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Design, synthesis, and biological activities of novel azole-bonded â-hydroxypropyl oxime O-ethers. | The synthesis and biological effects of 15 novel azole-bonded â-hydroxypropyl oxime O-ethers have been described. In this synthesis, the oximation of aromatic ketones followed by an O-alkylation reaction with epichlorohydrin and/or epibromohydrin led to the corresponding O-oxime ether adducts. Subsequently, the attaine... | ['Antifungal Agents', 'Azoles', 'Bacterial Proteins', 'Catalytic Domain', 'Drug Design', 'Ethers', 'Models, Molecular', 'Molecular Docking Simulation', 'Molecular Structure', 'Oximes', 'Structure-Activity Relationship'] | 25,081,563 | [['D27.505.954.122.136'], ['D03.383.129'], ['D12.776.097'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D02.355'], ['E05.599.595'], ['E05.599.595.249', 'L01.224.160.249'], ['G02.111.570', 'G02.466'], ['D02.092.570.665'], ['G02.111.830'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis. | BACKGROUND: Gene silencing through CpG island hypermethylation is a major mechanism in cancer development. In the present study, we aimed to identify and validate novel target genes inactivated through promoter hypermethylation in colorectal tumor development.METHODS: With the use of microarrays, the gene expression pr... | ['ADAM Proteins', 'ADAMTS1 Protein', 'Cell Line, Tumor', 'Colorectal Neoplasms', 'CpG Islands', 'DNA Methylation', 'Epigenesis, Genetic', 'Gene Expression Regulation, Neoplastic', 'Genes, Neoplasm', 'Humans', 'Microarray Analysis', 'Promoter Regions, Genetic', 'Receptors, Glucocorticoid', 'Receptors, Retinoic Acid', 'S... | 17,167,179 | [['D08.811.277.656.675.374.102', 'D09.400.430.500', 'D12.776.395.033'], ['D08.811.277.656.675.374.102.500.500', 'D09.400.430.500.500.500', 'D12.776.395.033.500.500', 'D12.776.860.300.085.500'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Rat ovarian function after post or prenatal injection of clomiphen]. | If newborn rats are subcutaneously injected with 0,075--0,100 mg of Clomiphene Citrate within the first 5 days, it results that 73.7% of the females remain anovulatory. The percentage rises to 100 if 0,125--0,400 mg are given in several injections. The identical treatment has no influence on the testicular function. Pr... | ['Abortion, Veterinary', 'Abscess', 'Amnion', 'Animals', 'Animals, Newborn', 'Clomiphene', 'Female', 'Fetal Resorption', 'Injections, Subcutaneous', 'Male', 'Ovarian Diseases', 'Pregnancy', 'Rats'] | 1,227,833 | [['C13.703.039.422', 'C22.021'], ['C01.830.025', 'C23.550.470.756.100'], ['A10.615.284.277', 'A16.254.750.277'], ['B01.050'], ['B01.050.050.282'], ['D02.455.426.559.389.150.700.125'], ['C13.703.223.300', 'C23.550.260.585.260'], ['E02.319.267.530.620'], ['C13.351.500.056.630', 'C19.391.630'], ['G08.686.784.769'], ['B01.... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glycyrrhetinic acid prevents acetaminophen-induced acute liver injury via the inhibition of CYP2E1 expression and HMGB1-TLR4 signal activation in mice. | Acetaminophen (APAP) is a widely used antipyretic and analgesic drug, which is safe and effective at the therapeutic dose. Unfortunately, excessive dosage of APAP could cause severe liver injury due to lack of effective therapy. Successful therapeutic strategies are urgently requested in clinic. Glycyrrhetinic acid (GA... | ['Acetaminophen', 'Animals', 'Anti-Inflammatory Agents', 'Cells, Cultured', 'Chemical and Drug Induced Liver Injury', 'Cytochrome P-450 CYP2E1', 'Down-Regulation', 'Glycyrrhetinic Acid', 'Glycyrrhiza', 'HMGB1 Protein', 'Hepatocytes', 'Humans', 'Interleukin-1beta', 'Liver', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Signal... | 28,668,488 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['B01.050'], ['D27.505.954.158'], ['A11.251'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['D08.244.453.491.375', 'D08.811.682.662.582.338', 'D08.811.682.690.708.170.450.375', 'D12.776.422.220.453.491.375'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro transport of carbon in the trachea of veal calves. | Carbon transport was studied in vitro in preparations of trachea and bronchus from veal calves. The mean velocity varied from 4.2 mm/min in the main bronchi to 6.3 mm/min in the ventral trachea. In some locations no transport was observed. Stereomicroscopic evaluation of Alcian blue-phloxine stained mucosal surfaces re... | ['Age Factors', 'Animals', 'Bronchi', 'Carbon', 'Cattle', 'In Vitro Techniques', 'Mucociliary Clearance', 'Mucous Membrane', 'Trachea'] | 8,009,822 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['A04.411.125'], ['D01.268.150'], ['B01.050.150.900.649.313.500.380.271'], ['E05.481'], ['E01.370.386.520', 'G09.772.555'], ['A10.615.550'], ['A04.889']] | ['Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Impact of ocean acidification on the early development and escape behavior of marine medaka (Oryzias melastigma). | Ocean acidification is predicted to affect a wide diversity of marine organisms. However, no studies have reported the effects of ocean acidification on Indian Ocean fish. We have used the Indian Ocean medaka (Oryzias melastigma) as a model species for a marine fish that lives in coastal waters. We investigated the imp... | ['Animals', 'Behavior, Animal', 'Carbon Dioxide', 'Environmental Monitoring', 'Global Warming', 'Hydrogen-Ion Concentration', 'Indian Ocean', 'Larva', 'Oryzias', 'Seawater'] | 28,923,289 | [['B01.050'], ['F01.145.113'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.175.374.500'], ['G02.300'], ['Z01.756.342'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.150.900.493.850.139.650'], ['G16.500.275.725.500']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The effect of a specific histidine-rich glycoprotein polymorphism on male infertility and semen parameters. | In women, there is evidence that a single nucleotide polymorphism (SNP) in the histidine-rich glycoprotein (HRG) named HRG C633T is relevant for a number of fertility outcomes including recurrent miscarriage, ovarian response and pregnancy outcome after IVF. This case-control study was designed to investigate whether t... | ['Abortion, Habitual', 'Adult', 'Alleles', 'Female', 'Fertilization in Vitro', 'Genotype', 'Homozygote', 'Humans', 'Infertility, Male', 'Male', 'Polymorphism, Single Nucleotide', 'Pregnancy', 'Pregnancy Outcome', 'Pregnancy Rate', 'Proteins', 'Semen', 'Sperm Count'] | 27,210,772 | [['C13.703.039.089'], ['M01.060.116'], ['G05.360.340.024.340.030'], ['E02.875.800.750', 'E05.820.800.750'], ['G05.380'], ['G05.380.554'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['G05.365.795.598'], ['G08.686.784.769'], ['E01.789.700', 'G08.686.784.769.496'], ['E05.318.308.985.775', 'G08.6... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intracellular differentiation of Leishmania amazonensis promastigotes to amastigotes: presence of megasomes, cysteine proteinase activity and susceptibility to leucine-methyl ester. | Intracellular differentiation of Leishmania promastigotes to amastigotes is a critical step in the establishment of infection. In this report three related features of mexicana subspecies amastigotes were used to follow the differentiation of the parasites within macrophages. Early after infection, (a) parasites did no... | ['Animals', 'Cells, Cultured', 'Cysteine Endopeptidases', 'Electrophoresis, Polyacrylamide Gel', 'Female', 'Leishmania', 'Leishmaniasis', 'Leucine', 'Macrophages', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Microscopy, Electron'] | 2,235,078 | [['B01.050'], ['A11.251'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.268.475.868.488'], ['C01.610.752.300.500', 'C01.610.858.560', 'C01.920.813', 'C17.800.838.775.560'], ['D12.125.070.637', 'D12.125.142.441'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The new combined antituberculous drug: the original combined antituberculous drug dioxazid]. | The new combined antituberculous drug dioxazid was designed on the basis on the synergism of isoniazid and dioxidine. The dosage form of the drug is a lyophilized powder (containing dioxidine, 100 mg, and isoniazid, 250 mg) in flasks. Its activity and toxicity were tested in an experiment on laboratory animals. Clinica... | ['Animals', 'Antitubercular Agents', 'Drug Combinations', 'Female', 'Isoniazid', 'Male', 'Mycobacterium tuberculosis', 'Quinoxalines', 'Rats', 'Tuberculosis, Pulmonary'] | 17,500,222 | [['B01.050'], ['D27.505.954.122.085.255'], ['D26.310'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['D03.633.100.857'], ['B01.050.150.900.649.313.992.635.505.700'], ['C01.150.252.410.040.552.846.899', 'C01.748.939', 'C08.381.922', 'C08.730.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Three-dimensional virtual model of the human temporal bone: a stand-alone, downloadable teaching tool. | OBJECTIVE: To develop a three-dimensional virtual model of a human temporal bone based on serial histologic sections.BACKGROUND: The three-dimensional anatomy of the human temporal bone is complex, and learning it is a challenge for students in basic science and in clinical medicine.METHODS: Every fifth histologic sect... | ['Adolescent', 'Anatomy, Cross-Sectional', 'Cochlea', 'Ear Canal', 'Ear, Middle', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Male', 'Models, Anatomic', 'Teaching', 'Temporal Bone', 'Tympanic Membrane', 'Vestibule, Labyrinth'] | 16,791,035 | [['M01.060.057'], ['H01.158.100.185'], ['A09.246.300.246'], ['A09.246.272.396'], ['A09.246.397'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129'], ['I02.903'], ['A02.835.232.781.885'], ['A09.246.272.702'], [... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
Age-related neurochemical and behavioural changes in D409V/WT GBA1 mouse: Relevance to lewy body dementia. | Heterozygous mutations in GBA1, the gene which encodes the lysosomal enzyme glucocerebrosidase (GCase), are a strong genetic risk factor for the development of Lewy body dementia (LBD). Until this point however, recapitulation of the symptoms and pathology of LBD has been limited to a homozygous GBA1 mouse model which ... | ['Animals', 'Cerebral Cortex', 'Cognition Disorders', 'Disease Models, Animal', 'Exploratory Behavior', 'Gliosis', 'Glucosylceramidase', 'Glucosylceramides', 'Glycosphingolipids', 'Heterozygote', 'Hippocampus', 'Lewy Body Disease', 'Lysosomes', 'Male', 'Maze Learning', 'Mice', 'Mice, Inbred C57BL', 'Mutation, Missense'... | 31,299,418 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['F03.615.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['F01.145.387', 'F01.658.370'], ['C23.550.369'], ['D08.811.277.450.420.412'], ['D02.065.313.250.490', 'D09.400.410.420.525.200.250.490', 'D10.390.470.675.200.250.490', 'D10.570.877.360.612.200.250.490'], ['D09... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dissolution kinetics of paracetamol single crystals. | The dissolution anisotropy of paracetamol crystals grown in the presence and absence of the molecularly similar additive, p-acetoxyacetanilide (PAA) was studied under controlled conditions using a single crystal dissolution method in undersaturated aqueous solutions. Linear dissolution rates were determined for all the... | ['Acetaminophen', 'Crystallization', 'Kinetics', 'Solubility', 'Tomography, X-Ray'] | 11,996,808 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['E05.196.300', 'G02.171'], ['G01.374.661', 'G02.111.490'], ['G02.805'], ['E01.370.350.700.810', 'E01.370.350.825.810']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of pregnancy and sex steroids on alpha 1-adrenoceptor mechanisms in the guinea-pig uterine vascular bed. | Adrenoceptor mechanisms in the extrinsic uterine arteries from late pregnant guinea-pigs were characterized pharmacologically and compared with contractile responses of uterine arteries from non-pregnant and oophorectomized control, progesterone and oestrogen treated animals. Pregnancy caused an increase in diameter of... | ['Animals', 'Cocaine', 'Dose-Response Relationship, Drug', 'Female', 'Gonadal Steroid Hormones', 'Guinea Pigs', 'Isoproterenol', 'Norepinephrine', 'Normetanephrine', 'Potassium', 'Prazosin', 'Pregnancy', 'Pregnancy, Animal', 'Receptors, Adrenergic, alpha', 'Uterine Contraction', 'Uterus', 'Yohimbine'] | 2,853,340 | [['B01.050'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['G07.690.773.875', 'G07.690.936.500'], ['D06.472.334.851'], ['B01.050.150.900.649.313.992.550'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['D02.033.10... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cathepsin A activity in primary and metastatic human melanocytic tumors. | Several lysosomal proteases including cathepsins B, D, H and L have been found to play a role in the metastasis of tumor cells. However, up to now no information on the role of cathepsin A, a lysosomal multifunctional peptidase, in the proliferative, invasive, and metastatic potential of malignant tumors has been avail... | ['Carboxypeptidases', 'Cathepsin A', 'Humans', 'Melanoma'] | 10,749,558 | [['D08.811.277.656.350.245'], ['D08.811.277.656.224.062', 'D08.811.277.656.350.245.260', 'D08.811.277.656.959.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Individualized developmental care for very-low-birth-weight premature infants. | Forty very-low-birth-weight neonatal intensive care unit (NICU) infants with birth weights < or = 1,250 g were randomly assigned to treatment or control groups. Behavior of the treatment infants was systematically evaluated, and individualized developmentally oriented care plans were implemented to enhance stability. T... | ['Hospital Charges', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Infant, Very Low Birth Weight', 'Intensive Care, Neonatal', 'Length of Stay', 'Treatment Outcome'] | 8,591,679 | [['N03.219.262.300', 'N03.219.442.613'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['M01.060.703.520.460.600'], ['E02.760.190.405', 'N02.421.585.190.500'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Switching of á-Catenin From Epithelial to Neuronal Type During Lens Epithelial Cell Differentiation. | Purpose: Ocular lens fiber cell elongation, differentiation, and compaction are associated with extensive reorganization of cell adhesive interactions and cytoskeleton; however, our knowledge of proteins critical to these events is still evolving. This study characterizes the distribution pattern of neuronal-specific á... | ['Animals', 'Catenins', 'Cell Differentiation', 'Epithelial Cells', 'Humans', 'Immunoblotting', 'Lens, Crystalline', 'Mass Spectrometry', 'Membrane Proteins', 'Mice', 'Reverse Transcriptase Polymerase Chain Reaction'] | 28,692,740 | [['B01.050'], ['D12.776.220.145'], ['G04.152'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['A09.371.060.500'], ['E05.196.566'], ['D12.776.543'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.620.500.725']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thymic carcinoma with primary spine metastasis. | Thymic carcinomas (TC) are rare tumors, representing 0.2% to 1.5% of all malignancies, with extrathoracic metastases to liver, kidney and bone occurring in 1% to 15% of patients. Although TC exhibit highly aggressive biological behavior, spinal metastasis with cord compression is rare. We describe a 57-year-old man wit... | ['Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Spinal Cord Compression', 'Spinal Neoplasms', 'Thymoma', 'Thymus Neoplasms'] | 21,435,886 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.228.854.761', 'C26.819.678'], ['C04.588.149.828', 'C05.116.231.828', 'C05.116.900.801'], ['C04.557.435.850', 'C04.588.894.949.500', 'C15.604.861.800'], ['C04.588.894.949', 'C15.604.861']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sexually transmitted diseases in women--something can be done! | Women with sexually transmitted diseases (STDs) are largely asymptomatic, and even in the presence of symptoms are frequently misdiagnosed. The "stigma of VD" perpetuates this problem, such that both patient and physician are too embarrassed to suggest appropriate STD diagnostic tests. Imperatives for the reduction of ... | ['Advertising', 'Chlamydia Infections', 'Education, Medical, Continuing', 'Female', 'Financing, Government', 'Gonorrhea', 'Herpes Simplex', 'Humans', 'Male', 'Mass Screening', 'Sexually Transmitted Diseases', 'United States'] | 6,894,271 | [['J01.219.687.274', 'L01.143.050'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.500.711.281.301'], ['I02.358.212.350', 'I02.358.399.250'], ['N03.219.521.346'], ['C01.150.252.400.625.275', 'C01.150.252.734.401', 'C01.221.812.281.401', 'C01... | ['Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
Stress sources in nursing practice. Evolution during nursing training. | A cohort study was carried out in order to evaluate the evolution of nursing students' perception of stressors associated with clinical practice. Sixty-nine students answered the KEZKAK questionnaire about nursing stressors [Zupiria X., Uranga M.J., Alberdi, M.J., Barandiaran, M., 2003b. Kezkak: cuestionario biling?e d... | ['Adult', 'Attitude of Health Personnel', 'Burnout, Professional', 'Clinical Competence', 'Education, Nursing, Baccalaureate', 'Emotions', 'Empathy', 'Female', 'Health Services Needs and Demand', 'Humans', 'Internal-External Control', 'Male', 'Nurse-Patient Relations', 'Nursing Education Research', 'Nursing Methodology... | 17,187,905 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.358.462.316'], ['F01.470'], ['F01.752.355', 'F01.752.543.500.500'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Process... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Training: an integral adjunct to the introduction of newer methods of fertility regulation. | The provision of new technologies of fertility control that are known to be safer, simpler, and more effective may at first result in higher complication rates, particularly if training in the new techniques is inadequate. This was illustrated by analysis of data on several fertility control methods collected by the In... | ['Allied Health Personnel', 'Contraception', 'Education, Medical, Continuing', 'Humans', 'Internship and Residency'] | 25,802 | [['M01.526.485.067', 'N02.360.067'], ['E02.875.194'], ['I02.358.212.350', 'I02.358.399.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750']] | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
EMG biofeedback in stroke: effect of patient characteristics. | Forty-eight upper and 44 lower extremities of 52 stroke patients were treated using a clinical emg biofeedback training approach. The age, sex, hemiparetic side, duration of stroke or previous rehabilitation, and number of biofeedback training sessions had no significant relationship to treatment outcomes. Lower extrem... | ['Adolescent', 'Adult', 'Aged', 'Aphasia', 'Arm', 'Biofeedback, Psychology', 'Cerebrovascular Disorders', 'Electromyography', 'Female', 'Humans', 'Leg', 'Male', 'Middle Aged', 'Outcome and Process Assessment, Health Care', 'Proprioception'] | 485,806 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of nitrotyrosine antibodies and development of immunoassays for the detection of nitrated proteins. | Three monoclonal antibodies (mAb) and three polyclonal antibodies (pAb) have been characterized and compared with respect to their cross-reactivities and affinities for 3-nitrotyrosine, eight aromatic compounds with similar chemical structures, a peptide containing a single nitrotyrosine residue, and fourteen nitrated ... | ['Air Pollutants', 'Animals', 'Antibodies', 'Antibodies, Monoclonal', 'Environmental Monitoring', 'Goats', 'Immunoassay', 'Mice', 'Rabbits', 'Sheep', 'Tyrosine'] | 15,213,824 | [['D27.888.284.101'], ['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.500.380.513'], ['E05.478.566', 'E05.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prediction of dental caries in pre-school children. | Data obtained in a longitudinal study of caries incidence and caries-related factors were analysed with a view to producing a model for the prediction of caries. In direct correlations, caries incidence was significantly associated with bacterial, dietary and salivary variables; but when the data were examined by stepw... | ['Child', 'Child, Preschool', 'Colony Count, Microbial', 'DMF Index', 'Dental Caries', 'Dental Caries Activity Tests', 'Dietary Carbohydrates', 'Female', 'Forecasting', 'Humans', 'Hydrogen-Ion Concentration', 'Iceland', 'Incidence', 'Lactobacillus', 'Longitudinal Studies', 'Male', 'Prevalence', 'Saliva', 'Streptococcus... | 8,242,681 | [['M01.060.406'], ['M01.060.406.448'], ['E01.370.225.875.220', 'E05.200.875.220'], ['E05.318.308.980.438.300.350', 'E06.208.266', 'N05.715.360.300.800.438.300.340', 'N06.850.520.308.980.438.300.350', 'N06.890.160.100'], ['C07.793.720.210'], ['E06.342.250'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['I01.320'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geograp... | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[A woman with swelling and blue-red discolouration of the leg]. | A 61-year-old woman presented with a sudden marked swelling and blue-red discolouration of her entire left leg. The diagnosis phlegmasia cerulea dolens was made. This is an extreme case of lower-extremity deep venous thrombosis that can cause critical limb ischaemia and possible limb loss. | ['Diagnosis, Differential', 'Female', 'Humans', 'Leg', 'Middle Aged', 'Thrombophlebitis', 'Venous Thrombosis'] | 29,473,538 | [['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['M01.060.116.630'], ['C14.907.355.830.925.770', 'C14.907.617.718.788', 'C14.907.940.740.910'], ['C14.907.355.830.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Phosphorus supply influences heathland responses to atmospheric nitrogen deposition. | On an upland moor dominated by pioneer Calluna vulgaris and with an understorey of mosses and lichens, experimental plots were treated with factorial combinations of nitrogen (N) at +0 and +20kg Nha(-1)yr(-1), and phosphorus (P) at +0 and +5kg Pha(-1)yr(-1). Over the 4-year duration of the experiment, the cover of the ... | ['Air Pollutants', 'Bryophyta', 'Calluna', 'Ecology', 'Ecosystem', 'Environmental Monitoring', 'Fertilizers', 'Geography', 'Lichens', 'Nitrogen', 'Phosphorus', 'Time', 'United Kingdom'] | 17,182,158 | [['D27.888.284.101'], ['B01.650.940.800.575.137'], ['B01.650.940.800.575.912.250.341.937.211'], ['H01.158.273.248', 'H01.277.249'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.720.031.400'], ['H01.277.500'], ['B01.300.340', 'B05.350'], ['D01.268.604', 'D01.362.625'], ['D01.268.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Adjunctive treatment of abdominal catastrophes and sepsis with direct peritoneal resuscitation: indications for use in acute care surgery. | BACKGROUND: The success of damage-control surgery (DCS) for the treatment of trauma has led to its use in other surgical problems such as abdominal sepsis. Previous studies using direct peritoneal resuscitation (DPR) for the treatment of trauma have yielded promising results. We present the results of the application o... | ['APACHE', 'Abdominal Injuries', 'Abdominal Wound Closure Techniques', 'Female', 'Humans', 'Male', 'Middle Aged', 'Peritoneal Lavage', 'Propensity Score', 'Resuscitation', 'Sepsis'] | 25,159,241 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['C26.017'], ['E04.987.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.927.705'], ['E05.318.740.600.675', 'N05.715.360.750.625... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High sensitivity C-reactive protein associated with different health predictors in middle-aged and oldest old Chinese. | OBJECTIVE: To describe the distribution of plasma high sensitivity C-reactive protein (hsCRP) and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China.METHODS: 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selecte... | ['Adult', 'Aged, 80 and over', 'Aging', 'Asian Continental Ancestry Group', 'Biomarkers', 'C-Reactive Protein', 'China', 'Cross-Sectional Studies', 'Female', 'Humans', 'Longevity', 'Male', 'Middle Aged', 'Models, Biological'] | 22,840,575 | [['M01.060.116'], ['M01.060.116.100.080'], ['G07.345.124'], ['M01.686.508.200'], ['D23.101'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['Z01.252.474.164'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.345.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Protective effect of oxiracetam on traumatic brain injury in rats]. | OBJECTIVE: To study the role of oxiracetam on traumatic brain injury in rats.METHODS: Thirty Wistar rats were randomly divided into 3 groups: sham operation group, model group and treatment group. Feeney method were used to establish traumatic brain injury (TBI) model in rats in model and treatment group, and rats in s... | ['Animals', 'Brain Injuries', 'Male', 'Maze Learning', 'Pyrrolidines', 'Rats', 'Rats, Wistar'] | 24,175,546 | [['B01.050'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['F02.463.425.874.500'], ['D03.383.773'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900']] | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Community-level impact of the reproductive health vouchers programme on service utilization in Kenya. | This paper examines community-level association between exposure to the reproductive health vouchers programme in Kenya and utilization of services. The data are from a household survey conducted among 2527 women (15-49 years) from voucher and comparable non-voucher sites. Analysis entails cross-tabulations with Chi-sq... | ['Adolescent', 'Adult', 'Delivery, Obstetric', 'Female', 'Financing, Government', 'Health Care Surveys', 'Humans', 'Kenya', 'Maternal Health Services', 'Middle Aged', 'Poverty', 'Pregnancy', 'Residence Characteristics', 'Young Adult'] | 22,492,923 | [['M01.060.057'], ['M01.060.116'], ['E04.520.252'], ['N03.219.521.346'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.120.400'], ['N02.421.143.620', 'N02.421.800.500'], ['M01.060.116.630'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Identification of Root-Secreted Compounds Involved in the Communication Between Cucumber, the Beneficial Bacillus amyloliquefaciens, and the Soil-Borne Pathogen Fusarium oxysporum. | Colonization of plant growth-promoting rhizobacteria (PGPR) is critical for exerting their beneficial effects on the plant. Root exudation is a major factor influencing the colonization of both PGPR and soil-borne pathogens within the root system. However, the tripartite interaction of PGPR, plant roots, and soil-borne... | ['Bacillus amyloliquefaciens', 'Colony Count, Microbial', 'Cucumis sativus', 'Disease Resistance', 'Fusarium', 'Gas Chromatography-Mass Spectrometry', 'Genes, Plant', 'Phytochemicals', 'Plant Exudates', 'Plant Roots', 'Soil Microbiology', 'Transcription, Genetic'] | 27,937,752 | [['B03.300.390.400.158.218.076', 'B03.353.500.100.218.076', 'B03.510.100.100.218.076', 'B03.510.415.400.158.218.076', 'B03.510.460.410.158.218.076'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B01.650.940.800.575.912.250.300.188.666'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['B01.3... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of exercise training on pulmonary mechanics and functional status in patients with prolonged mechanical ventilation. | BACKGROUND: The functional status and outcomes in patients with prolonged mechanical ventilation (PMV) are often limited by poor endurance and pulmonary mechanics, which result from the primary diseases or prolonged time bedridden. We evaluate the impact of exercise training on pulmonary mechanics, physical functional... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Exercise', 'Female', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Recovery of Function', 'Respiration, Artificial', 'Respiratory Insufficiency', 'Respiratory Mechanics', 'Survival Rate', 'Tidal Volume', 'Time Factors', 'Treatment Outcome'] | 22,152,978 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G11.427.410.698.277', 'I03.350'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G16.757'], ['E02.041.625', 'E02.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Calcified parenchymal central nervous system cysticercosis and clinical outcomes in epilepsy. | OBJECTIVE: This study aimed to compare clinical outcomes including seizure frequency and psychiatric symptoms between patients with epilepsy with neuroimaging evidence of past brain parenchymal neurocysticercosis infection, patients with other structural brain lesions, and patients without structural neuroimaging abnor... | ['Adult', 'Calcinosis', 'Cross-Sectional Studies', 'Depression', 'Epilepsy', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Neurocysticercosis', 'Neuroimaging', 'Prevalence', 'Retrospective Studies', 'Seizures', 'Treatment Outcome'] | 25,569,744 | [['M01.060.116'], ['C18.452.174.130'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['C01.207.205.250.550', 'C01.610.105.250.550', 'C01.610.335.190.902.185.550', 'C1... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice. | The haemagglutinin (HA) of H1N1 and H3N2 influenza A virus (IAV) subtypes has to be activated by host proteases. Previous studies showed that H1N1 virus cannot replicate efficiently in Tmprss2-/- knock-out mice whereas H3N2 viruses are able to replicate to the same levels in Tmprss2-/- as in wild type (WT) mice. Here, ... | ['Amino Acid Substitution', 'Animals', 'Cloning, Molecular', 'Dogs', 'Gene Expression Regulation, Viral', 'Hemagglutinins', 'Influenza A virus', 'Madin Darby Canine Kidney Cells', 'Mice', 'Mice, Knockout', 'Models, Molecular', 'Mutagenesis', 'Orthomyxoviridae Infections', 'Protein Conformation', 'Serine Endopeptidases'... | 30,084,768 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['E05.393.220'], ['B01.050.150.900.649.313.750.250.216.200'], ['G05.308.385'], ['D27.505.696.477.136.377'], ['B04.820.480.968.405.400'], ['A11.251.210.827', 'A11.436.589'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Heparin coating of vascular prostheses reduces thromboemboli. | BACKGROUND: Synthetic conduits made from currently available materials are suboptimal for use in small-diameter vascular reconstruction because of their high surface thrombogenicity, which leads to failure.METHODS: In this study control, heparin-irrigated, or heparin-bonded expanded polytetrafluoroethylene (ePTFE) graf... | ['Animals', 'Blood Vessel Prosthesis', 'Blood Vessel Prosthesis Implantation', 'Equipment Design', 'Heparin', 'Male', 'Microcirculation', 'Muscle, Skeletal', 'Polytetrafluoroethylene', 'Rats', 'Thromboembolism', 'Thrombosis'] | 9,369,888 | [['B01.050'], ['E07.695.110'], ['E04.100.814.868.500', 'E04.650.200'], ['E05.320'], ['D09.698.373.400'], ['G09.330.100.645'], ['A02.633.567', 'A10.690.552.500'], ['D05.750.395.616', 'D25.720.395.616', 'J01.637.051.720.395.616'], ['B01.050.150.900.649.313.992.635.505.700'], ['C14.907.355.590'], ['C14.907.355.830']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Expression of focal adhesion kinase in patients with endometrial cancer: a clinicopathologic study. | INTRODUCTION: The pp125 focal adhesion kinase (FAK) plays a pivotal role in tumor cell signaling. Focal adhesion kinase expression has been linked to tumor cell proliferation, invasion, and metastasis, but data on endometrial cancer are inconclusive.METHODS: We assess FAK expression by immunohistochemistry in endometri... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Carcinoma', 'Cohort Studies', 'Disease Progression', 'Endometrial Neoplasms', 'Female', 'Focal Adhesion Kinase 1', 'Humans', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Staging', 'Survival Analysis'] | 19,823,058 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.557.470.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.550.291.656'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['D08.811.913.696.620.682.725.049.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Structure-strength relations in mammalian tendon. | The stress-strain relations in mammalian tendon are analyzed in terms of the structure and mechanics of its constituents. The model considers the tensile and bending strength of the collagen fibers, the tensile strength of the elastin fibers, and the interaction between the matrix and the collagen fibers. The stress-st... | ['Animals', 'Biomechanical Phenomena', 'Collagen', 'Elastin', 'Mathematics', 'Models, Biological', 'Rats', 'Stress, Mechanical', 'Tendons'] | 728,528 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D05.750.078.421', 'D12.776.860.300.350'], ['H01.548'], ['E05.599.395'], ['B01.050.150.900.649.313.992.635.505.700'], ['G01.374.835'], ['A02.880']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Accurate bone segmentation in 2D radiographs using fully automatic shape model matching based on regression-voting. | Recent work has shown that using Random Forests (RFs) to vote for the optimal position of model feature points leads to robust and accurate shape model matching. This paper applies RF regression-voting as part of a fully automatic shape model matching (FASMM) system to three different radiograph segmentation problems: ... | ['Algorithms', 'Bone and Bones', 'Computer Simulation', 'Humans', 'Models, Biological', 'Models, Statistical', 'Osteoarthritis, Knee', 'Pattern Recognition, Automated', 'Radiographic Image Enhancement', 'Radiographic Image Interpretation, Computer-Assisted', 'Regression Analysis', 'Reproducibility of Results', 'Sensiti... | 24,579,139 | [['G17.035', 'L01.224.050'], ['A02.835.232', 'A10.165.265'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['C05.550.114.606.500', 'C05.799.613.500'], ['L01.399.750'], ['E01.370.350.600.350.700', 'E01.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Association of Tooth Loss With Development of Swallowing Problems in Community-Dwelling Independent Elderly Population: The Fujiwara-kyo Study. | BACKGROUND: Tooth loss induces changes to the anatomy of the oral cavity. We hypothesized that tooth loss may disturb smooth swallowing in healthy elderly people. The purpose of this study was to investigate the effect of tooth loss on the development of swallowing problems in an independent elderly population.METHODS:... | ['Aged', 'Aged, 80 and over', 'Deglutition Disorders', 'Female', 'Humans', 'Independent Living', 'Japan', 'Male', 'Prospective Studies', 'Tooth Loss'] | 26,341,784 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C06.405.117.119', 'C09.775.174'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.050.500', 'N01.224.791.550', 'N06.850.505.400.800.550'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Inhibition of angiotensin-1-converting enzyme activity by two varieties of ginger (Zingiber officinale) in rats fed a high cholesterol diet. | Angiotensin-1-converting enzyme (ACE) inhibitors are widely used in the treatment of cardiovascular diseases. This study sought to investigate the inhibitory effect of two varieties of ginger (Zingiber officinale) commonly consumed in Nigeria on ACE activity in rats fed a high cholesterol diet. The inhibition of ACE ac... | ['Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Atherosclerosis', 'Cholesterol', 'Ginger', 'Humans', 'Male', 'Malondialdehyde', 'Peptidyl-Dipeptidase A', 'Plant Extracts', 'Rats', 'Rats, Wistar', 'Triglycerides'] | 24,433,069 | [['D27.505.519.389.745.085'], ['B01.050'], ['C14.907.137.126.307'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['B01.650.940.800.575.912.250.618.937.900.444'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.047.700'], ['D08.811.277.656.350.350.687'], ['D20.215.784.500', 'D26.667'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Paraoxonase and arylesterase activities in children with iron deficiency anemia and vitamin B12 deficiency anemia. | Paraoxonase-1 is an esterase enzyme and it has 3 types of activity, namely paraoxonase, arylesterase, and diazoxonase. It has been reported that paraoxonase-1 deficiency is related to increased susceptibility to development of atherosclerosis and cardiovascular disease. The aim of this study was to investigate serum pa... | ['Anemia, Iron-Deficiency', 'Aryldialkylphosphatase', 'Carboxylic Ester Hydrolases', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Iron', 'Male', 'Vitamin B 12', 'Vitamin B 12 Deficiency', 'Vitamin B Complex'] | 22,568,797 | [['C15.378.071.196.300', 'C18.452.565.100'], ['D08.811.277.352.660.500'], ['D08.811.277.352.100'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D03.383.129.578.840.437.777', 'D03.633.400.909.437.777',... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Helical CT with multiplanar and three-dimensional reconstruction of nonneoplastic abnormalities of the trachea. | Helical CT is being increasingly used for the evaluation of suspected tracheal diseases. Although nonneoplastic and noninfectious diseases of the trachea are rare, their appearance on CT images may be highly suggestive of the diagnosis. High quality multiplanar and 3D reconstructions including 3D surface-shaded display... | ['Adult', 'Aged', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed', 'Tracheal Diseases'] | 11,351,190 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['C08.907']] | ['Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Synthesis and application of a 5'-aldehyde phosphoramidite for covalent attachment of DNA to biomolecules. | We recently reported the use of covalently attached DNA as a structural constraint for rational control of macromolecular conformation. Reductive amination was employed to attach each strand of the duplex DNA constraint to RNA, utilizing an aldehyde tethered to the 5'-terminus of the DNA. Here we describe the synthesis... | ['Aldehydes', 'Amines', 'DNA', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Organophosphorus Compounds', 'RNA'] | 16,839,163 | [['D02.047'], ['D02.092'], ['D13.444.308'], ['G02.111.570', 'G02.466'], ['E05.196.867.519.550'], ['D02.705'], ['D13.444.735']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lethality of a tritiated amino acid in early mouse embryos. | 2- to 4-cell and morula- to blastocyst-stage mouse embryos were cultured for 1 h in tritiated leucine at two specific activities and their subsequent development followed in vitro and in vivo (after transfer to recipients), respectively. 2- to 4-cell embryos that incorporated an average of 42 d.p.m. per embryo were imp... | ['Animals', 'Blastocyst', 'Culture Techniques', 'Embryo Transfer', 'Embryonic and Fetal Development', 'Fetal Proteins', 'Leucine', 'Mice', 'Morula', 'Tritium'] | 4,078,530 | [['B01.050'], ['A16.254.500'], ['E05.481.500'], ['E02.875.800.500', 'E05.820.800.500'], ['G07.345.500.325', 'G08.686.784.170'], ['D12.776.320'], ['D12.125.070.637', 'D12.125.142.441'], ['B01.050.150.900.649.313.992.635.505.500'], ['A16.615'], ['D01.268.406.875', 'D01.362.340.875', 'D01.496.749.925']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment-related improvement in neuropsychological functioning in suicidal depressed patients: paroxetine vs. bupropion. | Neuropsychological dysfunction is associated with risk for suicidal behavior, but it is unknown if antidepressant medication treatment is effective in reducing this dysfunction, or if specific medications might be more beneficial. A comprehensive neuropsychological battery was administered at baseline and after 8 weeks... | ['Adult', 'Antidepressive Agents, Second-Generation', 'Bupropion', 'Cognition Disorders', 'Depressive Disorder, Major', 'Double-Blind Method', 'Female', 'Humans', 'Male', 'Middle Aged', 'Paroxetine', 'Suicidal Ideation', 'Suicide, Attempted', 'Treatment Outcome'] | 25,555,415 | [['M01.060.116'], ['D27.505.954.427.700.122.050'], ['D02.522.818.110'], ['F03.615.250'], ['F03.600.300.375'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.383.621.600'], ['F01.145.126.980.875.149', 'I01.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Restoration of the airway following bilateral recurrent laryngeal nerve paralysis. | Bilateral recurrent laryngeal nerve paralysis has been treated by a number of ingenious techniques that include arytenoidectomies, vocal cord lateralizations, cordectomies, and, recently, reinnervation procedures and laser arytenoidectomies. An arytenoidectomy is recommended by a thyrotomy approach without lateralizati... | ['Arytenoid Cartilage', 'Female', 'Humans', 'Intubation, Intratracheal', 'Laryngeal Cartilages', 'Male', 'Postoperative Period', 'Vocal Cord Paralysis', 'Vocal Cords', 'Voice Quality'] | 4,046,705 | [['A02.165.257.625.083', 'A02.165.407.500.083', 'A04.329.591.085'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['A02.165.257.625', 'A02.165.407.500', 'A04.329.591'], ['E04.614.750', 'N02.421.585.753.750'], ['C08.360.931', 'C09.400.931', 'C10.292.887.800', 'C10.597.62... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Abdominal cocoon: sonographic features. | An abdominal cocoon is a rare condition in which the small bowel is encased in a membrane. The diagnosis is usually established at surgery. Here we describe the sonographic features of this condition. | ['Adolescent', 'Diagnosis, Differential', 'Female', 'Hernia', 'Humans', 'Intestinal Obstruction', 'Intestine, Small', 'Ultrasonography'] | 12,862,272 | [['M01.060.057'], ['E01.171'], ['C23.300.707'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531'], ['A03.556.124.684'], ['E01.370.350.850']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy. | Telomerase expression represents a good target for cancer gene therapy. The promoters of the core telomerase catalytic [human telomerase reverse transcriptase (hTERT)] and RNA [human telomerase RNA (hTR)] subunits show selective activity in cancer cells but not in normal cells. This property can be harnessed to express... | ['Adenocarcinoma', 'Carcinoma', 'Cell Line, Tumor', 'DNA-Binding Proteins', 'Female', 'Genetic Therapy', 'Humans', 'Neoplasms', 'Promoter Regions, Genetic', 'Recombinant Proteins', 'Telomerase', 'Transcription, Genetic', 'Transfection', 'Urinary Bladder Neoplasms'] | 16,331,888 | [['C04.557.470.200.025'], ['C04.557.470.200'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.260'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D12.776.828'], ['D08.811.913.696.... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell context-dependent dual effects of EFEMP1 stabilizes subpopulation equilibrium in responding to changes of in vivo growth environment. | Conflicting functions of EFEMP1 in cancer have been reported. Using two syngeneic glioma cell lines (U251 and U251-NS) carrying two different principal cell subpopulations that express high or low EGFR, and that are able to interconvert via mis-segregation of chromosome 7 (Chr7), we studied EFEMP1's cell-context-depend... | ['Animals', 'Apoptosis', 'Blotting, Western', 'Brain Neoplasms', 'Cell Proliferation', 'ErbB Receptors', 'Extracellular Matrix Proteins', 'Female', 'Glioma', 'Humans', 'Immunoenzyme Techniques', 'In Situ Hybridization, Fluorescence', 'Mice', 'Mice, Nude', 'RNA, Messenger', 'Real-Time Polymerase Chain Reaction', 'Recept... | 26,307,682 | [['B01.050'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peer Victimization in Adolescents With Severe Obesity: The Roles of Self-Worth and Social Support in Associations With Psychosocial Adjustment. | Objective: To examine the associations of peer victimization with internalizing symptoms, externalizing symptoms, social competence, and academic performance in a clinical sample of adolescents with severe obesity, and whether self-worth and social support affect these associations.Methods: Multisite cross-sectional da... | ['Adaptation, Psychological', 'Adolescent', 'Adolescent Behavior', 'Bullying', 'Crime Victims', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Obesity, Morbid', 'Peer Group', 'Self Concept', 'Self Report', 'Social Adjustment', 'Social Support'] | 27,680,082 | [['F01.058'], ['M01.060.057'], ['F01.145.022'], ['F01.145.126.125.550', 'F01.145.813.213.500', 'I01.880.735.070'], ['M01.135'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Functional scanning electron microscopical observations on the oral roof in an air-breathing teleost, Clarias batrachus (LINN.). | Scanning Electron Microscopical (SEM) as well as light microscopical features of the oral roof including barbels of the air-breathing teleost, Clarias batrachus (LINN.) have been described in relation to its feeding habit. 3 distinct types of taste buds have been recorded for the first time in the barbels, lip, and in ... | ['Animals', 'Cheek', 'Epithelium', 'Fishes', 'Lip', 'Microscopy, Electron, Scanning', 'Mouth Mucosa', 'Pharynx', 'Taste Buds', 'Tooth'] | 3,743,999 | [['B01.050'], ['A01.456.505.173', 'A14.194'], ['A10.272'], ['B01.050.150.900.493'], ['A01.456.505.631.515', 'A14.549.336'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A10.615.550.599', 'A14.549.512'], ['A03.556.750', 'A04.623', 'A14.724'], ['A03.556.500.885.779', 'A08.675.650.915.500.800', 'A08.800.950.500.800',... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of aflatoxin Q1 in urine by automated immunoaffinity column clean-up and liquid chromatography. | A liquid chromatographic system with an automated clean-up procedure for aflatoxin Q1 in human urine is described. The samples were cleaned up by using immunoaffinity columns originally designed for aflatoxin M1. The chromatographic system was a C18 column with an acidic mobile phase of acetonitrile-water containing po... | ['Aflatoxin M1', 'Aflatoxins', 'Autoanalysis', 'Chromatography, Affinity', 'Chromatography, High Pressure Liquid', 'Cross Reactions', 'Humans', 'Immunoassay', 'Reference Standards', 'Spectrometry, Fluorescence'] | 7,987,484 | [['D03.383.663.283.119.100', 'D03.633.100.150.119.100', 'D23.946.587.142.100'], ['D03.383.663.283.119', 'D03.633.100.150.119', 'D23.946.587.142'], ['E05.059'], ['E05.196.181.400.170'], ['E05.196.181.400.300'], ['G12.122.281'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566', 'E05.601.470'], ['E05.978.80... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Dorsal dislocation of the proximal interphalangeal joints of the finger. Results after static and functional treatment]. | In a follow-up examination of 30 patients who had sustained dorsal dislocations of the PIP joint, the results of two conservative therapy regimens, either immobilisation or early motion were investigated. In Group A, 15 patients were treated by closed reduction and immobilisation with a forearm cast for four weeks. Nin... | ['Adult', 'Casts, Surgical', 'Female', 'Finger Injuries', 'Finger Joint', 'Humans', 'Male', 'Postoperative Complications', 'Radiography', 'Range of Motion, Articular', 'Retrospective Studies', 'Splints'] | 11,468,899 | [['M01.060.116'], ['E07.858.442.660.430.500', 'E07.858.690.725.430.500'], ['C26.448.429'], ['A02.835.583.405.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767'], ['E01.370.350.700'], ['E01.370.600.700', 'G11.427.760'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Temperature-dependent dielectric properties of liver tissue measured during thermal ablation: toward an improved numerical model. | The development of microwave tumor ablation devices depends largely on numerical simulations of antenna characteristics and transient electromagnetic heating. However, without an adequate tissue model simulation predictions can vary widely from experimental results. In this study, tissue dielectric properties are measu... | ['Animals', 'Body Temperature', 'Computer Simulation', 'Electric Impedance', 'Hyperthermia, Induced', 'In Vitro Techniques', 'Liver', 'Microwaves', 'Models, Biological', 'Surgery, Computer-Assisted', 'Swine'] | 19,162,635 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['L01.224.160'], ['G01.358.500.249.277.350'], ['E02.565'], ['E05.481'], ['A03.620'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['E05.599.395'], ['E04.749'], ['B01.050.150.900.649.313.500.880']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ethno-cultural variations in the experience and meaning of mental illness and treatment: implications for access and utilization. | We conducted a study to investigate how understandings of mental illness and responses to mental health services vary along ethno-racial lines. Participants were 25 African American, Latino, and Euro-American inner-city residents in Hartford Connecticut diagnosed with severe mental illness and currently enrolled in a l... | ['Adult', 'African Americans', 'Cross-Cultural Comparison', 'Emigrants and Immigrants', 'European Continental Ancestry Group', 'Female', 'Health Services Accessibility', 'Hispanic Americans', 'Humans', 'Male', 'Mental Disorders', 'Mental Health Services', 'Middle Aged', 'Narration', 'Patient Acceptance of Health Care',... | 20,603,387 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['M01.189'], ['M01.686.508.400'], ['N04.590.374.350', 'N05.300.430'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F04.408', 'N02.421.461'], ['M01.060.116.630'], ['E05.318.30... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Influence of folk medicine on the family practitioner. | The practice of folk medicine in the United States is increasing. Awareness by the family practitioner is essential in order to effectively communicate and successfully recommend medical treatment to those patients who hold belief in these traditional practices. Root medicine is particularly thriving in the southeaster... | ['Adult', 'Attitude of Health Personnel', 'Family Practice', 'Female', 'Humans', 'Medicine, Traditional', 'Patients', 'Physician-Patient Relations', 'Phytotherapy', 'Refugees', 'United States'] | 3,810,218 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.488', 'I01.076.201.450.654'], ['M01.643'], ['F01.829.401.650.675', 'N05.300.660.625'], ['E02.190.755'], ['M01.755'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
High body fat and low muscle mass are associated with increased arterial stiffness in Asian Indians in North India. | AIM: To investigate the associations of high body fat and low muscle mass with arterial stiffness in Asian Indians with type 2 diabetes mellitus (T2DM) in North India.METHODS: In this cross sectional study, subjects with T2DM (males n=110, females n=58, mean age: 53.8±10.0years) were recruited. Anthropometry and body c... | ['Adipose Tissue', 'Asian Continental Ancestry Group', 'Body Mass Index', 'Cross-Sectional Studies', 'Diabetes Mellitus, Type 2', 'Female', 'Humans', 'Incidence', 'India', 'Male', 'Middle Aged', 'Muscle, Skeletal', 'Muscular Atrophy', 'Obesity', 'Organ Size', 'Retrospective Studies', 'Risk Assessment', 'Severity of Ill... | 25,200,813 | [['A10.165.114'], ['M01.686.508.200'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C18.452.394.750.149', 'C19.246.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.5... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
P2Y11 impairs cell proliferation by induction of cell cycle arrest and sensitizes endothelial cells to cisplatin-induced cell death. | Extracellular ATP mediates a wide range of physiological effects, including cell proliferation, differentiation, maturation, and migration. However, the effect of ATP on cell proliferation has been contradictory, and the mechanism is not fully understood. In the current study, we found that extracellular ATP significan... | ['Adenosine Triphosphate', 'Antineoplastic Agents', 'Aorta', 'Apoptosis', 'Cell Cycle Checkpoints', 'Cell Proliferation', 'Cells, Cultured', 'Cisplatin', 'Down-Regulation', 'Drug Synergism', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'MAP Kinase Signaling System', 'Neovascularization, Physiologic', 'Primary Ce... | 21,503,959 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D27.505.954.248'], ['A07.015.114.056'], ['G04.146.954.035'], ['G04.144.109'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G07.690... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Chronic myelocytic leukemia associated with cytomegalovirus induced sialoadenitis after unrelated allogeneic bone marrow transplantation]. | A 26-year-old male with chronic myelocytic leukemia was admitted for unrelated allogeneic bone marrow transplantation (BMT). After BMT, he developed swelling of biateral submandibular glands accompanied with pneumonitis possibly due to cytomegalovirus (CMV). Biopsy from the left submandibular gland showed giant cells w... | ['Adult', 'Antiviral Agents', 'Bone Marrow Transplantation', 'Cytomegalovirus Infections', 'Ganciclovir', 'Humans', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Lung Diseases, Interstitial', 'Male', 'Postoperative Complications', 'Sialadenitis'] | 8,683,867 | [['M01.060.116'], ['D27.505.954.122.388'], ['E02.095.147.725.040', 'E04.936.580.040'], ['C01.925.256.466.245'], ['D03.633.100.759.758.399.454.250.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.250', 'C15.378.190.636.370'], ['C08.381.483'], ['C23.550.767'], ['C07.465.815.793']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
ABO-Nonidentical Liver Transplantation in the United States. | Under the United Network for Organ Sharing (UNOS) policy, deceased donor livers may be offered to ABO-nonidentical candidates at each given Model for End-Stage Liver Disease (MELD) score and to blood type B candidates at MELD ?30. To evaluate ABO-nonidentical liver transplantation (LT) in the United States, we examined... | ['ABO Blood-Group System', 'Adult', 'Blood Group Incompatibility', 'Female', 'Graft Survival', 'Humans', 'Liver Transplantation', 'Male', 'Middle Aged', 'Patient Selection', 'Time Factors', 'Tissue Donors', 'Tissue and Organ Procurement', 'United States', 'Waiting Lists'] | 26,932,134 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['M01.060.116'], ['G09.188.114', 'G12.186'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['M01.060.116.630'], ['E05.581.500.653', 'N04.590.731'], ['G01.910.857'], ['M0... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[The diagnosis and treatment of pulmonary tuberculosis combined with chronic bronchitis in middle-aged and elderly subjects]. | Investigation of patients 60 years of age and older with different clinical forms of pulmonary tuberculosis revealed chronic bronchitis in 76-80%, obstructive bronchitis--in 1/3 of all cases. The diagnosis of chronic bronchitis in most cases is established on the basis of clinico-roentgenological and functional examina... | ['Aged', 'Aged, 80 and over', 'Antitubercular Agents', 'Bronchitis', 'Bronchodilator Agents', 'Chronic Disease', 'Drug Therapy, Combination', 'Female', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Tuberculosis, Pulmonary'] | 2,617,985 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085.255'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['C23.550.291.500'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production. | Vascular smooth muscle cell (VSMC) proliferation is pivotal in the progression of hypertension, atherosclerosis, and restenosis. Resveratrol is a grape polyphenol that is implicated as an important contributor to red wine's vascular protective effects. Its antimitogenic action on VSMC is attributed to an array of pleio... | ['Animals', 'Antioxidants', 'Aorta', 'Apoptosis', 'Biopterin', 'Cell Cycle', 'Cell Proliferation', 'DNA', 'Dose-Response Relationship, Drug', 'Female', 'Guanosine Triphosphate', 'Male', 'Muscle, Smooth, Vascular', 'Nitric Oxide', 'Nitric Oxide Synthase Type II', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Estrogen', 'R... | 17,666,920 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A07.015.114.056'], ['G04.146.954.035'], ['D03.633.100.733.631.202', 'D08.211.090'], ['G04.144'], ['G04.161.750', 'G07.345.249.410.750'], ['D13.444.308'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.633.100.759.646.454.504', 'D13.695.667.45... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo monitoring of pancreatic beta-cells in a transgenic mouse model. | We generated a transgenic mouse model (RIP-luc) for the in vivo monitoring of pancreatic islet mass and function in response to metabolic disease. Using the rat insulin promoter fused to firefly luciferase, and noninvasive technology to detect luciferase activity, we tracked changes in reporter signal during metabolic ... | ['Animals', 'Diabetes Mellitus, Experimental', 'Female', 'Genes, Reporter', 'Insulin', 'Insulin Secretion', 'Insulin-Secreting Cells', 'Luciferases', 'Luminescent Measurements', 'Male', 'Mice', 'Mice, Transgenic', 'Nuclear Proteins', 'Obesity', 'Promoter Regions, Genetic', 'Ribosomal Proteins'] | 16,954,020 | [['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G05.360.340.024.340.435'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G03.442', 'G07.475'], ['A03.734.414.131', 'A06.300.414.087', 'A06.390.131', 'A11.382.625.092', 'A11.436.294.092'], ['D08.811.682.517', 'D12.776.532.510'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improvements in personal resiliency among youth who have completed trauma-focused cognitive behavioral therapy: A preliminary examination. | This preliminary investigation assessed whether different aspects of personal resiliency improved for youth (7-17 years old) impacted by child sexual abuse (CSA) after completing trauma-focused cognitive behavioral therapy (TF-CBT). The Resiliency Scales for Children and Adolescents (RSCA; Prince-Embury, 2007) were adm... | ['Adolescent', 'Anxiety', 'Caregivers', 'Child', 'Child Abuse, Sexual', 'Cognitive Behavioral Therapy', 'Depression', 'Female', 'Humans', 'Male', 'Outcome Assessment, Health Care', 'Stress Disorders, Post-Traumatic', 'Treatment Outcome'] | 28,161,655 | [['M01.060.057'], ['F01.470.132'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['M01.060.406'], ['I01.198.240.748.300', 'I01.198.240.856.350.250.255', 'I01.880.735.900.350.250.255'], ['F04.754.137.350'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644.145.431', 'N04.761.559.590', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
[The cellular mechanism of action of gastrin on the corporal mucosa of the canine stomach. (2) Ca2+-activated, phospholipid-dependent protein kinase and phospholipid turnover--possible mediator of gastrin action]. | The existence of Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C), the effect of gastrin on phospholipid metabolism and guanylate cyclase activity were investigated to elucidate the cellular mechanism of action of gastrin on the corporal mucosa of the canine stomach. Protein kinase activity was ... | ['Animals', 'Calcium', 'Dogs', 'Gastric Mucosa', 'Gastrins', 'Guanylate Cyclase', 'In Vitro Techniques', 'Phospholipids', 'Protein Kinases'] | 6,137,423 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.649.313.750.250.216.200'], ['A03.556.875.875.440', 'A10.615.550.291'], ['D06.472.317.413', 'D06.472.699.280', 'D12.644.400.320', 'D12.644.548.280', 'D12.776.631.650.320'], ['D08.811.520.650.600', 'D12.644.360.350', 'D12.776.476.350']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modeling HIV quasispecies evolutionary dynamics. | BACKGROUND: During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively). The switch in coreceptor usage has been correlated with a faster progression of the disease to the AIDS phase. As ... | ['Antigenic Variation', 'Evolution, Molecular', 'HIV Antigens', 'HIV Infections', 'HIV-1', 'Humans', 'Likelihood Functions', 'Models, Biological', 'Mutation', 'Phenotype', 'Phylogeny', 'Receptors, CCR5', 'Receptors, CXCR4', 'Superinfection', 'T-Lymphocytes', 'Time Factors'] | 17,767,733 | [['G05.365.073', 'G12.500.249'], ['G05.045.250', 'G16.075.250'], ['D23.050.327.520'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Unidirectional P-body transport during the yeast cell cycle. | P-bodies belong to a large family of RNA granules that are associated with post-transcriptional gene regulation, conserved from yeast to mammals, and influence biological processes ranging from germ cell development to neuronal plasticity. RNA granules can also transport RNAs to specific locations. Germ granules transp... | ['Biological Transport', 'Cell Cycle', 'Cytoplasmic Granules', 'Microfluidics', 'Saccharomyces cerevisiae'] | 24,918,601 | [['G03.143'], ['G04.144'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['B01.300.107.795.785.800', 'B01.300.930.705.655']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparisons of Waist Circumference Measurements at Five Different Anatomical Sites in Chinese Children. | This study compared the waist circumference (WC) measurements of Chinese children at different sites to determine the relationship between WC measurements and body fat. WC was measured at five sites in 255 subjects aged 9-19 years: immediately below the lowest rib (WC1), at the narrowest waist (WC2), the midpoint betwe... | ['Absorptiometry, Photon', 'Adiposity', 'Adolescent', 'Age Factors', 'Analysis of Variance', 'Anthropometry', 'Body Composition', 'Body Mass Index', 'Child', 'China', 'Female', 'Humans', 'Male', 'Reproducibility of Results', 'Risk Factors', 'Waist Circumference', 'Young Adult'] | 28,261,614 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Inauguration of pediatric neurosurgery by Harvey W. Cushing: his contributions to the surgery of posterior fossa tumors in children. Historical vignette. | Development of posterior fossa surgery remains Harvey Cushing's hallmark contribution to pediatric neurosurgery. During the era before Cushing, posterior fossa lesions were considered inoperable, and only osseous decompressive surgery was offered. The evolution of Cushing's surgical expertise from subtemporal decompres... | ['Adolescent', 'Cerebellar Neoplasms', 'Cerebral Ventricle Neoplasms', 'Child', 'Child, Preschool', 'Cranial Fossa, Posterior', 'Craniotomy', 'Decompression, Surgical', 'Electrocoagulation', 'England', 'Fourth Ventricle', 'History, 20th Century', 'Humans', 'Infant'] | 14,758,958 | [['M01.060.057'], ['C04.588.614.250.195.411.211', 'C10.228.140.211.500.200', 'C10.228.140.252.200', 'C10.551.240.250.400.300'], ['C04.588.614.250.195.205', 'C10.228.140.211.280', 'C10.551.240.250.200'], ['M01.060.406'], ['M01.060.406.448'], ['A01.456.830.200', 'A02.835.232.781.750.400'], ['E04.525.190'], ['E04.188'], [... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Inhibitory effect and molecular mechanism of mesenchymal stem cells on NSCLC cells. | Non-small-cell lung cancer (NSCLC) is still the main threat of cancer-associated death. Current treatment of NSCLC has limited effectiveness, and unfortunately, the prognosis of NSCLC remains poor. Therefore, a novel strategy for cancer therapy is urgently needed. Stem cell therapy has significant potential for cancer ... | ['A549 Cells', 'Carcinoma, Non-Small-Cell Lung', 'Cell Movement', 'Cell Proliferation', 'Coculture Techniques', 'HEK293 Cells', 'Humans', 'Lung Neoplasms', 'MAP Kinase Signaling System', 'Mesenchymal Stem Cells', 'Paracrine Communication'] | 28,887,716 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.481.500.374'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.11... | ['Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The fan effect in fMRI: left hemisphere specialization in verbal working memory. | We studied the fan effect of verbal working memory using functional magnetic resonance imaging (fMRI). Participants were presented with a sentence-pair matching task that described semantic relationships (e.g. classroom-school). Working memory load and semantic processing were manipulated by increasing the number of se... | ['Adult', 'Analysis of Variance', 'Brain Mapping', 'Cerebral Cortex', 'Female', 'Functional Laterality', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Memory, Short-Term', 'Oxygen', 'Photic Stimulation', 'Semantics', 'Serial Learning', 'Verbal Learning', 'Word Association Tests... | 15,305,123 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Nerve-sparing class III radical hysterectomy: a modified technique to spare the pelvic autonomic nerves without compromising radicality. | The objectives were to describe our nerve-sparing class III radical hysterectomy technique and assess the feasibility and safety of the procedure as well as its impact on voiding function. From January to August 2005, 21 consecutive patients with FIGO stage IB-IIA cervical cancer and 1 patient with clinical stage II en... | ['Adult', 'Autonomic Nervous System', 'Female', 'Humans', 'Hysterectomy', 'Middle Aged', 'Pelvis', 'Uterine Cervical Neoplasms'] | 16,884,390 | [['M01.060.116'], ['A08.800.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['M01.060.116.630'], ['A01.923.600'], ['C04.588.945.418.948.850', 'C13.351.500.852.593.131', 'C13.351.500.852.762.850', 'C13.351.937.418.875.850']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transformation of synthetic pyrethroid insecticides by a thermophilic Bacillus sp. | Employing a mineral salts medium containing Tween 80 as the primary carbon source, a strain of Bacillus stearothermophilus was isolated which was able to hydrolyse selected second and third-generation pyrethroids to non-insecticidal products. Of a range of pyrethroid insecticides the trans-isomer of permethrin was the ... | ['Benzoates', 'Geobacillus stearothermophilus', 'Pyrethrins'] | 1,417,418 | [['D02.241.223.100', 'D02.455.426.559.389.127'], ['B03.300.390.400.158.400.400', 'B03.353.500.100.400.400', 'B03.510.100.100.400.400', 'B03.510.415.400.158.400.400', 'B03.510.460.410.158.400.400'], ['D02.455.849.575.188.750']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Willingness to pay for policies to reduce future deaths from climate change: evidence from a British survey. | OBJECTIVES: Without urgent action, climate change will put the health of future populations at risk. Policies to reduce these risks require support from today's populations; however, there are few studies assessing public support for such policies. Willingness to pay (WtP), a measure of the maximum a person is prepared... | ['Adult', 'Climate Change', 'Cross-Sectional Studies', 'Female', 'Forecasting', 'Health Policy', 'Humans', 'Male', 'Public Health', 'Surveys and Questionnaires', 'United Kingdom'] | 31,326,760 | [['M01.060.116'], ['G16.500.175.374'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.320'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['E05.318.308.980', 'N... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[Oscillations of the internal ear basilar membrane in the sonic and ultrasonic range from the data of mathematical analysis of the hydrodynamic model of the cochlea]. | Results are presented of plotting a dimeric mathematical model of human internal ear cochlea with allowance for the dependence of the basilar membrane mass on the length of its region between the registered point and the labyrinth wall of the threshold window region. Investigations carried out on such a model by means ... | ['Acoustic Stimulation', 'Basilar Membrane', 'Cochlea', 'Humans', 'Mathematics', 'Models, Theoretical', 'Ultrasonics'] | 2,346,755 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['A09.246.300.246.125', 'A10.615.179.124'], ['A09.246.300.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.548'], ['E05.599'], ['H01.671.031.849']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Using neural networks to identify patients unlikely to achieve a reduction in bodily pain after total hip replacement surgery. | OBJECTIVES: Fourteen patient-provided variables were chosen as potential predictors for improvement after total hip replacement surgery. These variables included patient demographic information, as well as preoperative physical function.METHODS: A neural network was trained to predict the relative success of total hip ... | ['Activities of Daily Living', 'Arthroplasty, Replacement, Hip', 'Female', 'Follow-Up Studies', 'Hip Joint', 'Humans', 'Linear Models', 'Male', 'Medicare', 'Middle Aged', 'Neural Networks, Computer', 'Outcome Assessment, Health Care', 'Pain', 'Pain Measurement', 'Reproducibility of Results', 'Risk Factors', 'Sensitivit... | 9,338,528 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Ps... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Nuclear localization signals of varicella zoster virus ORF4. | The varicella zoster virus (VZV) ORF4 protein, one of immediate-early genes protein, is associated with the tegument in purified virions. ORF4 protein functions at both transcriptional and post-transcriptional levels, present during different phase of whole VZV life cycle. ORF4 protein acts as a nucleocytoplasm shuttle... | ['Amino Acid Sequence', 'Base Sequence', 'DNA Primers', 'HEK293 Cells', 'Herpesvirus 3, Human', 'Humans', 'Microscopy, Fluorescence', 'Molecular Sequence Data', 'Nuclear Localization Signals', 'Open Reading Frames', 'Polymerase Chain Reaction', 'Protein Transport', 'RNA Processing, Post-Transcriptional', 'Transcription... | 24,398,930 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['A11.251.210.172.750', 'A11.436.334'], ['B04.280.382.100.900.460'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.458', 'E05.595.458']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Working towards the development of innovative ultrasound equipment for the extraction of virgin olive oil. | Malaxation has been recognized as one of the most critical points in the mechanical extraction process for virgin olive oil (VOO). It is a low and continuous kneading of olive paste at a carefully monitored temperature. Through this essential technological operation the small droplets of the oil formed during the milli... | ['Fruit', 'Olea', 'Olive Oil', 'Plant Oils', 'Sonication'] | 23,538,120 | [['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.650.940.800.575.912.250.583.640.666'], ['D10.212.302.380.580', 'D10.212.507.650', 'D10.627.700.728', 'G07.203.300.375.400.500', 'J02.500.375.400.500'], ['D10.627.700', 'D20.215.784.750'], ['E05.848']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathways. | BACKGROUND: Maternal diabetes affects the developing fetal cardiovascular system. Newborn offspring of diabetic mothers can have a transient cardiomyopathy. We hypothesized that cardiomyopathic remodeling is associated with activation of the mitogen activated protein kinase (MAPK) signaling and apoptotic pathways.METHO... | ['Animals', 'Animals, Newborn', 'Apoptosis', 'Cardiomyopathy, Dilated', 'Cardiomyopathy, Hypertrophic', 'Caspases', 'Diabetes Mellitus, Experimental', 'Enzyme Activation', 'Extracellular Signal-Regulated MAP Kinases', 'Female', 'Hypertrophy, Left Ventricular', 'Insulin', 'JNK Mitogen-Activated Protein Kinases', 'MAP Ki... | 19,646,268 | [['B01.050'], ['B01.050.050.282'], ['G04.146.954.035'], ['C14.280.195.160', 'C14.280.238.070', 'C16.320.488.750'], ['C14.280.238.100', 'C14.280.484.048.750.070.160'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['C18.452.394.750.074', 'C19.246.240', 'E05... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interactions between paraquat and ferric complexes in the microsomal generation of oxygen radicals. | Transition metals may play a central role in the toxicity associated with paraquat. Studies were carried out to evaluate the interaction of paraquat with several ferric complexes in the promotion of oxygen radical generation by rat liver microsomes. In the absence of added iron, paraquat produced some increase in low l... | ['Animals', 'Ferric Compounds', 'Free Radicals', 'Hydroxides', 'Hydroxyl Radical', 'In Vitro Techniques', 'Lipid Peroxidation', 'Luminescent Measurements', 'Male', 'Microsomes, Liver', 'NADP', 'Oxygen', 'Paraquat', 'Rats', 'Rats, Inbred Strains'] | 2,550,014 | [['B01.050'], ['D01.490.100'], ['D01.339', 'D02.389'], ['D01.045.250', 'D01.248.497.158.459'], ['D01.045.250.357', 'D01.248.497.158.459.300', 'D01.339.431.249'], ['E05.481'], ['G02.111.515', 'G03.295.531.587'], ['E05.196.712.516'], ['A11.284.835.540.541'], ['D03.633.100.759.646.138.749', 'D08.211.625', 'D13.695.667.138... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence and age distribution of human papillomavirus infection in a population of Inuit women in Nunavik, Quebec. | OBJECTIVES: Our aim was to study the prevalence and age distribution of human papillomavirus (HPV) infection among Inuit women in Nunavik, northern Quebec, a population at high risk of cervical cancer.METHODS: We recruited a cohort of Inuit women seeking routine care and living primarily in four communities of the Nuna... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'DNA, Viral', 'Female', 'Humans', 'Inuits', 'Middle Aged', 'Papanicolaou Test', 'Papillomavirus Infections', 'Prevalence', 'Prospective Studies', 'Quebec', 'Uterine Cervical Diseases', 'Vaginal Smears'] | 18,990,756 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['D13.444.308.568'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150.600.375.500', 'M01.686.508.150.675', 'M01.686.754.254.500.500'], ['M01.060.116.630'], ['E01.370.225.500.384.100.422', 'E0... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Contrast echocardiography improves the accuracy and reproducibility of left ventricular remodeling measurements: a prospective, randomly assigned, blinded study. | OBJECTIVES: We sought to assess the impact of contrast injection and harmonic imaging, on the measure by echocardiography of left ventricular (LV) remodeling.BACKGROUND: Left ventricular remodeling is a precursor of LV dysfunction, but the impact of contrast injection and harmonic imaging on the accuracy or reproducibi... | ['Aged', 'Albumins', 'Contrast Media', 'Echocardiography, Doppler', 'Female', 'Fluorocarbons', 'Humans', 'Image Enhancement', 'Male', 'Middle Aged', 'Observer Variation', 'Prospective Studies', 'Reproducibility of Results', 'Stroke Volume', 'Tomography, X-Ray Computed', 'Ventricular Function, Left', 'Ventricular Remode... | 11,527,647 | [['M01.060.116.100'], ['D12.776.034'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['D02.455.526.510.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['M01.060.116.630... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The effects of acute alcohol consumption and eccentric muscle damage on neuromuscular function. | Voluntary and electrically stimulated muscular performance was examined to identify the effects of acute alcohol consumption on neuromuscular function in the presence and absence of exercise-induced muscle damage (EIMD). After initial neuromuscular performance measures were made, 12 subjects completed a bout of eccentr... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Alcoholic Beverages', 'Analysis of Variance', 'Creatine Kinase', 'Electric Stimulation', 'Electromyography', 'Humans', 'Isometric Contraction', 'Linear Models', 'Male', 'Muscle Strength', 'Neuromuscular Junction', 'New Zealand', 'Quadriceps Muscle', 'Resistance Training', 'T... | 22,185,621 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['G07.203.100.100', 'J02.200.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D08.811.913.696.640.150'], ['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494.472'], ['E05... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Anthropology, Educ... | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis. | Amyotrophic lateral sclerosis is a neurodegenerative disease affecting the anterior horn cells of the spinal cord and cortical motor neurons. Previous findings have suggested a specific impairment of mitochondrial function in skeletal muscle of at least a limited number of patients. Applying flavoprotein/NAD(P)H autofl... | ['Adult', 'Aged', 'Amyotrophic Lateral Sclerosis', 'Blotting, Southern', 'Cell Membrane', 'DNA, Mitochondrial', 'Electron Transport', 'Female', 'Humans', 'Male', 'Microscopy, Fluorescence', 'Middle Aged', 'Mitochondria, Muscle', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Prostaglandin-Endoperoxide Synthases', 'Seq... | 10,869,047 | [['M01.060.116'], ['M01.060.116.100'], ['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['A11.284.149'], ['D13.444.308.283.225'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['B01.050.150.900.649.313.988.40... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
First evidence of diversity in eutherian chiasmatic architecture: tree shrews, like marsupials, have spatially segregated crossed and uncrossed chiasmatic pathways. | In the optic chiasm of mammals, axons either cross the midline to the opposite side of the brain or remain uncrossed. In the eutherian species studied to date, uncrossed axons in the caudal nerve are found in all regions. In the chiasm, they are dispersed through the hemichiasm, with many axons approaching the midline ... | ['Animals', 'Axons', 'Brain Mapping', 'Marsupialia', 'Nerve Fibers', 'Optic Chiasm', 'Retinal Ganglion Cells', 'Shrews', 'Visual Pathways'] | 9,453,663 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.573'], ['A08.675.542', 'A11.671.501'], ['A08.186.211.200.317.578', 'A08.800.800.120.680.600'], ['A08.675.650.850.875', 'A09.371.729.831... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preoperative pain and function profiles reflect consistent TKA patient selection among US surgeons. | BACKGROUND: As the number of primary total knee arthroplasties (TKAs) performed in the United States increases, policymakers have questioned whether the indications and timing of TKA have evolved so that surgery is offered earlier.QUESTIONS/PURPOSES: We analyzed data from a US national TKA cohort to evaluate variation ... | ['Activities of Daily Living', 'Arthralgia', 'Arthroplasty, Replacement, Knee', 'Biomechanical Phenomena', 'Databases, Factual', 'Disability Evaluation', 'Elective Surgical Procedures', 'Humans', 'Knee Joint', 'Pain Measurement', 'Patient Selection', 'Physical Examination', "Practice Patterns, Physicians'", 'Predictive... | 24,957,788 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['C05.550.091', 'C23.888.592.612.094', 'F02.830.816.444.350', 'G11.561.790.444.350'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['G01.154.090', 'G01.374.089'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E01.37... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
A bright red-emitting flavonoid for Al3+ | A bright red-emitting flavonoid derivative was synthesized, which exhibited a large Stokes shift (Äë > 150 nm) and high fluorescence quantum yields (öfl = 0.10-0.35). The probe could form a stable complex with Al3+ in 1 : 1 binding stoichiometry, generating a large bathochromic shift in both absorption and fluorescence... | ['Aluminum', 'Cell Line', 'Cell Survival', 'Flavonoids', 'Fluorescence', 'Fluorescent Dyes', 'Humans', 'Molecular Structure', 'Optical Imaging'] | 31,143,886 | [['D01.268.557.050', 'D01.552.547.050'], ['A11.251.210'], ['G04.346'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570', 'G02.466'], ['E01.370.35... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of the 'live high-train low' method on prooxidant/antioxidant balance on elite athletes. | BACKGROUND/OBJECTIVES: We previously demonstrated that acute exposure to hypoxia (3 h at 3000 m) increased oxidative stress markers. Thus, by using the 'living high-training low' (LHTL) method, we further hypothesized that intermittent hypoxia associated with endurance training alters the prooxidant/antioxidant balance... | ['Altitude', 'Antioxidants', 'Carotenoids', 'Exercise', 'Humans', 'Hypoxia', 'Lipid Metabolism', 'Lycopene', 'Male', 'Malondialdehyde', 'Oxidative Stress', 'Physical Endurance', 'Proteins', 'Reactive Oxygen Species', 'Running', 'Sports', 'Vitamin A', 'Vitamin E', 'Vitamins', 'alpha-Tocopherol', 'beta Carotene'] | 18,398,420 | [['G16.500.275.058', 'N06.230.058'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['G03.458'], ['D... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Genetic determinants of response to aspirin: appraisal of 4 candidate genes. | INTRODUCTION: Intersubject variability in platelet response to aspirin could be related to genetic factors that regulate platelet enzymes or receptors. This study evaluates the impact of the selected polymorphisms in the COX-1 gene, the CYP5A1 gene, the P2RY1 receptor gene, and the GPIIbIIIa receptor gene on platelet r... | ['Aged', 'Aspirin', 'Coronary Artery Disease', 'Cyclooxygenase 1', 'Female', 'Follow-Up Studies', 'Genotype', 'Humans', 'Male', 'Platelet Aggregation', 'Platelet Glycoprotein GPIIb-IIIa Complex', 'Polymorphism, Genetic', 'Prospective Studies', 'Receptors, Purinergic P2Y1', 'Thromboxane-A Synthase'] | 21,429,568 | [['M01.060.116.100'], ['D02.455.426.559.389.657.410.595.176'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['D08.811.600.720.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.18... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Iron infusion and deposition in the kidney. | BACKGROUND: Parenteral iron therapy is the mainstay of treating iron deficiency anemia in chronic kidney disease (CKD) patients.METHODS: Retrospective case study of iron staining of renal tissues in 2 CKD patients who had received intravenous iron prior to the renal biopsy.RESULTS: Following the infusion of ferumoxytol... | ['Aged', 'Humans', 'Infusions, Intravenous', 'Iron', 'Kidney', 'Male', 'Middle Aged', 'Oxidative Stress'] | 23,182,397 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['A05.810.453'], ['M01.060.116.630'], ['G03.673', 'G07.775.750']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of genistein and herbimycin, tyrosine kinase inhibitors, on catecholamine release in bovine adrenal chromaffin cells. | 1 The effects of genistein and herbimycin, tyrosine kinase inhibitors, on catecholamine (CA) release were examined in bovine adrenal chromaffin cells. 2 In intact cells, genistein (10-100 microm) and herbimycin (3-30 microm) inhibited CA release induced by acetylcholine (ACh; 100 microm) or the nicotinic receptor stimu... | ['Animals', 'Benzoquinones', 'Catecholamines', 'Cattle', 'Cells, Cultured', 'Chromaffin Cells', 'Genistein', 'Lactams, Macrocyclic', 'Protein Kinase Inhibitors', 'Rifabutin'] | 18,076,479 | [['B01.050'], ['D02.806.250'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['A06.224.161', 'A11.299'], ['D03.383.663.283.266.450.400.375', 'D03.633.100.150.266.450.400.375'], ['D02.065.589.327', 'D04.345.295'], ['D27.505.519.389.755'], ['D03.633.400.811.650'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuro-endocrine type of gastric carcinoma. Immunohistochemical and electron microscopic studies of 100 cases. | 1,351 specimens resected surgically from 100 patients with gastric carcinoma were studied with PAP immunoperoxidase and ultrastructural method. The tumor cells were found positive for gastrin, serotonin, somatostatin and argyrophil particles in 19 patients. Among them the gastrin-secreting tumor cells consisted of 50% ... | ['Adenocarcinoma, Mucinous', 'Adult', 'Aged', 'Female', 'Gastrins', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Serotonin', 'Somatostatin', 'Stomach Neoplasms'] | 1,976,491 | [['C04.557.470.200.025.075', 'C04.557.470.590.075'], ['M01.060.116'], ['M01.060.116.100'], ['D06.472.317.413', 'D06.472.699.280', 'D12.644.400.320', 'D12.644.548.280', 'D12.776.631.650.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', '... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical study of the effects of deep brain stimulation on urinary dysfunctions in patients with Parkinson's disease. | Purpose: To evaluate the effect of deep brain stimulation (DBS) on urinary dysfunctions in Parkinson's patients. Patients and methods: A total of 416 patients, diagnosed with Parkinson's disease (PD) based on the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria, were enrolled in the study, including 307 ma... | ['Age Factors', 'Aged', 'Basic Helix-Loop-Helix Transcription Factors', 'Deep Brain Stimulation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Parkinson Disease', 'Quality of Life', 'Severity of Illness Index', 'Sex Factors', 'Urinary Bladder, Overactive', 'Urination', 'Urodynamics'] | 31,417,246 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D12.776.260.103', 'D12.776.930.125'], ['E02.331.300', 'E04.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.574.928.750'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.4... | ['Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
In vivo proton magnetic resonance spectroscopy in a case of Reye's syndrome. | A case of a 14-year-old boy with Reye's syndrome (RS) and complete neurologic recovery is presented. 1H magnetic resonance spectroscopy was performed on days 1 (admission to ICU), 8 and 62: During the acute phase of RS substantial cerebral metabolic imbalances were observed and their normalization monitored. The spectr... | ['Adolescent', 'Brain', 'Choline Deficiency', 'Glasgow Coma Scale', 'Glutamine', 'Humans', 'Magnetic Resonance Spectroscopy', 'Male', 'Reye Syndrome'] | 7,790,619 | [['M01.060.057'], ['A08.186.211'], ['C18.654.521.500.133.699.160'], ['E05.318.308.940.968.875.250', 'E05.944.500', 'N04.452.859.564.800.250', 'N05.715.360.300.715.500.800.325'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['C06.552.241... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long-term refractive status of preterm infants from singleton and multiple pregnancies | OBJECTIVE: To study the effect of plurality on refractive status in former preterm infants at age 8-12 years.METHODS: Refraction was compared in singletons and multiples, in very low birth weight infants (VLBW, <1500 g) at age 6 months and 8-12 years. Preterm infants were compared with a group of term infants.RESULTS: ... | ['Case-Control Studies', 'Child', 'Female', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Israel', 'Pregnancy', 'Pregnancy, Multiple', 'Refractive Errors'] | 27,718,778 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['Z01.252.245.500.375'], ['G08.686.784.769'], ['G08.686.784.769.545'], ['C11.744']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Overview of dermatophytes in Mali]. | 517 isolations of dermatophytes collected in Mali are reported. The various species are described and the main findings are: --Trichophyton species are more common (85.5% isolated from scalp lesions and 77.5% from skin scrapings) than Microsporum species. --Trichophyton verrucosum and Microsporum canis have been found ... | ['Adult', 'Arthrodermataceae', 'Child', 'Humans', 'Mali', 'Microsporum', 'Scalp', 'Skin', 'Trichophyton'] | 498,384 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. | The duration of a woman's reproductive period is determined by the size and persistence of a dormant oocyte pool. Specific oocyte genes are essential for follicle maintenance and female fertility. The mechanisms that regulate the expression of these genes are poorly understood. We found that a cullin-ring finger ligase... | ['Animals', 'Carrier Proteins', 'Cell Survival', 'Cellular Reprogramming', 'Cullin Proteins', 'DNA-Binding Proteins', 'Dioxygenases', 'Female', 'Fertility', 'Gene Silencing', 'Gonadal Dysgenesis', 'HeLa Cells', 'Humans', 'Mice', 'Mice, Knockout', 'Mixed Function Oxygenases', 'Oocytes', 'Ovary', 'Protein-Serine-Threonin... | 24,357,321 | [['B01.050'], ['D12.776.157'], ['G04.346'], ['G04.152.262', 'G05.135'], ['D08.811.464.938.750.750.500', 'D12.776.167.175'], ['D12.776.260'], ['D08.811.682.690.416'], ['G08.686.210'], ['G05.308.203.374'], ['C12.706.316.309', 'C13.351.875.253.309', 'C16.131.939.316.309', 'C19.391.119.309'], ['A11.251.210.190.400', 'A11.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. | Spinal reflexes are mediated by synaptic connections between sensory afferents and motor neurons. The organization of these circuits shows several levels of specificity. Only certain classes of proprioceptive sensory neurons make direct, monosynaptic connections with motor neurons. Those that do are bound by rules of m... | ['Animals', 'Cell Adhesion Molecules, Neuronal', 'Cytoskeletal Proteins', 'Glycoproteins', 'Intracellular Signaling Peptides and Proteins', 'Membrane Glycoproteins', 'Membrane Proteins', 'Mice', 'Models, Neurological', 'Motor Neurons', 'Muscle, Skeletal', 'Nerve Tissue Proteins', 'Neural Pathways', 'Proprioception', 'R... | 19,421,194 | [['B01.050'], ['D12.776.395.550.200.250', 'D12.776.543.550.200.250', 'D23.050.301.350.250'], ['D12.776.220'], ['D09.400.430', 'D12.776.395'], ['D12.644.360', 'D12.776.476'], ['D12.776.395.550', 'D12.776.543.550'], ['D12.776.543'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.395.642'], ['A08.675.655.500', 'A1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro platelet adhesion to dialysis membranes. | This work describes an in vitro system developed to quantitate platelet deposition on different dialysis membranes. The system is based on the use of small dialysis filters and reproduces the haemodynamic pattern of blood flowing through hollow fibres during in vivo dialysis. We have determined the in vitro platelet ad... | ['Albumins', 'Blood Platelets', 'Cellulose', 'Humans', 'Indium Radioisotopes', 'Membranes, Artificial', 'Methylmethacrylates', 'Platelet Adhesiveness', 'Renal Dialysis'] | 1,866,066 | [['D12.776.034'], ['A11.118.188', 'A15.145.229.188'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.496.749.460'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['D02.241.081.069.800.550', 'D05.750.716.822.111.650.60... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Spinal sonography in newborns and infants - part II: spinal dysraphism and tethered cord. | UNLABELLED: Patients with cutaneous markers in the lumbo-sacral region as well as infants with bladder and bowel dysfunction, orthopedic anomalies and progressive neurological dysfunction are at risk for spinal dysraphism and tethered cord. Three types of spinal dysraphism can be distinguished: Type I - open spinal dys... | ['Humans', 'Infant', 'Infant, Newborn', 'Lipoma', 'Neural Tube Defects', 'Spinal Cord', 'Spinal Dysraphism', 'Ultrasonography'] | 17,610,176 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C04.557.450.550.400'], ['C10.500.680', 'C16.131.666.680'], ['A08.186.854'], ['C10.500.680.800', 'C16.131.666.680.800'], ['E01.370.350.850']] | ['Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The inclusion of functional foods enriched in fibre, calcium, iodine, fat-soluble vitamins and n-3 fatty acids in a conventional diet improves the nutrient profile according to the Spanish reference intake. | OBJECTIVE: The growing interest in maintaining good health status through optimal nutrition has boosted the launch of a number of functional foods on the market. The objective of the present study was to theoretically evaluate the nutritional relevance of incorporating selected enriched foods in the diet.DESIGN: A 28 d... | ['Calcium, Dietary', 'Dairy Products', 'Diet', 'Dietary Fiber', 'Energy Intake', 'Fatty Acids, Omega-3', 'Functional Food', 'Humans', 'Iodine', 'Margarine', 'Nutrition Policy', 'Nutritional Status', 'Nutritive Value', 'Spain', 'Vitamins'] | 21,092,358 | [['D01.146.395'], ['G07.203.300.350', 'J02.500.350'], ['G07.203.650.240'], ['D09.301.416', 'G07.203.300.400', 'J02.500.400'], ['G07.203.650.240.340'], ['D10.212.302.380.410', 'D10.251.355.337', 'D10.627.430.450'], ['G07.203.300.572', 'J02.500.572'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400'], ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
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