Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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A stopped flow transient kinetic analysis of substrate binding and catalysis in Escherichia coli D-3-phosphoglycerate dehydrogenase. | Pre-steady state, stopped flow analysis of Escherichia coli D-3-phosphoglycerate dehydrogenase was performed by following the fluorescence of protein tryptophan and the fluorescence resonance energy transfer from protein tryptophan to bound NADH. The results indicate that binding of substrates is ordered, with coenzyme... | ['Catalysis', 'Escherichia coli', 'Kinetics', 'Models, Biological', 'Models, Chemical', 'Molecular Conformation', 'NAD', 'Oxygen', 'Phosphoglycerate Dehydrogenase', 'Protein Binding', 'Protein Structure, Tertiary', 'Spectrophotometry', 'Substrate Specificity', 'Time Factors'] | 18,776,184 | [['G02.130'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['E05.599.495'], ['G02.111.570.820'], ['D03.633.100.759.646.138.694', 'D08.211.589', 'D13.695.667.138.694', 'D13.695.827.068.694'], ['D01.268.185.550', 'D01.362.670'], ['D08.811.682.047.150.650'], ['G0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased urine podocyte-associated messenger RNAs in severe obesity are evidence of podocyte injury. | OBJECTIVE: The aim of this study was to correlate different degrees of excess weight with the expression of podocyte-associated messenger RNAs (mRNAs) in urine.METHODS: The sample comprised 83 patients with overweight or obesity class I, II, or III and 18 healthy controls. The expression of nephrin, podocin, podocalyxi... | ['Adult', 'Cross-Sectional Studies', 'Female', 'Humans', 'Hyperinsulinism', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Podocytes', 'RNA, Messenger'] | 26,147,062 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968'], ['M01.060.116.630'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.699.500.500', 'G07.100.100.160.120.699.500.500'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lack of expression of long-term potentiation in the dentate gyrus but not in the CA1 region of the hippocampus of mu-opioid receptor-deficient mice. | The possible involvement of the mu-opioid receptor subtype in mechanisms of long-term potentiation (LTP) of the lateral perforant pathway to the dentate gyrus neurons, as well as of the Schaffer collateral-commissural input of CA1 neurons, was investigated using mu-opioid receptor-deficient mutant mice. In transversal ... | ['Action Potentials', 'Animals', 'Corpus Striatum', 'Dentate Gyrus', 'Female', 'Hippocampus', 'In Vitro Techniques', 'Long-Term Potentiation', 'Male', 'Mice', 'Mice, Mutant Strains', 'Naltrexone', 'Narcotic Antagonists', 'Receptors, Dopamine D1', 'Receptors, Dopamine D2', 'Receptors, Glutamate', 'Receptors, Opioid, mu'... | 10,727,705 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A08.186.211.200.885.287.249.487'], ['A08.186.211.180.405.200', 'A08.186.211.200.885.287.500.345.200'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E05.481'], ['G11.561.638.350'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical implication of orbital ultrasound monitoring during selective cerebral perfusion. | BACKGROUND: We evaluated clinical relevance of orbital ultrasound (OUS) monitoring to neurological events in aortic surgery associated with selective cerebral perfusion (SCP).METHODS: In 24 consecutive cases, blood flow was monitored at central retinal artery (CRA) and retrobulbar vessels. The threshold perfusion press... | ['Aged', 'Aneurysm, Dissecting', 'Aortic Aneurysm, Thoracic', 'Blood Flow Velocity', 'Brain', 'Brain Ischemia', 'Female', 'Humans', 'Male', 'Middle Aged', 'Orbit', 'Reference Values', 'Retinal Artery', 'Sensitivity and Specificity', 'Ultrasonography, Doppler, Color', 'Ultrasonography, Doppler, Transcranial'] | 11,235,726 | [['M01.060.116.100'], ['C14.907.055.050'], ['C14.907.055.239.125', 'C14.907.109.139.125'], ['E01.370.370.130', 'G09.330.380.630.080'], ['A08.186.211'], ['C10.228.140.300.150', 'C14.907.253.092'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.835.232.781.324.690'], ['E05.978.810'], ['A07.01... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Laser treatment of sinusitis in general practice assessed by a double-blind controlled study]. | The effect of Low Level Laser therapy (Galium-Aluminium-Arsenide laser, 30 mW/830 nm, Unilaser 2000 3B) on sinuitis was evaluated in a double-blind randomised clinical study comprising 60 patients from general practice. All patients received three treatments (90 seconds radiation on each sinus) with one to three days i... | ['Adolescent', 'Adult', 'Child', 'Denmark', 'Double-Blind Method', 'Family Practice', 'Female', 'Humans', 'Laser Therapy', 'Male', 'Middle Aged', 'Sinusitis'] | 1,882,473 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['Z01.542.816.124'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['M01.060.116.630'], ['C01.748.749', 'C08.460.692.752', 'C08.73... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Effect of prolonged heat stress in single-comb white leghorn hens on progeny resistance to Salmonella enteritidis organ invasion. | In our laboratory, we have often had difficulty infecting neonatal chickens with invasive salmonellae when ambient temperatures exceed 30 C. We hypothesized that this increased resistance in chicks during warmer months may be associated with heat stress-associated maternal factors. Presently, single-comb white leghorn ... | ['Animals', 'Case-Control Studies', 'Chickens', 'Colony Count, Microbial', 'Disease Susceptibility', 'Female', 'Heat Stress Disorders', 'Oviposition', 'Poultry Diseases', 'Random Allocation', 'Salmonella Infections, Animal', 'Salmonella enteritidis', 'Seasons', 'Time Factors'] | 11,417,832 | [['B01.050'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E01.370.225.875.220', 'E05.200.875.220'], ['C23.550.291.687', 'G07.100.250'], ['C26.522'], ['G08.686.784.480'], ['C22.131.728'], ['E05.318.370.700', 'E05.581.500... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A simple methodological validation of the gas/particle fractionation of polycyclic aromatic hydrocarbons in ambient air. | The analysis of polycyclic aromatic hydrocarbons (PAH) in ambient air requires the tedious experimental steps of both sampling and pretreatment (e.g., extraction or clean-up). To replace pre-existing conventional methods, a simple, rapid, and novel technique was developed to measure gas-particle fractionation of PAH in... | ['Air Pollutants', 'Calibration', 'Chemical Fractionation', 'Gas Chromatography-Mass Spectrometry', 'Gases', 'Limit of Detection', 'Particulate Matter', 'Polycyclic Aromatic Hydrocarbons'] | 26,126,962 | [['D27.888.284.101'], ['E05.978.155'], ['E05.196.155'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D01.362'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D20.633'], ['D02.455.426.559.847', 'D04.615']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A comparative metabolomic study of NHR-49 in Caenorhabditis elegans and PPAR-alpha in the mouse. | Proton Nuclear Magnetic Resonance spectroscopy and Gas Chromatography Mass Spectrometry based metabolomics has been used in conjunction with multivariate statistics to examine the metabolic changes in Caenorhabditis elegans following the deletion of nuclear hormone receptor-49 (nhr-49). Deletion of the receptor produce... | ['Animals', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Fatty Acids', 'Gas Chromatography-Mass Spectrometry', 'Gluconeogenesis', 'Glycolysis', 'Liver', 'Mice', 'Nuclear Magnetic Resonance, Biomolecular', 'PPAR alpha', 'Receptors, Cytoplasmic and Nuclear'] | 18,435,929 | [['B01.050'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['D10.251'], ['E05.196.181.349.500', 'E05.196.566.500'], ['G02.111.158.500', 'G03.191.500'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.196.867.519.550']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Strategic management of hospitals in France: balance and perspectives]. | The strategic management was introduced in French hospitals in the late 80s, in a context of inefficiency and the need to control healthcare expenditure. This concept has inspired a series of government reforms, the organization and dynamics of hospitals and the mode of regulating the French health system, assuming a r... | ['Delivery of Health Care', 'France', 'Hospital Administration'] | 20,802,862 | [['N04.590.374', 'N05.300'], ['Z01.542.286'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452']] | ['Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
DIANA-microT web server: elucidating microRNA functions through target prediction. | Computational microRNA (miRNA) target prediction is one of the key means for deciphering the role of miRNAs in development and disease. Here, we present the DIANA-microT web server as the user interface to the DIANA-microT 3.0 miRNA target prediction algorithm. The web server provides extensive information for predicte... | ['Algorithms', 'Binding Sites', 'Gene Expression Regulation', 'MicroRNAs', 'RNA, Messenger', 'Sequence Analysis, RNA', 'Software', 'User-Computer Interface'] | 19,406,924 | [['G17.035', 'L01.224.050'], ['G02.111.570.120'], ['G05.308'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['D13.444.735.544'], ['E05.393.760.710'], ['L01.224.900'], ['L01.224.900.910']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Further development of a physical function scale on a MDHAQ [corrected] for standard care of patients with rheumatic diseases. | OBJECTIVE: To analyze a further version of the Multidimensional Health Assessment Questionnaire (MDHAQ) with 10 activities of daily living (ADL), which is more easily completed by patients and scored by health professionals than a 14-ADL MDHAQ; and to determine if the 10-ADL MDHAQ would be as informative as the 14-ADL ... | ['Activities of Daily Living', 'Adult', 'Aged', 'Disability Evaluation', 'Female', 'Health Status Indicators', 'Humans', 'Male', 'Middle Aged', 'Reproducibility of Results', 'Rheumatic Diseases', 'Surveys and Questionnaires'] | 16,078,316 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.400'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.725', 'E05.337.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Effects on the prostate of environmental cadmium exposure--a cross-sectional population study in China. | To explore possible effects of environmental cadmium exposure on prostate in humans, and the possible relationship of serum sex hormones to occurrence of clinic signs of tissue changes in the prostate, a case-control study was undertaken in the southeast part of China in 1998. A total of 297 male volunteers from a cont... | ['Adult', 'Aged', 'Cadmium', 'Case-Control Studies', 'China', 'Cross-Sectional Studies', 'Environmental Exposure', 'Gonadal Steroid Hormones', 'Humans', 'Male', 'Middle Aged', 'Palpation', 'Prostate', 'Prostate-Specific Antigen'] | 15,688,864 | [['M01.060.116'], ['M01.060.116.100'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.252.474.164'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N06.850.460.350'], ['D06.472.334.851'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Genetic analysis of infectious diseases: estimating gene effects for susceptibility and infectivity. | BACKGROUND: Genetic selection of livestock against infectious diseases can complement existing interventions to control infectious diseases. Most genetic approaches that aim at reducing disease prevalence assume that individual disease status (infected/not-infected) is solely a function of its susceptibility to a parti... | ['Algorithms', 'Animals', 'Communicable Diseases', 'Computer Simulation', 'Genetic Heterogeneity', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Host-Pathogen Interactions', 'Humans', 'Models, Genetic', 'Models, Statistical', 'Selection, Genetic'] | 26,537,023 | [['G17.035', 'L01.224.050'], ['B01.050'], ['C01.221', 'C23.550.291.531'], ['L01.224.160'], ['G05.365.331'], ['C23.550.291.687.500', 'G05.380.355'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['G06.462', 'G16.527.200'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Improvement of vitamin D status via daily intake of fortified yogurt drink either with or without extra calcium ameliorates systemic inflammatory biomarkers, including adipokines, in the subjects with type 2 diabetes. | CONTEXT: Systemic inflammation is thought to have a central role in diabetic long-term complications.OBJECTIVE: The aim of this study was to investigate the effects of vitamin D either with or without extra calcium on certain inflammatory biomarkers in the subjects with type 2 diabetes (T2D).DESIGN, SETTING, AND PARTIC... | ['Adiponectin', 'Adult', 'Biomarkers', 'Calcium, Dietary', 'Cells, Cultured', 'Cytokines', 'Diabetes Mellitus, Type 2', 'Female', 'Food, Fortified', 'Humans', 'Inflammation', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Vitamin D', 'Vitamins', 'Yogurt'] | 22,442,277 | [['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['M01.060.116'], ['D23.101'], ['D01.146.395'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C18.452.394.750.149', 'C19.246.300'], ['G07.203.300.515', 'J02.500.515'], ['B01.050.150.9... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Blood lipids in Italy. Regional differences. | Serum cholesterol and triglyceride levels have been evaluated in samples from fasting males aged 20--59 in Northern (Brisighella), Central (Rome) and Southern (Pozzuoli) Italy. Regularly performed quality controls between laboratories assured comparability of data. A statisitically significant difference of mean serum ... | ['Adult', 'Age Factors', 'Cholesterol', 'Feeding Behavior', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Triglycerides'] | 728,233 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['D10.351.801']] | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A new p21waf1/cip1 isoform is an early event of cell response to oxidative stress. | p21waf1/cip1 mRNA and protein accumulate in intact cells exposed to oxidizing agents through a p53-independent, MAPK-dependent mechanism. Treatment with oxidizing agents also yields a second form of this protein (FM p21), characterized by a faster migration on SDS-PAGE. This phenomenon depends on the modification of in... | ['Animals', 'Base Sequence', 'COS Cells', 'Cyclin-Dependent Kinase Inhibitor p21', 'Cyclins', 'DNA Primers', 'Glutathione', 'HeLa Cells', 'Humans', 'Maleates', 'Oxidative Stress', 'Phosphorylation', 'Protein Processing, Post-Translational', 'RNA, Messenger', 'Tetradecanoylphorbol Acetate'] | 9,846,180 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['D12.644.360.262', 'D12.776.167.218', 'D12.776.476.262'], ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Remodeling of the plasma membrane in preparation for sperm-egg recognition: roles of acrosomal proteins. | The interaction of sperm with the egg's extracellular matrix, the zona pellucida (ZP) is the first step of the union between male and female gametes. The molecular mechanisms of this process have been studied for the past six decades with the results obtained being both interesting and confusing. In this article, we de... | ['Acrosome', 'Cell Membrane', 'Female', 'Humans', 'Male', 'Ovum', 'Sperm Capacitation', 'Sperm-Ovum Interactions', 'Spermatozoa', 'Zona Pellucida'] | 25,994,642 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['A11.284.149'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['G08.686.784.277.760'], ['G08.686.784.277.800'], ['A05.360.490.890', 'A11.497.760'], ['A05.360.490.690.950', 'A11.... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of protein synthesis by vaccinia virus. II. Studies on the role of virus-induced RNA synthesis. | Cytoplasmic RNA synthesis can be detected in vaccinia virus-infected HeLa cells in the presence of 2 micrograms/ml but not 20 micrograms/ml of actinomycin D. When RNA synthesis is observed protein synthesis is inhibited in infected, treated cells. We had previously noted that such a correlation may also be observed in ... | ['Cycloheximide', 'Dactinomycin', 'HeLa Cells', 'Humans', 'L Cells', 'Neoplasm Proteins', 'Phosphorylation', 'RNA, Double-Stranded', 'RNA, Messenger', 'RNA, Neoplasm', 'RNA, Viral', 'Ribosomal Proteins', 'Vaccinia virus'] | 528,979 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diversity of immunoglobulin light chain usage in the human immune response to Haemophilus influenzae type b capsular polysaccharide. | The response to the capsular polysaccharide of Haemophilus influenzae type b (Hib PS) has been used to determine the molecular basis of antibody gene diversity in humans. In contrast to the relatively restricted nature of anti-Hib PS heavy-chain variable region gene expression, a variety of light-chain variable region ... | ['Amino Acid Sequence', 'Antibodies, Bacterial', 'Antibodies, Monoclonal', 'Antibody Diversity', 'Bacterial Capsules', 'Bacterial Vaccines', 'Base Sequence', 'DNA', 'Genes, Immunoglobulin', 'Haemophilus Vaccines', 'Humans', 'Hybridomas', 'Immunoglobulin Light Chains', 'Molecular Sequence Data', 'Polysaccharides, Bacter... | 8,460,070 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G05.365.036', 'G12.500.199'], ['A20.186'], ['D20.215.894.135'], ['G02.111.570.080',... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Study on the toxicity of horseshoe crabs in mice]. | In order to study the toxicity of horseshoe crabs(tachypleus tridentatus and carcinoscorpius rotundicauda) in the sea of China, the extracts of tissues from tachypleus tridentatus and carcinoscorpius rotundicauda were injected into the abdominal cavity of mice for testing their poisoning effects. The results showed tha... | ['Animals', 'Arthropods', 'Female', 'Foodborne Diseases', 'Horseshoe Crabs', 'Male', 'Mice', 'Tissue Extracts'] | 12,725,072 | [['B01.050'], ['B01.050.500.131'], ['C25.723.415'], ['B01.050.500.131.450'], ['B01.050.150.900.649.313.992.635.505.500'], ['D20.777']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Study on chemical constituents of Cinnamomi Ramulus]. | The chemical constituents of Cinnamomi Ramulus were investigated in this study. Twenty-two compounds were isolated by silica gel, Sephadex LH-20 gel column chromatographies and preparative HPLC and their structures were identified by various spectral analyses as dihydrorosavin(1), rosavin(2), 1-phenyl-propane-1,2,3-tri... | ['Chromatography, High Pressure Liquid', 'Cinnamomum', 'Drugs, Chinese Herbal', 'Phytochemicals'] | 32,237,421 | [['E05.196.181.400.300'], ['B01.650.940.800.575.912.250.595.400.149'], ['D20.215.784.500.350', 'D26.335'], ['D23.704']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute and chronic brain infarcts on MR imaging in a 20-year-old woman with acute posterior multifocal placoid pigment epitheliopathy. | A 20-year-old woman recently diagnosed with acute posterior multifocal placoid pigment epitheliopathy developed headaches, weakness, and paresthesias. MR imaging of the brain revealed an acute infarct (demonstrated by diffusion-weighted images) in the head of the right caudate nucleus, a chronic infarct with encephalom... | ['Acute Disease', 'Adult', 'Brain', 'Brain Infarction', 'Caudate Nucleus', 'Choroid Diseases', 'Chronic Disease', 'Corpus Callosum', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Pigment Epithelium of Eye', 'Retinal Diseases'] | 16,418,358 | [['C23.550.291.125'], ['M01.060.116'], ['A08.186.211'], ['C10.228.140.300.150.477', 'C10.228.140.300.775.200', 'C14.907.253.092.477', 'C14.907.253.855.200', 'C23.550.513.355.250', 'C23.550.717.489.250'], ['A08.186.211.200.885.287.249.487.550.184'], ['C11.941.160'], ['C23.550.291.500'], ['A08.186.211.200.885.800.750'], ... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The prevalence of venous thromboembolism in rectal surgery: a systematic review and meta-analysis. | PURPOSE: Venous thromboembolism (VTE) following rectal surgery is a significant and preventable cause of morbidity and mortality, yet the true prevalence is not well established. This systematic review and meta-analysis assessed the available literature and determined its prevalence following rectal surgery.METHODS: A ... | ['Digestive System Surgical Procedures', 'Humans', 'Laparoscopy', 'Minimally Invasive Surgical Procedures', 'Prevalence', 'Publication Bias', 'Rectum', 'Risk Factors', 'Robotics', 'Venous Thromboembolism'] | 30,824,975 | [['E04.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E04.502'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['L01.737.813'], ['A03.556.124.526.767', 'A03.556.249.249.767'], ['E05.318.740.600.800... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Measuring In Vivo Tissue Metabolism Using 13 | Metabolic alterations are a hallmark of cancer. While determining metabolic changes in vitro has delivered valuable insight into the metabolism of cancer cells, it emerges that determining the in vivo metabolism adds an additional layer of information. Here, we therefore describe how to measure the in vivo metabolism o... | ['Animals', 'Carbon Isotopes', 'Gas Chromatography-Mass Spectrometry', 'Glucose', 'Metabolomics', 'Mice', 'Mice, Inbred C57BL', 'Neoplasms', 'Xenograft Model Antitumor Assays'] | 30,315,460 | [['B01.050'], ['D01.268.150.075', 'D01.496.123'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D09.947.875.359.448'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['C04'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Method of mapping DNA replication origins. | We have developed a method which allows determination of the direction in which replication forks move through segments of chromosomal DNA for which cloned probes are available. The method is based on the facts that DNA restriction fragments containing replication forks migrate more slowly through agarose gels than do ... | ['Chromatography', 'Chromosome Mapping', 'DNA Replication', 'DNA Restriction Enzymes', 'DNA, Single-Stranded', 'DNA, Viral', 'Electrophoresis, Agar Gel', 'Genes, Regulator', 'Simian virus 40'] | 2,984,557 | [['E05.196.181'], ['E05.393.183'], ['G02.111.225', 'G05.226'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D13.444.308.568'], ['E05.196.401.153', 'E05.301.300.100'], ['G05.360.340.024.340.425'], ['B04.280.210.700... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Status epilepticus induced by lithium-pilocarpine in the immature rat does not change the long-term susceptibility to seizures. | The causal relationship between early seizures and subsequent temporal lobe epilepsy has not yet been established. Prospective clinical studies reported that seizures occurring early in life rarely result in hippocampal sclerosis. Likewise, in most experimental models, early seizures occurring before the end of the sec... | ['Aging', 'Animals', 'Animals, Newborn', 'Cerebellar Cortex', 'Disease Models, Animal', 'Disease Susceptibility', 'Dose-Response Relationship, Drug', 'Electroencephalography', 'Excitatory Amino Acid Agonists', 'Female', 'GABA Antagonists', 'GABA-A Receptor Antagonists', 'Kainic Acid', 'Lithium', 'Male', 'Muscarinic Ago... | 12,350,394 | [['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['A08.186.211.132.810.428.200.212'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.687', 'G07.100.250'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.376.300', 'E01.370.405.245'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['D27.505.51... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preliminary investigation on Mgbede-20 oil-polluted site in Niger Delta, Nigeria. | Soil physicochemical properties (pH, electrical conductivity (EC), % moisture, total organic carbon (TOC), total organic matter (TOM)), total extractable hydrocarbon content (THC), and micronutrient (Mn, Fe, Cu, Zn) levels of the Mgbede-20 oil-impacted site in Niger Delta, Nigeria, were investigated. Both oil-impacted ... | ['Electric Conductivity', 'Hydrogen-Ion Concentration', 'Nigeria', 'Organic Chemicals', 'Petroleum', 'Soil Pollutants'] | 17,193,292 | [['G01.358.500.249.277'], ['G02.300'], ['Z01.058.290.190.565'], ['D02'], ['D20.345.630', 'N06.230.132.258.630'], ['D27.888.284.756']] | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Biocompatibility test of polyhydroxybutyrate on human cell line. | The human fibroblast MRC-5 cells incubated with PHB granules (TM) added at a final concentration of 4 mg/ml showed a time-course pattern of survival. The percentages of dead cells obtained were at the rate of 3.8% after 7 days, respectively. When the MRC-5 cells grown in different material, using the test concentration... | ['Cell Line', 'Cell Survival', 'Fibroblasts', 'Humans', 'Hydroxybutyrates', 'In Vitro Techniques', 'Materials Testing', 'Polymers'] | 15,468,838 | [['A11.251.210'], ['G04.346'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.081.114.937', 'D02.241.511.429', 'D10.251.400.143.781'], ['E05.481'], ['E05.570'], ['D05.750', 'D25.720', 'J01.637.051.720']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Correlation of histamine H1 receptor function and [3H]mepyramine binding in porcine tracheal tissue. | In order to validate the use of [3H]mepyramine as a radioligand to label airway histamine H1 receptors, the results of radioligand binding experiments using porcine tracheal tissue membranes were compared with the results of physiologic studies measuring histamine-induced trachealis muscle contraction. Close agreement ... | ['Aminopyridines', 'Animals', 'In Vitro Techniques', 'Models, Biological', 'Muscle Contraction', 'Muscle, Smooth', 'Pyrilamine', 'Receptors, Histamine', 'Receptors, Histamine H1', 'Swine', 'Time Factors', 'Trachea'] | 3,666,006 | [['D02.092.080', 'D03.383.725.050'], ['B01.050'], ['E05.481'], ['E05.599.395'], ['G11.427.494'], ['A02.633.570', 'A10.690.467'], ['D03.383.725.050.805'], ['D12.776.543.750.670.450', 'D12.776.543.750.720.480'], ['D12.776.543.750.670.450.300', 'D12.776.543.750.695.350', 'D12.776.543.750.720.480.300'], ['B01.050.150.900.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Contrast-enhanced magnetic resonance imaging estimation of altered capillary permeability in experimental mammary carcinomas after X-irradiation. | RATIONALE AND OBJECTIVES: Dynamic magnetic resonance imaging (MRI) enhanced with a macromolecular contrast medium, albumin-(Gd-DTPA)35, was used to detect changes in microvascular characteristics in R3230 mammary adenocarcinomas induced by x-irradiation.METHODS: Tumors were implanted in either flank in nine rats. One o... | ['Adenocarcinoma', 'Albumins', 'Animals', 'Capillaries', 'Capillary Permeability', 'Contrast Media', 'Endothelium, Vascular', 'Evans Blue', 'Gadolinium', 'Gadolinium DTPA', 'Magnetic Resonance Imaging', 'Mammary Neoplasms, Experimental', 'Neoplasm Transplantation', 'Organometallic Compounds', 'Pentetic Acid', 'Radiogra... | 7,890,512 | [['C04.557.470.200.025'], ['D12.776.034'], ['B01.050'], ['A07.015.461.165'], ['G03.143.330', 'G09.330.165'], ['D27.505.259.500', 'D27.720.259'], ['A07.015.700.500', 'A10.272.491.355'], ['D02.172.560', 'D02.455.426.559.847.638.555.400', 'D02.886.645.600.080.050.650.300', 'D04.615.638.555.400'], ['D01.268.558.362.484', '... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Growth on Congo red agar: possible means of identifying penicillin-resistant non-penicillinase-producing gonococci. | Exceptional strains of gonococci that grow on Congo red agar were found to be penicillin-resistant non-penicillinase producers. | ['Agar', 'Congo Red', 'Neisseria gonorrhoeae', 'Neisseria meningitidis', 'Penicillin Resistance', 'Penicillinase', 'Species Specificity'] | 411,807 | [['D09.698.360.041'], ['D02.455.426.559.847.638.555.300', 'D02.886.645.600.080.050.650.250', 'D04.615.638.555.300'], ['B03.440.400.425.550.550.474', 'B03.660.075.525.520.400'], ['B03.440.400.425.550.550.641', 'B03.660.075.525.520.500'], ['G06.099.225.500.600', 'G06.225.347.500.600', 'G07.690.773.984.269.347.500.600'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Free-edge stress analysis of functionally graded material layered biocomposite laminates. | A stress function based theory is proposed to obtain free-edge stress distributions for three-dimensional, orthotropic, linearly elastic rectangular biocomposite laminates with surface-bonded functionally graded materials (FGM). The assumed stress fields automatically satisfy the pointwise equilibrium equation, as well... | ['Biocompatible Materials', 'Materials Testing', 'Shear Strength', 'Stress, Mechanical'] | 25,942,808 | [['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E05.570'], ['G01.374.820'], ['G01.374.835']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Lower limb compartment syndrome associated with Lloyd-Davies/lithotomy position in colorectal surgery. | Lower limb compartment syndrome is a rare complication of surgical patients submitted to operation in the lithotomy/Lloyd-Davies position. The diagnosis and treatment of this feared complication should be promptly instituted otherwise the patient may have serious neuromuscular impairment, limb loss or even fatal outcom... | ['Aged', 'Compartment Syndromes', 'Digestive System Surgical Procedures', 'Humans', 'Leg', 'Male', 'Posture', 'Rectal Neoplasms'] | 15,011,839 | [['M01.060.116.100'], ['C05.651.180', 'C14.907.303'], ['E04.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['G11.427.695'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.469.860.180.500']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The transcriptional control machinery as well as the cell wall integrity and its regulation are involved in the detoxification of the organic solvent dimethyl sulfoxide in Saccharomyces cerevisiae. | In the present study, we have identified 339 dimethyl sulfoxide (DMSO)-sensitive and nine DMSO-tolerant gene mutations in Saccharomyces cerevisiae through a functional genomics approach. Twelve of these identified DMSO-sensitive mutations are of genes involved in the general control of gene expression mediated by the S... | ['Biotransformation', 'Cell Wall', 'Dimethyl Sulfoxide', 'Gene Expression Regulation, Fungal', 'Metabolic Networks and Pathways', 'Mutation', 'Saccharomyces cerevisiae', 'Solvents', 'Transcription, Genetic'] | 23,157,175 | [['G03.171', 'G03.787.225', 'G07.690.725.225'], ['A11.284.183'], ['D02.886.640.150'], ['G05.308.330'], ['G03.493'], ['G05.365.590'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D27.720.844'], ['G02.111.873', 'G05.297.700']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mother-child play and maltreatment: a longitudinal analysis of emerging social behavior from infancy to toddlerhood. | Mother-child play of maltreating and nonmaltreating families was analyzed when infants were 12 months old (Time 1), and 2 years old (Time 2), as a context to examine children's developing cognitive and social skills. At Time 1, infants from abusing families demonstrated less independent and more imitative behavior duri... | ['Child Abuse', 'Child Development', 'Child, Preschool', 'Cognition', 'Female', 'Humans', 'Infant', 'Longitudinal Studies', 'Male', 'Mother-Child Relations', 'Mothers', 'Multivariate Analysis', 'Neuropsychological Tests', 'Play and Playthings', 'Psychology, Child', 'Social Behavior', 'Statistics as Topic'] | 21,744,951 | [['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F01.829.263.370.290.170'], ['F... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Molecular cloning and developmental expression of foxP2 in zebrafish. | Forkhead domain transcription factors are a large gene family with multiple roles in development. FOXP2, a recently identified member of this family, has been shown to be critical for normal development of language in humans, but little is known of its broader function during nervous system development. We report here ... | ['Amino Acid Sequence', 'Animals', 'Cloning, Molecular', 'Forkhead Transcription Factors', 'Gene Expression Regulation, Developmental', 'Humans', 'Molecular Sequence Data', 'Phylogeny', 'RNA, Messenger', 'Sequence Alignment', 'Sequence Homology, Amino Acid', 'Telencephalon', 'Zebrafish', 'Zebrafish Proteins'] | 16,028,276 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.393.220'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['G05.308.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.544'], ['E05.393.751'], ['G02.111.810.200', 'G05.810.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Technosphere insulin: defining the role of Technosphere particles at the cellular level. | BACKGROUND: Technosphere Insulin (TI) is a novel inhalation powder for the treatment of diabetes mellitus. Technosphere Insulin delivers insulin with an ultra rapid pharmacokinetic profile that is distinctly different from all other insulin products but similar to natural insulin release. Such rapid absorption is often... | ['Administration, Inhalation', 'Biological Transport', 'Cell Line, Tumor', 'Cell Membrane Permeability', 'Cell Survival', 'Cytoskeleton', 'Decanoic Acids', 'Deoxycholic Acid', 'Fumarates', 'Humans', 'In Vitro Techniques', 'Insulin', 'Lung Neoplasms', 'Octoxynol', 'Piperazines', 'Powders', 'Tight Junctions'] | 20,144,294 | [['E02.319.267.050'], ['G03.143'], ['A11.251.210.190', 'A11.251.860.180'], ['G03.143.335', 'G04.175'], ['G04.346'], ['A11.284.430.214.190.750'], ['D10.251.175'], ['D04.210.500.105.225.272', 'D04.210.500.221.430.342'], ['D02.241.081.337.302'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['D06.472.699.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The influence of chronic pentroxifylline medication on ergometric and hemodynamic parameters in intermittent claudication (author's transl)]. | In an open clinical trial 14 patients with intermittent claudication caused by an obliteration of the femoral artery received 400 mg pentoxifylline 3 times daily over a period of 6 months. The walking distance, time to peak flow and calf ergometry showed a significant increase. Minor improvement of working hyperemia an... | ['Arterial Occlusive Diseases', 'Exercise Therapy', 'Femoral Artery', 'Humans', 'Hyperemia', 'Intermittent Claudication', 'Pentoxifylline', 'Theobromine'] | 556,192 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
FleQ coordinates flagellum-dependent and -independent motilities in Pseudomonas syringae pv. tomato DC3000. | Motility plays an essential role in bacterial fitness and colonization in the plant environment, since it favors nutrient acquisition and avoidance of toxic substances, successful competition with other microorganisms, the ability to locate the preferred hosts, access to optimal sites within them, and dispersal in the ... | ['Bacterial Proteins', 'Flagella', 'Locomotion', 'Lycopersicon esculentum', 'Mutation', 'Organelle Biogenesis', 'Plant Diseases', 'Pseudomonas syringae', 'Surface-Active Agents', 'Trans-Activators', 'Virulence'] | 26,296,726 | [['D12.776.097'], ['A11.284.180.290'], ['G07.568.500', 'G11.427.410.568'], ['B01.650.940.800.575.912.250.908.500.322'], ['G05.365.590'], ['G04.618', 'G16.645'], ['G15.610'], ['B03.440.400.425.625.625.770', 'B03.660.250.580.590.770'], ['D27.720.877'], ['D12.776.260.755', 'D12.776.930.900', 'D12.776.964.925.984'], ['G06.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Lack of donor organs as an argument for living donors?]. | In Germany more than 12,000 patients are presently waiting for an organ donation. Living donation makes sense for the long waiting time for a kidney, but it is not a permanent solution for the lack of organ donations. In the future topics which should be discussed are intensified public relations, a better family care ... | ['Cadaver', 'Germany', 'Humans', 'Immunosuppression', 'Living Donors', 'Patient Selection', 'Safety', 'Tissue Donors', 'Tissue and Organ Procurement', 'Transplantation Immunology', 'Waiting Lists'] | 20,683,566 | [['C23.550.260.224'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.450', 'E05.478.610'], ['M01.898.656'], ['E05.581.500.653', 'N04.590.731'], ['N06.850.135.060.075'], ['M01.898'], ['N02.421.911'], ['G12.875'], ['N04.452.095.738']] | ['Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Recent data concerning abnormal hemoglobins (author's transl)]. | The study of abnormal hemoglobins was oriented towards three criteria as a function of commonly encountered clinical problems : differentiation between frequent, relatively infrequent and exceptional hemoglobins ; systematic study of high-risk ethnic groups and isolated discoveries ; silent hemoglobinopathies and those... | ['Anemia, Hemolytic', 'Hemoglobin C', 'Hemoglobin E', 'Hemoglobin M', 'Hemoglobinopathies', 'Hemoglobins, Abnormal', 'Humans', 'Mutation', 'Oxyhemoglobins', 'Risk'] | 7,305,088 | [['C15.378.071.141'], ['D12.776.124.400.463.338', 'D12.776.422.316.762.426.338'], ['D12.776.124.400.463.375', 'D12.776.422.316.762.426.375'], ['D12.776.124.400.463.510', 'D12.776.422.316.762.426.510'], ['C15.378.420', 'C16.320.365'], ['D12.776.124.400.463', 'D12.776.422.316.762.426'], ['B01.050.150.900.649.313.988.400.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Differential knockdown of delta-opioid receptor subtypes in the rat brain by antisense oligodeoxynucleotides targeting mRNA. | Two antisense oligodeoxynucleotides (A-ODN), targeting delta-opioid receptor mRNA (DOR) and two mismatch ODN sequences (mODN) were continuously infused for 24 days into the lateral brain ventricles of Wistar rats. The density of delta-opioid receptors in rat brain homogenates was measured by saturation binding experime... | ['Animals', 'Brain', 'Corpus Striatum', 'Ligands', 'Male', 'Motor Activity', 'Oligodeoxyribonucleotides, Antisense', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Opioid, delta', 'Thionucleotides'] | 10,355,826 | [['B01.050'], ['A08.186.211'], ['A08.186.211.200.885.287.249.487'], ['D27.720.470.480'], ['F01.145.632', 'G11.427.410.698'], ['D13.150.200.640', 'D13.150.480.640', 'D13.444.308.150.640', 'D13.444.600.150.200.640', 'D13.444.600.150.640.640', 'D13.695.578.424.480.640', 'D27.720.470.530.600.150.200.640', 'D27.720.470.530.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A two-step enriched-nested PCR technique enhances sensitivity for detection of codon 12 K-ras mutations in pancreatic adenocarcinoma. | Mutations at codon 12 of the K-ras gene have been detected in pancreatic adenocarcinomas by a variety of techniques. A few of these techniques are very sensitive, identifying the mutations in 96-100% of cases. However, these sensitive techniques are labor intensive, utilizing multistep processing and radioactive materi... | ['Base Sequence', 'Carcinoma, Ductal, Breast', 'Codon', 'DNA Primers', 'DNA, Neoplasm', 'Genes, ras', 'Humans', 'Molecular Sequence Data', 'Pancreatic Neoplasms', 'Point Mutation', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'Proto-Oncogene Proteins p21(ras)', 'Sensitivity and Specificity'... | 9,211,488 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.425'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Combined kinetic studies and computational analysis on kojic acid analogous as tyrosinase inhibitors. | Tyrosinase is a key enzyme in melanin synthesis and widely distributed in plants and animals tissues. In mammals, this enzyme is related to pigment production, involved in wound healing, primary immune response and it can also contribute to catecholamines synthesis in the brain. Consequently, tyrosinase enzyme represen... | ['Catalytic Domain', 'Kinetics', 'Models, Molecular', 'Molecular Docking Simulation', 'Molecular Dynamics Simulation', 'Monophenol Monooxygenase', 'Protein Conformation', 'Pyrones'] | 25,004,069 | [['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['E05.599.595.249', 'L01.224.160.249'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D08.811.682.690.708.125.500'], ['G02.111.570.820.709'], ['D03.383.663.718']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ganglioside changes induced by tumor promoters in promotable JB6 mouse epidermal cells: antagonism by an antipromoter. | Since cell surface gangliosides have been implicated in the regulation of cell growth and differentiation and since tumor-promoting phorbol esters produce a number of membrane changes, the possibility was investigated that ganglioside changes may play a role in promotion of transformation in JB6 mouse epidermal cells. ... | ['Animals', 'Cell Division', 'Cell Line', 'Cell Transformation, Neoplastic', 'Epidermis', 'Gangliosides', 'Mice', 'Phorbols', 'Tetradecanoylphorbol Acetate', 'Time Factors', 'Tretinoin'] | 6,950,175 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A10.272.497', 'A17.815.250'], ['D09.400.410.420.025.475', 'D10.390.470.025.475', 'D10.570.877.360.025.475'], ['B01.050.150.900.649.313.992.635.505.500'], ['D02.455.849.2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment of locally advanced rectal cancer with external beam radiation, surgical resection, and intraoperative radiation therapy. | To try to improve the local control and survival of patients with locally advanced rectal cancer we have used a combination of high-dose pre-operative radiation therapy to 5,040 cGy followed by surgical resection and intraoperative electron beam radiation therapy (IORT) when there was visible or palpable residual disea... | ['Combined Modality Therapy', 'Humans', 'Intraoperative Care', 'Prognosis', 'Radiotherapy, High-Energy', 'Rectal Neoplasms'] | 2,498,239 | [['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.400'], ['E01.789'], ['E02.815.722'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.469.860.180.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Predicting adverse outcome with exercise SPECT technetium-99m sestamibi imaging in patients with suspected or known coronary artery disease. | The goal of this study was to determine the ability of exercise single-photon emission computed tomographic (SPECT) technetium-99m (Tc-99m) sestamibi imaging to predict adverse events in a population with a comparable distribution of men (n = 114) and women (n = 115). Consecutive patients referred for evaluation of che... | ['Adult', 'Aged', 'Coronary Disease', 'Death', 'Disease-Free Survival', 'Exercise Test', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Predictive Value of Tests', 'Technetium Tc 99m Sestamibi', 'Tomography, Emission-Computed, Single-Photon'] | 9,036,743 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.647.250', 'C14.907.585.250'], ['C23.550.260'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A Global lmmunological Observatory to meet a time of pandemics. | SARS-CoV-2 presents an unprecedented international challenge, but it will not be the last such threat. Here, we argue that the world needs to be much better prepared to rapidly detect, define and defeat future pandemics. We propose that a Global Immunological Observatory and associated developments in systems immunolog... | ['Animals', 'Anti-Infective Agents', 'COVID-19', 'Climate Change', 'Cohort Studies', 'Communicable Disease Control', 'Communicable Diseases, Emerging', 'Coronavirus Infections', 'Disaster Planning', 'Drug Development', 'Forecasting', 'Global Health', 'Humans', 'Interdisciplinary Communication', 'International Cooperati... | 32,510,329 | [['B01.050'], ['D27.505.954.122'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['G16.500.175.374'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N06.850.780.200'], ['C01.221.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Info... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Morphometric, molecular and ecological analyses of the parasites of the sharpsnout seabream Diplodus puntazzo Cetti (Sparidae) from the Spanish Mediterranean: implications for aquaculture. | One of the fish species with the highest potential for aquaculture is the sharpsnout seabream, Diplodus puntazzo Cetti. Among other aspects, the development of new fish cultures requires studies of potential pathogens that may compromise survival of the fish in captivity. Moreover, both cultured and wild fish can act a... | ['Animals', 'Aquaculture', 'Fish Diseases', 'Mediterranean Region', 'Parasites', 'Sea Bream', 'Spain', 'Trematoda'] | 24,299,967 | [['B01.050'], ['J01.040.168'], ['C22.362'], ['Z01.542.580'], ['B01.050.500.714'], ['B01.050.150.900.493.602.750'], ['Z01.542.846'], ['B01.050.500.500.736.715']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Six weeks of home enteral nutrition versus standard care after esophagectomy or total gastrectomy for cancer: study protocol for a randomized controlled trial. | BACKGROUND: Each year approximately 3000 patients in the United Kingdom undergo surgery for esophagogastric cancer. Jejunostomy feeding tubes, placed at the time of surgery for early postoperative nutrition, have been shown to have a positive impact on clinical outcomes in the short term. Whether feeding out of hospita... | ['Clinical Protocols', 'Cost-Benefit Analysis', 'England', 'Enteral Nutrition', 'Esophageal Neoplasms', 'Esophagectomy', 'Feasibility Studies', 'Gastrectomy', 'Health Care Costs', 'Home Care Services', 'Humans', 'Jejunostomy', 'Nutritional Status', 'Patient Readmission', 'Pilot Projects', 'Quality of Life', 'Research D... | 24,885,032 | [['E02.183', 'N05.715.360.330.125'], ['N03.219.151.125'], ['Z01.542.363.300'], ['E02.421.360', 'E02.642.500.360'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['E04.210.346'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E04... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Treatment of patients with severe burn injuries: the impact of schizophrenia. | Four patients treated in one ward of a psychiatric clinic were admitted to our burn unit within 2 months due to severe burn injuries. The patients showed signs of a self-mutilation epidemic. All four patients were female and the mean age was 28 years. The psychiatric diagnosis was schizophrenia in all patients (ICD 10:... | ['Adult', 'Burns', 'Case-Control Studies', 'Female', 'Humans', 'Imitative Behavior', 'Length of Stay', 'Male', 'Schizophrenia', 'Schizophrenic Psychology', 'Self-Injurious Behavior', 'Social Environment', 'Wound Healing'] | 12,543,045 | [['M01.060.116'], ['C26.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.510'], ['E02.760.400.480', 'N02.421.585.400.480'], ['F03.700.750'], ['F04.824'], ['F01.145.126.980'], ['I01.880.853.500'], ['G16.762.891']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Sorptive removal of odorous carbonyl gases by water. | In this study, the removal capacity of deionized water was investigated against five gaseous carbonyl compounds (i.e., acetaldehyde, propionaldehyde, butyraldehyde, valeraldehyde, and isovaleraldehyde) by means of the gas stripping method. To determine the trapping behavior of these odorants by water, gaseous working s... | ['Absorption', 'Aldehydes', 'Chromatography, High Pressure Liquid', 'Gases', 'Odorants', 'Spectrophotometry, Ultraviolet', 'Volatile Organic Compounds', 'Water'] | 20,364,239 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['D02.047'], ['E05.196.181.400.300'], ['D01.362'], ['G16.500.275.640', 'N06.230.480'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D02.974'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Lens thickness in western Nigeria. A comparative ultrasonic study in Negros and Danes. | A comparative ultrasonic, oculometric study was performed in negroes, West Nigeria (151 persons) and in caucasians, Denmark (88 persons). The negros have thinner lenses than caucasians, and overall ethnic difference of 0.12 mm was found. Male negroes have longer vitreous and axial lengths than male caucasians (VB 0.56 ... | ['Adult', 'African Continental Ancestry Group', 'Aged', 'Denmark', 'European Continental Ancestry Group', 'Eye', 'Humans', 'Lens, Crystalline', 'Male', 'Middle Aged', 'Nigeria', 'Ultrasonics'] | 4,036,555 | [['M01.060.116'], ['M01.686.508.100'], ['M01.060.116.100'], ['Z01.542.816.124'], ['M01.686.508.400'], ['A01.456.505.420', 'A09.371'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.060.500'], ['M01.060.116.630'], ['Z01.058.290.190.565'], ['H01.671.031.849']] | ['Named Groups [M]', 'Geographicals [Z]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 |
Laparoscopic bariatric surgery for morbid obesity: the first hundred cases in an Irish centre. | INTRODUCTION: This study evaluated outcomes for the first 100 bariatric surgical procedures in a single, publicly funded Irish centre.METHODS: This was a retrospective, chart-based study. Demographics and comorbidities of patients, peri- and post-operative outcomes and health benefits obtained by surgery were assessed.... | ['Adult', 'Aged', 'Anastomosis, Roux-en-Y', 'Female', 'Gastric Bypass', 'Gastroplasty', 'Humans', 'Ireland', 'Laparoscopy', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Postoperative Period', 'Quality of Life', 'Retrospective Studies', 'Treatment Outcome', 'Weight Loss', 'Young Adult'] | 19,714,393 | [['M01.060.116'], ['M01.060.116.100'], ['E04.035.070', 'E04.210.070'], ['E02.650.500.062.249', 'E04.035.398.385', 'E04.062.249', 'E04.210.457.430'], ['E02.650.500.062.750', 'E04.062.750', 'E04.210.485'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.467', 'Z01.639.587'], ['E01.370.388.250.520', 'E04.502.25... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online. | Worldwide, the DNA mismatch repair genes MSH2 and MLH1 account for a major share and almost equal proportions of hereditary nonpolyposis colorectal cancer (HNPCC). Furthermore, the predisposing mutation usually varies from kindred to kindred. In this study, we screen 29 verified or putative HNPCC kindreds from Finland ... | ['Adaptor Proteins, Signal Transducing', 'Base Pair Mismatch', 'Carrier Proteins', 'Colorectal Neoplasms, Hereditary Nonpolyposis', 'DNA Repair', 'DNA-Binding Proteins', 'Humans', 'MutL Protein Homolog 1', 'MutS Homolog 2 Protein', 'Mutation', 'Neoplasm Proteins', 'Nuclear Proteins', 'Proto-Oncogene Proteins'] | 10,200,055 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G05.365.590.060'], ['D12.776.157'], ['C04.588.274.476.411.307.190', 'C04.700.250', 'C06.301.371.411.307.190', 'C06.405.249.411.307.190', 'C06.405.469.158.356.190', 'C06.405.469.491.307.190', 'C16.320.700.250', 'C18.452.284.255'], ['G02.111.222', 'G05.219'], ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Management of malignant melanoma: a retrospective analysis of 182 patients. | The records of 182 patients, referred to the Regional Radiotherapy Centre, Newcastle upon Tyne between January 1975 and December 1980, have been reviewed to evaluate the results of different modes of treatment. Fifty-two patients were managed for Stage 1, 83 for Stage 2 and 47 for Stage 3 disease. Fifty-seven patients ... | ['Adolescent', 'Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Bleomycin', 'Dacarbazine', 'Female', 'Humans', 'Lomustine', 'Lymphatic Metastasis', 'Male', 'Melanoma', 'Middle Aged', 'Retrospective Studies', 'Skin Neoplasms'] | 6,199,154 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D09.400.420.110', 'D12.644.233.110'], ['D02.925.200', 'D03.383.129.308.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.950.594.440', 'D02.654.692.440'], ['C04.697.650.560', 'C23.550.727... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Primary retroperitoneal mucinous cystadenocarcinoma with mural nodules: a case report and literature review. | A primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is an extremely rare lesion. To date, only 49 cases have been reported. The presence of mural nodules in a PRMC may indicate a worse prognosis. We report the case of a 40-year-old Japanese woman with a PRMC with mural nodules. Microscopic examination revealed... | ['Adult', 'Cystadenocarcinoma, Mucinous', 'Female', 'Humans', 'Keratins', 'Prognosis', 'Retroperitoneal Neoplasms', 'Sarcoma', 'Vimentin'] | 21,927,830 | [['M01.060.116'], ['C04.557.470.200.025.480.225', 'C04.557.470.590.480.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.078.593.450', 'D12.776.220.475.450', 'D12.776.860.607'], ['E01.789'], ['C04.588.033.731'], ['C04.557.450.795'], ['D05.750.078.593.900', 'D12.776.220.475.900']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Trochanteric fragility fractures : Treatment using the cement-augmented proximal femoral nail antirotation. | OBJECTIVE: Use of standardized cement augmentation of the proximal femur nail antirotation (PFNA) for the treatment of trochanteric fragility fractures, which are associated with high morbidity and mortality, to achieve safer conditions for immediate full weight-bearing and mobilization, thus, improving preservation of... | ['Aged', 'Aged, 80 and over', 'Bone Cements', 'Bone Nails', 'Combined Modality Therapy', 'Female', 'Fracture Fixation, Intramedullary', 'Hip Fractures', 'Humans', 'Male', 'Osteoporotic Fractures', 'Polymethyl Methacrylate', 'Range of Motion, Articular', 'Reconstructive Surgical Procedures', 'Treatment Outcome'] | 27,245,659 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D05.750.716.822.300', 'D25.720.716.822.300', 'D27.720.102.158', 'J01.637.051.720.716.822.300'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['E02.186'], ['E04.555.300.300.300'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['B01.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Effect of non-depolarizing muscle relaxants on autonomic nervous system activity--assessment by heart rate variability analysis]. | We investigated the effect of d-tubocurarine (d-Tc), pancuronium (PAN), vecuronium (VEC), and rocuronium (ROC) on the autonomic nervous system in cats by measuring changes in the invasive mean arterial pressure (MAP), heart rate (HR), and heart rate variability following four administrations of each drug at 2.ED95. Hea... | ['Animals', 'Autonomic Nervous System', 'Blood Pressure', 'Cats', 'Dose-Response Relationship, Drug', 'Heart', 'Heart Rate', 'Neuromuscular Nondepolarizing Agents', 'Pancuronium', 'Tubocurarine'] | 10,658,407 | [['B01.050'], ['A08.800.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G07.690.773.875', 'G07.690.936.500'], ['A07.541'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D27.505.696.663.700.710.575'], ['D04.210.500.054.040.685'], ['D02.092.877.922', 'D02.675.276.922'... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Pleomorphic carcinoma of the pancreas--report of 3 cases]. | The incidence of pleomorphic carcinoma of the pancreas is low. In 34 cases of non-endocrinic cancer of the pancreas detected pathologically by operation and autopsy in our hospital from 1961 to 1984, 3 were pleomorphic carcinoma, comprising 8.8%. In histology, the tumor was clearly characterized by the bizarre uninucle... | ['Adult', 'Carcinoma', 'Diagnosis, Differential', 'Humans', 'Male', 'Middle Aged', 'Pancreatic Neoplasms'] | 3,743,349 | [['M01.060.116'], ['C04.557.470.200'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Electrophysiological differences of the spontaneous onset of paroxysmal and persistent atrial fibrillation. | BACKGROUND: Information about the spatiotemporal organization of atrial activity at the onset of atrial fibrillation (AF) is still limited.METHODS: AF mapping was performed in 30 patients with AF (mean age 53 +/- 9 years, 26 males) by deploying a noncontact mapping balloon in the left atrium (LA). Twenty-four patients ... | ['Acute Disease', 'Adult', 'Atrial Fibrillation', 'Chronic Disease', 'Electrocardiography', 'Female', 'Heart Conduction System', 'Heart Rate', 'Humans', 'Male', 'Middle Aged'] | 17,367,348 | [['C23.550.291.125'], ['M01.060.116'], ['C14.280.067.198', 'C23.550.073.198'], ['C23.550.291.500'], ['E01.370.370.380.240', 'E01.370.405.240'], ['A07.541.409'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Crohn's disease and lichen nitidus: a case report and comparison of common histopathologic features. | We describe a 54-year-old black woman with Crohn's disease, who developed lichen nitidus, the third report of a patient with both diseases. The rarity of these diseases individually and the histopathologic features in common imply that the two diseases are linked. Multinucleated giant cells, a common finding in the les... | ['Back', 'Comorbidity', 'Crohn Disease', 'Diagnosis, Differential', 'Female', 'Giant Cells', 'Humans', 'Lichen Nitidus', 'Middle Aged'] | 11,720,321 | [['A01.923.176'], ['N05.715.350.225', 'N06.850.490.687'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['E01.171'], ['A11.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.859.475.545'], ['M01.060.116.630']] | ['Anatomy [A]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Metabolic equivalent of exercise stress test explained by six-minute walk test in post coronary artery bypass graft and post percutaneous coronary intervention patients. | OBJECTIVE: To investigate the relationship among metabolic equivalents of an exercise stress test (METs of EST), demographic parameters (age, body weight, height, BMI), peak oxygen consumption (VO(2) peak), and six-minute walk distances (6MWD) determined from a six-minute walk test (6MWT).MATERIAL AND METHOD: Exercise ... | ['Body Weights and Measures', 'Coronary Artery Bypass', 'Exercise Test', 'Humans', 'Metabolic Equivalent', 'Middle Aged', 'Oxygen Consumption', 'Percutaneous Coronary Intervention', 'Walking'] | 25,141,519 | [['E01.370.600.115.100', 'E05.041.124', 'G07.100.100'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.600.337', 'G03.680.365'], ['M01.060.116.630'], ['G03.680'], ['E04.100.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Quality indicators for out-of-hospital emergency medical services: the paramedics' perspective. | OBJECTIVE: Out-of-hospital emergency medical services (EMS) need relevant and measurable indicators of quality. Those front-line workers who provide service directly to the customer are integral to the process of defining quality. The authors' objective was to obtain from paramedics, the front-line workers in the EMS s... | ['Attitude of Health Personnel', 'Emergency Medical Services', 'Emergency Medical Technicians', 'Focus Groups', 'Humans', 'Pennsylvania', 'Quality Indicators, Health Care', 'Total Quality Management', 'Urban Health'] | 9,709,316 | [['F01.100.050', 'N05.300.100'], ['N02.421.297'], ['M01.526.373.250', 'M01.526.485.067.150', 'N02.360.067.150'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.075.550', 'Z01.107.567.875.350.550', 'Z01.107.567.875.500.550'], ['N04.76... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Implantation reduces the negative effects of bio-logging devices on birds. | Animal-borne logging or telemetry devices are widely used for measurements of physiological and movement data from free-living animals. For such measurements to be relevant, however, it is essential that the devices themselves do not affect the data of interest. A recent meta-analysis reported an overall negative effec... | ['Animals', 'Birds', 'Confidence Intervals', 'Prostheses and Implants', 'Sample Size', 'Telemetry'] | 23,125,345 | [['B01.050'], ['B01.050.150.900.248'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['E07.695'], ['E05.318.370.762', 'E05.581.500.902', 'N05.715.360.325.692', 'N06.850.520.445.762'], ['E01.370.520.750', 'E05.925', 'L01.178.847.675']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Differences in genetic population structures of Plasmodium falciparum isolates from patients along Thai-Myanmar border with severe or uncomplicated malaria. | BACKGROUND: There have been many reports on the population genetic structures of Plasmodium falciparum from different endemic regions, but few studies have examined the characteristics of isolates from patients with different clinical outcomes. The population genetic structures of P. falciparum isolates from patients w... | ['Adolescent', 'Adult', 'Animals', 'DNA, Protozoan', 'Female', 'Gene Frequency', 'Genotype', 'Humans', 'Malaria, Falciparum', 'Male', 'Microsatellite Repeats', 'Middle Aged', 'Myanmar', 'Plasmodium falciparum', 'Thailand'] | 18,937,873 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['D13.444.308.442'], ['G05.330'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530.650', 'C01.920.875.650'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['M01.060.116.630'], ['Z01.252.145.570'], ['B... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Importance of non-genetic mechanisms in carcinogenicity. | Integration of all this data suggests that the tumors reported by Hiraga and Fujii are related to the cytotoxicity induced in bladder epithelial tissue when primary metabolic pathways are overloaded by administration of high doses of SOPP . However, this appears to be a SECONDARY consequence of toxicity, rather than an... | ['Animals', 'Biphenyl Compounds', 'DNA', 'DNA Repair', 'DNA Replication', 'Humans', 'Kinetics', 'Male', 'Methylation', 'Neoplasms', 'Oncogenes', 'Oxygen', 'Rats', 'Urinary Bladder Neoplasms'] | 6,677,453 | [['B01.050'], ['D02.455.426.559.389.185'], ['D13.444.308'], ['G02.111.222', 'G05.219'], ['G02.111.225', 'G05.226'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538'], ['C04'], ['G05.360.340.024.340.375.500'], ['D01.268.185.550', 'D01.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
"Bow-tie" mitral valve repair: an adjuvant technique for ischemic mitral regurgitation. | BACKGROUND: Current techniques of mitral valve repair rely on decreasing valve area to increase leaflet apposition, but fail to address subvalvular dysfunction. A novel repair has been introduced with partial left ventriculectomy, which apposes the anterior leaflet to a corresponding point on the posterior leaflet crea... | ['Adult', 'Aged', 'Angina Pectoris', 'Female', 'Heart Ventricles', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Mitral Valve', 'Mitral Valve Insufficiency', 'Stroke Volume', 'Ventricular Dysfunction, Left'] | 9,875,764 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['M01.060.116.630'], ['A07.541.510.507'], ['C14.280.484.461'], ['E01.370.370.380.150.700', 'G09.330.380.124.882'], ['C14.280.945.900']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dual-Channel Surface Plasmon Resonance for Quantification of ApoE Gene and Genotype Discrimination in Unamplified Genomic DNA Extracts. | Identification of gene variation is of great importance for attaining information related to disease susceptibility. A highly sensitive and specific surface plasmon resonance (SPR) method for quantification of the apoE gene and genotype discrimination was demonstrated. The complementary sequences with the specific reco... | ['Alleles', 'Apolipoproteins E', 'Base Pair Mismatch', 'DNA', 'DNA Probes', 'Deoxyribonucleases, Type II Site-Specific', 'Genotyping Techniques', 'Humans', 'Nucleic Acid Hybridization', 'Proof of Concept Study', 'Surface Plasmon Resonance'] | 30,350,593 | [['G05.360.340.024.340.030'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['G05.365.590.060'], ['D13.444.308'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['E05.393.442']... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Functional connections in the human temporal lobe. I. Analysis of limbic system pathways using neuronal responses evoked by electrical stimulation. | Connections in the human mesial temporal lobe were investigated using brief, single pulses of electrical stimulation to evoke field potential responses in limbic structures of 74 epileptic patients. Eight specific areas within these structures were stereotactically targeted for study, including amygdala, entorhinal cor... | ['Action Potentials', 'Adolescent', 'Adult', 'Amygdala', 'Electric Stimulation', 'Electrodes, Implanted', 'Electroencephalography', 'Epilepsy', 'Evoked Potentials', 'Female', 'Hippocampus', 'Humans', 'Limbic System', 'Male', 'Neural Conduction', 'Neural Pathways', 'Neurons', 'Pyramidal Tracts', 'Temporal Lobe'] | 2,286,232 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.057'], ['M01.060.116'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['E05.723.402'], ['E07.305.250.319', 'E07.695.202'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['G07.265.216.500', 'G11.561.200.500'], ['A08.186.211.18... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Anti TNF-á (infliximab) treatment for intravenous immunoglobulin (IVIG) resistance patients with acute Kawasaki disease the effects of anticytokine therapy]. | Among the patients with acute Kawasaki disease treated with intravenous immunoglobulin (IVIG), 10-20 % demonstrate resistance or incomplete effects. Cardiac complication such as the coronary arterial aneurysm is frequent in these patients. For patients with IVIG-resistance, we have surveyed the efficacy and safety of a... | ['Acute Disease', 'Antibodies, Monoclonal', 'Drug Resistance', 'Humans', 'Immunoglobulins, Intravenous', 'Infliximab', 'Mucocutaneous Lymph Node Syndrome', 'Tumor Necrosis Factor-alpha'] | 25,518,416 | [['C23.550.291.125'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G07.690.773.984'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393.536', 'D12.776.124.486.485.114.632', 'D12.776.124.790.651.114.632', 'D12.776.377.715.548.114.632'],... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Case report: Abomasal involvement in bovine diaphragmatic hernia and surgical management. | Two rare cases of internal herenia in bovines (Bubalus bubalis), in which reticulum and abomasum had herniated into the thoracic cavity, were successfully treated. Involvement of abomasum did not exhibit any additional symptoms other than those commonly observed in cases where only reticulum is herniated. The term diap... | ['Abomasum', 'Animals', 'Cattle', 'Cattle Diseases', 'Female', 'Hernia, Diaphragmatic', 'Pregnancy'] | 761,155 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Staphylococcus aureus modulates the activity of acetyl-Coenzyme A synthetase (Acs) by sirtuin-dependent reversible lysine acetylation. | Lysine acylation is a posttranslational modification used by cells of all domains of life to modulate cellular processes in response to metabolic stress. The paradigm for the role of lysine acylation in metabolism is the acetyl-coenzyme A synthetase (Acs) enzyme. In prokaryotic and eukaryotic cells alike, Acs activity ... | ['Acetate-CoA Ligase', 'Acetylation', 'Amino Acid Motifs', 'Bacterial Proteins', 'Lysine', 'Sirtuins', 'Staphylococcus aureus', 'Succinic Acid'] | 31,099,918 | [['D08.811.464.267.500.200'], ['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D12.776.097'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['D08.811.277.087.520.200.650', 'D08.811.913.400.725.115.961', 'D12.776.476.900'], ['B03.300.39... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cloning and characterization of a female genital complex cDNA from the liver fluke Fasciola hepatica. | A cDNA clone whose RNA is abundant in the female genital complex of the liver fluke Fasciola hepatica has been isolated from a cDNA library in lambda gt10 by differential screening. The pattern of expression in different fluke tissues and at different stages of miracidium formation suggests that this gene is expressed ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA', 'Egg Proteins', 'Egg Shell', 'Fasciola hepatica', 'Female', 'Genes', 'Sequence Homology, Nucleic Acid', 'Trematoda'] | 3,470,798 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308'], ['D12.776.290'], ['A13.316'], ['B01.050.500.500.736.715.408.380.420'], ['G05.360.340.024.340'], ['G02.111.810.550', 'G05.810.550'], ['B01.050.500.500.736.715']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Naturally occurring and induced ganglion cell death. A retinal whole-mount autoradiographic study in Xenopus. | The retina in frogs grows continuously throughout the whole life of the animal by the addition of rings of cells at the ciliary margin. Naturally occurring neuron death cannot, consequently, be established by counting surviving neurons. A new approach, retinal whole-mount auto-radiography was introduced in this study t... | ['Animals', 'Autoradiography', 'Cell Count', 'Cell Survival', 'Larva', 'Nerve Crush', 'Retina', 'Retinal Ganglion Cells', 'Thymidine', 'Xenopus laevis'] | 3,706,775 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.346'], ['B05.500.500', 'G07.345.500.550.500.500'], ['E04.525.210.560'], ['A09.371.729'], ['A08.675.650.850.875', 'A09.371.729.831.875', 'A11.671.650.850.875'], ['D03.383.7... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early-onset drug-induced parkinsonism after exposure to offenders implies nigrostriatal dopaminergic dysfunction. | OBJECTIVES: The onset of parkinsonism in patients with drug-induced parkinsonism (DIP) exhibits extensive individual variability following exposure to offending drugs. We investigated whether the individual variations in the onset time of parkinsonism reflected the underlying subtle dopaminergic dysfunction in DIP.METH... | ['Aged', 'Anticonvulsants', 'Antiemetics', 'Antipsychotic Agents', 'Calcium Channel Blockers', 'Case-Control Studies', 'Caudate Nucleus', 'Corpus Striatum', 'Deprescriptions', 'Dopamine Plasma Membrane Transport Proteins', 'Female', 'Fluorine Radioisotopes', 'Humans', 'Male', 'Middle Aged', 'Neostriatum', 'Parkinsonian... | 28,912,301 | [['M01.060.116.100'], ['D27.505.954.427.080'], ['D27.505.696.663.050.030', 'D27.505.954.427.095', 'D27.505.954.483.200'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['E05.318.372.500.500', 'N05.715.360... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Environmental effects on skeletal versus dental development II: further testing of a basic assumption in human osteological research. | This study further tests the general assumption that skeletal development is more sensitive to socioeconomic factors than dental development in a sample of modern immature Portuguese skeletons (N = 41) of known sex, age, and socioeconomic background. Skeletal development was assessed from skeletal maturation of the kne... | ['Adolescent', 'Age Determination by Skeleton', 'Age Determination by Teeth', 'Anthropology, Physical', 'Child', 'Child, Preschool', 'Databases, Factual', 'Female', 'Femur', 'Humans', 'Infant', 'Knee Joint', 'Male', 'Malnutrition', 'Social Class', 'Statistics, Nonparametric', 'Tibia', 'Tooth', 'Young Adult'] | 21,302,272 | [['M01.060.057'], ['E01.370.049', 'E01.370.350.700.050'], ['E01.370.350.700.720.050', 'E01.370.600.024.650.500', 'E05.041.650.500', 'E06.342.764.142', 'E06.623.500'], ['I01.076.368'], ['M01.060.406'], ['M01.060.406.448'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['A02.835.232.043.150'], ['B01.050.150.900.649... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila. | Genes of the achaete-scute complex (ASC) participate in the formation of the central nervous system in the Drosophila embryo. Previous genetic analyses have indicated that lethal of scute (l'sc) is the most important gene of the complex in that process. We have obtained antibodies against the l'sc protein to study the ... | ['Animals', 'Blastoderm', 'Central Nervous System', 'Drosophila', 'Gene Expression', 'Genes', 'Microscopy, Electron', 'Phenotype', 'Proteins'] | 1,782,859 | [['B01.050'], ['A16.331.024'], ['A08.186'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['G05.297'], ['G05.360.340.024.340'], ['E01.370.350.515.402', 'E05.595.402'], ['G05.695'], ['D12.776']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Age Is Associated With Pain Experience and Opioid Use After Head and Neck Free Flap Reconstruction. | OBJECTIVES: To describe pain experience and opioid use after major head and neck reconstructive surgery.STUDY DESIGN: Retrospective cohort study.METHODS: Patients undergoing major head and neck surgery with microvascular free tissue transfer (free flaps) at a tertiary academic center were included. Pain scores (0-10) a... | ['Adolescent', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Analgesics, Opioid', 'Female', 'Free Tissue Flaps', 'Head and Neck Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Minnesota', 'Pain Measurement', 'Pain, Postoperative', 'Retrospective Studies', 'Risk Factors'] | 32,413,165 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['A10.850.710.500', 'E07.862.710.500'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Neural infiltration in benign gallbladder lesions. Description of a case]. | Neural infiltration is considered a very useful marker of malignancy in the biliary tract. Aim of this study is to report a case of benign epithelium of the gallbladder with neural infiltration and to review the literature. | ['Adenocarcinoma', 'Aged', 'Autonomic Pathways', 'Cholecystectomy, Laparoscopic', 'Cholecystitis', 'Cholelithiasis', 'Diagnosis, Differential', 'Epithelial Cells', 'Gallbladder', 'Gallbladder Neoplasms', 'Humans', 'Hyperplasia', 'Hypertrophy', 'Lymph Nodes', 'Male'] | 9,628,979 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['A08.800.050.050', 'A08.800.800.060'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['C06.130.564.263'], ['C06.130.409'], ['E01.171'], ['A11.436'], ['A03.159.439'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['B01.050.150.900.649.... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effect of salidroside on rat bone marrow mesenchymal stem cells differentiation into cholinergic nerve cells]. | OBJECTIVE: To investigate the effect of salidroside on rat bone marrow mesenchymal stem cells (BMSCs) differentiation into the cholinergic nerve cells, so as to provide the theory basis of the combination of salidroside and stem cells for clinical therapy of nervous system diseases.METHODS: BMSCs were isolated from 2 W... | ['Animals', 'Bone Marrow Cells', 'Cell Differentiation', 'Cells, Cultured', 'Cholinergic Neurons', 'Glucosides', 'Mesenchymal Stem Cells', 'Phenols', 'Rats', 'Rats, Wistar'] | 22,403,877 | [['B01.050'], ['A11.148', 'A15.378.316'], ['G04.152'], ['A11.251'], ['A08.675.127', 'A11.671.188'], ['D09.408.348'], ['A11.329.830.500', 'A11.872.590.500'], ['D02.455.426.559.389.657'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immobilization-induced cartilage degeneration mediated through expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and chondromodulin-I. | Immobilization results in thinning of the articular cartilage and cartilage degeneration, although the exact mechanisms are not clear yet. Hypoxia is thought to contribute to the degeneration of articular cartilage. We investigated the roles of hypoxia inducible factor (HIF)-1alpha, vascular endothelial growth factor (... | ['Analysis of Variance', 'Animals', 'Cartilage Diseases', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Immobilization', 'Immunohistochemistry', 'Intercellular Signaling Peptides and Proteins', 'Male', 'Membrane Proteins', 'Rats', 'Rats, Wistar', 'Tarsus, Animal', 'Vascular Endothelial Growth Factor A'] | 19,212,851 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['C05.182', 'C17.300.182'], ['D12.776.260.103.625.750', 'D12.776.930.125.625.750'], ['E05.472'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Epidemiology of first-episode psychosis: illustrating the challenges across diagnostic boundaries through the Cavan-Monaghan study at 8 years. | The epidemiology of first-episode psychosis is poorly understood because of the paucity of systematic studies, yet it constitutes the fundamental basis for understanding the disorder and the foundations on which clinical, biological, therapeutic, and long-term outcome studies are built. A particular need is to clarify ... | ['Adolescent', 'Adult', 'Aged', 'Diagnosis, Differential', 'Epidemiologic Studies', 'Ethnic Groups', 'Female', 'Humans', 'Ireland', 'Male', 'Middle Aged', 'Prevalence', 'Prospective Studies', 'Psychotic Disorders', 'Research Design', 'Social Class', 'Terminology as Topic'] | 15,944,446 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.171'], ['E05.318.372.500', 'N05.715.360.330.500', 'N06.850.520.450.500'], ['M01.686.754', 'N01.224.317'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.467', 'Z01.639.587'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.935.597.750',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation. | The role of transcription termination process for gene expression regulation is poorly understood. Either a multicopy supply of the rof gene or bicyclomycin, both of which inhibit the transcription termination Rho factor, suppressed the increased sensitivity to oxidative stress of the rifampicin-resistant rpoB mutation... | ['DNA-Directed RNA Polymerases', 'Drug Resistance, Bacterial', 'Escherichia coli', 'Mutation', 'Oxidative Stress', 'Rho Factor', 'Rifampin', 'Staphylococcus aureus', 'Time Factors', 'Transcription, Genetic'] | 15,836,776 | [['D08.811.913.696.445.735.270'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.365.590'], ['G03.673', 'G07.775.750'], ['D12.776.930.785'], ['D03.633.400.811.700', 'D04.345.295.750.700'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antibacterial activities of OPC-17116, ofloxacin, and ciprofloxacin against 200 isolates of Neisseria gonorrhoeae. | OPC-17116 is a new fluoroquinolone with potent activity against aerobic and anaerobic organisms. We evaluated the susceptibilities of 200 clinical gonococcal isolates including organisms with plasmid and chromosomally mediated resistance to beta-lactams and tetracycline. The antibiotics studied included OPC-17116, oflo... | ['Anti-Infective Agents', 'Ciprofloxacin', 'Fluoroquinolones', 'Microbial Sensitivity Tests', 'Neisseria gonorrhoeae', 'Ofloxacin', 'Penicillin Resistance', 'Piperazines', 'Quinolones', 'Tetracycline Resistance'] | 8,257,153 | [['D27.505.954.122'], ['D03.633.100.810.835.322.186'], ['D03.633.100.810.835.322'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B03.440.400.425.550.550.474', 'B03.660.075.525.520.400'], ['D03.633.100.810.835.322.500'], ['G06.099.225.500.600', 'G06.225.347.500.600', 'G07.690.773.984.269.347.500.600'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Challenged but not threatened: Managing health in advanced age. | In this paper we reflect on discussions with people of advanced age in ?otearoa New Zealand, and draw on theoretical frameworks of resilience and place in old age, to explore insights about the ways older people maintain quality of life and health. Twenty community-dwelling people of advanced age (85+) were recruited i... | ['Adaptation, Psychological', 'Aged, 80 and over', 'Aging', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'New Zealand', 'Qualitative Research', 'Resilience, Psychological'] | 29,941,204 | [['F01.058'], ['M01.060.116.100.080'], ['G07.345.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['Z01.639.760.747', 'Z01.678.100.747'], ['H01.770.644.241.850'], ['F02.940']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring. | Early-life adversity is a major risk factor for the development of diseases later in life. Maternal protein restriction (MPR) is associated with morbidities in offspring affecting multiple organs, but its impact on the gastrointestinal (GI) tract remains poorly studied. Using a rat model, we examined the consequences o... | ['Animals', 'Autophagy', 'Body Size', 'Body Weight', 'Choline O-Acetyltransferase', 'Colon', 'Corticosterone', 'Dietary Proteins', 'Enteric Nervous System', 'Female', 'Gastrointestinal Tract', 'Intestinal Absorption', 'Maternal Exposure', 'Models, Animal', 'Neurons', 'Nitric Oxide Synthase Type I', 'Pregnancy', 'Prenat... | 30,067,379 | [['B01.050'], ['G04.011'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D08.811.913.050.134.180'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D04.210.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
High-throughput and longitudinal analysis of aging and senescent decline in Caenorhabditis elegans. | Caenorhabditis elegans is becoming a multipurpose tool for genetic and chemical compound screening approaches aiming to identify and target the molecular mechanisms underlying senescent decline, aging, and associated pathologies. In this chapter, we describe specialized methods that have been developed to facilitate su... | ['Aging', 'Animals', 'Caenorhabditis elegans', 'Culture Media', 'Microfluidic Analytical Techniques', 'Sterilization', 'Stress, Physiological', 'Survival Analysis'] | 23,296,679 | [['G07.345.124'], ['B01.050'], ['B01.050.500.500.294.400.875.660.250.250'], ['D27.720.470.305', 'E07.206'], ['E05.588.465'], ['N06.850.780.200.450.850'], ['G07.775'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cyclodiode laser therapy for painful, blind glaucomatous eyes. | AIMS: To determine the ability of cyclodiode laser treatment to relieve discomfort in painful blind glaucomatous eyes.METHODS: 30 eyes underwent cyclodiode to reduce intraocular pressure (IOP) and relieve pain. Patients graded their pre-cyclodiode and post-cyclodiode pain.RESULTS: After a minimum follow up of 6 months,... | ['Aged', 'Blindness', 'Confidence Intervals', 'Glaucoma', 'Humans', 'Laser Therapy', 'Linear Models', 'Longitudinal Studies', 'Pain', 'Pain Measurement', 'Postoperative Complications', 'Prospective Studies', 'Tonometry, Ocular', 'Treatment Outcome'] | 11,264,140 | [['M01.060.116.100'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Serum and pancreatic immunoreactive insulin (IRI) and proinsulin-like component (PLC), serum IRI and PLC response to different stimuli in normal subjects and organic hyperinsulinism. | The serum levels of total immunoreactive insulin (IRI) and proinsulin-like component (PLC) in the fasting state and following the administration of insulin secretagogues in 5 patients with organic hyperinsulinism and age and sex matched normal subjects are reported. Diagnosis of organic hyperinsulinism could be establi... | ['Adenoma, Islet Cell', 'Adolescent', 'Adult', 'Antibody Formation', 'Antigens', 'Blood Glucose', 'Female', 'Glucagon', 'Glucose Tolerance Test', 'Humans', 'Hyperinsulinism', 'Insulin', 'Male', 'Middle Aged', 'Pancreas', 'Pancreatic Neoplasms', 'Proinsulin', 'Tolbutamide'] | 181,932 | [['C04.557.470.035.100', 'C04.588.274.761.249', 'C04.588.322.475.249', 'C06.301.761.249', 'C06.689.667.249', 'C19.344.421.249'], ['M01.060.057'], ['M01.060.116'], ['G12.450.050.370.250'], ['D23.050'], ['D09.947.875.359.448.500'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['E01.370.225.124.100.355', 'E01.3... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Technique and pitfalls of retrograde continuous warm blood cardioplegia. | The recent development of normothermic myocardial preservation and systemic perfusion during bypass has questioned the fundamental need for hypothermia during cardiac operations. The antegrade technique of almost continuous perfusion by the aortic root and vein grafts has been supplemented by continuous normothermic bl... | ['Blood', 'Heart Arrest, Induced', 'Hot Temperature', 'Humans'] | 2,039,304 | [['A12.207.152', 'A15.145'], ['E04.100.376.374', 'E04.928.220.360'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette's disorder: a pilot randomised controlled trial with long-term follow-up. | OBJECTIVE: Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided ... | ['Adolescent', 'Behavior Therapy', 'Child', 'Cost-Benefit Analysis', 'Female', 'Follow-Up Studies', 'Humans', 'Internet', 'Logistic Models', 'Male', 'Parents', 'Personal Satisfaction', 'Pilot Projects', 'Quality of Life', 'Single-Blind Method', 'Sweden', 'Tourette Syndrome', 'Treatment Outcome'] | 30,772,854 | [['M01.060.057'], ['F04.754.137'], ['M01.060.406'], ['N03.219.151.125'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Conundrum of elevated HbA1C and hypoglycemia-a rare cause. | A white diabetic patient on insulin therapy presented with recurrent hypoglycemia despite very high glycosylated hemoglobin (HbA1c) values. Hemoglobin (Hb) variants, chemically modified Hb, and abnormalities of red cell turnover cause errors in HbA1c measurement. Widely prevalent Hb variants affecting HbA1c estimation ... | ['Chromatography, High Pressure Liquid', 'Fetal Hemoglobin', 'Glycated Hemoglobin A', 'Hemoglobin E', 'Hemoglobin J', 'Humans', 'Hypoglycemia', 'Male', 'Middle Aged'] | 18,480,656 | [['E05.196.181.400.300'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['D12.776.124.400.463.375', 'D12.776.422.316.762.426.375'], ['D12.776.124.400.463.480', 'D12.776.422.316.762.426.480'], ['B01.050.150.900.649.31... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer. | Multigene assays have been developed and validated to determine the prognosis of breast cancer. In this study, we assessed the additional predictive value of the 70-gene MammaPrint signature for chemotherapy (CT) benefit in addition to endocrine therapy (ET) from pooled study series. For 541 patients who received eithe... | ['Adenocarcinoma', 'Adult', 'Aged', 'Anthracyclines', 'Antineoplastic Agents, Hormonal', 'Antineoplastic Combined Chemotherapy Protocols', 'Breast Neoplasms', 'Chemotherapy, Adjuvant', 'Combined Modality Therapy', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Middle Aged', ... | 20,204,499 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['D02.455.426.559.847.562.050', 'D04.615.562.050', 'D09.408.051.059'], ['D27.505.954.248.169'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.180', 'C17.800.090.500'], ['E02.186.170', 'E02.319.170'], ['E02.186'], ['E05.393.332'], ['G... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Liver p53 expression in patients with HCV-related chronic hepatitis. | Mutated p53 acts as a dominant oncogene and alterations in the p53 gene are described in a large number of patients with hepatocellular carcinoma (HCC). It has been demonstrated that hepatitis C virus (HCV)-core protein regulates transcriptionally cellular genes, as well as cell growth and apoptosis. This study was und... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Biopsy, Needle', 'Case-Control Studies', 'Chi-Square Distribution', 'Cohort Studies', 'DNA, Viral', 'Female', 'Gene Expression Regulation, Viral', 'Genetic Predisposition to Disease', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Immunohistochemistry', 'Male', 'Middl... | 12,823,592 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E05.318.372.500.500', 'N05.715... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Incomplete bacteriophage-like particles in ultraviolet-irradiated haemophilus. | Incomplete phagelike particles were found in competent and incompetent cells of Haemophilus influenzae Rd (transformable) lysed after exposure to ultraviolet radiation. | ['Bacteriocins', 'Bacteriolysis', 'Bacteriophages', 'Defective Viruses', 'Haemophilus', 'Haemophilus influenzae', 'Microscopy, Electron', 'Radiation Effects', 'Ultraviolet Rays'] | 5,305,777 | [['D12.776.097.151', 'D12.776.543.695.110'], ['G06.099.115'], ['B04.123'], ['B04.265'], ['B03.440.450.600.450', 'B03.660.250.550.290'], ['B03.440.450.600.450.330', 'B03.660.250.550.290.330'], ['E01.370.350.515.402', 'E05.595.402'], ['G01.750.745', 'N06.850.810.300'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of age and neurovascular grafting on the mechanical function of medial gastrocnemius muscles of Fischer 344 rats. | Both aging and grafting of whole skeletal muscle are associated with decreased specific force and resistance to fatigue. This study tested the hypothesis that the recovery of mechanical function in nerve-repair skeletal muscle grafts in senescent rats would be impaired compared with recovery in similar grafts in younge... | ['Age Factors', 'Aging', 'Analysis of Variance', 'Animals', 'Male', 'Muscle Contraction', 'Muscle Denervation', 'Muscle, Skeletal', 'Nerve Fibers', 'Nerve Regeneration', 'Rats', 'Rats, Inbred F344', 'Recovery of Function'] | 18,314,554 | [['N05.715.350.075', 'N06.850.490.250'], ['G07.345.124'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G11.427.494'], ['E04.525.210.500', 'E04.525.210.560.500'], ['A02.633.567', 'A10.690.552.500'], ['A08.675.542', 'A11.671.501'], ['G11.561.585', 'G16.762.611'], ['B01.050.150.900.649... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
From cytoplasm to environment: the inorganic ingredients for the origin of life. | Early in its history, Earth's surface developed from an uninhabitable magma ocean to a place where life could emerge. The first organisms, lacking ion transporters, fixed the composition of their cradle environment in their intracellular fluid. Later, though life adapted and spread, it preserved some qualities of its i... | ['Atmosphere', 'Bacteria', 'Carbon Dioxide', 'Cations', 'Cytoplasm', 'Elements', 'Environment', 'Hydrothermal Vents', 'Inorganic Chemicals', 'Methane', 'Models, Theoretical', 'Oceans and Seas', 'Origin of Life', 'Seawater'] | 23,406,344 | [['G16.500.275.063', 'N06.230.300.100'], ['B03'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D01.248.497.300'], ['A11.284.430.214'], ['D01.268'], ['G16.500.275', 'N06.230'], ['G01.311.355.750.500.400', 'G16.500.275.260.750'], ['D01'], ['D02.455.326.146.571'], ['E05.599'], ['G01.311.625', 'G16.500.275.725.500.... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Characterization of the synergistic antiproliferative effects of interferon-gamma and tumor necrosis factor on human colon carcinoma cell lines. | We employed a tumor-type-specific tissue culture model utilizing three human colon carcinoma cell lines to (i) assess the effects of schedule, sequence, dose, and duration of exposure on the antiproliferative activity of combinations of tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) and to (ii) determine ... | ['Cell Division', 'Colonic Neoplasms', 'Drug Synergism', 'GTP-Binding Proteins', 'Humans', 'Interferon Type I', 'Interferon-gamma', 'Myxovirus Resistance Proteins', 'Neoplasm Proteins', 'Protein Biosynthesis', 'Statistics as Topic', 'Time Factors', 'Tumor Cells, Cultured', 'Tumor Necrosis Factor-alpha'] | 2,111,352 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['G07.690.773.968.477'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['B01.050.150.900.649.313.988.4... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Pharmacokinetics of mycophenolate mofetil in children with lupus and clinical findings in favour of therapeutic drug monitoring. | AIMS: The use of mycophenolate mofetil (MMF) in children with systemic lupus erythematosus (SLE) is increasing. However, the clinical benefit of its monitoring has been scarcely studied, and little is known about its pharmacokinetics in this context. The objectives of the present study were: (i) to describe mycophenoli... | ['Adolescent', 'Area Under Curve', 'Bayes Theorem', 'Child', 'Child, Preschool', 'Drug Monitoring', 'Female', 'Humans', 'Immunosuppressive Agents', 'Logistic Models', 'Lupus Erythematosus, Systemic', 'Male', 'Mycophenolic Acid', 'Retrospective Studies'] | 24,697,955 | [['M01.060.057'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.520.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E05.318.74... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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