region which is missing from a number of common high passage laboratory strains. Cells expressing UL142 foll... | Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that functions to inhibit NK cell lysis. |
{"1011": 0.11691460013389587, "1015": 0.04674193635582924, "1020": 0.11430477350950241, "1043": 0.3443928062915802, "1054": 1.0123108625411987, "1055": 0.3409265875816345, "1056": 0.5579402446746826, "1999": 0.03266380727291107, "2005": 0.04394211992621422, "2008": 0.06246116757392883, "2011": 0.7934166193008423, "2012... | 38751591 | The DELLA proteins GAI, RGA, RGL1 and RGL2 in Arabidopsis are plant growth repressors, repressing diverse developmental processes. Studies have shown that gibberellin (GA) attenuates the repressive function of DELLA proteins by triggering their degradation via the proteasome pathway. However, it is not known if GA-indu... | Identification of the conserved serine/threonine residues important for gibberellin-sensitivity of Arabidopsis RGL2 protein. |
{"1014": 0.1011524572968483, "1020": 0.10906458646059036, "1021": 0.1011524572968483, "1022": 0.06795065850019455, "1043": 0.06703783571720123, "1044": 0.3615458607673645, "1056": 0.33325836062431335, "2002": 0.029824240133166313, "2005": 0.47463157773017883, "2006": 0.29400965571403503, "2007": 0.2881702482700348, "20... | 38752049 | Youths with attention deficit hyperactivity disorder often experience weight loss on stimulants, which may limit optimal dosing and compliance. Cyproheptadine has been shown in medical samples to stimulate weight gain. We conducted a retrospective chart review of 28 consecutive pediatric psychiatry outpatients prescrib... | A chart review of cyproheptadine for stimulant-induced weight loss. |
{"1014": 0.5092619061470032, "1020": 0.10906458646059036, "1038": 0.43875885009765625, "1051": 0.43053874373435974, "2001": 0.03266380727291107, "2007": 0.12986256182193756, "2012": 0.0317181795835495, "2034": 0.5914691090583801, "2043": 0.10203468054533005, "2053": 0.05046287178993225, "2082": 0.10555581003427505, "20... | 38784540 | Objective To determine whether risk factors in childhood and early adulthood affect later mammographic breast density. Methods: Subjects were 628 women who attended a medical examination at the University of Glasgow Student Health Service (1948–1968), responded to a questionnaire (2001) and had a screening mammogram in... | Life course breast cancer risk factors and adult breast density (United Kingdom) |
{"1011": 0.13414156436920166, "1038": 0.6608943343162537, "1051": 0.5278670787811279, "1061": 0.8039615154266357, "2007": 0.1212492436170578, "2011": 0.30989447236061096, "2013": 0.38574060797691345, "2026": 1.0080435276031494, "2029": 0.07884006202220917, "2062": 0.06795065850019455, "2064": 0.29981520771980286, "2069... | 38793927 | A major clinical manifestation of bone cancers is bone destruction. It is widely accepted that this destruction is not caused by the malignant cells themselves, but by osteoclasts, multinucleated cells of monocytic origin that are considered to be the only cells able to degrade bone. The present study demonstrates that... | Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: a new type of cancer-host partnership? |
{"1017": 0.0797421783208847, "1051": 0.23324857652187347, "2011": 0.16442140936851501, "2015": 0.22392450273036957, "2029": 0.014542185701429844, "2034": 0.07612881064414978, "2044": 0.0752234235405922, "2046": 0.006812678650021553, "2048": 0.016465263441205025, "2051": 0.3956514894962311, "2061": 0.08961215615272522, ... | 38794814 | The human ability to continuously track dynamic environmental stimuli, in particular speech, is proposed to profit from "entrainment" of endogenous neural oscillations, which involves phase reorganization such that "optimal" phase comes into line with temporally expected critical events, resulting in improved processin... | Frequency modulation entrains slow neural oscillations and optimizes human listening behavior. |
{"1003": 0.2741633653640747, "1022": 0.15442965924739838, "1023": 0.1221139207482338, "1047": 0.3750596046447754, "1051": 0.22548456490039825, "1052": 0.23092569410800934, "1997": 0.175953671336174, "2000": 0.010684899985790253, "2001": 0.1751343309879303, "2009": 0.09584271162748337, "2011": 0.4132472574710846, "2015"... | 38799797 | Interventions by the pharmacists have always been considered as a valuable input by the health care community in the patient care process by reducing the medication errors, rationalizing the therapy and reducing the cost of therapy. The primary objective of this study was to determine the number and types of medication... | Interventions by pharmacists in out-patient pharmaceutical care. |
{"1009": 0.1401015669107437, "1014": 0.1221139207482338, "1057": 0.056018441915512085, "1997": 0.08782484382390976, "1999": 0.0842406153678894, "2001": 0.026976587250828743, "2002": 0.3588210940361023, "2003": 0.18492233753204346, "2004": 0.14179791510105133, "2005": 0.1011524572968483, "2011": 0.04674193635582924, "20... | 38805486 | Nickel is a fundamental micronutrient for cellular life, but it is toxic in soluble form at nonphysiological concentrations. Such potentially contradictory features required living organisms to develop efficient systems for nickel utilization and homeostasis. This is the case for incorporation of nickel into the active... | Biochemical studies on Mycobacterium tuberculosis UreG and comparative modeling reveal structural and functional conservation among the bacterial UreG family. |
{"1011": 0.06886265426874161, "1015": 0.052318159490823746, "1019": 0.22157983481884003, "1043": 0.6911921501159668, "1155": 0.7276995778083801, "1999": 0.009718249551951885, "2003": 0.18816383183002472, "2005": 0.3743882179260254, "2010": 0.8074519634246826, "2015": 0.2696990668773651, "2024": 0.24018502235412598, "20... | 38808600 | Integrins, a large family of cell adhesion receptors, have been shown to play an important role for glioma proliferation and invasion. Several integrin receptors, including αvβ3, αvβ5, and α5β1, have generated clinical interest for glioma diagnosis and antitumor therapy. Integrin α5β1 has been highlighted as a prognost... | (99m)Tc-HisoDGR as a Potential SPECT Probe for Orthotopic Glioma Detection via Targeting of Integrin α5β1. |
{"1020": 0.19381128251552582, "1021": 0.13157635927200317, "1038": 0.8065804839134216, "1043": 0.14095009863376617, "1058": 0.42735910415649414, "1997": 0.17267228662967682, "1999": 0.09938567131757736, "2002": 0.026976587250828743, "2004": 0.10906458646059036, "2007": 0.1358480453491211, "2011": 0.2990913391113281, "2... | 38811597 | Tyrosine hydroxylase (TH, EC 1.14.16.2) from beef brain striata was purified 23-fold from an extract of an acetone powder. If this enzyme preparation is treated with a cyclic AMP[-dependent protein phosphorylation system, there is a change in the pH dependence of the enzyme activity. The pH optimum at saturating tetrah... | Effect of cyclic AMP-dependent protein phosphorylating conditions on the pH-dependent activity of tyrosine hydroxylase from beef and rat striata. |
{"1009": 0.37907835841178894, "1011": 0.13755162060260773, "1020": 0.10026945173740387, "1042": 0.11778303235769272, "1056": 0.49626702070236206, "2007": 0.15275461971759796, "2011": 0.3963087201118469, "2029": 0.3012613356113434, "2038": 0.1401015669107437, "2039": 0.36358460783958435, "2058": 0.0174254160374403, "206... | 38830961 | Although TNF is a major proinflammatory cytokine, increasing evidence indicates that TNF also has immunosuppressive feedback effects. We have demonstrated in this study that, in both resting and activated states, mouse peripheral CD4(+)CD25(+) T regulatory cells (Tregs) expressed remarkably higher surface levels of TNF... | Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells. |
{"1011": 0.3864043951034546, "1041": 0.34715715050697327, "1996": 0.3241194784641266, "1998": 0.26146242022514343, "2011": 0.2990913391113281, "2029": 0.02887592278420925, "2033": 0.9409833550453186, "2066": 0.0770333781838417, "2076": 0.1718502640724182, "2079": 0.2531573474407196, "2090": 0.036437395960092545, "2102"... | 38844612 | The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emerging evidence suggests that epithelial-mesenchymal transitions (EMTs) represent one important source of these cells. As we disc... | The basics of epithelial-mesenchymal transition. |
{"1011": 0.11951763927936554, "1018": 0.11951763927936554, "1038": 0.15526613593101501, "1040": 0.5421652793884277, "1998": 0.27044451236724854, "2001": 0.06886265426874161, "2005": 0.07068414986133575, "2007": 0.5110208988189697, "2020": 0.259204238653183, "2029": 0.0770333781838417, "2041": 0.5104349255561829, "2044"... | 38873881 | Consecutive child psychiatric outpatient admissions with disruptive behavior or adjustment disorders were assessed by validated instruments for trauma exposure and posttraumatic stress disorder (PTSD) symptoms and other psychopathology. Four reliably diagnosed groups were defined in a retrospective case-control design:... | Child maltreatment, other trauma exposure, and posttraumatic symptomatology among children with oppositional defiant and attention deficit hyperactivity disorders. |
{"1039": 0.5057345628738403, "1041": 0.8877626657485962, "1042": 0.9029204845428467, "1052": 0.9294845461845398, "2000": 0.04953393340110779, "2005": 0.01934296265244484, "2007": 0.11256109178066254, "2020": 0.0019512200960889459, "2023": 0.00875066313892603, "2029": 0.007782140281051397, "2044": 0.20102575421333313, "... | 38882175 | PURPOSE The purpose of this study was to compare a laboratory based exercise challenge (LBC) to a field based exercise challenge (FBC) for pulmonary function test (PFT) exercise-induced asthma (EIA) screening of elite athletes. METHODS Twenty-three elite cold weather athletes (14 men, 9 women) PFT positive for EIA (FBC... | Exercise-induced asthma screening of elite athletes: field versus laboratory exercise challenge. |
{"1011": 0.5551415085792542, "1014": 0.08244366943836212, "1017": 0.1212492436170578, "1018": 0.34922540187835693, "1023": 0.10731173306703568, "1041": 0.24631060659885406, "1045": 0.015504186972975731, "1046": 1.227902889251709, "1052": 0.5651806592941284, "1053": 0.08961215615272522, "1060": 0.21293537318706512, "106... | 38886345 | BACKGROUND JX-594 is a targeted oncolytic poxvirus designed to selectively replicate in and destroy cancer cells with cell-cycle abnormalities and epidermal growth factor receptor (EGFR)-ras pathway activation. Direct oncolysis plus granulocyte-macrophage colony-stimulating factor (GM-CSF) expression also stimulates sh... | Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial. |
{"1009": 0.32553088665008545, "1011": 0.304147332906723, "1017": 0.06520967930555344, "1021": 0.47584590315818787, "1038": 1.013020396232605, "1045": 0.450652539730072, "1048": 0.5461324453353882, "1051": 0.5865923762321472, "1052": 0.19622190296649933, "1996": 0.015504186972975731, "1999": 0.13755162060260773, "2005":... | 38899659 | Cells of the osteoblast lineage provide critical support for B lymphopoiesis in the bone marrow (BM). Parathyroid hormone (PTH) signaling in osteoblastic cells through its receptor (PPR) is an important regulator of hematopoietic stem cells; however, its role in regulation of B lymphopoiesis is not clear. Here we demon... | PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization. |
{"1043": 0.6999598741531372, "1052": 0.5557019114494324, "1996": 0.176772341132164, "2011": 0.33325836062431335, "2025": 0.1221139207482338, "2029": 0.22548456490039825, "2037": 0.45623743534088135, "2046": 0.34508460760116577, "2048": 0.4980490207672119, "2079": 0.3615458607673645, "2091": 0.3750596046447754, "2117": ... | 38919140 | The Snail transcription factor plays a key role in regulating diverse developmental processes but is not thought to play a role in mammalian neural precursors. Here, we have examined radial glial precursor cells of the embryonic murine cortex and demonstrate that Snail regulates their survival, self-renewal, and differ... | Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development. |
{"1011": 0.18816383183002472, "1040": 0.14179791510105133, "1047": 1.1653456687927246, "1048": 0.9922385215759277, "2003": 0.27786844968795776, "2008": 0.18978065252304077, "2011": 0.32764431834220886, "2012": 0.020300358533859253, "2029": 0.14433705806732178, "2066": 0.7182208299636841, "2076": 0.053244512528181076, "... | 38944245 | Lung Krüppel-like factor (LKLF/KLF2) is an endothelial transcription factor that is crucially involved in murine vasculogenesis and is specifically regulated by flow in vitro. We now show a relation to local flow variations in the adult human vasculature: decreased LKLF expression was noted at the aorta bifurcations to... | Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. |
{"1045": 0.28082266449928284, "1060": 0.1485546976327896, "1999": 0.129004567861557, "2005": 0.03266380727291107, "2013": 0.04674193635582924, "2029": 0.1602703034877777, "2035": 0.2447827309370041, "2046": 0.23015019297599792, "2063": 1.1858406066894531, "2064": 0.46055975556373596, "2071": 0.045809537172317505, "2079... | 39048693 | The cre/LoxP system can produce conditional loss of gene function in specific cell types such as neurons. A transgenic mouse line, utilized by multiple studies, used the Synapsin I promoter to drive expression of cre (SynCre) to achieve neuronal-specific cre expression. Herein we describe that cre expression can also b... | Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. |
{"1003": 0.23092569410800934, "1011": 0.21135559678077698, "1014": 0.18654440343379974, "1021": 0.14095009863376617, "1052": 0.09406650811433792, "1997": 0.2447827309370041, "2001": 0.12038381397724152, "2007": 0.17020416259765625, "2030": 0.2105647772550583, "2043": 0.020300358533859253, "2063": 0.7191727757453918, "2... | 39059143 | CONTEXT The association of an adult tele-intensive care unit (ICU) intervention with hospital mortality, length of stay, best practice adherence, and preventable complications for an academic medical center has not been reported. OBJECTIVE To quantify the association of a tele-ICU intervention with hospital mortality, ... | Hospital mortality, length of stay, and preventable complications among critically ill patients before and after tele-ICU reengineering of critical care processes. |
{"1006": 0.0029254043474793434, "1009": 0.5947071313858032, "1011": 0.31560876965522766, "1039": 0.20977331697940826, "1041": 0.5898461937904358, "1044": 0.17020416259765625, "1051": 0.306306391954422, "1056": 0.736154317855835, "1999": 0.39762192964553833, "2004": 0.09406650811433792, "2007": 0.04953393340110779, "201... | 39084565 | Experimental autoimmune myocarditis (EAM) represents a Th17 T cell-mediated mouse model of postinflammatory heart disease. In BALB/c wild-type mice, EAM is a self-limiting disease, peaking 21 days after alpha-myosin H chain peptide (MyHC-alpha)/CFA immunization and largely resolving thereafter. In IFN-gammaR(-/-) mice,... | CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. |
{"1996": 0.7086513638496399, "2005": 0.16690383851528168, "2011": 0.4330752193927765, "2015": 0.022212404757738113, "2029": 0.2160874605178833, "2063": 0.07068414986133575, "2073": 0.04767346754670143, "2076": 0.05786345899105072, "2079": 0.18654440343379974, "2112": 0.06154331564903259, "2140": 0.8796916007995605, "22... | 39128592 | The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that th... | The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. |
{"1009": 0.8315495252609253, "1011": 0.175953671336174, "1040": 0.49686139822006226, "1045": 0.495672345161438, "1052": 0.2105647772550583, "1056": 0.5278670787811279, "1156": 0.5295937061309814, "1996": 0.04487626627087593, "1997": 0.025073638185858727, "1999": 0.1710275560617447, "2004": 0.10203468054533005, "2008": ... | 39164524 | Accumulation of adipocytes and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies. The origin of these cells had been largely unknown, but recently we identified mesenchymal progenitors positive for platelet-derived growth factor receptor alpha (PDGFRα) as the origin of adipocytes in skeleta... | Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle. |
{"1015": 0.11430477350950241, "1039": 0.9115922451019287, "1041": 0.9754437208175659, "1045": 0.2852376699447632, "1996": 0.07159364968538284, "1997": 0.10731173306703568, "1999": 0.09850110858678818, "2000": 0.22626367211341858, "2004": 0.0770333781838417, "2005": 0.0029254043474793434, "2015": 0.08603433519601822, "2... | 39174007 | Free radicals vary widely in their thermodynamic properties, ranging from very oxidizing to very reducing. These thermodynamic properties can be used to predict a pecking order, or hierarchy, for free radical reactions. Using one-electron reduction potentials, the predicted pecking order is in agreement with experiment... | The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. |
{"1009": 0.5789587497711182, "1013": 0.0770333781838417, "1014": 0.4556184411048889, "1017": 0.1685553640127182, "1026": 0.07431721687316895, "1040": 0.37102460861206055, "1043": 0.6011518239974976, "1051": 0.36086538434028625, "1052": 0.2247048318386078, "1055": 0.23015019297599792, "2007": 0.12470348179340363, "2012"... | 39187170 | Adipose tissue exerts important endocrine and metabolic functions in health and disease. Yet the bioenergetics of this tissue is not characterized in humans and possible regional differences are not elucidated. Using high resolution respirometry, mitochondrial respiration was quantified in human abdominal subcutaneous ... | Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. |
{"1011": 0.18167030811309814, "1038": 1.1121915578842163, "1042": 0.46117570996284485, "1044": 0.5127768516540527, "1056": 0.03360854089260101, "2002": 0.817850649356842, "2006": 0.11604541540145874, "2007": 0.009718249551951885, "2010": 0.762009859085083, "2012": 0.176772341132164, "2029": 0.12642613053321838, "2072":... | 39225849 | The Bloom syndrome helicase (BLM) is critical for genomic stability. A defect in BLM activity results in the cancer-predisposing Bloom syndrome (BS). Here, we report that BLM-deficient cell lines and primary fibroblasts display an endogenously activated DNA double-strand break checkpoint response with prominent levels ... | Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks. |
{"1009": 0.0029254043474793434, "1011": 0.22704219818115234, "1014": 0.4481603503227234, "1019": 0.009718249551951885, "1020": 0.7286425232887268, "1023": 0.05694137513637543, "1038": 0.5450005531311035, "1042": 0.36426326632499695, "1049": 0.004870930220931768, "1052": 0.6563454270362854, "1054": 0.7426811456680298, "... | 39264456 | OBJECTIVES We investigated the role of cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in cachexia development in newly diagnosed nonsmall cell lung cancer (NSCLC) patients. METHODS : We evaluated 44 (M/F:41/3) NSCLC patients and 12 (M/F:10/2) age matched healthy smokers. NSCLC cases with a w... | Impact of TNF-alpha and IL-6 levels on development of cachexia in newly diagnosed NSCLC patients. |
{"1011": 0.48610860109329224, "1039": 0.7009293437004089, "1040": 0.7201237678527832, "1041": 0.4580921530723572, "1050": 0.036437395960092545, "2003": 0.20022670924663544, "2005": 0.14939609169960022, "2007": 0.25995752215385437, "2051": 0.11081436276435852, "2077": 0.6228629946708679, "2086": 0.1685553640127182, "209... | 39281140 | CONTEXT Sexual dysfunction is a common adverse effect of antidepressants that frequently results in treatment noncompliance. OBJECTIVE To assess the efficacy of sildenafil citrate in men with sexual dysfunction associated with the use of selective and nonselective serotonin reuptake inhibitor (SRI) antidepressants. DES... | Treatment of antidepressant-associated sexual dysfunction with sildenafil: a randomized controlled trial. |
{"1011": 0.33675122261047363, "1039": 0.1685553640127182, "1043": 0.045809537172317505, "1996": 0.03266380727291107, "1999": 0.04113444685935974, "2008": 0.03831886500120163, "2011": 0.0174254160374403, "2012": 0.05694137513637543, "2015": 0.42353010177612305, "2024": 0.02887592278420925, "2029": 0.30558720231056213, "... | 39281166 | Mammalian genomes are extensively transcribed outside the borders of protein-coding genes. Genome-wide studies recently demonstrated that cis-regulatory genomic elements implicated in transcriptional control, such as enhancers and locus-control regions, represent major sites of extragenic noncoding transcription. Enhan... | Noncoding transcription at enhancers: general principles and functional models. |
{"1048": 0.025073638185858727, "1052": 1.0361549854278564, "1055": 0.6080870032310486, "1999": 0.00875066313892603, "2003": 0.29109421372413635, "2008": 0.0058422754518687725, "2011": 0.28155985474586487, "2013": 0.5220900774002075, "2034": 0.33605360984802246, "2057": 0.7276995778083801, "2063": 0.5540198087692261, "2... | 39285547 | Streptococcus pneumoniae is a leading cause of invasive bacterial disease. This is the first study to examine the expression of S. pneumoniae genes in vivo by using whole-genome microarrays available from The Institute for Genomic Research. Total RNA was collected from pneumococci isolated from infected blood, infected... | Microarray analysis of pneumococcal gene expression during invasive disease. |
{"1011": 0.11951763927936554, "1038": 0.7537717819213867, "1042": 0.6128603219985962, "1045": 0.520350456237793, "1060": 0.40285754203796387, "1996": 0.021256839856505394, "1998": 0.083342544734478, "2007": 0.22937409579753876, "2011": 0.32341301441192627, "2012": 0.5162794589996338, "2029": 0.2501201331615448, "2033":... | 39291138 | Cells develop by reading mixed signals. Nowhere is this clearer than in the highly dynamic processes that propel embryogenesis, when critical cell-fate decisions are made swiftly in response to well-orchestrated growthfactor combinations. Learning how diverse signaling pathways are integrated is therefore essential for... | Integration of Smad and MAPK pathways: a link and a linker revisited. |
{"1003": 0.23787821829319, "1050": 0.255429208278656, "1052": 0.08782484382390976, "1997": 0.08871890604496002, "1999": 0.13243216276168823, "2001": 0.10379679501056671, "2011": 0.0009760859538801014, "2020": 0.34715715050697327, "2043": 0.05139094591140747, "2044": 0.18978065252304077, "2051": 0.4950772523880005, "206... | 39300105 | Selected clinical pharmacy interventions undertaken during a 30-day data capture period were analysed, seeking to gain a greater understanding of the nature of the drug-related problems involved. Pharmacists were asked to record only interventions that were of potentially major significance. A total of 67 interventions... | A brief analysis of clinical pharmacy interventions undertaken in an Australian teaching hospital. |
{"1048": 0.3870677351951599, "1998": 0.0009760859538801014, "2002": 0.08064348995685577, "2010": 0.6118015646934509, "2012": 0.09317722171545029, "2018": 0.04860413447022438, "2020": 0.0606246218085289, "2026": 0.5318912267684937, "2044": 0.44753631949424744, "2064": 0.3141832649707794, "2065": 0.045809537172317505, "2... | 39304380 | Simultaneous parenteral vaccination against typhoid and cholera lead to death through either anaphylactic shock or endotoxic shock in a 36-year-old male. At autopsy the charactertic features of shock as well as chronic interstitial myocarditis were noted. Moreover, fresh histiocytic and lymphocytic nodules were found i... | Lethal complications of typhoid-cholera-vaccination. (Case report and review of the literature). |
{"1042": 0.021256839856505394, "1043": 0.3683255612850189, "1052": 0.03831886500120163, "1998": 0.3077431619167328, "2028": 0.09050461649894714, "2038": 0.26296505331993103, "2042": 0.2145126610994339, "2047": 0.7028654217720032, "2049": 0.04113444685935974, "2054": 0.037378571927547455, "2064": 0.09317722171545029, "2... | 39326723 | Substantial progress in functional genomic and proteomic technologies has opened new perspectives in biomedical research. The sequence of the human genome has been mostly determined and opened new visions on its complexity and regulation. New technologies, like RNAi and protein arrays, allow gathering knowledge beyond ... | Functional genomics and proteomics approaches to study the ERBB network in cancer. |
{"1050": 0.20660123229026794, "2000": 0.025073638185858727, "2001": 0.06429435312747955, "2003": 0.16359257698059082, "2005": 0.09938567131757736, "2043": 0.25845035910606384, "2047": 0.04767346754670143, "2054": 0.05046287178993225, "2058": 0.07341018319129944, "2064": 0.05694137513637543, "2073": 0.12814582884311676,... | 39334724 | Spatial filters have been used as an easy and intuitive way to create smoothed disease maps. Birth weight data from New York State for 1994 and 1995 are used to compare the traditional filter type of fixed geographical size with a filter size of constant or nearly constant population size. The latter are more appropria... | Evaluation of spatial filters to create smoothed maps of health data. |
{"1014": 0.1889725625514984, "1043": 0.2822965085506439, "1044": 0.5855054259300232, "1050": 0.11865071207284927, "1052": 0.1332872211933136, "2001": 0.42353010177612305, "2005": 0.0317181795835495, "2018": 0.10203468054533005, "2020": 0.3883931338787079, "2031": 0.13157635927200317, "2034": 0.35060185194015503, "2035"... | 39368721 | OBJECTIVE to investigate the role of glucose tolerance in the development of hypertension. DESIGN Retrospective analysis of the results of a health check up in a group of clinically healthy middle aged men in the late 1960s (median year 1968). The subjects were invited to enter into a primary prevention trial for cardi... | Glucose tolerance and blood pressure: long term follow up in middle aged men. |
{"1011": 0.41195443272590637, "1015": 0.17759032547473907, "1016": 0.42544642090797424, "1038": 0.5341835021972656, "1039": 0.6999598741531372, "1996": 0.11430477350950241, "1998": 0.04487626627087593, "1999": 0.11168810725212097, "2005": 0.2719337046146393, "2007": 0.1229778528213501, "2008": 0.14686977863311768, "201... | 39381118 | Apoptosis that proceeds via the mitochondrial pathway involves mitochondrial outer membrane permeabilization (MOMP), responsible for the release of cytochrome c and other proteins of the mitochondrial intermembrane space. This essential step is controlled and mediated by proteins of the Bcl-2 family. The proapoptotic p... | At the gates of death. |
{"1011": 0.08782484382390976, "1015": 0.6181373596191406, "1038": 0.5410289764404297, "1044": 0.9348671436309814, "1997": 0.17431432008743286, "1998": 0.10026945173740387, "1999": 0.0770333781838417, "2002": 0.26296505331993103, "2007": 0.2105647772550583, "2008": 0.053244512528181076, "2011": 0.3339579105377197, "2028... | 39389082 | We report here crystal structures of human RNase H1 complexed with an RNA/DNA substrate. Unlike B. halodurans RNase H1, human RNase H1 has a basic protrusion, which forms a DNA-binding channel and together with the conserved phosphate-binding pocket confers specificity for the B form and 2'-deoxy DNA. The RNA strand is... | Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. |
{"1011": 0.5127768516540527, "1014": 0.18004031479358673, "1040": 0.23092569410800934, "1042": 0.11951763927936554, "1052": 0.2447827309370041, "1056": 0.6563454270362854, "2002": 0.15023678541183472, "2007": 0.22548456490039825, "2010": 0.9386941194534302, "2019": 0.49923527240753174, "2048": 0.19381128251552582, "205... | 39390206 | OBJECTIVE To measure in vivo, using diffusion tensor magnetic resonance imaging (DT-MRI) the extent of pathological damage of normal appearing brain tissue (NABT) from patients with migraine. METHODS Dual echo and DT-MRI scans of the brain were acquired from 34 patients with migraine and 17 sex and age matched healthy ... | A diffusion tensor magnetic resonance imaging study of brain tissue from patients with migraine. |
{"1011": 0.6170841455459595, "1038": 0.3127557039260864, "1999": 0.1913948506116867, "2000": 0.0797421783208847, "2001": 0.026025565341114998, "2003": 0.055094651877880096, "2005": 0.1889725625514984, "2007": 0.04394211992621422, "2029": 0.02792670577764511, "2062": 0.1229778528213501, "2064": 0.02412080205976963, "207... | 39391953 | A sensitive biotin-streptavidin amplified enzyme-linked immunosorbent assay (BA-ELISA) method was developed for the determination of chloramphenicol residues in milk. The biotin-streptavidin system was applied to enhance the sensitivity. After optimization, the detection limit of the method was found to be 0.042 +/- 0.... | Determination of chloramphenicol residues in milk by enzyme-linked immunosorbent assay: improvement by biotin-streptavidin-amplified system. |
{"1011": 0.1930064558982849, "1046": 0.5696102976799011, "1048": 0.7656494975090027, "1050": 0.272677481174469, "1052": 0.030771657824516296, "1155": 0.0317181795835495, "1164": 0.1619328260421753, "2002": 0.6882523894309998, "2003": 0.45251765847206116, "2005": 0.4462870955467224, "2011": 0.15610189735889435, "2029": ... | 39424916 | Wedelolactone is a major coumarin of Eclipta prostrata, which is used for preventing liver damage. However the effects of wedelolactone on hepatic fibrosis remained unexplored. The purpose of this study was to demonstrate the anti-fibrotic effects of wedelolactone on activated human hepatic stellate cell (HSC) line LX-... | Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2. |
{"1011": 0.371698260307312, "1017": 0.10291612148284912, "1043": 0.8315495252609253, "1054": 0.3777405619621277, "1155": 0.9761797785758972, "1156": 0.3622259199619293, "1999": 0.10467668622732162, "2004": 0.7881022095680237, "2006": 0.14518201351165771, "2007": 0.3019835948944092, "2008": 0.03831886500120163, "2011": ... | 39426225 | Recent research has shown that adipose tissues contain abundant MSCs (mesenchymal stem cells). The origin and location of the adipose stem cells, however, remain unknown, presenting an obstacle to the further purification and study of these cells. In the present study, we aimed at investigating the origins of adipose s... | Adipose stem cells originate from perivascular cells. |
{"1011": 0.2976420819759369, "1014": 0.12814582884311676, "1015": 0.03266380727291107, "1018": 0.12814582884311676, "1044": 0.45499902963638306, "1048": 0.6353566646575928, "1052": 0.2830325961112976, "1056": 0.9936857223510742, "1062": 0.6907027959823608, "2001": 0.011650617234408855, "2003": 0.29328158497810364, "200... | 39443128 | Adult T-cell leukaemia lymphoma (ATLL) is an aggressive disease caused by the human T-lymphotropic virus 1 (HTLV-I) with a short survival. Responses to interferon alpha (IFN-alpha) and zidovudine (AZT) have been documented but not with long-term follow-up. We treated 15 ATLL patients with IFN and AZT. Eleven patients h... | Interferon alpha and zidovudine therapy in adult T-cell leukaemia lymphoma: response and outcome in 15 patients. |
{"1011": 0.1946154683828354, "1015": 0.18167030811309814, "1039": 1.0546929836273193, "1043": 0.14433705806732178, "1055": 0.4349733293056488, "2000": 0.846739649772644, "2008": 0.05786345899105072, "2011": 0.10555581003427505, "2012": 0.26146242022514343, "2025": 0.03831886500120163, "2029": 0.5104349255561829, "2049"... | 39462488 | Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Saccharomyces cerevisiae proteins Tof1 and Mrc1 facilitate replication fork progression through CGG repeats. Remarkably, th... | Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility |
{"1011": 0.12642613053321838, "1039": 0.37907835841178894, "1041": 0.39762192964553833, "1047": 0.5662899017333984, "2004": 0.026025565341114998, "2011": 0.3588210940361023, "2026": 0.8004589080810547, "2029": 0.20102575421333313, "2046": 0.44753631949424744, "2058": 0.1808556467294693, "2061": 0.9515975713729858, "206... | 39465575 | Recent studies have shown that defined sets of transcription factors can directly reprogram differentiated somatic cells to a different differentiated cell type without passing through a pluripotent state, but the restricted proliferative and lineage potential of the resulting cells limits the scope of their potential ... | Direct reprogramming of fibroblasts into neural stem cells by defined factors. |
{"1040": 0.22782009840011597, "1042": 0.39762192964553833, "1045": 0.10291612148284912, "1052": 0.3170322775840759, "2003": 0.1946154683828354, "2007": 0.040196798741817474, "2010": 0.6492279767990112, "2179": 0.037378571927547455, "2220": 0.20421554148197174, "2287": 0.2470736801624298, "2331": 0.3864043951034546, "23... | 39481265 | PURPOSE OF REVIEW Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options and extensive gene expression changes identified in the lung parenchyma. Multiple lines of evidence suggest that epigenetic factors contribute to dysregulation of gene expression in IPF lung. Most importantly, risk f... | Epigenetics in lung fibrosis: from pathobiology to treatment perspective. |
{"1011": 0.18004031479358673, "1015": 0.371698260307312, "1041": 0.30558720231056213, "1047": 1.202409029006958, "1048": 0.35813871026039124, "2003": 0.13499516248703003, "2008": 0.08961215615272522, "2011": 0.26820653676986694, "2013": 0.07159364968538284, "2019": 0.4203280806541443, "2028": 0.07068414986133575, "2029... | 39506601 | KLF1 (formerly known as EKLF) regulates the development of erythroid cells from bi-potent progenitor cells via the transcriptional activation of a diverse set of genes. Mice lacking Klf1 die in utero prior to E15 from severe anemia due to the inadequate expression of genes controlling hemoglobin production, cell membra... | Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq. |
{"1009": 0.2493593990802765, "1011": 0.0913962796330452, "1018": 0.10993985831737518, "1020": 0.013579257763922215, "1039": 0.4374985992908478, "1044": 0.0174254160374403, "1053": 0.688742995262146, "2000": 0.022212404757738113, "2005": 0.2089812457561493, "2007": 0.25694093108177185, "2015": 0.6233867406845093, "2034"... | 39532074 | INTRODUCTION The hostile environment after spinal cord injury (SCI) can compromise effects of regenerative therapies. We hypothesized that optimizing the post-traumatic environment with QL6 self-assembling peptides (SAPs) before neural precursor cell (NPC) transplantation would improve cell survival, differentiation an... | Self-assembling peptides optimize the post-traumatic milieu and synergistically enhance the effects of neural stem cell therapy after cervical spinal cord injury. |
{"1011": 0.4537591338157654, "1016": 0.23479416966438293, "1018": 0.06429435312747955, "1039": 0.5272908806800842, "1047": 0.5860490798950195, "1056": 0.637939989566803, "1998": 0.0752234235405922, "2004": 0.029824240133166313, "2005": 0.02887592278420925, "2007": 0.304147332906723, "2011": 0.3870677351951599, "2029": ... | 39539647 | IL-12 has been identified as a major cytokine influencing the differentiation of CD4 cells to a Th1 phenotype, whereas a role for IFN-gamma is controversial. We investigated the interrelationship between IL-12 and IFN-gamma in promoting Th1 responses using naive CD4 cells reactive with pigeon cytochrome c from TCR tran... | A direct role for IFN-gamma in regulation of Th1 cell development. |
{"1011": 0.029824240133166313, "1015": 0.5278670787811279, "1018": 0.0797421783208847, "1043": 0.25088030099868774, "1050": 0.22392450273036957, "1054": 0.1221139207482338, "2007": 0.14349138736724854, "2028": 0.1808556467294693, "2029": 0.37371641397476196, "2033": 0.7426811456680298, "2071": 0.19220098853111267, "208... | 39545358 | Neuregulin 1 (NRG1) and its receptor ErbB4 are both susceptibility genes of schizophrenia. However, little is known about the underlying mechanisms of their malfunction. Although ErbB4 is enriched in GABAergic interneurons, the role of NRG1 in excitatory synapse formation in these neurons remains poorly understood. We ... | Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. |
{"1009": 0.5313173532485962, "1011": 0.0354953333735466, "1020": 0.17840765416622162, "1039": 0.24554696679115295, "1044": 0.6400018334388733, "1052": 1.0030416250228882, "1056": 0.7942996621131897, "1156": 0.5876781344413757, "2002": 0.8649974465370178, "2004": 0.3910386264324188, "2007": 0.2034190446138382, "2011": 0... | 39550665 | BACKGROUND & AIMS Chronic infection with the bacterial pathogen Helicobacter pylori causes gastric disorders, ranging from chronic gastritis to gastric adenocarcinoma. Only a subset of infected persons will develop overt disease; most remains asymptomatic despite lifelong colonization. This study aims to elucidate the ... | Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. |
{"1020": 0.2837681770324707, "1039": 0.3248254358768463, "1043": 0.5855054259300232, "2007": 0.18004031479358673, "2029": 0.176772341132164, "2071": 0.11081436276435852, "2075": 0.014542185701429844, "2076": 0.04767346754670143, "2084": 0.0058422754518687725, "2093": 0.12728634476661682, "2098": 0.5941681861877441, "21... | 39558597 | Aging is associated with impaired fasted oxidation of nonesterified fatty acids (NEFA) suggesting a mitochondrial defect. Aging is also associated with deficiency of glutathione (GSH), an important mitochondrial antioxidant, and with insulin resistance. This study tested whether GSH deficiency in aging contributes to i... | Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione. |
{"1011": 0.12642613053321838, "1048": 0.34577593207359314, "1996": 0.15777134895324707, "1999": 0.08692999184131622, "2006": 0.10555581003427505, "2008": 0.022212404757738113, "2011": 0.3554046154022217, "2015": 0.0038986403960734606, "2029": 0.2539152204990387, "2038": 0.0019512200960889459, "2063": 1.0835250616073608... | 39559521 | The negative selection of self-reactive thymocytes depends on the expression of tissue-specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even one Aire-induced tissue-specific antigen in the thymus can ... | Control of central and peripheral tolerance by Aire. |
{"1043": 0.8534175157546997, "1044": 0.4481603503227234, "1057": 0.5957841277122498, "1996": 0.31132611632347107, "2011": 0.23092569410800934, "2012": 0.10555581003427505, "2029": 0.026976587250828743, "2043": 0.004870930220931768, "2049": 0.16442140936851501, "2076": 0.13670019805431366, "2079": 0.28082266449928284, "... | 39571812 | Reproductive function depends on the activity of the gonadotropic axis, which is controlled by a hypothalamic neural network whose main function is to regulate the secretion of gonadotropin-releasing hormone (GnRH). This endocrine network is not mature at birth, and several phases of activation-inactivation of the gona... | Congenital Hypogonadotropic Hypogonadism: A Trait Shared by Several Complex Neurodevelopmental Disorders. |
{"1011": 0.6064908504486084, "1017": 0.9084475636482239, "1040": 0.7028654217720032, "1049": 0.09672962874174118, "1055": 0.29619070887565613, "1056": 0.42161011695861816, "2003": 0.0174254160374403, "2005": 0.06520967930555344, "2029": 0.13157635927200317, "2058": 0.7665573358535767, "2079": 0.13243216276168823, "2093... | 39580129 | OBJECTIVES Several miRNAs are aberrantly expressed in cancer. miR-24-3p is involved in cancer-related cellular processes, including cell cycle control, cell growth, proliferation, and apoptosis. In this study, we examined the potential diagnostic and prognostic significance of miR-24-3p expression in colorectal adenoca... | Elevated expression of miR-24-3p is a potentially adverse prognostic factor in colorectal adenocarcinoma. |
{"1018": 0.09584271162748337, "2003": 0.1212492436170578, "2042": 0.14602625370025635, "2045": 0.2409527748823166, "2050": 0.22782009840011597, "2054": 0.3283478021621704, "2060": 0.08244366943836212, "2088": 0.29109421372413635, "2092": 0.20818853378295898, "2109": 0.1401015669107437, "2117": 0.2852376699447632, "2129... | 39593548 | Policy analysis is an established discipline in the industrialized world, yet its application to developing countries has been limited. The health sector in particular appears to have been neglected. This is surprising because there is a well recognized crisis in health systems, and prescriptions abound of what health ... | Reforming the health sector in developing countries: the central role of policy analysis. |
{"1011": 0.29400965571403503, "1038": 0.9333322048187256, "1042": 0.3554046154022217, "1044": 0.450652539730072, "1052": 0.8861536383628845, "1998": 0.05139094591140747, "1999": 0.04113444685935974, "2002": 0.7629209756851196, "2005": 0.08692999184131622, "2007": 0.26296505331993103, "2008": 0.045809537172317505, "2011... | 39637840 | BLM, WRN, and p53 are involved in the homologous DNA recombination pathway. The DNA structure-specific helicases, BLM and WRN, unwind Holliday junctions (HJ), an activity that could suppress inappropriate homologous recombination during DNA replication. Here, we show that purified, recombinant p53 binds to BLM and WRN ... | The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. |
{"1011": 0.2881702482700348, "2000": 0.07431721687316895, "2003": 0.0038986403960734606, "2005": 0.018384648486971855, "2015": 0.06520967930555344, "2024": 0.04394211992621422, "2025": 0.022212404757738113, "2045": 0.03360854089260101, "2057": 0.011650617234408855, "2064": 0.08692999184131622, "2071": 0.276388078927993... | 39652608 | We study recently developed nonparametric methods for estimating the number of missing studies that might exist in a meta-analysis and the effect that these studies might have had on its outcome. These are simple rank-based data augmentation techniques, which formalize the use of funnel plots. We show that they provide... | Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. |
{"1005": 0.04674193635582924, "1017": 0.22782009840011597, "1020": 0.0019512200960889459, "1041": 0.18816383183002472, "1055": 0.35813871026039124, "2007": 0.16690383851528168, "2015": 0.052318159490823746, "2018": 0.1946154683828354, "2019": 0.03266380727291107, "2029": 0.1619328260421753, "2031": 0.32129061222076416,... | 39661951 | A family with six cases of Barrett's esophagus over three generations is described. The Barrett's esophagus affected only males, and there were three associated adenocarcinomas. The mechanism of inheritance is compatible with an autosomal dominant pattern with nearly complete penetrance. Other case reports in the liter... | Familial Barrett's esophagus associated with adenocarcinoma. |
{"1039": 0.6583697199821472, "1043": 0.8740028142929077, "1999": 0.3982778787612915, "2000": 0.03266380727291107, "2004": 0.13755162060260773, "2005": 0.09938567131757736, "2007": 0.2160874605178833, "2011": 0.1718502640724182, "2012": 0.255429208278656, "2015": 0.04674193635582924, "2029": 0.025073638185858727, "2051"... | 39668245 | Conventional in vivo assays to determine the relative pathogenicity of yeast isolates rely upon the use of a range of mammalian species. The purpose of the work presented here was to investigate the possibility of using an insect (Galleria mellonella) as a model system for in vivo pathogenicity testing. The haemolymph ... | Development of an insect model for the in vivo pathogenicity testing of yeasts. |
{"1014": 0.259204238653183, "1017": 0.0354953333735466, "1020": 0.3297532796859741, "1043": 0.4002431631088257, "1054": 0.6160298585891724, "1056": 1.1300151348114014, "2000": 0.030771657824516296, "2003": 0.07431721687316895, "2004": 0.25694093108177185, "2015": 0.31560876965522766, "2019": 0.472198486328125, "2029": ... | 39728826 | An essential step in macromolecular refinement is the selection of model parameters which give as good a description of the experimental data as possible while retaining a realistic data-to-parameter ratio. This is particularly true of the choice of atomic displacement parameters, where the move from individual isotrop... | Use of TLS parameters to model anisotropic displacements in macromolecular refinement. |
{"1011": 0.23092569410800934, "1017": 0.31845372915267944, "1019": 0.10818854719400406, "1043": 0.512191891670227, "1052": 0.40806588530540466, "1054": 0.8517522215843201, "1061": 1.0101795196533203, "1997": 0.11951763927936554, "2001": 0.036437395960092545, "2005": 0.006812678650021553, "2006": 0.30989447236061096, "2... | 39729277 | To characterize the sequence features surrounding the translation initiation sites on the genome of Synechocystis sp. strain 6803, the total proteins extracted from the cell were resolved by two-dimensional electrophoresis, and the amino-terminal sequences of the relatively abundant protein spots were determined. By co... | Sequence features surrounding the translation initiation sites assigned on the genome sequence of Synechocystis sp. strain PCC6803 by amino-terminal protein sequencing. |
{"2003": 0.1212492436170578, "2019": 0.7898768186569214, "2058": 0.5685047507286072, "2076": 0.49864232540130615, "2087": 0.26446542143821716, "2100": 0.46302130818367004, "2124": 0.043007105588912964, "2129": 0.009718249551951885, "2152": 0.09317722171545029, "2170": 0.012615402229130268, "2182": 0.06703783571720123, ... | 39758684 | To reach the biological alterations that characterize cancer, the genome of tumor cells must acquire increased mutability resulting from a malfunction of a network of genome stability systems, e.g., cell cycle arrest, DNA repair, and high accuracy of DNA synthesis during DNA replication. Numeric chromosomal imbalance, ... | Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis. |
{"1011": 0.33115679025650024, "1015": 0.3519764244556427, "1017": 0.4196864068508148, "1018": 0.3910386264324188, "1038": 0.7854343056678772, "1059": 1.0695481300354004, "1996": 0.4158279001712799, "1998": 0.07250232994556427, "1999": 0.15023678541183472, "2007": 0.08692999184131622, "2008": 0.09850110858678818, "2011"... | 39763465 | We have demonstrated previously that a combination of signals from the neural tube and the floor plate/notochord complex synergistically induce the expression of myogenic bHLH genes and myogenic differentiation markers in unspecified somites. In this study we demonstrate that Sonic hedgehog (Shh), which is expressed in... | Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. |
{"1051": 0.6960725784301758, "1996": 0.07250232994556427, "2011": 0.20421554148197174, "2013": 0.13414156436920166, "2075": 0.06886265426874161, "2076": 0.07341018319129944, "2079": 0.17759032547473907, "2080": 0.31845372915267944, "2102": 0.151916041970253, "2129": 0.28155985474586487, "2139": 0.2247048318386078, "214... | 39776978 | The maintenance of adequate bone mass is dependent upon the controlled and timely removal of old, damaged bone. This complex process is performed by the highly specialized, multinucleated osteoclast. Over the past 15 years, a detailed picture has emerged describing the origins, differentiation pathways and activation s... | Advances in osteoclast biology: old findings and new insights from mouse models |
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