Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Short-Term Exposure to a Calorically Dense Diet Alters Taste-Evoked Responses in the Chorda Tympani Nerve, But Not Unconditioned Lick Responses to Sucrose. | Upon presentation of a calorically dense diet, rats display hyperphagia driven by increased meal size. The increased meal size and hyperphagia are most robust across the first several days of diet exposure before changes in body weight are evident, thus it is plausible that one of the factors that drives the hyperphagi... | ['Animal Feed', 'Animals', 'Chorda Tympani Nerve', 'Diet', 'Energy Intake', 'Feeding Behavior', 'Food Preferences', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Sucrose', 'Taste'] | 29,860,418 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['A08.800.800.120.250.120'], ['G07.203.650.240'], ['G07.203.650.240.340'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F01.145.407.516', 'G07.203.650.353.516'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.7... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Enzootic aspergillosis in wild red vented cockatoos in the Philippines. | Philippine Red Vented Cockatoos were being trapped in the wild and dispersed directly to private homes, aviaries, pet stores and for export to the United States of America. Except for non-aggressive behaviour and tiring easily the subjects showed clinically nothing peculiar. Numerous cases of Aspergillosis with no clin... | ['Animals', 'Aspergillosis', 'Aspergillus fumigatus', 'Bird Diseases', 'Birds', 'Philippines'] | 7,012,630 | [['B01.050'], ['C01.150.703.080'], ['B01.300.381.081.295'], ['C22.131'], ['B01.050.150.900.248'], ['Z01.252.145.671', 'Z01.639.790']] | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Efficacy study of novel diamidine compounds in a Trypanosoma evansi goat model. | Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of these compounds were additionally carried out. Goats demonstrated no signs of acute toxicity, when treated with four doses ... | ['Animals', 'Dose-Response Relationship, Drug', 'Female', 'Goats', 'Mice', 'Models, Animal', 'Trypanocidal Agents', 'Trypanosoma'] | 21,698,106 | [['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.500.380.513'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.598'], ['D27.505.954.122.250.100.875'], ['B01.268.475.868.887']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrical stimulation prevents immobilization atrophy in skeletal muscle of rabbits. | OBJECTIVE: To investigate the effect of unilateral cast immobilization with and without surface electrical stimulation (ES) on the tibialis anterior (TA) muscle of rabbits.DESIGN: Prospective randomized trial.SETTING: University medical school.ANIMALS: 53 New Zealand White rabbits (aged 54 to 63 days, weight 1.73 to 1.... | ['Animals', 'Electric Stimulation Therapy', 'Female', 'Immobilization', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Muscular Atrophy', 'Organ Size', 'Prospective Studies', 'Rabbits', 'Random Allocation'] | 9,161,371 | [['B01.050'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E05.472'], ['A10.690.552.500.500', 'A11.620.249'], ['A02.633.567', 'A10.690.552.500'], ['C10.597.613.612', 'C23.300.070.500', 'C23.888.592.608.612'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['E05.318.372.500.750... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Coagulation screen is more specific than the anticardiolipin antibody ELISA in defining a thrombotic subset of lupus patients. | In 111 lupus patients we compared the potential of the IgG and IgM anticardiolipin antibody (ACA) enzyme linked immunosorbent assay (ELISA) and four different lupus anticoagulant (LAC) assays (partial thromboplastin time (PTT) of a 1:1 mixture of patient and control plasma with phospholipids from animal (PTT-st) or hum... | ['Adolescent', 'Adult', 'Aged', 'Autoantibodies', 'Blood Coagulation Factors', 'Cardiolipins', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Fetal Death', 'Humans', 'Lupus Coagulation Inhibitor', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Partial Thromboplastin Time', 'Phospholipids', 'Pregnancy', 'Thro... | 3,133,992 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D12.776.124.125', 'D23.119'], ['D10.570.755.375.760.400.885.185', 'D23.050.550.480.330'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.60... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Functional assessment of coronary artery stenosis by doppler derived absolute and relative coronary blood flow velocity reserve in comparison with (99m)Tc MIBI SPECT. | OBJECTIVE: To determine the relation between the relative and absolute coronary blood flow velocity reserve (CFVR) compared with the results of (99m)Tc MIBI single photon emission computed tomography (SPECT).METHODS: In 37 patients with one vessel disease, (99m)Tc MIBI SPECT was performed before angioplasty, two to thr... | ['Adult', 'Aged', 'Angioplasty, Balloon, Coronary', 'Blood Flow Velocity', 'Coronary Angiography', 'Coronary Circulation', 'Coronary Disease', 'Echocardiography, Doppler', 'Female', 'Follow-Up Studies', 'Heart', 'Humans', 'Male', 'Middle Aged', 'Regression Analysis', 'Tomography, Emission-Computed, Single-Photon'] | 10,490,570 | [['M01.060.116'], ['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.350.130.625', 'E01.370.35... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Signaling survival: how axons rescue their glia. | The trophic theory of cell survival hypothesizes that cell number is regulated by survival signals generated by other cells. Work published in this issue of Developmental Cell confirms that neurons can provide trophic support for glia in Drosophila, and fills in important molecular details of this interaction. | ['Animals', 'Axons', 'Cell Survival', 'Drosophila', 'Drosophila Proteins', 'Epidermal Growth Factor', 'ErbB Receptors', 'Membrane Proteins', 'Mitogen-Activated Protein Kinases', 'Models, Biological', 'Neuroglia', 'Signal Transduction', 'ras Proteins'] | 11,832,236 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['G04.346'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.63... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The strongest prescription of all: a week in the woods. | As the sun sets behind the first campfire, children's faces are silhouetted in the darkness. In this moment and the days to follow at Camp Sunrise, it is impossible to tell who is living with HIV/AIDS and who is not. According to Jina Gonzalez, that is precisely the point of camps-like Ohio-based Camp Sunrise-that are ... | ['Acquired Immunodeficiency Syndrome', 'Camping', 'Child', 'HIV Infections', 'Humans', 'Self-Help Groups'] | 19,797,734 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['I03.450.642.159'], ['M01.060.406'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.6... | ['Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Medicolegal evaluation of a maternal filicide attempt: a case report. | Foto-?zdemir D, Balseven-Odaba?? A, Tek?am ?, Karada? F, Ak?an F, Y?lmaz E. Medicolegal evaluation of a maternal filicide attempt: a case report. Turk J Pediatr 2019; 61: 622-628. Filicide mainly refers to the murder of a child by his/her parents. Even though filicide is a rare event, outcome of filicide is more severe... | ['Adult', 'Child Abuse', 'Child, Preschool', 'Female', 'Forensic Medicine', 'Homicide', 'Humans', 'Mother-Child Relations', 'Mothers'] | 31,990,486 | [['M01.060.116'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['M01.060.406.448'], ['H02.403.330', 'I01.198.780.937'], ['I01.198.240.470', 'I01.880.735.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290.170'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
[Stress and fracture healing]. | Stress is an important factor in fracture healing, but it is not the only one. The exact amount of stress, displacement or strain needed or tolerated in fracture healing is not yet clear. There are numerous modifying factors influencing fracture healing like fracture type, soft tissue injury, vitality of fragments, typ... | ['Bony Callus', 'External Fixators', 'Fracture Healing', 'Fractures, Bone', 'Humans', 'Joint Prosthesis', 'Orthopedic Fixation Devices', 'Prosthesis Failure', 'Pseudarthrosis', 'Radiography', 'Stress, Mechanical', 'Tensile Strength'] | 7,478,504 | [['A10.165.265.200'], ['E07.858.442.660.430', 'E07.858.690.725.430'], ['G16.762.891.500'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.400'], ['E07.858.442.660', 'E07.858.690.725'], ['C23.550.767.865', 'E05.325.771'], ['C26.404.468.627'], ['E01.370.350.700'], ['G01.374.835'], ['G01.374.850']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. | 1. A potent and highly selective DP prostanoid receptor antagonist radioligand, [(3)H]-cyclohexyl-N-BWA868C (3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethyl-amino) hydantoin, ([(3)H]-BWA868C)), has been generated for receptor binding and autoradiographic studies. 2. Specific [(3)H]-BWA868C binding to human p... | ['Autoradiography', 'Blood Platelets', 'Cell Membrane', 'Eye', 'Humans', 'Hydantoins', 'Platelet Aggregation Inhibitors', 'Prostaglandin D2', 'Receptors, Immunologic', 'Receptors, Prostaglandin'] | 11,082,108 | [['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A11.118.188', 'A15.145.229.188'], ['A11.284.149'], ['A01.456.505.420', 'A09.371'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308.432.555'], ['D27.505.954.502.780'], ['D10.251.355.255.550.200.200', 'D23.469.050.175.725.200.200'], ['D12.77... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A three-year study of brain atrophy after autologous hematopoietic stem cell transplantation in rapidly evolving secondary progressive multiple sclerosis. | BACKGROUND AND PURPOSE: In multiple sclerosis (MS), autologous hematopoietic stem cell transplantation (AHSCT) induces a profound suppression of clinical activity and MR imaging-detectable inflammation, but it may be associated with a rapid brain volume loss in the months subsequent to treatment. The aim of this study ... | ['Adult', 'Atrophy', 'Brain Diseases', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Longitudinal Studies', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multiple Sclerosis, Chronic Progressive', 'Treatment Outcome'] | 17,885,242 | [['M01.060.116'], ['C23.300.070'], ['C10.228.140'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.114.375.500.200', 'C10.3... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Protective antioxidant effects of carvedilol in a rat model of ischaemia-reperfusion injury. | This study investigated the protective effects of carvedilol, a potent antioxidant, in a rat model of tourniquet-induced ischaemia-reperfusion injury of the hind limb. Thirty rats were divided equally into three groups: the control group (group 1) was only anaesthetized, without creating an ischaemia-reperfusion injury... | ['Animals', 'Antioxidants', 'Carbazoles', 'Carvedilol', 'Hindlimb', 'Humans', 'Lipid Peroxidation', 'Male', 'Muscle, Skeletal', 'Nitric Oxide', 'Propanolamines', 'Rats', 'Rats, Sprague-Dawley', 'Reperfusion Injury', 'Tourniquets', 'Ultrasonography, Doppler, Color', 'Vasodilator Agents'] | 16,222,886 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D03.633.100.473.144', 'D03.633.300.148'], ['D02.033.100.624.151', 'D02.033.755.624.151', 'D02.092.063.624.151', 'D03.633.100.473.144.125', 'D03.633.300.148.125'], ['A13.473'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.515', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The CD40-autophagy pathway is needed for host protection despite IFN-Ã-dependent immunity and CD40 induces autophagy via control of P21 levels. | Autophagy degrades pathogens in vitro. The autophagy gene Atg5 has been reported to be required for IFN-ã-dependent host protection in vivo. However, these protective effects occur independently of autophagosome formation. Thus, the in vivo role of classic autophagy in protection conferred by adaptive immunity and how ... | ['Animals', 'Apoptosis Regulatory Proteins', 'Autophagy', 'Beclin-1', 'CD40 Antigens', 'Gene Expression Regulation', 'Genetic Predisposition to Disease', 'Immune System', 'Interferon-gamma', 'Mice', 'Mice, Inbred C57BL', 'Nitric Oxide Synthase Type II', 'Phagosomes', 'Toxoplasma', 'Toxoplasmosis', 'Tumor Necrosis Facto... | 21,217,818 | [['B01.050'], ['D12.644.360.075', 'D12.776.476.075'], ['G04.011'], ['D12.644.360.075.335', 'D12.776.094.500', 'D12.776.476.075.335'], ['D12.776.465.750', 'D12.776.543.750.705.852.760.097', 'D23.050.301.264.051.140', 'D23.101.100.150.140'], ['G05.308'], ['C23.550.291.687.500', 'G05.380.355'], ['A15.382'], ['D12.644.276.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Staying Together: A Bidirectional Delay-Coupled Approach to Joint Action. | To understand how individuals adapt to and anticipate each other in joint tasks, we employ a bidirectional delay-coupled dynamical system that allows for mutual adaptation and anticipation. In delay-coupled systems, anticipation is achieved when one system compares its own time-delayed behavior, which implicitly includ... | ['Anticipation, Psychological', 'Cooperative Behavior', 'Feedback, Sensory', 'Humans', 'Music', 'Psychomotor Performance', 'Time Factors'] | 31,446,664 | [['F02.463.093'], ['F01.145.813.115'], ['F04.754.137.301.500', 'F04.754.308.500.500', 'F04.754.339', 'G07.410.732.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.602'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['G01.910.857']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Necrotic inflammatory reaction induced by muramyl dipeptide in guinea pigs sensitized by tubercle bacilli. | In the course of studies aimed at determining whether MDP was antigenic or not, a hitherto unreported phenomenon was noticed. Injection (a provocative injection) of muramyl dipeptide (MDP) caused severe inflammation, with hemorrhage and necrosis in the footpads of guinea pigs, where tubercle bacilli in water-oil emulsi... | ['Acetylmuramyl-Alanyl-Isoglutamine', 'Adjuvants, Immunologic', 'Animals', 'Dose-Response Relationship, Immunologic', 'Female', 'Guinea Pigs', 'Hypersensitivity, Delayed', 'Inflammation', 'Mycobacterium tuberculosis', 'Necrosis', 'Shwartzman Phenomenon', 'Time Factors'] | 3,926,935 | [['D09.067.550.050', 'D09.811.522.050', 'D12.644.233.050'], ['D27.505.696.477.067'], ['B01.050'], ['G12.300'], ['B01.050.150.900.649.313.992.550'], ['C20.543.418'], ['C23.550.470'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['C23.550.717'], ['C14.907.454.810', 'C14.907.940.890', 'C15.378.463.515.8... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TS-Chemscore, a Target-Specific Scoring Function, Significantly Improves the Performance of Scoring in Virtual Screening. | Most of the scoring functions currently used in structure-based drug design belong to 'universal' scoring functions, which often give a poor correlation between the calculated scores and experimental binding affinities. In this investigation, we proposed a simple strategy to construct target-specific scoring functions ... | ['Drug Design', 'Drug Evaluation, Preclinical', 'Humans', 'Janus Kinase 3', 'Protein Kinase Inhibitors', 'Protein Tyrosine Phosphatases'] | 25,358,259 | [['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['E05.290.750', 'E05.337.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.725.124.300', 'D12.776.476.393.300'], ['D27.505.519.389.755'], ['D08.811.277.352.650.775']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. | We have determined the first genomic structure and characterized the mRNA and protein products of a novel vertebrate gene that encodes a calcium-binding protein with amino acid sequence identity to a protein kinase domain. The elucidation of the complete DNA sequence of this transcription unit and adjacent genomic DNA,... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Calcium-Binding Proteins', 'Calmodulin', 'Cells, Cultured', 'Chick Embryo', 'Chickens', 'Cloning, Molecular', 'DNA', 'Electrophoresis, Polyacrylamide Gel', 'Exons', 'Genes', 'Genome', 'Gizzard, Avian', 'Immunoblotting', 'Introns', 'Kinesin', 'Molecular Sequence Data'... | 1,373,815 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157.125'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Human immunodeficiency virus type 1 infection of endothelial cells in vitro. | In order to establish whether endothelial cells are involved in immunodeficiency virus type 1 (HIV-1) infection, we performed a virological study on endothelial cells isolated from human adipose tissue and infected with HIV-1 in vitro. Supernatants from cultures showed a reverse transcriptase activity starting one day ... | ['Adipose Tissue', 'Cells, Cultured', 'Cycloheximide', 'Endothelium', 'Gene Products, gag', 'HIV Antigens', 'HIV Core Protein p24', 'HIV-1', 'Humans', 'RNA-Directed DNA Polymerase', 'Viral Core Proteins', 'Virus Replication'] | 1,713,288 | [['A10.165.114'], ['A11.251'], ['D03.383.621.808.240'], ['A10.272.491'], ['D12.776.775.330', 'D12.776.964.775.350', 'D12.776.964.970.600.850.350'], ['D23.050.327.520'], ['D12.776.964.775.350.362.500', 'D12.776.964.775.562.750.500', 'D12.776.964.970.600.850.350.362.500', 'D23.050.327.520.300'], ['B04.820.650.589.650.350... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two siblings with autoimmune neutropenia of infancy. | We report two siblings with autoimmune neutropenia of infancy. Patient 1 was hospitalized for viral gastroenteritis at 5 months of age, when his absolute neutrophil count was 684/mm3. Absolute neutrophil counts ranging from 0 to 930/mm3 continued but normalized spontaneously at 25 months of age. Patient 2, a younger br... | ['Autoantibodies', 'Autoimmune Diseases', 'Humans', 'Infant', 'Male', 'Neutropenia', 'Neutrophils'] | 1,801,552 | [['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C20.111'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C15.378.553.546.184.564'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583', 'A15.382.490.315.583', 'A15.382... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
SDS-PAGE analysis of caput epididymis proteins in rats receiving a zinc deficient diet. | Caput epididymis proteins from control, pairfed and zinc deficient (ZD) wistar weanling albino rats after 2-, 4-, 6- and 8-weeks were examined using SDS-PAGE followed by densitometric scanning of the gels. In comparison to the control and pairfed rats, ZD rats displayed new proteins. These included a Mr 42 kDa from 2ZD... | ['Animals', 'Diet', 'Electrophoresis, Polyacrylamide Gel', 'Epididymis', 'Male', 'Molecular Weight', 'Proteins', 'Rats', 'Rats, Wistar', 'Zinc'] | 11,395,953 | [['B01.050'], ['G07.203.650.240'], ['E05.196.401.402', 'E05.301.300.319'], ['A05.360.444.371'], ['G02.494'], ['D12.776'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The intravenous furosemide test: a simple way to evaluate renin responsiveness. | To identify patients with low-renin hypertension, we measured plasma renin activity after the administration of 40 mg of furosemide intravenously and 30 minutes of upright posture in 127 normotensive subjects and 363 patients with essential hypertension. Plasma renin activity 30 minutes after intravenous furosemide was... | ['Adult', 'Diet, Sodium-Restricted', 'Female', 'Furosemide', 'Humans', 'Hypertension', 'Injections, Intravenous', 'Male', 'Middle Aged', 'Posture', 'Renin', 'Sodium'] | 937,875 | [['M01.060.116'], ['E02.642.249.290', 'G07.203.650.240.290'], ['D02.065.884.725.300', 'D02.092.146.807.300', 'D02.886.590.700.725.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['M01.060.116.630'], ['G11.427.695'], ['D08.811.277.656.074.500.780',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai. | [reaction: see text] A 12-step total synthesis of the tricyclic heteroaromatic marine metabolite ageladine A has been achieved using a 6pi-azaelectrocyclization and a Suzuki-Miyaura coupling of N-Boc-pyrrole-2-boronic acid with a chloropyridine as key steps. | ['Agelas', 'Angiogenesis Inhibitors', 'Animals', 'Catalysis', 'Hydrocarbons, Brominated', 'Marine Biology', 'Molecular Structure', 'Pyrroles'] | 16,562,912 | [['B01.050.500.802.039'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['G02.130'], ['D02.455.526.368'], ['H01.158.273.248.750.500', 'H01.277.249.750.500', 'H01.277.750.500'], ['G02.111.570', 'G02.466'], ['D03.383.129.578']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Client perspectives on an Aboriginal community led oral health service in rural Australia. | OBJECTIVE: An oral health service was implemented, using a unique community development approach, for Northern NSW Australian Aboriginal communities in 2013-14. This study examined the views of children (and parents) who accessed the service, including: the extent of reported dental problems, oral health knowledge, att... | ['Adolescent', 'Child', 'Child, Preschool', 'Cultural Characteristics', 'Dental Care for Children', 'Dental Health Services', 'Female', 'Health Knowledge, Attitudes, Practice', 'Health Services Accessibility', 'Health Services, Indigenous', 'Health Status Indicators', 'Humans', 'Male', 'New South Wales', 'Oceanic Ances... | 27,377,919 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['E06.170.152', 'N02.421.240.190.215'], ['N02.421.240'], ['F01.100.150.500', 'N05.300.150.410'], ['N04.590.374.350', 'N05.300.430'], ['N02.421.330'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.85... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Combinatorial coating of adhesive polypeptide and anti-CD34 antibody for improved endothelial cell adhesion and proliferation. | Improved attachment, adhesion and proliferation of the surrounding mature endothelial cells (ECs) and circulating endothelial progenitor cells (EPCs) is of primary importance to realize the in situ rapid re-endothelialization of cardiovascular stents. To achieve this, a combinatorial coating of synthesized mussel adhes... | ['Adhesiveness', 'Antibodies, Monoclonal', 'Antigens, CD34', 'Cell Adhesion', 'Cell Proliferation', 'Cells, Cultured', 'Coated Materials, Biocompatible', 'Combinatorial Chemistry Techniques', 'Endothelial Cells', 'Humans', 'Materials Testing', 'Peptides', 'Protein Binding'] | 19,247,584 | [['G02.860.139'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['G04.022'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D25.130.420', 'J01.637.051.130.420'], ['E05.197.312', 'J01.897.836.249.249'], ['A11.436... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Impact of HLA-DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort. | Associations between HLA class II polymorphisms and HIV control were assessed in a Peruvian MSM cohort. Among 233 treatment na?ve HIV+ individuals, DRB1*13:02 was linked to elevated viral loads (P = .044) while DRB1*12:01 showed significantly lower viral set points (P = .015) and restricted a dominant T cell response t... | ['Adult', 'Alleles', 'CD4-Positive T-Lymphocytes', 'Cohort Studies', 'Female', 'Gene Expression', 'Gene Frequency', 'HIV Infections', 'HIV-1', 'HLA-DRB1 Chains', 'Homosexuality, Male', 'Humans', 'Male', 'Peru', 'Polymorphism, Genetic', 'Viral Load'] | 28,677,168 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G05.297'], ['G05.330'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.92... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Complications with the four-loop lens of Binkhorst (the iris-clip lens). | The iris-clip (four-loop) lens of Binkhorst has been and continues to be the best intraocular lens on the market. It is recommended for primary or secondary implantation in an eye with a suitable iris sphincter and anterior chamber. Complications may occur, but these can be minimized by appropriate treatment and, parti... | ['Humans', 'Intraoperative Complications', 'Lenses, Intraocular', 'Postoperative Complications'] | 537,771 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DNA nicking--closing activity from salmon testis. | Salmon testis is a good source of DNA nicking--closing (N--C) enzyme, as expected for rapidly proliferating cells. Partial purification was obtained but it resulted in an unstable form of N--C enzyme. Cruder fractions are useful for relaxing supercoiled DNA under conditions where other N--C enzymes are inactive. The en... | ['Animals', 'DNA Topoisomerases, Type I', 'Male', 'Salmon', 'Testis'] | 204,402 | [['B01.050'], ['D08.811.399.403.483', 'D12.776.157.687.375', 'D12.776.660.720.375'], ['B01.050.150.900.493.817.750.705'], ['A05.360.444.849', 'A05.360.576.782', 'A06.300.312.782']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Trochanteric pressure in spinal cord injury. | Pressure-induced tissue breakdown is a frequent and life-threatening complication for individuals with spinal cord injury. These patients are frequently positioned on their sides to relieve back and sacral pressure while they are in bed. This position causes high trochanteric pressure with the potential for the develop... | ['Adolescent', 'Adult', 'Female', 'Femur', 'Humans', 'Male', 'Middle Aged', 'Monitoring, Physiologic', 'Pressure', 'Pressure Ulcer', 'Spinal Cord Injuries'] | 7,138,267 | [['M01.060.057'], ['M01.060.116'], ['A02.835.232.043.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520'], ['G01.374.715'], ['C17.800.893.665'], ['C10.228.854.763', 'C10.900.850', 'C26.819']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk. | Breast and ovarian cancers increased in the last decades. Except rare cases with a genetic predisposition and high penetrance, these pathologies are viewed as a polygenic disease. In this concept, association studies look for genetic variations such as polymorphisms in low penetrance genes, i.e. genes in interaction wi... | ['Breast Neoplasms', 'DNA Repair', 'Female', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Odds Ratio', 'Ovarian Neoplasms', 'Polymorphism, Genetic', 'Polymorphism, Single Nucleotide', 'Risk Factors', 'Xeroderma Pigmentosum Group D Protein'] | 18,454,848 | [['C04.588.180', 'C17.800.090.500'], ['G02.111.222', 'G05.219'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.625.590', 'N06.850.520.830.600.600'], ['C04.588.322.455', 'C13.351.500.056.630.705',... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The degradation of amino acids, proteins, and blood to short-chain fatty acids in colon is prevented by lactulose. | Short-chain (C2-C5) fatty acids account for 60%-70% of the anions in the colon. Acetate (C2) is nontoxic in contrast to C(3)4-C5 fatty acids (propionate, butyrate, isobutyrate, valerate, and isovalerate), which induce coma in animals and may be important in the pathogenesis of hepatic coma in humans. An in-vitro fecal ... | ['Albumins', 'Amino Acids', 'Blood', 'Colon', 'Disaccharides', 'Fatty Acids, Volatile', 'Feces', 'Hepatic Encephalopathy', 'Humans', 'Hydrogen-Ion Concentration', 'Lactulose'] | 2,295,390 | [['D12.776.034'], ['D12.125'], ['A12.207.152', 'A15.145'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D09.698.629.305', 'D09.947.750'], ['D10.251.400'], ['A12.459'], ['C06.552.308.500.356', 'C10.228.140.163.360', 'C18.452.132.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D09.698.629.305.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alefacept is safe and efficacious in the treatment of palmar plantar pustulosis. | BACKGROUND: Alefacept blocks T-cell activation and induces apoptosis of memory T cells. It improves psoriasis vulgaris and may induce prolonged remissions. Experience with alefacept in palmar plantar pustulosis (PPP) is limited.OBJECTIVE: The objective of the study was to observe the effectiveness and safety of aleface... | ['Alefacept', 'Chronic Disease', 'Dermatologic Agents', 'Female', 'Follow-Up Studies', 'Humans', 'Injections, Intramuscular', 'Male', 'Middle Aged', 'Pilot Projects', 'Psoriasis', 'Recombinant Fusion Proteins', 'Severity of Illness Index', 'Treatment Outcome'] | 18,042,332 | [['D12.776.124.486.485.114.619.393.131', 'D12.776.124.790.651.114.619.393.131', 'D12.776.377.715.548.114.619.393.131', 'D12.776.395.550.034.500', 'D12.776.543.550.158.500', 'D12.776.828.300.100'], ['C23.550.291.500'], ['D27.505.954.444'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.7... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Association among gestation length and health, production, and reproduction in Holstein cows and implications for their offspring. | Objectives were to evaluate associations among gestation length (GL) and performance in Holstein cows and their offspring. A total of 8,095 Holstein cows and 3,635 female offspring born alive on 2 farms using only artificial insemination (AI) were evaluated. Gestation length averaged 276 ± 6 d in the 8,095 dams, and it... | ['Animals', 'Cattle', 'Female', 'Insemination, Artificial', 'Lactation', 'Milk', 'Parity', 'Pregnancy', 'Pregnancy, Animal', 'Reproduction'] | 28,161,176 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E02.875.800.937', 'E05.820.800.937', 'G08.686.784.363.492'], ['G08.686.523', 'G08.686.702.500'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['G08.686.677', 'G08.686.784.769.472', 'N06.850.490.812.600'],... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Fine-needle aspiration of renal masses in adults: analysis of results and diagnostic problems in 108 cases. | Fine-needle aspiration (FNA) biopsy of the kidney has a traditionally well-defined role in the diagnosis and treatment of renal lesions. Recent improvements in renal imaging techniques have also brought renal FNA to the forefront, since small and asymptomatic renal masses are increasingly being detected. Before the phy... | ['Adult', 'Biopsy, Needle', 'Humans', 'Kidney', 'Kidney Diseases'] | 10,352,906 | [['M01.060.116'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Tristetraprolin Overexpression in Gastric Cancer Cells Suppresses PD-L1 Expression and Inhibits Tumor Progression by Enhancing Antitumor Immunity. | The RNA-binding protein tristetraprolin (TTP) binds to adenosine-uridine AU-rich elements in the 3'-untranslated region of messenger RNAs and facilitates rapid degradation of the target mRNAs. Therefore, it regulates the expression of multiple cancer and immunity-associated transcripts. Furthermore, a lack of TTP in ca... | ['Apoptosis', 'B7-H1 Antigen', 'CD8-Positive T-Lymphocytes', 'Cell Line, Tumor', 'Cell Survival', 'Disease Progression', 'Female', 'Forkhead Transcription Factors', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Immunity', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Multivariate Analysis', 'RNA Stability',... | 29,936,792 | [['G04.146.954.035'], ['D12.776.465.625', 'D12.776.467.150.300', 'D12.776.543.095.300', 'D23.050.301.285.400', 'D23.529.168.300'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['C23.550.291.656'], ['D12.776.260.95... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expression of embryonic globins by erythroid cells in juvenile chronic myelocytic leukemia. | Juvenile chronic myelocytic leukemia (JCML) is a rare hematopoietic neoplasia of early childhood with distinct hematologic and biochemical features. We studied the biologic properties and the globin synthetic profiles of JCML erythroid cells both in vivo and in vitro from a total of 24 patients. In these cases we obser... | ['Bone Marrow', 'Cells, Cultured', 'Child, Preschool', 'Erythrocytes', 'Erythroid Precursor Cells', 'Erythropoietin', 'Globins', 'Humans', 'Infant', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'RNA, Messenger', 'Reticulocytes'] | 2,043,763 | [['A15.382.216'], ['A11.251'], ['M01.060.406.448'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['A11.148.378.590.837.250', 'A11.443.240.497', 'A11.872.378.590.817.250', 'A15.378.316.378.590.837.250'], ['D12.644.276.374.410.240.150', 'D12.776.395.240.150', 'D12.776.467.374.410.240.150', 'D23.529.374.410.240.150'... | ['Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Guillain-Barr? syndrome associated with Rocky Mountain spotted fever: case report and review. | We report a case of Guillain-Barr? syndrome (GBS) associated with Rocky Mountain spotted fever (RMSF). The patient initially presented with fever, rash, and an altered mental status, and he responded to therapy with intravenous doxycycline; serological data confirmed RMSF. Concurrent physical findings and results of ce... | ['Acyclovir', 'Anti-Bacterial Agents', 'Drug Therapy, Combination', 'Humans', 'Male', 'Metronidazole', 'Middle Aged', 'Polyradiculoneuropathy', 'Rocky Mountain Spotted Fever'] | 8,783,717 | [['D03.633.100.759.758.399.454.250'], ['D27.505.954.122.085'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.640.672.500', 'D03.383.129.308.658.500'], ['M01.060.116.630'], ['C10.114.750', 'C10.314.750', 'C10.668.829.800.750', 'C20.111.258.750'], ['C01.150.252.400.789.725.400.500', 'C01.920.930... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Conservation and diversification of the miR166 family in soybean and potential roles of newly identified miR166s. | BACKGROUND: microRNA166 (miR166) is a highly conserved family of miRNAs implicated in a wide range of cellular and physiological processes in plants. miR166 family generally comprises multiple miR166 members in plants, which might exhibit functional redundancy and specificity. The soybean miR166 family consists of 21 m... | ['Base Sequence', 'Chromosomes, Plant', 'Conserved Sequence', 'Evolution, Molecular', 'Gene Duplication', 'Gene Expression Regulation, Plant', 'MicroRNAs', 'Multigene Family', 'Phylogeny', 'Plant Proteins', 'Promoter Regions, Genetic', 'Regulatory Sequences, Ribonucleic Acid', 'Seeds', 'Soybeans', 'Stress, Physiologica... | 28,143,404 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.187.560', 'A18.005', 'G05.360.162.560'], ['G02.111.570.580'], ['G05.045.250', 'G16.075.250'], ['G05.365.590.320', 'G05.558.320'], ['G05.308.375'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['G05.360.340.024.340.645'], ['G... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Endobronchial ultrasound-guided transbronchial needle biopsy for the diagnosis of mediastinal lymphadenopathy in patients with extrathoracic malignancies. | BACKGROUND/AIM: Mediastinal lymphadenopathy is common in extrathoracic malignancies and should not always be considered a metastatic lesion. The purpose of this study is to determine the diagnostic value of endobronchial ultrasound-guided transbronchial needle biopsy (EBUS-TBNA) in patients with extrathoracic malignanc... | ['Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Endoscopic Ultrasound-Guided Fine Needle Aspiration', 'Female', 'Humans', 'Lymphatic Diseases', 'Male', 'Mediastinal Neoplasms', 'Middle Aged', 'Neoplasms', 'Sensitivity and Specificity', 'Young Adult'] | 25,552,152 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['E01.370.225.500.384.100.119.500.500', 'E01.370.225.500.384.100.370.500', 'E01.370.225.998.054.119.500.500', 'E01.370.225.998.054.370.500', 'E01.370.350.850.855.500', 'E01.370.388.100.100.500.500', 'E01.370.388.100.370.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Activation of Rab GTPase Sec4 by its GEF Sec2 is required for prospore membrane formation during sporulation in yeast Saccharomyces cerevisiae. | Sec2 activates Sec4 Rab GTPase as a guanine nucleotide exchange factor for the recruitment of downstream effectors to facilitate tethering and fusion of post-Golgi vesicles at the plasma membrane. During the meiosis and sporulation of budding yeast, post-Golgi vesicles are transported to and fused at the spindle pole b... | ['Biomarkers', 'Cell Membrane', 'Fluorescent Antibody Technique', 'Gene Expression Regulation, Fungal', 'Guanine Nucleotide Exchange Factors', 'Mutation', 'Phenotype', 'Protein Domains', 'Protein Transport', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Spores', 'rab GTP-Binding Proteins'] | 29,293,994 | [['D23.101'], ['A11.284.149'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G05.308.330'], ['D12.644.360.325.300', 'D12.776.476.325.300'], ['G05.365.590'], ['G05.695'], ['G02.111.570.820.709.275.750', 'G02.111.570.820.709.610.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Primary Gianturco stent placement for inferior vena cava abnormalities following liver transplantation. | PURPOSE: To determine the efficacy of primary Gianturco stent placement for patients with inferior vena caval (IVC) abnormalities following liver transplantation.MATERIALS AND METHODS: From August 1996 through March 1999, nine adult patients developed significant IVC abnormalities following liver transplantation. Patie... | ['Adult', 'Humans', 'Liver Transplantation', 'Postoperative Complications', 'Radiography', 'Stents', 'Vena Cava, Inferior'] | 10,716,387 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['C23.550.767'], ['E01.370.350.700'], ['E07.695.750'], ['A07.015.908.949.648']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Enantioselective synthesis of â-fluoroamines from â-amino alcohols: application to the synthesis of LY503430. | N,N-Dialkyl-â-amino alcohols were enantiospecifically and regioselectively rearranged by using N,N-diethylaminosulfur trifluoride (DAST) to give optically active â-fluoroamines in excellent yields and enantiomeric excesses. This rearrangement was applied to the enantioselective synthesis of LY503430, a potential therap... | ['Amides', 'Amines', 'Amino Alcohols', 'Biphenyl Compounds', 'Fluorine Compounds', 'Molecular Structure', 'Stereoisomerism'] | 20,849,096 | [['D02.065'], ['D02.092'], ['D02.033.100', 'D02.092.063'], ['D02.455.426.559.389.185'], ['D01.303'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Physical activity in daily life in patients with chronic low back pain. | OBJECTIVES: To evaluate disuse (ie, a decreased daily physical activity level) in patients with chronic low back pain (LBP) and to evaluate the construct validity of accelerometry for measuring physical activity in daily life.DESIGN: Case-control study in a cross-sectional design; comparison of accelerometry to the cri... | ['Activities of Daily Living', 'Body Composition', 'Body Mass Index', 'Case-Control Studies', 'Chronic Disease', 'Cross-Sectional Studies', 'Deuterium Oxide', 'Energy Metabolism', 'Exercise', 'Exercise Test', 'Female', 'Humans', 'Low Back Pain', 'Male', 'Middle Aged', 'Reproducibility of Results', 'Statistics, Nonparam... | 11,387,574 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.500'], ['E05.31... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation. | Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in patients with Rett syndrome, West syndrome, and X-linked infantile spasms sharing the common features of generally intractable early seizures and mental retardation. Disease-causing mutations are distributed in both the cataly... | ['Animals', 'Brain', 'Cell Nucleus', 'Chromosomes, Human, X', 'Humans', 'Infant, Newborn', 'Intellectual Disability', 'Methyl-CpG-Binding Protein 2', 'Mice', 'Mutation', 'NIH 3T3 Cells', 'Protein Structure, Tertiary', 'Protein-Serine-Threonine Kinases', 'Spasms, Infantile'] | 16,935,860 | [['B01.050'], ['A08.186.211'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.187.520.300.325.680', 'A11.284.187.865.982.500', 'G05.360.162.520.300.325.680', 'G05.360.162.865.982.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.7... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Merkel Cell Polyomavirus Infection and Detection. | Merkel cell polyomavirus (MCPyV) infection can lead to Merkel cell carcinoma (MCC), a highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV molecular biology and oncogenic mechanisms have been hampered by a lack of adequate cell culture models. Here, we describe a set of protocols for pe... | ['Cells, Cultured', 'DNA, Viral', 'Fibroblasts', 'Humans', 'In Situ Hybridization, Fluorescence', 'Merkel cell polyomavirus', 'Polyomavirus Infections', 'Skin'] | 30,799,855 | [['A11.251'], ['D13.444.308.568'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.350', 'E05.200.750.600.670.325.350', 'E05.393.285.350', 'E05.393.661.475.350'], ['B04.280.210.700.615.550', 'B04.613.204.67... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hematologic, biochemical, hormonal, and redox status alterations during reproductive activity in adult rams of two breeds. | BACKGROUND: Reproduction is a crucial, energy-consuming physiologic activity, which can temporarily disturb the homeostatic balance of the organism. Although rams are commonly placed in intense breeding programs on contemporary sheep farms, the clinicopathologic and redox status alterations have not been adequately stu... | ['Animals', 'Antioxidants', 'Blood Cell Count', 'Breeding', 'Male', 'Oxidation-Reduction', 'Oxidative Stress', 'Reproduction', 'Sheep', 'Species Specificity', 'Thyroxine'] | 31,062,434 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['E05.820.150', 'G05.090'], ['G02.700', 'G03.295.531'], ['G03.673', 'G07.775.750'], ['G08.686.784'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predictors of patients' perceived need for medication to prevent fracture. | BACKGROUND: Adherence with medications to prevent fractures is suboptimal. Patients' perceived need for medication is an important predictor of medication-use behavior.OBJECTIVE: Estimate the associations of patients' perceived need of medication for fracture prevention with objective indicators of fracture risk, patie... | ['Aged', 'Bone Density', 'Bone Density Conservation Agents', 'Cross-Sectional Studies', 'Diphosphonates', 'Female', 'Fractures, Bone', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Medication Adherence', 'Middle Aged', 'Multivariate Analysis', 'Physician-Patient Relations', 'Surveys and Questionnaires'] | 21,224,740 | [['M01.060.116.100'], ['G11.427.100'], ['D27.505.696.242'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D02.705.429.500'], ['C26.404'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600.500', 'F01.145.488.887.500.600.5... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn. | Objective To describe the pharmacokinetics and pharmacodynamics of milrinone in infants with persistent pulmonary hypertension of the newborn (PPHN) and to explore the impact of age on milrinone disposition. Design Randomized, open label pilot study. Setting Multicenter; level 3 and level 4 neonatal intensive care unit... | ['Administration, Intravenous', 'Cardiotonic Agents', 'Dose-Response Relationship, Drug', 'Endothelium-Dependent Relaxing Factors', 'Female', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Intensive Care Units, Neonatal', 'Male', 'Metabolic Clearance Rate', 'Milrinone', 'Nitric Oxide', 'Oxygen Consumption', 'Persiste... | 28,099,979 | [['E02.319.267.082'], ['D27.505.954.411.222', 'D27.720.799.080'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.954.411.918.500'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N02.278.388.493.390.380'], ['E01.370.225.843', 'E05.200.843', 'G03.49... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Experience of freezing human oocytes using sodium-depleted media. | Human embryo cryopreservation techniques enable the storage of surplus embryos created during assisted reproduction procedures; however, the existence of these same surplus embryos has sparked further debate. What can be their fate once they are no longer desired by their parents or if the parents are deceased? Thus, t... | ['Adult', 'Birth Weight', 'Brazil', 'Cohort Studies', 'Cryopreservation', 'Cryoprotective Agents', 'Embryo Transfer', 'Female', 'Gestational Age', 'Humans', 'Infertility', 'Oocytes', 'Patient Preference', 'Pregnancy', 'Pregnancy Outcome', 'Pregnancy Rate', 'Retrospective Studies', 'Sperm Injections, Intracytoplasmic'] | 21,123,115 | [['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['Z01.107.757.176'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Identification of the testing parameters in high frequency dynamic shear measurement on agarose gels. | Dynamic mechanical analysis (DMA) on agarose gels can be used to validate magnetic resonance elastography (MRE) measurements as well as to provide better understanding for the biological responses of cells to the dynamic loadings in cell culture studies. Various parameters potentially affecting the repeatability and ac... | ['Cell Culture Techniques', 'Gels', 'Humans', 'Materials Testing', 'Models, Biological', 'Sepharose', 'Shear Strength', 'Weight-Bearing'] | 15,713,317 | [['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['D20.280.320', 'D26.255.165.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.570'], ['E05.599.395'], ['D09.698.813'], ['G01.374.820'], ['G01.374.965']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multiple functional domains of the heparin molecule. | Affinity-fractionated porcine heparin was randomly scissioned by chemical techniques to give hexasaccharides, octasaccharides, decasaccharides, and mucopolysaccharide fragments of approximately 14 residues and approximately 16 residues that were able to complex with the protease inhibitor. Direct measurements of the ki... | ['Animals', 'Chromatography, Affinity', 'Factor X', 'Factor Xa', 'Heparin', 'Humans', 'Kinetics', 'Oligosaccharides', 'Structure-Activity Relationship', 'Swine', 'Thrombin'] | 6,940,150 | [['B01.050'], ['E05.196.181.400.170'], ['D08.622.471', 'D12.776.124.125.400', 'D12.776.811.243.471', 'D23.119.400'], ['D08.811.277.656.300.760.315', 'D08.811.277.656.959.350.315', 'D12.776.124.125.400.315', 'D23.119.400.315'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.11... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy and safety of high-dose ampicillin/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia. | OBJECTIVE: To compare the safety and efficacy of ampicillin/sulbactam (Amp/Sulb) and colistin (COL) in the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).METHODS: A prospective cohort study in adult critically ill patients with VAP. Patients were randomly assigned to rece... | ['Acinetobacter Infections', 'Acinetobacter baumannii', 'Aged', 'Ampicillin', 'Anti-Bacterial Agents', 'Colistin', 'Drug Resistance, Multiple, Bacterial', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pneumonia, Bacterial', 'Pneumonia, Ventilator-Associated', 'Sulbactam'] | 18,501,431 | [['C01.150.252.400.560.022'], ['B03.440.400.425.537.050.099', 'B03.660.250.530.050.099'], ['M01.060.116.100'], ['D02.065.589.099.750.750.050', 'D02.886.108.750.750.050', 'D03.633.100.300.750.750.050'], ['D27.505.954.122.085'], ['D04.345.566.780.110', 'D10.477.750.110', 'D12.644.050.600.110', 'D12.644.641.780.110', 'D12... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Zero order controlled release delivery of cholecalciferol from injectable biodegradable microsphere: In-vitro characterization and in-vivo pharmacokinetic studies. | Poly(lactic-co-glycolic acid) microspheres loaded with cholecalciferol (CL), more bioactive form of vitamin D was developed as an injectable controlled drug release system and was evaluated for its feasibility of once a month delivery. The CL loaded microspheres (CL-MS) were prepared by simple oil in water (O/W) emulsi... | ['Animals', 'Cholecalciferol', 'Delayed-Action Preparations', 'Drug Delivery Systems', 'Drug Liberation', 'Injections, Intramuscular', 'Lactic Acid', 'Microspheres', 'Polyglycolic Acid', 'Polylactic Acid-Polyglycolic Acid Copolymer', 'Rats, Sprague-Dawley', 'alpha-Tocopherol'] | 28,629,804 | [['B01.050'], ['D04.210.500.247.222.159', 'D04.210.500.247.808.146', 'D04.210.500.812.768.196', 'D10.570.938.146'], ['D26.255.210', 'E02.319.300.253'], ['E02.319.300'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['E02.319.267.530.460'], ['D02.241.511.459.450'], ['E07.565'], ['D05.750.728.780', 'D25.720.728.780', 'J... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
From directive to practice: are pictorial warnings and plain packaging effective to reduce the tobacco addiction? | OBJECTIVES: Tobacco packaging represents an important form of promotion of tobacco products and for this reason plain packaging (PP) can be considered an additional tobacco control measure. In Italy the current tobacco packaging is branded with textual warnings. The study investigated the perception of PP with textual ... | ['Adult', 'Cross-Sectional Studies', 'Female', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Motivation', 'Product Labeling', 'Product Packaging', 'Smoking Cessation', 'Tobacco Products', 'Tobacco Use Disorder'] | 26,452,706 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['J01.576.761.700'], ['J01.576.761'], ['F01.145.488.732'], ['J01.637.767.844'], ['C25.775.912', 'F03... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Factors Influencing Young Women's Preparedness for Their First Pelvic Examination. | OBJECTIVE: To understand factors contributing to women's level of preparedness for their first pelvic examination.METHODS: We conducted semistructured interviews with young women, aged 18-24 years, who had undergone at least one pelvic examination. This analysis explored 1) gynecologic and health care experience before... | ['Adolescent', 'Age Factors', 'Body Image', 'Female', 'Gynecological Examination', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Interviews as Topic', 'Physician-Patient Relations', 'Psychological Trauma', 'Qualitative Research', 'Sexual Behavior', 'Trust', 'Young Adult'] | 29,995,736 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.752.747.792.110', 'F02.463.593.112'], ['E01.370.600.293'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['F01.829.401.650.675'... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model. | Endothelial progenitor cells (EPCs) contribute to neovascularization in tumors. However, the relationship of EPCs and tumor-induced angiogenesis still remains to be clarified. The present study aimed at investigating the influence of 4 different tumor types on angiogenic properties of EPCs in an in vitro and in vivo ra... | ['Animals', 'Cell Communication', 'Cell Line, Tumor', 'Cytokines', 'Endothelial Progenitor Cells', 'Male', 'Neoplasm Proteins', 'Neoplasms, Experimental', 'Neovascularization, Pathologic', 'Rats'] | 29,746,168 | [['B01.050'], ['G04.085'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.148.174', 'A11.436.275.182'], ['D12.776.624'], ['C04.619', 'E05.598.500.496'], ['C23.550.589.500'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The evolution of racial, ethnic, and gender diversity in US otolaryngology residency programs. | OBJECTIVE: To examine the evolution of racial, ethnic, and gender diversity in US otolaryngology-head and neck surgery residency programs and compare these figures with other residency programs.DESIGN: Retrospective database review.SETTING: US residency programs.METHODS: Information concerning minority and female repre... | ['Continental Population Groups', 'Cultural Diversity', 'Ethnic Groups', 'Female', 'Humans', 'Internship and Residency', 'Male', 'Otolaryngology', 'Sex Ratio', 'Students', 'United States'] | 23,585,153 | [['M01.686.508'], ['I01.076.201.450.350', 'I01.880.853.100.450'], ['M01.686.754', 'N01.224.317'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.403.810.526'], ['G05.815', 'I01.240.800.815', 'N01.224.803.815', 'N06.850.505.400.850.815'], ['M01.848'], ['Z01.107.567... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
The "learning curve" for retropubic mid-urethral sling procedures: a retrospective cohort study. | INTRODUCTION AND HYPOTHESIS: Mid-urethral tape procedures brought a paradigm shift in surgery for stress incontinence; little research into the development and maintenance of surgical competence for the procedure exists. The hypothesis behind this study is that the "learning curve" for retropubic mid-urethral sling pro... | ['Clinical Competence', 'Female', 'Humans', 'Intraoperative Complications', 'Learning Curve', 'Operative Time', 'Patient Reported Outcome Measures', 'Postoperative Complications', 'Retrospective Studies', 'Suburethral Slings', 'Urinary Bladder', 'Urinary Incontinence, Stress', 'Urinary Retention', 'Urologic Surgical Pr... | 26,431,842 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['F02.784.629.529.274'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['E05.318.308.980.344.500', 'N03.349.380.210.750', 'N04.761.559.590.399.875', 'N05.425.210.500', 'N05.715.360.300.800.344.500', '... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Expression of aldo-keto reductase family 1 member C1 (AKR1C1) gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy. | BACKGROUND: The aldo-keto reductase family 1 member C1 (AKR1C1) belongs to a superfamily of NADPH-dependent reductases that convert a wide range of substrates, including carbohydrates, steroid hormones, and endogenous prostaglandins. The 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) is a member of AKR family. Th... | ['20-alpha-Hydroxysteroid Dehydrogenase', 'Amino Acid Sequence', 'Animals', 'Cell Size', 'Codon, Terminator', 'Databases, Nucleic Acid', 'Endometrium', 'Estrous Cycle', 'Female', 'Gene Expression Regulation, Enzymologic', 'Luteal Cells', 'Molecular Sequence Data', 'Molecular Weight', 'Ovary', 'Pregnancy', 'Pregnancy Pr... | 22,014,308 | [['D08.811.682.047.150.700.156.937', 'D08.811.682.047.820.125.074', 'D08.811.682.047.820.284.750'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G04.325'], ['D13.444.735.544.355.250', 'G05.360.335.355.250', 'G05.360.340.024.340.137.190.250'], ['L01.313.500.750.300.188.400.300.500', 'L01.313.500.750.300.18... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
High-resolution confocal microscopy by saturated excitation of fluorescence. | We demonstrate the use of saturated excitation in confocal fluorescence microscopy to improve the spatial resolution. In the proposed technique, we modulate the excitation intensity temporally and detect the harmonic modulation of the fluorescence signal which is caused by the saturated excitation in the center of the ... | ['Fluorescence', 'Microscopy, Confocal', 'Microscopy, Fluorescence'] | 18,233,334 | [['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.515.458', 'E05.595.458']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of external pelvic compression on electromyographic activity of the hamstring muscles during unipedal stance in sportsmen with and without hamstring injuries. | There is some evidence that hamstring function can be influenced by interventions focusing on the pelvis via an anatomic and neurophysiologic link between these two segments. Previous research demonstrated increased electromyographic activity from injured hamstrings during transition from bipedal to unipedal stance (BU... | ['Adult', 'Athletic Injuries', 'Biomechanical Phenomena', 'Buttocks', 'Cross-Over Studies', 'Electromyography', 'Hamstring Muscles', 'Humans', 'Injury Severity Score', 'Isometric Contraction', 'Male', 'Muscle Contraction', 'Postural Balance', 'Reference Values', 'Stress, Mechanical', 'Young Adult'] | 25,466,292 | [['M01.060.116'], ['C26.115'], ['G01.154.090', 'G01.374.089'], ['A01.378.610.100'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E01.370.405.255', 'E01.370.530.255'], ['A02.633.567.450', 'A10.690.552.500.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.875.500', 'E05... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Delayed (14-30 Days) Percutaneous Repair of Achilles Tendon Ruptures Offers Equally Good Results As Compared With Acute Repair. | BACKGROUND: Minimally invasive repair of acute Achilles tendon ruptures has been performed for several years, resulting in reduced morbidity as compared with open repair.HYPOTHESIS: A minimally invasive technique can be used to manage Achilles tendon ruptures in patients presenting between 14 and 30 days from injury.ST... | ['Achilles Tendon', 'Cohort Studies', 'Humans', 'Minimally Invasive Surgical Procedures', 'Rupture', 'Suture Techniques', 'Tendon Injuries', 'Time-to-Treatment', 'Treatment Outcome'] | 32,176,527 | [['A02.880.176'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.502'], ['C26.761'], ['E04.987.775'], ['C26.874'], ['E02.760.928', 'N02.421.585.928'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Metabolomic differentiation of deer antlers of various origins by 1H NMR spectrometry and principal components analysis. | The metabolomic analysis of various types of deer antler was performed by 1H NMR spectrometry and principal components analysis (PCA). The PCA of the 1H NMR spectra of the aqueous fractions allowed a clear discrimination between antler samples according to their origins by the first three principal components (PC1, PC2... | ['Animals', 'Antlers', 'Deer', 'Magnetic Resonance Spectroscopy', 'Protons'] | 16,495,028 | [['B01.050'], ['A13.507.288'], ['B01.050.150.900.649.313.500.380.373'], ['E05.196.867.519'], ['D01.248.497.300.459.700', 'D01.268.406.750', 'D01.362.340.750', 'G01.249.660.500']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells. | The interrelationship between platinum resistance and clinical response is not well established. The purpose of this study is to evaluate the expression of 14 genes involved in platinum resistance in a colon cancer cell line (HT29) and its oxaliplatin (OXA)-resistant sublines. Resistant cells exhibited lower expression... | ['Adenosine Triphosphatases', 'Antineoplastic Agents', 'Cation Transport Proteins', 'Cell Survival', 'Cisplatin', 'Colonic Neoplasms', 'Copper Sulfate', 'Copper-Transporting ATPases', 'DNA Repair Enzymes', 'Dose-Response Relationship, Drug', 'Drug Resistance, Neoplasm', 'Gene Expression Regulation, Neoplastic', 'Glutat... | 16,773,204 | [['D08.811.277.040.025'], ['D27.505.954.248'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['G04.346'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D01.875.800.80... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunocytochemical reactivity of rod and cone visual pigments in the sturgeon retina. | Microspectrophotometry and immunocytochemistry with several antivisual pigment antibodies were used to study visual cells of the Siberian sturgeon, Acipenser baeri Brandt. The retina contained rods and three morphological types of cones: large cones with oil drops, small cones with oil drops, and cone-like cells withou... | ['Animals', 'Antibodies, Monoclonal', 'Eye Proteins', 'Fishes', 'Immunoenzyme Techniques', 'Neural Pathways', 'Photoreceptor Cells', 'Retina', 'Retinal Pigments', 'Rod Opsins', 'Spectrophotometry'] | 1,534,023 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.306'], ['B01.050.150.900.493'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['A08.612'], ['A08.675.650.850.625', 'A08.675.650.915.937', 'A08.800.950.937', 'A09.371.729.831.625', 'A11.671... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Conserved and novel functions of programmed cellular senescence during vertebrate development. | Cellular senescence, a form of stable cell cycle arrest that is traditionally associated with tumour suppression, has been recently found to occur during mammalian development. Here, we show that cell senescence is an intrinsic part of the developmental programme in amphibians. Programmed senescence occurs in specific ... | ['Ambystoma mexicanum', 'Amphibians', 'Animals', 'Apoptosis Regulatory Proteins', 'Cellular Senescence', 'Embryo, Nonmammalian', 'Embryonic Development', 'Kidney', 'Organogenesis', 'Transforming Growth Factor beta', 'Vertebrates', 'Xenopus laevis'] | 27,888,193 | [['B01.050.150.900.090.608.080.068.525'], ['B01.050.150.900.090'], ['B01.050'], ['D12.644.360.075', 'D12.776.476.075'], ['G04.043'], ['A13.350', 'A16.331'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['A05.810.453'], ['G07.345.500.325.377', 'G08.686.784.170.450'], ['D12.644.276.374.687', 'D12.644.276.954.775', 'D1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serotonin syndrome caused by overdose with paroxetine and moclobemide. | Well known clinical syndromes can be produced by overdose with more commonly ingested substances such as opiates or tricyclic antidepressants. A case of a much more unusual syndrome presenting to the accident and emergency department resulting from overdose with a combination of tablets is reported. The clinical presen... | ['Adult', 'Benzamides', 'Disease-Free Survival', 'Drug Overdose', 'Emergency Treatment', 'Humans', 'Male', 'Moclobemide', 'Monoamine Oxidase Inhibitors', 'Paroxetine', 'Serotonin Syndrome', 'Serotonin Uptake Inhibitors', 'Suicide, Attempted'] | 10,417,944 | [['M01.060.116'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['C25.775.383', 'E02.319.306.500.500'], ['E02.365'], ['B01.050.150.900.649.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
No major effect of estrogen receptor beta gene RsaI polymorphism on bone mineral density and response to alendronate therapy in postmenopausal osteoporosis. | Genetic factors play an important role in the pathogenesis of osteoporosis. The genes involved are, however, still largely unknown. In the present study, we have investigated whether sequence variations in the estrogen receptor beta (ERbeta) gene are associated with bone mineral density (BMD) and biochemical markers of... | ['Adult', 'Alendronate', 'Amino Acids', 'Base Sequence', 'Bone Density', 'DNA Primers', 'Deoxyribonucleases, Type II Site-Specific', 'Estrogen Receptor beta', 'Female', 'Genotype', 'Humans', 'Middle Aged', 'Osteocalcin', 'Osteoporosis, Postmenopausal', 'Polymerase Chain Reaction', 'Polymorphism, Genetic', 'Receptors, E... | 12,137,804 | [['M01.060.116'], ['D02.705.429.500.100'], ['D12.125'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G11.427.100'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['D12.776.826.750.350.262'], ['G0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. | CONTEXT: Relatively little is known about genetic determinants of cognitive dysfunction in schizophrenia. Recent studies suggest that a brain-derived neurotrophic factor (BDNF) prodomain single nucleotide polymorphism resulting in a valine (Val)-to-methionine (Met) substitution is associated with impaired declarative m... | ['Adult', 'Brain', 'Brain Mapping', 'Brain-Derived Neurotrophic Factor', 'Cognition Disorders', 'Female', 'Genetic Variation', 'Genotype', 'Hippocampus', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Methionine', 'Neuropsychological Tests', 'Polymorphism, Genetic', 'Polymorphis... | 16,818,862 | [['M01.060.116'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['F03.615.250'], ['G05.365'], ['G05.380'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Intracellular assembly and transport of endogenous peptide-MHC class II complexes. | To define the intracellular site of assembly of endogenous peptide-MHC class II complexes, an immunochemical approach was undertaken employing a monoclonal antibody specific for an endogenous peptide-class II complex in combination with subcellular fractionation. Here, we show that newly synthesized MHC class II molecu... | ['Animals', 'Antibodies, Monoclonal', 'Antigen Presentation', 'Antigen-Presenting Cells', 'Cell Compartmentation', 'Cell Fractionation', 'Cell Line', 'Cell Membrane', 'Endosomes', 'Flow Cytometry', 'Histocompatibility Antigens Class II', 'Kinetics', 'Lysosomes', 'Mice', 'Models, Immunological', 'Peptides', 'Precipitin ... | 7,600,287 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.119', 'G12.450.050.400.070'], ['A11.066', 'A15.382.066'], ['G04.128'], ['E05.242.251'], ['A11.251.210'], ['A11.284.149'], ['A11.284.430.214.190.875.190.880.337'], ['E01.370.225.500.363.342', 'E01.370.225.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Using Veronikis ligature carrier to simplify transvaginal sacrospinous colpopexy. | BACKGROUND: Pelvic organ prolapse is a common problem in women and often requires surgical management. Sacrospinous colpopexy (SSC) requires significant expertise, especially in placement of the suture into sacrospinous ligament (SSL).METHODS: Veronikis ligature carrier (VLC) designed for SSC was used to facilitate sut... | ['Adult', 'Aged', 'Aged, 80 and over', 'Colposcopy', 'Female', 'Humans', 'Ligation', 'Middle Aged', 'Suture Techniques', 'Treatment Outcome', 'Uterine Prolapse', 'Vagina'] | 16,752,266 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.378.150', 'E01.370.388.250.150', 'E04.502.250.150', 'E04.520.150', 'E04.950.300.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.426'], ['M01.060.116.630'], ['E04.987.775'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enhancing safety in behavioral emergency situations. | The implementation of a behavioral emergency response team (BERT) at a large midwestern health care organization is described. The BERT is a resource supporting nurses and other health care staff in managing behavioral emergencies. The Joint Commission (2010) reported an increasing rate of violence by patients toward h... | ['Emergencies', 'Humans', 'Mental Disorders', 'Nursing Care', 'Occupational Health', 'Psychiatric Nursing', 'Violence', 'Workplace'] | 23,477,025 | [['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['E02.760.611', 'N02.421.533'], ['N01.400.525'], ['H02.478.676.710', 'N02.421.533.778'], ['I01.198.240.856', 'I01.880.735.900'], ['N01.824.245.925', 'N04.452.677.975']] | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Profound Finger Extension Weakness 21 Years After a Traumatic Lumbar Spine Pseudomeningocele. | BACKGROUND: We present a case report of traumatic pseudomeningocele and a review of the literature and discussion of the neuro-cytoarchitecture to address the disproportionate weakness of extensor neurons seen in the case.CASE DESCRIPTION: A 42-year old man developed profound hand weakness 21 years after a lumbar spina... | ['Adult', 'Cerebrospinal Fluid Shunts', 'Epidural Space', 'Fingers', 'Follow-Up Studies', 'Humans', 'Lumbar Vertebrae', 'Male', 'Meningocele', 'Muscle Weakness', 'Peritoneum', 'Spinal Fractures', 'Subarachnoid Space'] | 30,165,213 | [['M01.060.116'], ['E04.035.188', 'E04.525.170'], ['A02.835.232.834.803.350'], ['A01.378.800.667.430'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.834.519'], ['C10.500.680.598', 'C16.131.666.680.598', 'C23.300... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Medical cannabis: An oxymoron? Physicians' perceptions of medical cannabis. | BACKGROUND: Medical cannabis policies are changing in many places around the world, and physicians play a major role in the implementation of these policies. The aim of this study was to gain a deeper understanding of physicians' views on medical cannabis and its possible integration into their clinic, as well as to id... | ['Attitude of Health Personnel', 'Female', 'Humans', 'Male', 'Medical Marijuana', 'Narration', 'Physicians', 'Qualitative Research'] | 29,653,439 | [['F01.100.050', 'N05.300.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26.528'], ['E05.318.308.502', 'F01.145.209.459', 'L01.399.250.660', 'N05.715.360.300.480', 'N06.850.520.308.502'], ['M01.526.485.810', 'N02.360.810'], ['H01.770.644.241.850']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Ten-Year Trend in Women's Reasons for Abstaining or Limiting Drinking: The 2000 and 2010 United States National Alcohol Surveys. | BACKGROUND: Data on individual and cultural factors contributing to drinking can inform screening and brief intervention in clinical practice. Our aims were to examine 10-year trends in women's reasons for abstaining/limiting drinking and to document changes in associations with drinking status for population subgroups... | ['Adult', 'African Americans', 'Age Factors', 'Alcohol Drinking', 'Attitude to Health', 'Continental Population Groups', 'Cultural Characteristics', 'European Continental Ancestry Group', 'Female', 'Hispanic Americans', 'Humans', 'Logistic Models', 'Middle Aged', 'Religion', 'United States'] | 29,634,451 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.317.269'], ['F01.100.150', 'N05.300.150'], ['M01.686.508'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['M01.686.508.400'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives. | Klavuzon is a naphthalen-1-yl substituted á,â-unsaturated ä-lactone derivative, and is one of the anti-proliferative members of this class of compounds. Asymmetric and racemic syntheses of novel á,â-unsaturated ä-lactone derivatives are important to investigate their potential for the treatment of cancer. In this study... | ['Antineoplastic Agents', 'Cell Line, Tumor', 'Cell Proliferation', 'DNA Topoisomerases, Type I', 'Humans', 'Lactones', 'Neoplasms', 'Structure-Activity Relationship', 'Topoisomerase I Inhibitors'] | 28,242,062 | [['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.399.403.483', 'D12.776.157.687.375', 'D12.776.660.720.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.540'], ['C04'], ['G02.111.830', 'G07.690.773.997'], ['D27.505.519.389.892.500', 'D27.505.954... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcranial Doppler sonography as a diagnostic tool in vascular dementia. | Transcranial Doppler monitoring of the flow velocity at the level of the middle cerebral artery was performed in 40 demented patients, 20 with multi-infarct dementia (MID) and 20 with senile dementia of the Alzheimer type (SDAT), and in 25 age-matched controls. The following conditions were evaluated: (1) rest; (2) 60 ... | ['Aged', 'Alzheimer Disease', 'Cerebrovascular Circulation', 'Dementia, Vascular', 'Humans', 'Middle Aged', 'Ultrasonography'] | 2,187,699 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['G09.330.100.159'], ['C10.228.140.300.400', 'C10.228.140.300.510.800.500', 'C10.228.140.380.230', 'C10.228.140.695.500', 'C14.907.137.126.372.500', 'C14.907.253.560.350.500', 'F03.615.400.350'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Post-traumatic stress disorder and functioning and quality of life outcomes in female Vietnam veterans. | OBJECTIVE: This investigation assessed whether current post-traumatic stress disorder (PTSD) was associated with impaired functioning in a nationally representative sample of female Vietnam veterans.METHODS: Logistic models were used to determine the association between PTSD and outcome while adjusting for demographic ... | ['Activities of Daily Living', 'Adult', 'Female', 'Humans', 'Logistic Models', 'Male', 'Odds Ratio', 'Quality of Life', 'Stress Disorders, Post-Traumatic', 'Surveys and Questionnaires', 'United States', 'Veterans', 'Vietnam', "Women's Health"] | 9,339,077 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Humanities [K]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Estrogen binding sites in hamster white adipose tissue: sex- and site-related variations; modulation by testosterone. | Estrogen binding sites (ER) were studied, using 17 beta-[3H]estradiol as the ligand, in epididymal or parametrial and subcutaneous adipose tissues of male and female hamsters. Compared with other mammalian fat deposits, intact male and female hamsters possess abundant estrogen binding sites with moderate affinity for e... | ['Adipose Tissue', 'Animals', 'Binding Sites', 'Binding, Competitive', 'Carrier Proteins', 'Cricetinae', 'Cytosol', 'Female', 'Immunoassay', 'Indicators and Reagents', 'Kinetics', 'Male', 'Mesocricetus', 'Organ Specificity', 'Receptors, Estrogen', 'Sex Characteristics', 'Testosterone', 'Up-Regulation'] | 8,582,599 | [['A10.165.114'], ['B01.050'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D12.776.157'], ['B01.050.150.900.649.313.992.635.075.250'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['E05.478.566', 'E05.601.470'], ['D27.720.470.410'], ['G01.374.661', 'G02.111.49... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Evaluation of early MR imaging of the liver in rabbits after ethanol injection]. | Seven days after ethanol injection, MR images of the liver in 5 rabbits were evaluated by T1, T2-weighted SE and TURBO-FLASH dynamic images. Necrotic area was visualized as low-intensity on T1-weighted images and high-intensity on T2-weighted images. These findings were similar to the tumor that was not treated, so it ... | ['Animals', 'Ethanol', 'Injections', 'Liver', 'Magnetic Resonance Imaging', 'Necrosis', 'Rabbits'] | 8,488,107 | [['B01.050'], ['D02.033.375'], ['E02.319.267.530'], ['A03.620'], ['E01.370.350.825.500'], ['C23.550.717'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevention and treatment of hormone-associated venous thromboembolism: a patient management approach. | Given the known increased risk of venous thromboembolism (VTE) associated with both oral contraceptive (OC) use and hormone replacement therapy (HRT), it is important to address questions about the prevention and management of hormone-associated VTE. Specifically, the objectives of this article are as follows: (1) to p... | ['Anticoagulants', 'Clinical Trials as Topic', 'Contraceptives, Oral', 'Female', 'Hormone Replacement Therapy', 'Humans', 'Thrombophilia', 'Venous Thromboembolism'] | 20,659,653 | [['D27.505.954.502.119'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['E02.319.452'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.925'], ['C14.907.355.590.700']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Complications of heparin-induced thrombocytopenia. | Four cases are presented which are believed to represent thrombocytopenia associated with intravascular thrombosis and vascular occlusion in patients receiving heparin. Patients with gangrene all had pre-existing arterial disease and arterial insufficiency. Such venous and arterial thromboses are paradoxic and unpredic... | ['Adult', 'Aged', 'Dose-Response Relationship, Drug', 'Heparin', 'Humans', 'Male', 'Middle Aged', 'Phlebitis', 'Platelet Count', 'Prothrombin Time', 'Thrombocytopenia', 'Thrombosis'] | 7,081,832 | [['M01.060.116'], ['M01.060.116.100'], ['G07.690.773.875', 'G07.690.936.500'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.907.617.718', 'C14.907.940.740'], ['E01.370.225.500.195.107.740', 'E01.370.225.625.107.700', 'E01.370.225.625.625.625', 'E05.200.500.195.107.740... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Key influences on the professional socialisation and practice of students undertaking different pre-registration nurse education programmes in the United Kingdom. | A principal aim of pre-registration nurse education programmes is the process of effective socialisation of students into the professional role. Key influences on the professional socialisation and practice of students undertaking such programmes were explored using a semi-structured interview approach (N = 99). This w... | ['Curriculum', 'Education, Nursing, Baccalaureate', 'Humans', 'Organizational Culture', 'Social Identification', 'Socialization', 'United Kingdom'] | 8,886,901 | [['I02.158'], ['I02.358.462.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.606'], ['F01.145.813.708'], ['I01.880.853.934'], ['Z01.542.363']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Advanced age negatively influences mesenteric lymph node T cell responses after burn injury. | While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged m... | ['Age Factors', 'Animals', 'Burns', 'Female', 'Interferon-gamma', 'Interleukin-2', 'Interleukin-4', 'Lymph Nodes', 'Mesentery', 'Mice', 'Mice, Inbred BALB C', 'T-Lymphocytes'] | 12,644,320 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['C26.200'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D1... | ['Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Adipose angiotensinogen secretion, blood pressure, and AGT M235T polymorphism in obese patients. | OBJECTIVE: To investigate AGT secretion in cultured adipocytes from obese patients and its relationship with obesity-related phenotypes, blood pressure, and the M235T polymorphism in the AGT gene.RESEARCH METHODS AND PROCEDURES: Measurements, including anthropometry, body composition (DXA), and blood pressure, were per... | ['Abdomen', 'Adipocytes', 'Adult', 'Angiotensinogen', 'Biopsy', 'Blood Pressure', 'Body Composition', 'Cell Size', 'Cells, Cultured', 'Female', 'Genotype', 'Humans', 'Middle Aged', 'Obesity', 'Polymerase Chain Reaction', 'Polymorphism, Genetic', 'Polymorphism, Restriction Fragment Length'] | 15,044,674 | [['A01.923.047'], ['A11.329.114'], ['M01.060.116'], ['D12.644.456.073.070', 'D12.644.861.020', 'D12.776.811.070', 'D12.776.872.020'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.600.875.249', 'G09.330.380.076'],... | ['Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Desiccation tolerance among different isolates of the entomopathogenic nematode Steinernema feltiae (Fillipjev). | Poor storage capacity is a major constraint limiting further expansion of the use of entomopathogenic nematodes. In order to prolong shelf life, a quiescent state of the dauer juveniles (DJs) should be induced. This can be attained by means of desiccation of DJs. In this study, 24 natural isolations of Steinernema felt... | ['Animals', 'Dehydration', 'Moths', 'Pest Control, Biological', 'Rhabditida', 'Water'] | 22,696,940 | [['B01.050'], ['C18.452.950.179', 'C23.550.274'], ['B01.050.500.131.617.720.500.500.937.650'], ['N06.850.780.200.650.650'], ['B01.050.500.500.294.400.875'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. | Wnt proteins bind to seven-transmembrane Frizzled receptors to mediate the important developmental, morphogenetic, and stem cell related tissue-regenerative effects of Wnt signaling. Dysregulated Wnt signaling is associated with many cancers. Currently, there are no drug candidates or even tool compounds that modulate ... | ['Animals', 'Antinematodal Agents', 'Cell Line', 'Cell Line, Tumor', 'Endocytosis', 'Frizzled Receptors', 'Green Fluorescent Proteins', 'Humans', 'Microscopy, Confocal', 'Niclosamide', 'Rats', 'Signal Transduction', 'Wnt Proteins', 'beta Catenin'] | 19,772,353 | [['B01.050'], ['D27.505.954.122.250.075.080'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.417'], ['D12.776.543.750.695.017', 'D12.776.543.750.850.500'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.395', 'E05.595.395'], ['D02.065.199.860.470', 'D02.065.793.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Axon guidance of rat cortical neurons by microcontact printed gradients. | Substrate-bound gradients expressed in numerous spatio-temporal patterns play a crucial role during the development of complex neural circuits. A deeper understanding of the axon guidance mechanism is provided by studying the effect of a defined substrate-bound cue on a confined neural network. In this study, we constr... | ['Animals', 'Axons', 'Cell Culture Techniques', 'Cell Movement', 'Cells, Cultured', 'Cerebral Cortex', 'Embryo, Mammalian', 'Laminin', 'Materials Testing', 'Neurites', 'Neurons', 'Polylysine', 'Printing', 'Rats', 'Rats, Wistar', 'Surface Properties'] | 21,167,596 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.198', 'G07.568.500.180'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['A16.254'], ['D12.776.395.550.530', 'D12.776.543.550.500', 'D12.776.860.300... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
How do I implement a more restrictive transfusion trigger of hemoglobin level of 7 g/dL at my hospital? | BACKGROUND: The red blood cell (RBC) transfusion trigger is a major driver of transfusion practice and affects health care costs and in some instances patient outcomes. Reducing the transfusion threshold will decrease RBC utilization and hospital costs.STUDY DESIGN AND METHODS: The hospital transfusion committee, endor... | ['Erythrocyte Transfusion', 'Hemoglobins', 'Hospitals', 'Humans'] | 25,573,208 | [['E02.095.135.140.275'], ['D12.776.124.400', 'D12.776.422.316.762'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with ò receptors. | Sigma receptors are small membrane proteins implicated in a number of pathophysiological conditions, including drug addiction, psychosis, and cancer; thus, small molecule inhibitors of sigma receptors have been proposed as potential pharmacotherapeutics for these diseases. We previously discovered that endogenous monoc... | ['Amines', 'Animals', 'Cell Line, Tumor', 'Guinea Pigs', 'HEK293 Cells', 'Humans', 'Ligands', 'Liver', 'Nitrophenols', 'Protein Binding', 'Protein Interaction Mapping', 'Rats', 'Receptors, sigma'] | 21,790,129 | [['D02.092'], ['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.992.550'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['A03.620'], ['D02.455.426.559.389.657.566', 'D02.640.743'], ['G02.111.679', 'G03.808'], ['E05.601.690'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Racial and socioeconomic disparities in reduction mammoplasty: an analysis of nationwide inpatient sample database. | The American Society of Plastic Surgery recently recorded a decline in numbers of breast reductions, one of the most common procedures performed by plastic surgeons. The purpose of this study is to characterize the reduction mammoplasty patient population which would further assist in planning the future workforce need... | ['Adult', 'African Americans', 'Breast', 'Cohort Studies', 'Databases, Factual', 'Ethnic Groups', 'European Continental Ancestry Group', 'Female', 'Healthcare Disparities', 'Hispanic Americans', 'Humans', 'Hypertrophy', 'Incidence', 'Insurance Coverage', 'Mammaplasty', 'Retrospective Studies', 'Risk Assessment', 'Socio... | 21,451,367 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['A01.236'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['M01.686.754', 'N01.224.317'], ['M01.686.508.400'], ['N04.590.374.380', 'N05.300.493'], ['M01.686.754.441'], ['B0... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Metabolic Fate of 13 | The present study introduces a novel triple-phase (liquids, solids, and gases) approach, which employed uniformly labeled [U-13C] polydextrose (PDX) for the selective profiling of metabolites generated from dietary fiber fermentation in an in vitro colon simulator using human fecal inocula. Employing 13C NMR spectrosco... | ['Anaerobiosis', 'Bioreactors', 'Biotransformation', 'Carbon Isotopes', 'Colon', 'Dietary Fiber', 'Erysipelothrix', 'Ethanol', 'Fatty Acids, Volatile', 'Feces', 'Fermentation', 'Formates', 'Gastrointestinal Microbiome', 'Glucans', 'Humans', 'Lactic Acid', 'Magnetic Resonance Spectroscopy', 'Metabolome', 'Microbial Cons... | 29,359,944 | [['G02.111.062', 'G03.078'], ['E07.115', 'J01.897.120.115'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D01.268.150.075', 'D01.496.123'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D09.301.416', 'G07.203.300.400', 'J02.500.400'], ['B03.353.688', 'B03.510.460.400.410.350'], ['D02.033.375'], ['D10.251.400'],... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The Arabidopsis thaliana response regulator ARR22 is a putative AHP phospho-histidine phosphatase expressed in the chalaza of developing seeds. | BACKGROUND: The Arabidopsis response regulator 22 (ARR22) is one of two members of a recently defined novel group of two-component system (TCS) elements. TCSs are stimulus perception and response modules of prokaryotic origin, which signal by a His-to-Asp phosphorelay mechanism. In plants, TCS regulators are involved i... | ['Arabidopsis', 'Arabidopsis Proteins', 'Cytoplasm', 'Fungal Proteins', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Genetic Complementation Test', 'Phenotype', 'Phosphorylation', 'Phosphotransferases', 'Plants, Genetically Modified', 'Protein Binding', 'Seeds', 'Signal Transductio... | 18,625,081 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['A11.284.430.214'], ['D12.776.354'], ['G05.308.310'], ['G05.308.375'], ['E05.393.281.526'], ['G05.695'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D08.811.913.696'], ['B01.650.520', 'B05.620.600'], ['G02.111.679', 'G03.808'], ['A18.024.500.750', 'G07.20... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Using a community-based participatory research approach to improve the performance capacity of local health departments: the Kansas Immunization Technology Project. | BACKGROUND: Building the capacity of local health departments (LHDs) in the use of health data is critical. Unlike community-based health agencies or private healthcare providers, LHDs serve as public health officials for their communities. Thus, LHDs' ability to use technology, electronically access and distribute up-... | ['Adult', 'Community Health Services', 'Community-Based Participatory Research', 'Curriculum', 'Education, Public Health Professional', 'Efficiency, Organizational', 'Female', 'Health Care Surveys', 'Humans', 'Immunization Programs', 'Kansas', 'Male', 'Middle Aged', 'Models, Theoretical', 'Patient Acceptance of Health ... | 18,587,634 | [['M01.060.116'], ['N02.421.143'], ['H01.770.644.193', 'N05.425.104'], ['I02.158'], ['I02.358.556'], ['N04.452.209.500'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.608'], ['Z01.107.567.8... | ['Named Groups [M]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects on the tumor specific growth factor and tumor necrosis factor á in rats' precancerous lesion of primary hepatocellular carcinoma by direct moxibustion at Ganshu (BL 18) acupoint. | OBJECTIVE: To investigate the effect of direct moxibustion at Ganshu (BL18) on the serum concentrations of tumor specific growth factor (TSGF) and tumor necrosis factor á (TNF-á) in a rat model with precancerous lesion of primary hepatocellular carcinoma (HCC), so as to explore the mechanism of moxibustion underlying i... | ['Acupuncture Points', 'Animals', 'Carcinoma, Hepatocellular', 'Liver Neoplasms', 'Male', 'Moxibustion', 'Neoplasm Proteins', 'Precancerous Conditions', 'Rats, Wistar', 'Tumor Necrosis Factor-alpha'] | 26,264,572 | [['E02.190.044.555.035'], ['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E02.190.044.588'], ['D12.776.624'], ['C04.834'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.644.276.374.500.800', 'D12.644.276... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hsa-microRNA-181a is a regulator of a number of cancer genes and a biomarker for endometrial carcinoma in patients: a bioinformatic and clinical study and the therapeutic implication. | The aberrant expression of human microRNA-181a-1 (hsa-miR-181a) has been implicated in the pathogenesis of various cancers, serving as an oncogene or a tumor suppressor. However, the role of hsa-miR-181a in the pathogenesis of endometrial carcinoma (EC) and its clinical significance are unclear. This study aimed to sea... | ['Algorithms', 'Biomarkers, Tumor', 'Computational Biology', 'Endometrial Neoplasms', 'Female', 'Humans', 'MicroRNAs'] | 25,733,820 | [['G17.035', 'L01.224.050'], ['D23.101.140'], ['H01.158.273.180', 'L01.313.124'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Risky alcohol use predicts temporal mismatch negativity impairments in young people with bipolar disorder. | Alcohol misuse in bipolar disorder (BD) has a negative impact on illness progression. The NMDA/glutamatergic system is implicated in BD pathophysiology and is critically involved in the effects of alcohol on the brain. Mismatch negativity (MMN) is purported to reflect NMDA receptor output, providing a measure for inves... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Analysis of Variance', 'Bipolar Disorder', 'Chi-Square Distribution', 'Electroencephalography', 'Evoked Potentials', 'Female', 'Humans', 'Male', 'Neuropsychological Tests', 'Regression Analysis', 'Risk', 'Young Adult'] | 24,594,113 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F03.084.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Airborne Asbestos Exposures from Warm Air Heating Systems in Schools. | The aim of this study was to investigate the concentrations of airborne asbestos that can be released into classrooms of schools that have amosite-containing asbestos insulation board (AIB) in the ceiling plenum or other spaces, particularly where there is forced recirculation of air as part of a warm air heating syste... | ['Air Pollutants', 'Asbestos, Amosite', 'Environmental Monitoring', 'Heating', 'Humans', 'Inhalation Exposure', 'Microscopy, Electron, Transmission', 'Microscopy, Phase-Contrast', 'Occupational Exposure', 'Risk Assessment', 'Schools'] | 26,311,718 | [['D27.888.284.101'], ['D01.524.500.040', 'D01.578.725.050.050.050', 'D01.578.725.500.040', 'D01.837.725.700.760.070.050.060', 'D01.837.725.700.760.535.040'], ['N06.850.460.350.080', 'N06.850.780.375'], ['N06.230.150.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.112'], ['E01.370.350.515.402.... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Effect of various sterilization methods on the bioactivity of laser ablation pseudowollastonite coating. | Sterilization is required for using any material or device in contact with the human body. The aim of this work was to investigate the effect of four sterilization methods (steam autoclave, hydrogen peroxide plasma, ethylene oxide, and gamma sterilization) on the surface chemistry and in vitro bioactivity of pseudowoll... | ['Body Fluids', 'Calcium Compounds', 'Coated Materials, Biocompatible', 'Durapatite', 'Ethylene Oxide', 'Gamma Rays', 'Humans', 'Hydrogen Peroxide', 'Lasers', 'Materials Testing', 'Models, Biological', 'Silicates', 'Steam', 'Sterilization'] | 20,578,226 | [['A12.207'], ['D01.146'], ['D25.130.420', 'J01.637.051.130.420'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['D02.355.291.411.417'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['B01.050.150.900.649.313.988.4... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A controlled prospective study of the effect of endurance training on the recurrence rate of myocardial infarction. A description of the experimental design. | A multicenter prospective study has been designed to determine whether participation in an exercise program which produces a significant training effect will affect the recurrence rate in men who have survived an initial myocardial infarction. The control group consists of subjects who participate in a program involvin... | ['Angina Pectoris', 'Exercise Therapy', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Occupations', 'Personality', 'Prospective Studies', 'Recurrence', 'Research Design'] | 1,200,020 | [['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['N01.824.547'],... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
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