Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Evolutionary divergence of the swim bladder nematode Anguillicola crassus after colonization of a novel host, Anguilla anguilla. | BACKGROUND: Anguillicola crassus, a swim bladder nematode naturally parasitizing the Japanese eel, was introduced about 30 years ago from East Asia into Europe where it colonized almost all populations of the European eel. We conducted a common garden experiment under a reciprocal transfer design infecting both Europea... | ['Air Sacs', 'Anguilla', 'Animals', 'Biological Evolution', 'Dracunculoidea', 'Fish Diseases', 'Genetic Fitness', 'Host Specificity', 'Reproduction'] | 23,566,258 | [['A13.048'], ['B01.050.150.900.493.338.282'], ['B01.050'], ['G05.045', 'G16.075'], ['B01.050.500.500.294.400.937.225.250'], ['C22.362'], ['G05.347'], ['G06.462.380', 'G16.527.200.380'], ['G08.686.784']] | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry. | Oxidation of lipoproteins is important for the initiation and propagation of the atherosclerotic lesion and may involve secondary oxidants derived from nitric oxide. Nitric oxide (NO) reacts at near diffusion limited rates with superoxide (O2-.) to form the strong oxidant, peroxynitrite (ONOO-). Nitration on the ortho ... | ['Cell Nucleus', 'Coronary Artery Disease', 'Coronary Vessels', 'Humans', 'Immunoenzyme Techniques', 'Macrophages', 'Middle Aged', 'Nitric Oxide', 'Oxidation-Reduction', 'Tyrosine'] | 8,192,861 | [['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['A07.015.114.269', 'A07.015.908.194'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of elective supraomohyoidal neck dissection in the treatment of early, node-negative oral squamous cell carcinoma (OSCC): a retrospective analysis of 122 cases. | The adequate treatment of the neck in early, clinically node-negative oral squamous cell carcinoma (OSCC) remains controversial. To assess whether elective supraomohyoid neck dissection is reasonable and efficient in early, locally circumscribed OSCC, the outcomes of treatment of 122 patients with an OSCC of clinical U... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Elective Surgical Procedures', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Logistic Models', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Mouth Neoplasms', 'Neck Dissection', 'Neck Muscles', 'Neoplasm Staging', 'Proportional Hazards... | 21,393,009 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E04.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tropomyosin as a regulator of the sliding movement of actin filaments. | We examined the capacity of tropomyosin molecules regulating the sliding movement of actin filaments on myosin molecules in the presence of ATP molecules to be hydrolyzed. For this objective, we prepared tropomyosin molecules modified to be a little bit stiffer compared to the intact ones by applying a fixed cross-link... | ['Actin Cytoskeleton', 'Actins', 'Adenosine Triphosphate', 'Animals', 'Cross-Linking Reagents', 'Electrophoresis, Polyacrylamide Gel', 'Models, Biological', 'Models, Chemical', 'Movement', 'Muscle Contraction', 'Myosins', 'Protein Isoforms', 'Rabbits', 'Time Factors', 'Tropomyosin'] | 17,184,900 | [['A11.284.430.214.190.750.050'], ['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D27.720.470.410.210'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.599.395'], ['E05.599.495'], ['G07.568', 'G11.427.410... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid Dissolution of BaSO4 | Insoluble BaSO4 scale is a costly and time-consuming problem in the petroleum industry. Clearance of BaSO4-impeded pipelines requires chelating agents that can efficiently bind Ba2+, the largest nonradioactive +2 metal ion. Due to the poor affinity of currently available chelating agents for Ba2+, however, the dissolut... | ['Barium', 'Barium Sulfate', 'Chelating Agents', 'Coordination Complexes', 'Crown Ethers', 'Ligands', 'Picolinic Acids', 'Solubility'] | 30,485,079 | [['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['D01.103.075', 'D01.875.800.800.850.075'], ['D27.505.519.914.500', 'D27.720.832.500'], ['D01.234', 'D02.257'], ['D02.355.291.308', 'D04.345.051.500', 'D04.345.241.308'], ['D27.720.470.480'], ['D03.066.707', 'D03.383.725.705'], ['G02.805']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiology and imaging of the subchondral bone in articular cartilage repair. | Articular cartilage and the subchondral bone act as a functional unit. Following trauma, osteochondritis dissecans, osteonecrosis or osteoarthritis, this intimate connection may become disrupted. Osteochondral defects-the type of defects that extend into the subchondral bone-account for about 5% of all articular cartil... | ['Arthroscopy', 'Bone Transplantation', 'Bone and Bones', 'Cartilage, Articular', 'Chondrocytes', 'Humans', 'Magnetic Resonance Imaging', 'Orthopedic Procedures', 'Osteoarthritis', 'Osteochondritis Dissecans', 'Osteonecrosis', 'Radionuclide Imaging', 'Tomography, X-Ray Computed'] | 20,148,327 | [['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A02.835.232', 'A10.165.265'], ['A02.165.407.150', 'A02.835.583.192'], ['A11.329.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E02.718', 'E04.555'], ['C05.550.114.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Contemporary lung cancer trends among U.S. women. | The age-standardized lung cancer incidence rate among women in the United States has decreased for each of the last 3 years for which data are available (1999-2001). We conducted this study to assess the stability and near-term sustainability of this decrease. We examined temporal trends in age-specific lung cancer inc... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Incidence', 'Lung Neoplasms', 'Middle Aged', 'SEER Program', 'Sex Factors', 'United States'] | 15,767,333 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520']... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Purification of two spectrin-binding proteins: biochemical and electron microscopic evidence for site-specific reassociation between spectrin and bands 2.1 and 4.1. | Two peripheral proteins of the human erythrocyte membrane that are capable of forming a stable complex with spectrin have been purified. The proteins, band 2.1 (Mr 210,000) and band 4.1 (Mr 82,000), are water soluble and exist as monomers in solution. Both exhibit strong, specific binding to purified spectrin molecules... | ['Binding Sites', 'Erythrocyte Membrane', 'Erythrocytes', 'Humans', 'Membrane Proteins', 'Microscopy, Electron', 'Molecular Weight', 'Protein Binding', 'Spectrin'] | 291,934 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk of hospitalization for survivors of childhood and adolescent cancer. | BACKGROUND: Childhood cancer survivors may be at increased risk of hospitalization because of cancer-related late effects.METHODS: Using data from population-based research resources in Utah, we identified childhood and adolescent cancer survivors who were diagnosed from 1973 to 2005 (N = 2,571). We selected a comparis... | ['Adolescent', 'Adult', 'Child', 'Female', 'Hospitalization', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Neoplasms', 'Survivors', 'Young Adult'] | 24,925,676 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['C04'], ['M01.860'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preschool behavioral problems in children prenatally exposed to antiepileptic drugs - a follow-up study. | We studied the association between maternal epilepsy, antiepileptic drug (AED) treatment, and behavioral problems in preschool children. In the Danish National Birth Cohort, we identified 4- to 5-year-old children whose mothers had epilepsy and received AED treatment (n=133) or not (n=304) during pregnancy and compared... | ['Adult', 'Anticonvulsants', 'Child', 'Child Behavior Disorders', 'Child, Preschool', 'Cohort Studies', 'Denmark', 'Epilepsy', 'Female', 'Humans', 'Male', 'Pregnancy', 'Pregnancy Complications', 'Prenatal Exposure Delayed Effects', 'Surveys and Questionnaires', 'Young Adult'] | 24,090,777 | [['M01.060.116'], ['D27.505.954.427.080'], ['M01.060.406'], ['F03.625.141'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['Z01.542.816.124'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C13.703'], ['C13.703.824.500'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Serotonergic modulation of odor input to the mammalian olfactory bulb. | Centrifugal serotonergic fibers innervate the olfactory bulb, but the importance of these projections for olfactory processing is unclear. We examined serotonergic modulation of sensory input to olfactory glomeruli using mice that express synaptopHluorin in olfactory receptor neurons (ORN). Odor-evoked synaptic input t... | ['Animals', 'Calcium Signaling', 'Cell Differentiation', 'Efferent Pathways', 'Glutamic Acid', 'Mice', 'Mice, Transgenic', 'Nerve Tissue Proteins', 'Olfactory Bulb', 'Olfactory Pathways', 'Olfactory Receptor Neurons', 'Raphe Nuclei', 'Receptor, Serotonin, 5-HT2C', 'Receptors, GABA-B', 'Sensory Receptor Cells', 'Seroton... | 19,430,472 | [['B01.050'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['G04.152'], ['A08.612.380'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['D12.776.631'], ['A08.186.21... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unusual fibularis (peroneus) muscle. | Routine dissection has identified a previously unrecorded fibularis (peroneus) muscle in a 74-year-old male cadaver. The anomalous fibularis muscle was found lying immediately antero-medial to the fibularis longus (FL) muscle of the left leg. The anomalous muscle arose from the muscle belly of the FL in the proximal 1/... | ['Aged', 'Anatomic Variation', 'Humans', 'Leg', 'Male', 'Muscle, Skeletal'] | 25,431,295 | [['M01.060.116.100'], ['G07.049', 'G16.117.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['A02.633.567', 'A10.690.552.500']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. | The nonsense-mediated mRNA decay (NMD) pathway is a highly conserved surveillance mechanism that is present in all eukaryotes. It prevents the synthesis of truncated proteins by selectively degrading mRNAs harbouring premature termination codons (PTCs). The core NMD effectors were originally identified in genetic scree... | ['Animals', 'Codon, Nonsense', 'Embryo, Nonmammalian', 'Embryonic Development', 'Humans', 'Neoplasm Proteins', 'RNA Helicases', 'RNA Stability', 'RNA, Messenger', 'Zebrafish', 'Zebrafish Proteins'] | 21,227,923 | [['B01.050'], ['D13.444.735.544.355.250.235', 'G05.360.335.355.250.235', 'G05.365.590.195'], ['A13.350', 'A16.331'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.624'], ['D08.811.913.696.445.735.720'], ['G02.111.780'], ['D13.444.735.544'], ['B01.050.150.900.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glycated hemoglobin and related factors in diabetic children and adolescents under 18 years of age: a Belgian experience. | OBJECTIVE: To determine, in an unselected population of diabetic children and adolescents < 18 years of age, which HbA1c levels can be achieved, and to examine the relationships with insulin regimen, insulin dose, sex, diabetes duration, BM1, and frequency of home blood glucose monitoring (HBGM) and outpatient clinic a... | ['Adolescent', 'Age Factors', 'Belgium', 'Blood Glucose', 'Blood Glucose Self-Monitoring', 'Body Mass Index', 'Child', 'Cohort Studies', 'Cross-Sectional Studies', 'Diabetes Mellitus', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Hypoglycemic Agents', 'Insulin', 'Male', 'Regression Analysis', 'Sex Factors', 'Time Fact... | 9,028,684 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['Z01.542.115'], ['D09.947.875.359.448.500'], ['E01.370.225.124.100.105', 'E01.370.374.100', 'E01.370.520.100', 'E02.900.950.500', 'E05.200.124.100.105'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.060.406... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial. | IMPORTANCE: Hospitalizations for heart failure (HHF) represent a major health burden, with high rates of early postdischarge rehospitalization and mortality.OBJECTIVE: To investigate whether aliskiren, a direct renin inhibitor, when added to standard therapy, would reduce the rate of cardiovascular (CV) death or HF reh... | ['Aged', 'Amides', 'Antihypertensive Agents', 'Double-Blind Method', 'Female', 'Follow-Up Studies', 'Fumarates', 'Heart Failure', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Patient Readmission', 'Renin', 'Stroke Volume', 'Treatment Outcome', 'Ventricular Dysfunction, Left'] | 23,478,743 | [['M01.060.116.100'], ['D02.065'], ['D27.505.954.411.162'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D02.241.081.337.302'], ['C14.280.434'], ['E02.760.400', 'N02.421.585.400'], ['B01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Diversity in junctional sequences associated with the common human V gamma 9 and V delta 2 gene segments in normal blood and lung compared with the limited diversity in a granulomatous disease. | The T cell receptor (TCR) junctional regions (N regions) of the common human V gamma 9 and V delta 2 gene segments were sequenced from the blood and lung of normal individuals (195 transcripts) and a group of individuals with sarcoidosis (220 transcripts), a granulomatous disease in which increased numbers of V gamma 9... | ['Adult', 'Antibodies, Monoclonal', 'Base Sequence', 'DNA', 'Female', 'Flow Cytometry', 'Gene Expression', 'Genetic Variation', 'Humans', 'Lung', 'Male', 'Molecular Sequence Data', 'Phenotype', 'RNA, Messenger', 'Receptors, Antigen, T-Cell', 'Receptors, Antigen, T-Cell, gamma-delta', 'Sarcoidosis', 'Sequence Homology, ... | 2,141,626 | [['M01.060.116'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Assessment of safety and protective value of a cell culture modified strain "C" vaccine of hog cholera/classical swine fever virus. | The protective value of a commercial strain "C" vaccine of classical swine fever (CSF) was tested in weaner pigs. Vaccinated animals were challenged intranasally with the virulent hog cholera virus (HCV) strain ALFORT/187 in groups of four pigs each at one to four weeks post vaccination, respectively. Non-vaccinated co... | ['Animals', 'Antibodies, Viral', 'Antigens, Viral', 'Classical Swine Fever', 'Classical Swine Fever Virus', 'Neutralization Tests', 'Swine', 'Vaccination', 'Viral Vaccines'] | 7,779,071 | [['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D23.050.327'], ['C01.925.782.350.675.200', 'C22.905.170'], ['B04.820.578.344.700.125'], ['E01.370.225.812.735.550', 'E05.200.812.735.550', 'E05.478.594.760.550'], ['B01.050.150.900.649.313.500.880'], ['E02.095... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Scalable fabrication of self-aligned graphene transistors and circuits on glass. | Graphene transistors are of considerable interest for radio frequency (rf) applications. High-frequency graphene transistors with the intrinsic cutoff frequency up to 300 GHz have been demonstrated. However, the graphene transistors reported to date only exhibit a limited extrinsic cutoff frequency up to about 10 GHz, ... | ['Equipment Design', 'Equipment Failure Analysis', 'Graphite', 'Molecular Conformation', 'Nanostructures', 'Transistors, Electronic'] | 21,648,419 | [['E05.320'], ['E05.325.192'], ['D01.268.150.300', 'D01.578.300'], ['G02.111.570.820'], ['J01.637.512'], ['E07.305.625.714']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Haplotype mapping of a major quantitative-trait locus for fetal hemoglobin production, on chromosome 6q23. | Fetal hemoglobin (Hb F) and fetal cell (FC) levels in adults show considerable variation and are influenced by several genetic variants; the major determinants appear to be unlinked to the beta-globin gene cluster. Recently, a trans-acting locus controlling Hb F and FC production has been mapped to chromosome 6q23 in a... | ['Chromosome Mapping', 'Chromosomes, Human, Pair 6', 'Female', 'Fetal Hemoglobin', 'Genetic Linkage', 'Genotype', 'Haplotypes', 'Humans', 'Male', 'Microsatellite Repeats', 'Pedigree', 'Quantitative Trait, Heritable'] | 9,585,587 | [['E05.393.183'], ['A11.284.187.520.300.325.330', 'G05.360.162.520.300.325.330'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['G05.348'], ['G05.380'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['E05.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Eukaryotic expression, purification of human IgECepsilon2-4 protein and its target fishing]. | Objective To construct eukaryotic expression vectors of human IgE heavy chain 2-4 region (IgECepsilon2-4) and purify the recombinant protein, and then capture its interacted proteins by surface plasmon resonance (SPR). Methods Three recombinant eukaryotic expression vectors of IgECepsilon2-4 containing different signal... | ['Blotting, Western', 'Chromatography, Affinity', 'Cloning, Molecular', 'Eukaryotic Cells', 'HEK293 Cells', 'Humans', 'Immunoglobulin E', 'Immunoglobulin epsilon-Chains', 'Recombinant Proteins', 'Transfection'] | 29,773,100 | [['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.196.181.400.170'], ['E05.393.220'], ['A11.450'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vascular conductance is reduced after menthol or cold application. | OBJECTIVE: To compare the effects of commercially sold menthol (3.5%) ointment and cold application on blood flow in the forearm.DESIGN: : Prospective counterbalanced design.SETTING: University research laboratory.PARTICIPANTS: Twelve (6 men and 6 women) college-aged students.INTERVENTIONS: Each participant had blood f... | ['Adult', 'Analysis of Variance', 'Antipruritics', 'Arm', 'Blood Flow Velocity', 'Blood Pressure', 'Brachial Artery', 'Cold Temperature', 'Female', 'Humans', 'Male', 'Menthol', 'Ointments', 'Prospective Studies', 'Statistics as Topic', 'Students', 'Universities', 'Young Adult'] | 20,818,196 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.954.444.075'], ['A01.378.800.075'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07.015.114.139'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Indust... | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition. | Recent clinical data indicate a synergistic therapeutic effect between trastuzumab and taxanes in neoadjuvantly treated HER2-positive breast cancer (BC) patients. In HER2+ BC experimental models and patients, we investigated whether this synergy depends on the ability of drug-induced stress to improve NK cell effective... | ['Animals', 'Antibodies, Blocking', 'Antibody-Dependent Cell Cytotoxicity', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Blotting, Western', 'Breast Neoplasms', 'Bridged-Ring Compounds', 'Cell Line, Tumor', 'Cells, Cultured', 'Docetaxel', 'Drug Synergism', 'Female', 'GPI-Linked Proteins',... | 26,595,802 | [['B01.050'], ['D12.776.124.486.485.114.143', 'D12.776.124.790.651.114.143', 'D12.776.377.715.548.114.143'], ['G12.287.070'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.180... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat. | We previously found that the opiate antagonist, naloxone, partially blocks stimulation-produced analgesia (SPA) elicited from ventral but not dorsal regions of the medial midbrain in rats. The present study compares the effects of n. raphe magnus (NRM) lesions on SPA from these same two midbrain areas. SPA thresholds w... | ['Animals', 'Brain Stem', 'Electric Stimulation', 'Ganglia, Spinal', 'Male', 'Mesencephalon', 'Naloxone', 'Nociceptors', 'Periaqueductal Gray', 'Raphe Nuclei', 'Rats', 'Rats, Inbred Strains', 'Receptors, Opioid', 'Sensory Thresholds', 'Synaptic Transmission'] | 6,301,628 | [['B01.050'], ['A08.186.211.132'], ['E05.723.402'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['A08.186.211.132.659'], ['D03.132.577.249.706', 'D03.605.497.750', 'D03.633.400.686.750', 'D04.615.723.795.706'], ['A08.675.650.915.875', 'A08.800.950.875', 'A11.671.650.915.875'], ['A08.186.211.132.6... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Crocin promotes non-rapid eye movement sleep in mice. | Crocus sativus L. (saffron) has been traditionally used for the treatment of insomnia and other diseases of the nervous systems. Two carotenoid pigments, crocin and crocetin, are the major components responsible for the various pharmacological activities of C. sativus L. In this study, we examined the sleep-promoting a... | ['Administration, Oral', 'Animals', 'Carotenoids', 'Crocus', 'Dose-Response Relationship, Drug', 'Electroencephalography', 'Injections, Intraperitoneal', 'Mice', 'Sleep Stages', 'Sleep, REM', 'Time'] | 22,038,919 | [['E02.319.267.100'], ['B01.050'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['B01.650.940.800.575.912.250.618.100.400.500'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.376.300', 'E01.370.405.245'], ['E02.319.267.530.490'], ['B01.050.150.900.649.313.992.635... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Removal of cyanobacteria and control of algal organic matter by simultaneous oxidation and coagulation - comparing the H2 | Cyanobacterial blooms in drinking water are worldwide concern. It is known that pre-oxidation enhanced coagulation can be more efficient at removing algae than traditional coagulation. However, its application is hindered by high oxidant/coagulant consumption and the resultant potential health risk, in the form of alga... | ['Cyanobacteria', 'Ferric Compounds', 'Ferrous Compounds', 'Hydrogen Peroxide', 'Microcystis', 'Oxidation-Reduction', 'Water Purification'] | 32,325,594 | [['B03.280', 'B03.440.475.100'], ['D01.490.100'], ['D01.490.200'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['B03.280.500', 'B03.440.475.100.500'], ['G02.700', 'G03.295.531'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Differential regulation of gonadotropin-releasing hormone neuron activity and membrane properties by acutely applied estradiol: dependence on dose and estrogen receptor subtype. | Gonadotropin-releasing hormone (GnRH) neurons are critical to controlling fertility. In vivo, estradiol can inhibit or stimulate GnRH release depending on concentration and physiological state. We examined rapid, nongenomic effects of estradiol. Whole-cell recordings were made of GnRH neurons in brain slices from ovari... | ['Animals', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Estradiol', 'Estrogen Receptor alpha', 'Estrogen Receptor beta', 'Female', 'Gonadotropin-Releasing Hormone', 'Membrane Potentials', 'Mice', 'Neurons', 'Protein Subunits', 'Receptors, Estrogen', 'Time Factors'] | 19,403,828 | [['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.283'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D12.776.826.750.350.174'], ['D12.776.826.750.350.262'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The spared nerve injury (SNI) model of induced mechanical allodynia in mice. | Peripheral neuropathic pain is a severe chronic pain condition which may result from trauma to sensory nerves in the peripheral nervous system. The spared nerve injury (SNI) model induces symptoms of neuropathic pain such as mechanical allodynia i.e. pain due to tactile stimuli that do not normally provoke a painful re... | ['Animals', 'Disease Models, Animal', 'Foot', 'Hyperalgesia', 'Mice', 'Mice, Inbred C57BL', 'Pain Measurement', 'Peripheral Nerve Injuries', 'Peripheral Nerves', 'Sciatic Nerve'] | 21,876,524 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A01.378.610.250'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['E01.370.600.550.324'], ['C10.668.829.712', 'C10.900.575... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Information needs of patients and visitors in a district general hospital. | A survey of the information needs of patients and visitors to a large District General Hospital was conducted during a one-month period in 1988 to identify sources of information used by patients and their visitors, whether these sources were perceived as adequate and what improvements were suggested. The findings indi... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Consumer Behavior', 'England', 'Female', 'Health Education', 'Hospitals, District', 'Humans', 'Male', 'Middle Aged', 'Patient Education as Topic', 'Surveys and Questionnaires', 'Visitors to Patients'] | 2,107,307 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.236'], ['Z01.542.363.300'], ['I02.233.332', 'N02.421.726.407'], ['N02.278.421.510.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I02.233.332.500', 'N02.421.726.407.680'], ['E05.318.308.980', 'N05.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
ABO-incompatible heart transplantation: analysis of the Pediatric Heart Transplant Study (PHTS) database. | BACKGROUND: ABO incompatible (ABOi) heart transplantation is an accepted approach to increasing organ availability for young patients. Previous studies have suggested that early survival for ABOi transplants is similar to ABO compatible (ABOc) transplants. We analyzed the Pediatric Heart Transplant Study (PHTS) databas... | ['ABO Blood-Group System', 'Blood Group Incompatibility', 'Databases, Factual', 'Follow-Up Studies', 'Graft Rejection', 'Heart Transplantation', 'Humans', 'Infant', 'Infant, Newborn', 'Infections', 'North America', 'Risk Factors', 'Survival Analysis', 'Treatment Outcome'] | 22,305,379 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['G09.188.114', 'G12.186'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G12.875.545.328'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['B01.050.150.900.64... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Influence of prototropic reactions on the absorption and fluorescence spectra of methyl p-dimethylaminobenzoate and its two ortho derivatives. | The influence of prototropic reactions on the spectral characteristics of methyl p-dimethylaminobenzoate (I) and its o-methoxy (II) and o-hydroxy (III) derivatives has been studied using steady-state spectroscopic technique and quantum-chemical calculations. This study concerns the solvent-induced shift of the absorpti... | ['4-Aminobenzoic Acid', 'Molecular Structure', 'Spectrometry, Fluorescence', 'Stereoisomerism', 'para-Aminobenzoates'] | 21,373,816 | [['D02.241.223.100.050.500.640', 'D02.455.426.559.389.127.020.937.640'], ['G02.111.570', 'G02.466'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['G02.607.445.682'], ['D02.241.223.100.050.500', 'D02.455.426.559.389.127.020.937']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The use of smart pumps for preventing medication errors. | The use of smart pumps can be helpful for preventing medication errors, especially with high-alert drugs in vulnerable critical care patient populations. A literature review was conducted to determine the evidence supporting the use of smart pumps for preventing medication errors. Cinahl and Medline databases from Janu... | ['Databases, Factual', 'Humans', 'Infusions, Intravenous', 'Medical Errors', 'Safety', 'Software', 'United States'] | 20,038,875 | [['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['N02.421.450'], ['N06.850.135.060.075'], ['L01.224.900'], ['Z01.107.567.875']] | ['Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Temperature dependence of the infinite dilution activity coefficient and Henry's law constant of polycyclic aromatic hydrocarbons in water. | The water solubility of 9,10-dihydroanthracene was experimentally determined between 278.12 and 313.17 K. Determinations were carried out by an experimental procedure developed in our laboratory, which is a modification of the dynamic coupled column liquid chromatographic technique. The uncertainty of the experimental ... | ['Anthracenes', 'Chromatography, Liquid', 'Entropy', 'Phase Transition', 'Polycyclic Aromatic Hydrocarbons', 'Pyrenes', 'Solubility', 'Temperature', 'Thermodynamics', 'Water'] | 15,212,897 | [['D02.455.426.559.847.117', 'D04.615.117'], ['E05.196.181.400'], ['G01.906.345'], ['G01.645', 'G02.734'], ['D02.455.426.559.847', 'D04.615'], ['D02.455.426.559.847.799', 'D04.615.799'], ['G02.805'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.9... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Predicting childhood obesity prevention behaviors using social cognitive theory among upper elementary African-American children. | Childhood obesity is a major public health problem in the African-American community. Commonly suggested public health strategies to reduce childhood obesity are limiting television viewing, encouraging daily moderately intense physical activity of at least 60 minutes per day, increasing fruit and vegetable intake to f... | ['African Americans', 'Cognition', 'Cross-Sectional Studies', 'Diet', 'Female', 'Health Behavior', 'Humans', 'Male', 'Motor Activity', 'Obesity', 'Primary Prevention', 'Self Efficacy', 'Television', 'United States', 'Water'] | 24,928,610 | [['M01.686.508.100.100', 'M01.686.754.100'], ['F02.463.188'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.240'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Geographicals [Z]', 'Chemicals and Dru... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
Regression of lung size in adults with growth hormone deficiency. | Pulmonary function was investigated in eight patients with hypopituitarism in order to determine if the lung is affected by the generalized visceral atrophy of hypopituitarism; six patients with acromegaly and trophic hormone deficiencies were studied for comparison. The patients with hypopituitarism, including one wit... | ['Acromegaly', 'Adult', 'Aged', 'Female', 'Growth Hormone', 'Humans', 'Hypopituitarism', 'Lung', 'Lung Volume Measurements', 'Male', 'Middle Aged'] | 7,465,765 | [['C05.116.132.082', 'C10.228.140.617.738.250.100', 'C19.700.355.179'], ['M01.060.116'], ['M01.060.116.100'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.617.738.300', 'C19.700.482'], ['A04.411'], ['E01.370.386.700.485'], ['M01.060.116.630']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
High-pressure injection injuries of the hand. | The majority of high-pressure injection injuries can produce serious damage to the hand. Nevertheless, the injury may follow a relatively benign course if the injected substance possesses a less harmful nature. Treatment for these injuries requires immediate and aggressive surgery in most circumstances, but conservativ... | ['Accidents, Occupational', 'Adult', 'Hand Injuries', 'Humans', 'Injections', 'Male', 'Oils', 'Paint', 'Pressure', 'Radiography', 'Water'] | 1,986,114 | [['N06.850.135.240'], ['M01.060.116'], ['C26.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530'], ['D10.627'], ['J01.637.597'], ['G01.374.715'], ['E01.370.350.700'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Immunohistochemical characterization of specific inflammatory tissue reactions following embolization with four different spherical agents in the minipig kidney model. | PURPOSE: To evaluate the immunohistochemical inflammatory reaction after porcine renal embolization with the new spherical embolic agent Embozene and to compare it with other spherical embolic agents.MATERIALS AND METHODS: After superselective porcine renal embolization (40 pigs) with different sizes of embolic agents ... | ['Acrylic Resins', 'Animals', 'Disease Models, Animal', 'Gelatin', 'Hemostatics', 'Humans', 'Kidney', 'Nephritis', 'Swine', 'Swine, Miniature', 'Uterine Artery Embolization'] | 19,555,888 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.860.476'], ['D27.505.954.502.270.463'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419.570', 'C13.351.968.419.570'], ['B01.050.150.900.64... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. | Acute myeloid leukemia 1 (AML1) belongs to a family of DNA-binding proteins highly conserved through evolution. AML1 regulates the expression of several hematopoietic genes and is essential for murine fetal liver hematopoiesis. We report here that the histone methyltransferase SUV39H1, a mammalian ortholog of the Droso... | ['3T3 Cells', 'Animals', 'Core Binding Factor Alpha 2 Subunit', 'DNA', 'DNA-Binding Proteins', 'Methylation', 'Methyltransferases', 'Mice', 'Promoter Regions, Genetic', 'Protein Binding', 'Proto-Oncogene Proteins', 'Receptor, Macrophage Colony-Stimulating Factor', 'Repressor Proteins', 'Transcription Factors'] | 12,917,624 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['D12.776.930.155.200.200'], ['D13.444.308'], ['D12.776.260'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538'], ['D08.811.913.555.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.75... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The influence of protein-calorie malnutrition on quality of life in nursing homes. | BACKGROUND: Up to 85% of the older adults living in our nation's nursing homes suffer from protein-calorie malnutrition (PCM). Early identification and treatment of PCM can reduce or prevent hospital stays, reduce complications, and decrease mortality. We describe the influence of PCM on quality of life in nursing home... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Body Mass Index', 'Body Weight', 'Female', 'Geriatric Assessment', 'Homes for the Aged', 'Humans', 'Incidence', 'Male', 'Nursing Homes', 'Nutritional Requirements', 'Nutritional Status', 'Protein-Energy Malnutrition', 'Quality of Life', 'Risk Assessment', 'Si... | 12,586,854 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Low dose streptozotocin induced diabetes in mice. Metabolic, light microscopical, histochemical, immunofluorescence microscopical, electron microscopical and morphometrical findings. | The experimental animal model of human insulin-dependent diabetes mellitus (IDDM, type I diabetes), which was for the first time described by Like and Rossini (1976) for Charles River CD-1 mice and produced by the application of multiple subdiabetogenic streptozotocin (SZ) doses, has been reproduced in the mouse strain... | ['Animals', 'Blood Glucose', 'Body Weight', 'Diabetes Mellitus, Experimental', 'Fluorescent Antibody Technique', 'Histocytochemistry', 'Islets of Langerhans', 'Lymphocytes', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Microscopy, Electron', 'Pancreas', 'Streptozocin'] | 3,157,595 | [['B01.050'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.75... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of Vitamin D on Joint Replacement Outcomes. | Vitamin D is a steroid hormone that affects not only bone metabolism and strength but also a variety of musculoskeletal health and surgical outcomes that are relevant to orthopaedic medicine. Risk factors for vitamin D deficiency include sex, age, skin pigmentation, obesity, and preexisting conditions such as nephritic... | ['Arthroplasty, Replacement', 'Humans', 'Joint Diseases', 'Musculoskeletal System', 'Patient Care Planning', 'Patient Outcome Assessment', 'Postoperative Complications', 'Preoperative Care', 'Risk Factors', 'Vitamin D', 'Vitamin D Deficiency', 'Vitamins'] | 27,049,217 | [['E04.555.110.110', 'E04.650.110', 'E04.680.101.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550'], ['A02'], ['N04.590.233.624'], ['N04.761.559.590.399', 'N05.715.360.575.575.399'], ['C23.550.767'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells. | Colorectal cancer (CRC) is one of the leading causes of cancer mortality and 5-Fluorouracil (5-FU) is the most common chemotherapy agent of CRC. A high level of X-ray repair cross complementing group 1 (XRCC1) in cancer cells has been associated with the drug resistance occurrence. Moreover, the activation of adenosine... | ['Aminoimidazole Carboxamide', 'Antineoplastic Agents', 'Apoptosis', 'Cell Proliferation', 'Cell Survival', 'Colorectal Neoplasms', 'Drug Resistance, Neoplasm', 'Drug Synergism', 'Drug Therapy, Combination', 'Fluorouracil', 'HCT116 Cells', 'Humans', 'Protein Kinases', 'Receptors, CXCR4', 'Ribonucleotides', 'X-ray Repai... | 29,117,108 | [['D03.383.129.308.030'], ['D27.505.954.248'], ['G04.146.954.035'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G07.690.773.984.395'], ['G07.690.773.968.477'], ['E02... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions. | Members of the three-zinc-finger family of transcription factors play an important role in determining basal transcription. We have cloned mouse BTEB3 (mBTEB3), a new member of the basic transcription element binding protein (BTEB) family, which is expressed in a wide variety of tissues. mBTEB3 activates transcription ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Cycle Proteins', 'Cloning, Molecular', 'DNA-Binding Proteins', 'GC Rich Sequence', 'Gene Expression Regulation, Developmental', 'Kruppel-Like Transcription Factors', 'Mice', 'Microfilament Proteins', 'Molecular Sequence Data', 'Muscle Proteins', 'Promoter Region... | 10,642,511 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.167'], ['E05.393.220'], ['D12.776.260'], ['G02.111.570.080.380', 'G05.360.080.380'], ['G05.308.310'], ['D12.776.260.522', 'D12.776.930.375'], ['B01.050.150.900.649.313.992.635.505.500'], ['D05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa | â-Lactam antibiotics inhibit cell-wall transpeptidases, preventing the peptidoglycan, the major constituent of the bacterial cell wall, from cross-linking. This causes accumulation of long non-cross-linked strands of peptidoglycan, which leads to bacterial death. Pseudomonas aeruginosa, a nefarious bacterial pathogen, ... | ['Bacterial Proteins', 'Crystallography, X-Ray', 'Glycoside Hydrolases', 'Peptidoglycan', 'Protein Domains', 'Pseudomonas aeruginosa', 'Structure-Activity Relationship'] | 29,632,171 | [['D12.776.097'], ['E05.196.309.742.225'], ['D08.811.277.450'], ['D09.400.420.700', 'D09.698.718.594', 'D12.644.233.594', 'D12.776.395.560.800', 'D23.050.161.616.594'], ['G02.111.570.820.709.275.750', 'G02.111.570.820.709.610.500'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['G02.111.830', 'G07.690.77... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitation of human choriocarcinoma spheroid attachment to uterine epithelial cell monolayers. | Adhesive interactions of trophoblast cells with endometrium are essential for embryo implantation in the uterus. Choriocarcinoma cells, the malignant counterpart of trophoblast, show pronounced invasiveness and are of interest for model studies. We describe here an in vitro model system for the study of adhesion of hum... | ['Cell Adhesion', 'Cell Differentiation', 'Cell Line', 'Choriocarcinoma', 'Embryo Implantation', 'Endometrium', 'Epithelial Cells', 'Female', 'Humans', 'Kinetics', 'Models, Biological', 'Trophoblasts', 'Tumor Cells, Cultured'] | 8,331,030 | [['G04.022'], ['G04.152'], ['A11.251.210'], ['C04.557.465.955.207', 'C04.557.470.200.025.455', 'C04.850.908.208', 'C13.703.720.949.208'], ['G08.686.784.170.104.500'], ['A05.360.319.679.490'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['A11.382.992', '... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Poliovirus retention in 75-cm soil cores after sewage and rainwater application. | The adsorption rate of a guanidine-resistant strain of poliovirus LSc 2ab was measured in Long Island soils with in situ field cores (10.1 by 75 cm). The test virus was chosen because it exhibited soil adsorption and elution characteristics of a number of non-polioviruses. After the inoculation of cores with seeded sew... | ['Adsorption', 'Poliovirus', 'Rain', 'Sewage', 'Soil Microbiology', 'Water'] | 6,257,159 | [['G01.030', 'G02.020'], ['B04.820.578.750.284.184.500'], ['G16.500.175.859', 'G16.500.275.063.725.395', 'G16.500.750.775.450', 'N06.230.300.100.725.450', 'N06.230.520'], ['D20.944.932.500'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of Fanbaicao (Herba Potentillae Discoloris) oil on the expression
of p21 and CDK4 in HepG2 cells. | OBJECTIVE: To research the anti-cancer mechanism
of the Traditional Chinese Medicine Fanbaicao
(Herba Potentillae Discoloris) oil in the human hepatoma
cell line HepG2.METHODS: Gas chromatography was used to analyze
the components of Fanbaicao (Herba Potentillae
Discoloris). We tested the inhibitory effect of Fanbaicao... | ['Apoptosis', 'Cell Cycle', 'Cell Proliferation', 'Cyclin-Dependent Kinase 4', 'Cyclin-Dependent Kinase Inhibitor p21', 'Drugs, Chinese Herbal', 'Hep G2 Cells', 'Humans', 'Liver Neoplasms', 'Potentilla'] | 28,459,517 | [['G04.146.954.035'], ['G04.144'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.913.696.620.682.700.646.500.875', 'D12.644.360.250.451', 'D12.776.167.200.451', 'D12.776.476.250.451'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.66... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Remission of Epstein-Barr virus-positive post-transplant lymphoproliferative disorder by conversion to everolimus in a kidney transplant recipient. | Post-transplant lymphoproliferative disorder (PTLD) is a fatal complication of transplantation. There is no clear consensus on the treatment of PTLD. In most cases, the pathogenetic mechanism of PTLD involves the Epstein-Barr virus (EBV). We report the case of an elderly kidney transplant recipient who developed EBV-po... | ['Aged', 'Epstein-Barr Virus Infections', 'Everolimus', 'Herpesvirus 4, Human', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Lymphoproliferative Disorders', 'Male', 'Postoperative Complications', 'Remission Induction', 'Transplant Recipients'] | 31,102,475 | [['M01.060.116.100'], ['C01.925.256.466.313', 'C01.925.928.313'], ['D02.540.505.760.500'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['C15.604.515', '... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Overexpression of CXCL1 and its receptor CXCR2 promote tumor invasion in gastric cancer. | BACKGROUND: The chemokine (C-X-C motif) ligand 1 (CXCL1) and its receptor CXCR2 are associated with metastasis potential. Our studies were designed to clarify the CXCL1 and CXCR2 expression patterns and to explore their potential role in gastric cancer.DESIGN: The expression of CXCL1 was determined in primary gastric c... | ['Aged', 'Cell Movement', 'Chemokine CXCL1', 'Disease Progression', 'Female', 'Humans', 'Immunohistochemistry', 'Interleukin-8', 'Male', 'Matrix Metalloproteinase 2', 'Middle Aged', 'Neoplasm Invasiveness', 'Real-Time Polymerase Chain Reaction', 'Receptors, Interleukin-8B', 'Stomach Neoplasms', 'Up-Regulation'] | 21,343,381 | [['M01.060.116.100'], ['G04.198', 'G07.568.500.180'], ['D12.644.276.374.200.120.050', 'D12.776.467.374.200.120.050', 'D12.776.624.664.700.049', 'D23.125.300.120.050', 'D23.469.200.120.050', 'D23.529.374.200.120.050'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of high di(2-ethylhexyl) phthalate (DEHP) exposure due to tainted food intake on pre-pubertal growth characteristics in a Taiwanese population. | On May 23, 2011, a major scandal involving the illegal use of phthalates as clouding agents in food products was reported. Specifically, di(2-ethylhexyl) phthalate (DEHP) was purposefully added to foods as a substitute emulsifier. The purpose of this study was to examine the effects of DEHP exposure on the growth chara... | ['Anthropometry', 'Body Height', 'Body Weight', 'Bone Development', 'Child', 'Diethylhexyl Phthalate', 'Environmental Exposure', 'Environmental Pollutants', 'Female', 'Food Contamination', 'Humans', 'Male', 'Taiwan'] | 27,209,343 | [['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.345.500.325.377.625.050.500', 'G11.427.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Qualitative study of mechanical parameters of conventional diagnostic X-ray machines in Mizoram. | The present study examined the mechanical attributes of 135 conventional diagnostic X-ray machines in Mizoram, India. The purpose of studying the X-ray mechanical parameters, such as congruency, perpendicularity of the central beam, and half-value layer, was to improve the quality of the diagnostic image and reduce the... | ['Equipment Design', 'India', 'Light', 'Mechanical Phenomena', 'Radiography'] | 29,777,432 | [['E05.320'], ['Z01.252.245.393'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G01.374'], ['E01.370.350.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Longitudinal investigation of exposure to arsenic, cadmium, and lead in drinking water. | Arsenic, cadmium, and lead have been associated with various forms of cancer, nephrotoxicity, central nervous system effects, and cardiovascular disease in humans. Drinking water is a well-recognized pathway of exposure to these metals. To improve understanding of the temporal dimension of exposure to As, Cd, and Pb in... | ['Arsenic', 'Cadmium', 'Environmental Exposure', 'Humans', 'Lead', 'Longitudinal Studies', 'Maryland', 'Water Pollutants, Chemical', 'Water Supply'] | 10,964,793 | [['D01.268.513.249'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.435', 'D01.552.544.435'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['Z01.107.567.875.075.418', 'Z01.107.5... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Activation of androgen receptor function by a novel nuclear protein kinase. | Androgen receptor (AR) belongs to the nuclear receptor superfamily and mediates the biological actions of male sex steroids. In this work, we have characterized a novel 130-kDa Ser/Thr protein kinase ANPK that interacts with the zinc finger region of AR in vivo and in vitro. The catalytic kinase domain of ANPK shares c... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Binding Sites', 'CHO Cells', 'COS Cells', 'Cell Line', 'Cell Nucleus', 'Cricetinae', 'DNA, Complementary', 'Gene Expression', 'Humans', 'Male', 'Molecular Sequence Data', 'Nuclear Proteins', 'PC12 Cells', 'Protein-Serine-Threonine Kinases', 'Rats', 'Receptors, Androg... | 9,725,910 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['A11.251.210.200', 'A11.436.155'], ['A11.251.210.172.500', 'A11.329.228.220'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.649.313.992.635... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Geographical variations in hypertension prevalence, awareness, treatment and control in China: findings from a nationwide and provincially representative survey. | OBJECTIVES: Hypertension has been the most important risk factor for disease burden in China. We aimed to conduct the first national spatial analysis of hypertension status, awareness, treatment and control in China.METHODS: Choropleth maps were used to examine the spatial patterning of hypertension, awareness, treatme... | ['Adult', 'Aged', 'Body Weight', 'China', 'Female', 'Geography, Medical', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Prevalence', 'Risk Factors', 'Surveys and Questionnaires', 'Urbanization'] | 29,210,864 | [['M01.060.116'], ['M01.060.116.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['Z01.252.474.164'], ['H01.277.500.097', 'H02.403.352'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], [... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenome... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Monounsaturated diet lowers LDL oxidisability in type IIb and type IV dyslipidemia without affecting coenzyme Q10 and vitamin E contents. | The purpose of the present study was to evaluate the effects of MUFA vs PUFA enriched diets on the plasma and LDL lipid profile and antioxidant contents in mild hypercholesterolemic and triglyceridemic subjects. The study was divided in two consecutive diet periods. Two groups of 11 dyslipidemic patients each (type IIb... | ['Cholesterol', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Coenzymes', 'Dietary Fats, Unsaturated', 'Fatty Acids, Monounsaturated', 'Fatty Acids, Unsaturated', 'Humans', 'Hypercholesterolemia', 'Hypertriglyceridemia', 'Olive Oil', 'Plant Oils', 'Soybean Oil', 'Triglycerides', 'Ubiquinone', 'Vitamin E'] | 10,416,048 | [['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['D08.211'], ['D10.212.302.380', 'G07.203.300.37... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Expression and localization of follicle-stimulating hormone receptor in the yak uterus during different stages of the oestrous cycle. | Morphological changes of the uterus and alterations in its secretory activity under the influence of steroid hormones been well documented. The oestrous cycle is also associated with significant changes in plasma follicle-stimulating hormone (FSH), whose effects are mediated through its receptor (FSHR). Reports showed ... | ['Animals', 'Cattle', 'Estrous Cycle', 'Female', 'Gene Expression', 'Receptors, FSH', 'Uterus'] | 30,120,840 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G08.686.195'], ['G05.297'], ['D12.776.543.750.695.250', 'D12.776.543.750.720.600.370', 'D12.776.543.750.750.555.370', 'D12.776.543.750.750.660.350.300'], ['A05.360.319.679']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) of rapid-acting insulin analogues and detemir in type 1 diabetic (T1D) pregnant women. | OBJECTIVE: To compare glycemic control, maternal-neonatal outcomes and fetal fat body mass growth of type 1 diabetic pregnant women treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI) with the long-acting insulin analogue detemir as basal insulin.METHODS: Retrospective study ... | ['Adult', 'Cost-Benefit Analysis', 'Diabetes Mellitus, Type 1', 'Female', 'Humans', 'Hypoglycemic Agents', 'Infusions, Subcutaneous', 'Injections, Subcutaneous', 'Insulin Detemir', 'Insulin Infusion Systems', 'Pregnancy', 'Retrospective Studies'] | 24,724,804 | [['M01.060.116'], ['N03.219.151.125'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['E02.319.267.510.795'], ['E02.319.267.530.620'], ['D06.472.699.587.200.300.050', 'D12.644.548.586.200.300.050'], ['E02.319.300.508', 'E07.505.508', 'E07.85... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Some observations on the determination of cortisol in human plasma by radioimmunoassay using antisera against cortisol-3-BSA. | Antisera were obtained from rabbits immunised against cortisol-3-BSA with a view to examining their application in a radioimmunoassay of the steroid. One such antiserum was studied in detail; cross-reactivity with other C21 steroids normally present in human plasma was negligible and it proved possible to establish a r... | ['Addison Disease', 'Adult', 'Animals', 'Cattle', 'Cross Reactions', 'Humans', 'Hydrocortisone', 'Methods', 'Protein Binding', 'Radioimmunoassay', 'Serum Albumin, Bovine'] | 1,239,101 | [['C19.053.500.263', 'C20.111.163'], ['M01.060.116'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G12.122.281'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['E05.581'], ['G02.111.679', 'G03.808'], ['E01.370.384.700'... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Preoperative fluid bolus and reduction of postoperative nausea and vomiting in patients undergoing laparoscopic gynecologic surgery. | We conducted a randomized clinical trial of patients undergoing laparoscopic gynecologic surgery to determine the effect of a calculated preoperative fluid bolus on postoperative nausea and vomiting (PONV). For the study, 46 women were randomly assigned to an experimental group, group 1, or a control group, group 2. Gr... | ['Adolescent', 'Adult', 'Aged', 'Double-Blind Method', 'Female', 'Fluid Therapy', 'Gynecologic Surgical Procedures', 'Humans', 'Laparoscopy', 'Middle Aged', 'Postoperative Nausea and Vomiting', 'Preoperative Care', 'Prospective Studies'] | 19,388,505 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.360'], ['E04.950.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['C23.550.767.859', 'C23.888.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Egocentric social network analysis of pathological gambling. | AIMS: To apply social network analysis (SNA) to investigate whether frequency and severity of gambling problems were associated with different network characteristics among friends, family and co-workers is an innovative way to look at relationships among individuals; the current study was the first, to our knowledge, ... | ['Adult', 'Alcohol Drinking', 'Behavior, Addictive', 'Ego', 'Family', 'Female', 'Friends', 'Gambling', 'Humans', 'Male', 'Sexual Partners', 'Smoking', 'Social Support'] | 23,072,641 | [['M01.060.116'], ['F01.145.317.269'], ['F01.145.527.100.120'], ['F01.752.747.189', 'F02.739.794.206'], ['F01.829.263', 'I01.880.853.150'], ['M01.252'], ['F01.145.722.408', 'F03.250.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.778'], ['F01.145.805'], ['I01.880.853.500.600']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Selecting and evaluating decision-making strategies in the intensive care unit: A systematic review. | PURPOSE: Many patients in the Intensive Care Unit (ICU) die after a decision to withhold or withdraw treatment. To ensure that for each patient the appropriate decision is taken, a careful decision-making process is required. This review identifies strategies that can be used to optimize the decision-making process for... | ['Communication', 'Critical Illness', 'Decision Making', 'Decision Support Techniques', 'Humans', 'Intensive Care Units', 'Life Support Care'] | 30,738,286 | [['F01.145.209', 'L01.143'], ['C23.550.291.625'], ['F02.463.785.373'], ['E05.245', 'L01.313.500.750.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['E02.760.440', 'N02.421.585.440']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A paradoxical effect of an antiestrogen, CI-628, on implantation in the mouse. | Some triphenylethylene compounds (TPE), commonly known as antiestrogens, have been reported to interfere with pregnancy. This effect of these TPE compounds was attributed to their antagonistic effects to estrogen in the uterus and/or the embryo. Paradoxically, recent evidence suggests that several TPE compounds act as ... | ['Animals', 'Drug Administration Schedule', 'Embryo Implantation', 'Embryonic Development', 'Female', 'Mice', 'Mice, Inbred Strains', 'Nitromifene', 'Pregnancy', 'Progesterone', 'Pyrrolidines'] | 3,054,903 | [['B01.050'], ['E02.319.283'], ['G08.686.784.170.104.500'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['D03.383.773.610'], ['G08.686.784.769'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lactate transport in macrophages. | Macrophages perform phagocytic and effector activities in a number of different tissues. The environment of the inflammatory foci in which they function is often acidic and contains an abundance of lactate. We characterized the ability of thioglycollate-elicited mouse peritoneal macrophages to accumulate lactate from t... | ['Adenosine Triphosphate', 'Animals', 'Biological Transport', 'Cells, Cultured', 'Energy Metabolism', 'Hydrogen-Ion Concentration', 'Lactates', 'Lactic Acid', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'Monensin', 'Nigericin', 'Peritoneal Cavity', 'Sodium', 'Stereoisomerism'] | 8,436,827 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['G03.143'], ['A11.251'], ['G03.295'], ['G02.300'], ['D02.241.511.459'], ['D02.241.511.459.450'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.900.649.313.992.635.505.500'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
History of the membrane (pump) theory of the living cell from its beginning in mid-19th century to its disproof 45 years ago--though still taught worldwide today as established truth. | The concept that the basic unit of all life, the cell, is a membrane-enclosed soup of (free) water, (free) K+ (and native) proteins is called the membrane theory. A careful examination of past records shows that this theory has no author in the true sense of the word. Rather, it grew mostly out of some mistaken ideas m... | ['Animals', 'Cell Membrane', 'Cell Nucleus', 'Cell Survival', 'Cytoplasm', 'History, 18th Century', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Ion Channels', 'Models, Biological', 'Osmosis'] | 18,613,639 | [['B01.050'], ['A11.284.149'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.346'], ['A11.284.430.214'], ['K01.400.504.875'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['E05.599.395'], ['G... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Humanities [K]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Pain and disease as a transformation. An analysis from phenomenology and narration]. | Pain and disease are life experiences difficult to be understood due to different reasons: they both fall under subjective limits; the sufferer feels imprisoned in his own pain and perceives a radical rupture within himself, and the sufferer feels he is alone to himself, unable to communicate. All these reasons explain... | ['Humans', 'Identity Crisis', 'Loneliness', 'Narration', 'Pain', 'Time'] | 30,380,898 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.747.423'], ['F01.470.713', 'I01.880.853.748.435'], ['E05.318.308.502', 'F01.145.209.459', 'L01.399.250.660', 'N05.715.360.300.480', 'N06.850.520.308.502'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['G01.910']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
A matched-control evaluation of an antifungal bundle in the intensive care unit at a university teaching hospital. | BACKGROUND: Antimicrobial use bundles are becoming a common means of implementing antimicrobial stewardship initiatives in the hospital setting. Although the utility of these bundles has been described for many disease states, their adoption for antifungal therapy management is largely unknown.OBJECTIVE: Our objective ... | ['Adult', 'Antifungal Agents', 'Caspofungin', 'Echinocandins', 'Female', 'Hospitals, Teaching', 'Hospitals, University', 'Humans', 'Intensive Care Units', 'Lipopeptides', 'Male', 'Middle Aged'] | 23,100,183 | [['M01.060.116'], ['D27.505.954.122.136'], ['D10.477.250', 'D12.644.365.250', 'D12.644.641.311.500'], ['D12.644.641.311'], ['N02.278.020.300', 'N02.278.421.639'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['D10.477', 'D12.644.365'], ['M01.060.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Effect of dihydropyrrol and maleimide derivatives on the state of the liver and colon in normal rats and those with colorectal carcinogenesis induced by dimethylhydrazine]. | No liver and colon alterations in rats, caused by cytostatic compounds 5-amino-4-(1,3-benzothyazol-2-yl)-1-(3-methoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one (D1) and 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) when administered over a long time were found, as evidenced by the histopathological data ... | ['1,2-Dimethylhydrazine', "8-Hydroxy-2'-Deoxyguanosine", 'Alkaline Phosphatase', 'Animals', 'Antineoplastic Agents', 'Cell Nucleus', 'Cell Transformation, Neoplastic', 'Colon', 'Colonic Neoplasms', 'DNA Damage', 'Deoxyguanosine', 'Hepatocytes', 'Intestinal Mucosa', 'L-Lactate Dehydrogenase', 'Liver', 'Male', 'Maleimide... | 23,937,051 | [['D02.442.600.400.200'], ['D03.633.100.759.590.454.240.500', 'D13.570.230.360.500', 'D13.570.583.454.240.500'], ['D08.811.277.352.650.035'], ['B01.050'], ['D27.505.954.248'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chronic stress induced changes in LH secretion: the contribution of anorexia associated to stress. | The effects of chronic intermittent immobilization (IMO) on serum LH levels of adult male rats were studied. Chronic IMO (2 h daily for 13 days) did not alter basal LH levels, but abolished the LH response to acute stressors (IMO and tailshock). The inhibition of LH caused by acute exposure to IMO for 4 or 18 h was sim... | ['Analysis of Variance', 'Animals', 'Anorexia', 'Immobilization', 'Luteinizing Hormone', 'Male', 'Random Allocation', 'Rats', 'Rats, Sprague-Dawley', 'Stress, Physiological'] | 8,450,711 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['C23.888.821.108'], ['E05.472'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['B01.050.150.900.649.313.99... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase. | CD44 is a receptor for hyaluronan and mediates signaling that regulates complex cell behavior including cancer cell migration and invasion. Shedding of the extracellular portion of CD44 is the last step in the regulation of the molecule-releasing interaction between the ligand and cell. However, highly glycosylated for... | ['ADAM Proteins', 'ADAM10 Protein', 'Amino Acid Sequence', 'Amyloid Precursor Protein Secretases', 'Antibody Specificity', 'Cell Line, Tumor', 'Humans', 'Hyaluronan Receptors', 'Matrix Metalloproteinases, Membrane-Associated', 'Melanoma', 'Membrane Proteins', 'Metalloendopeptidases', 'Molecular Sequence Data', 'Peptide... | 14,871,815 | [['D08.811.277.656.675.374.102', 'D09.400.430.500', 'D12.776.395.033'], ['D08.811.277.656.675.374.102.250', 'D09.400.430.500.250', 'D12.776.395.033.250'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D08.811.277.656.300.032'], ['G12.100'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae. | Caveolae and its structural protein caveolin-1 (Cav-1) are abundant in vascular endothelial cells (ECs). We examined whether caveolae are involved in monocyte adhesion to ECs responding to a synergy of hypercholesterolemia and inflammation. Treating human umbilical vein ECs with cholesterol enhanced endotoxin lipopolys... | ['Animals', 'Apolipoproteins E', 'Biological Transport', 'Cattle', 'Caveolae', 'Caveolin 1', 'Cell Adhesion', 'Cholesterol', 'Endothelium, Vascular', 'Gene Expression Regulation', 'Humans', 'Hypercholesterolemia', 'Inflammation', 'Intercellular Adhesion Molecule-1', 'Lipopolysaccharides', 'Mice', 'Mice, Knockout', 'Mon... | 20,382,259 | [['B01.050'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['G03.143'], ['B01.050.150.900.649.313.500.380.271'], ['A11.284.149.165.175.160', 'A11.284.149.165.570.160', 'A11.284.430.214.190.875.190.880.180.160'], ['D12.644.360.024.264', 'D12.776.157.057.010', 'D12.776.476.024.280', 'D12.776.543.990... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
["Pro Ana": Psychodynamic References for Anorexia Nervosa]. | "Pro Ana": Psychodynamic References for Anorexia Nervosa The internet-based phenomenon "Pro Ana" refers to the eating disorder anorexia nervosa in a positive way. To understand what the phenomenon "Pro Ana" represents, the websites are used as a starting point of the current analysis. Based on these results, similariti... | ['Anorexia Nervosa', 'Blogging', 'Body Image', 'Countertransference', 'Feeding and Eating Disorders', 'Female', 'Humans', 'Internet', 'Motivation', 'Narcissism', 'Patient Acceptance of Health Care', 'Psychoanalytic Theory', 'Self Concept', 'Social Networking', 'Social Support', 'Social Values', 'Therapy, Computer-Assis... | 28,142,631 | [['F03.400.125'], ['L01.143.140', 'L01.178.148', 'L01.559.423.906.296'], ['F01.752.747.792.110', 'F02.463.593.112'], ['F04.754.720.864.363'], ['F03.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['F01.658', 'F01.752.543.500.750'], ['F02.739.794.582'], ['F01.100.150.750.500', 'F01.145.4... | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
[A case of gastric cancer with DIC caused by multiple bone metastases treated with TS-1]. | A 71-year-old woman was admitted for anorexia. Endoscopic findings revealed type 3 gastric cancer. Histological examination of the endoscopic biopsy revealed poorly-differentiated adenocarcinoma. We performed total gastrectomy. However, 18 days after surgery, DIC due to multiple bone metastases occurred. The patient wa... | ['Adenocarcinoma', 'Aged', 'Antimetabolites, Antineoplastic', 'Bone Neoplasms', 'Combined Modality Therapy', 'Disseminated Intravascular Coagulation', 'Drug Administration Schedule', 'Drug Combinations', 'Female', 'Gastrectomy', 'Humans', 'Oxonic Acid', 'Pyridines', 'Stomach Neoplasms', 'Tegafur'] | 16,685,168 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['C04.588.149', 'C05.116.231'], ['E02.186'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['E02.319.283'], ['D26.310'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Negative electrostatic contribution to the bending rigidity of charged membranes and polyelectrolytes screened by multivalent counterions. | Bending rigidity of a charged membrane or polyelectrolyte screened by monovalent counterions is known to be enhanced by electrostatic effects. We show that in the case of screening by multivalent counterions the electrostatic effects reduce the bending rigidity. This inversion of the sign of the electrostatic contribut... | ['Cations', 'DNA', 'Elasticity', 'Lipid Bilayers', 'Membranes, Artificial', 'Models, Biological', 'Models, Chemical', 'Polyamines', 'Polyelectrolytes', 'Polymers', 'Static Electricity', 'Thermodynamics'] | 11,970,642 | [['D01.248.497.300'], ['D13.444.308'], ['G01.374.590'], ['D10.570.510', 'J01.637.087.500.510'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['E05.599.395'], ['E05.599.495'], ['D02.092.782'], ['D01.248.700', 'D05.750.230'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.358.500.249.820'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. | The activity of the coagulation system is regulated, in part, by the interaction of thrombin with the endothelial cell receptor thrombomodulin with subsequent generation of activated protein C and suppression of thrombin production. Our previous investigation demonstrated that ablation of the thrombomodulin gene in mic... | ['Animals', 'Blood Coagulation', 'Embryonic and Fetal Development', 'Enzyme Activation', 'Female', 'Fertility', 'Fibrin', 'Fibrinolysis', 'Homozygote', 'Mice', 'Mice, Mutant Strains', 'Mutagenesis, Site-Directed', 'Placenta', 'Point Mutation', 'Pregnancy', 'Protein C', 'Thrombomodulin', 'Thrombosis', 'Tissue Distributi... | 9,576,763 | [['B01.050'], ['G09.188.390.150'], ['G07.345.500.325', 'G08.686.784.170'], ['G02.111.263', 'G03.328'], ['G08.686.210'], ['D12.776.124.270'], ['G09.188.390.150.390'], ['G05.380.554'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550'], ['E05.393.420.601.575'], ['A16.710'], ['G05... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation of Black Hoof medicinal mushroom Phellinus linteus (Berk. et M.A. Curt.) Teng (Aphyllophoromycetideae) beta-glucan sulfate and in vitro tumor cell growth inhibitory activity. | Polysaccharide beta-glucans were extracted from the medicinal mushroom Phellinus linteus (Hymenochaetaceae, Aphyllophoromycetideae) and subjected to sulfation. Chemical modification of the beta-glucan was confirmed by structural analysis, and its biological properties were compared with those of native beta-glucan. The... | ['Agaricales', 'Antineoplastic Agents', 'Cell Line, Tumor', 'Cell Proliferation', 'Colonic Neoplasms', 'Drug Screening Assays, Antitumor', 'Humans', 'Nitric Oxide', 'Phellinus', 'Plant Extracts', 'Polysaccharides', 'Sulfates', 'beta-Glucans'] | 22,135,887 | [['B01.300.179.100'], ['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A clinical, neurophysiological and molecular study of 12 patients from 4 families with spinal and bulbar muscular atrophy]. | INTRODUCTION: Spinal and bulbar muscular atrophy (SBMA) is an X-linked, late-onset neuro-endocrine disorder resulting from an expansion of a CAG repeat in the androgen receptor gene. Material and method. We report the detailed phenotypic study in a series of 12 SBMA patients evaluated in four kindreds.RESULTS: Clinical... | ['Adolescent', 'Adult', 'Child', 'Female', 'Humans', 'Middle Aged', 'Muscular Atrophy, Spinal', 'Muscular Disorders, Atrophic', 'Pedigree'] | 15,924,079 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.854.468', 'C10.574.562.500', 'C10.668.467.500'], ['C05.651.534', 'C10.668.491.175'], ['E05.393.673']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparative study of the interactions of cisplatin and carboplatin with nucleotides using UV resonance Raman spectroscopy. | We have obtained the UV excited resonance Raman spectra of five mononucleotides bound to cisplatin and to carboplatin using excitation in resonance with the first electronic absorption bands of the nucleotide bases. Substantial changes in the spectra are observed following interaction with both platinum drugs, indicati... | ['Carboplatin', 'Cisplatin', 'Drug Interactions', 'Nucleotides', 'Spectrophotometry, Ultraviolet', 'Spectrum Analysis, Raman'] | 8,241,424 | [['D02.257.125'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['G07.690.773.968'], ['D09.408.620', 'D13.695'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['E05.196.822.860', 'E05.196.867.890']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determinants of lifestyle counseling and current practices: A cross-sectional study among Dutch general practitioners. | This study aimed to examine the amount of lifestyle counseling that Dutch general practitioners (GPs) generally provide to their patients, as well as the behavioral determinants of their lifestyle counseling practices. Lifestyle counseling was defined and operationalized through the 5As model (i.e. Assess, Advise, Agre... | ['Adult', 'Aged', 'Attitude of Health Personnel', 'Counseling', 'Cross-Sectional Studies', 'Female', 'General Practitioners', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Life Style', 'Male', 'Middle Aged', "Practice Patterns, Physicians'", 'Surveys and Questionnaires'] | 32,692,740 | [['M01.060.116'], ['M01.060.116.100'], ['F01.100.050', 'N05.300.100'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['M01.526.485.810.485', 'N02.360.810.485'], ['F01.145.488'], ['F01.100.150.500', 'N05.300.150.410'],... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Biologically active recombinant human complement factor H: synthesis and secretion by the baculovirus system. | A complete cDNA clone (4.3 kb) encoding human complement factor H (hCFH; 155 kDa) has been cloned into the pVL1393 baculovirus expression vector and transfected into Spodoptera frugiperda Sf9 insect cells. A biologically active (92 +/- 15%) 140-kDa protein was secreted into the medium with a yield of more than 5 mg/lit... | ['Animals', 'Baculoviridae', 'Complement C3b', 'Complement Factor H', 'Genetic Vectors', 'Humans', 'Moths', 'Recombinant Proteins'] | 8,206,393 | [['B01.050'], ['B04.280.065', 'B04.525.100'], ['D12.776.124.486.274.250.260'], ['D12.776.124.486.274.920.325.200', 'D12.776.124.790.223.200', 'D12.776.377.715.182.200'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.500.131.617.720.500.500.937.650'], ['D12.776.828']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Integrin messenger RNAs in the red nucleus after axotomy and neurotrophic administration. | Integrins are cell surface receptors known to be important for regeneration in the peripheral nervous system. We have investigated the expression of integrin messenger RNAs in red nucleus neurons of adult rats after axotomy and administration of neurotrophic factors. Using radioactive in situ hybridization, messenger R... | ['Animals', 'Antigens, CD', 'Autoradiography', 'Axotomy', 'Brain-Derived Neurotrophic Factor', 'Female', 'In Situ Hybridization', 'Integrin alpha Chains', 'Integrin alpha3', 'Integrin alphaV', 'Integrin beta1', 'Nerve Regeneration', 'Neurotrophin 3', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Red Nucleus', 'Spi... | 15,858,411 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['E04.525.210.158'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. | CYP3A4 is an important determinant of drug-drug interactions. In this study, we evaluated whether cytochrome P450 3A knockout mice [Cyp3a(-/-)] and CYP3A4 transgenic (CYP3A4-Tg) mice can be used to study drug-drug interactions in the liver and intestine. Triazolam was used as a probe drug because it is a highly specifi... | ['Administration, Oral', 'Animals', 'Antineoplastic Agents', 'Cytochrome P-450 CYP3A', 'Cytochrome P-450 CYP3A Inhibitors', 'Cytochrome P-450 Enzyme Inhibitors', 'Cytochrome P-450 Enzyme System', 'Drug Interactions', 'Enzyme Activators', 'Enzyme Inhibitors', 'Gefitinib', 'Humans', 'Hydroxylation', 'Intestines', 'Ketoco... | 19,752,211 | [['E02.319.267.100'], ['B01.050'], ['D27.505.954.248'], ['D08.244.453.860.500', 'D08.811.682.662.582.353', 'D08.811.682.690.708.170.495.500', 'D12.776.422.220.453.860.500'], ['D27.505.389.500.503', 'D27.505.519.389.335.503'], ['D27.505.389.500', 'D27.505.519.389.335'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.77... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of mitomycin in upper digestive tract stricture. | BACKGROUND: Mitomycin C is an anti-fibroblast chemotherapeutic agent that has demonstrated promise in the treatment of head and neck cancer-related cervical stenosis. The present study investigates whether the application of mitomycin C at the time of dilation is both safe and effective in the treatment of head and nec... | ['Adenocarcinoma', 'Aged', 'Aged, 80 and over', 'Antibiotics, Antineoplastic', 'Carcinoma, Squamous Cell', 'Deglutition Disorders', 'Dilatation', 'Esophageal Stenosis', 'Female', 'Follow-Up Studies', 'Head and Neck Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Mitomycin', 'Retrospective Studies', 'Treatment Outcome'] | 17,022,087 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248.106'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C06.405.117.119', 'C09.775.174'], ['E05.284'], ['C06.405.117.544'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C04.588.443'... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of C-reactive protein and albumin excretion as prognostic markers for 10-year mortality after myocardial infarction. | BACKGROUND: C-reactive protein (CRP) is an established prognostic marker in the setting of acute coronary syndromes. Recently, albumin excretion rate also has been found to be associated with adverse outcomes in this clinical setting. Our aim was to compare the prognostic power of CRP and albumin excretion rate for lon... | ['Aged', 'Albuminuria', 'Biomarkers', 'C-Reactive Protein', 'Cause of Death', 'Chi-Square Distribution', 'Creatinine', 'Discriminant Analysis', 'Female', 'Humans', 'Italy', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Predictive Value of Tests', 'Prognosis', 'Proportional Hazards Models', '... | 20,734,449 | [['M01.060.116.100'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['D23.101'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E05.318.740.994.300', 'G17.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Neuromodulation of the locomotor network by dopamine in the isolated spinal cord of newborn rat. | We have analysed the action of the neuromodulatory catecholamine, dopamine (DA), on the lumbar locomotor network using an isolated in vitro newborn rat spinal cord preparation. We have also attempted to determine the respective contribution of the D1- and D2-like receptors on the dopamine-mediated effects. Bath applica... | ['Animals', 'Animals, Newborn', 'Benzazepines', 'Dopamine', 'Female', 'In Vitro Techniques', 'Male', 'Motor Activity', 'Nerve Net', 'Neurotransmitter Agents', 'Rats', 'Rats, Wistar', 'Receptors, Dopamine', 'Spinal Cord'] | 15,016,090 | [['B01.050'], ['B01.050.050.282'], ['D03.633.100.079'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E05.481'], ['F01.145.632', 'G11.427.410.698'], ['A08.511'], ['D27.505.519.625', 'D27.505.696.577'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of indirect and avidin-biotin enzyme linked immunosorbent assays for detection of anti-listeriolysin O antibodies in bovine milk samples. | Listeria monocytogenes is a foodborne pathogen that causes a wide spectrum of diseases in humans and animals. Enzyme linked immunosorbent assays (ELISA) [indirect and avidin-biotin (A-B)] for detecting L. monocytogenes antibodies in bovine milk samples (n = 2060) were standardized and evaluated by comparison with bacte... | ['Animals', 'Antibodies, Bacterial', 'Avidin', 'Biotin', 'Cattle', 'Dairying', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Food Microbiology', 'Humans', 'India', 'Listeria monocytogenes', 'Milk', 'Predictive Value of Tests', 'ROC Curve', 'Sensitivity and Specificity'] | 17,894,640 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.034.614.300', 'D12.776.256.159.157.663.300', 'D12.776.290.663.100', 'D12.776.395.175'], ['D03.383.129.308.080', 'D08.211.096'], ['B01.050.150.900.649.313.500.380.271'], ['J01.040.246'], ['E05.478.566.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Can adenocarcinoma in situ of the uterine cervix be treated safely by conisation in combination with endocervical curettage? | OBJECTIVE: To evaluate the prognostic value of endocervical curettage (ECC) after conisation in patients treated for adenocarcinoma in situ (AIS) of the uterine cervix.MATERIALS AND METHODS: Patients with AIS diagnosed between 1990 and 2010 and with a minimum of 1.5 years of follow-up were retrospectively identified us... | ['Adenocarcinoma in Situ', 'Adult', 'Aged', 'Conization', 'Curettage', 'Female', 'Humans', 'Hysterectomy', 'Middle Aged', 'Uterine Cervical Neoplasms'] | 25,556,275 | [['C04.557.470.200.025.014', 'C04.557.470.200.240.124', 'C23.149.249'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100.160', 'E01.370.225.998.054.160', 'E01.370.388.100.160', 'E04.074.160', 'E05.200.500.384.100.160', 'E05.200.998.054.160', 'E05.242.384.100.160'], ['E04.157'], ['B01.050.150.900.649.313.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Caring for a demented elderly person--burden and burnout among caregiving relatives. | Fifty-two family caregivers for demented elderly people were investigated for burden and burnout experiences. A structured burden questionnaire and the Burnout Measure were used. Burnout is described in relation to the caregiver's gender, age, family relationship and the demented person's living place. Older wives and ... | ['Adult', 'Aged', 'Caregivers', 'Dementia', 'Female', 'Health Status', 'Home Nursing', 'Humans', 'Male', 'Middle Aged', 'Risk Factors', 'Stress, Psychological', 'Sweden'] | 9,004,018 | [['M01.060.116'], ['M01.060.116.100'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['C10.228.140.380', 'F03.615.400'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['E02.760.611.470', 'N02.421.143.524.470', 'N02.421.533.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Age, puberty, body dissatisfaction, and physical activity decline in adolescents. Results of the German Health Interview and Examination Survey (KiGGS). | BACKGROUND: Physical activity (PA) shows a marked decline during adolescence. Some studies have pointed to pubertal status or timing as possible PA determinants in this age group. Furthermore, it was supposed that the impact of pubertal changes on PA might be mediated by psychological variables like body dissatisfactio... | ['Adolescent', 'Age Factors', 'Body Image', 'Child', 'Exercise', 'Female', 'Germany', 'Health Surveys', 'Humans', 'Male', 'Puberty', 'Social Class'] | 22,032,266 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.752.747.792.110', 'F02.463.593.112'], ['M01.060.406'], ['G11.427.410.698.277', 'I03.350'], ['Z01.542.315'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.760', 'G08... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects of endolymphatic and perilymphatic application of salicylate in the pigeon. II: Fine structure of auditory hair cells. | Large doses of salicylate are known to cause reversible ototoxic effects including fine structural alterations of the auditory hair cells in mammals. To investigate possible fine structural correlates of salicylate effects on pigeon auditory hair cells, the basilar papillae following perilymphatic or endolymphatic appl... | ['Animals', 'Columbidae', 'Endolymph', 'Endoplasmic Reticulum', 'Female', 'Hair Cells, Auditory', 'Hair Cells, Auditory, Outer', 'Male', 'Microscopy, Electron', 'Organelles', 'Perilymph', 'Salicylates', 'Salicylic Acid'] | 8,040,102 | [['B01.050'], ['B01.050.150.900.248.165.150'], ['A12.207.270.517.324'], ['A11.284.430.214.190.875.248'], ['A08.675.650.250', 'A08.675.650.915.750.600.350', 'A08.800.950.750.600.350', 'A09.246.300.246.577.325', 'A11.671.650.250', 'A11.671.650.915.750.600.350'], ['A08.675.650.250.315', 'A08.675.650.915.750.600.350.365', ... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dietary excess vanadium induces lesions and changes of cell cycle of spleen in broilers. | The purpose of this 42-day study was to investigate the effects of dietary excess vanadium on spleen growth and lesions by determining morphological changes and cell cycle of spleen. Four hundred twenty 1-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet as control diet or the sam... | ['Animals', 'Cell Cycle', 'Chickens', 'Dietary Supplements', 'Flow Cytometry', 'Spleen', 'Vanadium'] | 21,191,820 | [['B01.050'], ['G04.144'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.203.300.456', 'J02.500.456'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['A10.549.700', 'A15.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
ReaxFF reactive force field for the Y-doped BaZrO3 proton conductor with applications to diffusion rates for multigranular systems. | Proton-conducting perovskites such as Y-doped BaZrO 3 (BYZ) are promising candidates as electrolytes for a proton ceramic fuel cell (PCFC) that might permit much lower temperatures (from 400 to 600 degrees C). However, these materials lead to relatively poor total conductivity ( approximately 10 (-4) S/cm) because of e... | ['Barium', 'Diffusion', 'Electric Power Supplies', 'Models, Chemical', 'Oxygen', 'Protons', 'Quantum Theory', 'Temperature', 'Yttrium', 'Zirconium'] | 18,925,731 | [['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['G01.202', 'G02.196'], ['E07.305.124'], ['E05.599.495'], ['D01.268.185.550', 'D01.362.670'], ['D01.248.497.300.459.700', 'D01.268.406.750', 'D01.362.340.750', 'G01.249.660.500'], ['H01.671.579.800'], ['G01.906.595', 'G16.500.275.063.725.710... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[TULIP: transurethral ultrasound-guided laser-induced prostatectomy. Clinical results after on year]. | The TULIP (Transurethral Ultrasound-guided Laser-Induced Prostatectomy) system combines a real-time ultrasound transducer and a Nd:YAG laser delivery system with a 1.064 micron wavelength within a 22 F urethral probe. The goal is to produce a coagulation necrosis of the prostatic parenchyma, with a subsequent eliminati... | ['Follow-Up Studies', 'Humans', 'Laser Therapy', 'Male', 'Organ Size', 'Postoperative Complications', 'Prostatectomy', 'Prostatic Hyperplasia', 'Ultrasonography', 'Urodynamics'] | 7,691,968 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['C23.550.767'], ['E04.950.774.860.625'], ['C12.294.565.500'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Potentiation of pulmonary arteriolar vasoconstriction to endothelin-1 by inhibition of nitric oxide synthesis in the intact lung. | OBJECTIVE: To observe pulmonary arteriolar effects of endothelin-1 (ET-1) in the intact lung and determine if constriction to ET-1 is potentiated by inhibition of nitric oxide (NO) synthesis.METHODS: In anesthetized male Sprague-Dawley rats with open chest, the lungs were ventilated with air through the lower trachea a... | ['Animals', 'Arterioles', 'Endothelin-1', 'Enzyme Inhibitors', 'Male', 'Microcirculation', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase Type III', 'Pulmonary Alveoli', 'Rats', 'Rats, Sprague-Dawley', 'Vasoconstriction'] | 9,866,120 | [['B01.050'], ['A07.015.114.060', 'A07.015.461.080'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['D27.505.519.389'], ['G09.330.100.645'], ['D12.125.068.050.525', 'D12.125.095.104.525'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D08.811.682.664.500.772'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of echocardiography in acute pulmonary embolism. | The difficulty in making an accurate diagnosis of acute pulmonary embolism is well known. To clarify the role of echocardiography, including Doppler echocardiography, in acute pulmonary embolism, we examined hemodynamic and echocardiographic parameters in 9 patients with acute pulmonary embolism just before and after t... | ['Acute Disease', 'Blood Pressure', 'Echocardiography', 'Echocardiography, Doppler', 'Heart Ventricles', 'Hemodynamics', 'Humans', 'Predictive Value of Tests', 'Pulmonary Embolism', 'Pulmonary Wedge Pressure', 'Regression Analysis', 'Thrombolytic Therapy', 'Tricuspid Valve Insufficiency', 'Urokinase-Type Plasminogen Ac... | 2,614,928 | [['C23.550.291.125'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['A07.541.560'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.4... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Recombinant N-Terminal Slit2 Inhibits TGF-â-Induced Fibroblast Activation and Renal Fibrosis. | Fibrosis and inflammation are closely intertwined injury pathways present in nearly all forms of CKD for which few safe and effective therapies exist. Slit glycoproteins signaling through Roundabout (Robo) receptors have been described to have anti-inflammatory effects through regulation of leukocyte cytoskeletal organ... | ['Animals', 'Fibroblasts', 'Fibrosis', 'Intercellular Signaling Peptides and Proteins', 'Kidney', 'Kidney Diseases', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Nerve Tissue Proteins', 'Recombinant Proteins', 'Transforming Growth Factor beta'] | 26,869,008 | [['B01.050'], ['A11.329.228'], ['C23.550.355'], ['D12.644.276', 'D12.776.467', 'D23.529'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D12.776.631'], ['D12.776.828'], ['D12.644.276... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uterine epithelial cells in primary culture: a model system to study cell proliferation. | Guinea-pig uterine glandular epithelial cells were grown in primary culture. During the 4-day initial culture period, a 6.7 fold increase in DNA synthesis and a doubling time of approximately 30 hours were observed. Then the cells were submitted to serum depletion (60 hours) and the quiescent cells were stimulated with... | ['Animals', 'Cell Division', 'Cells, Cultured', 'DNA', 'Epithelial Cells', 'Epithelium', 'Female', 'Gene Expression', 'Models, Biological', 'Proto-Oncogenes', 'Uterus'] | 2,279,266 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D13.444.308'], ['A11.436'], ['A10.272'], ['G05.297'], ['E05.599.395'], ['G05.360.340.024.340.375.500.791'], ['A05.360.319.679']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between total-Tau and brain atrophy one year after first-ever stroke. | BACKGROUND: Although the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural MRI and pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau... | ['Aged', 'Aged, 80 and over', 'Atrophy', 'Biomarkers', 'Brain', 'Female', 'Follow-Up Studies', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neurodegenerative Diseases', 'Neurofibrillary Tangles', 'Stroke', 'tau Proteins'] | 28,583,116 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.300.070'], ['D23.101'], ['A08.186.211'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of depressive symptoms, state anxiety, and pure-tone thresholds on the tinnitus handicap inventory in Japan. | OBJECTIVE: To assess factors that contribute to Tinnitus Handicap Inventory (THI) scores in Japan.DESIGN: Case series with chart review.STUDY SAMPLE: Two hundred and eighty-five tinnitus patients at tertiary referral center, who completed the Japanese version of the THI, the Self-rating Depression Scale (SDS), and the ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anxiety', 'Asian Continental Ancestry Group', 'Audiometry, Pure-Tone', 'Auditory Threshold', 'Depression', 'Disability Evaluation', 'Female', 'Hearing Loss', 'Humans', 'Japan', 'Linear Models', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Risk Assessment', 'Risk Factors',... | 21,495,790 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.470.132'], ['M01.686.508.200'], ['E01.370.382.375.060.055'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['F01.145.126.350'], ['E01.370.400'], ['C09.218.458.341', 'C10.597.751.418.341', 'C23.888.592.763.393.341'], ['B01.050.150... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The gelatinolytic activity of human skin fibroblast collagenase. | The gelatinolytic activity of human skin fibroblast collagenase was examined on denatured collagen types I-V. All denatured substrates were cleaved, including types IV and V, which are resistant to collagenase in native form. Interestingly, the earliest major cleavage in denatured collagen types I-III occurred at a 3/4... | ['Cells, Cultured', 'Collagen', 'Fibroblasts', 'Gels', 'Humans', 'Kinetics', 'Microbial Collagenase', 'Protein Denaturation', 'Skin', 'Substrate Specificity'] | 6,288,690 | [['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A11.329.228'], ['D20.280.320', 'D26.255.165.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D08.811.277.656.300.480.205.500', 'D08.811.277.656.675.374.205.500'], ['G01.154.651.750.500', 'G02.111.688.750.500'], ['A17.81... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy. | OBJECTIVE: Limited neuronal cell loss is seen in the neuropathology of Wernicke's encephalopathy (WE), but the extent of neuronal damage has not been well studied. Moreover, there is still a debate as to whether alcohol itself causes brain damage in humans. Although, it is difficult to examine the extent of neuronal da... | ['Adult', 'Aged', 'Alcohol Amnestic Disorder', 'Alcohol Withdrawal Delirium', 'Alcoholism', 'Alzheimer Disease', 'Humans', 'Male', 'Middle Aged', 'Wernicke Encephalopathy', 'tau Proteins'] | 18,445,112 | [['M01.060.116'], ['M01.060.116.100'], ['C10.720.112.100', 'C25.723.705.150.100', 'C25.775.100.087.193.100', 'F03.900.100.050'], ['C10.720.112.200', 'C25.723.705.150.200', 'C25.775.100.087.193.200', 'C25.775.835.250', 'F03.900.100.100', 'F03.900.825.500'], ['C25.775.100.250', 'F03.900.100.350'], ['C10.228.140.380.100',... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An alternative approach for screening active bam HI variants: overexpression in T-7 RNA polymerase based system. | The type II restriction endonuclease, Bam HI, has been overexpressed in E. coli by cloning the Bam HI gene in frame with an E. coli Ribosome Binding Site (RBS) under the T7 promoter of an E. coli expression vector pRSET A. The expression level of Bam HI endonuclease using this construct was found to be higher than that... | ['Binding Sites', 'Cell Division', 'Cells, Cultured', 'DNA-Directed RNA Polymerases', 'Deoxyribonuclease BamHI', 'Mutation', 'Plasmids', 'Recombinant Proteins', 'Viral Proteins'] | 11,886,077 | [['G02.111.570.120'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D08.811.913.696.445.735.270'], ['D08.811.150.280.260.240', 'D08.811.277.352.335.350.300.260.240', 'D08.811.277.352.355.325.300.260.240'], ['G05.365.590'], ['G05.360.600'], ['D12.776.828'], ['D12.776.964']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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