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A non-invasive computerized measurement of motor neurone refractory period and subnormal conduction in man. | A computer-assisted method is described which allows the non-invasive measurement of excitability and conduction velocity during the relative refractory period of alpha motor fibres in peripheral nerves. The method is based on a collision technique combined with a correlation analysis of the compound muscle potential. ... | ['Action Potentials', 'Computers', 'Electrodiagnosis', 'Humans', 'Muscles', 'Neural Conduction', 'Refractory Period, Electrophysiological', 'Skin Temperature'] | 6,165,554 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['L01.224.230.260'], ['E01.370.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633', 'A10.690'], ['G07.265.753', 'G11.561.601'], ['G07.265.753.770', 'G07.265.760', 'G11.561.601.770', 'G11.561.785'], ['G07.110.753', 'G13.750.844']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Phenol photonitration upon UV irradiation of nitrite in aqueous solution I: effects of oxygen and 2-propanol. | Nitrophenols are formed in aqueous solution upon UV irradiation of phenol and nitrite. The formation of nitrophenols is enhanced by dissolved oxygen and inhibited by the addition of 2-propanol. The mechanism of phenol photonitration involves both .NO2 (or N2O4, reacting with phenol, and 4-nitrosophenol, which is oxidis... | ['2-Propanol', 'Nitrites', 'Nitrophenols', 'Oxidation-Reduction', 'Oxygen', 'Photolysis', 'Solubility', 'Ultraviolet Rays', 'Water Pollutants, Chemical'] | 11,695,611 | [['D02.033.755.615'], ['D01.248.497.158.635', 'D01.625.600.600', 'D02.633'], ['D02.455.426.559.389.657.566', 'D02.640.743'], ['G02.700', 'G03.295.531'], ['D01.268.185.550', 'D01.362.670'], ['G02.740.685'], ['G02.805'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Motor recovery patterns in arm muscles: coupled bilateral training and neuromuscular stimulation. | BACKGROUND: Neuromuscular stimulation coupled with bilateral movements facilitates functional motor recovery of the upper extremities post stroke. This study investigated electromyography activation patterns during training. The leading question asked: Do EMG activation patterns show rehabilitative effects of coupled b... | ['Aged', 'Arm', 'Electric Stimulation Therapy', 'Electromyography', 'Exercise Therapy', 'Female', 'Humans', 'Male', 'Muscle, Skeletal', 'Recovery of Function', 'Stroke', 'Stroke Rehabilitation'] | 24,725,731 | [['M01.060.116.100'], ['A01.378.800.075'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E01.370.405.255', 'E01.370.530.255'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['G16.757'], ['C10.228.140.300.775', 'C14.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Development, survivorship and reproduction of Helicoverpa armigera (Lepidoptera: Noctuidae) under fluctuating temperatures. | Laboratory studies were conducted to assess the effect of temperature on the survival, development, longevity and fecundity of Helicoverpa armigera (Lepidoptera: Noctuidae) at eight different fluctuating temperatures with an amplitude ±9 °C under constant photoperiodic conditions of 16:8 h (L:D). H. armigera achieved c... | ['Animals', 'Climate Change', 'Female', 'Larva', 'Longevity', 'Male', 'Moths', 'Ovum', 'Pupa', 'Reproduction', 'Temperature'] | 25,208,831 | [['B01.050'], ['G16.500.175.374'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G07.345.124.519', 'G07.540'], ['B01.050.500.131.617.720.500.500.937.650'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['B05.500.700', 'G07.345.500.550.500.700'], ['G08.686.784'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Striated fibers in trichomonads: costa proteins represent a new class of proteins forming striated roots. | The production of monoclonal antibodies and the use of biochemical techniques revealed that B-type costa proteins in trichomonads are composed of several major polypeptides with molecular weight detected between 100 and 135 kDa similar to those found in the A-type costae. Although differences were observed between the ... | ['Animals', 'Antibodies, Monoclonal', 'Antibodies, Protozoan', 'Cross Reactions', 'Cytoskeleton', 'Fluorescent Antibody Technique', 'Immunoblotting', 'Immunohistochemistry', 'Organelles', 'Protozoan Proteins', 'Species Specificity', 'Trichomonadida'] | 7,820,860 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['G12.122.281'], ['A11.284.430.214.190.750'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.20... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Olfactory receptors in human airway epithelia. | Olfactory receptors (OR) represent one of the largest gene families in the human genome. In spite of a significant progress in deciphering the physiological functions of olfactory receptors, how the majority of these G-protein-coupled receptors are activated is still mostly a mystery. Consequently, for the majority of ... | ['Cell Culture Techniques', 'Epithelium', 'Fluorescent Antibody Technique', 'Humans', 'In Situ Hybridization', 'Intracellular Space', 'Microscopy, Confocal', 'Paraffin', 'Protein Transport', 'Receptors, Odorant', 'Respiratory System', 'Staining and Labeling'] | 23,585,041 | [['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A10.272'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325', 'E01.370.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nutrient release, recovery and removal from waste sludge of a biological nutrient removal system. | The uncontrolled release of nutrients from waste sludge results in nitrogen and phosphorus overloading in wastewater treatment plants when supernatant is returned to the inlet. A controlled release, recovery and removal of nutrient from the waste sludge of a Biological Nutrient Removal system (BNR) are investigated. Re... | ['Bacteria', 'Biological Oxygen Demand Analysis', 'Biopolymers', 'Bioreactors', 'Carbon', 'Chemical Precipitation', 'Crystallization', 'DNA, Bacterial', 'Hydrolysis', 'In Situ Hybridization, Fluorescence', 'Magnesium Compounds', 'Nitrogen', 'Phosphates', 'Phosphorus', 'Sewage', 'Struvite', 'Waste Disposal, Fluid', 'Wat... | 25,176,308 | [['B03'], ['N06.850.460.350.080.500', 'N06.850.780.375.349'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['E07.115', 'J01.897.120.115'], ['D01.268.150'], ['E05.196.150', 'G02.159'], ['E05.196.300', 'G02.171'], ['D13.444.308.212'], ['G02.380'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Regional cerebral glucose metabolism of patients with malignant diseases in different clinical phases. | BACKGROUND: Psychological and psychiatric aspects of cancer patients have not been studied well in terms of functional neuroimaging. The aim of this pilot study was to investigate the relationship between regional cerebral metabolism and different clinical phases.MATERIAL AND METHODS: Relative cerebral glucose metaboli... | ['Brain', 'Cross-Sectional Studies', 'Disease Progression', 'Glucose', 'Humans', 'Neoplasms', 'Tomography, Emission-Computed'] | 11,257,726 | [['A08.186.211'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C23.550.291.656'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['E01.370.350.350.800', 'E01.370.350.600.350.800', 'E01.370.350.710.800', 'E01.370.350.825.800', 'E01.370.384.730.800']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fine structure of cartilage elastic system fibers, in particular those of the mandibular condyle. | Light microscopy of the mandibular joint tissues from fetal mice show a distribution of fibrillar structures in the articular fibrous capsule covering the condylar head. Further SEM and TEM studies were conducted on autoclaved xiphoid and mandibular condylar processes of the fetuses for observation of the elastic syste... | ['Animals', 'Cartilage', 'Collagen', 'Elastic Tissue', 'Elastin', 'Embryonic and Fetal Development', 'Mandibular Condyle', 'Mice', 'Mice, Inbred Strains', 'Microscopy, Electron', 'Temporomandibular Joint', 'Xiphoid Bone'] | 2,640,943 | [['B01.050'], ['A02.165', 'A10.165.382'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A10.165.400'], ['D05.750.078.421', 'D12.776.860.300.350'], ['G07.345.500.325', 'G08.686.784.170'], ['A02.835.232.781.324.502.632.600', 'A14.521.632.600'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Vitamin D3 poisoning and irreversible sequela]. | Twenty-four children with vitamin D intoxication and a follow-up of one to thirteen years old (means: four years and seven months) are reviewed. Over-dosage was prescribed by medical order in 66.6% of patients and by the mother herself in 16.6%. Intensity of clinical symptoms (renal, neurologic, digestive) were related... | ['Bone Diseases, Metabolic', 'Calcinosis', 'Calcium', 'Child', 'Child, Preschool', 'Cholecalciferol', 'Female', 'Humans', 'Hypertension', 'Infant', 'Male', 'Nephrocalcinosis'] | 2,984,970 | [['C05.116.198', 'C18.452.104'], ['C18.452.174.130'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['M01.060.406'], ['M01.060.406.448'], ['D04.210.500.247.222.159', 'D04.210.500.247.808.146', 'D04.210.500.812.768.196', 'D10.570.938.146'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Protein Chemical Synthesis Combined with Mirror-Image Phage Display Yields d-Peptide EGF Ligands that Block the EGF-EGFR Interaction. | The epidermal growth factor (EGF) pathway, being overactive in a number of cancers, is a good target for clinical therapy. Although several drugs targeting the EGF receptor (EGFR) are on the market, tumours acquire resistance very rapidly. As an alternative, small molecules and peptides targeting EGF have been develope... | ['Amino Acid Sequence', 'Epidermal Growth Factor', 'ErbB Receptors', 'Humans', 'Ligands', 'Models, Molecular', 'Molecular Structure', 'Peptide Library', 'Peptides'] | 31,268,623 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['E05.599.595'], ['G... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Human adipocytes express alpha 2-adrenergic receptor of the alpha 2A-subtype only: pharmacological and genetic evidence. | In the present study we have reinvestigated the subtype of alpha 2-adrenoceptors expressed in human adipocytes (from subcutaneous and internal fat deposits) by means of radioligand binding using subtype-selective antagonists, and RNase mapping using a set of specific probes prepared from human alpha 2-adrenoceptors gen... | ['Adipocytes', 'Adrenergic alpha-Antagonists', 'Adult', 'Cell Line', 'Female', 'Humans', 'Idazoxan', 'In Vitro Techniques', 'Membranes', 'Middle Aged', 'Quinolizines', 'RNA', 'RNA Probes', 'Radioligand Assay', 'Receptors, Adrenergic, alpha-2', 'Ribonucleases'] | 8,808,178 | [['A11.329.114'], ['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['M01.060.116'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308.428', 'D03.383.188.425', 'D03.633.100.355'], ['E05.481'], ['A10.615'], ['M01.060.116.630'], ['D03.633.100.834'], ['D13.444.735'], ['D13.4... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells. | BACKGROUND: Niemann-Pick type C (NPC) disease is a genetically inherited multi-lipid storage disorder with impaired efflux of cholesterol from lysosomal storage organelles.METHODOLOGY/PRINCIPAL FINDINGS: The effect of screen-selected cholesterol lowering compounds on the major sterol pathways was studied in CT60 mutant... | ['Animals', 'Anticholesteremic Agents', 'CHO Cells', 'Carrier Proteins', 'Cholesterol', 'Cricetinae', 'Cricetulus', 'Drug Evaluation, Preclinical', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Lipoproteins', 'Lysosomes', 'Membrane Glycoproteins', 'Mutation', 'Niemann-Pick Diseases', 'Small Molecule Libra... | 20,877,719 | [['B01.050'], ['D27.505.519.186.071.202', 'D27.505.954.557.500.202'], ['A11.251.210.200', 'A11.436.155'], ['D12.776.157'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['E05.290.750', 'E05.337.550... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of octylglucoside and sodium cholate in Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to soft contact lenses. | PURPOSE: In this study, the effect of the natural surfactants octylglucoside and sodium cholate in inhibiting Staphylococcus epidermidis and Pseudomonas aeruginosa adhesion to conventional and silicone-hydrogel contact lenses (CL) was assessed. Hydrophobicity was also evaluated to conditioned and nonconditioned CL.METH... | ['Bacterial Adhesion', 'Contact Lens Solutions', 'Contact Lenses, Hydrophilic', 'Glucosides', 'Humans', 'Hydrogel, Polyethylene Glycol Dimethacrylate', 'Pseudomonas aeruginosa', 'Silicones', 'Sodium Cholate', 'Staphylococcus epidermidis', 'Surface-Active Agents'] | 17,502,827 | [['G06.099.050'], ['D26.776.210', 'D27.505.954.122.425.150', 'D27.720.274.150'], ['E07.632.500.276.360'], ['D09.408.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.455.250.700.485', 'D05.750.219.500', 'D05.750.741.485', 'D20.280.320.609.500', 'D25.720.532.500', 'D25.720.741.485', 'D26.255.165.320.375.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Direct determination of vibrational density of states change on ligand binding to a protein. | The change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly relative to the unbound protein. The resulting free-energy change, which is directly determined b... | ['Deuterium Oxide', 'Escherichia coli', 'Kinetics', 'Ligands', 'Methotrexate', 'Models, Statistical', 'NADP', 'Neutrons', 'Protein Binding', 'Proteins', 'Scattering, Radiation', 'Tetrahydrofolate Dehydrogenase', 'Thermodynamics'] | 15,323,955 | [['D01.045.250.875.200', 'D01.248.497.158.459.650.200', 'D01.268.406.500.250', 'D01.362.340.500.250'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.480'], ['D03.633.100.733.631.192.500'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Factitious disorder: a rare cause of haematemesis. | Acute upper gastrointestinal (GI) bleeding is a common condition in the UK with 50-70,000 admissions per year. In 20% of cases no cause can be found on endoscopy. Here, we present the case of a young female patient who was admitted on three occasions with large volume haematemesis and bleeding from other sites. She was... | ['Catheterization, Peripheral', 'Factitious Disorders', 'Female', 'Hematemesis', 'Humans', 'Young Adult'] | 28,828,588 | [['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['F03.875.375'], ['C06.405.227.400', 'C23.550.414.788.400', 'C23.888.821.937.019'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.815']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A hospital out-patient study of timolol/bendrofluazide combination ('Prestim') in essential hypertension. | A study was carried out in 44 patients with mild to moderate essential hypertension attending a hypertension clinic in a general hospital. Treatment was administered using fixed-dose combination tablets of timolol maleate (10 mg) and bendrofluazide (2.5 mg) taken twice daily for 16 weeks, in order to assess the efficac... | ['Adolescent', 'Adult', 'Aged', 'Bendroflumethiazide', 'Drug Combinations', 'Female', 'Heart Rate', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Propanolamines', 'Timolol'] | 7,428,413 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D02.886.590.700.135.138', 'D02.886.655.500.138', 'D03.633.100.174.138'], ['D26.310'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['D02.033.100.624', 'D02.033.755.624', 'D02.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Using clopidogrel in non-ST-segment elevation acute coronary syndrome patients: a cost-utility analysis in Spain. | OBJECTIVE: The objective of this study was to estimate the cost-effectiveness of clopidogrel, administered for 1 year after hospital admission for non-ST-segment elevation acute coronary syndrome in the Spanish public health network.METHODS: A cost-utility analysis was conducted from the societal perspective. A Markov ... | ['Acute Disease', 'Adult', 'Aged', 'Aged, 80 and over', 'Clopidogrel', 'Coronary Disease', 'Cost-Benefit Analysis', 'Decision Trees', 'Drug Costs', 'Humans', 'Markov Chains', 'Middle Aged', 'Monte Carlo Method', 'Platelet Aggregation Inhibitors', 'Quality-Adjusted Life Years', 'Spain', 'Ticlopidine'] | 14,720,130 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.500.500'], ['C14.280.647.250', 'C14.907.585.250'], ['N03.219.151.125'], ['G17.162.500'], ['N03.219.151.400.350', 'N05.300.375.300'], ['B... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Generation of macrophages from early T progenitors in vitro. | Early T progenitors in the thymus have been reported to have the capacity to develop into B cells, thymic dendritic cells, and NK cells. Here we describe conditions that induce early T progenitors to develop into macrophages. Initially, we observed that early T progenitors could be induced to develop into macrophages b... | ['Animals', 'Cell Culture Techniques', 'Cell Cycle', 'Cell Differentiation', 'Cell Separation', 'Cell-Free System', 'Cells, Cultured', 'Culture Media, Conditioned', 'Drug Combinations', 'Fetus', 'Immunophenotyping', 'Interleukin-6', 'Interleukin-7', 'Macrophage Colony-Stimulating Factor', 'Macrophages', 'Mice', 'Mice, ... | 11,342,611 | [['B01.050'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.144'], ['G04.152'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.284.835.168'], ['A11.251'], ['D27.720.470.305.250', 'E07.206.250'], ['D26.310'], ['A16.378'], ['E01.370.225.812.447', 'E05.200.812.447', ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Simultaneous multitarget radiotherapy using helical tomotherapy and its combination with sorafenib for pulmonary metastases from hepatocellular carcinoma. | We evaluated radiotherapy using helical tomotherapy (HT) combined with sorafenib for treatment of pulmonary metastases from hepatocellular carcinoma (HCC). We also analyzed potential prognostic factors and further validated the combination treatment. The objective response rate in the total cohort of 45 patients treate... | ['Antineoplastic Agents', 'Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Cohort Studies', 'Combined Modality Therapy', 'Disease-Free Survival', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Kaplan-Meier Estimate', 'Liver Neoplasms', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Niacinamide', 'Phenylu... | 27,191,894 | [['D27.505.954.248'], ['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.186'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190'... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Could the high consumption of high glycaemic index carbohydrates and sugars, associated with the nutritional transition to the Western type of diet, be the common cause of the obesity epidemic and the worldwide increasing incidences of Type 1 and Type 2 diabetes? | The globally increasing incidences of Type 1 diabetes (T1DM) and Type 2 diabetes (T2DM) can have a common background. If challenged by the contemporary high level of nutritional glucose stimulation, the â-cells in genetically predisposed individuals are at risk for damage which can lead to the diseases. The fat to carb... | ['Animals', 'Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 2', 'Diet', 'Diet, Western', 'Dietary Carbohydrates', 'Energy Intake', 'Genetic Predisposition to Disease', 'Global Health', 'Glycemic Index', 'Humans', 'Hyperglycemia', 'Incidence', 'Infant Food', 'Models, Biological', 'Obesity', 'Oxidative Stress', 'Su... | 30,902,150 | [['B01.050'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C18.452.394.750.149', 'C19.246.300'], ['G07.203.650.240'], ['G07.203.650.240.310'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['G07.203.650.240.340'], ['C23.550.291.687.500', 'G05.380.355'], ['H02.403.371', 'N01.400.337'], ['G07.203.650.660.500... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Upper limb amputees: a clinic profile. | A clinic population of upper limb amputees was located to document their management and functional restoration. Of the 38 people contacted, 26 agreed to participate. Data were collected by questionnaires, and by physical and prosthetic examination. Prostheses were worn by 81% all or part of the day, 77% using active te... | ['Adult', 'Amputees', 'Arm', 'Artificial Limbs', 'Consumer Behavior', 'Female', 'Humans', 'Male', 'Occupations', 'Ontario', 'Surveys and Questionnaires'] | 3,403,501 | [['M01.060.116'], ['M01.150.100'], ['A01.378.800.075'], ['E07.695.050', 'E07.858.082.050', 'E07.858.442.050'], ['F01.145.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.547'], ['Z01.107.567.176.639'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Delayed healing of rhytidectomy flap resurfaced with CO2 laser. | Combining facial rhytidectomy with laser resurfacing, theoretically, provides the best opportunity for achieving an optimal facial rejuvenation result. Previous studies have demonstrated the pernicious effect of a deep peel on a skin flap, but the safety of treating the rhytidectomy flap with laser has not been investi... | ['Animals', 'Carbon Dioxide', 'Chi-Square Distribution', 'Epithelium', 'Humans', 'Laser Therapy', 'Rhytidoplasty', 'Safety', 'Skin Pigmentation', 'Surgical Flaps', 'Swine', 'Swine, Miniature', 'Time Factors', 'Wound Healing'] | 9,500,404 | [['B01.050'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['E02.218.765', 'E04.680.275.700'], ['N06.850.135.060.075'], ['E01.370.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fluorescence-Activated Nucleolus Sorting in Arabidopsis. | Nucleolar isolation allows exhaustive characterization of the nucleolar content. Centrifugation-based protocols are not adapted to isolation of nucleoli directly from a plant tissue because of copurification of cellular debris. We describe here a method that allows the purification of nucleoli using fluorescent-activat... | ['Arabidopsis', 'Cell Nucleolus', 'Chloroplasts', 'Chromosomal Proteins, Non-Histone', 'Flow Cytometry', 'Green Fluorescent Proteins', 'Microscopy, Fluorescence', 'Recombinant Fusion Proteins'] | 27,576,720 | [['B01.650.940.800.575.912.250.157.100'], ['A11.284.430.106.279.345.175'], ['A11.284.430.214.190.875.700.140'], ['D12.776.660.235', 'D12.776.664.235'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effectiveness of in-room air filtration and dilution ventilation for tuberculosis infection control. | Tuberculosis (TB) is a public health problem that may pose substantial risks to health care workers and others. TB infection occurs by inhalation of airborne bacteria emitted by persons with active disease. We experimentally evaluated the effectiveness of in-room air filtration systems, specifically portable air filter... | ['Filtration', 'Humans', 'Infectious Disease Transmission, Patient-to-Professional', 'Tuberculosis', 'Ventilation'] | 8,806,221 | [['E05.196.454', 'G01.280', 'G02.263'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.335.500'], ['C01.150.252.410.040.552.846'], ['N06.230.150.520']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Comparative study of rheumatoid polyarthritis with and without the Gougerot-Sj?gren syndrome. 54 cases]. | Clinical, biological and evolutive profiles of rheumatoid polyarthritis (RP) associated or not with a Gougerot-Sj?gren syndrome (GSS) were compared in two series of 27 patients matched according sex and age, and recruited among 158 patients examined during a period of 36 months. The GSS was defined by the presence, in ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arthritis, Rheumatoid', 'Female', 'HLA Antigens', 'Humans', 'Immunoglobulins', 'Male', 'Middle Aged', 'Prognosis', 'Rheumatoid Factor', "Sjogren's Syndrome"] | 3,823,777 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485', 'D12.776.124.790.651', 'D12.776.377.715.548'], ['M01.060.116.630'... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The comparison of percutaneous ethanol and polidocanol sclerotherapy in the management of simple renal cysts. | OBJECTIVE: To compare the efficacy and safety of percutaneous ethanol and polidocanol sclerotherapy in the management of simple renal cysts.MATERIALS AND METHODS: Between 2008 and 2013, symptomatic Bosniak type I renal cysts with a diameter larger than 5 cm in ultrasonography (US) or computed tomography were included i... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anti-Infective Agents, Local', 'Ethanol', 'Female', 'Follow-Up Studies', 'Humans', 'Kidney Diseases, Cystic', 'Male', 'Middle Aged', 'Polidocanol', 'Polyethylene Glycols', 'Retrospective Studies', 'Sclerosing Solutions', 'Sclerotherapy', 'Tomography, X-Ray Computed', 'Treatment O... | 25,778,818 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.187'], ['D02.033.375'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.403', 'C13.351.968.419.403'], ['M01.060.116.630'], ['D02.033... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
The use of intravenous fluorescein in the repair of large myelomeningoceles. Technical note. | Intravenous fluorescein has been found a valuable guide in the identification of necrotic skin, which can then be debrided before wound closure. Fluorescein was used in four infants undergoing repair of large myelomeningoceles with no deleterious effects. | ['Fluoresceins', 'Humans', 'Injections, Intravenous', 'Meningomyelocele', 'Necrosis', 'Skin', 'Spinal Dysraphism'] | 325,183 | [['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['C10.500.680.610', 'C16.131.666.680.610'], ['C23.550.717'], ['A17.815'], ['C10.500.680.800', 'C16.131.666.680.800']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improved Overall Survival of Mice by Reducing Lung Side Effects After High-Precision Heart Irradiation Using a Small Animal Radiation Research Platform. | PURPOSE: The aim was to reduce radiation exposure of the lung in experimental models to increase overall survival of mice to study late radiation-induced heart disease.METHODS AND MATERIALS: A new irradiation plan was established on the Small Animal Radiation Research Platform machine for local heart irradiation of mic... | ['Animals', 'Dose-Response Relationship, Radiation', 'Female', 'Heart', 'Lung', 'Mice', 'Mice, Inbred C57BL', 'Organs at Risk', 'Radiation Injuries, Experimental', 'Safety', 'Survival Analysis', 'Time Factors', 'Tomography, X-Ray Computed'] | 29,680,258 | [['B01.050'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['A07.541'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A01.635'], ['C26.733.720', 'E05.598.500.750',... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Insulin-Like Growth Factor Binding Protein-Related Protein 1 Inhibit Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. | PURPOSE: To explore the inhibitory effect of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) on retinal angiogenesis and its underlying molecular mechanisms in the mouse model of oxygen-induced retinopathy (OIR).METHODS: C57BL/6J mice were classified into three groups as control group, OIR noni... | ['Animals', 'Disease Models, Animal', 'Insulin-Like Growth Factor Binding Proteins', 'Mice', 'Mice, Inbred C57BL', 'Oxygen', 'Retinal Neovascularization', 'Retinal Vessels'] | 28,402,720 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.157.420'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D01.268.185.550', 'D01.362.670'], ['C11.768.725', 'C23.550.589.500.725'], ['A07.015.611']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Progression of Type 2 Helper T Cell-Type Inflammation and Airway Remodeling in a Rodent Model of Naturally Acquired Subclinical Primary Pneumocystis Infection. | Subclinical primary Pneumocystis infection is the most common pulmonary infection in early infancy, making it important to determine whether it damages the lung. Pneumocystis peaks at 2 to 5 months of age, when respiratory morbidity coincidently increases. We have documented that Pneumocystis increases mucus production... | ['Animals', 'Bronchioles', 'Disease Models, Animal', 'Disease Progression', 'Extracellular Matrix', 'Female', 'Gene Expression Regulation', 'Immunocompetence', 'Inflammation Mediators', 'Mucus', 'NF-kappa B', 'Pneumonia, Pneumocystis', 'RNA, Messenger', 'Rats, Sprague-Dawley', 'Respiratory Mucosa', 'Signal Transduction... | 29,169,991 | [['B01.050'], ['A04.411.125.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['A11.284.295.310'], ['G05.308'], ['G12.460'], ['D23.469'], ['A12.200.503'], ['D05.500.672', 'D12.776.260.600', 'D12.776.660.600', 'D12.776.930.600'], ['C01.150.703.534.700', 'C01.150.703.770.700', 'C01.748.435.700', ... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mentally represented motor actions in normal aging. I. Age effects on the temporal features of overt and covert execution of actions. | The present study examines the temporal features of overt and covert actions as a function of normal aging. In the first experiment, we tested three motor tasks (walking, sit-stand-sit, arm pointing) that did not imply any particular spatiotemporal constraints, and we compared the duration of their overt and covert exe... | ['Adult', 'Aged', 'Aging', 'Analysis of Variance', 'Female', 'Humans', 'Imagination', 'Intention', 'Male', 'Motor Skills', 'Task Performance and Analysis', 'Time Factors'] | 16,165,229 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['F01.658.650', 'F02.463.306'], ['F02.808.260'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['G01.910.857']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prognostic value of six minute walk test in cystic fibrosis adults. | BACKGROUND: The 6 min walk test (6MWT) provides prognostic information in various respiratory diseases, but limited data exist in cystic fibrosis (CF) adults.METHODS: Consecutive CF adults who performed 6MWT at Cochin Hospital (Paris, France) over 12 years were analyzed. The cut-off 6 min walking distance (6MWD) value ... | ['Adult', 'Cystic Fibrosis', 'Exercise Test', 'Female', 'Forced Expiratory Volume', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Oxygen', 'Prognosis', 'ROC Curve', 'Walking'] | 24,157,200 | [['M01.060.116'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], [... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Mutant presenilin 2 causes abnormality in the brain lipid profile in the development of Alzheimer's disease. | Mutation in the presenilin 2 (PS2mt) is known to be one of factors involved in the development of Alzheimer's disease (AD). It was recently revealed that an abnormality of lipid metabolism is a phenomenon occurring in AD. Therefore, the aim of this study was to investigate the potential relationship between the mutatio... | ['Age Factors', 'Alzheimer Disease', 'Animals', 'Brain', 'Cholesterol', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Colorimetry', 'Lipid Metabolism', 'Lipoproteins', 'Mice', 'Mice, Transgenic', 'Mutation', 'Presenilin-2', 'Triglycerides'] | 17,121,184 | [['N05.715.350.075', 'N06.850.490.250'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['B01.050'], ['A08.186.211'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500... | ['Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. | BACKGROUND: Allergic rhinitis (AR) is characterized in part by hyperresponsiveness to nonspecific stimuli, a phenomenon that reflects the fundamental role of nasal neural pathways in chronic airway inflammation. Neurotrophins may serve pivotal roles in mediating hyperresponsiveness in allergic airway disease, although ... | ['Adolescent', 'Adult', 'Aged', 'Brain-Derived Neurotrophic Factor', 'Child', 'Child, Preschool', 'Chronic Disease', 'Female', 'Gene Expression Regulation', 'Humans', 'Male', 'Middle Aged', 'Mucous Membrane', 'Nasal Polyps', 'Nerve Growth Factor', 'Neuroimmunomodulation', 'Paranasal Sinuses', 'Rhinitis', 'Sinusitis', '... | 19,958,603 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A10.615.550'], ['C08.460.572',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinicopathological analysis of 114 cases of typical Kaposi's sarcoma in Xinjiang Uygur autonomous region, China. | The present study aimed to investigate the clinicopathological features of cases of classic Kaposi's sarcoma (CKS) in Xinjiang Uygur Autonomous Region, China, and analyze its etiology and treatment. A total of 114 patients, who were clinicopathologically diagnosed with CKS at the First Affiliated Hospital of Xinjiang M... | ['Adolescent', 'Adult', 'Age of Onset', 'Aged', 'Aged, 80 and over', 'Biopsy', 'China', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Sarcoma, Kaposi', 'Skin', 'Young Adult'] | 28,849,228 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['Z01.252.474.164'], ['B01.050.150.900.649.313.9... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Conformational analysis in a multidimensional energy landscape: study of an arginylglutamate repeat. | The identification of the distinct conformation classes of a molecule is a common and often crucial step in establishing structure-function relationships. Many different methods have been suggested for that purpose which differ in their choice of a (dis)similarity measure and clustering algorithm. The present study dis... | ['Dipeptides', 'Hydrogen-Ion Concentration', 'Molecular Dynamics Simulation', 'Oligopeptides', 'Principal Component Analysis', 'Protein Conformation', 'Repetitive Sequences, Amino Acid', 'Thermodynamics'] | 19,778,072 | [['D12.644.456.345'], ['G02.300'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D12.644.456'], ['E05.318.740.562'], ['G02.111.570.820.709'], ['G02.111.570.060.720', 'G02.111.570.820.709.275.875'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The effects of itraconazole on the immune responses in ICR mice. | Effects of itraconazole (ICZ) on the immune responses were studied in ICR mice. Mice were divided into 5 groups (10 mice/group), and ICZ at doses of 10, 20, 40 and 80 mg/kg were orally administered to mice once a day for 21 days. Mice were immunized and challenged with sheep red blood cells (SRBC). The body weight gain... | ['Animals', 'Antibody-Producing Cells', 'Body Weight', 'Dose-Response Relationship, Drug', 'Erythrocytes', 'Hemagglutination Tests', 'Hypersensitivity, Delayed', 'Immunity', 'Immunization', 'Itraconazole', 'Leukocyte Count', 'Lymphoid Tissue', 'Male', 'Mice', 'Mice, Inbred ICR', 'Organ Size', 'Phagocytes', 'Sheep'] | 8,207,763 | [['B01.050'], ['A11.063', 'A15.382.032'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E05.478.59... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Linkage of multiequilibria in DNA recognition by the D53H Escherichia coli cAMP receptor protein. | The transcription factor cyclic AMP receptor protein, CRP, regulates the operons that encode proteins involved in translocation and metabolism of carbohydrates in Escherichia coli. The structure of the CRP-cAMP complex reveals the presence of two sets of cAMP binding sites. Solution biophysical studies show that there ... | ['Amino Acid Substitution', 'Aspartic Acid', 'Binding Sites', 'Cyclic AMP', 'Cyclic AMP Receptor Protein', 'Cyclic GMP', 'DNA, Bacterial', 'DNA-Binding Proteins', 'Escherichia coli Proteins', 'Galactose', 'Histidine', 'Kinetics', 'Lactose', 'Point Mutation', 'Protein Binding', 'Protein Conformation', 'Thermodynamics'] | 12,475,242 | [['E05.393.420.601.035', 'G05.558.109'], ['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['G02.111.570.120'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D12.776.930.165'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased gene transfer in acute myeloid leukemic cells by an adenovirus vector containing a modified fiber protein. | Applications of gene transfer in acute myeloid leukemia (AML) blast cells have still not been developed, mostly due to the lack of an efficient vector. Adenoviruses have many advantages as vectors, but remain poorly efficient in cells lacking fiber receptors. A promising strategy is the retargeting of adenoviruses to o... | ['Acute Disease', 'Adenoviridae', 'Capsid', 'Capsid Proteins', 'Cell Line', 'Cells, Cultured', 'Genetic Therapy', 'Genetic Vectors', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Heparin', 'Heparitin Sulfate', 'Humans', 'Interleukin-3', 'Leukemia, Myeloid', 'Stem Cell Factor', 'Transfection', 'beta-Galactosidase... | 10,435,081 | [['C23.550.291.125'], ['B04.280.030'], ['A21.249.500.250'], ['D12.776.964.970.600.550'], ['A11.251.210'], ['A11.251'], ['E02.095.301', 'E05.393.420.301'], ['G05.360.337'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D23.529.374.410.240.375'], ['D09.698.373.400'], ['D09.698.373... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Idealizing parenthood to rationalize parental investments. | Although raising children has largely negative effects on parents' emotional well-being, parenthood is often idealized as a uniquely emotionally rewarding role. We tested the hypothesis that belief in myths idealizing parenthood helps parents cope with the dissonance aroused by the high financial cost of raising childr... | ['Adaptation, Psychological', 'Adult', 'Child', 'Economics', 'Emotions', 'Female', 'Humans', 'Male', 'Parent-Child Relations', 'Parenting', 'Parents', 'Personal Satisfaction', 'Rationalization', 'Stress, Psychological'] | 21,245,495 | [['F01.058'], ['M01.060.116'], ['M01.060.406'], ['I01.261', 'N03.219'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290'], ['F01.829.263.370.310'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['F01.145.677'], ['F01.393.746'], ['F01.145.126.990', 'F02.830.900']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial. | BACKGROUND: Depression in older people may have a prevalence as high as 20%, and is associated with physical co-morbidities, loss, and loneliness. It is associated with poorer health outcomes and reduced quality of life, and is under-diagnosed and under-treated. Older people may find it difficult to speak to their GPs ... | ['Aged', 'Aged, 80 and over', 'Attitude of Health Personnel', 'Attitude to Health', 'Case Managers', 'Cooperative Behavior', 'Depressive Disorder, Major', 'Female', 'General Practice', 'General Practitioners', 'Humans', 'Male', 'Mental Health Services', 'Patient Acceptance of Health Care', 'Patient Health Questionnaire... | 30,021,506 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.100.050', 'N05.300.100'], ['F01.100.150', 'N05.300.150'], ['M01.526.070.245', 'M01.526.485.215', 'N02.360.215'], ['F01.145.813.115'], ['F03.600.300.375'], ['H02.403.340'], ['M01.526.485.810.485', 'N02.360.810.485'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
New crosstalk between probiotics Lactobacillus plantarum and Bacillus subtilis. | It was reported that oral administration of Bacillus favored the growth of Lactobacillus in the intestinal tract. Here, this phenomenon was confirmed by co-cultivation of Bacillus subtilis 168 and Lactobacillus plantarum SDMCC050204-pL157 in vitro. To explain the possible molecular mechanisms, B. subtilis 168 cells wer... | ['Bacillus subtilis', 'Catalase', 'Heme', 'Hydrogen Peroxide', 'Intestines', 'Lactobacillus plantarum', 'Microbial Interactions', 'Probiotics', 'Reactive Oxygen Species'] | 31,511,589 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D08.811.682.732.332'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['D01.248.497.158.685.750.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Survey of tick infestation in small ruminants of Miesso district, West Harergie, Oromia Region, Ethiopia. | A survey was conducted to identify tick species and determine the prevalence of tick infestation in small ruminants of Miesso District, West Harergie Zone. Collection and identification of the ticks were undertaken from November 2007 to April 2008. All visible individual adult ticks were collected from the body of 328 ... | ['Animals', 'Ethiopia', 'Goat Diseases', 'Goats', 'Prevalence', 'Sheep', 'Sheep Diseases', 'Tick Infestations'] | 19,082,757 | [['B01.050'], ['Z01.058.290.120.310'], ['C22.405'], ['B01.050.150.900.649.313.500.380.513'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['B01.050.150.900.649.313.500.380.791'], ['C22.836'], ['C01.610.858.211.857']] | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Development of phyllanthin-loaded self-microemulsifying drug delivery system for oral bioavailability enhancement. | Phyllanthin, a poorly water-soluble herbal active component from Phyllanthus amarus, exhibited a low oral bioavailability. This study aims at formulating self-microemulsifying drug delivery systems (SMEDDS) containing phyllanthin and evaluating their in-vitro and in-vivo performances. Excipient screening was carried ou... | ['Administration, Oral', 'Animals', 'Biological Availability', 'Chemistry, Pharmaceutical', 'Drug Delivery Systems', 'Drug Stability', 'Emulsions', 'Hydrogen-Ion Concentration', 'Lignans', 'Male', 'Microscopy, Electron, Scanning', 'Phyllanthus', 'Rats', 'Rats, Sprague-Dawley', 'Solubility', 'Viscosity'] | 24,237,327 | [['E02.319.267.100'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['H01.158.703.007', 'H01.181.466'], ['E02.319.300'], ['E05.916.330'], ['D20.280.260', 'D26.255.165.260'], ['G02.300'], ['D02.455.426.559.389.140.450'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['B01.650.940.800.575.912.250.859.797.438.622'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Construction of multi-purpose vectors, pCNS and pCNS-D2, are suitable for collection and functional study of large-scale cDNAs. | To efficiently perform collection and functional studies of large-scale cDNAs, we constructed multi-functional cDNA vectors for efficient full-length cDNA cloning, direct sequencing, easy screening, and the expression of cDNA in vitro and in vivo without subcloning the cDNA into other vectors. The constructed vectors, ... | ['Animals', 'Base Sequence', 'Cell Line, Tumor', 'DNA Primers', 'DNA, Complementary', 'Gene Expression', 'Gene Library', 'Genetic Vectors', 'Humans', 'Luciferases', 'Molecular Sequence Data', 'Peptide Elongation Factor 1', 'Sequence Analysis, DNA'] | 15,109,828 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.190', 'A11.251.860.180'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.297'], ['G05.360.325'], ['G05.360.337'], ['B01.050.150.900.649... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Gene for alpha 2(I) collagen is on mouse chromosome 6 not 16. | Collagen is the most abundant protein in the animal world and a principal component, of the extracellular matrix of tissues. Type I collagen is composed of two alpha 1 chains and one alpha 2 chain. The human alpha 2(I) locus (COL1A2) has been assigned to human chromosome 7q21.3-q22.1. Here, we report the mapping of its... | ['Animals', 'Blotting, Southern', 'Chromosome Mapping', 'Collagen', 'Genes', 'Hybrid Cells', 'Mice'] | 2,781,418 | [['B01.050'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.393.183'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G05.360.340.024.340'], ['A11.251.600'], ['B01.050.150.900.649.313.992.635.505.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mesenchymal chondrosarcoma in a young German shepherd dog. | An 18-month-old, entire male German shepherd dog was presented with signs indicative of a caudal abdominal space-occupying mass. A needle-core biopsy of this mass failed to establish a definitive diagnosis, but identified a prominent round-cell component. The dog's condition worsened and euthanasia was performed on hum... | ['Animals', 'Biopsy, Needle', 'Bone Neoplasms', 'Chondrosarcoma, Mesenchymal', 'Dog Diseases', 'Dogs', 'Male'] | 10,516,952 | [['B01.050'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C04.588.149', 'C05.116.231'], ['C04.557.450.565.280.280', 'C04.557.450.795.300.280'], ['C22.268'], ['B01.050.150.900.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease. | Pulmonary hypertension is a common complication of sickle cell disease (SCD) and a risk factor for early death. Hemolysis may participate in its pathogenesis by limiting nitric oxide (NO) bioavailability and producing vasculopathy. We hypothesized that hemoglobin mutations that diminish hemolysis in SCD would influence... | ['Adult', 'Age Distribution', 'Alleles', 'Anemia, Sickle Cell', 'Chromatography, High Pressure Liquid', 'Chromosomes, Human, Pair 11', 'Cohort Studies', 'False Positive Reactions', 'Female', 'Genetic Markers', 'Genetic Predisposition to Disease', 'Haplotypes', 'Hemoglobins', 'Humans', 'Hypertension, Pulmonary', 'Male',... | 17,724,704 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['G05.360.340.024.340.030'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['E05.196.181.400.300'], ['A11.284.187.520.300.325.355', 'G05.360.162.520.300.325.355'], ['E05.318.372.500.750', 'N05.715.360.330.50... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The relation between frontal EEG asymmetry and the risk for anxiety and depression. | Frontal asymmetry of EEG alpha power (FA) may index the risk for anxiety and depression. Evidence linking FA to the underlying biological mechanisms is scarce. This is unfortunate because FA has potential as a biological marker to support gene finding in anxiety and depression. We examined the heritability of FA in 732... | ['Adult', 'Anxiety Disorders', 'Depressive Disorder', 'Electroencephalography', 'Female', 'Frontal Lobe', 'Functional Laterality', 'Humans', 'Male', 'Middle Aged', 'Personality Inventory', 'Phenotype', 'Risk Factors', 'Surveys and Questionnaires', 'Twins'] | 16,875,773 | [['M01.060.116'], ['F03.080'], ['F03.600.300'], ['E01.370.376.300', 'E01.370.405.245'], ['A08.186.211.200.885.287.500.270'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.647.513'], ['G05.695'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Laparoscopy for suspected appendicitis in children: May a macroscopically normal appendix be left in situ? | BACKGROUND/PURPOSE: An appendix which appears macroscopically normal is found in 10%-20% of laparoscopic explorations for suspected appendicitis. The appropriate surgical strategy for these cases is a matter of debate. We analysed a consecutive series of children in whom an inconspicuous appendix was left in situ.MATER... | ['Adolescent', 'Appendicitis', 'Appendix', 'Child', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Treatment Outcome'] | 19,347,808 | [['M01.060.057'], ['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['A03.556.124.526.209.290', 'A03.556.249.249.209.290'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Metallothionein gene regulation in the preimplantation rabbit blastocyst. | Expression of metallothionein (MT) genes in the preimplantation rabbit blastocyst was analysed by determination of the levels of MT mRNA and relative rates of MT synthesis. MT was found to be constitutively expressed at low levels in the blastocyst. Exposure of the day-6 blastocyst to zinc ions in vitro rapidly increas... | ['Animals', 'Blastocyst', 'Cadmium', 'Chromatography, Ion Exchange', 'Embryonic Development', 'Female', 'Gene Expression Regulation', 'Metallothionein', 'Pregnancy', 'Rabbits', 'Zinc'] | 3,652,981 | [['B01.050'], ['A16.254.500'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['E05.196.181.400.383'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['G05.308'], ['D12.776.556.670'], ['G08.686.784.769'], ['B01.050.150.900.649.313.968.700'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Giardia intestinalis in patients with nonulcer dyspepsia. | BACKGROUND AND STUDY AIMS: Giardiasis may present with dyspeptic symptoms that may mimic other gastrointestinal and/or biliary disorders. The objective of this study was to determine the prevalence of giardiasis in stool and duodenal aspirate of patients with NUD, assess symptomatic benefit of therapy, and compare the ... | ['Adolescent', 'Adult', 'Antiprotozoal Agents', 'Drug Therapy, Combination', 'Duodenum', 'Dyspepsia', 'Enzyme-Linked Immunosorbent Assay', 'Feces', 'Female', 'Giardia lamblia', 'Giardiasis', 'Humans', 'Male', 'Microscopy', 'Middle Aged', 'Omeprazole', 'Proton Pump Inhibitors', 'Quality of Life', 'Severity of Illness In... | 24,206,742 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.250.100'], ['E02.319.310'], ['A03.556.124.684.124', 'A03.556.875.249'], ['C23.888.821.236'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A12.459'], ['B01.237.385.400'], ['C01.610.432.481', 'C0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Is sex of fetus associated with duration of labor in nulliparas? | In a post facto study to examine whether sex of fetus was related to duration of nulliparas' labor 30 nulliparous (had not given birth previously) women who delivered boys and 30 others who delivered girls were matched according to the criteria that they were nulliparous, received an epidural for analgesia during labor... | ['Female', 'Humans', 'Infant, Newborn', 'Labor, Obstetric', 'Male', 'Pregnancy', 'Sex Characteristics', 'Time Factors'] | 9,400,076 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769.326'], ['G08.686.784.769'], ['G08.686.815'], ['G01.910.857']] | ['Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reach distance and safety standards. | The reach of British males of 99th percentile stature over different height barriers was determined to establish reach distances for a proposed Comit? Europeen de Normalisation (CEN) standard. The distances recorded are considerably in excess of those given in the draft West German standard DIN 31001 1984, and those gi... | ['Adult', 'Body Height', 'Equipment Design', 'Equipment Safety', 'Humans', 'Male', 'Reference Standards', 'United Kingdom'] | 2,806,230 | [['M01.060.116'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['E05.320'], ['E05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.808'], ['Z01.542.363']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives. | A series of 4-hydroxy-3-quinolinecarboxylic acid derivatives (6) and 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid derivatives (7) were designed and synthesized as 5-HT3 receptor antagonists. Molecular modeling studies suggested that the 3-carbonyl moiety in 6 was almost coplanar to the plane of an aromatic ri... | ['Animals', 'Antiemetics', 'Bridged Bicyclo Compounds', 'Bridged Bicyclo Compounds, Heterocyclic', 'Cisplatin', 'Dogs', 'Guinea Pigs', 'Heart Rate', 'Hydrogen Bonding', 'Magnetic Resonance Spectroscopy', 'Male', 'Mice', 'Models, Molecular', 'Molecular Structure', 'Ondansetron', 'Quinolines', 'Quipazine', 'Rats', 'Rats,... | 8,496,941 | [['B01.050'], ['D27.505.696.663.050.030', 'D27.505.954.427.095', 'D27.505.954.483.200'], ['D02.455.426.100.080', 'D04.075.080'], ['D03.605.084'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.992.550'], ['E01.370.600.875.500', 'G09.330.380.500'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of large cryptic plasmids in Clostridioides (Clostridium) difficile. | Clostridioides (Clostridium) difficile is a major bacterial pathogen of both humans and animals. Several species of pathogenic clostridia are known to harbour large plasmids with combinations of virulence, antibiotic resistance and metabolism determinants. Small cryptic plasmids have been previously identified in C. di... | ['Bacterial Typing Techniques', 'Bacteriophages', 'Clostridioides difficile', 'DNA Replication', 'Genetic Variation', 'Open Reading Frames', 'Phylogeny', 'Plasmids', 'Recombination, Genetic', 'Sequence Analysis, DNA', 'Virulence', 'Virulence Factors'] | 29,702,124 | [['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['B04.123'], ['B03.353.625.657.500'], ['G02.111.225', 'G05.226'], ['G05.365'], ['G05.360.335.760.640', 'G05.360.340.024.340.137.650'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G05.360.600'], ['G05.728'], ['E05.393.760.700'], ['G06.930'], ['D23.946.896']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Distraction of eye-hand coordination varies with working memory capacity. | The authors present a study of the relationship between individual variation in working memory capacity (WMC) and visually guided hand control in the face of visual distraction. WMC was assessed with the automated operation span task. Hand control was measured by requesting participants to track a visual target with a ... | ['Adolescent', 'Adult', 'Attention', 'Female', 'Humans', 'Individuality', 'Male', 'Memory, Short-Term', 'Photic Stimulation', 'Psychomotor Performance'] | 23,406,167 | [['M01.060.057'], ['M01.060.116'], ['F02.830.104.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.488'], ['F02.463.425.540.407'], ['E05.723.729'], ['F02.808', 'G11.427.700', 'G11.561.660']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Implicit alcohol cognitions in risky drinking nicotine users with and without co-morbid major depressive disorder. | OBJECTIVE: Alcohol consumption, nicotine use, and major depressive disorder (MDD) are highly co-morbid. The negative reinforcement model of addiction would suggest that smokers may consume alcohol to relieve negative affective symptoms, such as those associated with MDD and withdrawal from nicotine. Over time, these be... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Analysis of Variance', 'Association', 'Comorbidity', 'Depressive Disorder, Major', 'Female', 'Humans', 'Linear Models', 'Male', 'Motivation', 'Neuropsychological Tests', 'Nicotine', 'Risk-Taking', 'Set, Psychology', 'Substance Withdrawal Syndrome', 'Surveys and Questionnaire... | 24,531,633 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.463.425.069', 'F04.754.720.346'], ['N05.715.350.225', 'N06.850.490.687'], ['F03.600.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Knee Society Award Papers Are Highly Cited Works. | BACKGROUND: Since 1993, The Knee Society has presented three annual awards recognizing the best research papers presented at the annual meetings. To date, no quantitative evaluation has determined whether the selection process identifies the most meritorious papers based on subsequent citations. In the absence of valid... | ['Awards and Prizes', 'Bibliometrics', 'Biomedical Research', 'Humans', 'Orthopedic Procedures', 'Orthopedics', 'Periodicals as Topic', 'Societies, Medical', 'Time Factors'] | 26,013,147 | [['K01.150'], ['L01.178.682.099.325', 'L01.453.183.291'], ['H01.770.644.145'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.718', 'E04.555'], ['H02.403.810.494'], ['L01.178.682.829.678'], ['N03.540.828.589'], ['G01.910.857']] | ['Humanities [K]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Deanol and methylphenidate in minimal brain dysfunction. | Deanol, a putative acetylcholine precursor, has been used as a treatment for childhood hyperactivity for years. Efficacy has not been satisfactorily established, however. Seventy-four children referred for problems with learning, including many with hyperactivity, were screened for neurological or psychiatric illness, ... | ['Analysis of Variance', 'Attention Deficit Disorder with Hyperactivity', 'Child', 'Clinical Trials as Topic', 'Deanol', 'Electroencephalography', 'Ethanolamines', 'Female', 'Humans', 'Learning Disabilities', 'Male', 'Methylphenidate', 'Placebos', 'Psychological Tests', 'Psychometrics', 'Reaction Time'] | 1,092,513 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F03.625.094.150'], ['M01.060.406'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D02.033.100.291.274', 'D02.092.063.291.274'], ['E01.370.376.300', 'E01.370.405.245'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A MADS box protein interacts with a mating-type protein and is required for fruiting body development in the homothallic ascomycete Sordaria macrospora. | MADS box transcription factors control diverse developmental processes in plants, metazoans, and fungi. To analyze the involvement of MADS box proteins in fruiting body development of filamentous ascomycetes, we isolated the mcm1 gene from the homothallic ascomycete Sordaria macrospora, which encodes a putative homolog... | ['Amino Acid Sequence', 'Base Sequence', 'Cell Nucleus', 'Cloning, Molecular', 'Fruiting Bodies, Fungal', 'Genes, Mating Type, Fungal', 'MADS Domain Proteins', 'Minichromosome Maintenance 1 Protein', 'Molecular Sequence Data', 'Mutation', 'Phenotype', 'Sequence Deletion', 'Sequence Homology, Amino Acid', 'Sordariales',... | 16,835,449 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E05.393.220'], ['A19.374'], ['G05.360.340.024.340.364.500.089', 'G05.360.340.358.024.500.089', 'G05.360.340.358.365.500.089'], ['D12.776.260.400.249', 'D12.776.93... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Preliminary crystallographic study of an acidic phospholipase A2 from Ophiophagus hannah (king cobra). | An acidic phospholipase A(2) (OH APLA(2)-II) with an isoelectric point (pI) of 4.0 was recently isolated from Ophiophagus hannah (king cobra) from Guangxi province, China. Comparison of this enzyme to a previously reported homologous phospholipase A(2) from the same venom shows that it lacks toxicity and exhibits a gre... | ['Animals', 'China', 'Crystallography, X-Ray', 'Elapid Venoms', 'Elapidae', 'Kinetics', 'Phospholipases A', 'Phospholipases A2'] | 12,351,830 | [['B01.050'], ['Z01.252.474.164'], ['E05.196.309.742.225'], ['D20.888.850.325', 'D23.946.833.850.325'], ['B01.050.150.900.833.672.125.875'], ['G01.374.661', 'G02.111.490'], ['D08.811.277.352.100.680.750'], ['D08.811.277.352.100.680.750.937']] | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
NAD(+)-independent aldehyde oxidase catalyzes cofactor balanced 3-hydroxypropionic acid production in Klebsiella pneumoniae. | The limiting step for biosynthesis of 3-hydroxypropionic acid (3-HP) in Klebsiella pneumoniae is the conversion of 3-hydroxypropionaldehyde (3-HPA) to 3-HP. This reaction is catalyzed by aldehyde dehydrogenase (ALDH) with NAD(+) as a cofactor. Although NAD(+)-dependent ALDH overexpression facilitates 3-HP biosynthesis,... | ['Aldehyde Dehydrogenase', 'Aldehyde Oxidase', 'Biomass', 'Bioreactors', 'Biotechnology', 'Klebsiella pneumoniae', 'Lactic Acid', 'NAD', 'Pseudomonas', 'Recombinant Proteins'] | 24,980,850 | [['D08.811.682.657.163.249'], ['D08.811.682.657.163.311'], ['G16.500.275.157.100', 'N06.230.124.100'], ['E07.115', 'J01.897.120.115'], ['H01.158.550', 'J01.897.120'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['D02.241.511.459.450'], ['D03.633.100.759.646.138.694', 'D08.211.589', 'D13.695.667.138.694', 'D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury. | Spinal cord injury (SCI) leads to an inflammatory response that generates substantial secondary damage within the tissue besides the primary damage. Leukotrienes are biologically active 5-lipoxygenase products of arachidonic acid metabolism that are involved in the mediation of various inflammatory disorders including ... | ['Acetates', 'Animals', 'Behavior, Animal', 'Caspase 3', 'Down-Regulation', 'Glutathione', 'Interleukin-1beta', 'Leukotriene Antagonists', 'Leukotriene B4', 'Lipid Peroxidation', 'Luminescent Measurements', 'Luminol', 'Malondialdehyde', 'Neutrophil Infiltration', 'Neutrophils', 'Oxidative Stress', 'Peroxidase', 'Quinol... | 22,986,158 | [['D02.241.081.018', 'D10.251.400.045'], ['B01.050'], ['F01.145.113'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D12.644.456.448'], ['D12.644.276.374.465.010.600', 'D1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. | To understand the role of the colonic extracellular calcium-sensing receptor (CaSR) in calcium chemoprotection against colon cancer, we activated the CaSR with 5 mM Ca(2+) on HT-29 cells, an adenocarcinoma cell line. High Ca(2+) stimulated the upregulation (as assessed by RT-PCR) and the secretion of Wnt5a (assessed by... | ['Adenocarcinoma', 'Adenomatous Polyposis Coli Protein', 'Calcium', 'Calcium Signaling', 'Cell Line, Tumor', 'Cells, Cultured', 'Colonic Neoplasms', 'Humans', 'Nuclear Proteins', 'Proto-Oncogene Proteins', 'Receptor Tyrosine Kinase-like Orphan Receptors', 'Receptors, Calcium-Sensing', 'Receptors, Cell Surface', 'Ubiqui... | 17,463,182 | [['C04.557.470.200.025'], ['D05.500.117.249', 'D12.776.220.040', 'D12.776.476.081.249', 'D12.776.624.776.010'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['C04.588.274.476.411.307.180', 'C06.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Older adults with acquired brain injury: outcomes after inpatient rehabilitation. | This study examined a population-based profile of older adults with acquired brain injury, and their functional outcomes, in in-patient rehabilitation. Older adults aged 65 and older admitted to in-patient rehabilitation from acute care with traumatic brain injury (TBI) (n = 1214) or non-traumatic brain injury (nTBI) (... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Brain Diseases', 'Brain Injuries', 'Brain Neoplasms', 'Canada', 'Cohort Studies', 'Female', 'Hospitalization', 'Humans', 'Hypoxia, Brain', 'Length of Stay', 'Male', 'Retrospective Studies', 'Treatment Outcome'] | 23,915,910 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['Z01.107.567.176'], ['E05.318.372.500.750', 'N05.715.360.33... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Defining a therapeutic window for laser irradiation (810 nm) applied to the inguinal region to ameliorate diabetes in diabetic mice. | OBJECTIVE: The purpose of this study was to determine a therapeutic window of antidiabetic effect by laser irradiating the left inguinal region of diabetic mice (810 nm 20.4 and 40.8 J/cm(2)) for 7 days.BACKGROUND DATA: Irradiation of 810 nm 10.2 J/cm(2) to the left inguinal region of diabetic mice for 7 days significa... | ['Animals', 'Blood Glucose', 'Diabetes Mellitus, Experimental', 'Drinking', 'Fructosamine', 'Inguinal Canal', 'Low-Level Light Therapy', 'Mice'] | 25,102,241 | [['B01.050'], ['D09.947.875.359.448.500'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G07.203.650.283.249', 'G10.261.330.249'], ['D09.067.342.300'], ['A01.923.047.412'], ['E02.594.540', 'E02.774.500'], ['B01.050.150.900.649.313.992.635.505.500']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Using perceptual illusions for redirected walking. | Redirected walking (RDW) gives users the ability to explore a virtual world by walking in a confined physical space. It inconspicuously guides them on a physical path that might differ from the path they perceive in the virtual world. Exploiting three motion illusions-the change-blindness illusion, the four-stroke moti... | ['Computer Graphics', 'Humans', 'Motion', 'Space Perception', 'User-Computer Interface', 'Walking'] | 24,807,877 | [['L01.224.108', 'L01.296.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.482'], ['F02.463.593.778'], ['L01.224.900.910'], ['G11.427.410.568.900', 'G11.427.410.698.277.937', 'I03.350.937', 'I03.450.642.845.940']] | ['Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
The heart's exposure to radiation increases the risk of cardiac toxicity after chemoradiotherapy for superficial esophageal cancer: a retrospective cohort study. | BACKGROUND: Chemoradiotherapy effectively treats superficial esophageal cancer and is optimal to preserve organs. However, late toxicity, particularly in cardiac diseases, obstructs clinical outcomes. We revealed the risk factors for cardiac event development post-chemoradiotherapy.METHODS: Data from 80 patients who we... | ['Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Atrial Fibrillation', 'Cardiotoxicity', 'Chemoradiotherapy', 'Cisplatin', 'Cohort Studies', 'Death, Sudden, Cardiac', 'Disease-Free Survival', 'Esophageal Neoplasms', 'Esophageal Squamous Cell Carcinoma', 'Female', 'Fluorouracil', 'Humans', 'Male', 'Middle Age... | 30,832,605 | [['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C14.280.067.198', 'C23.550.073.198'], ['C14.280.260', 'C23.550.161', 'C25.100.389', 'C26.733.266', 'G01.750.748.500.266'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E05.318.372.500.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila. | The Drosophila core circadian circuit contains distinct groups of interacting neurons that give rise to diurnal sleep-wake patterns. Previous work showed that a subset of dorsal neurons 1 (DN1s) are sleep-promoting through their inhibition of activity-promoting circadian pacemakers. Here we show that these anterior-pro... | ['Animals', 'Arousal', 'Brain', 'Brain Chemistry', 'Circadian Rhythm', 'Drosophila melanogaster', 'Locomotion', 'Male', 'Nerve Net', 'Optogenetics', 'Sleep', 'Wakefulness'] | 30,269,992 | [['B01.050'], ['F02.830.104', 'G11.561.035'], ['A08.186.211'], ['G02.111.150', 'G03.185'], ['G07.180.562.190'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G07.568.500', 'G11.427.410.568'], ['A08.511'], ['E05.393.667'], ['F02.830.855', 'G11.561.803'], ['F02.830.104.821', 'G11.561.035.738']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Negative regulation of CD4 gene expression by a HES-1-c-Myb complex. | Expression of the CD4 gene is tightly controlled throughout thymopoiesis. The downregulation of CD4 gene expression in CD4(-) CD8(-) and CD4(-) CD8(+) T lymphocytes is controlled by a transcriptional silencer located in the first intron of the CD4 locus. Here, we determine that the c-Myb transcription factor binds to a... | ['Basic Helix-Loop-Helix Transcription Factors', 'Binding Sites', 'CD4 Antigens', 'Cell Line', 'Epitopes, B-Lymphocyte', 'Gene Expression Regulation', 'Gene Silencing', 'Helix-Loop-Helix Motifs', 'Homeodomain Proteins', 'Humans', 'Mutagenesis', 'Proto-Oncogene Proteins c-myb', 'Repressor Proteins', 'Transcription Facto... | 11,287,612 | [['D12.776.260.103', 'D12.776.930.125'], ['G02.111.570.120'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['A11.251.210'], ['D23.050.550.395'], ['G05.308'], ['G05.308.203.374'], ['G02.111.570.820.709.275.500.360'], ['D12.776.260.400'], ['B01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
First report of molecular diagnosis of Tunisian hemophiliacs A: identification of 8 novel causative mutations. | INTRODUCTION: Hemophilia A is an X linked recessive hemorrhagic disorder caused by mutations in the F8 gene that lead to qualitative and/or quantitative deficiencies of coagulation factor VIII (FVIII). Molecular diagnosis of hemophilia A is challenging because of the high number of different causative mutations that ar... | ['Adolescent', 'Adult', 'Blotting, Southern', 'Child', 'Child, Preschool', 'Computational Biology', 'DNA Mutational Analysis', 'Databases, Genetic', 'Exons', 'Factor VIII', 'Genetic Predisposition to Disease', 'Hemophilia A', 'Humans', 'Introns', 'Models, Molecular', 'Mutagenesis, Insertional', 'Mutation', 'Mutation, M... | 22,883,072 | [['M01.060.057'], ['M01.060.116'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['M01.060.406'], ['M01.060.406.448'], ['H01.158.273.180', 'L01.313.124'], ['E05.393.760.700.300'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.360.340.024.340.137.232'], ['D12.776.124.125.350', 'D12.776.811.2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Self-Acceptance and Interdependence Promote Longevity: Evidence From a 20-year Prospective Cohort Study. | We explored psychosocial pathways to longevity, specifically, the association between psychological well-being and mortality in a 20-year prospective cohort study of 7626 participants. As hypothesized, high self-acceptance and interdependence were associated with decreased mortality risk, controlling for other psycholo... | ['Aging', 'Female', 'Humans', 'Longevity', 'Male', 'Personality', 'Prospective Studies'] | 32,824,658 | [['G07.345.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.345.124.519', 'G07.540'], ['F01.752'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Endobiliary stents for palliation in patients with malignant obstructive jaundice. | BACKGROUND: Endobiliary drainage for malignant obstructive jaundice presents a viable palliative alternative. Its role and efficacy depend on factors related to the stent, procedure, and patient.GOALS: To review the evidence in the literature in which settings plastic or metal stents are cost-effective, and whether adj... | ['Bile Ducts', 'Cost-Benefit Analysis', 'Female', 'Follow-Up Studies', 'Humans', 'Jaundice, Obstructive', 'Male', 'Palliative Care', 'Prosthesis Implantation', 'Retrospective Studies', 'Review Literature as Topic', 'Risk Factors', 'Sex Factors', 'Stents', 'Survival Rate', 'Treatment Outcome'] | 15,815,210 | [['A03.159.183'], ['N03.219.151.125'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.429.500.755', 'C23.888.885.375.500'], ['E02.760.666', 'N02.421.585.666'], ['E04.650'], ['E05.318.372.500.500.500', 'E05.318.372.500... | ['Anatomy [A]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Restriction of dietary glycotoxins reduces excessive advanced glycation end products in renal failure patients. | Advanced glycation endproduct (AGE) levels are elevated in renal failure patients and may contribute to the excessive cardiovascular disease in this population. Diet-derived AGE are major contributors to the total body AGE pool. It was postulated that a reduction in dietary AGE intake might impact on the high circulati... | ['Adult', 'Diet', 'Glycation End Products, Advanced', 'Humans', 'Kidney Failure, Chronic', 'Peritoneal Dialysis', 'Regression Analysis'] | 12,595,509 | [['M01.060.116'], ['G07.203.650.240'], ['D12.776.643.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E02.870.300.650', 'E02.912.800.650'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A retrospective analysis of alcohol in medico-legal autopsied deaths in Pretoria over a 1 year period. | The misuse of alcohol has a particularly detrimental effect and is one of the most significant public health problems in South Africa and it also has an impact on the criminal justice system with evidence of association between high levels of alcohol and risk-taking behaviour, committing crimes, or being a victim of cr... | ['Accidents', 'Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Alcohol Drinking', 'Blood Alcohol Content', 'Cause of Death', 'Child', 'Child, Preschool', 'Continental Population Groups', 'Driving Under the Influence', 'Female', 'Homicide', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies'... | 25,447,167 | [['N06.850.135'], ['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.317.269'], ['D02.033.375.135'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M01.060.4... | ['Health Care [N]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Evaluation of a real-time quantitative polymerase chain reaction assay for detection and quantitation of virulent Rhodococcus equi. | OBJECTIVE: To evaluate a real-time quantitative polymerase chain reaction (QPCR) assay in the detection and quantitation of virulent Rhodococcus equi.SAMPLE POPULATION: 1 virulent, 2 intermediately virulent, and 2 avirulent strains of R. equi and 16 isolates of bacteria genetically related to R. equi.PROCEDURE: The QPC... | ['Actinomycetales Infections', 'Animals', 'Bronchoalveolar Lavage Fluid', 'DNA, Bacterial', 'Horse Diseases', 'Horses', 'Polymerase Chain Reaction', 'Rhodococcus equi', 'Sensitivity and Specificity', 'Virulence'] | 15,940,818 | [['C01.150.252.410.040'], ['B01.050'], ['E05.927.100.500'], ['D13.444.308.212'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['E05.393.620.500'], ['B03.510.024.981.775.700'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of chromium histidinate on renal function, oxidative stress, and heat-shock proteins in fat-fed and streptozotocin-treated rats. | OBJECTIVE: Chromium is an essential element for carbohydrate, fat, and protein metabolism. The therapeutic potential of chromium histidinate (CrHis) in the treatment of diabetes has been elucidated. The present study investigated the effects of CrHis on serum parameters of renal function, on oxidative stress markers (m... | ['Animals', 'Chaperonin 60', 'Diabetes Mellitus, Experimental', 'Diabetes Mellitus, Type 2', 'Diabetic Nephropathies', 'Dietary Fats', 'Dinoprost', 'HSP70 Heat-Shock Proteins', 'Heat-Shock Proteins', 'Histidine', 'Kidney', 'Lipid Peroxidation', 'Male', 'Malondialdehyde', 'Organometallic Compounds', 'Oxidative Stress', ... | 19,616,452 | [['B01.050'], ['D08.811.277.040.025.142.500.500', 'D12.776.580.216.210.590.750'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C18.452.394.750.149', 'C19.246.300'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D10.251.355.255.550.400... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Agenesis of the pulmonary artery: an unusual cause of dyspnea in pregnancy. | A pregnancy complicated by dyspnea was associated with agenesis of the right pulmonary artery. The clinical characteristics of the agenesis of the pulmonary artery along with the differential diagnosis from pulmonary embolus are discussed. | ['Adult', 'Diagnosis, Differential', 'Dyspnea', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Pulmonary Artery', 'Pulmonary Embolism', 'Radiography'] | 3,337,167 | [['M01.060.116'], ['E01.171'], ['C08.618.326', 'C23.888.852.371'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C13.703.634', 'C14.583'], ['A07.015.114.715'], ['C08.381.746', 'C14.907.355.350.700'], ['E01.370.350.700']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis. | The platelet-derived growth factor receptor alpha-subunit (PDGFR alpha) is the form of the PDGF receptor that is required for binding of PDGF A-chain. Expression of PDGFR alpha within the early embryo is first detected as the mesoderm forms, and remains characteristic of many mesodermal derivatives during later develop... | ['Animals', 'Blotting, Northern', 'Central Nervous System', 'Gene Expression', 'Gene Expression Regulation', 'Mesoderm', 'Mice', 'Mice, Inbred Strains', 'Microscopy, Fluorescence', 'Molecular Probe Techniques', 'Mutation', 'Nucleic Acid Hybridization', 'Receptors, Cell Surface', 'Receptors, Platelet-Derived Growth Fact... | 1,322,269 | [['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A08.186'], ['G05.297'], ['G05.308'], ['A16.504.660'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['E01.370.350.515.458', 'E05.595.458'], ['E05.601'], ['G05.365.590'], ['E0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differences in surface expression of NspA among Neisseria meningitidis group B strains. | NspA is a highly conserved membrane protein that is reported to elicit protective antibody responses against Neisseria meningitidis serogroups A, B and C in mice (D. Martin, N. Cadieux, J. Hanel, and B. R. Brodeur, J. Exp. Med. 185:1173-1183, 1997). To investigate the vaccine potential of NspA, we produced mouse anti-r... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Monoclonal', 'Antigens, Bacterial', 'Bacterial Outer Membrane Proteins', 'Bacterial Vaccines', 'Female', 'Immune Sera', 'Mice', 'Molecular Sequence Data', 'Neisseria meningitidis', 'Polysaccharides, Bacterial', 'Rats', 'Rats, Wistar'] | 10,531,214 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.161'], ['D12.776.097.120', 'D12.776.543.100'], ['D20.215.894.135'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D1... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Age-related changes in the function of the pituitary-gonadal axis in a sterile male rat mutant (hd/hd). | Testicular growth is depressed in the genetically sterile male rat (hd/hd) relative to its LE phenotype littermates (by 50% and 73% at 27 and 90 days of age, respectively). Within the hd/hd testis, both the tubular and seminiferous tubule tissues are affected by the mutation. In addition, there is significantly less ge... | ['Aging', 'Androgen-Binding Protein', 'Animals', 'Cell Division', 'Chorionic Gonadotropin', 'Follicle Stimulating Hormone', 'Gonadotropins', 'Infertility, Male', 'Leydig Cells', 'Luteinizing Hormone', 'Male', 'Organ Size', 'Pituitary Gland', 'Rats', 'Rats, Mutant Strains', 'Seminiferous Tubules', 'Sertoli Cells', 'Sper... | 1,908,710 | [['G07.345.124'], ['D12.776.157.065'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['D06.472.699... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stability assessment of gadolinium complexes by P-31 and H-1 relaxometry. | Longitudinal P-31 relaxation rate enhancements of phosphate groups have been measured at pH 7-7.2 and 310 degrees K on aqueous solutions containing adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi) and some lanthanide complexes (Gd-DOTA, Gd-HPDO3A, Gd-DO3A, Gd-DTPA, Gd-DTPA-BMA). The macrocy... | ['Contrast Media', 'Drug Stability', 'Gadolinium', 'Gadolinium DTPA', 'Heterocyclic Compounds', 'Organometallic Compounds', 'Pentetic Acid'] | 8,208,120 | [['D27.505.259.500', 'D27.720.259'], ['E05.916.330'], ['D01.268.558.362.484', 'D01.552.550.399.484'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['D03'], ['D02.691'], ['D02.092.782.590', 'D02.241.081.018.639']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Template matching techniques for electrophysiologic signals: a practical, real-time system for detection of ventricular tachycardia. | Time domain template matching morphology techniques have been proposed for inclusion in implantable cardioverter defibrillators (ICDs) for the detection of ventricular arrhythmias from intraventricular electrograms (IVEGs). However, ICDs have limited battery capacity which necessitate the use of low current drain algor... | ['Algorithms', 'Electric Countershock', 'Electrophysiology', 'Humans', 'Signal Processing, Computer-Assisted', 'Tachycardia'] | 1,643,228 | [['G17.035', 'L01.224.050'], ['E02.331.350'], ['H01.158.344.528', 'H01.158.782.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.800'], ['C14.280.067.845', 'C14.280.123.875', 'C23.550.073.845']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
FTIR study of glyphosate-copper complexes. | Complexes of the herbicide glyphosate (GPS) and the heavy metal Cu were studied by infrared spectroscopy under controlled pH, in order to know the mechanisms involved in the formation of these complexes. In CuGPS(-), the IR spectrum shows participation of the carboxylate and phosphonic moieties of the GPS molecule. The... | ['Copper', 'Freeze Drying', 'Glycine', 'Herbicides', 'Hydrogen-Ion Concentration', 'Spectrophotometry, Infrared', 'Spectroscopy, Fourier Transform Infrared'] | 11,902,933 | [['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E01.370.225.500.620.760.160.260', 'E01.370.225.750.600.760.160.260', 'E02.792.156.260', 'E05.200.500.620.760.160.260', 'E05.200.750.600.760.160.260', 'E05.760.156.260'], ['D12.125.481'], ['D27.720.031.700.366', 'D27.888.723.366'], ['G02.300'], ['E05.196.712.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multilocus sequence analysis provides basis for fast and reliable identification of Vibrio harveyi-related species and reveals previous misidentification of important marine pathogens. | Vibrio harveyi and related bacteria are important pathogens responsible for severe economic losses in the aquaculture industry worldwide. Phenotypic tests and 16S rRNA gene analysis fail to discriminate species within the V. harveyi group because these are phenotypically and genetically nearly identical. This study use... | ['Animals', 'Aquaculture', 'Australia', 'Bacterial Proteins', 'Bacterial Typing Techniques', 'DNA, Bacterial', 'Diagnostic Errors', 'Fish Diseases', 'Molecular Sequence Data', 'Multilocus Sequence Typing', 'Penaeidae', 'Phylogeny', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Species Specificity', 'Vibrio', 'Vibri... | 22,055,753 | [['B01.050'], ['J01.040.168'], ['Z01.639.100', 'Z01.678.100.373'], ['D12.776.097'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['D13.444.308.212'], ['E01.354', 'N02.421.450.280'], ['C22.362'], ['L01.453.245.667'], ['E01.370.225.875.150.125.457.500', 'E05.200.875.150.125.457.500', 'E05.393.542.500', 'E05.393.76... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Primary synovial sarcoma of the parapharyngeal space: a clinicopathologic study of five cases. | We report five cases of primary synovial sarcomas arising in the parapharyngeal space. The patients were all men with a median age of 35 years (range 22 to 41 years). The tumors were non-encapsulated solid masses ranging from 2.0 to 6.6 cm in size. Histologically, three cases were biphasic subtype, and the other two ca... | ['Adult', 'Diagnosis, Differential', 'Fatal Outcome', 'Humans', 'Male', 'Neoplasm Staging', 'Pharyngeal Neoplasms', 'Sarcoma, Synovial', 'Young Adult'] | 22,862,905 | [['M01.060.116'], ['E01.171'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789.625'], ['C04.588.443.665.710', 'C07.550.745', 'C09.647.710', 'C09.775.549'], ['C04.557.450.565.835', 'C04.557.450.79... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Distal biceps brachii tendon anatomy revisited from a surgical perspective. | The distal biceps brachii tendon is commonly susceptible to traumatic injury. This study aimed to describe the morphology of the distal biceps brachii tendon in relation to the commonly used endobutton repair of tendon rupture. The results suggested that the distal tendon is a series of distinct bands of variable numbe... | ['Aged', 'Arm', 'Arm Injuries', 'Female', 'Humans', 'Male', 'Muscle, Skeletal', 'Rupture', 'Tendon Injuries', 'Tendons'] | 19,280,656 | [['M01.060.116.100'], ['A01.378.800.075'], ['C26.088'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['C26.761'], ['C26.874'], ['A02.880']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Apical junction complex protein expression in the canine colon: differential expression of claudin-2 in the colonic mucosa in dogs with idiopathic colitis. | Canine idiopathic lymphocytic-plasmacytic colitis (LPC) is a well-recognized clinical and pathological entity in the dog, associated with altered immune cell populations and cytokine expression profiles. Clinical and experimental data indicate that alterations in the permeability of the intestinal epithelium contribute... | ['Adherens Junctions', 'Animals', 'Cadherins', 'Colitis', 'Colon', 'Dog Diseases', 'Dogs', 'Immunohistochemistry', 'Intestinal Mucosa', 'Membrane Proteins', 'Occludin', 'Phosphoproteins', 'Tight Junctions', 'Zonula Occludens-1 Protein', 'beta Catenin'] | 17,595,339 | [['A11.284.149.165.420.020'], ['B01.050'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['C06.405.205.265', 'C06.405.469.158.188'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.225.500.607.512', 'E01.370.225.750.551... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Progesterone regulation of activating protein-1 transcriptional activity: a possible mechanism of progesterone inhibition of endometrial cancer cell growth. | The uterine endometrium and cancers derived from it are classic models of hormone action: estrogen promotes growth and progesterone inhibits proliferation and results in differentiation. We have now identified a major pathway through which progesterone causes these growth-limiting effects. Ligand-bound progesterone rec... | ['Cell Division', 'Cell Line, Tumor', 'Cyclin D1', 'DNA', 'Endometrial Neoplasms', 'Female', 'Humans', 'Progesterone', 'Promoter Regions, Genetic', 'Proto-Oncogene Proteins c-jun', 'RNA, Messenger', 'Receptors, Progesterone', 'Transcription Factor AP-1', 'Transcription, Genetic', 'Tumor Suppressor Protein p53', 'rho GT... | 14,672,732 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['D13.444.308'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.20... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Autoregulation of capillary pressure and filtration in cat skeletal muscle in states of normal and reduced vascular tone. | The controversial hypothesis that capillary pressure (Pc) is autoregulated in response to arterial pressure (PA) alterations was tested in sympathectomized cat skeletal muscle by studying the relation between Pc and PA under conditions of well preserved vascular tone and reactivity, during papaverine-induced maximal va... | ['Adrenergic beta-Agonists', 'Adrenergic beta-Antagonists', 'Animals', 'Blood Pressure', 'Capillary Permeability', 'Capillary Resistance', 'Cats', 'Homeostasis', 'Hydrostatic Pressure', 'Isoproterenol', 'Muscles', 'Papaverine', 'Vascular Resistance', 'Vasodilation'] | 2,883,809 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G03.143.330', 'G09.330.165'], ['G09.330.380.921.327'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G07.410'], ['G01.374.715.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hydration structure of poly(2-methoxyethyl acrylate): comparison with a 2-methoxyethyl acetate model monomer. | We have previously reported the hydration structure of a poly(2-methoxyethyl acrylate) (PMEA) antithrombogenic material. In the present study, the hydration structure of a 2-methoxyethyl acetate (MEAc) model monomer for PMEA was explored by means of attenuated total reflection infrared (ATR-IR) spectroscopy and differe... | ['Acetates', 'Acrylates', 'Biocompatible Materials', 'Calorimetry, Differential Scanning', 'Freezing', 'Polymers', 'Spectrophotometry, Infrared', 'Water'] | 20,566,058 | [['D02.241.081.018', 'D10.251.400.045'], ['D02.241.081.069'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E05.196.131.310', 'E05.196.370.310'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['D01.045.250.875', '... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Prediction of Visual Field Progression in Patients with Primary Open-Angle Glaucoma, Mainly Including Normal Tension Glaucoma. | An objective method to predict individual visual field progression will contribute to realise personalised medication. The purpose of this study was to establish a predictive formula for glaucomatous visual field progression in patients with Primary open-angle glaucoma, mainly including normal tension glaucoma. This st... | ['Aged', 'Disease Progression', 'Female', 'Glaucoma, Open-Angle', 'Humans', 'Intraocular Pressure', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Optic Disk', 'Prognosis', 'ROC Curve', 'Retrospective Studies', 'Visual Field Tests', 'Visual Fields'] | 29,118,453 | [['M01.060.116.100'], ['C23.550.291.656'], ['C11.525.381.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01.060.116.630'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['E01.789'], ['E05.318.370.800.750... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Performance analysis of different rice-based cropping systems in tropical region of Nepal. | Energy inputs, environmental impacts and economic outputs are the main concerns in today's agricultural production systems. The current study investigated the energy, environmental and financial performances of different rice-based cropping systems (CSs). The CSs studied were: Rice-Wheat-Fallow (R-W-F), Rice-Wheat-Maiz... | ['Agriculture', 'Nepal', 'Nitrous Oxide', 'Oryza', 'Seasons'] | 28,329,732 | [['J01.040'], ['Z01.252.245.674'], ['D01.362.635.625', 'D01.625.550.550', 'D01.650.550.587.650'], ['B01.650.940.800.575.912.250.822.616'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525']] | ['Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Novel synthesis of 5-amino-3-bromo-1-(tert-butyl)-1H-pyrazole-4-carbonitrile: a versatile intermediate for the preparation of 5-amino-3-aryl-1-(tert-butyl)-1H-pyrazole-4-carboxamides. | A simple, novel, and efficient route for the synthesis of 5-amino-3-aryl-1-(tert-butyl)-1H-pyrazole-4-carboxamides 1 has been devised. Preparation of pyrazole bromide 3 from potassium tricyanomethanide can be accomplished in only two steps in good yield and features a selective Sandmeyer reaction on the corresponding d... | ['Amides', 'Combinatorial Chemistry Techniques', 'Hydrocarbons, Brominated', 'Molecular Structure', 'Pyrazoles', 'Stereoisomerism'] | 22,809,236 | [['D02.065'], ['E05.197.312', 'J01.897.836.249.249'], ['D02.455.526.368'], ['G02.111.570', 'G02.466'], ['D03.383.129.539'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography. | BACKGROUND: Optical coherence tomography (OCT) is an optical imaging method that produces high-resolution cross-sectional images of the esophagus. The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established.OBJECTIVE: The purpose of this study was to identify and v... | ['Algorithms', 'Barrett Esophagus', 'Cardia', 'Epithelium', 'Gastroesophageal Reflux', 'Goblet Cells', 'Humans', 'Image Processing, Computer-Assisted', 'Intestinal Mucosa', 'Metaplasia', 'Observer Variation', 'Pancreas', 'Prospective Studies', 'Sensitivity and Specificity', 'Tomography, Optical Coherence'] | 17,137,858 | [['G17.035', 'L01.224.050'], ['C04.834.154', 'C06.405.117.102'], ['A03.556.875.875.163'], ['A10.272'], ['C06.405.117.119.500.484'], ['A03.556.124.369.320', 'A04.329.597.320', 'A04.531.520.320', 'A04.760.259', 'A10.615.550.444.321', 'A10.615.550.760.520.320', 'A10.615.550.760.600.320', 'A11.436.298'], ['B01.050.150.900.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The David and Goliath principle: cultural, ideological, and attitudinal underpinnings of the normative protection of low-status groups from criticism. | Two studies documented the "David and Goliath" rule--the tendency for people to perceive criticism of "David" groups (groups with low power and status) as less normatively permissible than criticism of "Goliath" groups (groups with high power and status). The authors confirmed the existence of the David and Goliath rul... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Asian Continental Ancestry Group', 'Attitude', 'Australia', 'Cross-Cultural Comparison', 'Cultural Diversity', 'Culture', 'Factor Analysis, Statistical', 'Female', 'Group Processes', 'Humans', 'Male', 'Middle Aged', 'Prejudice', 'Psychological Tests', 'Psychological... | 22,539,216 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.686.508.200'], ['F01.100'], ['Z01.639.100', 'Z01.678.100.373'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['I01.076.201.450.350', 'I01.880.853.100.450'], ['I01.076.201.450', 'I01.880.853.100'], ['E05.318.740.400', 'N05.715.360.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Design of smart EEG cap. | BACKGROUND AND OBJECTIVE: Brain machine interface (BMI) is a system which communicates the brain with the external machines. In general, an electroencephalograph (EEG) machine has to be used to monitor multi-channel brain responses to improve the BMI performance. However, the bulky size of the EEG machine and applying ... | ['Algorithms', 'Brain', 'Brain-Computer Interfaces', 'Electric Conductivity', 'Electrodes', 'Electroencephalography', 'Equipment Design', 'Head', 'Humans', 'Motion', 'Reproducibility of Results', 'Signal Processing, Computer-Assisted', 'Skin', 'Wireless Technology'] | 31,416,561 | [['G17.035', 'L01.224.050'], ['A08.186.211'], ['E07.305.076'], ['G01.358.500.249.277'], ['E07.305.250'], ['E01.370.376.300', 'E01.370.405.245'], ['E05.320'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.482'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['L01... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The effect of tubocurarine and suxamethonium on directly and indirectly elicited contractions of skeletal muscle in unanaesthetized man using single and train of four impulses. | 1 Contractions of adductor pollicis in unanaesthetized man were elicited by direct and indirect stimulation. Single twitch responses as well as those by a train of four impulses at 2 Hz for 2 s were elicited for indirect stimulation. 2 After a suitable control period, tubocurarine (0.05 mg/kg) or suxamethonium (0.08 mg... | ['Adult', 'Electric Stimulation', 'Humans', 'Muscle Contraction', 'Succinylcholine', 'Tubocurarine'] | 619,946 | [['M01.060.116'], ['E05.723.402'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494'], ['D02.092.877.883.333.780', 'D02.241.081.337.759.875', 'D02.675.276.232.780'], ['D02.092.877.922', 'D02.675.276.922', 'D03.132.098.916', 'D03.633.100.531.085.944', 'D03.633.100.531.820.875']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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