Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Study of the stability and the kinetics of hydrolysis on the new potential antiarrhythmic "substance H + B". | "Substance H + B", N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-N- benzylpiperidine chloride (1) is a new potential antiarrhythmic, prepared by quarternization of the local anesthetic, antiarrhythmic and antimicrobial heptacaine, N-[2-(2-heptyloxyphenylcarbamoyloxy)-ethyl]-piperidine chloride. The content of the work wa... | ['Anti-Arrhythmia Agents', 'Drug Stability', 'Hydrolysis', 'Kinetics', 'Piperidines', 'Solutions', 'Temperature'] | 7,938,147 | [['D27.505.954.411.097'], ['E05.916.330'], ['G02.380'], ['G01.374.661', 'G02.111.490'], ['D03.383.621'], ['D26.776'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Experimental hypertension and other responses to 18-hydroxy-deoxycorticosterone treatment in the rat. | Young female unilaterally nephrectomized, salt-loaded, Sprague-Dawley rats were treated with 200 microgram or 1 mg 18-hydroxy-deoxycorticosterone-21-acetate (18-OH-DOCA) in oil daily, and a group of kidney-intact animals on a normal salt intake was given 2 mg/day. The hormone was not found to increase saline consumptio... | ['18-Hydroxydesoxycorticosterone', 'Animals', 'Blood Pressure', 'Body Weight', 'Desoxycorticosterone', 'Drinking', 'Female', 'Hypertension', 'Kallikreins', 'Nephrectomy', 'Organ Size', 'Potassium', 'Rats', 'Renin', 'Sodium'] | 744,064 | [['D04.210.500.745.745.654.339.400', 'D06.472.040.585.611.400'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D04.210.500.745.745.654.339', 'D06.472.040.585.611'], ['G07.203.650.283.249', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alteration of the blood-retinal barrier and vitreous in sickle cell retinopathy. | Nineteen eyes with background sickle cell retinopathy, eleven from patients with SC disease, eight from patients with SS disease, and twelve eyes with proliferative sickle cell retinopathy were examined by direct and indirect ophthalmoscopy, slit-lamp, fluorescein angiography and vitreous fluorophotometry. Calculation ... | ['Adult', 'Anemia, Sickle Cell', 'Capillary Permeability', 'Fluorescein Angiography', 'Fluorometry', 'Humans', 'Photometry', 'Retinal Diseases', 'Retinal Vessels', 'Sickle Cell Trait', 'Vitreous Body'] | 3,721,713 | [['M01.060.116'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['G03.143.330', 'G09.330.165'], ['E01.370.370.050.350', 'E01.370.380.250'], ['E05.196.712.516.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.712'], ['C11.768'], ['A07.015.611'], ['C15.378.071.141.1... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Plasma spermidine concentrations in patients with tumours of the breast or prostate or testis. | Plasma spermidine concentrations were measured by radioimmunoassay in normal subjects and in patients with various tumours of the breast, prostate or the testis. The sensitivity of the method was 0.45 pmol spermidine/20 microliter plasma and the cross reactivity was 13% with putrescine and 2% with spermine. Plasma sper... | ['Adult', 'Aged', 'Breast Neoplasms', 'Female', 'Humans', 'Male', 'Menopause', 'Middle Aged', 'Pregnancy', 'Prostatic Hyperplasia', 'Prostatic Neoplasms', 'Spermidine', 'Testicular Neoplasms'] | 6,156,039 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.157.500', 'G08.686.841.249.500'], ['M01.060.116.630'], ['G08.686.784.769'], ['C12.294.565.500'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['D02.0... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Microinjection of Xenopus laevis oocytes as a system for studying nuclear transport of viruses. | Microinjection of Xenopus laevis oocytes is an excellent system for studying nuclear transport because of the large size of the oocyte and its high nuclear pore complex (NPC) density. In addition, the fact that Xenopus oocytes are not permissive for most mammalian viruses makes this system especially useful for studyin... | ['Active Transport, Cell Nucleus', 'Animals', 'Blotting, Western', 'Capsid', 'Immunohistochemistry', 'Microinjections', 'Microscopy, Electron', 'Models, Biological', 'Nuclear Envelope', 'Oocytes', 'Parvovirus', 'Viruses', 'Xenopus', 'Xenopus laevis'] | 20,138,149 | [['G03.143.310.100', 'G03.143.700.100'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A21.249.500.250'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', '... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of cooked functional meat enriched with omega-3 fatty acids and rosemary extract on inflammatory and oxidative status; a randomised, double-blind, crossover study. | BACKGROUND & AIM: n-3 fatty acid intake has been associated with inflammatory benefits in cardiovascular disease (CVD). Functionalising meat may be of great interest. The aim of the present study was to assess the effect of functional meat containing n-3 and rosemary extract on inflammatory and oxidative status markers... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cooking', 'Cross-Over Studies', 'Diet', 'Double-Blind Method', 'Fatty Acids, Omega-6', 'Female', 'Functional Food', 'Humans', 'Ledum', 'Lipids', 'Male', 'Meat', 'Middle Aged', 'Oxidative Stress', 'Plant Extracts', 'Young Adult'] | 25,365,012 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['J01.576.423.200.200'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G07.203.650.240'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D10.251.355.343'], ['G07.203.300.572', 'J02.500.572'], ... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Human autologous serum obtained using a completely closed bag system as a substitute for foetal calf serum in human mesenchymal stem cell cultures. | The major problem in cell therapy is the possibility of viral or bacterial infection and immune reactions. Therefore, it is expected of culture cells which are intended to be re-implanted with autologous serum rather than conventional bovine serum. Cell therapy with human mesenchymal stem cells (hMSC), differentiating ... | ['Adult', 'Cell Culture Techniques', 'Cell Differentiation', 'Cell Proliferation', 'Cell Separation', 'Culture Media', 'Environment, Controlled', 'Female', 'Humans', 'Male', 'Mesenchymal Stem Cells', 'Middle Aged', 'Serum'] | 16,616,867 | [['M01.060.116'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['D27.720.470.305', 'E07.206'], ['N06.230.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Economic evaluation of laparoscopic and open inguinal herniorrhaphies: the effect of cost-containment measures and internal hospital policy decisions on costs and charges. | BACKGROUND: Totally extraperitoneal (TEP) repairs of inguinal hernias, despite having a favorable clinical outcome are often criticized due to higher costs and charges associated with this approach. We, therefore, present a comparison of direct costs and charges between TEP and open tension-free (OPN) repairs, emphasiz... | ['Adult', 'Aged', 'Chi-Square Distribution', 'Cohort Studies', 'Cost-Benefit Analysis', 'Decision Making', 'Evaluation Studies as Topic', 'Female', 'Follow-Up Studies', 'Hernia, Inguinal', 'Hospital Charges', 'Hospital Costs', 'Humans', 'Laparoscopy', 'Laparotomy', 'Length of Stay', 'Male', 'Middle Aged', 'Pain, Postop... | 15,146,352 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N03.219.151.125'], ['F02.463.785.373'], ['E05.337', 'N05.715.360.335'], ['E05.318.372.500.750.249', 'N05.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Structure and Composition of Native Membrane Derived Polymer-Supported Lipid Bilayers. | Over the last two decades, supported lipid bilayers (SLBs) have been extensively used as model systems to study cell membrane structure and function. While SLBs have been traditionally produced from simple lipid mixtures, there has been a recent surge in compositional complexity to better mimic cellular membranes and t... | ['Animals', 'Biomimetic Materials', 'Cell Membrane', 'Glycerophospholipids', 'Lipid Bilayers', 'Microscopy, Fluorescence', 'Neutron Diffraction', 'Polyethylene Glycols', 'Spectrometry, Mass, Secondary Ion', 'Spodoptera'] | 30,350,611 | [['B01.050'], ['J01.637.087'], ['A11.284.149'], ['D10.570.755.375.760.400'], ['D10.570.510', 'J01.637.087.500.510'], ['E01.370.350.515.458', 'E05.595.458'], ['E05.196.309.555', 'E05.196.822.650', 'G01.867.650', 'G02.551'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['E05.196.566.760']... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The MTT and Crystal Violet Assays: Potential Confounders in Nanoparticle Toxicity Testing. | The toxicological effects of nanoparticles (NPs) on humans, animals, and environment are largely unknown. Assessment of NPs cytotoxicity depends on the choice of the test system. Due to NPs optical activity and absorption values, they can influence the classical cytotoxicity assay. Eight NPs were spiked in the 3-(4,5-d... | ['Biological Assay', 'Cadmium Compounds', 'Cell Line', 'Gentian Violet', 'Gold', 'Humans', 'Nanoparticles', 'Organosilicon Compounds', 'Silicon Dioxide', 'Soot', 'Sulfides', 'Tetrazolium Salts', 'Thiazoles', 'Toxicity Tests'] | 27,207,930 | [['E05.091'], ['D01.142'], ['A11.251.210'], ['D02.092.146.400'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.600'], ['D02.756'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['D20.633.937.339'], ['D01.248.497.158.874', 'D01.875.350.850'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of biostimulation and social organization on the interval from calving to resumption of ovarian cyclicity in postpartum Angus cows. | The objective was to assess the effect of biostimulation by the male presence and social organization on the interval from calving to resumption of ovarian cyclicity (ICR). Thirty Angus cows were allocated according parity into three groups (10 per group); two groups were exposed to bulls, and a third group not exposed... | ['Animals', 'Cattle', 'Corpus Luteum', 'Estrous Cycle', 'Female', 'Male', 'Postpartum Period', 'Progesterone', 'Sexual Behavior, Animal', 'Social Behavior', 'Social Dominance'] | 23,465,721 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A05.360.319.114.630.278', 'A06.300.312.497.278'], ['G08.686.195'], ['G08.686.702'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334.851.687.750'], ['F01.145.113.252.748'], ['F01.145.813'], ['F01.145.813.650']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Water balance assessment of different substrates on potash tailings piles using non-weighable lysimeters. | Water balance is an important tool to evaluate water deficit or excess in crop systems. However, few studies have evaluated the water balance of vegetation grown on the residues from potash mining because the high sodium chloride levels of the residues hinder agricultural development. Therefore, this study aims to meas... | ['Complex Mixtures', 'Germany', 'Plant Transpiration', 'Poaceae', 'Soil', 'Water'] | 28,365,548 | [['D20'], ['Z01.542.315'], ['G15.713'], ['B01.650.940.800.575.912.250.822'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Gene expression profiling of breast cancer cell lines in response to soy isoflavones using a pangenomic microarray approach. | Although the rate of breast cancer differs between women in Asian and Western countries, molecular genetics/genomics basis of this epidemiological observation remains elusive. Moreover, the intake of phytoestrogens is associated with a lower incidence of breast cancer. Genistein and daidzein are the primary soy isoflav... | ['Breast Neoplasms', 'Cell Line, Tumor', 'Cells, Cultured', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Genistein', 'Genome, Human', 'Humans', 'Isoflavones', 'Microarray Analysis', 'Molecular Sequence Data', 'Multigene Family', 'Phytoestrogens'] | 20,455,703 | [['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['E05.393.332'], ['G05.308.370'], ['D03.383.663.283.266.450.400.375', 'D03.633.100.150.266.450.400.375'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.663.283.266.450.400', 'D03.633.100.150.266.4... | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The final chapter. Sound management procedures facilitate a hospital's closure. | The closure of a healthcare institution affects employees, patients, and the community. When St. Mary's Health Center, Emporia, KS, closed in 1991, those who administered the closure followed a procedure that lessened the burden on all involved. Because of the health center's deteriorating financial picture, CSJ Health... | ['Bankruptcy', 'Catholicism', 'Community-Institutional Relations', 'Health Facility Closure', 'Hospital Bed Capacity, under 100', 'Hospitals, Religious', 'Information Services', 'Kansas', 'Patient Transfer', 'Planning Techniques', 'Vocational Guidance'] | 10,119,537 | [['N03.219.463.045'], ['K01.844.188.250'], ['N04.452.822.210'], ['N02.278.218', 'N05.300.430.390'], ['N02.278.306.472.080'], ['N02.278.421.481.600'], ['L01.453'], ['Z01.107.567.875.510.390'], ['E02.760.169.624', 'E02.760.400.630', 'N02.421.585.169.624', 'N02.421.585.400.630', 'N04.590.233.727.210.624'], ['N04.452.718']... | ['Health Care [N]', 'Humanities [K]', 'Information Science [L]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Effectiveness of photopolymerization in composite resins using a novel 445-nm diode laser in comparison to LED and halogen bulb technology. | Challenges especially in the minimal invasive restorative treatment of teeth require further developments of composite polymerization techniques. These include, among others, the securing of a complete polymerization with moderate thermal stress for the pulp. The aim of this study is to compare current light curing sou... | ['Composite Resins', 'Curing Lights, Dental', 'Halogens', 'Lasers, Semiconductor', 'Light', 'Materials Testing', 'Polymerization', 'Polymers', 'Temperature'] | 30,291,465 | [['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E06.186.104', 'E07.222.104'], ['D01.268.380'], ['E07.632.490.480', 'E07.710.520.480'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.570'], ['G02.750'], [... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Summertime conditions of a muddy estuarine environment: the EsCoSed project contribution. | As part of the Estuarine Cohesive Sediments (EsCoSed) project, a field experiment was performed in a highly engineered environment, acting as a natural laboratory, to study the physico-chemical properties of estuarine sediments and the associated hydro-morphodynamics during different seasons. The present contribution f... | ['Environmental Monitoring', 'Estuaries', 'Geologic Sediments', 'Italy', 'Rivers', 'Seasons', 'Water', 'Water Movements', 'Water Pollutants, Chemical'] | 26,442,485 | [['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.625.540'], ['G01.311.330', 'G16.500.320'], ['Z01.542.489'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], ['G16.50... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[High-dose thiotepa chemotherapy in children]. | High-dose thiotepa (800-900 mg/m2) polychemotherapy following combined treatment resulted in high toxicity and lethality. 600 mg/m2 proved optimal for double-conditioning regimens since it exerted antitumor effect without causing fatal complications. | ['Adolescent', 'Antineoplastic Agents, Alkylating', 'Antineoplastic Combined Chemotherapy Protocols', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Kidney Neoplasms', 'Male', 'Survival Analysis', 'Thiotepa', 'Treatment Outcome', 'Wilms Tumor'] | 11,147,412 | [['M01.060.057'], ['D27.505.519.124.035', 'D27.505.954.248.150', 'D27.888.569.035.035'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Management of stroke as described by Ibn Sina (Avicenna) in the Canon of Medicine. | Stroke or cerebrovascular accident (CVA) is caused by a disturbance of the blood supply to the brain and an accruing loss of brain function. The first recorded observations were in 2455 BC and it has been studied intensely by ancient physicians throughout history. In the early medieval period, Ibn Sina (980-1025 AD) ca... | ['Disease Management', 'History, Medieval', 'Humans', 'Medicine, Arabic', 'Reference Books, Medical', 'Stroke'] | 24,063,916 | [['N04.590.607'], ['K01.400.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.488.510', 'I01.076.201.450.654.510'], ['L01.178.682.192.836.842'], ['C10.228.140.300.775', 'C14.907.253.855']] | ['Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Comprehensive DNA methylation analysis of tissue of origin of plasma cell-free DNA by methylated CpG tandem amplification and sequencing (MCTA-Seq). | BACKGROUND: Comprehensive analysis of the tissue of origin of plasma cell-free DNA (cfDNA) remains insufficient. A genome-scale DNA methylation method for this analysis is of both biological and clinical interest.METHODS: We used the methylated CpG tandem amplification and sequencing (MCTA-Seq), which is a genome-scale... | ['Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Case-Control Studies', 'Cell-Free Nucleic Acids', 'Cholelithiasis', 'CpG Islands', 'DNA Methylation', 'Female', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Liver', 'Liver Cirrhosis', 'Liver Neoplasms', 'Male', 'Organ Specificity', 'Pancreas', 'Pancreatitis', '... | 31,234,922 | [['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D13.444.154'], ['C06.130.409'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G02.111.035.538.161', ... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Paradiplozoon yunnanensis n. sp. (Monogenea, Diplozoidae) from Sikukia gudgeri (Cyprinidae, Barbinae) in southwest China. | Paradiplozoon yunnanensis n. sp. (Monogenea, Diplozoidae) is described from the gills of Sikukia gudgeri Smith, 1931 (Cyprinidae) collected from Jinghong Basin, a tributary of the international Lancang-Mekong River. This is the first diplozoid species from S. gudgeri and its description increases the number of Paradipl... | ['Animals', 'China', 'Cyprinidae', 'DNA, Helminth', 'Fish Diseases', 'Gills', 'Phylogeny', 'RNA, Ribosomal', 'Rivers', 'Trematoda', 'Trematode Infections'] | 30,192,224 | [['B01.050'], ['Z01.252.474.164'], ['B01.050.150.900.493.200.244'], ['D13.444.308.315'], ['C22.362'], ['A13.421'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['B01.050.500.500.736.715'], ['C01.610.335.865']] | ['Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
The expression and significance of five types of miRNAs in breast cancer. | BACKGROUND: This study aimed to investigate the expression and significance of 5 types of miRNAs in breast cancer to provide a theoretical and practical foundation for using these miRNAs in the diagnosis and treatment of breast cancer, thereby improving medical services.MATERIAL/METHODS: Stem-loop real-time RT-PCR was ... | ['Adult', 'Antigens, Neoplasm', 'Breast Neoplasms', 'DNA Topoisomerases, Type II', 'DNA-Binding Proteins', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'In Situ Hybridization, Fluorescence', 'MicroRNAs', 'Middle Aged', 'Receptor, ErbB-2'] | 25,047,098 | [['M01.060.116'], ['D23.050.285'], ['C04.588.180', 'C17.800.090.500'], ['D08.811.399.403.741'], ['D12.776.260'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.350', 'E05.200.750.600.670.325.350', 'E05.393... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Further studies on rapid dilution and warming of boar semen. | Studies have been carried out to investigate factors related to the induction of warm shock in boar spermatozoa. Rapid dilution per se caused visible damage to acrosomes when the sample contained 7.5% or more glycerol. This dilution effect was greater at lower temperatures. Acrosomal damage was greatly reduced by raisi... | ['Acrosome', 'Animals', 'Butylated Hydroxytoluene', 'Cryoprotective Agents', 'Freezing', 'Hot Temperature', 'Male', 'Semen Preservation', 'Spermatozoa', 'Swine', 'Time Factors'] | 3,361,486 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['B01.050'], ['D02.455.426.559.389.657.239.216'], ['D27.505.696.706.320', 'D27.720.799.180'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', '... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Mating activity of male SHR rats infected with sialodacryoadenitis virus]. | The male SHR rats infected with sialodacryoadenitis (SDA) virus did not show any abnormal mating activity. However, high mortality was seen in embryos of diseased dams after cage-mating with infected males on Day 4 to Day 11 postinoculation. | ['Animals', 'Coronaviridae Infections', 'Female', 'Fetal Death', 'Male', 'Pregnancy', 'Rats', 'Rats, Inbred SHR', 'Reproduction', 'Sexual Behavior, Animal', 'Time Factors'] | 8,390,940 | [['B01.050'], ['C01.925.782.600.550'], ['C13.703.223', 'C23.550.260.585'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.300', 'B01.050.150.900.649.313.992.635.505.700.400.300'], ['G08.686.784'], ['F01.145.113.252.748'], ['G01.910.857']] | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanism of allergic cross-reactions. V. High incidence of unanticipated cross-stimulation by natural allergens of rat basophilic leukemia cells sensitized with monoclonal IgE antibodies. | The incidence of cross-stimulations by natural allergens was investigated using RBL-2H3 cells sensitized with five different mouse monoclonal anti-DNP IgEs and four mercury-induced rat monoclonal IgEs. Cells sensitized with 3 of the 5 monoclonal anti-DNP IgEs (clones SPE-7, SRT-1, LB4) responded by serotonin release up... | ['Allergens', 'Animals', 'Antibodies, Monoclonal', 'Antigens, Dermatophagoides', 'Cell Degranulation', 'Cross Reactions', 'Glycoproteins', 'Immunoglobulin E', 'Leukemia, Basophilic, Acute', 'Mast Cells', 'Mites', 'Rats', 'Serotonin'] | 7,549,509 | [['D23.050.063'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.181'], ['G04.468.160'], ['G12.122.281'], ['D09.400.430', 'D12.776.395'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312'], ['C0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prioritizing comparative-effectiveness research topics via stakeholder involvement: an application in COPD. | A major priority for funding agencies and researchers involved in comparative-effectiveness research (CER) is to ensure that research questions will produce findings that are relevant and feasible to implement. In this article, we describe a process for involving experts and stakeholders in identifying and prioritizing... | ['Comparative Effectiveness Research', 'Decision Making', 'Humans', 'Policy Making', 'Pulmonary Disease, Chronic Obstructive', 'Research Support as Topic', 'United States'] | 22,048,220 | [['H01.770.644.145.360.500', 'N05.425.157'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.742'], ['C08.381.495.389'], ['N03.219.483.645'], ['Z01.107.567.875']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Health-related and condition-specific quality of life in episodic cluster headache. | Health-related quality of life was studied in 35 episodic cluster headache (CH) patients during and after the cluster period, using a generic (SF-36) and a headache-specific (MSQ2.1) instrument. The results were compared with those of age- and sex-matched migraineurs (n = 53) and healthy persons (n = 62). During the cl... | ['Adult', 'Aged', 'Analysis of Variance', 'Cluster Headache', 'Female', 'Health Status', 'Health Surveys', 'Humans', 'Male', 'Middle Aged', 'Quality of Life', 'Statistics, Nonparametric'] | 15,009,012 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C10.228.140.546.399.937.500'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Evaluation of risk factors that contribute to high prevalence of premature atherosclerosis in Chinese premenopausal systemic lupus erythematosus patients. | OBJECTIVE: To evaluate the prevalence of atherosclerosis in Chinese premenopausal women with systemic lupus erythematosus (SLE) and study possible associations between traditional and nontraditional risk factors with premature atherosclerosis.METHODS: We evaluated 111 premenopausal women with SLE and 40 healthy control... | ['Adolescent', 'Adult', 'Age Factors', 'Atherosclerosis', 'Body Mass Index', 'Carotid Artery Diseases', 'Case-Control Studies', 'China', 'Female', 'Humans', 'Hypertension', 'Lupus Erythematosus, Systemic', 'Middle Aged', 'Premenopause', 'Risk Factors', 'Severity of Illness Index', 'Tunica Intima', 'Tunica Media', 'Vaso... | 19,300,290 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C14.907.137.126.307'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C10.228.140.300.200', 'C14.907.253.123'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
To drain or not to drain - management of pediatric deep neck abscesses: a case-control study. | UNLABELLED: Optimal management of deep neck abscesses has been the subject of debate for more than a century: surgical drainage has been the mainstay of treatment, but recently many centres have reported successful non-operative management in selected cases.OBJECTIVES: Our objective was to review the management of deep... | ['Abscess', 'Adolescent', 'Anti-Bacterial Agents', 'Child', 'Child, Preschool', 'Cohort Studies', 'Drainage', 'Drug Therapy, Combination', 'Female', 'Follow-Up Studies', 'Humans', 'Infusions, Intravenous', 'Logistic Models', 'Male', 'Multivariate Analysis', 'Neck', 'Pharyngeal Diseases', 'Reference Values', 'Retrophary... | 23,089,190 | [['C01.830.025', 'C23.550.470.756.100'], ['M01.060.057'], ['D27.505.954.122.085'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.309', 'E04.237'], ['E02.319.310'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of nitroglycerin at therapeutic doses on platelet aggregation in unstable angina pectoris and acute myocardial infarction. | The platelet aggregation response to adenosine diphosphate (ADP) and to thrombin was quantified in 10 patients, 5 with unstable angina pectoris and 5 with acute myocardial infarction, before, during and after a 45-minute infusion of nitroglycerin. An impedance aggregometer allowing rapid bedside studies in whole blood ... | ['Adenosine Diphosphate', 'Angina Pectoris', 'Angina, Unstable', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Nitroglycerin', 'Platelet Aggregation', 'Platelet Aggregation Inhibitors', 'Platelet Function Tests', 'Thrombin', 'Time Factors'] | 2,119,139 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['C14.280.647.187.150', 'C14.907.585.187.150', 'C23.888.592.612.233.500.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Independent coding across spatial scales in moving fractal images.. | We compared observers' ability to discriminate the direction of apparent motion using images which varied in their spatial characteristic; white or flat spectrum noise, and 1/f noise which has an amplitude spectrum characteristic of natural scenes. The upper spatial limit for discrimination (dmax) was measured using a ... | ['Contrast Sensitivity', 'Discrimination, Psychological', 'Humans', 'Male', 'Motion Perception', 'Optical Illusions', 'Pattern Recognition, Visual', 'Psychophysics'] | 9,274,773 | [['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.940.500'], ['F02.463.593.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.932.567'], ['F02.463.593.446.659'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E01.370.685', 'F04.096.753']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of oatp1. | Recent studies implicate a role in hepatocyte organic anion transport of a plasma membrane protein that has been termed oatp1 (organic anion transport protein 1). Little is known regarding mechanisms by which its transport activity is modulated in vivo. In previous studies (Campbell, C. G., Spray, D. C., and Wolkoff, A... | ['Adenosine Triphosphate', 'Animals', 'Anion Transport Proteins', 'Biological Transport', 'Carrier Proteins', 'Cells, Cultured', 'Enzyme Inhibitors', 'Kinetics', 'Liver', 'Male', 'Marine Toxins', 'Okadaic Acid', 'Oxazoles', 'Phosphopeptides', 'Phosphorylation', 'Phosphoserine', 'Protein Tyrosine Phosphatases', 'Rats', ... | 10,625,701 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D12.776.157.530.450.074', 'D12.776.543.585.450.074'], ['G03.143'], ['D12.776.157'], ['A11.251'], ['D27.505.519.389'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['D23.946.580'], ['D02.355.291.705', 'D23.946.580.710'], ['D03... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intrapericardial bevacizumab safely and effectively treats malignant pericardial effusion in advanced cancer patients. | We evaluated the safety and efficacy of intrapericardial bevacizumab (BEV) for treating symptomatic malignant pericardiac effusion (MPCE) in seven advanced cancer patients. All patients had previously undergone multiple lines of systemic therapy. Each patient received paracentesis and intrapericardial infusions of 100 ... | ['Adult', 'Aged', 'Antineoplastic Agents, Immunological', 'Bevacizumab', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Pericardial Effusion', 'Retrospective Studies', 'Young Adult'] | 27,203,219 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248.384'], ['D12.776.124.486.485.114.224.060.375', 'D12.776.124.790.651.114.224.060.438', 'D12.776.377.715.548.114.224.200.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['C14.280.695'], ['E05.318.372.500.500.500', 'E05.318.372.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Evaluation of the performances of the "MUSE AUTO CD4/CD4%" flow cytometer vs "GUAVA AUTO CD4/CD4%" flow cytometer for measuring the rate of CD4 lymphocytes in patients infected with HIV in Cameroon]. | Introduction: This study aimed to evaluate the performances of the MUSE® flow cytometer compared with the reference GUAVA® flow cytometer.Methods: We conducted an experimental study on HIV-infected patient samples. Venous blood samples, collected in a K3 EDTA tube, were analyzed within 24-48 hours by MUSE® and GUAVA® c... | ['Adult', 'CD4 Lymphocyte Count', 'CD4-Positive T-Lymphocytes', 'Cameroon', 'Female', 'Flow Cytometry', 'HIV Infections', 'Humans', 'Linear Models', 'Male', 'Middle Aged'] | 31,068,996 | [['M01.060.116'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Thoracoscopy for the treatment of spontaneous pneumothorax]. | Video-assisted thoracoscopy has used for lots of thoracic disorders. Spontaneous pneumothorax may be ideally suited for thoracoscopic management. Stapling of apical blebs and pleurodesis can now be performed thoracoscopically. We compared our results with thoracoscopic management of spontaneous pneumothorax in 12 patie... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pleurodesis', 'Pneumothorax', 'Thoracoscopy', 'Video Recording'] | 7,750,414 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.319.694'], ['C08.528.778'], ['E01.370.388.250.840', 'E04.502.250.840', 'E04.928.752'], ['L01.280.960']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Nasal receptors responding to noxious chemical irritants. | This study was performed to investigate the chemoreception of trigeminal afferents in the nose. Single unit activity was recorded from the anterior ethmoidal nerve in the anesthetized guinea pig breathing through a tracheostomy during nasal instillation of capsaicin (0.3 mM), nicotine (6 mM) and ammonia (1.5 M) solutio... | ['Ammonia', 'Animals', 'Capsaicin', 'Chemoreceptor Cells', 'Female', 'Guinea Pigs', 'Male', 'Nasal Cavity', 'Nerve Fibers', 'Nicotine', 'Stimulation, Chemical'] | 8,023,019 | [['D01.362.075', 'D01.625.050'], ['B01.050'], ['D02.065.690.500', 'D02.455.326.271.690.222', 'D02.455.426.559.389.657.166.099', 'D03.132.760.200', 'D10.251.355.325.190'], ['A08.675.650.915.500', 'A08.800.950.500', 'A11.671.650.915.500'], ['B01.050.150.900.649.313.992.550'], ['A04.531.449'], ['A08.675.542', 'A11.671.501... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes. | The distribution of phospholipids across erythrocyte membrane bilayer is asymmetrical. The present study reports the effect of malonyldialdehyde (MDA), a product of fatty acid peroxidation, on the organization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in human erythrocytes using a nonpermeable bee ve... | ['Antioxidants', 'Erythrocyte Membrane', 'Humans', 'Hydrogen Peroxide', 'Lipid Bilayers', 'Malonates', 'Malondialdehyde', 'Membrane Lipids', 'Phosphatidylethanolamines', 'Phosphatidylserines', 'Phospholipases A', 'Phospholipases A2'] | 6,706,963 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D10.570.510', 'J01.637.087.500.510'], ['D02.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Extraarticular pigmented villonodular synovitis of the hip. | Pigmented villonodular synovitis of any joint in the extraarticular region is very rare. Its clinical and radiological differential diagnosis is difficult due to exhibiting findings of any soft tissue tumor. Here we report an extrarticular pigmented villonodular synovitis case of the hip of a five-year-old boy, with it... | ['Hip', 'Hip Joint', 'Humans', 'Infant', 'Magnetic Resonance Imaging', 'Male', 'Prognosis', 'Synovitis, Pigmented Villonodular'] | 15,641,275 | [['A01.378.610.400'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.350.825.500'], ['E01.789'], ['C04.557.450.565.380.690.500', 'C05.550.870.445.500', 'C05.651.869.762.500']] | ['Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A general and efficient synthesis of pyridin-2-yl C-ribonucleosides bearing diverse alkyl, aryl, amino, and carbamoyl groups in position 6. | An efficient and practical methodology of preparation of 6-substituted pyridin-2-yl C-ribonucleosides was developed. A one-pot two-step addition of 2-lithio-6-bromopyridine to TBS-protected ribonolactone followed by acetylation gave 1beta-(6-bromopyridin-2-yl)-1-O-acetyl-2,3,5-tri-O-(tert-butyldimethylsilyl)-D-ribofura... | ['Alkanes', 'Carbamates', 'Catalysis', 'Chromatography, High Pressure Liquid', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Monosaccharides', 'Palladium', 'Ribonucleotides', 'Structure-Activity Relationship'] | 20,000,693 | [['D02.455.326.146'], ['D02.241.081.251'], ['G02.130'], ['E05.196.181.400.300'], ['E05.196.867.519'], ['G02.111.570', 'G02.466'], ['D09.947.875'], ['D01.268.556.680', 'D01.268.956.718', 'D01.552.544.680'], ['D13.695.827'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nursing externship: a collaborative endeavor between nursing education and nursing administration. | This article provides an excellent description of an 8-week summer externship program for nursing students. | ['Education, Nursing', 'Faculty, Nursing', 'Humans', 'Interprofessional Relations', 'Nurse Administrators', 'Preceptorship'] | 14,639,115 | [['I02.358.462'], ['M01.526.485.390', 'M01.526.702.250.473', 'N02.360.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['M01.526.070.670', 'M01.526.485.650.580', 'N02.360.650.580'], ['I02.358.968']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Cell-mediated immunity and lymphocyte populations in experimental Argentine hemorrhagic fever (Jun?n Virus). | Guinea pigs infected with the XJ prototype strain of Jun?n virus reproduce the main features of Argentine hemorrhagic fever, showing hemorrhages, leukothrombocytopenia, and focal lymphoid tissue necrosis. Viral lymphotropism is shown by the presence of viral antigens, severe cytopathic effect, and high virus titers in ... | ['Animals', 'Arenaviruses, New World', 'B-Lymphocytes', 'Guinea Pigs', 'Hemorrhagic Fever, American', 'Hypersensitivity, Delayed', 'Leukocyte Count', 'Lymph Nodes', 'Rosette Formation', 'Spleen', 'T-Lymphocytes', 'Tuberculin Test'] | 6,273,314 | [['B01.050'], ['B04.820.480.500.070.095'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['B01.050.150.900.649.313.992.550'], ['C01.925.782.082.440', 'C01.925.782.417.400'], ['C20.543.418'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.5... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular variation in the major outer membrane protein P5 gene of nonencapsulated Haemophilus influenzae during chronic infections. | During the course of persistent infections by nonencapsulated Haemophilus influenzae in patients with chronic bronchitis, the major outer membrane protein (MOMP) P5 varies in molecular weight. The nature of this variability was determined by DNA sequence analysis of the P5 gene from five different H. influenzae strains... | ['Amino Acid Sequence', 'Bacterial Outer Membrane Proteins', 'Base Sequence', 'Chronic Disease', 'DNA, Bacterial', 'Haemophilus Infections', 'Haemophilus influenzae', 'Humans', 'Molecular Sequence Data', 'Point Mutation'] | 9,119,473 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097.120', 'D12.776.543.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C23.550.291.500'], ['D13.444.308.212'], ['C01.150.252.400.700.433'], ['B03.440.450.600.450.330', 'B03.660.250.550.290.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Genotyping genome-edited mutations in plants using CRISPR ribonucleoprotein complexes. | Despite the great achievements in genome editing, accurately detecting mutations induced by sequence-specific nucleases is still a challenge in plants, especially in polyploidy plants. An efficient detection method is particularly vital when the mutation frequency is low or when a large population needs to be screened.... | ['CRISPR-Associated Protein 9', 'CRISPR-Cas Systems', 'DNA, Plant', 'Gene Editing', 'Genotyping Techniques', 'Mutation', 'Polymerase Chain Reaction', 'Ribonucleoproteins', 'Sequence Analysis, DNA', 'Triticum'] | 29,723,918 | [['D08.811.277.352.355.325.150', 'D12.776.097.219', 'D12.776.212.500'], ['G05.308.203.374.394'], ['D13.444.308.435'], ['E05.393.420.270'], ['E05.393.442'], ['G05.365.590'], ['E05.393.620.500'], ['D12.776.157.725.500', 'D12.776.664.962.500'], ['E05.393.760.700'], ['B01.650.940.800.575.912.250.822.918']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Studies on isolation and identification of flavonoids in herbs of Agrimonia pilosa]. | OBJECTIVE: To study the chemical constituents in Agrimonia pilosa.METHOD: The compounds were isolated and purified by various column chromatographic methods and elucidated on the basis of chemical and spectroscopic evidences.RESULT: Nine flavonoids were obtained and identified as tiliroside (1), kaempferol 3-O-alpha-L-... | ['Agrimonia', 'Drugs, Chinese Herbal', 'Flavonoids'] | 19,294,852 | [['B01.650.940.800.575.912.250.859.937.500.033'], ['D20.215.784.500.350', 'D26.335'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450']] | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reversible switching of the sol-gel transition with ultrasound in rhodium(I) and iridium(I) coordination networks. | Reversible coordination networks were prepared by combining diphenylphosphinite telechelic polytetrahydrofuran (2) with [RhCl(COD)]2 or [IrCl(COD)]2 in chloroform. Both systems resulted in stable gels at concentrations above 50 and 30 g/L for the rhodium(I) and iridium(I) networks, respectively. The rheological propert... | ['Furans', 'Gels', 'Iridium', 'Ligands', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Organometallic Compounds', 'Phase Transition', 'Phosphorus Isotopes', 'Reference Standards', 'Rheology', 'Rhodium'] | 17,269,773 | [['D03.383.312'], ['D20.280.320', 'D26.255.165.320'], ['D01.268.556.401', 'D01.268.956.280', 'D01.552.544.401'], ['D27.720.470.480'], ['E05.196.867.519'], ['G02.111.570', 'G02.466'], ['D02.691'], ['G01.645', 'G02.734'], ['D01.268.666.500', 'D01.496.669'], ['E05.978.808'], ['E05.830', 'H01.671.808'], ['D01.268.556.793',... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Characteristics of Staphylococcus aureus infections, Chicago Pediatric Hospital. | Invasive and skin community-associated (CA)-methicillin-resistant Staphylococcus aureus isolates from children were matched with invasive CA-methicillin-sensitive S. aureus strains during 2000-2004. Isolates were analyzed for presence of Panton-Valentine leukocidin. A USA400 lineage clone (n = 6) and the predominant US... | ['Adolescent', 'Chicago', 'Child', 'Child, Preschool', 'Community-Acquired Infections', 'Hospitals, Pediatric', 'Humans', 'Infant', 'Methicillin Resistance', 'Staphylococcal Infections', 'Staphylococcus aureus'] | 17,479,900 | [['M01.060.057'], ['Z01.107.567.875.350.350.200', 'Z01.107.567.875.510.350.200', 'Z01.433.305'], ['M01.060.406'], ['M01.060.406.448'], ['C01.234'], ['N02.278.421.556.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G06.099.225.500.600.525', 'G06.225.347.500.600.525', 'G07.690.773.984.269.347.5... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Evaluation of the efficacy of amplitude-integrated electroencephalography in the screening of newborns with metabolic disorder admitted to the NICU. | BACKGROUND: Neonate patients with metabolic disorder show encephalopathy and seizures that may lead to morbidity and mortality. Thus rapid detection and treatment of these patients is necessary. Although Amplitude-integrated electroencephalography (aEEG) has been used for more than a decade in the evaluation of infants... | ['Early Diagnosis', 'Electroencephalography', 'Female', 'Humans', 'Infant, Newborn', 'Intensive Care Units, Neonatal', 'Male', 'Metabolic Diseases', 'Muscle Hypotonia', 'Pilot Projects', 'Seizures', 'Surveys and Questionnaires'] | 30,236,069 | [['E01.390'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N02.278.388.493.390.380'], ['C18.452'], ['C10.597.613.575', 'C23.888.592.608.575'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['C10.597.742', 'C23.888.592... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of various sympathomimetics on the regional circulations in hyperdynamic sepsis. | Because sepsis is characterized by a depression in vascular reactivity, we hypothesized that changes in organ blood flows (Q) would differ between the nonseptic and septic state during the infusion of sympathomimetics. Therefore we examined the (sepsis x organ Q) interaction during the infusion of five sympathomimetics... | ['Animals', 'Biological Availability', 'Blood Circulation', 'Cardiac Output', 'Cecum', 'Hemodynamics', 'Infections', 'Ligation', 'Male', 'Oxygen', 'Punctures', 'Regional Blood Flow', 'Sympathomimetics'] | 1,519,172 | [['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['G09.330.100'], ['E01.370.370.380.150', 'G09.330.380.124'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['G09.330.380'], ['C01'], ['E04.426'], ['D01.268.185.550', 'D01.362.670'], ['E02.800', 'E04.665'], ['G09.330.100.780'], ['D27.505.696.663.050.870']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differentiation of Schwann‑like cells from human umbilical cord blood mesenchymal stem cells in vitro. | The use of artificial nerves for the repair of peripheral nerve defects is restricted by the limited sources of Schwann cells (SCs). Human mesenchymal stem cell (MSC)‑derived Schwann‑like cells are considered an alternative and desirable cell source. The aim of the present study was to establish a method of inducing di... | ['Adipocytes', 'Cell Differentiation', 'Cells, Cultured', 'Fetal Blood', 'Glial Fibrillary Acidic Protein', 'Humans', 'Mesenchymal Stem Cells', 'Osteocytes', 'Osteogenesis', 'S100 Calcium Binding Protein beta Subunit', 'Schwann Cells'] | 25,369,806 | [['A11.329.114'], ['G04.152'], ['A11.251'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['A11.329.629.500'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'],... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity are mediated by TRPM2 in rat primary striatal cultures. | Amyloid beta-peptide (Abeta) is the main component of senile plaques which characterize Alzheimer's disease and may induce neuronal death through mechanisms which include oxidative stress. To date, the signalling pathways linking oxidant stress, a component of several neurodegenerative diseases, to cell death in the CN... | ['Alzheimer Disease', 'Amyloid beta-Peptides', 'Animals', 'Calcium', 'Cell Death', 'Cells, Cultured', 'Clusterin', 'Corpus Striatum', 'Hydrogen Peroxide', 'Neurons', 'Oxidants', 'Oxidative Stress', 'Peptide Fragments', 'Rats', 'Rats, Sprague-Dawley'] | 16,104,849 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.146'], ['A11.251'], ['D12.776.395.207', 'D12.776.580.215'], ['A08.186.211.200.885.287.249.487'], ['D01.248.497.158.... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB. | Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma, which shows high aggressiveness and lacks biomarkers. RhoB acts as a tumor suppressor that inhibits the progression of ccRCC. In the present study, we examined the effects of oncogenic microRNAs, miR-19a and miR-19b, on RhoB exp... | ["3' Untranslated Regions", 'Apoptosis', 'Carcinoma, Renal Cell', 'Cell Line, Tumor', 'Cell Proliferation', 'Gene Knockdown Techniques', 'Humans', 'Kidney Neoplasms', 'MicroRNAs', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Metastasis', 'Real-Time Polymerase Chain Reaction', 'rhoB GTP-Binding Protein'] | 29,474,434 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['G04.146.954.035'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['A11.251.210.190', ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Deep learning-based color holographic microscopy. | We report a framework based on a generative adversarial network that performs high-fidelity color image reconstruction using a single hologram of a sample that is illuminated simultaneously by light at three different wavelengths. The trained network learns to eliminate missing-phase-related artifacts, and generates an... | ['Color', 'Deep Learning', 'Holography', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Microscopy', 'Prostate'] | 31,309,728 | [['G01.590.540.199'], ['G17.035.250.500.250', 'G17.485.500', 'L01.224.050.375.530.250', 'L01.224.050.375.605.500'], ['E01.370.350.400.500', 'E01.370.350.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['A05.360.444.575', 'A10.336.707']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of L-proline on swimming parameters of Daphnia magna subjected to heat stress. | L-proline (L-PROL) is an essential amino acid, a constituent of many proteins and the osmoprotective molecule produced and accumulated in higher plants and some freshwater microalgae in response to various environmental stressors. Knowledge on thermoprotective effects of this amino acid on freshwater invertebrates is v... | ['Animals', 'Behavior, Animal', 'Daphnia', 'Female', 'Heat-Shock Response', 'Proline', 'Swimming'] | 31,466,748 | [['B01.050'], ['F01.145.113'], ['B01.050.500.131.365.150.200'], ['G07.775.500'], ['D12.125.072.401.623'], ['G11.427.410.568.800', 'G11.427.410.698.277.875', 'I03.350.875', 'I03.450.642.845.945.500']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Regulatory mechanism for expression of IL1B receptors in the uterine endometrium and effects of IL1B on prostaglandin synthetic enzymes during the implantation period in pigs. | During the implantation period, the porcine conceptus secretes interleukin-1beta (IL1B) that may be involved in the establishment of pregnancy in pigs. However, the regulatory mechanism for IL1B receptor expression and the function of IL1B in the uterine endometrium are not well elucidated. In this study, we determined... | ['Animals', 'Embryo Implantation', 'Endometrium', 'Estradiol', 'Estrous Cycle', 'Female', 'Interferon-gamma', 'Interleukin-1 Receptor Accessory Protein', 'Interleukin-1beta', 'Pregnancy', 'Progesterone', 'Prostaglandins', 'RNA, Messenger', 'Receptors, Interleukin-1 Type I', 'Swine'] | 22,572,995 | [['B01.050'], ['G08.686.784.170.104.500'], ['A05.360.319.679.490'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G08.686.195'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['D12.776.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of three corticotropin-releasing factor receptors in catfish: a novel third receptor is predominantly expressed in pituitary and urophysis. | The present study reports the isolation of three complementary DNA (cDNA) clones encoding distinct subtypes of CRF receptors from the diploid catfish (cf) species, Ameiurus nebulosus. The first clone encodes a 446-amino acid protein (cfCRF-R1) that is highly homologous to mouse (m) CRF-R1 (93% identical). The cfCRF-R1 ... | ['Amino Acid Sequence', 'Animals', 'Brain', 'COS Cells', 'Catfishes', 'Chlorocebus aethiops', 'Cloning, Molecular', 'Conserved Sequence', 'Glycosylation', 'Humans', 'Mice', 'Molecular Sequence Data', 'Neurosecretory Systems', 'Organ Specificity', 'Phylogeny', 'Pituitary Gland', 'Receptors, Corticotropin-Releasing Hormo... | 11,145,609 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A08.186.211'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.493.080'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E05.393.220'], ['G02.111.570.580'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['B01.050.150.900.649.313.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Isolation and function of human and pig islets. | This report confirms reproducible methods to isolate and assess viability and function of pig and human islets. We processed 10 pig and five human pancreata. The pancreata were digested by a modification of Ricordi's automated method for islet isolation. The number of islet equivalents (150 microns diameter islets) was... | ['Adult', 'Animals', 'Humans', 'In Vitro Techniques', 'Islets of Langerhans', 'Male', 'Middle Aged', 'Swine'] | 8,190,716 | [['M01.060.116'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A03.734.414', 'A06.300.414'], ['M01.060.116.630'], ['B01.050.150.900.649.313.500.880']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Basic studies in intra-arterial chemotherapy with degradable starch microspheres (DSM) on human gastric cancer xenografts in nude rats]. | Enhancement of the antitumor effect of adriamycin (ADR) was investigated by using degradable starch microspheres (DSM) and pharmacokinetics of ADR in combination with DSM. An intra-arterial chemotherapy model of the nude rats transplanted of human cancer xenografts (H-154 gastric cancer) in the lower limbs was used for... | ['Animals', 'Doxorubicin', 'Embolization, Therapeutic', 'Female', 'Humans', 'Infusions, Intra-Arterial', 'Male', 'Microspheres', 'Neoplasm Transplantation', 'Rats', 'Rats, Nude', 'Starch', 'Stomach Neoplasms', 'Transplantation, Heterologous'] | 3,415,262 | [['B01.050'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E02.520.360', 'E02.926.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510.520'], ['E07.565'], ['E05.624'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of the performance of submerged membrane bioreactor (SMBR) and submerged membrane adsorption bioreactor (SMABR). | This study focuses on comparing the performance of submerged membrane bioreactor (SMBR) and submerged membrane adsorption bioreactor (SMABR) over a period of 20 days at a hydraulic retention time (HRT) of 3.1h. The effects of PAC on critical flux and membrane fouling were also investigated. The SMABR exhibited better r... | ['Adsorption', 'Bioreactors', 'Enterobacteriaceae', 'Oxygen', 'Waste Disposal, Fluid'] | 17,499,503 | [['G01.030', 'G02.020'], ['E07.115', 'J01.897.120.115'], ['B03.440.450.425', 'B03.660.250.150'], ['D01.268.185.550', 'D01.362.670'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Schisandrin B inhibits TGF-â1-induced epithelial-mesenchymal transition in human A549 cells through epigenetic silencing of ZEB1. | Purpose/Aim: More and more evidences suggest that airway remodeling of fibrotic lung diseases may be associated with epithelial-mesenchymal transition (EMT) of human A549 cells induced by transforming growth factor (TGF)-â1. Schisandrin B (Sch B) is the highest content of dibenzocyclooctadiene lignans in Schisandra chi... | ['A549 Cells', 'Antineoplastic Agents', 'Cyclooctanes', 'Drug Evaluation, Preclinical', 'Epigenesis, Genetic', 'Epithelial-Mesenchymal Transition', 'Humans', 'Lignans', 'Phytotherapy', 'Polycyclic Compounds', 'Pulmonary Fibrosis', 'Schisandra', 'Transforming Growth Factor beta1', 'Zinc Finger E-box-Binding Homeobox 1'] | 31,268,360 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['D27.505.954.248'], ['D02.455.426.392.368.408'], ['E05.290.750', 'E05.337.550'], ['G05.308.203'], ['G04.356.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.426.559.389.140.450'], ['E02.190.755'], ['D04'], ['C08.381.765'], ['B01.650.940.8... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A prospective study of treatment of carbapenem-resistant Enterobacteriaceae infections and risk factors associated with outcome. | BACKGROUND: To describe the clinical and microbiological data of carbapenem-resistant Enterobacteriaceae (CRE) infections, the treatment used, hospital- and infection-related mortality, and risk factors for death.METHODS: A prospective cohort conducted from March 2011 to December 2012. Clinical, demographic, and microb... | ['Adult', 'Age Factors', 'Aged', 'Anti-Bacterial Agents', 'Bacterial Proteins', 'Carbapenems', 'Cohort Studies', 'Colistin', 'Drug Resistance, Bacterial', 'Electrophoresis, Gel, Pulsed-Field', 'Enterobacteriaceae', 'Enterobacteriaceae Infections', 'Female', 'Hospital Mortality', 'Humans', 'Kidney Failure, Chronic', 'Ma... | 27,809,803 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['D12.776.097'], ['D02.065.589.099.124', 'D03.633.100.300.124'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D04.345.566.780.110', 'D10.477.750.110', 'D12.644.050.600.110', 'D12.6... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Developmental toxicity study of inhaled acrylic acid in New Zealand White rabbits. | In range-finding and definitive developmental toxicity studies, timed pregnant New Zealand White rabbits were exposed to acrylic acid (CAS No. 79-10-7) vapour for 13 consecutive days during pregnancy. In the range-finding study, eight pregnant does/group were exposed to 30, 60, 125 or 250 ppm acrylic acid vapour on ges... | ['Abnormalities, Drug-Induced', 'Acrylates', 'Administration, Inhalation', 'Animals', 'Body Weight', 'Dose-Response Relationship, Drug', 'Eating', 'Female', 'Fetus', 'Male', 'Pregnancy', 'Rabbits'] | 9,409,627 | [['C16.131.042'], ['D02.241.081.069'], ['E02.319.267.050'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.203.650.283', 'G10.261.330'], ['A16.378'], ['G08.686.784.769'], ['B01.050.150.900.64... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Detection and characterization of monoclonal antibodies to platelet membrane proteins. | We have devised a solid-phase radioimmunoassay for the detection and characterization of monoclonal antibodies directed against platelet surface antigens. Platelet membrane proteins, solubilized with 0.1% Triton X-100, were covalently coupled to cyanogen bromide (CNBr)-activated filter paper disks that were than used a... | ['Antibodies', 'Antibodies, Monoclonal', 'Blood Platelets', 'Cyanogen Bromide', 'Filtration', 'Humans', 'Membrane Proteins', 'Octoxynol', 'Polyethylene Glycols', 'Radioimmunoassay'] | 6,788,781 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.118.188', 'A15.145.229.188'], ['D01.139.300.050.100', 'D01.625.175'], ['E05.196.454', 'G01.280', 'G02.263'], ['B01.050.150.900.649.313.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Report of the Conference on Low Blood Cholesterol: Mortality Associations. | BACKGROUND: A National Heart, Lung, and Blood Institute (NHLBI) Conference was held October 9-10, 1990, to review and discuss existing data on U-shaped relations found between mortality rates and blood total cholesterol levels (TC) in some but not other studies. Presentations were given from 19 cohort studies from the ... | ['Alcohol Drinking', 'Cardiovascular Diseases', 'Cholesterol', 'Clinical Trials as Topic', 'Cohort Studies', 'Female', 'Humans', 'International Cooperation', 'Male', 'Mortality', 'Neoplasms', 'Nutritional Physiological Phenomena', 'Risk Factors', 'Sex Characteristics', 'Smoking'] | 1,355,411 | [['F01.145.317.269'], ['C14'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.6... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Neural correlates of anxiety sensitivity during masked presentation of affective faces. | BACKGROUND: Anxiety Sensitivity (AS), the tendency to fear the thoughts, symptoms, and social consequences associated with the experience of anxiety, is associated with increased risk for developing anxiety disorders. Some evidence suggests that higher scores on the Anxiety Sensitivity Index (ASI), a measure of the AS ... | ['Adult', 'Anxiety Disorders', 'Brain', 'Brain Mapping', 'Cerebral Cortex', 'Dominance, Cerebral', 'Emotions', 'Facial Expression', 'Fear', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Pattern Recognition, Visual', 'Perceptual Masking', 'Personality Inventory'] | 21,308,886 | [['M01.060.116'], ['F03.080'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['F02.830.297', 'G11.561.225'], ['F01.470'], ['E01.370.600.225', 'F01.145.209.530.385'], ['F01.470.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
A self-biased neutron detector based on an SiC semiconductor for a harsh environment. | Neutron detector based on radiation-hard semiconductor materials like SiC, diamond and AlN has recently emerged as an attractive device for an in-core reactor neutron flux monitoring, a spent fuel characterization, and a home land security application. For the purpose of field measurement activity, a radiation detector... | ['Carbon Compounds, Inorganic', 'Equipment Design', 'Neutrons', 'Radiation Monitoring', 'Semiconductors', 'Silicon Compounds'] | 19,362,006 | [['D01.200'], ['E05.320'], ['G01.249.660.250'], ['E05.799.638', 'N06.850.780.375.700', 'N06.850.810.370'], ['E07.305.625'], ['D01.837']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Localizing components of a complex task: sentence processing and working memory. | Three areas of the left hemisphere play different roles in sentence comprehension. An area of posterior middle and superior temporal gyrus shows activation correlated with the structural complexity of a sentence, suggesting that this area supports processing of sentence structure. The lateral anterior temporal gyrus is... | ['Adult', 'Brain', 'Brain Mapping', 'Cognition', 'Female', 'Humans', 'Linear Models', 'Magnetic Resonance Imaging', 'Male', 'Memory', 'Photic Stimulation', 'Reading', 'Temporal Lobe', 'Tomography, Emission-Computed', 'Word Association Tests'] | 9,804,304 | [['M01.060.116'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
One Week of Daily Dosing With Beetroot Juice Improves Submaximal Endurance and Blood Pressure in Older Patients With Heart Failure and Preserved Ejection Fraction. | OBJECTIVES: This study sought to determine whether a relatively low single dose or a week-long dosage of dietary inorganic nitrate could improve exercise tolerance in patients with heart failure with preserved ejection fraction (HFpEF).BACKGROUND: Exercise intolerance is the primary manifestation of HFpEF and is largel... | ['Aged', 'Beta vulgaris', 'Blood Pressure', 'Cross-Over Studies', 'Double-Blind Method', 'Exercise Tolerance', 'Female', 'Fruit and Vegetable Juices', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Nitrates', 'Oxygen Consumption', 'Physical Endurance', 'Stroke Volume'] | 26,874,390 | [['M01.060.116.100'], ['B01.650.940.800.575.912.250.200.399'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G11.427.680.270'], ['G07.203.100.606', 'J02.200.606'], ['C... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort. | Rational flux design in metabolic engineering approaches remains difficult since important pathway information is frequently not available. Therefore empirical methods are applied that randomly change absolute and relative pathway enzyme levels and subsequently screen for variants with improved performance. However, sc... | ['Algorithms', 'Binding Sites', 'Computer Simulation', 'Indoles', 'Metabolic Engineering', 'Metabolic Networks and Pathways', 'Ribosomes'] | 27,029,461 | [['G17.035', 'L01.224.050'], ['G02.111.570.120'], ['L01.224.160'], ['D03.633.100.473'], ['E05.393.420.526', 'E05.481.500.311.249', 'J01.293.069.249.249'], ['G03.493'], ['A11.284.430.214.190.875.811']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Nervous factors influencing the membrane activity of intestinal smooth muscle. | The effects of various chemical agents on the spontaneous membrane activities and those electrically elicited in the smooth muscles of small intestine were investigated.1. The effects of various chemicals on the spontaneously active membrane might be summarized as follows. (a) Cholinergic agents; atropine slightly hype... | ['Animals', 'Atropine', 'Barium', 'Depression, Chemical', 'Electrophysiology', 'Guinea Pigs', 'Intestine, Small', 'Membrane Potentials', 'Muscle, Smooth', 'Oscillometry', 'Parasympathomimetics', 'Rabbits', 'Tetrodotoxin'] | 6,050,104 | [['B01.050'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['G07.690.773.750'], ['H01.158.344.528', 'H01.158.782.236'], ['B01.050.150.900.649.313.992.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethanol intake and 3H-serotonin uptake. II: A study in alcoholic patients using platelets 3H-paroxetine binding. | The kinetic parameters of 3H-paroxetine binding and 3H-serotonin uptake were studied in platelets of alcoholic patients. There was no difference between alcoholic and non alcoholic subjects in 3H-paroxetine binding. When binding and 3H-serotonin uptake were studied, in the same plasma of the same subjects, the Vmax of ... | ['Adult', 'Alcoholism', 'Blood Platelets', 'Humans', 'Kinetics', 'Middle Aged', 'Paroxetine', 'Piperidines', 'Serotonin', 'Serotonin Antagonists'] | 1,827,171 | [['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['A11.118.188', 'A15.145.229.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['M01.060.116.630'], ['D03.383.621.600'], ['D03.383.621'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.814', 'D23.469.050.650'], ['D27.505.5... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The influence of indomethacin on renal haemodynamics in sickle cell anaemia. | 1. Glomerular filtration rate and effective renal blood-flow were normal in a series of patients with sickle cell anaemia. Fractional creatinine excretion and fractional urea excretion were increased. 2. During indomethacin administration there were significant falls in glomerular filtration rate, effective renal blood... | ['Adolescent', 'Adult', 'Anemia, Sickle Cell', 'Female', 'Glomerular Filtration Rate', 'Humans', 'Indomethacin', 'Kidney', 'Male', 'Middle Aged', 'Regional Blood Flow', 'Urea'] | 7,428,292 | [['M01.060.057'], ['M01.060.116'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.420'], ['A05.810.453'], ['M01.060.116.630'], ['G09.330.100.780'], ['D02.065.950']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay). | The alkaline single cell gel test (SCG test or comet assay) was used to study the contribution of excision repair activity to the observed DNA effect after mutagen treatment. The cytotoxicity and genotoxicity of UV-irradiation and the chemical mutagens 4-nitroquinoline-1-oxide (4NQO), benzo[a]pyrene (BP) and 7,12-dimet... | ['4-Nitroquinoline-1-oxide', '9,10-Dimethyl-1,2-benzanthracene', 'Aphidicolin', 'Benzo(a)pyrene', 'Cell Survival', 'Cells, Cultured', 'DNA', 'Dose-Response Relationship, Drug', 'Electrophoresis, Agar Gel', 'Enzyme Inhibitors', 'Fibroblasts', 'Humans', 'Male', 'Mutagens', 'Ultraviolet Rays', 'Xeroderma Pigmentosum'] | 8,596,477 | [['D02.640.820.600', 'D03.633.100.810.470.450', 'D03.661.243.500'], ['D02.455.426.559.847.149.301', 'D04.615.149.301'], ['D02.455.849.291.075'], ['D02.455.426.559.847.799.306.300', 'D04.615.799.306.300'], ['G04.346'], ['A11.251'], ['D13.444.308'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.196.401.153', 'E05.301.300... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents. | Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO(2) release profiles with half-lives of SO(2) release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 ìM) of inhibiting Mycobacterium... | ['Antitubercular Agents', 'Cell Survival', 'Cysteine', 'HEK293 Cells', 'Humans', 'Kinetics', 'Microbial Sensitivity Tests', 'Mycobacterium tuberculosis', 'Sulfonamides', 'Sulfur Dioxide'] | 22,128,803 | [['D27.505.954.122.085.255'], ['G04.346'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B03.510.024.9... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Placing the trailing foot closer to an obstacle reduces flexion of the hip, knee, and ankle to increase the risk of tripping. | This study was performed to test the hypothesis that reducing the horizontal distance between the trailing foot (foot crossing the obstacle last) and obstacle, during stance just prior to stepping over the obstacle, would reduce flexion of the hip, knee, and ankle joints of the trailing limb when the toe is over the ob... | ['Accidental Falls', 'Adult', 'Analysis of Variance', 'Ankle Joint', 'Female', 'Foot', 'Gait', 'Hip Joint', 'Humans', 'Knee Joint', 'Logistic Models', 'Male', 'Movement', 'Range of Motion, Articular', 'Risk Factors', 'Rotation', 'Toes', 'Walking'] | 9,796,668 | [['N06.850.135.122'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A02.835.583.378.062'], ['A01.378.610.250'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['E05.318.740.500.525', 'E05.... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
In-shoe pressure distribution in "unstable" (MBT) shoes and flat-bottomed training shoes: a comparative study. | BACKGROUND: Footwear comfort in many clinical situations is dependent on the ability of the 'shoe' to redistribute plantar pressure. Offloading the metatarsal heads may be achieved by fitting an insole, but recently a new design of shoe with a curved under sole (Masai Barefoot Technology or "MBT shoe") has been advocat... | ['Adult', 'Biomechanical Phenomena', 'Biomimetics', 'Equipment Design', 'Female', 'Foot', 'Gait', 'Humans', 'Male', 'Pressure', 'Shoes'] | 16,901,702 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['H01.158.550.100', 'J01.897.120.100'], ['E05.320'], ['A01.378.610.250'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.715'], ['J01.637.215.800']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 |
Effect of cyclosporine on adrenocortical response to injury and infection. | The effects of cyclosporine administration on the adrenocortical response to the severe stress of burn wound sepsis were studied in Wistar rats. Animals were treated with cyclosporine (10 mg/kg/day) or saline by gavage for 10 days, then subjected to 30% scald burns with wound inoculation with Pseudomonas. Animals were ... | ['Adrenal Cortex', 'Adrenal Glands', 'Adrenocorticotropic Hormone', 'Animals', 'Burns', 'Corticosterone', 'Cyclosporine', 'DNA', 'Hyperplasia', 'Male', 'Organ Size', 'Proteins', 'Pseudomonas Infections', 'RNA', 'Rats', 'Rats, Wistar', 'Wound Infection'] | 1,383,613 | [['A06.300.071.140'], ['A06.300.071'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['B01.050'], ['C26.200'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.23... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nurses knowledge and attitudes regarding nutrition in the elderly. | BACKGROUND/AIMS: Nurses in the community are in contact with the elderly at different levels of care. The aim of this study was to assess nurses' knowledge and attitudes regarding nutritional-care for the elderly, and the impact of their attitude on the quality of assessment-care they provide to this growing population... | ['Adult', 'Age Factors', 'Aged', 'Attitude of Health Personnel', 'Clinical Competence', 'Data Collection', 'Humans', 'Israel', 'Middle Aged', "Nurse's Role", 'Nurses', 'Nutritional Sciences', 'Surveys and Questionnaires', 'Young Adult'] | 19,536,416 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F01.100.050', 'N05.300.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375'], ['M01.060.116.... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
A transcriptional regulatory element in the coding sequence of the human Bcl-2 gene. | We investigated the protein-binding sites in a DNAse I hypersensitive site associated with bcl-2 gene expression in human B cells. We mapped this hypersensitive site to the coding sequence of exon 2 of the bcl-2 gene in the bcl-2-expressing REH B-cell line. Electrophoretic mobility shift assays (EMSAs) with extracts fr... | ['Apoptosis', 'B-Lymphocytes', 'Base Sequence', 'Cell Differentiation', 'Deoxyribonuclease I', 'Electrophoretic Mobility Shift Assay', 'Enhancer Elements, Genetic', 'Gene Expression Regulation', 'Genes, Regulator', 'Genes, bcl-2', 'Humans', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides, Antisense', 'Palatine To... | 15,606,792 | [['G04.146.954.035'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.152'], ['D08.811.277.352.335.350.250'], ['E05.196.401.500'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', ... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of caffeine on exercise performance of physically fit Thoroughbreds. | OBJECTIVE: To determine the effects of a dose of caffeine (2.5 mg/kg, IV) administered to physically fit Thoroughbreds during incremental exercise testing to fatigue on a treadmill.ANIMALS: 10 conditioned Thoroughbreds.PROCEDURE: Horses were randomly assigned to receive caffeine or a control solution. Each horse receiv... | ['Animals', 'Caffeine', 'Carbon Dioxide', 'Central Nervous System Stimulants', 'Cross-Over Studies', 'Female', 'Heart Rate', 'Horses', 'Lactic Acid', 'Male', 'Oxygen Consumption', 'Physical Conditioning, Animal', 'Random Allocation'] | 15,900,934 | [['B01.050'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D27.505.696.282', 'D27.505.954.427.220'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.984.235.472'], ['D02.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Transmission of sugarcane white leaf phytoplasma by Yamatotettix flavovittatus, a new leafhopper vector. | Sugarcane white leaf disease is caused by plant pathogenic phytoplasmas that are transmitted to the plant by the leafhopper Matsumuratettix hiroglyphicus (Matsumura). To determine whether there are other insect vectors that transmit this disease pathogen, leafhopper species in sugarcane, Saccharum officinarum L., field... | ['Animals', 'Base Sequence', 'Hemiptera', 'Molecular Sequence Data', 'Plant Diseases', 'Population Dynamics', 'Saccharum', 'Sequence Analysis, DNA', 'Tenericutes'] | 17,066,780 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.500.131.617.412'], ['L01.453.245.667'], ['G15.610'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['B01.650.940.800.575.912.250.822.835'], ['E05.393.760.700'], ['B03.440.860']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Does binge eating disorder impact weight-related quality of life? | OBJECTIVES: To determine whether binge eating disorder (BED) impacts weight-related quality of life in obese individuals seeking weight loss treatment and to investigate the role of psychological symptoms, BMI, and demographic variables in the relationship between BED and weight-related quality of life.RESEARCH METHODS... | ['Age Factors', 'Body Mass Index', 'Bulimia', 'Depression', 'Female', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Obesity', 'Quality of Life', 'Sex Factors', 'Surveys and Questionnaires'] | 15,229,340 | [['N05.715.350.075', 'N06.850.490.250'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.821.645.500'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The antigastrolesive activity of rioprostil, a 16-methyl prostaglandin-E1 analogue in healthy volunteers. | The antigastrolesive activity of rioprostil, an orally effective synthetic 16-methyl analogue of prostaglandin-E1, with potent antisecretory and antigastrolesive properties in animals, is evaluated in a series of studies involving 166 healthy male volunteers. Three double-blind, randomized, parallel, placebo-controlled... | ['Adult', 'Anti-Ulcer Agents', 'Aspirin', 'Double-Blind Method', 'Gastric Mucosa', 'Humans', 'Male', 'Prostaglandins E', 'Prostaglandins, Synthetic', 'Randomized Controlled Trials as Topic', 'Rioprostil'] | 2,510,286 | [['M01.060.116'], ['D27.505.954.483.203'], ['D02.455.426.559.389.657.410.595.176'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.251.355.255.550.250', 'D23.469.050.175.725.250'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fixed and autoadjusting continuous positive airway pressure treatments are not similar in reducing cardiovascular risk factors in patients with obstructive sleep apnea. | BACKGROUND: A strong association between obstructive sleep apnea (OSA) and the risk for cardiovascular and cerebrovascular diseases has been reported. Continuous positive airway pressure (CPAP) is the first-line therapy for OSA, able not only to reduce daytime sleepiness but also to improve cardiovascular and metabolic... | ['Adult', 'Blood Glucose', 'Blood Pressure', 'Body Mass Index', 'C-Reactive Protein', 'Cardiovascular Diseases', 'Continuous Positive Airway Pressure', 'Female', 'Heart Rate', 'Humans', 'Inflammation', 'Insulin Resistance', 'Male', 'Middle Aged', 'Risk Factors', 'Sleep Apnea, Obstructive', 'Time Factors'] | 17,494,789 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C14'], ['E02.041.625.790.259', 'E02.880.820.790.259'], ['E01.370.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of dual-specificity protein phosphatase 5 on pluripotency maintenance and differentiation of mouse embryonic stem cells. | The MAPK/Erk signaling pathway is considered as a key regulator of the pluripotency and differentiation of embryonic stem (ES) cells, while dual-specificity protein phosphatases (DUSPs) are negative regulators of MAPK. Although DUSPs are potential embryogenesis regulators, their functions in the regulation of ES cell d... | ['Animals', 'Base Sequence', 'Blotting, Western', 'Cell Differentiation', 'Cell Line', 'DNA Primers', 'Dual-Specificity Phosphatases', 'Embryonic Stem Cells', 'Gene Knockdown Techniques', 'Homeodomain Proteins', 'Humans', 'Mice', 'Nanog Homeobox Protein', 'Real-Time Polymerase Chain Reaction', 'Signal Transduction'] | 21,732,408 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.152'], ['A11.251.210'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D08.811.277.352.650.625.225', 'D08.811.277.352.650.775... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Impact of anti-insulin antibodies on islet transplantation outcome: data from the GRAGIL Network. | BACKGROUND: In patients with type 1 diabetes, insulin antibodies (IA), altering the pharmacokinetics of circulating insulin, might be associated with high glucose concentration, prolonged hypoglycemia, and higher insulin requirement. The impact of IA on islet transplantation has never been explored. Our aim was to eval... | ['Adult', 'Blood Glucose', 'Case-Control Studies', 'Female', 'Humans', 'Insulin Antibodies', 'Insulin Resistance', 'Islets of Langerhans Transplantation', 'Male', 'Middle Aged', 'Retrospective Studies', 'Treatment Outcome'] | 24,837,539 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.656', 'D12.776.124.790.651.114.656', 'D12.776.377.715.548.114.656'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Peripheral esterases in the rat: effects of classical inducers. | Liver microsomal paraoxonase, aryl esterase and fluazifop butyl esterase (carboxylesterase) were induced by pretreatment of rat with phenobarbitone but not by beta-naphthoflavone or clofibric acid. In the extrahepatic tissues lung cytosolicfluazifop butyl and phenylacetate esterase were induced. | ['Animals', 'Benzoflavones', 'Clofibric Acid', 'Enzyme Induction', 'Esterases', 'Herbicides', 'Hydrolysis', 'Inactivation, Metabolic', 'Liver', 'Lung', 'Male', 'Paraoxon', 'Phenobarbital', 'Phenylacetates', 'Pyridines', 'Rats', 'Rats, Wistar', 'Skin', 'beta-Naphthoflavone'] | 8,343,974 | [['B01.050'], ['D03.383.663.283.266.450.175', 'D03.633.100.150.266.450.175'], ['D02.241.081.114.968.500.500', 'D02.355.726.305.500', 'D02.455.426.559.389.657.654.305.500'], ['G05.308.320.200'], ['D08.811.277.352'], ['D27.720.031.700.366', 'D27.888.723.366'], ['G02.380'], ['G03.171.450', 'G03.787.225.450', 'G07.690.725.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predicting recovery criteria for threatened and endangered plant species on the basis of past abundances and biological traits. | Recovery plans for species listed under the U.S. Endangered Species Act are required to specify measurable criteria that can be used to determine when the species can be delisted. For the 642 listed endangered and threatened plant species that have recovery plans, we applied recursive partitioning methods to test wheth... | ['Conservation of Natural Resources', 'Endangered Species', 'Models, Biological', 'Plant Development', 'Plant Dispersal', 'Plant Physiological Phenomena', 'Population Dynamics', 'United States'] | 23,293,869 | [['J01.256', 'N06.230.080'], ['B01.050.050.565', 'G16.500.275.157.049.250', 'N06.230.080.200', 'N06.230.124.049.250'], ['E05.599.395'], ['G07.345.625', 'G15.589'], ['G15.620'], ['G15'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['Z01.107.567.875']] | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Autoproteolysis in nucleoporin biogenesis. | We have molecularly characterized a proteolytic cleavage in conserved nuclear pore complex proteins. This cleavage, previously demonstrated to be essential for the biogenesis of two nuclear pore complex proteins in mammals (Nup98 and Nup96) and yeast (Nup145-N and Nup145-C), occurs between Phe and Ser residues within a... | ['Amino Acid Sequence', 'Conserved Sequence', 'Endopeptidases', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Nuclear Envelope', 'Nuclear Proteins'] | 10,500,183 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.580'], ['D08.811.277.656.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.365.590'], ['A11.284.149.165.630', 'A11.284.149.450.700', 'A11.284.430.106.279.692', 'A11.284.835.514.700'], ['D12.776.660']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Spacer-elongated cell wall fusion proteins improve cell surface expression in the yeast Saccharomyces cerevisiae. | Fusion proteins for cell surface expression in the yeast Saccharomyces cerevisiae were constructed that consisted of the N-terminal leader sequence of Kre1p, followed by the nine amino acid viral epitope hemagglutinin (HA), and the carboxyterminal anchoring domain of either Cwp2p or Flo1p. All fusions were constitutive... | ['Cell Wall', 'Fungal Proteins', 'Gene Expression', 'Hemagglutinins', 'Membrane Proteins', 'Models, Genetic', 'Recombinant Fusion Proteins', 'Saccharomyces cerevisiae'] | 11,956,747 | [['A11.284.183'], ['D12.776.354'], ['G05.297'], ['D27.505.696.477.136.377'], ['D12.776.543'], ['E05.599.395.397'], ['D12.776.828.300'], ['B01.300.107.795.785.800', 'B01.300.930.705.655']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An interactive wireless communication system for visually impaired people using city bus transport. | Visually impaired people have difficulty accessing information about public transportation systems. Several systems have been developed for assisting visually impaired and blind people to use the city bus. Most systems provide only one-way communication and require high-cost and complex equipment. The purpose of this s... | ['Cities', 'Computer Communication Networks', 'Female', 'Humans', 'Male', 'Middle Aged', 'Motor Vehicles', 'Self-Help Devices', 'Taiwan', 'Transportation', 'Urban Population', 'Visually Impaired Persons', 'Wireless Technology'] | 24,776,720 | [['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['L01.224.230.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['J01.937.500'], ['E07.796'], ['Z01.252.474.872', 'Z01.639.850'], ['J01.937'], ['N01.600.900'], ['M01.150.850'], ['L01.178.847.950']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
A comparison of graph- and kernel-based -omics data integration algorithms for classifying complex traits. | BACKGROUND: High-throughput sequencing data are widely collected and analyzed in the study of complex diseases in quest of improving human health. Well-studied algorithms mostly deal with single data source, and cannot fully utilize the potential of these multi-omics data sources. In order to provide a holistic underst... | ['Algorithms', 'Bayes Theorem', 'Computational Biology', 'Humans', 'Support Vector Machine'] | 29,212,468 | [['G17.035', 'L01.224.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['H01.158.273.180', 'L01.313.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G17.035.250.500.500.500', 'L01.224.050.375.530.500.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Bone allografts in salvage of difficult hip arthroplasties. | Fourteen bone allograft transplantations were performed in 12 patients: five whole-hip osteoarticular allografts, eight acetabular wall, and one proximal femur with long-stem prosthesis. Average followup time was 19 months. Average patient age was 46 years. Acetabular grafts appeared healed. There was narrowing of join... | ['Acetabulum', 'Adult', 'Aged', 'Female', 'Femur', 'Follow-Up Studies', 'Hip Joint', 'Hip Prosthesis', 'Humans', 'Middle Aged', 'Prospective Studies', 'Radiography', 'Transplantation, Homologous'] | 4,017,328 | [['A02.835.232.043.825.108'], ['M01.060.116'], ['M01.060.116.100'], ['A02.835.232.043.150'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A02.835.583.411'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.62... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382. | Roscovitine has been shown to induce the accumulation of the tumor suppressor p53, to arrest cells in the G(1) and G(2)/M phases of the cell cycle, and to induce apoptosis in human cells. Although these cellular effects of roscovitine are thought to be caused directly by its specific inhibition of cyclin-dependent kina... | ['CDC2-CDC28 Kinases', 'Cell Nucleus', 'Cells, Cultured', 'Cyclin-Dependent Kinase 2', 'Cyclin-Dependent Kinases', 'Enzyme Inhibitors', 'Humans', 'Lysine', 'Nucleic Acid Synthesis Inhibitors', 'Phosphorylation', 'Protein-Serine-Threonine Kinases', 'Purines', 'RNA Polymerase II', 'RNA, Messenger', 'Roscovitine', 'Serine... | 11,562,441 | [['D08.811.913.696.620.682.700.646.500.500', 'D12.644.360.250.067', 'D12.776.167.200.067', 'D12.776.476.250.067'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.251'], ['D08.811.913.696.620.682.700.646.500.750', 'D12.644.360.250.323', 'D12.776.167.200.323', 'D12.776.476.250.323'], ['D08.811.913.696.620.682.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variations in the abundance and structural diversity of microbes forming biofilms in a thermally stressed coral reef system. | Little information is known about biofilm formation in the thermally stressed coral reef systems north of the Arabian Gulf. The current study investigates the abundance and diversity of marine microbes involved in biofilm formation and their succession over a period of 14 weeks (May-August 2007) at temperatures exceedi... | ['Animals', 'Anthozoa', 'Biodiversity', 'Biofilms', 'Calcium Carbonate', 'Coral Reefs', 'Larva', 'Metamorphosis, Biological', 'Microbial Consortia', 'Rhodophyta', 'Temperature', 'Vibrio'] | 26,494,248 | [['B01.050'], ['B01.050.500.308.237'], ['G16.500.275.157.049', 'N06.230.124.049'], ['A20.593', 'G06.120'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['G16.500.275.157.130', 'N06.230.124.130'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G07.345.500.550'], ['G06.591.750', 'G16.500.275.157.049.100.500.750'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Selective autoantibody production against CCL3 is associated with human type 1 diabetes mellitus and serves as a novel biomarker for its diagnosis. | We have recently demonstrated that patients suffering from chronic autoimmune diseases develop an autoantibody response against key mediators that participate in the initiation and progression of these diseases. In this paper, we show that patients with type 1 diabetes mellitus (T1DM), but not those suffering from seve... | ['Adolescent', 'Adult', 'Antibody Formation', 'Antibody Specificity', 'Autoantibodies', 'Biomarkers', 'Cell Line', 'Chemokine CCL3', 'Child', 'Child, Preschool', 'Diabetes Mellitus, Type 1', 'Humans', 'Infant'] | 19,494,336 | [['M01.060.057'], ['M01.060.116'], ['G12.450.050.370.250'], ['G12.100'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D23.101'], ['A11.251.210'], ['D12.644.276.374.200.110.150', 'D12.644.276.374.200.600.150', 'D12.776.467.374.200.110.150', 'D12.776.467.374.200.600.150... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical features of the arthritis of mixed connective tissue disease. | Seventeen of 19 patients with mixed connective tissue disease (MCTD) had arthritis as a significant initial feature of their disease; 8 were given an initial diagnosis of rheumatoid arthritis (RA) and 4 received chrysotherapy. RA-like hand deformities were present in 35% and contractures and/or persistent loss of joint... | ['Adolescent', 'Adult', 'Aged', 'Arthritis, Rheumatoid', 'Child', 'Collagen Diseases', 'Female', 'Humans', 'Male', 'Middle Aged', 'Radiography'] | 666,870 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['M01.060.406'], ['C17.300.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Arthrodesis after osteosynthesis and infection of the ankle joint. | Nineteen patients with a severely infected ankle joint after previous osteosynthesis were treated with arthrodesis in our institution. Their notes and X-rays were reviewed. Goals of treatment were eradication of infection by aggressive d?bridement of infected tissues, obtaining adequate soft-tissue coverage, preservati... | ['Adolescent', 'Adult', 'Aged', 'Ankle Injuries', 'Arthrodesis', 'Bone Transplantation', 'Female', 'Follow-Up Studies', 'Fracture Fixation, Internal', 'Humans', 'Male', 'Middle Aged', 'Muscles', 'Radiography', 'Reoperation', 'Retrospective Studies', 'Surgical Wound Infection', 'Treatment Outcome'] | 11,223,046 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C26.558.100'], ['E04.555.100'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.555.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cytochemical and immunofluorescence investigations of insulin-like producing cells in the intestine of Mytilus edulis L. (Bivalvia). | Insulin-like immunoreactivity can be localized to cells of the intestine in the area of the hepatopancreas of Mytilus edulis L. No cross-reactivity can be obtained with anti-glucagon, anti-gastrin, anti-pentagastrin or anti-caerulin. The cells containing the substance immunoreactive to mammalian anti-insulin, can be re... | ['Animals', 'Bivalvia', 'Ceruletide', 'Cross Reactions', 'Epithelial Cells', 'Epithelium', 'Fluorescent Antibody Technique', 'Gastrins', 'Gastrointestinal Hormones', 'Glucagon', 'Insulin', 'Intestinal Mucosa'] | 764,973 | [['B01.050'], ['B01.050.500.644.080'], ['D12.644.456.241'], ['G12.122.281'], ['A11.436'], ['A10.272'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D06.472.317.413', 'D06.472.699.280', 'D12.644.400.320', 'D12.644.548.280', 'D1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A highly selective fluorescent probe for hypochlorite and its endogenous imaging in living cells. | An oxime based fluorescent probe has been designed and synthesized, which detects free as well as enzymatically generated hypochlorite with a low detection limit and high sensitivity. In addition, the probe was successfully utilized for the monitoring of endogenously produced hypochlorite in LPS stimulated cell lines, ... | ['Animals', 'Cell Line', 'Cell Line, Tumor', 'Fluorescent Dyes', 'Humans', 'Hypochlorous Acid', 'Mice', 'Models, Molecular', 'Optical Imaging', 'Oximes', 'Spectrometry, Fluorescence'] | 25,155,881 | [['B01.050'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.029.260.365', 'D01.210.465', 'D01.339.431.311', 'D01.650.550.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595'], ['E01.370.350.58... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin) conjugated polyethylenimine. | A series of novel nonviral vectors targeting the HER-2/neu gene product human epidermal growth factor receptor-2 (HER2) were constructed and evaluated in breast cancer cell lines to optimize vector formulation for receptor-specific gene transfer. These vectors were DNA/polycation complexes (polyplexes) prepared by mixi... | ['Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Cell Line, Tumor', 'DNA', 'Drug Carriers', 'Electrophoresis, Agar Gel', 'Humans', 'Luciferases, Firefly', 'Plasmids', 'Polyethyleneimine', 'Receptor, ErbB-2', 'Transfection', 'Trastuzumab'] | 15,196,762 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['A11.251.210.190', 'A11.251.860.180'], ['D13.444.308'], ['D26.255.260', 'E02.319.300.380'], ['E05.196.401.153', 'E05... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Evaluation of a prepared childbirth program. | A study was undertaken to ascertain what effects on the outcome of labor and delivery could be attributed to a prepared childbirth program. Three tables are included setting forth statistical relationships. The basic conclusion was that more than five hours of structured prenatal education has a positive impact on mate... | ['Delivery, Obstetric', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Infant, Newborn', 'Labor, Obstetric', 'Male', 'Pregnancy', 'Prenatal Care', 'Washington'] | 251,741 | [['E04.520.252'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769.326'], ['G08.686.784.769'], ['E02.760.786', 'N02.421.143.620.704', 'N02.421.585.786'], ['Z01.107.567.875.560.900', 'Z01.107.567.875.580.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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