Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. | OBJECTIVES: Systematic parsing of executive function processes is critical for the development of more specific models of neurobiological processes mediating disturbed cognition in youth with bipolar disorder (BPD).METHODS: A sample of 33 children and adolescents with bipolar I disorder (BPD I) (mean age 12.1 +/- 3.0 y... | ['Adolescent', 'Age Factors', 'Attention', 'Bipolar Disorder', 'Case-Control Studies', 'Child', 'Cognition Disorders', 'Female', 'Humans', 'Male', 'Memory, Short-Term', 'Multivariate Analysis', 'Neuropsychological Tests', 'Prefrontal Cortex', 'Problem Solving', 'Sex Factors', 'Verbal Behavior'] | 17,543,033 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['F02.830.104.214'], ['F03.084.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['F03.615.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.407'], ['E05.318.740.150.500', 'N05.715.360.... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Porencephaly and transverse limb defects following severe maternal trauma in early pregnancy. | A 13 year old boy with mental retardation, hemiatrophy and left hemiplegia, right hemifacial microsomia and transverse digital amputations is reported. He is moderately mentally retarded, experiences grand mal seizures and has evidence of a porencephalic cyst in the right frontotemporal region on CT scan. At 52 days po... | ['Abnormalities, Multiple', 'Accidents, Traffic', 'Adolescent', 'Brain', 'Facial Asymmetry', 'Female', 'Fetal Hypoxia', 'Gestational Age', 'Hemiplegia', 'Humans', 'Intellectual Disability', 'Limb Deformities, Congenital', 'Male', 'Pregnancy', 'Pregnancy Complications', 'Thromboembolism', 'Wounds and Injuries'] | 7,735,509 | [['C16.131.077'], ['N06.850.135.392'], ['M01.060.057'], ['A08.186.211'], ['C23.300.505'], ['C13.703.277.390', 'C16.300.420', 'C23.888.852.079.594'], ['G07.345.500.325.235.968', 'G08.686.320'], ['C10.597.622.295', 'C23.888.592.636.312'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.6... | ['Diseases [C]', 'Health Care [N]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function. | Increasing evidence has confirmed that hinokitiol (beta-thujaplicin), a tropolone-related compound, exhibits anticancer activity in a variety of cancers through inhibition of cell proliferation. The present study indicates that hinokitiol selectively inhibits cell growth and DNA synthesis in FEM human melanoma cells. H... | ['Cell Line, Tumor', 'Cell Proliferation', 'Cells, Cultured', 'Cyclin-Dependent Kinase 2', 'Cyclin-Dependent Kinase Inhibitor p27', 'Dose-Response Relationship, Drug', 'Flow Cytometry', 'G1 Phase', 'Humans', 'Immunoblotting', 'Melanoma', 'Monoterpenes', 'Phosphorylation', 'Protein Binding', 'RNA Interference', 'Retinob... | 19,631,451 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D08.811.913.696.620.682.700.646.500.750', 'D12.644.360.250.323', 'D12.776.167.200.323', 'D12.776.476.250.323'], ['D12.644.360.225.600', 'D12.776.167.187.600', 'D12.776.476.225.600', 'D12.776.624.776.355.600'], ['G07.690.773.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A benchmark concentration analysis for manganese in drinking water and IQ deficits in children. | BACKGROUND: Manganese is an essential nutrient, but in excess, can be a potent neurotoxicant. We previously reported findings from two cross-sectional studies on children, showing that higher concentrations of manganese in drinking water were associated with deficits in IQ scores. Despite the common occurrence of this ... | ['Adolescent', 'Benchmarking', 'Child', 'Child, Preschool', 'Cognition', 'Drinking Water', 'Environmental Exposure', 'Female', 'Humans', 'Intelligence Tests', 'Male', 'Manganese'] | 31,200,154 | [['M01.060.057'], ['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['M01.060.406'], ['M01.060.406.448'], ['F02.463.188'], ['D01.045.250.875.300', 'D01.248.497.158.459.650.300', 'D01.650.550.925.199', 'G07.203.100.418', 'J02.200.418'], ['N06.850.460.350'], ['B01.050.150.90... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Role of the N-terminal catalytic domain of angiotensin-converting enzyme investigated by targeted inactivation in mice. | Angiotensin-converting enzyme (ACE) produces the vasoconstrictor angiotensin II. The ACE protein is composed of two homologous domains, each binding zinc and each independently catalytic. To assess the physiologic significance of the two ACE catalytic domains, we used gene targeting in mice to introduce two point mutat... | ['Anemia', 'Animals', 'Catalytic Domain', 'Mice', 'Oligopeptides', 'Peptidyl-Dipeptidase A', 'Point Mutation', 'Renin-Angiotensin System', 'Structure-Activity Relationship', 'Substrate Specificity'] | 14,757,757 | [['C15.378.071'], ['B01.050'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.644.456'], ['D08.811.277.656.350.350.687'], ['G05.365.590.675'], ['G03.820', 'G09.330.380.813'], ['G02.111.830', 'G07.690.773.997'], ['G02.111.835']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A randomised placebo-controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea. | BACKGROUND: Most traditional Chinese herbal formulas consist of at least four herbs. Four-Agents-Decoction (Si Wu Tang) is a documented eight hundred year old formula containing four herbs and has been widely used to relieve menstrual discomfort in Taiwan. However, no specific effect had been systematically evaluated. ... | ['Adult', 'Analgesics', 'Drugs, Chinese Herbal', 'Dysmenorrhea', 'Female', 'Humans', 'Medicine, Chinese Traditional', 'Pain Measurement', 'Pilot Projects', 'Placebos', 'Pregnancy', 'Surveys and Questionnaires', 'Taiwan', 'Young Adult'] | 17,710,126 | [['M01.060.116'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D20.215.784.500.350', 'D26.335'], ['C23.550.568.750', 'C23.888.592.612.944.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.488.585.520', 'I01.076.201.450.654.558.520'], ['E01.370.600.550.324'], ['E05.318.372.750', 'E05.337.737', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Fe- and Ln-DOTAm-F12 Are Effective Paramagnetic Fluorine Contrast Agents for MRI in Water and Blood. | A series of fluorinated macrocyclic complexes, M-DOTAm-F12, where M is LaIII, EuIII, GdIII, TbIII, DyIII, HoIII, ErIII, TmIII, YbIII, and FeII, was synthesized, and their potential as fluorine magnetic resonance imaging (MRI) contrast agents was evaluated. The high water solubility of these complexes and the presence o... | ['Contrast Media', 'Coordination Complexes', 'Fluorine', 'Humans', 'Iron', 'Lanthanoid Series Elements', 'Magnetic Resonance Imaging', 'Molecular Structure', 'Solubility', 'Water'] | 28,094,930 | [['D27.505.259.500', 'D27.720.259'], ['D01.234', 'D02.257'], ['D01.268.380.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.268.558.362', 'D01.552.550.399'], ['E01.370.350.825.500'], ['G02.111.570', 'G02.466'], ['G02.805'], ['D01.045.250.875', 'D01... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Base-specific mutational intolerance near splice sites clarifies the role of nonessential splice nucleotides. | Variation in RNA splicing (i.e., alternative splicing) plays an important role in many diseases. Variants near 5' and 3' splice sites often affect splicing, but the effects of these variants on splicing and disease have not been fully characterized beyond the two "essential" splice nucleotides flanking each exon. Here ... | ['Alleles', 'Alternative Splicing', 'Exons', 'Humans', 'Mutation', 'Nucleotides', 'RNA Splice Sites', 'RNA Splicing'] | 29,858,273 | [['G05.360.340.024.340.030'], ['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G05.360.340.024.340.137.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['D09.408.620', 'D13.695'], ['D13.444.735.544.550', 'G02.111.570.080.689.687.490', 'G05.360.080.689.687.490', 'G05.360.340.0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid. | We report the crystal structure of the glycosylated ligand-binding (S1S2) domain of the kainate receptor subunit GluR6, in complex with the agonist domoate. The structure shows the expected overall homology with AMPA and NMDA receptor subunit structures but reveals an unexpected binding mode for the side chain of domoa... | ['Amino Acid Sequence', 'Animals', 'Binding Sites', 'Crystallography, X-Ray', 'Kainic Acid', 'Models, Molecular', 'Molecular Sequence Data', 'Neurotoxins', 'Protein Structure, Secondary', 'Protein Subunits', 'Rats', 'Receptors, AMPA', 'Receptors, Kainic Acid', 'Sequence Alignment', 'Sequence Homology, Amino Acid'] | 15,677,325 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['D03.383.773.400'], ['E05.599.595'], ['L01.453.245.667'], ['D27.888.569.504'], ['G02.111.570.820.709.600'], ['D12.776.813'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.157.530.400.400.500.100', 'D12.776.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Non-compliance in pyridoxine-dependent seizures and a way out. | Pyridoxine dependency is a rare autosomal-recessive disorder causing intractable seizures in neonates and infants. Life-long therapy with pyridoxine is required for prevention of seizure recurrence and for an optimum intellectual outcome. With the availability of newer biochemical confirmatory tests, the conventional p... | ['Humans', 'India', 'Infant', 'Male', 'Patient Compliance', 'Pyridoxine', 'Seizures', 'Treatment Outcome'] | 17,635,690 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['M01.060.703'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.600'], ['D03.383.725.676.925.875'], ['C10.597.742', 'C23.888.592.742'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
SLICC classification criteria for juvenile systemic lupus erythematosus: a cross sectional study. | OBJECTIVES: to verify the sensitivity and specificity of the criteria for systemic lupus erythematosus, proposed by the Systemic Lupus International Collaborating Clinics (SLICC) and compare it to the ACR lupus criteria, in a pediatric population.PATIENTS AND METHODS: this is an observational cohort study, with a descr... | ['Child', 'Cohort Studies', 'Cross-Sectional Studies', 'Female', 'Humans', 'Lupus Erythematosus, Systemic', 'Male', 'Sensitivity and Specificity'] | 30,641,536 | [['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.300.480', 'C20.111.590'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Urate-lowering therapy may mitigate the risks of hospitalized stroke and mortality in patients with gout. | OBJECTIVES: Although studies have demonstrated the association of hyperuricemia with cardiovascular (CV) diseases, few have explored the effect of urate-lowering therapy (ULT) on the incidence of CV diseases. Therefore, we compared the risks of hospitalized coronary artery disease (CAD), stroke, heart failure (HF), and... | ['Adult', 'Aged', 'Allopurinol', 'Female', 'Gout', 'Gout Suppressants', 'Hospital Mortality', 'Hospitalization', 'Humans', 'Hyperuricemia', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Retrospective Studies', 'Risk Assessment', 'Stroke', 'Taiwan', 'Treatment Outcome', 'Uric Acid', 'Young Adult'] | 32,574,194 | [['M01.060.116'], ['M01.060.116.100'], ['D03.633.100.759.160'], ['C05.550.114.423', 'C05.550.354.500', 'C05.799.414', 'C16.320.565.798.368', 'C18.452.648.798.368'], ['D27.505.954.329.337'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['E02.760.400', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster. | The crystal structure of the dimerization domain of the V(D)J recombination-activating protein, RAG1, was solved using zinc anomalous scattering. The structure reveals an unusual combination of multi-class zinc-binding motifs, including a zinc RING finger and a C2H2 zinc finger, that together from a single structural d... | ['Binding Sites', 'Crystallization', 'Crystallography, X-Ray', 'DNA-Binding Proteins', 'Dimerization', 'Homeodomain Proteins', 'Hydrogen Bonding', 'Models, Molecular', 'Protein Conformation', 'Zinc', 'Zinc Fingers'] | 9,228,952 | [['G02.111.570.120'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D12.776.260'], ['G02.206', 'G03.230'], ['D12.776.260.400'], ['G02.282'], ['E05.599.595'], ['G02.111.570.820.709'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940'], ['G02.111.570.820.709.275.500.985']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Atypical subacute sclerosing panencephalitis with short onset latency. | An 11-month-old boy presented with focal seizures, myoclonic jerks and altered sensorium of one month duration, with a history of measles at eight months of age. A diagnosis of Subacute sclerosing panencephalitis (SSPE) was made on the basis of typical EEG changes and presence of anti-measles antibody in cerebrospinal ... | ['Electroencephalography', 'Humans', 'Infant', 'Male', 'Subacute Sclerosing Panencephalitis'] | 23,474,932 | [['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.207.245.340.600', 'C01.207.399.750.600', 'C01.925.182.525.600', 'C01.925.782.580.600.500.500.800', 'C01.925.839.862', 'C10.228.140.430.520.750.600', 'C10.228.228.245.340.600', 'C10.228.228.399.750.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sexual dimorphism from birth to age 60 in relation to the type of body shape. | Sexual dimorphism depends on age. It can be analysed within a population by a comparison of sex-specific body measurements based on cross-sectional samples. We analysed four length measurements, three circumferences, and one skinfold diameter of a representative cross-sectional sample of healthy German subjects aged 0 ... | ['Adult', 'Age Distribution', 'Anthropometry', 'Body Constitution', 'Body Size', 'Child', 'Child, Preschool', 'Female', 'Germany', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Sex Characteristics', 'Somatotypes', 'Statistics as Topic'] | 17,444,192 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E01.370.600.115', 'G07.100'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.542.315'], ['B01.050.150.900.6... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
A rapid one-step method to purify baculovirus-expressed human estrogen receptor to be used in the analysis of the oxytocin promoter. | We have produced a truncated form of the human estrogen receptor (hER) as a fusion protein with glutathione S-transferase (GST) in Spodoptera frugiperda (Sf) cells using the baculovirus expression vector (BEV) system. The protein is correctly produced and can be purified from crude whole-cell extracts by a single-step,... | ['Baculoviridae', 'Base Sequence', 'DNA', 'Genetic Vectors', 'Glutathione Transferase', 'Humans', 'Molecular Sequence Data', 'Receptors, Estrogen', 'Recombinant Fusion Proteins'] | 8,076,833 | [['B04.280.065', 'B04.525.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['G05.360.337'], ['D08.811.913.225.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['D12.776.826.750.350', 'D12.776.930.778.350'], ['D12.776.828.300']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Biochemical activity of lactic acid bacterial lyophilized concentrates obtained by continous cultivation]. | Microbiological and biochemical parameters of lactic acid bacterial lyophilized concentrates obtained by continous cultivation were investigated during their storage at 3 to 5 degrees C. Under these conditions lyophilized bacterial concentrates retained high activity for three months and after six months their cell sur... | ['Bacteria', 'Freeze Drying', 'Freezing', 'Kinetics', 'Lactates', 'Time Factors'] | 674,117 | [['B03'], ['E01.370.225.500.620.760.160.260', 'E01.370.225.750.600.760.160.260', 'E02.792.156.260', 'E05.200.500.620.760.160.260', 'E05.200.750.600.760.160.260', 'E05.760.156.260'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['G01.374.661', 'G02.111.490'], ['D02.241.511.459'], ['G01.910.857']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin. | Dioxins cause a variety of toxic effects through transformation of a cytosolic aryl hydrocarbon receptor (AhR). We have previously demonstrated that certain natural flavones and flavonols at the dietary levels suppress AhR transformation. In this study, we investigated whether 5 anthocyanidins, 15 anthocyanins, and pro... | ['Animals', 'Anthocyanins', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Hydroxybenzoates', 'Liver Neoplasms', 'Mice', 'Plant Extracts', 'Polychlorinated Dibenzodioxins', 'Receptors, Aryl Hydrocarbon'] | 15,630,228 | [['B01.050'], ['D03.383.663.283.266.450.087', 'D03.633.100.150.266.450.087', 'D09.408.084', 'D23.767.124'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['D02.241.223.100.300', 'D02.241.511.390', 'D02.455.426.559.389.127.281', 'D02.455... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. | Endothelial cells play significant roles in conditioning tissues after injury by the production and secretion of angiocrine factors. At least two distinct subsets of monocytes, CD45(+)CD11b(+)Gr1(+)Ly6C(+) inflammatory and CD45(+)CD11b(+)Gr1(-)Ly6C(-) anti-inflammatory monocytes, respond differentially to these angiocr... | ['Analysis of Variance', 'Animals', 'Blotting, Western', 'Cells, Cultured', 'Chemotaxis', 'Cytokines', 'DNA Primers', 'Drug Carriers', 'Fingolimod Hydrochloride', 'Flow Cytometry', 'Humans', 'Immunohistochemistry', 'Lactic Acid', 'Mice', 'Mice, Inbred C57BL', 'Microscopy, Confocal', 'Microvessels', 'Monocytes', 'Neovas... | 23,918,395 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'], ['D12.64... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Curcumin abolishes apoptosis resistance of calcitriol-differentiated HL-60 cells. | Exposure of HL-60 cells to 1,25-dihydroxyvitamin D(3) (calcitriol) induces their differentiation into monocytes. This terminal differentiation is associated with acquired resistance to many proapoptotic stimuli. Here we show that differentiated HL-60 cells undergo apoptosis upon curcumin treatment although they retain ... | ['Apoptosis', 'Calcitriol', 'Cell Differentiation', 'Curcumin', 'DNA Damage', 'HL-60 Cells', 'Humans'] | 16,876,793 | [['G04.146.954.035'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570.938.146.478.387.300'], ['G04.152'], ['D02.455.326.146.485.222.222', 'D02.455.426.559.389.657.166.200', 'D02.455.426.559.694.222'], ['G05.200'], ['A11.251.210.190.465', 'A1... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The economic impacts of using adalimumab (Humira® | AIM: The onset and progression of ankylosing spondylitis (AS) usually occurs during the life stage when individuals are more likely to be working and receiving an income, but little is known about the effects of interventions that reduce pain and improve the economic circumstances of patients out of the labour force du... | ['Absenteeism', 'Adalimumab', 'Adult', 'Anti-Inflammatory Agents', 'Australia', 'Back Pain', 'Computer Simulation', 'Cost Savings', 'Cost-Benefit Analysis', 'Drug Costs', 'Efficiency', 'Female', 'Humans', 'Income', 'Male', 'Middle Aged', 'Models, Economic', 'Pain Management', 'Pain Measurement', 'Sick Leave', 'Spondyli... | 29,611,342 | [['F02.784.692.107'], ['D12.776.124.486.485.114.224.060.250', 'D12.776.124.790.651.114.224.060.250', 'D12.776.377.715.548.114.224.200.250'], ['M01.060.116'], ['D27.505.954.158'], ['Z01.639.100', 'Z01.678.100.373'], ['C23.888.592.612.107'], ['L01.224.160'], ['N03.219.151.160.200'], ['N03.219.151.125'], ['N03.219.151.400... | ['Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Phytotoxic property of the invasive plant Tithonia diversifolia and a phytotoxic substance. | Tithonia diversifolia (Hermsl.) A. Gray is a perennial invasive plant and spreads quickly in the invasive areas. The extracts of T. diversifolia were found to be toxic to several crop plant species such as rice, maize, sorghum, lettuce and cowpea, and several putative allelopathic substances were identified. However, t... | ['Asteraceae', 'Crops, Agricultural', 'Dose-Response Relationship, Drug', 'Introduced Species', 'Plant Extracts', 'Sesquiterpenes'] | 28,605,983 | [['B01.650.940.800.575.912.250.100'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.050.580', 'G16.500.275.157.049.400', 'N06.230.124.049.400'], ['D20.215.784.500', 'D26.667'], ['D02.455.849.765']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Individual patient data meta-analysis of diagnostic and prognostic studies in obstetrics, gynaecology and reproductive medicine. | BACKGROUND: In clinical practice a diagnosis is based on a combination of clinical history, physical examination and additional diagnostic tests. At present, studies on diagnostic research often report the accuracy of tests without taking into account the information already known from history and examination. Due to t... | ['Algorithms', 'Diagnostic Techniques, Obstetrical and Gynecological', 'Endometrial Neoplasms', 'Fallopian Tube Diseases', 'Female', 'Gynecology', 'Humans', 'Ovary', 'Premature Birth', 'Prognosis', 'ROC Curve', 'Reproductive Medicine', 'Sensitivity and Specificity'] | 19,327,146 | [['G17.035', 'L01.224.050'], ['E01.370.378'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['C13.351.500.056.390'], ['H02.403.763.750', 'H02.403.810.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['C13.703.420.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Kribbella antibiotica sp. nov., a novel nocardioform actinomycete strain isolated from soil in Yunnan, China. | A novel nocardioform actinomycete strain YIM 31530T was isolated from a soil in Yunnan, China. Based on the results of phenotypic characteristics, phylogenetic studies and DNA-DNA hybridization results, strain YIM 31530T should be assigned to a new species of the genus Kribbella, for which the name Kribbella antibiotic... | ['Amino Acids', 'Base Composition', 'Base Sequence', 'Carbohydrates', 'China', 'DNA, Bacterial', 'Microscopy, Electron, Scanning', 'Molecular Sequence Data', 'Nocardia', 'Nucleic Acid Hybridization', 'Phylogeny', 'Polymerase Chain Reaction', 'RNA, Ribosomal, 16S', 'Soil Microbiology'] | 15,046,304 | [['D12.125'], ['G02.111.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D09'], ['Z01.252.474.164'], ['D13.444.308.212'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['L01.453.245.667'], ['B03.510.024.981.550'], ['E05.393.661', 'G02.111.611'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Dose-dependant hypothyroidism in mice induced by commercial trimethoprim-sulfamethoxazole rodent feed. | Trimethoprim-sulfamethoxazole (TMP-SMX) medication in the feed or water is commonly administered to immunocompro mised mice to prevent the occurrence of Pneumocystis murina (formerly P. carinii) pneumonia. Therapeutic doses of SMX can cause decreased total and free thyroxine (T4) levels in dogs and thyroid hypertrophy ... | ['Animal Feed', 'Animals', 'Body Weight', 'Chromatography, High Pressure Liquid', 'Dose-Response Relationship, Drug', 'Female', 'Fertility', 'Hypothyroidism', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Rodent Diseases', 'Thyroid Gland', 'Thyrotropin', 'Thyroxine', 'Trimethoprim, Sulfamethoxazole Drug Combination'] | 17,069,024 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E05.196.181.400.300'], ['G07.690.773.875', 'G07.690.936.500'], ['G08.686.210'], ['C19.874.482'], ['B01.050.150.900.649.313.992.635.505.500'], [... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Ileal pouch-anal anastomosis for ulcerative colitis: the University of Puerto Rico experience. | OBJECTIVE: To review the experience with ileal pouch-anal anastomosis surgery for ulcerative colitis at the University Hospital.BACKGROUND: As many as 40% of patients with ulcerative colitis (UC) and 75% with Crohn's disease (CD) require some surgery for their disease. The number of patients referred to our clinics for... | ['Adolescent', 'Adult', 'Aged', 'Colitis, Ulcerative', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Satisfaction', 'Postoperative Complications', 'Pouchitis', 'Proctocolectomy, Restorative', 'Puerto Rico', 'Quality of Life'] | 11,776,722 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.71... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Comparison of the multichannel intraluminal impedance pH and conventional pH for measuring esophageal acid exposure: a propensity score-matched analysis. | BACKGROUND: The modalities for evaluating acid reflux in medical care for gastroesophageal reflux disease (GERD) include conventional pH (C-pH), wireless pH (Bravo®) and multichannel intraluminal impedance pH (MII-pH), which have been reported to vary with respect to the duration of acid reflux. In this study, we exami... | ['Adult', 'Aged', 'Electric Impedance', 'Endoscopy, Gastrointestinal', 'Esophageal pH Monitoring', 'Female', 'Gastroesophageal Reflux', 'Hernia, Hiatal', 'Humans', 'Male', 'Middle Aged', 'Propensity Score', 'Retrospective Studies'] | 28,523,360 | [['M01.060.116'], ['M01.060.116.100'], ['G01.358.500.249.277.350'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['E01.370.372.255', 'E01.370.520.215'], ['C06.405.117.119.500.484'], ['C23.300.707.960.500.467'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mucinous cystadenocarcinoma of the retroperitoneum. | A case of a primary retroperitoneal mucinous cystadenocarcinoma of ovarian type found at laparotomy in the presence of two normal ovaries is described. Careful examination of the tumor showed no evidence of ovarian tissue in the wall. The appearance of this tumor could be traced from areas of benign mucinous cystadenom... | ['Cystadenoma', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Metastasis', 'Retroperitoneal Neoplasms'] | 854,250 | [['C04.557.470.035.320', 'C04.557.470.590.485'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.650', 'C23.550.727.650'], ['C04.588.033.731']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparative histopathology of Longicollum (Acanthocephala: Pomphorhynchidae) infection in the alimentary tract and spleen of Acanthopagrus australis (Pisces: Sparidae). | The pomphorhynchid acanthocephalan Longicollum alemniscus infected the rectum of 16 and the intestine of five of 628 Acanthopagrus australis from Moreton Bay, Queensland. The neck and proboscis penetrated the entire gut wall and were surrounded by a layer of compact, rounded fibroblasts inside a layer of elongated fibr... | ['Acanthocephala', 'Animals', 'Fish Diseases', 'Helminthiasis', 'Helminthiasis, Animal', 'Intestines', 'Perciformes', 'Spleen'] | 8,359,988 | [['B01.050.500.500.132'], ['B01.050'], ['C22.362'], ['C01.610.335'], ['C01.610.335.349', 'C01.610.701.377', 'C22.674.377'], ['A03.556.124'], ['B01.050.150.900.493.602'], ['A10.549.700', 'A15.382.520.604.700']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Concurrent Case Review and Retrospective Review Using the Matrix Method Are Complementary Methods for Tracking and Improving Timeliness of Care in a Level I Trauma Center. | Ensuring timely care for patients with moderate-to-severe traumatic injury has been shown to significantly reduce the rate of injury-related mortality. Using concurrent case review and the matrix method described in the 2014 version of Resources for Optimal Care of the Injured Patient, we sought to reduce direct admiss... | ['Adult', 'Aged', 'Female', 'Health Services Accessibility', 'Humans', 'Male', 'Middle Aged', 'Ohio', 'Patient Admission', 'Quality Improvement', 'Retrospective Studies', 'Time Factors', 'Trauma Centers', 'Triage', 'Wounds and Injuries'] | 27,097,624 | [['M01.060.116'], ['M01.060.116.100'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', 'Z01.107.567.875.510.540'], ['E02.760.400.600', 'N02.421.585.400.600'], ['J01.293.754', 'N04.761.744'], ['E05.318.372.50... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Integrating evidence-based decision making into allied health curricula. | An evidence-based approach may decrease variations in practice and time delays in adopting new procedures. This report describes the process for incorporating evidence-based decision making (EBDM) into curricula using active teaching techniques. The process centers on a national four-day Faculty Development Institute (... | ['Allied Health Occupations', 'Curriculum', 'Education, Professional', 'Evidence-Based Medicine', 'Faculty', 'Program Development', 'Teaching', 'United States'] | 11,828,582 | [['H02.010'], ['I02.158'], ['I02.358'], ['H02.249.750', 'H02.403.200.400'], ['M01.526.702.250'], ['N04.452.760'], ['I02.903'], ['Z01.107.567.875']] | ['Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. | We previously reported that the anti-epidermal growth factor (EGF) receptor monoclonal antibody (mAb) 225 induces DiFi colon cancer cells to undergo apoptosis, and this apoptosis was accompanied by activation of the two apoptosis initiation caspases, caspase-8 and caspase-9. In the current study, we found that pretreat... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, CD', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Caspase 8', 'Caspase 9', 'Caspase Inhibitors', 'Caspases', 'Enzyme Activation', 'ErbB Receptors', 'Humans', 'Jurkat Cells', 'Membrane Glycoproteins', 'Mice', 'Receptors, TNF-Related Apoptosis-Inducing Ligand', 'Receptor... | 11,439,335 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.035', 'D23.101.100.110'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['D08.811.277.656.262.500.126.550.800', 'D08.811.277.656.300.200.126.550.800', 'D12.644.360.024.285.037', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Radiologic assessment of metastases to the thyroid gland. | PURPOSE: We reviewed the radiologic and clinical data in patients with metastatic disease to the thyroid gland and assessed the role of radiologic techniques in this disorder.METHOD: The findings on US (n = 11), CT (n = 7), MRI (n = 6), palpation or US-guided fine needle aspiration (FNA) biopsy, and clinical records we... | ['Adult', 'Aged', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Retrospective Studies', 'Thyroid Gland', 'Thyroid Neoplasms', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 10,966,183 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['A06.... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Clerkship in general practice--organized for learning?]. | BACKGROUND: Clerkship in general practice has been considered removed from the fifth year at the University of Oslo for economical reasons. During the autumn 2007, we evaluated the clerkship after the implementation of a new feedback tool, StudPEP. This study presents how the clerkship was organized for learning based ... | ['Clinical Clerkship', 'Clinical Competence', 'Family Practice', 'Humans', 'Learning', 'Norway', 'Preceptorship', 'Program Evaluation', 'Surveys and Questionnaires', 'Teaching'] | 19,096,467 | [['I02.358.105'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['Z01.542.816.374'], ['I02.358.968'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Training on selected self-management techniques and the generalization and maintenance of interpersonal skills for registered nurse students. | This study examined the effects of training on selected self-management procedures (post-workshop practice, self-monitoring, self-assessment, and self-reinforcement) on the generalization and maintenance of interpersonal skills with a group of registered nurse students. The findings indicate that those self-management ... | ['Adolescent', 'Adult', 'Attitude of Health Personnel', 'Education, Nursing, Baccalaureate', 'Empathy', 'Female', 'Humans', 'Male', 'Nurse-Patient Relations', 'Self-Assessment', 'Students, Nursing'] | 3,035,125 | [['M01.060.057'], ['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['I02.358.462.316'], ['F01.752.355', 'F01.752.543.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.650.600', 'N05.300.660.560'], ['F01.752.747.792.537'], ['M01.848.769.685']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Antioxidants improve impaired insulin-mediated glucose uptake and prevent migration and proliferation of cultured rabbit coronary smooth muscle cells induced by high glucose. | BACKGROUND: To explore the role of intracellular oxidative stress in high glucose-induced atherogenesis, we examined the effect of probucol and/or alpha-tocopherol on the migration and growth characteristics of cultured rabbit coronary vascular smooth muscle cells (VSMCs).METHODS AND RESULTS: Chronic high-glucose-mediu... | ['Animals', 'Antioxidants', 'Becaplermin', 'Biological Transport, Active', 'Cell Cycle', 'Cell Division', 'Cell Movement', 'Cells, Cultured', 'Coronary Vessels', 'Enzyme Activation', 'Enzyme Inhibitors', 'Flow Cytometry', 'Fructose', 'Glucose', 'Insulin', 'Insulin Resistance', 'Muscle, Smooth, Vascular', 'NAD', 'Naphth... | 10,077,523 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D12.644.276.910.650.500', 'D12.776.260.690.500', 'D12.776.467.910.650.500', 'D23.529.910.650.500'], ['G03.143.310'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.198', 'G07.568.500.180'], ['A11... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early communication development in children with Rett syndrome. | This retrospective pilot study investigated the course of pre-linguistic and linguistic communication development in children with Rett syndrome (RS) from birth to 24 months of age. Parents of 17 children with RS completed a questionnaire based on the Clinical Linguistic Auditory Milestone Scale. No child exceeded sing... | ['Child, Preschool', 'Communication', 'Gestures', 'Humans', 'Infant', 'Language Development', 'Pilot Projects', 'Retrospective Studies', 'Rett Syndrome', 'Speech'] | 8,891,232 | [['M01.060.406.448'], ['F01.145.209', 'L01.143'], ['F01.145.209.530.538.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F01.525.200.310'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The effect of alpha-tocopherol and ascorbic acid on the serum lipid peroxide level in elderly people. | The aim of this work was to study the relationship between the state of saturation of the organism with vitamin E and vitamin C and the serum level of lipid peroxides in elderly people. The determinations were carried out in 100 subjects, mainly women, aged 60-100 years living in old people's homes, who were given dail... | ['Aged', 'Ascorbic Acid', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Lipid Peroxides', 'Male', 'Middle Aged', 'Time Factors', 'Vitamin E'] | 6,732,187 | [['M01.060.116.100'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600', 'D02.389.338.450', 'D10.440'], ['M01.060.116.630'], ['G01.910.857'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pest control by the release of insects carrying a female-killing allele on multiple loci. | With recent advances in genetics, many new strategies for pest control have become feasible. This is the second article in which we model new techniques for pest control based on the mass release of genetically modified insects. In this article we model the release of insects carrying a dominant and redundant female ki... | ['Alleles', 'Animals', 'Female', 'Gene Frequency', 'Genes, Lethal', 'Genetic Engineering', 'Insect Control', 'Insecta', 'Male', 'Pest Control, Biological', 'Population Density', 'Sterilization, Reproductive'] | 11,142,283 | [['G05.360.340.024.340.030'], ['B01.050'], ['G05.330'], ['G05.360.340.024.340.350'], ['E05.393.420'], ['N06.850.780.200.650.425'], ['B01.050.500.131.617'], ['N06.850.780.200.650.650'], ['N01.224.600', 'N06.850.505.400.600'], ['E02.875.194.910', 'E04.950.599']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Comparative analysis of clinical and laboratory methods for diagnosing streptococcal sore throat]. | OBJECTIVES: Diagnosis and correct treatment of group A streptococcal sore throat is important particularly to prevent non-suppurative sequelae. Clinical findings continue to be used to differentiate streptococcal infection from viral sore throat. The American Academy of Pediatrics recommends that streptococcal sore thr... | ['Adolescent', 'Bacterial Typing Techniques', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Likelihood Functions', 'Male', 'Pharyngitis', 'Predictive Value of Tests', 'Prospective Studies', 'Reagent Kits, Diagnostic', 'Sensitivity and Specificity', 'Streptococcal Infections', 'Streptococcus pyogenes', 'Tonsillitis'... | 15,742,082 | [['M01.060.057'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Correlation of clinical data with fallopian tube specimen immune cells and tissue culture capacity. | Human fallopian tube fimbria secretory epithelial cells (hFTSECs) are considered an origin of ovarian cancer and methods for their culture from fallopian tube specimens have been reported. Our objective was to determine whether characteristics of the donors or surgeries were associated with the capacities of fimbria sp... | ['Adult', 'Aged', 'Carcinoma, Ovarian Epithelial', 'Cell Culture Techniques', 'Cell Line, Tumor', 'Epithelial Cells', 'Fallopian Tubes', 'Female', 'Humans', 'Middle Aged', 'Neoplasms, Glandular and Epithelial', 'Ovarian Neoplasms', 'Salpingectomy', 'Specimen Handling'] | 29,857,829 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.295', 'C04.588.322.455.199', 'C13.351.500.056.630.705.350', 'C13.351.937.418.685.350', 'C19.344.410.199', 'C19.391.630.705.350'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.436'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Tissue polypeptide antigen in gynecological cancer]. | Serum tissue polypeptide antigen (TPA), CEA and IAP were measured simultaneously in cervical cancer, corpus cancer and ovarian cancer. TPA levels were increased (more than 110 U/1) in 39% (32/82) of the cervical cancer and in 46% (6/12) of the corpus cancer patients, respectively. In ovarian cancer, TPA levels were ele... | ['Adenocarcinoma', 'Adult', 'Carcinoembryonic Antigen', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Neoplasm Proteins', 'Ovarian Neoplasms', 'Phorbols', 'Tetradecanoylphorbol Acetate', 'Uterine Cervical Neoplasms', 'Uterine Neoplasms'] | 3,981,803 | [['C04.557.470.200.025'], ['M01.060.116'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.624'], ['C04.588.322.455', 'C13.351.500.056.630.705',... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Involvement of the Ca(2+)-dependent phosphorylation of a 20 kDa protein in the proliferative effect of high-density lipoproteins (subclass 3) on the adenocarcinoma cell line A549. | Previous studies from our laboratory demonstrated that high-density lipoproteins (subclass 3; HDL3) bind to sites specific for apolipoprotein AI on the human adenocarcinoma cell line A549 and that HDL3 binding promotes a mitogenic effect [Favre, Tazi, Le Gaillard, Bennis, Hachem and Soula (1993) J. Lipid Res. 34, 1093-... | ['Adenocarcinoma', 'Calcimycin', 'Calcium', 'Cell Division', 'Down-Regulation', 'Humans', 'Lipoproteins, HDL', 'Phosphorylation', 'Protein Kinase C', 'Proteins', 'Tumor Cells, Cultured'] | 7,733,897 | [['C04.557.470.200.025'], ['D03.633.100.221.173'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.432', 'D12.776.521.479'], ['G0... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Injury control. What psychologists can contribute. | Psychologists are inadequately represented in the injury control field, despite the size of the problem and the importance of behavioral factors in injury. Using motor vehicle injuries as an example, this article discusses modern injury control principles and the role psychologists can play in injury reduction. | ['Accident Prevention', 'Accidents, Traffic', 'Health Behavior', 'Humans', 'Safety', 'United States', 'Wounds and Injuries'] | 1,510,332 | [['N06.850.135.060'], ['N06.850.135.392'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.135.060.075'], ['Z01.107.567.875'], ['C26']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Faisability of foetal monitoring in prehospital care]. | The use of mobile monitoring system for foetal cardiotachometry has never been evaluated in the prehospital care. The aim of the survey was to evaluate the faisability of this device. Twenty-five patients were enrolled, mostly within the context of interhospital transfer because of threatening premature delivery (n = 2... | ['Adult', 'Eclampsia', 'Emergency Medical Services', 'Feasibility Studies', 'Female', 'Fetal Monitoring', 'Heart Rate, Fetal', 'Humans', 'Obstetric Labor, Premature', 'Pregnancy', 'Prospective Studies', 'Transportation of Patients'] | 15,949,913 | [['M01.060.116'], ['C13.703.395.124'], ['N02.421.297'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E01.370.378.230', 'E01.370.520.230'], ['G09.330.380.500.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.420.491'], ['G08.686.784.769'], ['E05.318.372.500.750.625'... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Anti-metallothionein IgG and levels of metallothionein in autistic families. | Metallothioneins (MTs) are a family of small proteins containing 61-68 amino acids with an unusually high concentration of cysteine. MT-1, the most functional and active MT in humans, has the ability to react with and enhance the detoxification of a number of metals including zinc, mercury, copper and cadmium. MT dysfu... | ['Autistic Disorder', 'Autoantibodies', 'Enzyme-Linked Immunosorbent Assay', 'Family', 'Humans', 'Immunoglobulin G', 'Metallothionein'] | 18,365,350 | [['F03.625.164.113.500'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Androgens regulate prostate cancer cell growth via an AMPK-PGC-1á-mediated metabolic switch. | Prostate cancer is the most commonly diagnosed malignancy among men in industrialized countries, accounting for the second leading cause of cancer-related deaths. Although we now know that the androgen receptor (AR) is important for progression to the deadly advanced stages of the disease, it is poorly understood what ... | ['AMP-Activated Protein Kinases', 'Androgens', 'Animals', 'Blotting, Western', 'Cell Line, Tumor', 'Cell Proliferation', 'Cell Survival', 'Glycolysis', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Metribolone', 'Mice, Knockout', 'Mice, Transgenic', 'Microscopy, Electron, Transmission', 'Microscopy, Fluorescence', 'Mitoc... | 24,186,207 | [['D08.811.913.696.620.682.700.085', 'D12.644.360.062', 'D12.776.476.062'], ['D27.505.696.399.472.161'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['G02.11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Aptamer Internalization via Endocytosis Inducing S-Phase Arrest and Priming Maver-1 Lymphoma Cells for Cytarabine Chemotherapy. | The goal of precision therapy is to efficiently treat cancer without side effects. Aptamers are a class of small ligands composed of single-stranded oligonucleotides that bind to their targets with high affinity and specificity. In this study, we identified an ssDNA aptamer specifically targeting Maver-1 lymphoma cells... | ['Antimetabolites, Antineoplastic', 'Aptamers, Nucleotide', 'B-Lymphocytes', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Proliferation', 'Cytarabine', 'Endocytosis', 'Humans'] | 28,435,459 | [['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['D13.695.578.424.224'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.144.109'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D03... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phylogenetic analysis of the mitochondrial genomes in bees (Hymenoptera: Apoidea: Anthophila). | In this study, the first complete mitogenome of Andrenidae, namely Andrena camellia, is newly sequenced. It includes 13 protein-coding (PCG) genes, 22 transfer RNA (rRNA) genes, two ribosomal RNA (tRNA) genes, and a control region. Among PCGs, high conservation is observed in cytochrome oxidase genes with cox1 exhibits... | ['Animals', 'Bees', 'Genome, Mitochondrial', 'Models, Genetic', 'Phylogeny', 'Sequence Analysis'] | 30,092,091 | [['B01.050'], ['B01.050.500.131.617.720.500.500.875.387'], ['G05.360.340.360'], ['E05.599.395.397'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.760']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes. | Dendritic cells (DCs) are professional antigen-presenting cells that are highly effective adjuvants for immunizing against pathogens and tumor antigens. The potential merit of genetic approaches to loading DCs with antigens is to express high and sustained levels of proteins that can be subsequently processed and prese... | ['CD4-Positive T-Lymphocytes', 'Cell Differentiation', 'Cytotoxicity Tests, Immunologic', 'DNA, Viral', 'Dendritic Cells', 'Epitopes', 'Genetic Vectors', 'Humans', 'Lentivirus', 'Monocytes', 'Peptide Fragments', 'T-Lymphocytes, Cytotoxic', 'Transduction, Genetic', 'Viral Matrix Proteins'] | 11,133,750 | [['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['G04.152'], ['E01.370.225.812.160', 'E05.200.812.160', 'E05.478.594.160', 'E05.940.245'], ['D13.444.308.568'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['D23.050.550'], ['G05.360.337'], ['B0... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Analysis of causes of death in patients hospitalized in the department of pneumonology]. | UNLABELLED: The number of deaths (188 in total; 102 male, 86 female) noted in the Department of Pneumonology, Medical University of Warsaw in 2010 was the highest in the University Hospital. The mortality rate was 4.7% and this ranked us fifth in our hospital. The aim of the study was to analyze the causes of death and... | ['Aged', 'Aged, 80 and over', 'Cardiovascular Diseases', 'Cause of Death', 'Comorbidity', 'Female', 'Humans', 'Male', 'Middle Aged', 'Poland', 'Pulmonary Medicine', 'Respiratory Tract Diseases', 'Retrospective Studies', 'Survival Rate'] | 22,708,277 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['N05.715.350.225', 'N06.850.490.687'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.248.679'], ['H02.403.429.675']... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Dynamic and thermodynamic characteristics associated with the glass transition of amorphous trehalose-water mixtures. | The glass transition temperature Tg of biopreservative formulations is important for predicting the long-term storage of biological specimens. As a complementary tool to thermal analysis techniques, which are the mainstay for determining Tg, molecular dynamics simulations have been successfully applied to predict the T... | ['Glass', 'Molecular Dynamics Simulation', 'Thermodynamics', 'Trehalose', 'Water'] | 24,803,351 | [['J01.637.437'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G01.906'], ['D09.698.365.900', 'D09.698.629.305.880', 'D09.947.750.880'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Too many simple clerical scoring errors: the Rey Figure as an example. | The clerical errors from 325 scored Rey Figure drawings were tabulated using the procedures outlined in the Boston Qualitative Scoring System manual. The error types investigated were avoidable quantitative scoring errors (e.g., addition, using conversion tables, and plotting scores). The three scorers made errors on 1... | ['Diagnostic Errors', 'Humans', 'Neuropsychological Tests', 'Observer Variation', 'Professional Competence', 'Psychology'] | 10,775,049 | [['E01.354', 'N02.421.450.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['I02.399.630'], ['F04.096.628']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
[Peculiarities of H3-muscimol binding to neocortex membranes of rats exposed to the effects of ethanol in the prenatal period]. | White rats were subjected to ethanol exposure during 5-20 days of pregnancy. 3H-muscimol binding with synaptosomal neocortex membranes yielded from two month age offsprings was studied. 3H-muscimol binding level for experimental animals was 27% more than for control ones. Possible ways of GABAergic system malformation ... | ['Age Factors', 'Animals', 'Cerebral Cortex', 'Ethanol', 'Female', 'Male', 'Muscimol', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Receptors, GABA-A', 'Synaptosomes'] | 2,847,833 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['A08.186.211.200.885.287.500'], ['D02.033.375'], ['D03.383.129.462.470', 'D23.946.587.587'], ['G08.686.784.769'], ['C13.703.824.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.157.530.400.175.562', 'D12.776.157.530.400.400.100.100', 'D12.776.543.550.4... | ['Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Genetic analysis of the larval secretion gene Sgs-4 and its regulatory chromosome sites in Drosophila melanogaster. | Larval salivary gland secretion from seven wild-type stocks of Drosophila melanogaster was electrophoretically analyzed. Considerable variability occurs in the X-chromosomally coded secretion protein 4, both qualitatively, as expressed by differences in electrophoretic mobilities, and quantitatively as seen by its rela... | ['Animals', 'Chromosome Mapping', 'Drosophila melanogaster', 'Electrophoresis, Polyacrylamide Gel', 'Female', 'Genes', 'Genetic Variation', 'Larva', 'Male', 'Salivary Proteins and Peptides'] | 6,799,262 | [['B01.050'], ['E05.393.183'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['E05.196.401.402', 'E05.301.300.319'], ['G05.360.340.024.340'], ['G05.365'], ['B05.500.500', 'G07.345.500.550.500.500'], ['D12.644.848', 'D12.776.850']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
p.His165Pro: a novel SOX9 missense mutation of campomelic dysplasia. | Campomelic dysplasia (CD) is a rare skeletal dysplasia caused by mutation in the SOX9 gene located on chromosome 17q24.3-q25.1, which regulates testis and chondrocyte development. Severe bowing of the long bones was seen at second-trimester scan. DNA analysis demonstrated a previously unreported de novo missense mutati... | ['Abortion, Eugenic', 'Adult', 'Amino Acid Substitution', 'Campomelic Dysplasia', 'Chorionic Villi Sampling', 'Female', 'Humans', 'Mutation, Missense', 'Pregnancy', 'Pregnancy Trimester, First', 'SOX9 Transcription Factor', 'Ultrasonography, Prenatal'] | 23,551,858 | [['E04.520.050.050'], ['M01.060.116'], ['E05.393.420.601.035', 'G05.558.109'], ['C05.660.142', 'C16.131.621.142'], ['E01.370.225.500.384.100.149', 'E01.370.225.998.054.149', 'E01.370.378.630.150', 'E01.370.388.100.150', 'E04.074.149', 'E05.200.500.384.100.149', 'E05.200.998.054.149', 'E05.242.384.100.149'], ['B01.050.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Unique Phase Transition of Exogenous Fusion Elastin-like Polypeptides in the Solution Containing Polyethylene Glycol. | Elastin-Like polypeptides (ELPs), as well-known temperature-controlled bio-macromolecules, are widely used. However, little is known about the interactions between ELPs and macromolecules, which is an important yet neglected problem. Here, the phase transition characteristics of an ELPs-SpyCatcher fusion protein (E-C) ... | ['Elastin', 'Peptides', 'Phase Transition', 'Polyethylene Glycols', 'Spectrometry, Fluorescence', 'Spectrophotometry, Ultraviolet', 'Transition Temperature'] | 31,330,842 | [['D05.750.078.421', 'D12.776.860.300.350'], ['D12.644'], ['G01.645', 'G02.734'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['G01.906.595.850']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Script differences and masked translation priming: Evidence from Hindi-English bilinguals. | This study reports on two experiments investigating the effects of script differences on masked translation priming in highly proficient early Hindi-English bilinguals. In Experiment 1 (the cross-script experiment), L1 Hindi was presented in the standard Devanagari script, while L2 English was presented in the Roman al... | ['Association Learning', 'Female', 'Humans', 'Male', 'Multilingualism', 'Reaction Time', 'Repetition Priming', 'Semantics', 'Translations', 'Vocabulary'] | 30,362,410 | [['F02.463.425.069.296'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.423.452'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F02.463.425.540.739'], ['L01.559.598.745'], ['L01.178.682.920'], ['L01.559.598.901']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Intersection between the regulators of sister chromatid cohesion establishment and maintenance in budding yeast indicates a multi-step mechanism. | Sister chromatid cohesion is established during S phase and maintained until anaphase. The cohesin complex (Mcd1p/Scc1p, Smc1p, Smc3p Irr1p/Scc3p in budding yeast) serves a structural role as it is required at all times when cohesion exists. Pds5p colocalizes temporally and spatially with cohesin on chromosomes but is ... | ['Alleles', 'Cell Cycle Proteins', 'Chondroitin Sulfate Proteoglycans', 'Chromatin', 'Chromosomal Proteins, Non-Histone', 'Chromosome Segregation', 'Chromosomes', 'Gene Expression Regulation, Fungal', 'Mutation', 'Nuclear Proteins', 'Phosphoproteins', 'S Phase', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Pro... | 17,102,636 | [['G05.360.340.024.340.030'], ['D12.776.167'], ['D09.698.735.200', 'D12.776.395.650.750'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D12.776.660.235', 'D12.776.664.235'], ['G04.144.220.220.625', 'G05.113.220.625'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['G... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
DNA polymorphisms at the locus for human cholesteryl ester transfer protein (CETP) are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus. | The effect of variation at the cholesteryl ester transfer protein (CETP) gene locus and in the apolipoprotein (apo) AI-CIII-AIV gene cluster on the susceptibility of individuals with non-insulin-dependent diabetes mellitus (NIDDM) to atherosclerotic vascular disease was studied in 136 male and 122 female patients with ... | ['Adult', 'Aged', 'Base Sequence', 'Carrier Proteins', 'Cholesterol Ester Transfer Proteins', 'DNA', 'Diabetes Mellitus, Type 2', 'Diabetic Angiopathies', 'Female', 'Genotype', 'Glycoproteins', 'Haplotypes', 'Humans', 'Male', 'Middle Aged', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Polymorphism, Genetic'... | 7,820,935 | [['M01.060.116'], ['M01.060.116.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157'], ['D09.400.430.750', 'D12.776.124.197', 'D12.776.157.165', 'D12.776.395.199'], ['D13.444.308'], ['C18.452.394.750.149', 'C19.246.300'], ['C14.907.320', 'C19.246.099.500'], ['G05.380'], ['D09.400.430', 'D12.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The effect of metrifonate in mixed Schistosoma haematobium and Schistosoma mansoni infections in humans. | In order to examine the effect of metrifonate, 156 patients with mixed Schistosoma haematobium and mansoni infection were randomly divided into three groups and treated with metrifonate (twice 10 mg/kg body weight), oxamniquine (60 mg/kg) and praziquantel (40 mg/kg), respectively. The output of S. haematobium and S. ma... | ['Adolescent', 'Child', 'Clinical Trials as Topic', 'Feces', 'Humans', 'Lung', 'Male', 'Oxamniquine', 'Parasite Egg Count', 'Praziquantel', 'Random Allocation', 'Schistosomiasis haematobia', 'Schistosomiasis mansoni', 'Trichlorfon'] | 3,082,230 | [['M01.060.057'], ['M01.060.406'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['D03.633.100.810.350.600', 'D03.633.100.810.470.600'], ['E01.370.225.932.600', 'E05.200.932.600'], ['D03.633.100.531.690'], ['E05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of aging on biological properties of periodontal ligament cells. | The majority of patients eligible for periodontal regenerative therapies are aged subjects. Since periodontal ligament cells (PDLC) are essential for periodontal regeneration, the aim of the present study was to determine the effect of cellular aging on PDLC, including genes associated with extracellular matrix metabol... | ['Adolescent', 'Aged', 'Aging', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Extracellular Matrix Proteins', 'Female', 'Gene Expression', 'Humans', 'Male', 'Middle Aged', 'Periodontal Ligament', 'Tooth Calcification', 'Young Adult'] | 19,085,240 | [['M01.060.057'], ['M01.060.116.100'], ['G07.345.124'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['D12.776.860.300'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A14.549.167.646.771'], ['G07.345.155.500.710', 'G10.549.800'], ['M01.060.116.815']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Extraction, characterization and biological activity of a (1,3)(1,6)-â-d-glucan from the pathogenic oomycete Pythium insidiosum. | Pythiosis is a life-threatening infectious disease caused by the pathogenic oomycete Pythium insidiosum. This study is the first to evaluate the P. insidiosum glucan content and its biological activities. The enzymatic quantification of the glucans in P. insidiosum mycelia showed that the â-glucan content was 18.99%±3.... | ['Animals', 'Cells, Cultured', 'Cytokines', 'Glucans', 'Horses', 'Humans', 'Immunity, Cellular', 'Mice', 'Mice, Inbred BALB C', 'Monosaccharides', 'Polysaccharides', 'Pythium', 'Spleen', 'Th17 Cells'] | 27,987,983 | [['B01.050'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D05.750.078.562', 'D09.698.365'], ['B01.050.150.900.649.313.984.235.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.9... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison between mass transfer properties of weak-anion-exchange resins with graft-functionalized polymer layers and traditional ungrafted resins. | Glycidylmethacrylate was grafted to Toyopearl HW-65M and subsequently modified with diethylamine to obtain a weak anion exchanger. The degree of grafting was varied from 11 to 50%. The binding capacity for bovine serum albumin was 11 mg/ml for the lowest degree of grafting and 97 mg/ml for the highest degree of graftin... | ['Anion Exchange Resins', 'Chromatography, Gel', 'Diethylamines', 'Muramidase', 'Polymers', 'Thermodynamics'] | 12,938,888 | [['D27.720.470.420.050'], ['E05.196.181.400.250'], ['D02.092.471.302'], ['D08.811.277.450.642'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin. | We have recently developed antisera which recognize epitopes of the cloned delta-opioid receptor (DOR; Dado et al., 1993). In the present report we have further characterized these antisera, and raised additional antisera in rats. We used these antisera to determine the distribution of DOR-like immunoreactivity (-Ll) i... | ['Amino Acid Sequence', 'Animals', 'Biogenic Amines', 'Brain Stem', 'Enkephalins', 'Epitopes', 'Immune Sera', 'Male', 'Molecular Sequence Data', 'Peptide Fragments', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Opioid, delta', 'Receptors, sigma', 'Serotonin', 'Spinal Cord', 'Tissue Distribution', 'Tyrosine 3-Monooxygena... | 7,532,700 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D02.092.211'], ['A08.186.211.132'], ['D12.644.400.575.281', 'D12.776.631.650.575.281'], ['D23.050.550'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], ['L01.453.245.667'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Novel Stenotrophomonas maltophilia temperate phage DLP4 is capable of lysogenic conversion. | BACKGROUND: Temperate bacteriophages are capable of lysogenic conversion of new bacterial hosts. This phenomenon is often ascribed to "moron" elements that are acquired horizontally and transcribed independently from the rest of the phage genes. Whereas some bacterial species exhibit relatively little prophage-dependen... | ['Bacteriophages', 'DNA Repair', 'DNA Replication', 'Genome, Viral', 'Morphogenesis', 'Phenotype', 'Soil Microbiology', 'Stenotrophomonas maltophilia', 'Tetrahydrofolate Dehydrogenase'] | 30,991,961 | [['B04.123'], ['G02.111.222', 'G05.219'], ['G02.111.225', 'G05.226'], ['G05.360.340.358.840'], ['G07.345.500'], ['G05.695'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['B03.440.400.425.967.750.500', 'B03.660.250.915.750.500'], ['D08.811.682.662.825']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Cloning, heterologous expression, and enzymatic characterization of a thermostable glucoamylase from Talaromyces emersonii. | The gene encoding a thermostable glucoamylase from Talaromyces emersonii was cloned and, subsequently, heterologously expressed in Aspergillus niger. This glucoamylase gene encodes a 618 amino acid long protein with a calculated molecular weight of 62,827Da. T. emersonii glucoamylase fall into glucoside hydrolase famil... | ['Aspergillus niger', 'Cloning, Molecular', 'Enzyme Stability', 'Gene Expression', 'Glucan 1,4-alpha-Glucosidase', 'Glucans', 'Hydrogen-Ion Concentration', 'Isomaltose', 'Kinetics', 'Maltose', 'Molecular Sequence Data', 'Recombinant Fusion Proteins', 'Substrate Specificity', 'Talaromyces', 'Temperature'] | 12,356,463 | [['B01.300.381.081.450'], ['E05.393.220'], ['E05.916.360', 'G02.111.700.500'], ['G05.297'], ['D08.811.277.450.420.375'], ['D05.750.078.562', 'D09.698.365'], ['G02.300'], ['D09.698.365.410', 'D09.698.629.305.320', 'D09.947.750.320'], ['G01.374.661', 'G02.111.490'], ['D09.698.365.450', 'D09.698.629.305.523', 'D09.947.750... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Macro-level approaches to HIV prevention among ethnic minority youth: state of the science, opportunities, and challenges. | The HIV epidemic continues to disproportionately affect ethnic minority youth. These disconcerting health disparities indicate that although existing HIV preventive strategies for ethnic minority youth have been efficacious, they have not significantly reduced the impact of the epidemic in this population. Macro-level ... | ['Adolescent', 'Epidemics', 'HIV Infections', 'Health Status Disparities', 'Humans', 'Minority Groups'] | 23,688,095 | [['M01.060.057'], ['N06.850.290.200'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.853.300']] | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging. | Mosquito blood cells are immune cells that help control infection by vector-borne pathogens. Despite their importance, little is known about mosquito blood cell biology beyond morphological and functional criteria used for their classification. Here, we combined the power of single-cell RNA sequencing, high-content ima... | ['Animals', 'Animals, Genetically Modified', 'Anopheles', 'Blood Cells', 'Cell Communication', 'Cell Plasticity', 'Datasets as Topic', 'Female', 'Genomics', 'Malaria', 'Mosquito Vectors', 'RNA', 'Sequence Analysis, RNA', 'Single-Cell Analysis', 'Transcriptome'] | 30,038,005 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['B01.050.500.131.617.720.500.500.750.712.500.875.120'], ['A11.118', 'A15.145.229'], ['G04.085'], ['G04.356.250'], ['E05.318.308.056', 'L01.313.500.750.300.188.400.500', 'L01.399.250.224', 'L01.470.750.750.431', 'N05.715.360.300.224', 'N06.850.520.308.056'], ['H01.158.2... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Minimally invasive treatment for distal radial fracture and dislocation of type IV based on Fernandez classification]. | OBJECTIVE: To investigate the effects of external fixation combined with minimally invasive internal fixation for the treatment of distal radial fracture and dislocation of type IV based on Fernandez classification.METHODS: From January 2007 to October 2012,19 patients with the distal radius fracture and dislocation of... | ['Adult', 'Bone Nails', 'Female', 'Fracture Fixation, Internal', 'Humans', 'Joint Dislocations', 'Male', 'Minimally Invasive Surgical Procedures', 'Radius Fractures', 'Range of Motion, Articular', 'Treatment Outcome', 'Wrist Injuries', 'Wrist Joint', 'Young Adult'] | 25,029,846 | [['M01.060.116'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['E04.555.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.518', 'C26.289'], ['E04.502'], ['C26.088.268.556', 'C26.404.562'], ['E01.370.600.700', 'G11.427.760'], ['E01.789.800', 'N04.761.559.590.800', 'N05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Association of median household income with burden of coronary artery disease among individuals with diabetes. | BACKGROUND: Low income is associated with adverse cardiovascular outcomes. Diabetes is more prevalent among low income groups, and low income patients with diabetes have been shown to have a greater burden of cardiovascular risk factors and worse cardiovascular outcomes. The objective of this study was to determine whe... | ['Aged', 'Alberta', 'Chi-Square Distribution', 'Coronary Angiography', 'Coronary Artery Disease', 'Diabetes Complications', 'Family Characteristics', 'Female', 'Humans', 'Income', 'Linear Models', 'Male', 'Middle Aged', 'Registries', 'Risk Assessment', 'Risk Factors', 'Severity of Illness Index', 'Social Class'] | 20,123,671 | [['M01.060.116.100'], ['Z01.107.567.176.064'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C19.246.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. | Gamma-aminobutyric acid A (GABAA) receptors are the principal mediators of synaptic inhibition, and yet when intensely activated, dendritic GABAA receptors excite rather than inhibit neurons. The membrane depolarization mediated by GABAA receptors is a result of the differential, activity-dependent collapse of the oppo... | ['Acetazolamide', 'Amiloride', 'Animals', 'Bicarbonates', 'Chlorides', 'Dendrites', 'Hydrogen-Ion Concentration', 'In Vitro Techniques', 'Magnesium', 'Membrane Potentials', 'Muscimol', 'Neurons', 'Pyramidal Cells', 'Rats', 'Receptors, GABA-A', 'Receptors, N-Methyl-D-Aspartate', 'Synapses', 'gamma-Aminobutyric Acid'] | 7,638,623 | [['D02.886.675.867.060', 'D03.383.129.708.867.060'], ['D03.383.679.149'], ['B01.050'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['D01.210.450.150', 'D01.248.497.158.215'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['G02.300'], ['E05.481'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preimplantation genetic screening to improve in vitro fertilization pregnancy rates: a prospective randomized controlled trial. | This prospective randomized controlled pilot trial was designed to evaluate whether prescreening embryos for aneuploidy can improve clinical outcomes in infertile patients undergoing IVF, without limiting to poor prognosis patients. Although there was no statistically significant improvement in live birth rates or impl... | ['Adult', 'Female', 'Fertilization in Vitro', 'Genetic Testing', 'Humans', 'Incidence', 'Infertility', 'Middle Aged', 'Pregnancy', 'Pregnancy Outcome', 'Preimplantation Diagnosis', 'Prospective Studies', 'Treatment Outcome'] | 18,061,593 | [['M01.060.116'], ['E02.875.800.750', 'E05.820.800.750'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C12.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The influence of melatonin on the content of vasopressin and oxytocin in the hypothalamus and neurohypophysis in euhydrated and dehydrated male rats. | Melatonin injected in a single intraperitoneal dose of 100 micrograms/100 g b.w. to euhydrated rats resulted in a decrease of neurohypophysial oxytocin content but the hypothalamic oxytocin storage as well as the hypothalamo-neurohypophysial storage of vasopressin were not changed. Following 8 d of once-daily melatonin... | ['Animals', 'Hypothalamus', 'Male', 'Melatonin', 'Oxytocin', 'Pituitary Gland, Posterior', 'Rats', 'Rats, Inbred Strains', 'Water-Electrolyte Balance'] | 3,772,720 | [['B01.050'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['D03.633.100.473.914.481', 'D06.472.506'], ['D06.472.699.631.692.433', 'D12.644.548.691.692.433'], ['A06.300.747.875', 'A06.688.178.875', 'A06.688.357.750.875', 'A08.186.211.180.497.352.435.500.875', 'A08.186.211.200.317.357.352.435.500.875', 'A08.713.0... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of low-birth-weight breech delivery on neonatal mortality. | The influence of breech presentation on neonatal mortality was studied in 77 viable low-birth-weight breech deliveries. Neonates were divided into 3 weight groups: 1000-1499 g, 1500-1999 g, and 2000-2499 g. The antepartum and intrapartum characteristics of the 3 weight groups were detailed. The 17 neonates who died wer... | ['Adult', 'Breech Presentation', 'Delivery, Obstetric', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Infant Mortality', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Labor Presentation', 'Obstetric Labor Complications', 'Pregnancy', 'Pregnancy Complications', 'Respiratory Distress Syndrome, Newborn', 'Time Fac... | 572,025 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multicystic ovarian tumor weighing 156 lbs: the second largest tumor in Texas. | A woman's lifetime risk of developing an ovarian neoplasm is approximately 7%. A small subset of these neoplasms comprises the gigantic ovarian tumors (> 25 lbs) that often present challenging and difficult problems. We present a case of a 156-lb ovarian tumor with emphasis on the diagnostic and therapeutic approaches ... | ['Cystadenoma, Mucinous', 'Female', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Organ Size', 'Ovarian Neoplasms', 'Polycystic Ovary Syndrome', 'Texas', 'Ultrasonography'] | 9,210,846 | [['C04.557.470.035.320.225', 'C04.557.470.590.485.225'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['C04.588.322.45... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Frequency of Secondary Dislocations of Initially non Displaced and Minimally Displaced Fractures of the Lateral Humeral Condyle in Children - Surveillance of a Treatment Algorithm. | AIM OF THE STUDY: The treatment of undisplaced fractures of the lateral humeral condyle is conservative. However, it is problematic that it is not possible to differentiate between a stable and an unstable, non-displaced fracture. A pragmatic approach is to X-ray the elbow without a cast 5 days after trauma and to comp... | ['Algorithms', 'Child', 'Elbow Joint', 'Humans', 'Humeral Fractures', 'Humerus', 'Infant', 'Retrospective Studies'] | 31,117,144 | [['G17.035', 'L01.224.050'], ['M01.060.406'], ['A02.835.583.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.088.390', 'C26.404.500'], ['A02.835.232.087.090.400'], ['M01.060.703'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Characterization of an internal ribosome entry site within mRNA 5 of murine hepatitis virus. | The unique region of mRNA 5 of murine hepatitis virus contains two open reading frames, ORF 5a and ORF 5b. The downstream ORF 5b encodes the envelope (E) protein, an integral membrane protein of the virus. We have shown previously that the expression of ORF 5b is mediated by the internal entry of ribosomes. In the expe... | ['Animals', 'Base Sequence', 'Cell-Free System', 'DNA Primers', 'L Cells', 'Mice', 'Molecular Sequence Data', 'Murine hepatitis virus', 'Open Reading Frames', 'Plasmids', 'Polymerase Chain Reaction', 'Protein Biosynthesis', 'RNA, Messenger', 'RNA, Viral', 'Reverse Transcriptase Polymerase Chain Reaction', 'Ribosomes', ... | 10,416,375 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.835.168'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['A11.251.210.505', 'A11.329.228.505'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['B04.450.580', 'B04.820.578.500.540.150.113.875'], ['G05.36... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Catechol-O-methyltransferase genotype as modifier of superior responses to venlafaxine treatment in major depressive disorder. | Responses to venlafaxine treatment in major depressive disorder were stratified by COMT genotypes (Val158Met, rs4680) in a randomized, double-blind, placebo-controlled clinical trial. Improvements in depression scores among subjects with Val/Val genotypes were larger than those in Met/Met genotypes, suggesting that ven... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Antidepressive Agents, Second-Generation', 'Catechol O-Methyltransferase', 'Cyclohexanols', 'Depressive Disorder, Major', 'Double-Blind Method', 'Female', 'Follow-Up Studies', 'Genotype', 'Humans', 'Male', 'Methionine', 'Middle Aged', 'Pharmacogenetics', 'Polymorphism, G... | 23,706,899 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.954.427.700.122.050'], ['D08.811.913.555.500.250'], ['D02.033.415.510.500', 'D02.455.426.392.368.367.318', 'D10.289.510.500'], ['F03.600.300.375'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
The endoplasmic reticulum (ER)-target protein Bik induces Hep3B cells apoptosis by the depletion of the ER Ca2+ stores. | Bik, a BH3-only protein, was identified to induce cells apoptosis. In this study, we reported that Bik exclusively localized to endoplasmic reticulum rather than mitochondria. The apoptosis induced by Bik was inhibited in Hep3B cells, when TM domain of Bik was truncated. The ectopic overexpression of Bik protein caused... | ['Apoptosis', 'Apoptosis Regulatory Proteins', 'Biological Transport', 'Calcium', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Cytosol', 'Endoplasmic Reticulum', 'Humans', 'Liver Neoplasms', 'Membrane Proteins', 'Mitochondrial Proteins', 'Protein Structure, Tertiary', 'Time Factors', 'Tissue Distribution', 'Transf... | 18,299,962 | [['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Circulating microparticles as indicators of peripartum cardiomyopathy. | AIMS: Peripartum cardiomyopathy (PPCM) is associated with high mortality and morbidity. Endothelial damage involving cathepsin-D to form a 16 kDa prolactin (PRL) peptide is pathogenetically relevant. Inhibiting PRL peptide with bromocriptine has yielded promising results. We investigated whether microparticles (MPs) ca... | ['Adult', 'Analysis of Variance', 'Biomarkers', 'Bromocriptine', 'Cardiomyopathies', 'Case-Control Studies', 'Cell-Derived Microparticles', 'Female', 'Flow Cytometry', 'Hormone Antagonists', 'Humans', 'Pregnancy', 'Puerperal Disorders'] | 22,307,461 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D23.101'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['C14.280.238'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.284.295.588.500'], ['E01.370.225.500.363.342', 'E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Proton pump inhibitor therapy improves symptoms in postnasal drainage. | BACKGROUND & AIMS: Gastroesophageal reflux is common among patients with postnasal drainage. We investigated whether proton pump inhibitor therapy improved symptoms in patients with postnasal drainage without sinusitis or allergies.METHODS: In a parallel-group, double-blind, multi-specialty trial, we randomly assigned ... | ['2-Pyridinylmethylsulfinylbenzimidazoles', 'Adult', 'Chronic Disease', 'Education, Medical, Continuing', 'Enzyme Inhibitors', 'Esophageal pH Monitoring', 'Female', 'Gastroesophageal Reflux', 'Humans', 'Lansoprazole', 'Male', 'Middle Aged', 'Mucus', 'Nasal Mucosa', 'Proton Pump Inhibitors', 'Rhinitis', 'Treatment Outco... | 20,801,120 | [['D02.886.640.074', 'D03.383.725.024', 'D03.633.100.103.034'], ['M01.060.116'], ['C23.550.291.500'], ['I02.358.212.350', 'I02.358.399.250'], ['D27.505.519.389'], ['E01.370.372.255', 'E01.370.520.215'], ['C06.405.117.119.500.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.886.640.074.249', 'D03.383.725.02... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Particulate matter and carbon dioxide in classrooms - the impact of cleaning and ventilation. | UNLABELLED: The objective of the study was to measure the indoor air quality in classrooms with special emphasis on particulate matter (PM 10) and carbon dioxide (CO(2)) and the impact of cleaning and ventilation.MATERIAL AND METHOD: PM 10 was analysed via gravimetric method and by laser beam technology. CO(2) was anal... | ['Air Pollution, Indoor', 'Carbon Dioxide', 'Dust', 'Environmental Restoration and Remediation', 'Germany', 'Humans', 'Particulate Matter', 'Schools', 'Ventilation'] | 18,155,960 | [['N06.850.460.100.080'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D20.633.222'], ['N06.230.080.600', 'N06.850.460.375'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.633'], ['I02.783', 'J03.832'], ['N06.230.150.520']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. | The Saccharomyces cerevisiae general amino-acid permease, Gap1p, is a model for membrane proteins that are regulated by intracellular sorting according to physiological cues set by the availability of amino acids. Here, we report the identification of a conserved sorting complex for Gap1p, named the GTPase-containing c... | ['Amino Acid Motifs', 'Amino Acid Transport Systems', 'Conserved Sequence', 'Endosomes', 'Evolution, Molecular', 'GTP-Binding Proteins', 'Intracellular Membranes', 'Macromolecular Substances', 'Monomeric GTP-Binding Proteins', 'Protein Binding', 'Protein Structure, Tertiary', 'Protein Transport', 'Saccharomyces cerevis... | 16,732,272 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D12.776.157.530.200', 'D12.776.543.585.200'], ['G02.111.570.580'], ['A11.284.430.214.190.875.190.880.337'], ['G05.045.250', 'G16.075.250'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['A11.284.149.450', 'A11.284.835.514'], ['D05'], ['D08.811.277.04... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variability in somatosensory cortical neuron discharge: effects on capacity to signal different stimulus conditions using a mean rate code. | 1. The present study is based on the demonstration (8, 9) that the relationship between mean interval (MI) and standard deviation (SD) for stimulus-driven activity recorded from SI neurons is well fitted by the linear equation SD = a X MI + b and on the observations that the values of the slope (a) and y intercept (b) ... | ['Animals', 'Haplorhini', 'Macaca', 'Neurons', 'Physical Stimulation', 'Somatosensory Cortex', 'Statistics as Topic'] | 418,155 | [['B01.050'], ['B01.050.150.900.649.313.988.400'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['A08.675', 'A11.671'], ['E05.723'], ['A08.186.211.200.885.287.500.670.675', 'A08.186.211.200.885.287.500.814.906'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Regulated heterogeneity in 12-kDa P-protein phosphorylation and composition of ribosomes in maize (Zea mays L.). | Maize (Zea mays L.) possesses four distinct approximately 12-kDa P-proteins (P1, P2a, P2b, P3) that form the tip of a lateral stalk on the 60 S ribosomal subunit. RNA blot analyses suggested that the expression of these proteins was developmentally regulated. Western blot analysis of ribosomal proteins isolated from va... | ['Phosphorylation', 'Plant Proteins', 'Ribosomal Proteins', 'Ribosomes', 'Zea mays'] | 11,278,810 | [['G02.111.665', 'G02.607.780', 'G03.796'], ['D12.776.765'], ['D12.776.835'], ['A11.284.430.214.190.875.811'], ['B01.650.940.800.575.912.250.822.966']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rat liver NAD(P)H:quinone reductase: isolation of a quinone reductase structural gene and prediction of the NH2 terminal sequence of the protein by double-stranded sequencing of exons 1 and 2. | Recently two reports [J. A. Robertson et al. (1986) J. Biol. Chem. 261, 15794-15799 and R. M. Bayney et al. (1987) J. Biol. Chem. 262, 572-575] have appeared concerning the nucleotide sequence of quinone reductase cDNA clones. Although the cDNA clones are virtually identical, they diverge in the 5' region that encodes ... | ['Amino Acid Sequence', 'Animals', 'Bacteriophage lambda', 'Base Sequence', 'DNA', 'DNA, Recombinant', 'Exons', 'Genes', 'Liver', 'Molecular Sequence Data', 'NAD(P)H Dehydrogenase (Quinone)', 'Nucleic Acid Hybridization', 'Oligonucleotides', 'Quinone Reductases', 'RNA, Messenger', 'Rats'] | 2,963,593 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['D13.444.308.460'], ['G05.360.340.024.340.137.232'], ['G05.360.340.024.340'], ['A03.620'], ['L01.453.245.667'], ['D08.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Lyophilization of polyethylene glycol mixtures. | Lyophilization of cosolvent systems may be a beneficial way of enhancing both physical and chemical stability of a drug product. The objective of this research is to establish whether cosolvent systems commonly used in the formulation of poorly water-soluble drugs can be successfully lyophilized. Polyethylene glycol (P... | ['Freeze Drying', 'Pharmaceutical Solutions', 'Polyethylene Glycols'] | 15,295,785 | [['E01.370.225.500.620.760.160.260', 'E01.370.225.750.600.760.160.260', 'E02.792.156.260', 'E05.200.500.620.760.160.260', 'E05.200.750.600.760.160.260', 'E05.760.156.260'], ['D26.776.708', 'D27.505.954.578', 'D27.720.752'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Drugs, narcotics--knowledge and habits in schools]. | During the school session 1988/1989, the school doctors in the County of Roskilde carried out a questionnaire investigation among 4,004 pupils in the seventh and ninth classes about their knowledge, habits and attitudes to euphorising drugs. The questionnaire investigation was voluntary and anonymous and this probably ... | ['Adolescent', 'Child', 'Denmark', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'School Health Services', 'Substance-Related Disorders', 'Surveys and Questionnaires'] | 2,256,212 | [['M01.060.057'], ['M01.060.406'], ['Z01.542.816.124'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.809'], ['C25.775', 'F03.900'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Design of Free Triblock Polylysine- b-Polyleucine- b-Polylysine Chains for Gene Delivery. | Mixing cationic polymer chains with anionic DNA chains in solution results in the polymer/DNA complexes (also known as polyplexes). We recently confirmed that it is those noncomplexed cationic chains free in the mixture that promote the gene transfection, leading to a hypothesis: free cationic chains adsorbed on variou... | ['Anions', 'Cations', 'Gene Transfer Techniques', 'Genetic Vectors', 'Humans', 'Lysosomes', 'Peptides', 'Plasmids', 'Polylysine', 'Polymers'] | 29,505,712 | [['D01.248.497.158'], ['D01.248.497.300'], ['E05.393.350'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.875.190.550'], ['D12.644'], ['G05.360.600'], ['D12.125.068.555.750', 'D12.125.095.647.750', 'D12.644.760'], ['D05.750', 'D25.720', 'J01.637.051.720']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effect of chronic co-administration of morphine and verapamil on isoproterenol-induced heart injury. | OBJECTIVE: Long-term co-administration of morphine and calcium channel antagonists (CCAs) is likely in some clinical conditions. Reciprocal interactions during chronic concomitant use of these agents are confirmed in central nervous system studies. However, there is little information regarding their chronic combinatio... | ['Animals', 'Calcium Channel Blockers', 'Cardiotonic Agents', 'Drug Synergism', 'Heart', 'Heart Injuries', 'Isoproterenol', 'Male', 'Morphine', 'Myocardium', 'Narcotics', 'Rats', 'Rats, Wistar', 'Troponin I', 'Verapamil'] | 21,902,658 | [['B01.050'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D27.505.954.411.222', 'D27.720.799.080'], ['G07.690.773.968.477'], ['A07.541'], ['C26.891.375'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['D03.132.577.249.562.571', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alteration of FHR pattern associated with progressively advanced fetal acidemia caused by cord compression. | In order to investigate changes in FHR when a fetus suffers acidemia, we produced progressively advanced acidemia in lamb fetus by intermittently repeated cord compression. FHR was monitored throughout the study. FHR patterns were classified into five characteristic types as fetal arterial pH fell from around 7.35 to b... | ['Acidosis, Respiratory', 'Animals', 'Female', 'Fetal Hypoxia', 'Heart Rate, Fetal', 'Hydrogen-Ion Concentration', 'Pregnancy', 'Sheep', 'Umbilical Cord'] | 3,392,441 | [['C08.618.846.093', 'C18.452.076.176.310'], ['B01.050'], ['C13.703.277.390', 'C16.300.420', 'C23.888.852.079.594'], ['G09.330.380.500.430'], ['G02.300'], ['G08.686.784.769'], ['B01.050.150.900.649.313.500.380.791'], ['A16.378.693']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus. | Compounds that target the cellular factors essential for influenza virus replication represent an innovative approach to antiviral therapy. Sp2CBMTD is a genetically engineered multivalent protein that masks sialic acid-containing cellular receptors on the respiratory epithelium, which are recognized by influenza virus... | ['Animals', 'Antiviral Agents', 'Carrier Proteins', 'Chemokines', 'Cytokines', 'Female', 'Influenza A Virus, H7N9 Subtype', 'Lung', 'Mice', 'Mice, Inbred BALB C', 'Orthomyxoviridae Infections', 'Receptors, Cell Surface', 'Sialic Acids', 'Virus Replication'] | 25,534,734 | [['B01.050'], ['D27.505.954.122.388'], ['D12.776.157'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['B04.820.480.968.405.400.800'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reducing variation in antibacterial prescribing rates for 'cough/cold' and sore throat between 1993 and 2001: regional analyses using the general practice research database. | OBJECTIVE: To use the General Practice Research Database (GPRD) to explore the regional variation in prescribing for single diagnostic episodes of 'cough/cold' and sore throat and how this changed between 1993 and 2001.METHODS: Data from the GPRD was used to conduct a longitudinal survey of morbidity and antibiotic pre... | ['Anti-Bacterial Agents', 'Common Cold', 'Cough', 'Drug Utilization', 'Humans', 'Longitudinal Studies', 'Pharyngitis', 'Physicians, Family', "Practice Patterns, Physicians'", 'United Kingdom'] | 16,828,131 | [['D27.505.954.122.085'], ['C01.748.162', 'C01.925.782.687.207', 'C08.730.162'], ['C08.618.248', 'C23.888.852.293'], ['N04.452.706.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['C01.748.561', 'C07.550.781', 'C08.730.56... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Purification and characterization of phosphoglycerate mutase from methanol-grown Hyphomicrobium X and Pseudomonas AM1. | Phosphoglycerate mutase has been purified from methanol-grown Hyphomicrobium X and Pseudomonas AMI by acid precipitation, heat treatment, ammonium sulphate fractionation, Sephadex G-50 gel filtration and DEAE-cellulose column chromatography. The purification attained using the Hyphomicrobium X extract was 72-fold, and ... | ['Bacteria', 'Chromatography, DEAE-Cellulose', 'Chromatography, Gel', 'Diphosphoglyceric Acids', 'Drug Stability', 'Hydrogen-Ion Concentration', 'Methanol', 'Molecular Weight', 'Phosphoglycerate Mutase', 'Phosphotransferases', 'Pseudomonas'] | 10,346 | [['B03'], ['E05.196.181.400.383.349'], ['E05.196.181.400.250'], ['D02.241.081.844.387.388', 'D02.241.511.902.387.388', 'D02.705.400.140', 'D09.811.366.388'], ['E05.916.330'], ['G02.300'], ['D02.033.623'], ['G02.494'], ['D08.811.399.520.750.700'], ['D08.811.913.696'], ['B03.440.400.425.625.625', 'B03.660.250.580.590']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nivolumab-Induced Severe Akathisia in an Advanced Lung Cancer Patient. | BACKGROUND Nivolumab is an anti-PD-1 immune checkpoint inhibitor that was recently developed for cancer immunotherapy. In the clinical trials of nivolumab, its adverse effects were reported to be less likely than those of conventional anti-cancer agents; however, after practical clinical distribution, it has come to be... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Akathisia, Drug-Induced', 'Antibodies, Monoclonal', 'Antineoplastic Agents', 'Brain', 'Humans', 'Lung Neoplasms', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Nivolumab'] | 27,893,699 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['C10.228.662.037', 'C10.720.075', 'C23.888.592.350.600.500', 'C25.100.249', 'C25.723.705.100'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D27.505.954.248'], ['A08.186.211'], ['B01.05... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of medical supplies essential for the care of survivors of sex- and gender-based violence in post-conflict Eastern Democratic Republic of Congo. | The fundamental concepts set forth in the formal Post-Conflict Needs Assessment (PCNA) initiative created by the United Nations Development Group have the potential to be adapted to assist local groups in documenting the needs of and the provision of health care to survivors of sex- and gender-based violence (SGBV) in ... | ['Democratic Republic of the Congo', 'Female', 'Health Services Accessibility', 'Health Services Needs and Demand', 'Hospitals', 'Human Rights Abuses', 'Humans', 'Male', 'Needs Assessment', 'Prejudice', 'Primary Health Care', 'Rape', 'Surveys and Questionnaires', 'Survivors', 'United States', 'Violence'] | 22,073,532 | [['Z01.058.290.100.220'], ['N04.590.374.350', 'N05.300.430'], ['N03.349.380.420', 'N05.300.450'], ['N02.278.421'], ['I01.880.735.384'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.594', 'N03.349.380.565', 'N05.300.537'], ['F01.145.813.550', 'F01.829.595'], ['N04.590.233.727'], ['I01.198.240.748.640', 'I01.19... | ['Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The case for medical marijuana in epilepsy. | Charlotte, a little girl with SCN1A-confirmed Dravet syndrome, was recently featured in a special that aired on CNN. Through exhaustive personal research and assistance from a Colorado-based medical marijuana group (Realm of Caring), Charlotte's mother started adjunctive therapy with a high concentration cannabidiol/Ä(... | ['Anticonvulsants', 'Cannabidiol', 'Epilepsies, Myoclonic', 'Epilepsy', 'Female', 'Humans', 'Infant', 'Medical Marijuana', 'Treatment Outcome'] | 24,854,149 | [['D27.505.954.427.080'], ['D02.455.849.090.100'], ['C10.228.140.490.375.130', 'C10.228.140.490.493.063'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D26.528'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Highly transparent sapphire micro-grating structures with large diffuse light scattering. | The highly transparent micro-grating structures (MGSs) of sapphire substrate with large diffuse light scattering were theoretically and experimentally studied. From the finite difference time domain simulation, it was found that the degree of diffuse light scattering is strongly dependent on the size of grating structu... | ['Algorithms', 'Aluminum Oxide', 'Computer Simulation', 'Electricity', 'Light', 'Materials Testing', 'Models, Theoretical', 'Optics and Photonics', 'Photons', 'Refractometry', 'Scattering, Radiation', 'Silicon Dioxide'] | 21,934,920 | [['G17.035', 'L01.224.050'], ['D01.056.050', 'D01.650.550.050'], ['L01.224.160'], ['G01.358.500.249'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.570'], ['E05.599'], ['H01.671.617', 'J01.293.688'], ['G01.249.705', 'G01.358.500.505.650.782', 'G01.590.540.782', 'G01.750.250.650.78... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Intraosseous lipoma: role and limitations of modern imaging techniques. | We report a case of intraosseous lipoma involving the ilium in a 37-year-old male. There were no clinical symptoms. Plain films suggested the diagnosis, which was confirmed by computed tomography and magnetic resonance imaging with fat-cancelling sequences. However, we were unable to rule out fatty involution of an old... | ['Adult', 'Bone Neoplasms', 'Diagnostic Imaging', 'Humans', 'Lipoma', 'Male'] | 7,600,069 | [['M01.060.116'], ['C04.588.149', 'C05.116.231'], ['E01.370.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.550.400']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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