Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Hydrogen bonding patterns of calix[4]arenes with thiourea functionalities in solution and in the solid state. | [structure: see text] We have synthesized a number of calix[4]arene derivatives presenting thiourea functional groups at their upper rims by the condensation of a 1,3-di(p-amino)calix[4]arene with alkyl isothiocyanates. Mono- and dithiourea-substituted calix[4]arenes were prepared selectively in good yields, and homoco... | ['Calixarenes', 'Hydrogen Bonding', 'Models, Chemical', 'Molecular Conformation', 'Phenols', 'Solutions', 'Thiourea'] | 15,176,794 | [['D04.345.025'], ['G02.282'], ['E05.599.495'], ['G02.111.570.820'], ['D02.455.426.559.389.657'], ['D26.776'], ['D02.065.950.898', 'D02.886.904']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adaptive-weighted bilateral filtering and other pre-processing techniques for optical coherence tomography. | This paper presents novel pre-processing image enhancement algorithms for retinal optical coherence tomography (OCT). These images contain a large amount of speckle causing them to be grainy and of very low contrast. To make these images valuable for clinical interpretation, we propose a novel method to remove speckle,... | ['Algorithms', 'Fundus Oculi', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Optic Nerve', 'Tomography, Optical Coherence', 'Wavelet Analysis'] | 25,034,317 | [['G17.035', 'L01.224.050'], ['A09.371.729.313'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['A08.800.800.120.680'], ['E01.370.350.589.249.500', 'E01.370.350.825.805.500', 'E05.642.249.500'], ['E05.959'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Serratia entomophila inoculation causes a defect in exocytosis in Costelytra zealandica larvae. | Rapid elimination of midgut luminal proteinase activity and gut clearance are the two major symptoms of amber disease in Costelytra zealandica larvae because of the three-subunit protein toxin complex produced in Serratia entomophila and Serratia proteamaculans. Quantitative PCR analysis of mRNA from the major serine p... | ['Animals', 'Coleoptera', 'Cytoskeletal Proteins', 'Exocytosis', 'Gastrointestinal Tract', 'Larva', 'Pest Control, Biological', 'Serine Endopeptidases', 'Serratia', 'Time Factors'] | 18,651,919 | [['B01.050'], ['B01.050.500.131.617.720.500.500.375'], ['D12.776.220'], ['G04.468'], ['A03.556'], ['B05.500.500', 'G07.345.500.550.500.500'], ['N06.850.780.200.650.650'], ['D08.811.277.656.300.760', 'D08.811.277.656.959.350'], ['B03.440.450.425.814', 'B03.660.250.150.720'], ['G01.910.857']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Memory disruption by electrical stimulation of substantia nigra, pars compacta. | Electrical stimulation of the substantia nigra, pars compacta, of albino rats while they were learning a simple foot shock task of withdrawal and response suppression disrupted retention of that task 24 hours after original learning. Stimulation in the reticular zone of the substantia nigra was without effect on retent... | ['Animals', 'Avoidance Learning', 'Brain Stem', 'Electric Stimulation', 'Electrodes, Implanted', 'Male', 'Medulla Oblongata', 'Memory', 'Mesencephalon', 'Rats', 'Red Nucleus', 'Reticular Formation', 'Substantia Nigra', 'Time Factors'] | 4,714,294 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['A08.186.211.132'], ['E05.723.402'], ['E07.305.250.319', 'E07.695.202'], ['A08.186.211.132.810.591.500'], ['F02.463.425.540'], ['A08.186.211.132.659'], ['B01.050.150.900.649.313.992.635.505.700'], ['A08.186.211.132.659.413.875.642'], ['A08.186.211.132.772'], ['... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Species diversity and interspecific association in development sequence of Hippophae rhamnoides plantations in Loess hilly region]. | Based on field investigation, this paper analyzed the characteristics of species diversity and interspecific association at different development stages of Hippophcze rhamnoides plantations. The results showed that the species diversities of shrub layer, grass layer, and whole community of H. rharnnoides plantations we... | ['Biodiversity', 'Biomass', 'China', 'Desert Climate', 'Ecosystem', 'Hippophae'] | 17,396,492 | [['G16.500.275.157.049', 'N06.230.124.049'], ['G16.500.275.157.100', 'N06.230.124.100'], ['Z01.252.474.164'], ['G16.500.275.071.325', 'N06.230.300.100.250.325'], ['G16.500.275.157', 'N06.230.124'], ['B01.650.940.800.575.912.250.859.937.280.500']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Physico-chemical characterization of Ca-alginate microparticles produced with different methods. | In the present paper the physico-chemical characterization of Ca-alginate microparticles produced with different methods is presented. Ca-alginate microparticles were obtained either by emulsification method or by dripping an aqueous alginate solution into a solution of calcium salt. Inverse Size Exclusion Chromatograp... | ['Alginates', 'Biocompatible Materials', 'Chromatography, Gel', 'Cross-Linking Reagents', 'Emulsions', 'Epichlorohydrin', 'Glucuronic Acid', 'Hexuronic Acids', 'Hydrogen-Ion Concentration', 'Microscopy, Electron, Scanning', 'Surface Properties', 'Viscosity'] | 10,454,015 | [['D09.698.068'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E05.196.181.400.250'], ['D27.720.470.410.210'], ['D20.280.260', 'D26.255.165.260'], ['D02.355.291.411.400'], ['D02.241.081.844.915.162.249', 'D02.241.152.811.162.500', 'D02.241.511.902.915.162.500', 'D09.811.922.162.500'], ['D02.241.081.844.915.400'... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effect of HLA on immunological response to hepatitis B vaccine in healthy people: a meta-analysis. | BACKGROUND AND AIM: Evidence is accumulating that several markers in the human leukocyte antigen (HLA) region have been associated with decreased or increased antibody response to hepatitis B vaccine in different individuals. This meta-analysis is to assess the associations of HLA class II DRB1 and DQB1 alleles with im... | ['Antibody Formation', 'Cohort Studies', 'Female', 'Genetic Variation', 'HLA-DQ beta-Chains', 'HLA-DRB1 Chains', 'Hepatitis B Antibodies', 'Hepatitis B Vaccines', 'Hepatitis B virus', 'Humans', 'Male'] | 23,887,040 | [['G12.450.050.370.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G05.365'], ['D12.776.395.550.509.400.430.750', 'D12.776.543.550.440.400.430.750', 'D23.050.301.500.400.400.430.750', 'D23.050.301.500.450.400.430.750', 'D23.050.705.552.410.400.430.750', 'D23.050.705.552.450.400.4... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Lack of effects of hypoglycemia on glucose absorption in healthy men. | OBJECTIVE: To assess the effects of hypoglycemia on glucose absorption by examining the systemic appearance of 3-OMG (a glucose analogue that is transported by the same mechanism as glucose) after oral administration.RESEARCH DESIGN AND METHODS: Six healthy males 22-31 yr of age were studied during a hypoglycemic (50 m... | ['3-O-Methylglucose', 'Adult', 'Blood Glucose', 'Glucose', 'Glucose Clamp Technique', 'Humans', 'Hypoglycemia', 'Insulin', 'Intestinal Absorption', 'Kinetics', 'Male', 'Methylglucosides', 'Reference Values', 'Time Factors'] | 1,425,086 | [['D09.408.348.500.500', 'D09.408.514.622.500'], ['M01.060.116'], ['D09.947.875.359.448.500'], ['D09.947.875.359.448'], ['E01.370.225.124.100.350', 'E05.196.500', 'E05.200.124.100.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'],... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical and roentgenological profiles and etiological correlations of encysted pleural effusions. | One hundred and thirty-six cases of encysted pleural effusions were studied and investigated to reach an etiological diagnosis. The clinical profile of encysted pleural effusions differed little from that of free pleural effusions. Of the four sites of encystments seen (costoparietal, interlobar, subpulmonic, and media... | ['Adolescent', 'Adult', 'Cysts', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pleural Effusion', 'Radiography'] | 2,359,895 | [['M01.060.057'], ['M01.060.116'], ['C04.182', 'C23.300.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C08.528.652'], ['E01.370.350.700']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identifying Clinically Significant Irritability in Early Childhood. | OBJECTIVE: Advances in developmentally sensitive measurement have enabled differentiation of normative versus clinically salient irritability in early childhood. However, clinical application of these measures is still nascent. The authors developed an optimized model of clinically salient irritable behaviors at presch... | ['Attention Deficit and Disruptive Behavior Disorders', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Irritable Mood', 'Longitudinal Studies', 'Male', 'Problem Behavior', 'Psychiatric Status Rating Scales'] | 29,496,128 | [['F03.625.094'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.470.047.110'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F01.145.126.972', 'F01.145.179.750'], ['F04.711.513.653']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Endoscopic sclerotherapy in acute variceal hemorrhage. | Acute variceal hemorrhage in patients with alcoholic cirrhosis and poor liver function is associated with a high mortality. A nonoperative treatment, endoscopic sclerotherapy, was employed in 22 patients with cirrhosis and poor liver function who had 24 episodes of acute variceal hemorrhage over a 20 month period. Port... | ['Adult', 'Esophageal and Gastric Varices', 'Esophagoscopy', 'Female', 'Gastrointestinal Hemorrhage', 'Humans', 'Hypertension, Portal', 'Liver Cirrhosis, Alcoholic', 'Male', 'Middle Aged', 'Sclerosing Solutions'] | 6,970,002 | [['M01.060.116'], ['C06.405.117.240', 'C06.552.494.414'], ['E01.370.372.250.250.275', 'E01.370.388.250.250.250.260', 'E04.210.240.250.260', 'E04.502.250.250.250.260'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.494'], ['C06.552.630.380', 'C06.552.645.590', 'C23.550.35... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genomic and transcriptomic plasticity in treatment-naive ovarian cancer. | Intra-tumor heterogeneity is a hallmark of many cancers and may lead to therapy resistance or interfere with personalized treatment strategies. Here, we combined topographic mapping of somatic breakpoints and transcriptional profiling to probe intra-tumor heterogeneity of treatment-na?ve stage IIIC/IV epithelial ovaria... | ['Aged', 'Chromosome Aberrations', 'Cyclin-Dependent Kinase Inhibitor p16', 'Fanconi Anemia Complementation Group D2 Protein', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Genome, Human', 'Humans', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplasm Staging', 'Neurofibromatosis 1', 'Ome... | 24,221,193 | [['M01.060.116.100'], ['C23.550.210', 'G05.365.590.175'], ['D12.644.360.225.200', 'D12.776.167.187.200', 'D12.776.476.225.200', 'D12.776.624.776.355.200'], ['D12.776.313.812', 'D12.776.660.285', 'D12.776.744.484'], ['E05.393.332'], ['G05.308.370'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], [... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus. | In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not clear. We hypothesize that the mechanism involves corticosteroid-induced alterations in the uptake of 5-HT from extracel... | ['Analysis of Variance', 'Animals', 'Dose-Response Relationship, Drug', 'Extracellular Fluid', 'Grooming', 'Hypothalamus, Middle', 'Male', 'Microdialysis', 'Organic Cation Transport Proteins', 'Quinolines', 'Rats', 'Rats, Wistar', 'Serotonin', 'Statistics, Nonparametric'] | 16,266,691 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.284.295.260', 'A12.207.270'], ['F01.145.113.111.453'], ['A08.186.211.180.497.352', 'A08.186.211.200.317.357.352'], ['E05.196.353.500'], ['D12.776.157.530.450.250.812', 'D12.776.157.530.937.612'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Photochemical Anti-Fouling Approach for Electrochemical Pollutant Degradation on Facet-Tailored TiO2 | Electrochemical degradation of refractory pollutants at low bias before oxygen evolution exhibits high current efficiency and low energy consumption, but its severe electrode fouling largely limits practical applications. In this work, a new antifouling strategy was developed and validated for electrochemical pollutant... | ['Electrodes', 'Titanium', 'Waste Water', 'Water Pollutants, Chemical', 'Water Purification'] | 28,891,634 | [['E07.305.250'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.547.800'], ['D20.944.932', 'N06.850.460.710.865'], ['D27.888.284.903.655'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Microbial colonization is required for normal neurobehavioral development in zebrafish. | Changes in resident microbiota may have wide-ranging effects on human health. We investigated whether early life microbial disruption alters neurodevelopment and behavior in larval zebrafish. Conventionally colonized, axenic, and axenic larvae colonized at 1 day post fertilization (dpf) were evaluated using a standard ... | ['Aeromonas veronii', 'Animals', 'Anti-Bacterial Agents', 'Behavior, Animal', 'Embryo, Nonmammalian', 'Gastrointestinal Microbiome', 'Larva', 'Locomotion', 'Nervous System', 'Vibrio cholerae', 'Zebrafish'] | 28,894,128 | [['B03.440.450.019.025.845'], ['B01.050'], ['D27.505.954.122.085'], ['F01.145.113'], ['A13.350', 'A16.331'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G07.568.500', 'G11.427.410.568'], ['A08'], ['B03.440.450.900.859.225', 'B03.660.25... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Cotton Rat as a Model for Staphylococcus aureus nasal colonization in humans: cotton rat S. aureus nasal colonization model. | Staphylococcus aureus nasal colonization is a well-known risk factor for development of S.aureus infections in humans, but despite this established association, we are only beginning to understand the factors, both host and pathogen, that play a role in the colonization of the nares by S. aureus. The cotton rat is a mo... | ['Animals', 'Disease Models, Animal', 'Humans', 'Nose', 'Rats', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Time Factors'] | 18,287,761 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.456.505.733', 'A04.531', 'A09.531'], ['B01.050.150.900.649.313.992.635.505.700'], ['C01.150.252.410.868'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100', 'B03.510.40... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of cervical lymph node metastasis in esophageal carcinoma using ultrasonography. | OBJECTIVE: To evaluate the efficacy of ultrasonography for the diagnosis of cervical lymph node metastasis in esophageal carcinoma.SUMMARY BACKGROUND DATA: Ultrasound (US) examination is useful for diagnosing lymph node metastasis. However, few reports have examined its role in the decision to perform cervical lymph no... | ['Esophageal Neoplasms', 'Humans', 'Lymphatic Metastasis', 'Neck', 'Reproducibility of Results', 'Ultrasonography'] | 9,923,801 | [['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['A01.598'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E01.370.350.850']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evaluation of Sepsis Flow Chip for identification of Gram-negative bacilli and detection of antimicrobial resistance genes directly from positive blood cultures. | Blood stream infections are serious conditions associated with high morbi-mortality. In this study, the new Sepsis Flow Chip (SFC) assay for identification of Gram-negative bacteria and their antimicrobial resistance genes was evaluated in positive blood cultures (BCs). SFC is a microarray with a broad panel comprising... | ['Blood Culture', 'Gram-Negative Bacterial Infections', 'Humans', 'Microarray Analysis', 'Microbial Sensitivity Tests', 'Molecular Diagnostic Techniques', 'Oligonucleotide Array Sequence Analysis', 'Prospective Studies', 'Sepsis', 'Time Factors'] | 29,551,362 | [['E01.370.225.875.185', 'E05.200.875.185'], ['C01.150.252.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.588.570'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E01.370.225.880', 'E05.200.880', 'E05.393.520'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
1-C-glucuronidation of N-nitrosodiethylamine and N-nitrosomethyl-n-pentylamine in vivo and in primary hepatocytes from rats pretreated with inducers. | The organ specificity of the carcinogenic action of nitrosamines is partly explained by organ specific activation. The specificity might also be determined by conjugation of reactive intermediates in e.g. the liver. 14C-Labeled N-nitrosodiethylamine (NDEA) a liver carcinogen and N-nitrosomethyl-n-pentylamine (NMPentA) ... | ['Animals', 'Aroclors', 'Chromatography, High Pressure Liquid', 'Diethylnitrosamine', 'Enzyme Induction', 'Glucuronates', 'Glucuronosyltransferase', 'Male', 'Methylcholanthrene', 'Microsomes, Liver', 'Nitrosamines', 'Organ Specificity', 'Phenobarbital', 'Rats', 'Rats, Inbred Strains', 'Substrate Specificity', 'Urinary ... | 1,587,001 | [['B01.050'], ['D02.309.750.500', 'D02.455.526.439.773.292', 'D02.455.526.439.785.292'], ['E05.196.181.400.300'], ['D02.654.442.200'], ['G05.308.320.200'], ['D02.241.081.844.915.162', 'D02.241.152.811.162', 'D02.241.511.902.915.162', 'D09.811.922.162'], ['D08.811.913.400.450.480'], ['D02.455.426.559.847.149.500', 'D04.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Plasma miR-126 expression correlates with risk and severity of psoriasis and its high level at baseline predicts worse response to Tripterygium wilfordii Hook F in combination with acitretin. | BACKGROUND: Treatment of psoriasis is always difficult, which requires intensive scientific research.OBJECTIVE: Tripterygium wilfordii Hook F (TwHF) with acitretin(TwHF + acitretin) is normally used in treating psoriasis. This study aimed to investigate the correlation of plasma miR-126 expression with risk and severit... | ['Acitretin', 'Adult', 'Female', 'Gene Expression Regulation', 'Humans', 'Keratolytic Agents', 'Male', 'MicroRNAs', 'Middle Aged', 'Plant Extracts', 'Psoriasis', 'Risk Factors', 'Treatment Outcome', 'Tripterygium'] | 31,100,542 | [['D02.455.326.271.665.202.495.050', 'D02.455.849.131.495.050', 'D23.767.261.700.050'], ['M01.060.116'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.954.444.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['M01.060.116.630'], ['D20.215.784.500', 'D26.667'], ['C1... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Blood pressure related separately to parenchymal fibrosis and vasculopathy of the kidney. | The term nephrosclerosis is customarily used to designate a pathological entity that tends to characterize subjects with high blood pressure; it refers to a condition of diffuse fibrous replacement of renal substance secondary to ischemia from hypertension-related vascular injury. The features of parenchymal fibrosis c... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Blood Pressure', 'Fibrosis', 'Humans', 'Hypertension, Renovascular', 'Kidney', 'Middle Aged', 'Nephrosclerosis', 'Vascular Diseases'] | 1,496,964 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.550.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.331.490', 'C13.351.968.419.331.490', 'C14.907.489.631.485'], ['A0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Using natural clinoptilolite zeolite as an amendment in vermicomposting of food waste. | The effect of adding different proportions of natural clinoptilolite zeolite (5 and 10%) to food waste vermicomposting was investigated by assessing the physicochemical characteristics, worms' growth, and maturation time of finished vermicompost in comparison with the vermicompost prepared with no amendment (control). ... | ['Animals', 'Carbon', 'Composting', 'Dose-Response Relationship, Drug', 'Garbage', 'Iran', 'Nitrogen', 'Oligochaeta', 'Population Dynamics', 'Zeolites'] | 29,860,684 | [['B01.050'], ['D01.268.150'], ['N06.850.780.200.800.800.700.500', 'N06.850.860.510.900.600.200'], ['G07.690.773.875', 'G07.690.936.500'], ['N06.850.860.510.900.600.400'], ['Z01.252.245.500.350'], ['D01.268.604', 'D01.362.625'], ['B01.050.500.091.657'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['D01.056.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Biological assessment of sintered titanium alloy for dental crown and bridge by means of slip casting]. | OBJECTIVE: To evaluate the biological safety of sintered titanium alloy for dental crown and bridge, and provide a sound scientific basis for dental clinical practice.METHODS: A series of tests, including acute toxicity test, cytotoxity test (agar overlay), sensitization test, oral mucous membrane irritation test, haem... | ['Animals', 'Cricetinae', 'Crowns', 'Cytotoxicity Tests, Immunologic', 'Dental Alloys', 'Dental Casting Technique', 'Dental Porcelain', 'Denture, Partial', 'Female', 'Guinea Pigs', 'Male', 'Mice', 'Micronucleus Tests', 'Titanium'] | 12,600,101 | [['B01.050'], ['B01.050.150.900.649.313.992.635.075.250'], ['E06.780.346.250', 'E07.695.190.088'], ['E01.370.225.812.160', 'E05.200.812.160', 'E05.478.594.160', 'E05.940.245'], ['D25.339.208', 'J01.637.051.339.208'], ['E06.780.250', 'E06.912.115'], ['D25.339.376', 'J01.637.051.339.376', 'J01.637.153.377'], ['E06.780.34... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
An investigation using lectins of glycocomponents of mouse spermatozoa during capacitation and sperm-zona binding. | Ten different lectins conjugated to fluorescein isothiocyanate (FITC) were used to study the distribution of surface carbohydrates on mouse spermatozoa, and to monitor the possible changes of their distribution during capacitation in vitro and sperm-egg interaction. Most of the lectins gave a restricted pattern of bind... | ['Animals', 'Binding Sites', 'Carbohydrates', 'Cell Wall', 'Female', 'Lectins', 'Male', 'Mice', 'Mice, Inbred Strains', 'Sperm Capacitation', 'Sperm-Ovum Interactions', 'Spermatozoa'] | 3,598,974 | [['B01.050'], ['G02.111.570.120'], ['D09'], ['A11.284.183'], ['D12.776.503'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['G08.686.784.277.760'], ['G08.686.784.277.800'], ['A05.360.490.890', 'A11.497.760']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Solid pseudopapillary tumor of the pancreas: a rare and probably misdiagnosed neoplasm. | Solid Pseudopapillary Tumor of the pancreas is a rare nonfunctioning tumor. It is considered a low-grade malignancy that is apparently curable with surgical complete excision in most instances. We present a case of solid pseudopapillary pancreatic tumor that represented a challenge to the radiologists. This case highli... | ['Adult', 'Carcinoma, Papillary', 'Diagnostic Errors', 'Female', 'Humans', 'Pancreatic Neoplasms'] | 22,470,804 | [['M01.060.116'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['E01.354', 'N02.421.450.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life. | The gut microbiota is central to human health, but its establishment in early life has not been quantitatively and functionally examined. Applying metagenomic analysis on fecal samples from a large cohort of Swedish infants and their mothers, we characterized the gut microbiome during the first year of life and assesse... | ['Adult', 'Breast Feeding', 'Delivery, Obstetric', 'Feces', 'Gastrointestinal Microbiome', 'Gastrointestinal Tract', 'Humans', 'Infant', 'Infant, Newborn', 'Metagenomics', 'Microbiota', 'Molecular Sequence Data', 'Sequence Analysis, DNA', 'Sweden'] | 25,974,306 | [['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['E04.520.252'], ['A12.459'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['A03.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'],... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Dental service mix among older adults aged 65 and over, United States, 1999 and 2009. | OBJECTIVES: The oral health of older Americans will assume increasing importance because of their increasing numbers and the evolving connections between oral health and general health. To establish a baseline and provide data for oral health workforce models, this report describes the types of dental procedures receiv... | ['Aged', 'Dental Health Services', 'Humans', 'Insurance, Dental', 'Poverty', 'United States'] | 24,428,804 | [['M01.060.116.100'], ['N02.421.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.450'], ['I01.880.735.634', 'I01.880.853.996.535', 'N01.824.600'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Clinical presentation and initial management of black men and white men with prostate cancer in the United Kingdom: the PROCESS cohort study. | BACKGROUND: In the United States, Black men have a higher risk of prostate cancer and worse survival than do White men, but it is unclear whether this is because of differences in diagnosis and management. We re-examined these differences in the United Kingdom, where health care is free and unlikely to vary by socioeco... | ['African Continental Ancestry Group', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'European Continental Ancestry Group', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Retrospective Studies', 'United Kingdom'] | 19,935,788 | [['M01.686.508.100'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['D08.811.277.656.300.760... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Protamine increases the affinity of 3'-phosphoadenosine 5'-phosphosulfate toward a sulfotransferase from chicken embryo epiphyseal cartilage. | A 3' -phosphoadenosine 5' -phosphosulfate (PAPS):chondroitin sulfate sulfotransferase from chicken embryo epiphyseal cartilage, which was partially purified, exhibited a molecular mass of 150 kDa. The enzymatic sulfation of totally desulfated chondroitin was activated up to 12-fold by protamine while the sulfation of p... | ['Adenine Nucleotides', 'Animals', 'Chick Embryo', 'Chondroitin', 'Chondroitin Sulfates', 'Enzyme Activation', 'Kinetics', 'Phosphoadenosine Phosphosulfate', 'Protamines', 'Sulfotransferases', 'Sulfurtransferases'] | 3,092,873 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['D09.698.373.200'], ['D09.698.373.200.300'], ['G02.111.263', 'G03.328'], ['G01.374.661', 'G02.111.490'], ['D03.633.100.759.646.138.850', 'D13.695.667.138.850', 'D13.695.827.068.850'], ['D12.776.660.750', 'D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prolonged urokinase infusion for chronic total native coronary occlusions: clinical, angiographic, and treatment observations. | Prolonged intravascular infusion of urokinase has proven beneficial in reestablishing patency of chronically occluded peripheral arteries and saphenous vein grafts. This study was performed to assess the efficacy and safety of prolonged urokinase infusion as a prelude to angioplasty in chronically occluded native coron... | ['Adult', 'Aged', 'Aneurysm, Dissecting', 'Angina Pectoris', 'Angioplasty, Balloon, Coronary', 'Chronic Disease', 'Combined Modality Therapy', 'Coronary Aneurysm', 'Coronary Angiography', 'Coronary Circulation', 'Coronary Disease', 'Coronary Thrombosis', 'Drug Administration Schedule', 'Electrocardiography', 'Female', ... | 7,788,687 | [['M01.060.116'], ['M01.060.116.100'], ['C14.907.055.050'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.06... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Size of the direct-to-consumer genomic testing market. | There has been enormous interest in the recent development of consumer genomics services, but very little is known about their impact. Using publicly available information, we estimate that the market for genetic susceptibility tests for complex diseases is much smaller than previously suggested, and hence consider tha... | ['Consumer Advocacy', 'Genetic Predisposition to Disease', 'Genetic Privacy', 'Genetic Testing', 'Genome, Human', 'Genomics', 'Humans', 'Marketing of Health Services'] | 20,697,288 | [['I01.880.604.473.368', 'N03.706.437.368'], ['C23.550.291.687.500', 'G05.380.355'], ['I01.880.604.473.352.500.320', 'I01.880.604.473.650.500.320', 'I01.880.604.583.080.320', 'N03.706.437.352.500.320', 'N03.706.437.650.124.320', 'N03.706.535.230.320'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430'... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Characterization of cardiac hypertrophy and heart failure due to volume overload in the rat. | Alterations in general characteristics and morphology of the heart, as well as changes in hemodynamics, myosin heavy chain isoforms, and beta-adrenoceptor responsiveness, were determined in Sprague-Dawley rats at 1, 2, 4, 8, and 16 wk after aortocaval fistula (shunt) was induced by the needle technique. Three stages of... | ['Animals', 'Arteries', 'Cardiac Output, Low', 'Cardiomegaly', 'Coronary Circulation', 'Heart', 'Hemodynamics', 'Hyperemia', 'Isoenzymes', 'Isoproterenol', 'Male', 'Myocardial Contraction', 'Myocardium', 'Myosins', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Adrenergic, beta'] | 12,531,914 | [['B01.050'], ['A07.015.114'], ['C14.280.148', 'C23.888.192'], ['C14.280.195', 'C23.300.775.250'], ['G09.330.100.324'], ['A07.541'], ['G09.330.380'], ['C14.907.474'], ['D08.811.348', 'D12.776.800.300'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['G09.330.5... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
P16INK4A overexpression predicts lymph node metastasis in cervical carcinomas. | BACKGROUND: The p16(INK4A) protein (p16) is a cyclin-dependent kinase inhibitor that arrests the cell cycle in the G1 phase.AIM: To explore the potential of p16 as a predictive marker for lymph node (LN) metastasis and prognosis in cervical carcinomas.METHODS: 145 patients diagnosed with FIGO stage I to IV cervical car... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Carcinoma', 'Carcinoma, Adenosquamous', 'Carcinoma, Squamous Cell', 'Cyclin-Dependent Kinase Inhibitor p16', 'Female', 'Humans', 'Lymph Node Excision', 'Lymph Nodes', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Staging', 'Pelvis', 'Prog... | 22,011,452 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.557.470.200'], ['C04.557.435.250', 'C04.557.470.200.150'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D12.644.360.225.200', 'D12.776.167.187.200', 'D12.776.476.225.200', 'D12.776.624.776.355.200'], ['B... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Outcomes of fertility-sparing surgery among young women with FIGO stage I clear cell carcinoma of the ovary. | OBJECTIVES: To evaluate the outcome of fertility-sparing surgery among young women with early-stage clear cell carcinoma of the ovary.METHODS: In a retrospective study, data were reviewed for patients aged 45years or younger who had FIGO stage I clear cell carcinoma of the ovary and had attended one institution in Sout... | ['Adenocarcinoma, Clear Cell', 'Adult', 'Disease-Free Survival', 'Female', 'Fertility Preservation', 'Humans', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Organ Sparing Treatments', 'Ovarian Neoplasms', 'Ovary', 'Republic of Korea', 'Retrospective Studies'] | 27,039,052 | [['C04.557.470.200.025.045'], ['M01.060.116'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E02.875.800.625', 'E04.936.537.562', 'E05.820.800.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effect of mouth leak on effectiveness of nasal bilevel ventilatory assistance and sleep architecture. | Mouth leak is common during nasal ventilatory assistance, but its effects on ventilatory support and on sleep architecture are unknown. The acute effect of sealing the mouth on sleep architecture and transcutaneous carbon dioxide tension (Ptc,CO2) was tested in 9 patients (7 hypercapnic) on longterm nasal bilevel venti... | ['Aged', 'Carbon Dioxide', 'Equipment Failure', 'Equipment Safety', 'Female', 'Humans', 'Intermittent Positive-Pressure Ventilation', 'Laryngeal Masks', 'Lung Diseases, Obstructive', 'Male', 'Middle Aged', 'Models, Biological', 'Mouth Breathing', 'Polysomnography', 'Respiratory Function Tests', 'Risk Assessment', 'Slee... | 10,624,751 | [['M01.060.116.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['E05.325'], ['E05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.625.790.550', 'E02.880.820.790.550'], ['E02.041.500.475', 'E02.585.578.475', 'E05.497.578.475', 'E07.700.500.450', 'J01.637.708.560.782.450'], ['C08.381.495'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
A qualitative study of motivations for meditation in anthroposophic practitioners. | Research on meditation is advancing, but few studies about the motivations of meditators exist. Additionally, many forms and traditions of meditation have yet to be investigated. This study addresses both of these issues by presenting an overview of different forms of motivations found in contemporary Anthroposophic me... | ['Anthroposophy', 'Attitude of Health Personnel', 'Female', 'Health Personnel', 'Humans', 'Male', 'Meditation', 'Middle Aged', 'Motivation', 'Qualitative Research'] | 30,212,522 | [['E02.190.088', 'K01.844.058'], ['F01.100.050', 'N05.300.100'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.374', 'E02.190.901.455', 'F04.754.137.750.500'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['H01.770.644.241.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice. | Advanced age is a risk factor of severe acute respiratory syndrome (SARS) in humans. To understand its pathogenesis, we developed an animal model using BALB/c mice and the mouse-passaged Frankfurt 1 isolate of SARS coronavirus (SARS-CoV). We examined the immune responses to SARS-CoV in both young and adult mice. SARS-C... | ['Aging', 'Animals', 'Cytokines', 'Disease Models, Animal', 'Female', 'Humans', 'Mice', 'Mice, Inbred BALB C', 'Pulmonary Alveoli', 'Pulmonary Edema', 'SARS Virus', 'Severe Acute Respiratory Syndrome', 'Virus Replication'] | 18,467,696 | [['G07.345.124'], ['B01.050'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['A04.411... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serotonergic or Anticholinergic Toxidrome: Case Report of a 9-Year-Old Girl. | OBJECTIVE: The aim of this study was to report an acute onset of symptoms erroneously attributed to serotonin syndrome in a child who had been given both anticholinergic and serotonergic agents.CASE SUMMARY: A 9-year-old girl with chronic anxiety and gastrointestinal problems was prescribed oral sertraline 6.25 mg dail... | ['Anticholinergic Syndrome', 'Child', 'Cholinergic Antagonists', 'Diagnosis, Differential', 'Female', 'Humans', 'Serotonin Agents', 'Serotonin Syndrome', 'Serotonin Uptake Inhibitors', 'Sertraline'] | 26,425,930 | [['C25.100.311'], ['M01.060.406'], ['D27.505.519.625.120.200', 'D27.505.696.577.120.200'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.625.850', 'D27.505.696.577.850'], ['C25.100.875'], ['D27.505.519.562.437.850', 'D27.505.519.625.600.850', 'D27.505.519.625.850.900', 'D27.505.696.577.600... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of the rolling circle amplification and ligase-dependent reaction methods for the identification of opportunistic Exophiala species. | We developed two ligase-dependent probe amplification assays based on rolling circle amplification (RCA) and the ligase-dependent reaction (LDR) to differentiate species of Exophiala targeting the rDNA internal transcribed spacer region. We focused on Exophiala dermatitidis and E. phaeomuriformis, two opportunistic inh... | ['DNA, Fungal', 'DNA, Ribosomal Spacer', 'Exophiala', 'Humans', 'Mycological Typing Techniques', 'Nucleic Acid Amplification Techniques', 'Reproducibility of Results'] | 29,087,521 | [['D13.444.308.300'], ['D13.444.308.324.230', 'D13.444.308.475.230'], ['B01.300.107.366', 'B01.300.381.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.610', 'E05.200.875.610'], ['E05.393.620'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Seronegative spondylarthropathy without spine involvement in Beh?et's syndrome. | The case of a 49-year-old man affected by Beh?et's syndrome (BS) without any clinical or radiological evidence of ankylosing spondylitis, exhibiting a peripheral enthesitis typical of seronegative spondyloarthropathy (SpA) is reported. The diagnosis of SpA is supported by computed tomographic evidence of sacroiliitis. ... | ['Achilles Tendon', 'Antigen-Antibody Reactions', 'Arthritis', 'Behcet Syndrome', 'Humans', 'Joint Diseases', 'Male', 'Middle Aged', 'Patella', 'Sacroiliac Joint', 'Spinal Diseases', 'Tendinopathy', 'Tomography, X-Ray Computed'] | 8,258,243 | [['A02.880.176'], ['G12.122'], ['C05.550.114'], ['C07.465.075', 'C11.941.879.780.880.200', 'C14.907.940.100', 'C16.320.382.250', 'C17.800.827.368.250', 'C17.800.862.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550'], ['M01.060.116.630'], ['A02.835.232.043.650.624', 'A02.835.232.730.500'], ['A02.835.583... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol. | Octadecadienoic acids (linoleic acid and linolelaidic acid) and the diacylglycerol, 1-oleoyl-2-acetyl-rac-glycerol (OAG) concentration-dependently induced activation of gel-filtered human platelets, i.e. aggregation and phosphorylation of 20 kDa and 47 kDa peptides. In contrast, octadecenoic acids (oleic and elaidic ac... | ['Blood Platelets', 'Diglycerides', 'Enzyme Activation', 'Glycerides', 'Humans', 'Phosphorylation', 'Platelet Aggregation', 'Protein Kinase C', 'Proteins', 'Stearic Acids'] | 3,426,598 | [['A11.118.188', 'A15.145.229.188'], ['D10.351.303'], ['G02.111.263', 'G03.328'], ['D10.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['G09.188.370.687', 'G09.188.390.600.640'], ['D08.811.913.696.620.682.700.725'], ['D12.776'], ['D10.251.882']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alteration of insulin signaling to control insect pest by using transformed bacteria expressing dsRNA. | BACKGROUND: Insulin/insulin-like growth factor signaling (IIS) is known to mediate larval growth and adult reproduction in the legume pod borer, Maruca vitrata (Lepidoptera: Crambidae). Four IIS components (InR, FOXO, Akt, and TOR) play crucial roles in the IIS pathway.RESULTS: RNA interference (RNAi) against any of th... | ['Animals', 'Bacillus thuringiensis', 'Insect Control', 'Insulin', 'Larva', 'Moths', 'RNA Interference', 'RNA, Double-Stranded', 'Signal Transduction'] | 31,503,391 | [['B01.050'], ['B03.300.390.400.158.218.800', 'B03.353.500.100.218.800', 'B03.510.100.100.218.800', 'B03.510.415.400.158.218.800', 'B03.510.460.410.158.218.800'], ['N06.850.780.200.650.425'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.131.61... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Responses of cells in the auditory cortex of awake squirrel monkeys to normal and reversed species-specific vocalizations. | Natural vocalizations and their artificial counterparts were found to be equally effective in evoking responses in auditory cortex units of awake squirrel monkeys. Neural responsiveness was presumably based primarily on the sensitivity of the units to acoustic transients embedded in the stimuli. For the left hemisphere... | ['Animals', 'Auditory Cortex', 'Evoked Potentials, Auditory', 'Functional Laterality', 'Neurons', 'Saimiri', 'Vocalization, Animal'] | 6,826,464 | [['B01.050'], ['A08.186.211.200.885.287.500.814.249', 'A08.186.211.200.885.287.500.863.297'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['F02.830.297.425', 'G11.561.225.425'], ['A08.675', 'A11.671'], ['B01.050.150.900.649.313.988.400.600.150.710.710'], ['F01.145.113.055.800']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. | BACKGROUND: In subjects with hypersensitivity reactions with cross-intolerance to nonsteroidal anti-inflammatory drugs (NSAIDs), tolerance to selective COX-2 inhibitors has not been evaluated in large series of well-phenotyped cases.METHODS: We evaluated 252 patients with urticaria and/or angioedema caused by hypersens... | ['Acetaminophen', 'Adolescent', 'Adult', 'Angioedema', 'Anti-Inflammatory Agents, Non-Steroidal', 'Aspirin', 'Cyclooxygenase 2 Inhibitors', 'Drug Hypersensitivity', 'Etoricoxib', 'Humans', 'Hypersensitivity, Immediate', 'Ibuprofen', 'Pyridines', 'Single-Blind Method', 'Sulfones', 'Urticaria', 'Young Adult'] | 21,834,936 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['M01.060.057'], ['M01.060.116'], ['C14.907.079', 'C17.800.862.945.066', 'C20.543.480.904.066'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D02.455.426.559.389.657.410.595.176'], ['D27.505.519.389.310.500', 'D27.505.696.663.8... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Utilization of complementary and integrative health services and opioid therapy by patients receiving Veterans Health Administration pain care. | OBJECTIVES: The aims of the current study were to characterize veterans who used a complementary and integrative health (CIH) service in the Veterans Health Administration (VHA) and to assess the extent to which using a CIH-related service was associated with receiving an opioid analgesic prescription following the ini... | ['Adolescent', 'Adult', 'Aged', 'Analgesics, Opioid', 'Complementary Therapies', 'Female', 'Humans', 'Integrative Medicine', 'Male', 'Middle Aged', 'Pain Management', 'Retrospective Studies', 'United States', 'United States Department of Veterans Affairs', 'Veterans', 'Veterans Health', 'Young Adult'] | 30,012,396 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['E02.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.400'], ['M01.060.116.630'], ['E02.745', 'N04.590.607.500'], ['E05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Necrotizing enterocolitis induced by local circulatory interruption in the ileum of neonatal piglets. | Occlusion of groups of vessels in the mesenteric vascular arcades of distal ileum for 48 h induced necrotizing enterocolitis lesions in low birth weight, spontaneously delivered, neonatal piglets. Lesion severity increased with numbers of adjacent groups of vessels occluded and with proximity to the ileocecal junction.... | ['Animals', 'Animals, Newborn', 'Birth Weight', 'Enterocolitis, Pseudomembranous', 'Ileum', 'Mesenteric Arteries', 'Mesenteric Veins', 'Regional Blood Flow', 'Reperfusion Injury', 'Swine'] | 1,561,146 | [['B01.050'], ['B01.050.050.282'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['C01.150.252.410.222.310', 'C06.405.205.596.800', 'C06.405.469.363.800'], ['A03.556.124.684.249', 'A03.556.249.124'], ['A07.015.114.565'], ['A07.01... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector Anopheles gambiae. | BACKGROUND: During copulation, the major Afro-tropical malaria vector Anopheles gambiae s.s. transfers male accessory gland (MAG) proteins to females as a solid mass (i.e. the "mating plug"). These proteins are postulated to function as important modulators of female post-mating responses. To understand the role of sel... | ['Animals', 'Anopheles', 'Bayes Theorem', 'Blotting, Western', 'Chromosome Mapping', 'Computational Biology', 'Drosophila Proteins', 'Evolution, Molecular', 'Female', 'Haplotypes', 'In Situ Hybridization, Fluorescence', 'Insect Hormones', 'Intercellular Signaling Peptides and Proteins', 'Male', 'Microscopy, Fluorescenc... | 21,978,124 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.875.120'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.393.183'], ['H01.158.273.180', 'L01.313.124'], ['D12.776.093.50... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Female roles and conflicts in health care professions]. | UNLABELLED: The burdens of the caring and curing professions are increased in the female workforce by childbearing and the duties of childrearing, and serving a family as well.AIM: the objective of our research was to study and compare future and present family and career plans of students and active professionals (nur... | ['Burnout, Professional', 'Career Choice', 'Caregivers', 'Conflict, Psychological', 'Cross-Sectional Studies', 'Family', 'Female', 'Health Behavior', 'Health Status', 'Humans', 'Hungary', 'Job Satisfaction', 'Mental Health', "Nurse's Role", 'Nurses', "Physician's Role", 'Physicians', 'Students, Medical', 'Students, Nur... | 19,470,425 | [['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['F02.463.785.373.346.400'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F01.658.209'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.829.263', 'I01.880.853.150'], ['F01.145.488'], ['I01.240.425', 'N01.224.42... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Collagenase and fibronectin in bronchoalveolar lavage fluid in patients with sarcoidosis. | Bronchoalveolar lavage fluid from 43 patients with biopsy proved sarcoidosis and 10 control subjects were assayed for fibronectin and collagenase activity. Fibronectin was significantly increased in the group with sarcoidosis and was found to be positively correlated with angiotensin converting enzyme activity, protein... | ['Adult', 'Aged', 'Bronchoalveolar Lavage Fluid', 'Female', 'Fibronectins', 'Follow-Up Studies', 'Humans', 'Lung', 'Lung Diseases', 'Male', 'Microbial Collagenase', 'Middle Aged', 'Sarcoidosis'] | 2,848,327 | [['M01.060.116'], ['M01.060.116.100'], ['E05.927.100.500'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.381'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcription factor genes of Schizophyllum commune involved in regulation of mushroom formation. | Mushrooms represent the most conspicuous structures of fungi. Their development is being studied in the model basidiomycete Schizophyllum commune. The genome of S. commune contains 472 genes encoding predicted transcription factors. Of these, fst3 and fst4 were shown to inhibit and induce mushroom development respectiv... | ['Agaricales', 'Gene Expression Profiling', 'Gene Expression Regulation, Fungal', 'Gene Knockout Techniques', 'Genes, Fungal', 'Models, Biological', 'Schizophyllum', 'Transcription Factors'] | 21,815,946 | [['B01.300.179.100'], ['E05.393.332'], ['G05.308.330'], ['E05.393.335.750'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['E05.599.395'], ['B01.300.179.100.750'], ['D12.776.930']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary. | A few years before reproductive senescence, primordial follicles are depleted from the ovary at a dramatically accelerated rate. It has been proposed that this depletion is due to transient increases in gonadotropin levels. To test this hypothesis, we used mice that produce chronically elevated levels of serum LH via e... | ['Animals', 'Female', 'Follicular Atresia', 'Luteinizing Hormone', 'Mice', 'Mice, Transgenic', 'Ovarian Follicle', 'Ovary'] | 9,369,192 | [['B01.050'], ['G08.686.290'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['A05.360.319.114.630', 'A05.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nasopharyngeal carcinoma in Israel: epidemiology and Epstein-Barr virus-related serology. | Epidemiological, histological and serological characteristics of nasopharyngeal carcinoma (NPC) were investigated. Included were 25 patients aged 10-70 with male to female ratio 2:1. Among 23 Jewish patients, 18 were of Asian-African (AA) and five of European (Eur) descent; two were Arabs (Ar). The dominant histologica... | ['Adolescent', 'Adult', 'Aged', 'Antibodies, Viral', 'Antigens, Viral', 'Capsid', 'Capsid Proteins', 'Carcinoma, Squamous Cell', 'Child', 'Epstein-Barr Virus Nuclear Antigens', 'Female', 'Herpesvirus 4, Human', 'Humans', 'Immunoglobulin A', 'Immunoglobulin G', 'Israel', 'Male', 'Middle Aged', 'Nasopharyngeal Neoplasms'... | 2,824,207 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D23.050.327'], ['A21.249.500.250'], ['D12.776.964.970.600.550'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['M01.060.406'], ['D23.050.290.249', 'D23.050.327.300'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Complete bilateral relapsing ophthalmoplegia in a diabetic patient with a sensory-motor distal polyneuropathy. | The clinicopathological study of a case of relapsing complete bilateral external ophthalmoplegia associated with a sensory-motor polyneuropathy is presented. No other causes apart from diabetes mellitus were ascertained. The sural biopsy demonstrated an axonal as well as demyelinating neuropathy. The physiopathology of... | ['Aged', 'Biopsy', 'Diabetes Mellitus, Type 2', 'Diabetic Neuropathies', 'Female', 'Humans', 'Movement Disorders', 'Ophthalmoplegia', 'Recurrence', 'Sensation', 'Sural Nerve'] | 3,720,804 | [['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C18.452.394.750.149', 'C19.246.300'], ['C10.668.829.300', 'C19.246.099.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.662'], ['C10.292... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Motility is rate-limiting for invasion of bladder carcinoma cell lines. | Induced migration of tumor cells is generally considered to be one critical step in cancer progression to the invasive and metastatic stage. The implicit caveat of studies that show this is that other, unknown, signaling pathways and biophysical events are actually the operative rate-limiting steps, and not motility pe... | ['Calpain', 'Cell Movement', 'Enzyme Activation', 'Enzyme Inhibitors', 'Epidermal Growth Factor', 'ErbB Receptors', 'Estrenes', 'Humans', 'Isoenzymes', 'Neoplasm Invasiveness', 'Phospholipase C gamma', 'Pyrrolidinones', 'Signal Transduction', 'Tumor Cells, Cultured', 'Type C Phospholipases', 'Urinary Bladder Neoplasms'... | 11,950,593 | [['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120'], ['G04.198', 'G07.568.500.180'], ['G02.111.263', 'G03.328'], ['D27.505.519.389'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differences between asthma in young and elderly: results from the COREA study. | BACKGROUND: There has been no large-scale and comprehensive study of the differences between asthma in elderly asthmatics (EA) and non-elderly (i.e. young) asthmatics (NEA).METHODS: We performed principal component analysis (PCA) using 2067 asthmatics (434 EA and 1633 NEA) from the Korean Cohort for Reality and Evoluti... | ['Adult', 'Age Factors', 'Aged', 'Asthma', 'Bronchodilator Agents', 'Cross-Sectional Studies', 'Female', 'Forced Expiratory Volume', 'Humans', 'Male', 'Middle Aged', 'Principal Component Analysis', 'Vital Capacity'] | 23,927,852 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.370.386.700.660.230', 'G09... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A pilot study to evaluate the safety and efficacy of an oral dose of (-)-epigallocatechin-3-gallate-rich polyphenon E in patients with mild to moderate ulcerative colitis. | BACKGROUND: Green tea and its main polyphenolic component, (-)-epigallocatechin-3-gallate (EGCG), exert powerful anti-inflammatory effects that are protective against both inflammatory diseases and cancer. Research with animal and human cell lines provide plausible support for these claims. Poor absorption results in l... | ['Administration, Oral', 'Adolescent', 'Adult', 'Biological Availability', 'Catechin', 'Colitis, Ulcerative', 'Double-Blind Method', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Pilot Projects', 'Prognosis', 'Quality of Life', 'Remission Induction', 'Tea', 'Young Adult'] | 23,846,486 | [['E02.319.267.100'], ['M01.060.057'], ['M01.060.116'], ['G03.787.151', 'G07.690.725.129'], ['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['E05.318.37... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Technology, Industry, and Agricult... | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Regional structural differences across functionally parcellated Brodmann areas of human primary somatosensory cortex. | Ultra-high-field (UHF) MRI is ideally suited for structural and functional imaging of the brain. High-resolution structural MRI can be used to map the anatomical boundaries between functional domains of the brain by identifying changes related to the pattern of myelination within cortical gray matter, opening up the po... | ['Adult', 'Brain Mapping', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Physical Stimulation', 'Somatosensory Cortex', 'Touch Perception'] | 23,558,101 | [['M01.060.116'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E05.723'], ['A08.186.211.200.885.287.500.670.675', 'A08.186.211.200.885.287.500.814.906'], ['F02.463.593.894']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cigarette smoking: effect on perceptions of source credibility. | This study examined the effect of cigarette smoking on the perceptions of source credibility. A sample of smokers and nonsmokers were recruited (N = 272) and randomly assigned to view one of four versions of a photograph: male with cigarette, female with cigarette, male without cigarette, and female without cigarette. ... | ['Adult', 'Attitude', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Semantic Differential', 'Smoking'] | 2,385,728 | [['M01.060.116'], ['F01.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F02.694.663', 'F04.711.647.745'], ['F01.145.805']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Initial learning curve for robot-assisted partial nephrectomy performed by a single experienced robotic surgeon. | INTRODUCTION: The objective of this study was to evaluate the initial learning curve for robot-assisted partial nephrectomy (RAPN) using the da Vinci Xi Surgical System (Intuitive Surgical, Sunnyvale, California).METHODS: This study included the initial 65 consecutive patients with small renal tumors who had undergone ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Clinical Competence', 'Female', 'Humans', 'Kidney Neoplasms', 'Learning Curve', 'Male', 'Middle Aged', 'Nephrectomy', 'Robotic Surgical Procedures', 'Surgeons'] | 30,689,309 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['F02.784.629.529.274'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. | Rheumatic heart disease represents a leading cause of mortality caused by Group A Streptococcus (GAS) infections transmitted through the respiratory route. Although GAS infections can be treated with antibiotics these are often inadequate. An efficacious GAS vaccine holds more promise, with intranasal vaccination espec... | ['Adjuvants, Immunologic', 'Administration, Intranasal', 'Animals', 'Antibodies, Bacterial', 'Cholera Toxin', 'Drug Delivery Systems', 'Female', 'Immunoglobulin A', 'Immunoglobulin G', 'Lactic Acid', 'Lipopeptides', 'Mice', 'Nanoparticles', 'Polyglycolic Acid', 'Polylactic Acid-Polyglycolic Acid Copolymer', 'Streptococ... | 27,659,862 | [['D27.505.696.477.067'], ['E02.319.267.120.655.500'], ['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D08.811.913.400.725.115.180', 'D23.946.123.194', 'D23.946.330.150'], ['E02.319.300'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.790.651.114.619.026'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Depressive symptoms before and after elective hysterectomy. | OBJECTIVE: To examine the factors associated with depressive symptoms before and after surgery in women who undergo elective hysterectomy.DESIGN: A secondary analysis of longitudinal data from a prospective cohort study designed to understand chronic postsurgical pain in women.SETTING: One acute care hospital in southe... | ['Adult', 'Age Distribution', 'Aged', 'Cohort Studies', 'Confidence Intervals', 'Depression', 'Elective Surgical Procedures', 'Female', 'Follow-Up Studies', 'Humans', 'Hysterectomy', 'Incidence', 'Middle Aged', 'Odds Ratio', 'Ontario', 'Postoperative Period', 'Preoperative Period', 'Quality of Life', 'Retrospective Stu... | 22,273,413 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['F01.145.126.350'], ['E04.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.5... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Liver X receptor-mediated induction of cholesteryl ester transfer protein expression is selectively impaired in inflammatory macrophages. | OBJECTIVE: Cholesteryl ester transfer protein (CETP) is a target gene for the liver X receptor (LXR). The aim of this study was to further explore this regulation in the monocyte-macrophage lineage and its modulation by lipid loading and inflammation, which are key steps in the process of atherogenesis.METHODS AND RESU... | ['Animals', 'Atherosclerosis', 'Blotting, Western', 'Cell Differentiation', 'Cells, Cultured', 'Cholesterol Ester Transfer Proteins', 'Gene Expression Regulation', 'Humans', 'Inflammation', 'Lipoproteins, LDL', 'Liver X Receptors', 'Macrophages', 'Mice', 'Mice, Transgenic', 'Models, Animal', 'Monocytes', 'Orphan Nuclea... | 19,679,828 | [['B01.050'], ['C14.907.137.126.307'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.152'], ['A11.251'], ['D09.400.430.750', 'D12.776.124.197', 'D12.776.157.165', 'D12.776.395.199'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rural Area Deprivation and Hospitalizations Among Children for Ambulatory Care Sensitive Conditions. | This study examined the intersection of rurality and community area deprivation using a nine-state sample of inpatient hospitalizations among children (<18 years of age) from 2011. One state from each of the nine US census regions with substantial rural representation and varying degrees of community vulnerability was ... | ['Adolescent', 'Ambulatory Care', 'Child', 'Child, Preschool', 'Health Services Accessibility', 'Healthcare Disparities', 'Hospitalization', 'Humans', 'Infant', 'Medically Underserved Area', 'Patient Protection and Affordable Care Act', 'Social Determinants of Health', 'United States', 'Vulnerable Populations'] | 26,516,019 | [['M01.060.057'], ['E02.760.106', 'N02.421.585.106'], ['M01.060.406'], ['M01.060.406.448'], ['N04.590.374.350', 'N05.300.430'], ['N04.590.374.380', 'N05.300.493'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['N03.349.650.340', 'N05.300.450.520'], ['N03.219.521.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Immunohistochemical studies on uterine tumors. I. Invasive squamous cell carcinomas of the cervix and their precursors. | 40 invasive carcinomas and 80 preinvasive lesions of the uterine cervix were studied immunohistochemically; 40 benign lesions served as controls. On histological and immunohistochemical examination, invasive and preinvasive carcinomas were subdivided in the squamous (large cell, ectocervical) type and the reserve cell ... | ['Carcinoembryonic Antigen', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Immunoenzyme Techniques', 'Keratins', 'Neoplasm Invasiveness', 'Precancerous Conditions', 'Uterine Cervical Neoplasms'] | 1,709,284 | [['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['D05.750.078.593.450', 'D12.776.220.475.450',... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protein stability and dynamics influenced by ligands in extremophilic complexes - a molecular dynamics investigation. | In this study, we explore the structural and dynamic adaptations of the Tryptophan synthase á-subunit in a ligand bound state in psychrophilic, mesophilic and hyperthermophilic organisms at different temperatures by MD simulations. We quantify the global and local fluctuations in the 40 ns time scale by analyzing the r... | ['Hydrogen Bonding', 'Hydrophobic and Hydrophilic Interactions', 'Ligands', 'Molecular Docking Simulation', 'Molecular Dynamics Simulation', 'Principal Component Analysis', 'Protein Binding', 'Protein Stability', 'Protein Subunits', 'Proteins', 'Thermodynamics', 'Tryptophan Synthase'] | 28,737,816 | [['G02.282'], ['G02.409'], ['D27.720.470.480'], ['E05.599.595.249', 'L01.224.160.249'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['E05.318.740.562'], ['G02.111.679', 'G03.808'], ['G02.111.700'], ['D12.776.813'], ['D12.776'], ['G01.906'], ['D08.811.520.241.300.850', 'D08.811.600.896']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain - A detailed case report. | We describe a patient in whom long-term, therapeutic infusion of the selective gamma-amino-butyric acid type B (GABAB) receptor agonist, baclofen, into the cerebrospinal fluid (CSF) gave rise to three distinct varieties of memory impairment: i) repeated, short periods of severe global amnesia, ii) accelerated long-term... | ['Amnesia', 'Analgesics', 'Baclofen', 'Female', 'Humans', 'Memory, Episodic', 'Memory, Short-Term', 'Middle Aged', 'Pain', 'Retention, Psychology'] | 26,599,496 | [['C10.597.606.525.100', 'C23.888.592.604.529.100', 'F01.700.625.100', 'F03.615.200'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D02.241.081.114.500.350.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.254'], ['F02.463.425.540.407'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cell damage associated with changing the medium of mesencephalic cultures in serum-free medium is mediated via N-methyl-D-aspartate receptors. | Dopaminergic neurons from embryonic rat mesencephalon were grown in simple serum-free media. The cells develop over a period of several weeks in vitro, particularly between day 14 and day 23. Removing the culture medium and replacing it with fresh medium during this interval caused severe damage to the cultures; this d... | ['2-Amino-5-phosphonovalerate', '6-Cyano-7-nitroquinoxaline-2,3-dione', 'Animals', 'Buffers', 'Cells, Cultured', 'Culture Media', 'Dizocilpine Maleate', 'Glutamates', 'Glutamic Acid', 'Mesencephalon', 'N-Methylaspartate', 'Quinoxalines', 'Receptors, N-Methyl-D-Aspartate'] | 1,672,142 | [['D12.125.070.950.100', 'D12.125.740.025'], ['D03.633.100.857.160'], ['B01.050'], ['D27.720.470.280'], ['A11.251'], ['D27.720.470.305', 'E07.206'], ['D02.455.426.559.847.181.384.380', 'D04.615.181.384.380'], ['D12.125.067.625', 'D12.125.119.409'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['A0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of alkane tumor-promoting agents on chemically induced mutagenesis in cultured V79 Chinese hamster cells. | Linear alkanes of specific chain length between 6 and 16 carbon atoms, an aryl derivative of dodecane, and a phorbol diester were tested in a cell culture system for relative ability to enhance mutagenesis induced by a chemical carcinogen, methylazoxymethanol acetate (MAM). Mutation frequencies at the ouabain-resistanc... | ['Alkanes', 'Carcinogens', 'Cells, Cultured', 'Mutagens'] | 633,409 | [['D02.455.326.146'], ['D27.888.569.100'], ['A11.251'], ['D27.888.569.468']] | ['Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Prognostic role of morphological characteristics of the immune response in uveal melanoblastomas of various cellular types]. | Histological examinations of 508 uveal melanoblastomas revealed morphological features of cell-mediated immune response and signs of degeneration and necrosis in a large number of tumors. Both histochemical and ultrastructural studies indicated a high functional activity of lymphocytes, plasma cells, and macrophages in... | ['Humans', 'Lymphocytes', 'Melanoma', 'Microscopy, Electron', 'Prognosis', 'Sclera', 'Uveal Neoplasms'] | 6,625,934 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['E01.370.350.515.402', 'E05.595.402'], ['E01.789'], ['A09.371.784'], ['C04.588.364.978', 'C11.319.494', 'C11.941.855']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dilution of protein-surfactant complexes: a fluorescence study. | Dilution of protein-surfactant complexes is an integrated step in microfluidic protein sizing, where the contribution of free micelles to the overall fluorescence is reduced by dilution. This process can be further improved by establishing an optimum surfactant concentration and quantifying the amount of protein based ... | ['Animals', 'Anions', 'Carbonic Anhydrases', 'Cations', 'Cattle', 'Cetrimonium', 'Cetrimonium Compounds', 'Fluorescence', 'Hydrophobic and Hydrophilic Interactions', 'Micelles', 'Serum Albumin, Bovine', 'Sodium Dodecyl Sulfate', 'Surface-Active Agents', 'beta-Galactosidase'] | 23,868,358 | [['B01.050'], ['D01.248.497.158'], ['D08.811.520.241.300.150'], ['D01.248.497.300'], ['B01.050.150.900.649.313.500.380.271'], ['D02.092.877.883.111.500', 'D02.675.276.190.500'], ['D02.092.877.883.111', 'D02.675.276.190'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['G02.409'], ['D05.374', 'D26.255.560'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Temporal changes in the attitude towards smoking bans in public arenas among adults in the Capital Region of Denmark from 2007 to 2010. | AIM: The population's attitude towards smoking bans in public arenas is important for their passing, implementation and compliance. Smoking bans are believed to reduce the social acceptability of smoking, and once people experience them, public support increases--also among pre-ban sceptics. This study aimed to examine... | ['Adult', 'Aged', 'Attitude to Health', 'Denmark', 'Educational Status', 'Female', 'Health Surveys', 'Humans', 'Intention', 'Male', 'Middle Aged', 'Restaurants', 'Smoking', 'Smoking Cessation', 'Smoking Prevention', 'Time Factors', 'Tobacco Smoke Pollution', 'Workplace'] | 24,728,934 | [['M01.060.116'], ['M01.060.116.100'], ['F01.100.150', 'N05.300.150'], ['Z01.542.816.124'], ['N01.824.196'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658.650', 'F02.463.306'], ['M01.060.116.630'], ['J01.576.423.500.700', 'J03.8... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]... | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Norbenzomorphan Framework as a Novel Scaffold for Generating Sigma 2 Receptor/PGRMC1 Subtype-Selective Ligands. | A novel structural class with high affinity and subtype selectivity for the sigma 2 receptor has been discovered. Preliminary structure-affinity relationship data are presented showing that 8-substituted 1,3,4,5-tetrahydro-1,5-methanobenzazepine (norbenzomorphan) derivatives elicit modest to high selectivity for the si... | ['Animals', 'Benzazepines', 'Benzomorphans', 'Guinea Pigs', 'Ligands', 'Membrane Proteins', 'Piperazines', 'Radioligand Assay', 'Rats', 'Receptors, Progesterone', 'Receptors, sigma', 'Stereoisomerism'] | 26,915,462 | [['B01.050'], ['D03.633.100.079'], ['D03.132.577.249.106', 'D04.615.723.795.106'], ['B01.050.150.900.649.313.992.550'], ['D27.720.470.480'], ['D12.776.543'], ['D03.383.606'], ['E01.370.225.985', 'E01.370.374.650', 'E01.370.384.720', 'E05.200.985'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.826.750.765'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structures of the substrate-free and product-bound forms of HmuO, a heme oxygenase from corynebacterium diphtheriae: x-ray crystallography and molecular dynamics investigation. | Heme oxygenase catalyzes the degradation of heme to biliverdin, iron, and carbon monoxide. Here, we present crystal structures of the substrate-free, Fe(3+)-biliverdin-bound, and biliverdin-bound forms of HmuO, a heme oxygenase from Corynebacterium diphtheriae, refined to 1.80, 1.90, and 1.85 ? resolution, respectively... | ['Biliverdine', 'Binding Sites', 'Corynebacterium diphtheriae', 'Crystallography, X-Ray', 'Diphtheria', 'Heme', 'Heme Oxygenase (Decyclizing)', 'Humans', 'Hydrogen Bonding', 'Iron', 'Molecular Dynamics Simulation', 'Protein Binding', 'Protein Conformation', 'Protein Structure, Secondary', 'Water'] | 24,106,279 | [['D03.383.129.578.840.249.184.200', 'D03.633.400.909.249.184.200', 'D04.345.783.249.184.200', 'D23.767.193.184.200'], ['G02.111.570.120'], ['B03.510.024.250.150', 'B03.510.460.400.400.200.150'], ['E05.196.309.742.225'], ['C01.150.252.410.040.246.388'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Perceptions of communicative disorders: verification and specification of rater variables. | UNLABELLED: Using semantic differential scales with nine trait pairs, 600 students at three universities rated five descriptions, one depicting an individual without a disorder and four portraying individuals with communicative disorders. Statistical analyses indicated that the description with no disorder was rated as... | ['Adolescent', 'Adult', 'Communication Disorders', 'Female', 'Humans', 'Male', 'Middle Aged', 'Observer Variation', 'Semantics', 'Speech Perception', 'Stereotyping'] | 11,508,900 | [['M01.060.057'], ['M01.060.116'], ['C10.597.606.150', 'C23.888.592.604.150', 'F03.625.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['L01.559.598.745'], ['F02.463.593.071.875', 'G07.888.125.875'], ['F01.100... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma. | Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered evidence indicates that additional intermediate state(s) may exist. Here, to search for such states and decipher their underlying gene regulatory network (GRN), we studied 10 melanoma cultures using single-cell RNA sequencing (RNA-s... | ['Cell Line, Tumor', 'Cell Movement', 'Gene Expression Regulation, Neoplastic', 'Gene Regulatory Networks', 'Humans', 'Melanoma', 'Phenotype', 'RNA, Neoplasm', 'RNA-Seq', 'SOXE Transcription Factors', 'Transcription Factors', 'Transcription, Genetic'] | 32,753,671 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G05.308.370'], ['G05.360.080.689.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['G05.695'], ['D13.444.735.615'], ['E05.393.332.250', 'E05.393.760.319.500', 'E05... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Competence formation in nurse midwife students starting with obstetrical management]. | How a novice in care giving becomes an expert? Based on a qualitative approach, the authors propose lines of reflexion for formative trainers in care giving. They explore the concept of skills and use knowledge typologies. They conduct explication interviews among two groups of midwives; one group is constituted of nov... | ['Attitude of Health Personnel', 'Clinical Competence', 'Education, Nursing, Continuing', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Inservice Training', 'Nurse Midwives', 'Nursing Education Research', 'Nursing Methodology Research', 'Obstetrics', 'Palpation', 'Psychomotor Performance', 'Qualitative Research',... | 15,085,566 | [['F01.100.050', 'N05.300.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.358.212.450', 'I02.358.462.399'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.574'], ['M01.526.485.650.648.762', 'N02.360.650.648.762'], ['H01.770.644.145.390.413', 'H02.478.395.4... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Subjective and objective binge eating in relation to eating disorder symptomatology, negative affect, and personality dimensions. | OBJECTIVE: The current study explored the clinical meaningfulness of distinguishing subjective (SBE) from objective binge eating (OBE) among individuals with threshold/subthreshold bulimia nervosa (BN). We examined relations between OBEs and SBEs and eating disorder symptoms, negative affect, and personality dimensions... | ['Adolescent', 'Adult', 'Affect', 'Aged', 'Anxiety', 'Bulimia', 'Depression', 'Feeding Behavior', 'Feeding and Eating Disorders', 'Female', 'Humans', 'Middle Aged', 'Personality', 'Surveys and Questionnaires'] | 23,109,272 | [['M01.060.057'], ['M01.060.116'], ['F01.470.047'], ['M01.060.116.100'], ['F01.470.132'], ['C23.888.821.645.500'], ['F01.145.126.350'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F03.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.752'], ['E05.318.308.980', 'N05.715.360.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Delayed emergence from propofol, nitrous oxide and oxygen anesthesia--a case report]. | We report a case of delayed recovery after the termination of propofol and nitrous oxide anesthesia. On the preoperative examination hepatic dysfunction (Indocyanine green (ICG) plasma retention rate at 15 minutes of 22%) was pointed out. Anesthesia was maintained with epidural block, nitrous oxide, oxygen and propofol... | ['Aged', 'Anesthesia Recovery Period', 'Anesthesia, Epidural', 'Anesthesia, General', 'Anesthetics, Intravenous', 'Humans', 'Inactivation, Metabolic', 'Indocyanine Green', 'Liver', 'Liver Function Tests', 'Male', 'Nitrous Oxide', 'Oxygen', 'Propofol', 'Time Factors'] | 9,251,517 | [['M01.060.116.100'], ['E03.160', 'E04.614.750.055', 'N02.421.585.753.750.055'], ['E03.155.086.131'], ['E03.155.197'], ['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.171.450', 'G03.787.225.450', 'G07.690.725.225.450'], ['D03.633.100.473.400'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes. | BACKGROUND/AIMS: Liver diseases are common in the United States and often require liver transplantation; however, donated organs are limited and thus alternative sources for liver cells are in high demand. Embryonic stem cells (ESC) can provide a continuous and readily available source of liver cells. ESC differentiati... | ['Activins', 'Bone Morphogenetic Protein 2', 'Cell Differentiation', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Drug Combinations', 'Embryonic Stem Cells', 'Fibroblast Growth Factors', 'Flow Cytometry', 'Hepatocytes', 'Humans', 'Polymerase Chain Reaction', 'Research Design', 'Transcription Factors', 'Up... | 22,292,891 | [['D06.472.334.500', 'D06.472.699.009', 'D12.644.548.009', 'D12.776.395.022'], ['D12.644.276.954.200.200', 'D12.776.467.942.200.200', 'D23.529.942.200.200'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['D26.310'], ['A11.872.700.250'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.6... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Analysis of communication between blind people and Nursing students]. | Analysis of how three duos of sighted Nursing students and blind people perceived communication in free recorded interaction. It was based on Discourse Analysis with an analytic tool constituted by an interview after the communication moment and by concepts characteristic of the reference framework. The analysis proces... | ['Adult', 'Communication', 'Female', 'Humans', 'Male', 'Middle Aged', 'Students, Nursing', 'Visually Impaired Persons'] | 18,604,422 | [['M01.060.116'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.848.769.685'], ['M01.150.850']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Treatment results of intracranial germinoma as a function of the irradiated volume. | Between 1962 and 1986, 70 patients were treated with radiation for confirmed or suspected intracranial germinoma at our hospital. The diagnosis was based on histology in 30 cases, cerebrospinal fluid (CSF) cytology in 12 cases, and on clinical and radiological findings in the remaining 28 cases. The target of radiation... | ['Adolescent', 'Adult', 'Brain Neoplasms', 'Child', 'Dysgerminoma', 'Female', 'Humans', 'Male', 'Methods', 'Prognosis', 'Spinal Cord Neoplasms'] | 3,403,311 | [['M01.060.057'], ['M01.060.116'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['C04.557.465.330.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['E01.789'], ['C04.588.614.250.803', 'C10.228.854.765', 'C10.551.240.750']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution. | Exotoxin A of Pseudomonas aeruginosa is a secreted bacterial toxin capable of translocating a catalytic domain into mammalian cells and inhibiting protein synthesis by the ADP-ribosylation of cellular elongation factor 2. The protein is a single polypeptide chain of 613 amino acids. The x-ray crystallographic structure... | ['ADP Ribose Transferases', 'Bacterial Toxins', 'Biological Transport', 'Carrier Proteins', 'Enzyme Precursors', 'Exotoxins', 'Models, Molecular', 'Nucleotidyltransferases', 'Poly(ADP-ribose) Polymerases', 'Protein Conformation', 'Pseudomonas aeruginosa', 'Receptors, Cell Surface', 'Receptors, Cholinergic', 'Solubility... | 3,006,045 | [['D08.811.913.400.725.115'], ['D23.946.123'], ['G03.143'], ['D12.776.157'], ['D08.622', 'D12.776.811.243'], ['D23.946.350'], ['E05.599.595'], ['D08.811.913.696.445'], ['D08.811.913.400.725.115.690'], ['G02.111.570.820.709'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['D12.776.543.750'], ['D12.776.543... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maximal blood flow after exercise in patients with intermittent claudication and in normal controls. | In some patients with intermittent claudication blood flow to the calf muscles after exercise was in the same range as in normals. The blood pressure was lower in all patients. The hypothesis is formulated that for these high flow patients the claudication is a result of non-uniform perfusion of the calf muscles. | ['Blood Flow Velocity', 'Exercise Test', 'Humans', 'Intermittent Claudication', 'Ischemia', 'Leg', 'Plethysmography'] | 1,529,418 | [['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.137.126.669', 'C23.888.531'], ['C23.550.513'], ['A01.378.610.500'], ['E01.370.370.610']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern. | Carnitine palmitoyltransferase and carnitine octanoyltransferase activities in brain mitochondrial fractions were approx. 3-4-fold lower than activities in liver. Estimated Km values of CPT1 and CPT2 (the overt and latent forms respectively of carnitine palmitoyltransferase) for L-carnitine were 80 microM and 326 micro... | ['Acyltransferases', 'Animals', 'Brain', 'Carnitine Acyltransferases', 'Carnitine O-Palmitoyltransferase', 'In Vitro Techniques', 'Kinetics', 'Malonyl Coenzyme A', 'Mitochondria', 'Rats', 'Rats, Inbred Strains', 'Synapses'] | 3,977,877 | [['D08.811.913.050'], ['B01.050'], ['A08.186.211'], ['D08.811.913.050.350'], ['D08.811.913.050.350.200'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['D03.633.100.759.646.138.382.300.500', 'D08.211.211.300.500', 'D13.695.667.138.382.300.500', 'D13.695.827.068.382.300.500'], ['A11.284.430.214.190.875.564', 'A11.284.83... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glucose transporters are abundant in cells with "occluding" junctions at the blood-eye barriers. | We studied the distribution of the "erythroid/brain" glucose transporter protein in the human and rat eye by immunocytochemistry with monoclonal and polyclonal antibodies to the C terminus of the human erythrocyte glucose transporter. We found intense immunocytochemical staining in the endothelium of microvessels of th... | ['Animals', 'Endothelium, Vascular', 'Epithelium', 'Eye', 'Glucose', 'Humans', 'Immunoenzyme Techniques', 'Intercellular Junctions', 'Microcirculation', 'Monosaccharide Transport Proteins', 'Rats', 'Rats, Inbred Strains'] | 2,190,218 | [['B01.050'], ['A07.015.700.500', 'A10.272.491.355'], ['A10.272'], ['A01.456.505.420', 'A09.371'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['A11.284.149.165.420'], ['G09.330.100.645'], ['D12.776.157.530.500', 'D12.776.543.585.5... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer. | BACKGROUND: Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. The aim of this study was to investigate whether patients with comorbidity had inferior outcomes i... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Chemoradiotherapy', 'Cisplatin', 'Comorbidity', 'Cranial Irradiation', 'Disease-Free Survival', 'Etoposide', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Small Cell Lung Carcinoma', 'Survival Analysis', 'Treatment... | 27,549,509 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['N05.715.350.225', 'N06.850.490.687'], ['E02.815.190'], ['E01.789.800.190', 'E05.318.740.998.300', 'N0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Asymptomatic acute bilateral epidural hematoma: results of broader indications for computed tomographic scanning of patients with minor head injuries. | The authors report the case of a patient with an apparently minor head injury in whom broader indications for computed tomographic (CT) scanning allowed the early detection and treatment of an acute bilateral extradural hematoma. CT scanning of adult patients with linear skull fractures should be done whenever possible... | ['Adolescent', 'Brain Injuries', 'Hematoma, Epidural, Cranial', 'Humans', 'Male', 'Tomography, X-Ray Computed'] | 3,173,663 | [['M01.060.057'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['C10.228.140.300.535.450.300', 'C10.900.300.837.300', 'C14.907.253.573.400.400', 'C23.550.414.838.349', 'C23.550.414.913.400', 'C26.915.300.490.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.350.810', 'E01.370.350.600.3... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diarrhea, pneumonia, and infectious disease mortality in children aged 5 to 14 years in India. | BACKGROUND: Little is known about the causes of death in children in India after age five years. The objective of this study is to provide the first ever direct national and sub-national estimates of infectious disease mortality in Indian children aged 5 to 14 years.METHODS: A verbal autopsy based assessment of 3 855 d... | ['Adolescent', 'Child', 'Child, Preschool', 'Communicable Diseases', 'Diarrhea', 'Female', 'Humans', 'India', 'Male', 'Pneumonia'] | 21,629,660 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C01.221', 'C23.550.291.531'], ['C23.888.821.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['C01.748.610', 'C08.381.677', 'C08.730.610']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Comparison of a new vasodilating beta-blocker, carvedilol, with atenolol in the treatment of mild to moderate essential hypertension. | Carvedilol is a new cardiovascular compound with the combined pharmacologic properties of nonselective beta-blockade and vasodilation. The aim of this study was to compare the safety and antihypertensive efficacy of 25 to 50 mg carvedilol once daily with 50 to 100 mg atenolol once daily in patients with mild to moderat... | ['Adolescent', 'Adrenergic beta-Antagonists', 'Adult', 'Aged', 'Atenolol', 'Blood Glucose', 'Blood Pressure', 'Carbazoles', 'Carvedilol', 'Double-Blind Method', 'Electrocardiography', 'Female', 'Heart Rate', 'Humans', 'Hypertension', 'Kidney Function Tests', 'Lipids', 'Liver Function Tests', 'Male', 'Middle Aged', 'Pro... | 7,910,028 | [['M01.060.057'], ['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['M01.060.116'], ['M01.060.116.100'], ['D02.033.100.624.698.070', 'D02.033.755.624.698.070', 'D02.092.063.624.698.070'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.633.100.473.144', 'D03.633.300.148'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Segregation and linkage analyses of dopamine-beta-hydroxylase activity. | Dopamine-beta-hydroxylase (DBH) activity in serum was measured by spectrophotometric methods in 95 persons of a large family (HGAR 2), along with 27 polymorphic markers from blood, urine and saliva. The distribution of DBH activity, after appropriate transformation and age adjustment, showed a significantly better fit ... | ['Adult', 'Chromosome Mapping', 'Dopamine beta-Hydroxylase', 'Female', 'Genetic Linkage', 'Humans', 'Male', 'Pedigree', 'Polymorphism, Genetic'] | 489,028 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
FasL expression in colorectal carcinoma and its significance in immune escape of cancer. | To study the significance of FasL expression in immune escape of colorectal carcinoma, FasL protein expression and the number of tumor infiltrating lymphocytes (TILs) in 80 specimens of colorectal carcinoma were detected by immunohistochemitry. The mRNA of FasL was measured by in situ hybridization in the consecutive t... | ['Adult', 'Aged', 'Apoptosis', 'Colorectal Neoplasms', 'Fas Ligand Protein', 'Female', 'Humans', 'Lymphocytes, Tumor-Infiltrating', 'Male', 'Membrane Glycoproteins', 'Middle Aged', 'RNA, Messenger', 'Tumor Cells, Cultured', 'Tumor Escape', 'Tumor Necrosis Factors'] | 16,711,013 | [['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D12.644.276.374.750.249', 'D12.776.395.550.312', 'D12.776.467.374.750.249', 'D12.776.543.550.312', 'D23.529.374.75... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effect of haemorrhage on gastric circulation and acid output in the dog. | Blood flow in the portal vein and the left gastric artery was measured electromagnetically and gastric mucosal perfusion was determined by pertechnetate clearance in anaesthetized dogs. Bleeding the animals to arterial pressures of 100 and 60 mmHg respectively reduced portal venous flow and markedly increased the mesen... | ['Animals', 'Dogs', 'Gastric Juice', 'Gastric Mucosa', 'Gastrointestinal Hemorrhage', 'Peptic Ulcer', 'Portal Vein', 'Regional Blood Flow', 'Stomach'] | 310,421 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Contributions of physical function and satisfaction with social roles to emotional distress in chronic pain: a Collaborative Health Outcomes Information Registry (CHOIR) study. | Individuals with chronic pain show greater vulnerability to depression or anger than those without chronic pain, and also show greater interpersonal difficulties and physical disability. The present study examined data from 675 individuals with chronic pain during their initial visits to a tertiary care pain clinic usi... | ['Activities of Daily Living', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anger', 'Chronic Pain', 'Depression', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Middle Aged', 'Patient Outcome Assessment', 'Personal Satisfaction', 'Registries', 'Role', 'Social Behavior', 'Stress, Psychological', 'Survey... | 26,230,739 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.470.093'], ['C23.888.592.612.274'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['M01.060.116.630'], ['N04.761.559.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Effects of droplet size and type of binder on the agglomerate growth mechanisms by melt agglomeration in a fluidised bed. | This study was performed in order to evaluate the effects of binder droplet size and type of binder on the agglomerate growth mechanisms by melt agglomeration in a fluidised bed granulator. Lactose monohydrate was agglomerated with melted polyethylene glycol (PEG) 3000 or Gelucire 50/13 (esters of polyethylene glycol a... | ['Fats', 'Oils', 'Particle Size', 'Pharmaceutic Aids', 'Polyethylene Glycols', 'Surface Properties', 'Technology, Pharmaceutical', 'Viscosity'] | 12,128,162 | [['D10.212'], ['D10.627'], ['G02.712'], ['D26.650', 'D27.720.744'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['G02.860'], ['E05.916', 'J01.897.836'], ['G02.930']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Impact of boarding pediatric psychiatric patients on a medical ward. | BACKGROUND AND OBJECTIVES: Psychiatric disorders account for an increasing number of pediatric hospitalizations. Due to lack of psychiatric beds, patients on involuntary psychiatric holds may be admitted to medical units. Our objectives were to evaluate the rate of admission of psychiatric patients to a medical unit, p... | ['Child', 'Counseling', 'Emergency Medical Services', 'Hospital Bed Capacity', 'Hospitalization', 'Humans', 'Mental Disorders', 'Mental Health Services', 'Patient Admission', 'Retrospective Studies'] | 24,785,553 | [['M01.060.406'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['N02.421.297'], ['N02.278.306.472'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F04.408', 'N02.421.461'], ['E02.760.400.600', 'N02.421.585.400.600'], ['E05.318.372.500.500.500', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Post-transcriptional regulation of meprin á by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP). | Meprins are multimeric proteases that are implicated in inflammatory bowel disease by both genetic association studies and functional studies in knock-out mice. Patients with inflammatory bowel disease show decreased colonic expression of meprin á, although regulation of expression, particularly under inflammatory stim... | ["3' Untranslated Regions", 'Biotinylation', 'Caco-2 Cells', 'Down-Regulation', 'ELAV Proteins', 'Gene Expression Regulation', 'Gene Silencing', 'Humans', 'Inflammation', 'Inflammatory Bowel Diseases', 'Metalloendopeptidases', 'Protein Binding', 'RNA Processing, Post-Transcriptional', 'Transfection', 'Tristetraprolin'] | 23,269,677 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['E05.601.085', 'G02.111.109', 'G03.162'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D12.776.157.725.813.500', 'D12.776.631... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HER2-targeted recombinant protein immuno-caspase-6 effectively induces apoptosis in HER2-overexpressing GBM cells in vitro and in vivo. | Glioblastoma multiforme (GBM), which is associated with a high rate of morbidity and mortality, is among the most malignant and treatment-refractory neoplasms in human adults. As GBM is highly resistant to conventional therapies, immunotherapies are a promising treatment candidate. HER2 is an attractive target for GBM ... | ['Animals', 'Apoptosis', 'CHO Cells', 'Caspase 6', 'Cricetinae', 'Cricetulus', 'Female', 'Gene Expression Regulation, Neoplastic', 'Glioblastoma', 'Humans', 'Mice', 'Receptor, ErbB-2', 'Recombinant Fusion Proteins', 'Xenograft Model Antitumor Assays'] | 27,633,091 | [['B01.050'], ['G04.146.954.035'], ['A11.251.210.200', 'A11.436.155'], ['D08.811.277.656.262.500.126.350.600', 'D08.811.277.656.300.200.126.350.600', 'D12.644.360.075.405.350.600', 'D12.776.476.075.405.350.600'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['G05.308.370... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Feeling pinched. Hospitals, docs anxious as 'provider payment cuts are pretty easy to do'. | In the aftermath of the debt-ceiling battle, providers are feeling nervous since lawmakers need to come up with another $1.5 trillion in cuts by the end of the year. "Provider payment cuts are pretty easy to do, relatively speaking. And there doesn't seem to be a clear connection in the minds of policymakers that equat... | ['Cost Control', 'Economics, Hospital', 'Health Care Reform', 'Humans', 'Medicare', 'Patient Protection and Affordable Care Act', 'Physicians', 'Politics', 'Reimbursement Mechanisms', 'United States'] | 21,882,387 | [['N03.219.151.160'], ['N03.219.262'], ['I01.655.500.608.400.285', 'I01.880.604.825.608.400.285', 'N03.349.285', 'N03.623.500.608.428.285', 'N04.590.374.285', 'N05.300.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615.696'], ['N03.219.521.576... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Poly(Vinylidene Fluoride-Trifluorethylene)/barium titanate membrane promotes de novo bone formation and may modulate gene expression in osteoporotic rat model. | Osteoporosis is a chronic disease that impairs proper bone remodeling. Guided bone regeneration is a surgical technique that improves bone defect in a particular region through new bone formation, using barrier materials (e.g. membranes) to protect the space adjacent to the bone defect. The polytetrafluorethylene membr... | ['Animals', 'Barium Compounds', 'Biocompatible Materials', 'Bone Regeneration', 'Bone Transplantation', 'Bone and Bones', 'Cathepsin K', 'Disease Models, Animal', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Hydrocarbons, Fluorinated', 'Matrix Metalloproteinase 9', 'Membranes, Artificial', 'Ost... | 27,770,393 | [['B01.050'], ['D01.103'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['G11.427.213.140', 'G16.762.150.150'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A02.835.232', 'A10.165.265'], ['D08.811.277.656.224.405', 'D08.811.277.656.262.500.156', 'D08.811.277.656.300.200.156'], ['C22.232', 'E05.598... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Triad of system applications for absorbable rigid fixation of the craniofacial skeleton. | A new generation of absorbable plating systems is used in a clinical setting. This new system represents state of the art innovation in biomaterial experimental design, demonstrating total absorption in one year, and well-achieved fixation of the skeleton. | ['Adolescent', 'Adult', 'Biocompatible Materials', 'Biodegradation, Environmental', 'Bone Plates', 'Bone Screws', 'Child, Preschool', 'Craniotomy', 'Evaluation Studies as Topic', 'Facial Bones', 'Fracture Fixation, Internal', 'Humans', 'Infant', 'Lactic Acid', 'Middle Aged', 'Polyglycolic Acid', 'Polylactic Acid-Polygl... | 9,133,853 | [['M01.060.057'], ['M01.060.116'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['M01.060.406.448'], ['E04.525.190']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
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