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Effect of zafirlukast (Accolate) on cellular mediators of inflammation: bronchoalveolar lavage fluid findings after segmental antigen challenge. | The effect of zafirlukast (Z) to alter the inflammatory response to segmental antigen challenge (SAC) was assessed by bronchoalveolar lavage (BAL) in this double-blind, placebo-controlled, two-period, crossover trial in 11 allergic asthmatic patients. Patients with asthma and positive skin tests to antigen received 7 d... | ['Adolescent', 'Adult', 'Antigens', 'Asthma', 'Bronchoalveolar Lavage Fluid', 'Cell Count', 'Cross-Over Studies', 'Double-Blind Method', 'Eosinophil-Derived Neurotoxin', 'Eosinophils', 'Female', 'Histamine Release', 'Humans', 'Inflammation Mediators', 'Leukotriene Antagonists', 'Leukotrienes', 'Macrophages, Alveolar', ... | 9,603,112 | [['M01.060.057'], ['M01.060.116'], ['D23.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E05.927.100.500'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.318.370.300', 'E05.581.500.300', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Nutritional fetal rickets. A case report]. | We report the case of a newborn who showed typical signs of rickets at birth craniotabes and severe hypocalcemia. The diagnosis of fetal rickets was confirmed by radiography. Maternal deficiency was revealed by an excessively low vitamin D level. The multiparous Moroccan mother had suffered low back pain and paraesthes... | ['Adult', 'Female', 'Humans', 'Infant Nutrition Disorders', 'Infant, Newborn', 'Male', 'Pregnancy', 'Pregnancy Complications', 'Radiography', 'Rickets', 'Vitamin D Deficiency'] | 9,509,328 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.422'], ['M01.060.703.520'], ['G08.686.784.769'], ['C13.703'], ['E01.370.350.700'], ['C05.116.198.816', 'C18.452.104.816', 'C18.452.174.845', 'C18.654.521.500.133.770.734'], ['C18.654.521.500.133.770']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A Mixed-Signal VLSI System for Producing Temporally Adapting Intraspinal Microstimulation Patterns for Locomotion. | Neural pathways can be artificially activated through the use of electrical stimulation. For individuals with a spinal cord injury, intraspinal microstimulation, using electrical currents on the order of 125 ì A, can produce muscle contractions and joint torques in the lower extremities suitable for restoring walking. ... | ['Animals', 'Cats', 'Electric Stimulation', 'Electrodes, Implanted', 'Equipment Design', 'Locomotion', 'Models, Biological', 'Spinal Cord Injuries', 'Transistors, Electronic'] | 26,978,832 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.402'], ['E07.305.250.319', 'E07.695.202'], ['E05.320'], ['G07.568.500', 'G11.427.410.568'], ['E05.599.395'], ['C10.228.854.763', 'C10.900.850', 'C26.819'], ['E07.305.625.714']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Familial and sporadic breast cancer cases in Iceland: a comparison related to ABO blood groups and risk of bilateral breast cancer. | This study was aimed at determining whether the familial clustering often observed in breast cancer is associated with genetic factors. We compared familial and sporadic breast cancer cases with respect to ABO blood group distribution and the risk of bilateral disease, using the data from the Icelandic Cancer Registry ... | ['ABO Blood-Group System', 'Adult', 'Aged', 'Breast Neoplasms', 'Female', 'Humans', 'Iceland', 'Middle Aged', 'Risk Factors'] | 3,170,024 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.816.249', 'Z01.639.490'], ['M01.060.116.630'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Inhibition of diazepam metabolism in microsomal- and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam. | Hydroxylated metabolites of diazepam can be conjugated and are therefore generally thought not to affect the metabolism of diazepam. Liver microsomes, obtained from phenobarbital-pretreated rats, showed an inhibition of diazepam (10(-5) M) metabolism by desmethyldiazepam as well as by N-methyloxazepam or oxazepam (5 X ... | ['Animals', 'Anti-Anxiety Agents', 'Bile', 'Diazepam', 'Hydroxylation', 'In Vitro Techniques', 'Liver', 'Male', 'Microsomes, Liver', 'Nordazepam', 'Oxazepam', 'Rats', 'Rats, Inbred Strains', 'Temazepam'] | 2,863,150 | [['B01.050'], ['D27.505.696.277.950.015', 'D27.505.954.427.210.950.015', 'D27.505.954.427.700.872.015'], ['A12.200.087'], ['D03.633.100.079.080.070.216'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['E05.481'], ['A03.620'], ['A11.284.835.540.541'], ['D03.633.100.079.080.070.216.500'], ['D03.633.100.079.080.070.663'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus. | In most tissue culture cell lines tested, infection with the paramyxovirus simian virus 5 (SV5) results in very little cell death. To determine if SV5 could be used as a vector for controlled killing of tumor cells, a recombinant SV5 (rSV5-TK) was constructed to encode the herpes simplex virus thymidine kinase (TK) gen... | ['Acyclovir', 'Animals', 'Cell Death', 'Cell Line', 'Dose-Response Relationship, Drug', 'Ganciclovir', 'Genetic Therapy', 'Genetic Vectors', 'Neoplasms', 'Recombinant Proteins', 'Respirovirus', 'Simplexvirus', 'Thymidine Kinase', 'Tumor Suppressor Protein p53'] | 11,853,412 | [['D03.633.100.759.758.399.454.250'], ['B01.050'], ['G04.146'], ['A11.251.210'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.633.100.759.758.399.454.250.300'], ['E02.095.301', 'E05.393.420.301'], ['G05.360.337'], ['C04'], ['D12.776.828'], ['B04.820.480.937.600.650.700'], ['B04.280.382.100.750'], ['D08.811.913.696.620... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcatheter vessel occlusion: angiographic results versus clinical success. | A review was made of 219 transcatheter vessel occlusion procedures performed over a ten-year period for control of hemorrhage, tumor palliation, or blood supply redistribution prior to intra-arterial chemotherapy. Complete angiographic success was obtained in 85% of the procedures, with partial success in 8%; complete ... | ['Abdomen', 'Angiography', 'Catheterization', 'Embolization, Therapeutic', 'Hemorrhage', 'Humans', 'Neoplasms'] | 6,828,710 | [['A01.923.047'], ['E01.370.350.700.060', 'E01.370.370.050'], ['E02.148', 'E05.157'], ['E02.520.360', 'E02.926.500'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subclinical inflammation and chronic renal allograft injury in a randomized trial on steroid avoidance in pediatric kidney transplantation. | Steroid avoidance is safe and effective in children receiving kidney transplants in terms of graft function and survival, but the effects on allograft histology are unknown. In this multicenter trial, 130 pediatric renal transplant recipients were randomized to steroid-free (SF; n = 60) or steroid-based (SB; n = 70) im... | ['Adolescent', 'Child', 'Female', 'Graft Rejection', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Male', 'Steroids'] | 22,694,733 | [['M01.060.057'], ['M01.060.406'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['D04.210.500']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
One-carbon metabolism pathway gene variants and risk of clear cell renal cell carcinoma in a Chinese population. | BACKGROUND: One-carbon metabolism is the basement of nucleotide synthesis and the methylation of DNA linked to cancer risk. Variations in one-carbon metabolism genes are reported to affect the risk of many cancers, including renal cancer, but little knowledge about this mechanism is known in Chinese population.METHODS:... | ['Aged', 'Alleles', 'Asian Continental Ancestry Group', 'Carcinoma, Renal Cell', 'Case-Control Studies', 'China', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Kidney Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Grading', 'Neoplasm Staging', 'Odds Ratio', 'Polymorphism, Genetic'] | 24,278,388 | [['M01.060.116.100'], ['G05.360.340.024.340.030'], ['M01.686.508.200'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.252.474... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Modulation of trophoblast stem cell and giant cell phenotypes: analyses using the Rcho-1 cell model. | Trophoblast giant cells are located at the maternal-embryonic interface and have fundamental roles in the invasive and endocrine phenotypes of the rodent placenta. In this report, we describe the experimental modulation of trophoblast stem cell and trophoblast giant cell phenotypes using the Rcho-1 trophoblast cell mod... | ['Animals', 'Cell Differentiation', 'Cell Line', 'Cell Lineage', 'Cell Proliferation', 'Dimethyl Sulfoxide', 'Female', 'Giant Cells', 'Phenotype', 'Pregnancy', 'Prolactin', 'Rats', 'Rats, Sprague-Dawley', 'Stem Cells', 'T-Box Domain Proteins', 'Trophoblasts'] | 16,351,689 | [['B01.050'], ['G04.152'], ['A11.251.210'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['G04.161.750', 'G07.345.249.410.750'], ['D02.886.640.150'], ['A11.500'], ['G05.695'], ['G08.686.784.769'], ['D06.472.699.322.576.773', 'D06.472.699.631.525.525', 'D12.644.548.691.525.525'], ['B... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Short-term effects of smoking cessation on blood antioxidant parameters and paraoxonase activity in healthy asymptomatic long-term cigarette smokers. | The aim of this study was to compare short-term effects of smoking cessation on blood oxidant/antioxidant status, cholesterol levels, and paraoxonase activity. Sixteen healthy, asymptomatic long-term cigarette smokers (mean age: 35 +/- 9 yr) participated in the study in the smoking cessation program. After and before s... | ['Adult', 'Antioxidants', 'Aryldialkylphosphatase', 'Carboxyhemoglobin', 'Cardiovascular Diseases', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Humans', 'Male', 'Malondialdehyde', 'Risk Factors', 'Smoking', 'Smoking Cessation', 'Time Factors'] | 16,717,029 | [['M01.060.116'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D08.811.277.352.660.500'], ['D12.776.124.400.141', 'D12.776.422.316.762.149'], ['C14'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vitro "progression" of bovine papillomavirus-transformed cells: loss of contact sensitivity after multiple rounds of selection. | The transformed phenotype of C127 cells harboring bovine papillomavirus shuttle vector pdBPVMMT neo(342-12) was suppressed by direct contact with untransformed C127 cells. By repeated selections of rare foci developing on untransformed cell monolayers, we obtained a cellular clone of BPV transformants which formed foci... | ['Animals', 'Blotting, Southern', 'Bovine papillomavirus 1', 'Cell Line', 'Cell Transformation, Neoplastic', 'Clone Cells', 'Culture Techniques', 'DNA, Viral', 'Genes, Viral', 'Mice', 'Mice, Nude', 'Neoplasm Transplantation', 'Restriction Mapping', 'Transcription, Genetic', 'Tumor Virus Infections'] | 1,650,331 | [['B01.050'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['B04.280.210.655.200.100', 'B04.613.204.655.200.100'], ['A11.251.210'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251.353'], ['E05.481.500'], ['D13.444.308.568'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The clinical application of converting enzyme inhibitors. | Chronic blockade of the renin angiotensin system became possible when orally active inhibitors of angiotensin converting enzyme, the enzyme which catalyzes the transformation of angiotensin I into angiotensin II, were synthetized. Two compounds, captopril and enalapril, have been investigated in clinical studies. The d... | ['Angiotensin-Converting Enzyme Inhibitors', 'Drug Tolerance', 'Heart Failure', 'Humans', 'Hypertension', 'Renin', 'Renin-Angiotensin System'] | 6,315,273 | [['D27.505.519.389.745.085'], ['G07.690.773.992'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D08.811.277.656.074.500.780', 'D08.811.277.656.300.048.780', 'D08.811.277.656.837.750'], ['G03.820', 'G09.330.380.813']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Training and capacity building evaluation: Maximizing resources and results with Success Case Method. | This article describes the use of Success Case Method (Brinkerhoff, 2003) to evaluate health promotion and public health training programs. The goal of the Office Community Research and Engagement (OCRE) of the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) is to establish a stable and sustainable ... | ['Capacity Building', 'Education, Public Health Professional', 'Female', 'Health Promotion', 'Humans', 'Male', 'Models, Organizational', 'Organizational Case Studies', 'Program Evaluation', 'Puerto Rico', 'Translational Medical Research'] | 26,036,611 | [['N02.138', 'N04.452.105'], ['I02.358.556'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.670', 'N04.452.534'], ['N03.349.380.710', 'N05.715.360.455'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['Z01.107.084.900.750', 'Z01.639.880.750'], ['H01.770.644.... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Radiation therapy for esophageal cancer in Japan: results of the Patterns of Care Study 1999-2001. | PURPOSE: To describe patient characteristics and the process of radiotherapy (RT) for patients with esophageal cancer treated between 1999 and 2001 in Japan.METHODS AND MATERIALS: The Japanese Patterns of Care Study (PCS) Working Group conducted a third nationwide survey of 76 institutions. Detailed information was acc... | ['Adenocarcinoma', 'Aged', 'Carcinoma, Adenosquamous', 'Carcinoma, Squamous Cell', 'Combined Modality Therapy', 'Esophageal Neoplasms', 'Female', 'Health Care Surveys', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Radiotherapy'] | 19,735,863 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['C04.557.435.250', 'C04.557.470.200.150'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Diagnostic effectiveness of CT and MR in local staging of renal tumors]. | The aim of this paper is to study the pre-operative staging of renal tumours, comparing CT and MR, and the imaging criteria used, examining the diagnostic efficacy for each of them. Thirty-four tumours were obtained from 29 patients. All cases were studied with CT and MR. To measure diagnostic efficacy, both for each t... | ['Adult', 'Aged', 'Female', 'Humans', 'Kidney Neoplasms', 'Lymphatic Metastasis', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Preoperative Care', 'ROC Curve', 'Tomography, X-Ray Computed'] | 8,368,117 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['C04.697.650.560', 'C23.550.727.650.560'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C04.697.645', 'C23.550.727.645'... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysis of two-category data from small independent samples. | An exact probability test for the comparison of cure-rate (or any other 2-category response variable) among three treatments is presented in detail; Extension of the method to larger contingency tables is also shown. It is suggested that the exact method should be used if the sample size for a particular investigation ... | ['Abortion, Induced', 'Antinematodal Agents', 'Attitude to Health', 'Female', 'Humans', 'Necatoriasis', 'Pregnancy', 'Probability', 'Religion'] | 1,067,813 | [['E04.520.050'], ['D27.505.954.122.250.075.080'], ['F01.100.150', 'N05.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.335.508.700.775.455.683'], ['G08.686.784.769'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['K01.844']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Human granulocytic ehrlichiosis complicating early pregnancy. | BACKGROUND: The goal of this case is to review the zoonotic infection, human granulocytic ehrlichiosis, presenting with pyrexia. Case. A 22-year-old multigravid female presented to the emergency department with a painful skin rash, high fever, and severe myalgias. The patient underwent a diagnostic evaluation for zoono... | ['Abortion, Spontaneous', 'Adult', 'Anti-Bacterial Agents', 'Disseminated Intravascular Coagulation', 'Doxycycline', 'Ehrlichiosis', 'Exanthema', 'Female', 'Fever', 'Granulocytes', 'Humans', 'Missouri', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Pregnancy Trimester, First', 'Rural Population'] | 18,509,484 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.116'], ['D27.505.954.122.085'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['C01.150.252.400.054.750', 'C01.150.252.400.285', 'C01.920.930.300'], ['C17.800.257'], ['C23.888.119.344'], ['A11... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An animal model of schizophrenia based on chronic LSD administration: old idea, new results. | Many people who take LSD experience a second temporal phase of LSD intoxication that is qualitatively different, and was described by Daniel Freedman as "clearly a paranoid state." We have previously shown that the discriminative stimulus effects of LSD in rats also occur in two temporal phases, with initial effects me... | ['Akathisia, Drug-Induced', 'Animals', 'Antipsychotic Agents', 'Behavior, Animal', 'DNA-Binding Proteins', 'Disease Models, Animal', 'Dopamine Agonists', 'Gene Expression Regulation', 'Lysergic Acid Diethylamide', 'Male', 'Motor Activity', 'Nerve Tissue Proteins', 'Psychotic Disorders', 'RNA, Messenger', 'Random Alloca... | 21,352,832 | [['C10.228.662.037', 'C10.720.075', 'C23.888.592.350.600.500', 'C25.100.249', 'C25.723.705.100'], ['B01.050'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['F01.145.113'], ['D12.776.260'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D27.505.519.625.150.151', 'D27.505.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Bilateral acute angle-closure glaucoma due to an infection with Hantavirus]. | A poor general condition of patients with hemorrhagic fever and elevated creatinine should raise suspicion of a systemic infection with Hantavirus. This can often also cause ocular changes. Above all, changes of intraocular pressure, in our case bilateral acute angle-closure glaucoma, due to edema and hemorrhage in the... | ['Antibodies, Viral', 'Diagnosis, Differential', 'Female', 'Follow-Up Studies', 'Glaucoma, Angle-Closure', 'Hemorrhagic Fever with Renal Syndrome', 'Humans', 'Iris', 'Lasers, Solid-State', 'Liver Failure', 'Middle Aged', 'Ophthalmoscopy', 'Puumala virus', 'Remission, Spontaneous', 'Renal Insufficiency', 'Retinal Hemorr... | 21,327,947 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C11.525.381.056'], ['C01.925.782.147.420.400', 'C01.925.782.417.300'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Role of NAD+ and ADP-ribosylation in the maintenance of the Golgi structure. | We have investigated the role of the ADP- ribosylation induced by brefeldin A (BFA) in the mechanisms controlling the architecture of the Golgi complex. BFA causes the rapid disassembly of this organelle into a network of tubules, prevents the association of coatomer and other proteins to Golgi membranes, and stimulate... | ['Adenosine Diphosphate Ribose', 'Animals', 'Brefeldin A', 'Cell Membrane Permeability', 'Coatomer Protein', 'Cyclopentanes', 'Endoplasmic Reticulum', 'Golgi Apparatus', 'Membrane Proteins', 'NAD', 'Rats', 'Tumor Cells, Cultured'] | 9,382,860 | [['D03.633.100.759.646.138.124.070.125', 'D09.408.620.569.070.125', 'D13.695.667.138.124.070.125', 'D13.695.827.068.124.070.125', 'D13.695.827.708.070.125'], ['B01.050'], ['D02.540.576.500.875'], ['G03.143.335', 'G04.175'], ['D12.776.543.990.300.300'], ['D02.455.426.392.368.450'], ['A11.284.430.214.190.875.248'], ['A11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
BIM deficiency differentially impacts the function of kidney endothelial and epithelial cells through modulation of their local microenvironment. | The extracellular matrix (ECM) acts as a scaffold for kidney cellular organization. Local secretion of the ECM allows kidney cells to readily adapt to changes occurring within the kidney. In addition to providing structural support for cells, the ECM also modulates cell survival, migration, proliferation, and different... | ['Animals', 'Apoptosis Regulatory Proteins', 'Bcl-2-Like Protein 11', 'Capillaries', 'Cell Adhesion', 'Cell Movement', 'Cells, Cultured', 'Cellular Microenvironment', 'Collagen', 'Drug Combinations', 'Endothelial Cells', 'Epithelial Cells', 'Extracellular Matrix', 'Kidney', 'Laminin', 'Membrane Proteins', 'Mice', 'Mice... | 22,169,007 | [['B01.050'], ['D12.644.360.075', 'D12.776.476.075'], ['D12.644.360.075.323', 'D12.776.476.075.323', 'D12.776.543.116', 'D12.776.624.664.700.025'], ['A07.015.461.165'], ['G04.022'], ['G04.198', 'G07.568.500.180'], ['A11.251'], ['G04.366'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D26.310'], ['A11.436.275'], ['A11.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Soft meaning and sincerity in the family system. | The concept of "sincerity" is often dismissed as being irrelevant to the understanding of families as systems, since sincerity is seen as a linear, intrapsychic construct. This paper makes the opposite argument. Much family communication involves a particular kind of "soft" meanings. Such meanings are flexible and open... | ['Communication', 'Family', 'Family Therapy', 'Humans', 'Professional-Family Relations', 'Set, Psychology'] | 6,677,523 | [['F01.145.209', 'L01.143'], ['F01.829.263', 'I01.880.853.150'], ['F04.754.864.581.273'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.550'], ['F02.463.425.838']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy. | OBJECTIVES: Interleukin 33 (IL-33) is a new member of the IL-1 family of cytokines which signals via its receptor, ST2 (IL-33R), and has an important role in Th2 and mast cell responses. This study shows that IL-33 orchestrates neutrophil migration in arthritis.METHODS AND RESULTS: Methylated bovine serum albumin (mBSA... | ['Animals', 'Antirheumatic Agents', 'Arthritis, Experimental', 'Arthritis, Rheumatoid', 'Chemotactic Factors', 'Chemotaxis, Leukocyte', 'Cytokines', 'Gene Expression Regulation', 'Humans', 'Interleukin-1 Receptor-Like 1 Protein', 'Interleukin-33', 'Interleukins', 'Macrophage Activation', 'Mice', 'Mice, Inbred BALB C', ... | 20,472,598 | [['B01.050'], ['D27.505.954.329'], ['C05.550.114.015', 'E05.598.500.249'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D23.125'], ['G04.198.424.233'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.85... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Opposing chemokine gradients control human thymocyte migration in situ. | The ordered migration of thymocytes from the cortex to the medulla is critical for the appropriate selection of the mature T cell repertoire. Most studies of thymocyte migration rely on mouse models, but we know relatively little about how human thymocytes find their appropriate anatomical niches within the thymus. Mor... | ['Animals', 'Cell Communication', 'Cell Differentiation', 'Chemotaxis, Leukocyte', 'Flow Cytometry', 'Humans', 'Mice', 'Microscopy, Fluorescence', 'Receptors, CCR7', 'Receptors, CXCR4', 'T-Lymphocyte Subsets', 'Thymocytes', 'Thymus Gland'] | 23,585,474 | [['B01.050'], ['G04.085'], ['G04.152'], ['G04.198.424.233'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of the freezing technique (nitrogen liquid vs ultrafreezer of -152 degrees C) and male-to-male variation over the semen quality in Canarian Mastiff breed dogs. | This study was carried out to assess the in vitro quality of canine semen frozen in an ultrafreezer at -152 degrees C and to evaluate the male-to-male variation of frozen semen in five male dogs of the Canarian Mastiff breed. Four ejaculates of each dog were processed individually (5% glycerol and 0.5% Equex) to reach ... | ['Animals', 'Cryopreservation', 'Dogs', 'Glycerol', 'Male', 'Nitrogen', 'Semen', 'Semen Preservation', 'Sperm Count', 'Sperm Motility', 'Temperature', 'Time Factors'] | 16,984,348 | [['B01.050'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.033.800.875.500', 'D09.853.875.500'], ['D01.268.604', 'D01.362.625'], ['A12.200.732'], ['E02.792.833.890', ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A Team-Based Online Game Improves Blood Glucose Control in Veterans With Type 2 Diabetes: A Randomized Controlled Trial. | OBJECTIVE: Rigorous evidence is lacking whether online games can improve patients' longer-term health outcomes. We investigated whether an online team-based game delivering diabetes self-management education (DSME) to patients via e-mail or mobile application (app) can generate longer-term improvements in hemoglobin A1... | ['Aged', 'Blood Glucose', 'Diabetes Mellitus, Type 2', 'Electronic Mail', 'Female', 'Games, Experimental', 'Glycated Hemoglobin A', 'Health Education', 'Humans', 'Internet', 'Male', 'Middle Aged', 'Mobile Applications', 'Treatment Outcome', 'Veterans'] | 28,790,131 | [['M01.060.116.100'], ['D09.947.875.359.448.500'], ['C18.452.394.750.149', 'C19.246.300'], ['L01.178.847.249', 'L01.559.423.906.377.333'], ['E05.385'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants. | The effect of rebamipide, a novel antiulcer compound, on Helicobacter pylori activated neutrophil dependent in vitro gastric epithelial cell injury was investigated. Luminol dependent chemiluminescence (ChL), which detects toxic oxidants from neutrophils exhibited a 12-fold increase when the bacterial suspension of H p... | ['Alanine', 'Animals', 'Anti-Ulcer Agents', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Epithelium', 'Gastric Mucosa', 'Helicobacter pylori', 'Luminescent Measurements', 'Neutrophils', 'Oxidants', 'Quinolones', 'Rabbits', 'Urease'] | 7,959,190 | [['D12.125.042'], ['B01.050'], ['D27.505.954.483.203'], ['A11.251'], ['G07.690.773.875', 'G07.690.936.500'], ['A10.272'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['E05.196.712.516'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.58... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prediction of global and local quality of CASP8 models by MULTICOM series. | Evaluating the quality of protein structure models is important for selecting and using models. Here, we describe the MULTICOM series of model quality predictors which contains three predictors tested in the CASP8 experiments. We evaluated these predictors on 120 CASP8 targets. The average correlations between predicte... | ['Computational Biology', 'Models, Molecular', 'Protein Conformation', 'Proteins', 'Sequence Analysis, Protein', 'Software'] | 19,544,564 | [['H01.158.273.180', 'L01.313.124'], ['E05.599.595'], ['G02.111.570.820.709'], ['D12.776'], ['E05.393.760.705'], ['L01.224.900']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Multiplexing of injury codes for the parallel operation of enzyme logic gates. | The development of a highly parallel enzyme logic sensing concept employing a novel encoding scheme for the determination of multiple pathophysiological conditions is reported. The new concept multiplexes a contingent of enzyme-based logic gates to yield a distinct 'injury code' corresponding to a unique pathophysiolog... | ['Animals', 'Biomarkers', 'Brain Injuries', 'Chemical and Drug Induced Liver Injury', 'Electrochemical Techniques', 'Electrodes', 'Enzymes', 'Oxidative Stress', 'Rabbits', 'Shock, Hemorrhagic', 'Soft Tissue Injuries'] | 20,617,272 | [['B01.050'], ['D23.101'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['E05.301'], ['E07.305.250'], ['D08.811'], ['G03.673', 'G07.775.750'], ['B01.050.150.900.649.313.968.700'], ['C23.550.414.980', 'C23.550.835.650'], ['C26.808']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Acute renal failure in lung transplantation: incidence, correlation with subsequent kidney disease, and prognostic value]. | OBJECTIVE: We studied the incidence of postoperative renal failure and its association with mortality in lung transplant patients in our hospital classified according to the severity of renal failure in the immediate postoperative period, and at 30 days, 6 months, and 1 year after transplantation.MATERIAL AND METHODS: ... | ['Acute Kidney Injury', 'Female', 'Humans', 'Incidence', 'Lung Transplantation', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies', 'Time Factors'] | 18,727,887 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['E04.928.600.495', 'E04.936.450.495'], ['M01.060.116.630'], ['E01.789'], ['E05.318.372.500.500.500', 'E... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients. | A stereotactic body frame with a fixation device has been developed for stereotactic radiation therapy of extracranial targets, a precision localization and positioning system in analogy with the stereotactic head frames used for intracranial targets. Results of the first 42 treated tumors in 31 patients are presented.... | ['Aged', 'Aged, 80 and over', 'Bone Neoplasms', 'Carcinoma, Hepatocellular', 'Disease Progression', 'Equipment Design', 'Female', 'Follow-Up Studies', 'Humans', 'Liver Neoplasms', 'Lung Neoplasms', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Particle Accelerators', 'Radiosurgery', 'Radiotherapy Dosage', 'Remi... | 7,576,756 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.149', 'C05.116.231'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C23.550.291.656'], ['E05.320'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fabrication of solid and hollow carbonate apatite microspheres as bone substitutes using calcite microspheres as a precursor. | Spherical carbonate apatite (CO3Ap) microspheres approximately 1 mm in diameter were fabricated by granulation of calcium hydroxide around a core followed by carbonation and phosphatization through dissolution-precipitation reaction. CO3Ap microspheres with high uniformity could not be achieved without using a core. So... | ['Apatites', 'Bone Substitutes', 'Calcium Carbonate', 'Microspheres', 'Porosity', 'Sodium Chloride'] | 22,864,207 | [['D01.029.260.700.675.374.075.025', 'D01.146.360.050', 'D01.578.122', 'D01.695.625.675.650.075.025'], ['D25.130.325', 'J01.637.051.130.325'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['E07.565'], ['G01.374.710'], ['D01.210.450.150.875', 'D01.857.650']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Manduca sexta hemolymph protease-2 (HP2) activated by HP14 generates prophenoloxidase-activating protease-2 (PAP2) in wandering larvae and pupae. | Melanization is a universal defense mechanism of insects against microbial infection. During this response, phenoloxidase (PO) is activated from its precursor by prophenoloxidase activating protease (PAP), the terminal enzyme of a serine protease (SP) cascade. In the tobacco hornworm Manduca sexta, hemolymph protease-1... | ['Animals', 'Endopeptidases', 'Fat Body', 'Gene Expression Regulation, Developmental', 'Hemocytes', 'Hemolymph', 'Insect Proteins', 'Integumentary System', 'Larva', 'Manduca', 'Melanins', 'Monophenol Monooxygenase', 'Nerve Tissue', 'Protein Isoforms', 'Pupa', 'Serine Endopeptidases', 'Signal Transduction', 'Trachea'] | 30,098,411 | [['B01.050'], ['D08.811.277.656.300'], ['A13.365'], ['G05.308.310'], ['A11.118.480', 'A15.145.229.480'], ['A13.453'], ['D12.776.093.500'], ['A17'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.131.617.720.500.500.937.650.525'], ['D12.125.072.050.875.379', 'D23.767.620'], ['D08.811.682.690.708.125.500'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surgical management of advanced gastrointestinal stromal tumors: an international multi-institutional analysis of 158 patients. | BACKGROUND: Patients with advanced gastrointestinal stromal tumors (GIST) are at high risk for recurrence after surgery. The aim of this study was to characterize outcomes of advanced GIST treated with surgery from a large multi-institutional database in the tyrosine kinase inhibitor (TKI) era.STUDY DESIGN: Patients wh... | ['Aged', 'Female', 'Gastrointestinal Stromal Tumors', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Survival Rate', 'Treatment Outcome'] | 25,065,359 | [['M01.060.116.100'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.650', 'C23.550.727.650'], ['C04.697.655', 'C23.550.727.655'], ['E01.789.625'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of reheating on the accuracy of polysulfide impressions. | Polysulfide impressions were made at 37 degrees C in two cylindrical trays of a truncated cone-shaped chromium-steel die. One tray size was used to obtain impressions with 1 mm thickness from tray to the gingival margin of the preparation, while the second tray permitted a thickness of 4 mm. Stone dies were made from i... | ['Dental Impression Materials', 'Dental Impression Technique', 'Dental Models', 'Hot Temperature', 'Sulfides'] | 2,135,346 | [['D25.339.334', 'J01.637.051.339.334'], ['E06.912.130'], ['E06.261', 'J01.897.280.500.545.129.200', 'L01.178.820.090.545.129.200'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D01.248.497.158.874', 'D01.875.350.850', 'D02.88... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
The generator site in acquired autoimmune neuromyotonia. | OBJECTIVE: To investigate the origin of ectopic activity in neuromyotonia (NMT).METHODS: We studied two patients. In addition to routine studies, we tested synchronicity of spontaneous discharges in different motor units in simultaneous recordings made with two needle electrodes in the first dorsal interosseus muscle. ... | ['Aged', 'Autoimmune Diseases', 'Electromyography', 'Evoked Potentials, Motor', 'Fasciculation', 'Humans', 'Immunoglobulins', 'Isaacs Syndrome', 'Male', 'Middle Aged', 'Muscle, Skeletal'] | 28,235,725 | [['M01.060.116.100'], ['C20.111'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.216.500.385', 'G11.561.200.500.385'], ['C10.597.613.250', 'C23.888.592.608.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485', 'D12.776.124.790.651', 'D12.776.377.715.548'], ['C05.651.392', 'C10.668.829.425'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases. | PURPOSE: We examined whether RNA expression of CD133, a surface molecule expressed on progenitors from hematopoietic and endothelial lineages, and CD146, a pan-endothelial marker, are increased in the blood of cancer patients and whether these factors correlate with patient characteristics and are predictive factors of... | ['AC133 Antigen', 'Adult', 'Aged', 'Aged, 80 and over', 'Antigens, CD', 'Biomarkers, Tumor', 'Bone Neoplasms', 'CD146 Antigen', 'Female', 'Glycoproteins', 'Humans', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplasms', 'Peptides', 'RNA, Messenger', 'Reproducibility of Results'] | 16,914,572 | [['D12.776.395.550.007', 'D12.776.543.550.023'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.101.140'], ['C04.588.149', 'C05.116.231'], ['D12.776.395.550.200.170', 'D12.776.543.550.200.140', 'D12.776.624.301.249', 'D23.050.285.439.249', 'D23.050.301.3... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of a gluteal activation protocol on sprint and drop jump performance. | BACKGROUND: This study examined the acute effect of gluteal activation exercises on 10 m sprints and drop jumps (DJ)s performed on a force sledge apparatus.METHODS: Twelve participants completed pre-tests of 10 sprints and 10 DJs with one minute recovery between sprints or jumps. For the 10 m sprints, contact, flight, ... | ['Adult', 'Analysis of Variance', 'Athletic Performance', 'Buttocks', 'Exercise', 'Exercise Test', 'Fatigue', 'Female', 'Humans', 'Male', 'Muscle Strength', 'Muscle, Skeletal', 'Plyometric Exercise', 'Resistance Training', 'Young Adult'] | 26,564,272 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['I03.450.642.845.054'], ['A01.378.610.100'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.600.425', 'G11... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Distribution of phosphodiesterase I in normal human tissues. | Phosphodiesterase I (PDE I) is an exonuclease capable of hydrolyzing a variety of phosphate ester and pyrophosphate bonds. Cell fractionation and histochemical studies in animal tissues have localized PDE I in the plasma membrane of various epithelia. This suggests a role for the enzyme in active transport. Distributio... | ['Histocytochemistry', 'Humans', 'Immunochemistry', 'Phosphodiesterase I', 'Phosphoric Diester Hydrolases', 'Reference Values'] | 3,025,290 | [['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.486', 'H01.181.122.605', 'H02.403.044.500'], ['D08.811.277.352.640.430'], ['D08.811.277.352.640'], ['E05.978.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Doxorubicin encapsulated in sterically stabilized liposomes exhibits renal and biliary clearance properties that are independent of valspodar (PSC 833) under conditions that significantly inhibit nonencapsulated drug excretion. | Coadministration of anticancer drugs and multidrug resistance modulators directed against P-glycoprotein over-expressed in tumors also results in nonspecific blockade of this drug efflux pump in excretory tissues such as the liver and kidneys. These interactions often result in impaired renal and biliary clearance for ... | ['Animals', 'Antibiotics, Antineoplastic', 'Bile', 'Cyclosporins', 'Doxorubicin', 'Drug Carriers', 'Drug Resistance, Multiple', 'Kidney', 'Liposomes', 'Male', 'Metabolic Clearance Rate', 'Rats', 'Rats, Sprague-Dawley'] | 10,537,363 | [['B01.050'], ['D27.505.954.248.106'], ['A12.200.087'], ['D04.345.566.235', 'D12.644.641.235'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D26.255.260', 'E02.319.300.380'], ['G07.690.773.984.300'], ['A05.810.453'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Regional mapping of facioscapulohumeral muscular dystrophy gene on 4q35: combined analysis of an international consortium. | Members of an international consortium for linkage analysis of the facioscapulohumeral muscular dystrophy (FSHD) gene have pooled data for joint analyses, in an attempt to determine the precise location of the FSHD gene and the order of four DNA markers on 4q35 region. Six laboratories determined a total of 3,078 genot... | ['Chromosome Mapping', 'Chromosomes, Human, Pair 4', 'Female', 'Genetic Linkage', 'Genetic Markers', 'Humans', 'Male', 'Muscular Dystrophies'] | 1,642,237 | [['E05.393.183'], ['A11.284.187.520.300.280.285', 'G05.360.162.520.300.280.285'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.651.534.500', 'C10.668.491.175.500', 'C16.320.577']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Baseline Central Visual Field Defect as a Risk Factor For NTG Progression: A 5-Year Prospective Study. | PRECIS: This 5-year follow-up study on normal-tension glaucoma (NTG) patients demonstrated that those with baseline central visual field (VF) defect progress at a more increased rate compared with those with peripheral field defect.PURPOSE: The purpose of this study was to investigate the clinical characteristics, incl... | ['Adult', 'Arterial Pressure', 'Blood Pressure', 'Disease Progression', 'Female', 'Follow-Up Studies', 'Humans', 'Intraocular Pressure', 'Low Tension Glaucoma', 'Male', 'Middle Aged', 'Optic Disk', 'Proportional Hazards Models', 'Prospective Studies', 'Risk Factors', 'Tonometry, Ocular', 'Vision Disorders', 'Visual Fie... | 31,688,446 | [['M01.060.116'], ['G09.330.380.076.347'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.550.291.656'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['C11.525.381.703', 'C11.640.225'], ['M01.060.116.630'], ['... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A two-year follow-up of children with urticaria in general practice. | A questionnaire was sent in 1984 to 97 children with urticaria, who had previously been seen in Danish general practice during a period of three months in 1982. The questionnaire included questions about provoking factors and the course of the disease. Replies were received from 79 children, 46 of whom had experienced ... | ['Adolescent', 'Child', 'Child, Preschool', 'Chronic Disease', 'Denmark', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Prognosis', 'Recurrence', 'Urticaria'] | 3,589,230 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['Z01.542.816.124'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789'], ['C23.550.291.937'], ['C17.800.862.945', 'C20.543.480.904']] | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hepatitis B and hemodialysis: the impact of universal precautions in preventing the transmission of bloodborne viruses. | A detailed description is presented of the hemodialysis treatment for 6 weeks of a patient strongly positive for hepatitis B virus ([HBV], hepatitis B surface antigen, hepatitis B e antigen, HBV DNA), which was performed without any special precautions. All 59 patients potentially exposed to the HBV-positive patient, o... | ['Adult', 'Cross Infection', 'Female', 'Hepatitis B', 'Humans', 'Netherlands', 'Renal Dialysis', 'Universal Precautions'] | 9,702,575 | [['M01.060.116'], ['C01.248', 'C23.550.291.875.500'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.651'], ['E02.870.300', 'E02.912.800'], ['N06.850.780.200.925']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Collagen degradation assays. | The biochemistry of collagen makes the assay of its degradation complex. Hidden epitopes are linear amino acid sequences that are not normally available for antibody binding when they are contained within an intact helical structure, but they become exposed once the collagen triple helix has been cleaved and denatured.... | ['Animals', 'Biological Assay', 'Cattle', 'Collagen', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Protein Processing, Post-Translational'] | 20,135,294 | [['B01.050'], ['E05.091'], ['B01.050.150.900.649.313.500.380.271'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D23.050.550'], ['G02.111.660.871.790.600', 'G02.111.691.600', 'G03.734.871.790.600', 'G05... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitative analysis of lung ultrasonography for the detection of community-acquired pneumonia: a pilot study. | BACKGROUND AND OBJECTIVE: Chest X-ray is recommended for routine use in patients with suspected pneumonia, but its use in emergency settings is limited. In this study, the diagnostic performance of a new method for quantitative analysis of lung ultrasonography was compared with bedside chest X-ray and visual lung ultra... | ['Community-Acquired Infections', 'Humans', 'Lung', 'Pilot Projects', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 25,811,032 | [['C01.234'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['E01.370.350.850']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activity. | A series of mutations in open reading frame (ORF) E5 of bovine papillomavirus type 1 has been constructed to determine whether this putative gene is required for in vitro oncogenic transformation by viral DNA. Frameshift mutations at either of two different positions located exclusively in ORF E5 cause a substantial re... | ['Amino Acid Sequence', 'Base Sequence', 'Bovine papillomavirus 1', 'Cell Transformation, Viral', 'Cloning, Molecular', 'DNA Restriction Enzymes', 'DNA, Recombinant', 'Genes, Viral', 'Oncogene Proteins, Viral', 'Oncogenes', 'Papillomaviridae'] | 3,006,073 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B04.280.210.655.200.100', 'B04.613.204.655.200.100'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['E05.393.220'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Early Intracellular Trafficking of Granulibacter bethesdensis in Human Macrophages. | Granulibacter bethesdensis is a Gram-negative bacterium that infects patients with chronic granulomatous disease (CGD), a primary immunodeficiency marked by a defect in NOX2, the phagocyte NADPH oxidase. Previous studies have shown that NOX2 is essential for killing of G. bethesdensis by neutrophils and monocytes and t... | ['Acetobacteraceae', 'Gram-Negative Bacterial Infections', 'Granulomatous Disease, Chronic', 'Humans', 'Interferon-gamma', 'Lysosome-Associated Membrane Glycoproteins', 'Macrophages', 'Membrane Glycoproteins', 'Microscopy, Electron, Transmission', 'Monocytes', 'NADPH Oxidase 2', 'NADPH Oxidases', 'Neutrophils', 'Phagoc... | 28,320,834 | [['B03.440.400.425.100', 'B03.660.050.755.050'], ['C01.150.252.400'], ['C15.378.553.774.535', 'C16.320.322.233', 'C20.673.774.535'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893'... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preferential positioning of nucleosomes on pBR322 as evaluated via Fourier transform of data from electron microscopy. | Nucleosome positioning on pBR322 DNA has been evaluated by electron microscopy visualization, after psoralen cross-linking. The distribution function of nucleosomes on pBR322 DNA has been calculated analyzing the data of the electron microscopy via Fourier transform. This function shows definite maxima, which indicate ... | ['Binding Sites', 'DNA, Circular', 'Fourier Analysis', 'Histones', 'Microscopy, Electron', 'Nucleic Acid Denaturation', 'Nucleosomes'] | 3,345,744 | [['G02.111.570.120'], ['D13.444.308.283', 'G02.111.570.820.486.212', 'G05.360.580.156'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['E01.370.350.515.402', 'E05.595.402'], ['E05.393.640', 'G02.111.603', 'G05.627'], ['A11.284.430.106.279.345.190.160.180.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Experience with silastic gel sheeting in pediatric scarring. | Silicone gel sheeting was applied to five hypertrophic scars on five pediatric outpatients at an acute care pediatric hospital. After silicone gel application, three of the five scars showed initial positive results including reduction in the scar size, reduction in the scar thickness, softening of the scar, a decrease... | ['Administration, Topical', 'Burns', 'Child', 'Child, Preschool', 'Cicatrix, Hypertrophic', 'Female', 'Gels', 'Humans', 'Male', 'Silicones', 'Skin Transplantation'] | 8,150,846 | [['E02.319.267.120'], ['C26.200'], ['M01.060.406'], ['M01.060.406.448'], ['A10.165.450.300.125', 'C23.550.355.274.505'], ['D20.280.320', 'D26.255.165.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.756.650.700', 'D05.750.900.850', 'D25.720.900.850', 'J01.637.051.720.900.850'], ['E02.095.147.725.700', 'E04... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Near Simultaneous Laser Scanning Confocal and Atomic Force Microscopy (Conpokal) on Live Cells. | Techniques available for micro- and nano-scale mechanical characterization have exploded in the last few decades. From further development of the scanning and transmission electron microscope, to the invention of atomic force microscopy, and advances in fluorescent imaging, there have been substantial gains in technolo... | ['Cell Survival', 'Enterococcus faecalis', 'Fluorescence', 'HEK293 Cells', 'Humans', 'Imaging, Three-Dimensional', 'Microscopy, Atomic Force', 'Microscopy, Confocal', 'Streptococcus mutans'] | 32,865,532 | [['G04.346'], ['B03.353.750.250.250.280', 'B03.510.550.250.250.280'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['E01.370.350.515... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Echocardiographic diastolic dysfunction and magnetic resonance infarct size in healed myocardial infarction treated with primary angioplasty. | BACKGROUND: After acute myocardial infarction (MI) the severity of diastolic dysfunction by echocardiography represents an independent prognostic marker. However, the mechanisms whereby diastolic dysfunction portends an increased risk after MI are not fully understood. We investigated the relationship between echocardi... | ['Angioplasty, Balloon', 'Contrast Media', 'Echocardiography', 'Female', 'Gadolinium', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Prognosis', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Treatment Outcome', 'Ventricular Dysfunction, Left'] | 18,422,674 | [['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['D01.268.558.362.484', 'D01.552.550.399.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Further followup: (Part IV) A case of acute loss of binocular vision and stereoscopic depth perception. | (Combined case report followup) This is a continuation of a personal report by a knowledgeable vision scientist, of the loss of binocular vision due to a major vitreous hemorrhage. Please see the initial report for further details. (Romano PE. A case of acute loss of binocular vision and stereoscopic depth perception. ... | ['Acute Disease', 'Aged', 'Depth Perception', 'Follow-Up Studies', 'Humans', 'Male', 'Perceptual Disorders', 'Vision Disorders', 'Vision, Binocular', 'Visual Acuity', 'Vitreous Hemorrhage'] | 14,653,778 | [['C23.550.291.125'], ['M01.060.116.100'], ['F02.463.593.200', 'F02.463.593.778.255'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.762', 'C23.888.592.604.764', 'F01.700.750'], ['C10.597.751.941', 'C11.966', 'C2... | ['Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Unique features in the C-terminal domain provide caltractin with target specificity. | Caltractin (centrin) is a member of the calmodulin (CaM) superfamily of EF-hand calcium-binding proteins. It is an essential component of the centrosomal structures in a wide range of organisms. Caltractin and calmodulin apparently function in distinct calcium signaling pathways despite substantial sequence similarity.... | ['Amino Acid Sequence', 'Animals', 'Binding Sites', 'Calcium-Binding Proteins', 'Calmodulin', 'Cell Cycle Proteins', 'Chlamydomonas reinhardtii', 'Chromosomal Proteins, Non-Histone', 'Hydrophobic and Hydrophilic Interactions', 'Macromolecular Substances', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Molecul... | 12,842,464 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.120'], ['D12.776.157.125'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D12.776.167'], ['B01.650.940.150.385.650'], ['D12.776.660.235', 'D12.776.664.235'], ['G02.409'], ['D05'], ['E05.196.867.519'], ['E05.599.595'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The Impact of Drying of Wild-Growing Mushrooms on the Content and Antioxidant Capacity of Water- Soluble Polysaccharides. | Water-soluble polysaccharides (WSPs) were isolated from freeze-dried and hot-air-dried fruiting bodies of five wild-growing edible species: Armillaria mellea, Lactarius deliciosus, Leccinum aurantiacum, Suillus luteus, and Boletus badius. The concentrations of WSPs ranged from 36.3 ± 0.7 mg/g dw to 105.9 ± 3.9 mg/g dw.... | ['Agaricales', 'Antioxidants', 'Basidiomycota', 'Desiccation', 'Freezing', 'Fruiting Bodies, Fungal', 'Hot Temperature', 'Polysaccharides', 'Water'] | 31,002,634 | [['B01.300.179.100'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B01.300.179'], ['E05.196.335', 'G02.176'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['A19.374'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif. | Hsp90 is an essential chaperone that is necessary for the folding, stability and activity of numerous proteins. In this study, we demonstrate that free radicals formed during oxidative stress conditions can cleave Hsp90. This cleavage occurs through a Fenton reaction which requires the presence of redox-active iron. As... | ['Amino Acid Motifs', 'HSP90 Heat-Shock Proteins', 'Homeostasis', 'Humans', 'Iron', 'K562 Cells', 'Oxidation-Reduction', 'Oxidative Stress', 'Proteolysis', 'Reactive Oxygen Species'] | 22,848,402 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D12.776.580.216.380'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['A11.251.210.190.510', 'A11.251.860.180.510', 'A11.443.240.497.480'], ['G02.700', 'G03.295.531'], ['G03.673'... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessing the chemical and biological diversity of an ion channels knowledge database. | The aim of the present work is to assess the chemical and biological diversity of ligands reported in scientific articles or patents to be active against ion channels targets. A specific query of the AurSCOPE Ion Channel knowledge database was constructed to retrieve a set of the most active non-peptide ligands tested ... | ['Animals', 'Cluster Analysis', 'Databases, Factual', 'Dose-Response Relationship, Drug', 'Drug Design', 'Humans', 'Ion Channels', 'Ligands', 'Membrane Transport Modulators', 'Molecular Structure', 'Principal Component Analysis', 'Structure-Activity Relationship'] | 18,708,748 | [['B01.050'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400', 'D12.77... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Reduction of both pro- and anti-inflammatory cytokines after 6 months of interferon beta-1a treatment of multiple sclerosis. | Treatment of multiple sclerosis (MS) with interferon beta (IFNbeta) reduces relapse rate, magnetic resonance imaging (MRI) activity and progression of disability. It has been suggested that this beneficial effect is paralleled by an inhibition of proinflammatory cytokines such as interferon gamma (IFNgamma) and tumor n... | ['Adjuvants, Immunologic', 'Adult', 'Cell Count', 'Cells, Cultured', 'Cerebrospinal Fluid', 'Cytokines', 'Dose-Response Relationship, Drug', 'Down-Regulation', 'Female', 'Follow-Up Studies', 'Humans', 'Interferon beta-1a', 'Interferon-beta', 'Interferon-gamma', 'Leukocytes, Mononuclear', 'Lymphocyte Activation', 'Male'... | 10,696,916 | [['D27.505.696.477.067'], ['M01.060.116'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['A11.251'], ['A12.207.270.210'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.690.773.875', 'G07.690.936.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E05.318.372.500.750.249',... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chorionic gonadotropin secretion is associated with an inhibition of follicular growth and an improvement in oocyte competence for in vitro maturation in the mare. | This study reports the follicular growth and oocyte competence for in vitro maturation and fertilization under the influence of circulating eCG. Three to 7 successive ultrasound-guided follicular punctures were performed on 4 pregnant mares from Day 23 until Day 75 of pregnancy and on 5 control mares whose embryonic ve... | ['Animals', 'Chorionic Gonadotropin', 'Estrogens', 'Female', 'Fertilization in Vitro', 'Horses', 'In Vitro Techniques', 'Oocytes', 'Ovarian Follicle', 'Pregnancy', 'Progesterone', 'Punctures'] | 9,510,964 | [['B01.050'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D27.505.696.399.472.277'], ['E02.875.800.750', 'E05.820.800.750'], ['B01.050.150.900.649.313.984.235.472'], ['E05.481'], ['A05.360.490.690.680', 'A11.497.497.600'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Utilisation of biochar and superabsorbent polymers for soil amendment. | The application of superabsorbent polymers (SAPs) and/or biochars to stressed lands offer solutions to several critical ecological, energy and economic challenges posed by degraded lands due to human activities. These substances are like, 'artificial humus' as they are hydrophilic and contain carboxylic groups (SAPs) w... | ['Agriculture', 'Carbon', 'Charcoal', 'Environmental Restoration and Remediation', 'Humans', 'Metals, Heavy', 'Nitrates', 'Pesticides', 'Plants', 'Soil', 'Soil Pollutants', 'Water'] | 23,738,439 | [['J01.040'], ['D01.268.150'], ['D01.268.150.150'], ['N06.230.080.600', 'N06.850.460.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556', 'D01.552.544'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['D27.720.031.700', 'D27.888.723'], ['B01.650'], ['D20.721', 'G01.311.820', 'G16.500.275.815... | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Decision support tool for used oil regeneration technologies assessment and selection. | Regeneration is the most efficient way of managing used oil. It saves money by preventing costly cleanups and liabilities that are associated with mismanagement of used oil, it helps to protect the environment and it produces a technically renewable resource by enabling an indefinite recycling potential. There are a va... | ['Algorithms', 'Conservation of Natural Resources', 'Decision Support Techniques', 'Internet', 'Oils', 'Petroleum', 'Programming Languages', 'Software', 'Waste Disposal, Fluid', 'Water Pollution', 'Water Purification', 'Water Supply'] | 16,647,207 | [['G17.035', 'L01.224.050'], ['J01.256', 'N06.230.080'], ['E05.245', 'L01.313.500.750.190'], ['L01.224.230.110.500'], ['D10.627'], ['D20.345.630', 'N06.230.132.258.630'], ['L01.224.900.780'], ['L01.224.900'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['N06.850.460.790'], ['N06.850.780.200.800.800.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Structural characterization of impurities in pioglitazone. | In the pioglitazone bulk drug three prominent impurities I-III were detected up to concentrations of 0.1% (ranging from 0.05-0.1%) by reversed phase HPLC. These impurities were isolated from enriched mother liquor samples and characterized as 5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione (I) 5-(4-fluorobenzyl)-1,3-thi... | ['Chromatography, High Pressure Liquid', 'Drug Contamination', 'Hypoglycemic Agents', 'Magnetic Resonance Spectroscopy', 'Mass Spectrometry', 'Pioglitazone', 'Spectrophotometry, Infrared', 'Spectroscopy, Fourier Transform Infrared', 'Thiazolidinediones'] | 15,587,582 | [['E05.196.181.400.300'], ['N06.850.360'], ['D27.505.696.422'], ['E05.196.867.519'], ['E05.196.566'], ['D02.886.675.933.250', 'D03.383.129.708.933.250'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E05.196.712.726.676.700', 'E05.196.867.826.676.700'], ['D02.886.675.933', 'D03.383.129.708.933']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Insulin preincubation effects on rat vessel contractile responses: role of the sarcoplasmic reticulum. | In the present work, we studied the possible mechanisms involved in the insulin-induced acceleration of ET1 contractions. We observed a shortening of the half-life needed to achieve maximal developed force (t(1/2)) at 10(-7) M ET1 in rat aortic rings preincubated for 120 min with 3 nM insulin (control 380 +/- 15 s vs. ... | ['Animals', 'Aorta', 'Caffeine', 'Calcium', 'Endothelin-1', 'Endothelium, Vascular', 'Enzyme Inhibitors', 'Hyperinsulinism', 'Insulin', 'Male', 'Protein Kinase C', 'Rats', 'Rats, Wistar', 'Sarcoplasmic Reticulum', 'Vasoconstriction'] | 11,824,480 | [['B01.050'], ['A07.015.114.056'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['A07.015.700.500', 'A10.272.491.355'], ['D27.505.519.389'], ['C18.452.394.968'], ['D06.472.699.587.200.500.625... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The generation of lucigenin chemiluminescence from the reaction of guanidino compounds with phenylglyoxal under alkaline conditions and its application. | It is shown that o-carboxyphenylglyoxal, which is converted from ninhydrin by alkali, produces a chemiluminescent lucigenin reaction under alkaline conditions when with reacted with guanidino compounds. It is also demonstrated that phenylglyoxal, which is a model compound of o-carboxyphenylglyoxal, produces a strong ch... | ['Acridines', 'Guanidines', 'Hydrogen-Ion Concentration', 'Luminescence', 'Molecular Structure', 'Phenylglyoxal', 'Reactive Oxygen Species'] | 19,571,414 | [['D03.633.300.046'], ['D02.078.370'], ['G02.300'], ['G01.358.500.505.650.665', 'G01.590.540.665', 'G01.750.250.650.665', 'G01.750.770.578.665'], ['G02.111.570', 'G02.466'], ['D02.047.644.620'], ['D01.339.431', 'D01.650.775']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Kupffer cell hyperplasia in rats intoxicated by carbon tetrachloride as demonstrated by scanning electron microscopy. | Kupffer cells were observed and counted by scanning electron microscopy (SEM) to demonstrate rat Kupffer cell hyperplasia after carbon tetrachloride (CCl4) intoxication. Kupffer cell number per 0.1 mm2 of the periportal zone (65.0 +/- 4.2) was 1.6 times of that of the central zone (41.8 +/- 4.5) in normal rats (P less ... | ['Animals', 'Carbon Tetrachloride Poisoning', 'Cell Count', 'Cell Division', 'Hyperplasia', 'Kupffer Cells', 'Male', 'Microscopy, Electron, Scanning', 'Rats', 'Rats, Inbred Strains', 'Time Factors'] | 7,173,570 | [['B01.050'], ['C25.723.177'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C23.550.444'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['E01.370.350.515.402.5... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Relation between body mass, body height and the blood picture to vital capacity in students exposed to air pollution]. | The authors examined the relationship between body mass, body height, haemogram and vital capacity in two groups of pupils exposed to long aeropollution. The first group consisted of children with low vital capacity. In the second group the spirometric test was normal. The authors found differences between these two gr... | ['Adolescent', 'Air Pollution', 'Body Height', 'Body Weight', 'Child', 'Erythrocyte Count', 'Female', 'Hematocrit', 'Hemoglobins', 'Humans', 'Male', 'Vital Capacity'] | 1,792,577 | [['M01.060.057'], ['N06.850.460.100'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['M01.060.406'], ['E01.370.225.500.195.107.330', 'E01.370.225.... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Extracellular vesicle‑delivered miR‑505‑5p, as a diagnostic biomarker of early lung adenocarcinoma, inhibits cell apoptosis by targeting TP53AIP1. | Lung adenocarcinoma (LA) is the most commonly occurring histological type of non‑small cell lung cancer. Diagnosis and treatment of LA remain a major clinical challenge. In the present study, to identify early LA biomarkers, extracellular vesicles (EVs) were separated from the plasma samples from 153 patients with LA a... | ['A549 Cells', 'Adenocarcinoma of Lung', 'Adult', 'Aged', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Biomarkers, Tumor', 'Case-Control Studies', 'Cell Line, Tumor', 'Coculture Techniques', 'Early Detection of Cancer', 'Extracellular Vesicles', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Lung Neop... | 30,864,684 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['D23.101.140'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11... | ['Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting. | Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of nosocomial infection. Whole-genome sequencing of MRSA has been used to define phylogeny and transmission in well-resourced healthcare settings, yet the greatest burden of nosocomial infection occurs in resource-restricted settings where barriers to ... | ['Adult', 'Bacterial Typing Techniques', 'Child', 'Computational Biology', 'Cross Infection', 'DNA, Bacterial', 'Disease Outbreaks', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Linear Models', 'Methicillin-Resistant Staphylococcus aureus', 'Phylogeny', 'Polymorphism, Single Nucleotide', 'Prospective Studies', '... | 25,491,771 | [['M01.060.116'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['M01.060.406'], ['H01.158.273.180', 'L01.313.124'], ['C01.248', 'C23.550.291.875.500'], ['D13.444.308.212'], ['N06.850.290'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Positive findings in preoperative testing prior to gastric banding: their real value. | AIM: Relations between laparoscopic adjustable gastric banding (LAGB), gastroesophageal reflux (GER) and hiatal hernia (HH) are controversial. In this context the role of preoperative investigations to assess upper gastrointestinal (GI) function and its impact on the approach to LAGB and outcomes remains unclear. The a... | ['Adult', 'Female', 'Gastroplasty', 'Humans', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Preoperative Care', 'Treatment Outcome', 'Young Adult'] | 24,193,284 | [['M01.060.116'], ['E02.650.500.062.750', 'E04.062.750', 'E04.210.485'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.699.500.500', 'G07.100.100.160.120.699.500.500'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Residual powders from Shochu distillation remnants induce apoptosis in human hepatoma cells via the caspase-independent pathway. | Shochu distillation remnants (SDR) are by-products in the manufacturing process of the Japanese liquor Shochu and include various useful organic compounds derived from the fermentation of grains. We have obtained valuable powder (PSDR) from freeze-dried SDR by the treatment with ethanol. In this study, we examined the ... | ['Active Transport, Cell Nucleus', 'Apoptosis', 'Apoptosis Inducing Factor', 'Carcinoma, Hepatocellular', 'Caspases', 'Cell Line, Tumor', 'Cell Nucleus', 'Cell Proliferation', 'Cytochromes c', 'Distillation', 'Hep G2 Cells', 'Humans', 'Liver Neoplasms', 'Membrane Potential, Mitochondrial', 'Mitochondria', 'Powders'] | 22,560,085 | [['G03.143.310.100', 'G03.143.700.100'], ['G04.146.954.035'], ['D08.811.682.608.047', 'D12.644.360.075.311', 'D12.776.157.687.063', 'D12.776.331.161', 'D12.776.476.075.311', 'D12.776.660.720.063'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D08.811.277.656.262.500.126', ... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chronic pain states: their relationship to impairment and disability. | Chronic pain patients (101) were assigned ratings of impairment and disability and were assessed for organic pathology and pain behavior through comprehensive testing procedures. As predicted, higher ratings of impairment and disability were significantly associated with higher levels of both physical pathology and pai... | ['Adult', 'Behavior Therapy', 'Chronic Disease', 'Disability Evaluation', 'Female', 'Humans', 'Male', 'Models, Biological', 'Pain'] | 496,602 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Systems Thinking and Leadership: How Nephrologists Can Transform Dialysis Safety to Prevent Infections. | Infections are the second leading cause of death for patients with ESKD. Despite multiple efforts, nephrologists have been unable to prevent infections in dialysis facilities. The American Society of Nephrology and the Centers for Disease Control and Prevention have partnered to create Nephrologists Transforming Dialys... | ['Ambulatory Care Facilities', 'Humans', 'Infection Control', 'Kidney Failure, Chronic', 'Leadership', 'Motivation', 'Nephrology', 'Organizational Culture', 'Renal Dialysis', 'Systems Analysis'] | 29,567,864 | [['N02.278.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.450'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['F01.752.609'], ['F01.658', 'F01.752.543.500.750'], ['H02.403.429.580'], ['N04.452.606'], ['E02.870.300', 'E02.912.800'], ['L01.906']] | ['Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Mutation of a zinc-binding residue in the glycine receptor á1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo. | Ethanol is a widely used drug, yet an understanding of its sites and mechanisms of action remains incomplete. Among the protein targets of ethanol are glycine receptors (GlyRs), which are potentiated by millimolar concentrations of ethanol. In addition, zinc ions also modulate GlyR function, and recent evidence suggest... | ['Acoustic Stimulation', 'Alcohol Drinking', 'Amino Acid Substitution', 'Animals', 'Behavior, Animal', 'Binding Sites', 'Electrophysiological Phenomena', 'Ethanol', 'Female', 'Gene Knock-In Techniques', 'Homozygote', 'Male', 'Mice', 'Mice, Mutant Strains', 'Models, Molecular', 'Mutagenesis, Site-Directed', 'Oocytes', '... | 23,230,213 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['F01.145.317.269'], ['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['F01.145.113'], ['G02.111.570.120'], ['G07.265'], ['D02.033.375'], ['E05.393.335.249'], ['G05.380.554'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Life span of erythrocytes in late pregnancy. | OBJECTIVE: Based on previous studies that demonstrated lighter and larger erythrocytes in late pregnancy, we hypothesized that the life span of erythrocytes in late pregnancy is shorter than in nonpregnant women.METHODS: We used the density distribution of cells to evaluate the age distribution of erythrocytes in pregn... | ['Adult', 'Animals', 'Erythrocyte Aging', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Trimester, Third', 'Rats'] | 1,603,481 | [['M01.060.116'], ['B01.050'], ['G04.043.260', 'G09.188.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['G08.686.707.520'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Engineering ribosomal leaky scanning and upstream open reading frames for precise control of protein translation. | We have employed upstream open reading frames (uORFs) to systematically tune the translation levels of recombinant proteins. We present the design principles that guided the development of this technology and provide information that may help others in implementing synthetic uORFs for their own applications. We also re... | ['Activating Transcription Factor 4', 'Animals', 'Base Sequence', 'Cell Line', 'Cricetinae', 'Gene Expression Regulation', 'Genes, Reporter', 'Genetic Engineering', 'Green Fluorescent Proteins', 'Humans', 'Molecular Sequence Data', 'Open Reading Frames', 'Peptide Chain Initiation, Translational', 'Promoter Regions, Gen... | 24,637,490 | [['D12.776.260.108.061.937', 'D12.776.930.127.061.937'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['G05.308'], ['G05.360.340.024.340.435'], ['E05.393.420'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Consequences of lithotripter shockwave interaction with gas body contrast agent in mouse intestine. | PURPOSE: Shockwave lithotripsy can involve complications associated with hemorrhage and internal bleeding which appear to be due to acoustic cavitation. Gas-body-based contrast agents recently developed for diagnostic ultrasound can enhance cavitational bioeffects under some conditions. This study examined the occurren... | ['Albumins', 'Animals', 'Contrast Media', 'Gases', 'Gastrointestinal Hemorrhage', 'Intestines', 'Lithotripsy', 'Mice', 'Mice, Hairless', 'Ultrasonography'] | 10,411,095 | [['D12.776.034'], ['B01.050'], ['D27.505.259.500', 'D27.720.259'], ['D01.362'], ['C06.405.227', 'C23.550.414.788'], ['A03.556.124'], ['E02.600', 'E04.943.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.200', 'B01.050.150.900.649.313.992.635.505.500.400.200', 'B01.050.150.900.649.313.992.63... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A surgical method in the complex treatment of metastatic bone tumors]. | The article deals with the results of operations applied in the system of complex treatment of 83 patients (86 operations) with metastases of malignant tumours in the skeletal bones. Fourteen patient had carcinoma of the lung, 23--carcinoma of the breast, 28--carcinoma of the kidney, 8--carcinoma of the thyroid gland, ... | ['Amputation', 'Artificial Limbs', 'Bone Neoplasms', 'Breast Neoplasms', 'Female', 'Femoral Neoplasms', 'Humans', 'Kidney Neoplasms', 'Laminectomy', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Prognosis', 'Ribs', 'Spinal Neoplasms', 'Thoracic Vertebrae'] | 1,469,875 | [['E04.555.080'], ['E07.695.050', 'E07.858.082.050', 'E07.858.442.050'], ['C04.588.149', 'C05.116.231'], ['C04.588.180', 'C17.800.090.500'], ['C04.588.149.276', 'C05.116.231.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis. | Allergic bronchopulmonary aspergillosis (ABPA) may complicate 1% to 2% of all cases of chronic asthma. Twenty-eight patients fulfilling the diagnostic criteria for ABPA but without evidence of proximal bronchiectasis [ABPA-S (seropositive)] were identified over a 12-year period and classified by stage. The majority of ... | ['Adolescent', 'Adult', 'Antibodies, Fungal', 'Aspergillosis, Allergic Bronchopulmonary', 'Asthma', 'Bronchiectasis', 'Child, Preschool', 'Forced Expiratory Flow Rates', 'Humans', 'Immunoglobulin A', 'Immunoglobulin E', 'Immunoglobulin G', 'Middle Aged', 'Precipitin Tests', 'Prednisone', 'Radiography'] | 8,466,099 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.179', 'D12.776.124.790.651.114.179', 'D12.776.377.715.548.114.179'], ['C01.150.703.080.768.500', 'C01.150.703.534.850.500', 'C01.748.435.090', 'C08.381.472.850.500', 'C08.674.060', 'C08.730.435.090', 'C20.543.480.680.085'], ['C08.127.108', 'C08.381.495.108', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sustainable food systems for optimal planetary health. | Sustainable food systems are an important component of a planetary health strategy to reduce the threat of infectious disease, minimize environmental footprint and promote nutrition. Human population trends and dietary transition have led to growing demand for food and increasing production and consumption of meat, ami... | ['Agriculture', 'Animals', 'Animals, Wild', 'Conservation of Natural Resources', 'Diet', 'Ecosystem', 'Food Supply', 'Global Health', 'Humans', 'Infections', 'Livestock', 'Malnutrition', 'Zoonoses'] | 29,044,366 | [['J01.040'], ['B01.050'], ['B01.050.050.300'], ['J01.256', 'N06.230.080'], ['G07.203.650.240'], ['G16.500.275.157', 'N06.230.124'], ['J01.576.423.750'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01'], ['B01.050.050.116.500'], ['C18.654.521'], ['C01.973', 'C22.969']] | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Bacterial feeding nematodes ingest haemocytes in the haemocoel of the insect Galleria mellonella | Insect parasitic nematodes have acquired mechanisms to evade their host immune response for successful parasitism. Despite the importance of understanding of the evolution of evasion mechanisms from host immunity, insect immune response against non-parasitic nematodes has not been well studied. In our previous study, w... | ['Animals', 'Caenorhabditis elegans', 'Hemocytes', 'Host-Parasite Interactions', 'Immunity, Cellular', 'Larva', 'Moths'] | 31,735,173 | [['B01.050'], ['B01.050.500.500.294.400.875.660.250.250'], ['A11.118.480', 'A15.145.229.480'], ['G16.527.200.400'], ['G12.450.050.400'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.131.617.720.500.500.937.650']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glutamate metabolism by squid nerve fiber sheaths. | The extrasynaptic region of the squid giant nerve fiber exhibits neuron-Schwann cell interactions that appear to involve glutamate as a mediator. In an earlier work, it was demonstrated that the periaxonal sheaths of such nerves (where the Schwann cells are located) possess the capacity to transport glutamate. However ... | ['Animals', 'Axons', 'Decapodiformes', 'Glutamates', 'Myelin Sheath', 'Nerve Fibers'] | 9,671,960 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['B01.050.500.644.116.150'], ['D12.125.067.625', 'D12.125.119.409'], ['A08.637.600.500', 'A08.637.800.500', 'A08.675.542.512.560', 'A08.800.800.690.500', 'A10.755.503', 'A11.284.149.165.600', 'A11.650.600.500', 'A11.650.800.500', 'A... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Crystal structure and catecholase-like activity of a mononuclear complex [Cu(EDTB)]2+ (EDTB=N,N,N',N'-tetrakis(2'-benzimidazolyl methyl)-1,2-ethanediamine). | The crystal structure and catecholase-like activity of a mononuclear complex, Cu(EDTB)(NO3)2.C2H5OH (here EDTB stands N,N,N',N'-tetrakis(2'-benzimidazolyl methyl)-1,2-ethanediamine) has been studied in comparison with a binuclear complex Cu2(EDTB)(NO3)4.3H2O. The results show that the reactive rate constants increase w... | ['Animals', 'Benzoquinones', 'Catechol Oxidase', 'Catechols', 'Copper', 'Crystallography, X-Ray', 'Diamines', 'Humans', 'Molecular Conformation', 'Molecular Structure', 'Oxidation-Reduction', 'Sorbic Acid'] | 15,271,507 | [['B01.050'], ['D02.806.250'], ['D08.811.682.690.708.125'], ['D02.455.426.559.389.657.166'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.196.309.742.225'], ['D02.092.782.258'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.820'], ['G02.111.570', 'G02.466'], ['G02.700', 'G03.295.531... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrical activity in embryonic heart cell aggregates. Developmental aspects. | Action potential parameters were measured in beating heart cell aggregates which were formed from trypsin-dissociated cells of embryonic chick heats aged 2 1/2, 4 or 7 days. 1. In aggregates composed of cells from the whole heart there was an increase in the maximum diastolic potential, overshoot, maximum rate of rise ... | ['Action Potentials', 'Age Factors', 'Animals', 'Atrial Function', 'Cell Aggregation', 'Cell Membrane Permeability', 'Cells, Cultured', 'Chick Embryo', 'Epinephrine', 'Heart', 'Methyl Ethers', 'Tetrodotoxin', 'Ventricular Function', 'Verapamil'] | 1,167,962 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['G09.330.040'], ['G04.198.251'], ['G03.143.335', 'G04.175'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.55... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ability of optical imaging devices to detect early structural damage in ocular hypertension. | We evaluated the ability of functional and structural technologies to detect early damage in ocular-hypertensive (OHT) eyes with normal standard automated perimetry (SAP) in 48 normal and 130 ocular-hypertensive subjects. We found that optical imaging devices may detect early damage in the RNFL and the optic nerve head... | ['Adult', 'Aged', 'Cross-Sectional Studies', 'Diagnostic Imaging', 'Diagnostic Techniques, Ophthalmological', 'Disease Progression', 'Equipment Design', 'Humans', 'Middle Aged', 'Ocular Hypertension', 'Optic Disk', 'Optical Devices', 'Reproducibility of Results', 'Retinal Neurons', 'Time Factors', 'Young Adult'] | 20,214,046 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.370.350'], ['E01.370.380'], ['C23.550.291.656'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C11.525'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A systematic review of plant-conjugated masked mycotoxins: Occurrence, toxicology, and metabolism. | Masked mycotoxins are biologically modified phase II metabolites formed by plant defense mechanisms through glucosylation catalyzed by uridine diphosphate -glucosyltransferases. Most of the current reports focus on the occurrence of masked mycotoxins in Europe, America, Africa, and cover other geographic regions, e.g. ... | ['Animals', 'Food Contamination', 'Gastrointestinal Microbiome', 'Humans', 'Mycotoxins', 'Plants'] | 30,806,521 | [['B01.050'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.946.587'], ['B01.650']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Associations between intrusive thoughts, reality discrimination and hallucination-proneness in healthy young adults. | INTRODUCTION: People who experience intrusive thoughts are at increased risk of developing hallucinatory experiences, as are people who have weak reality discrimination skills. No study has yet examined whether these two factors interact to make a person especially prone to hallucinatory experiences. The present study ... | ['Adult', 'Cognition', 'Discrimination, Psychological', 'Female', 'Hallucinations', 'Humans', 'Male', 'Self Report', 'Students', 'Thinking', 'Young Adult'] | 25,345,759 | [['M01.060.116'], ['F02.463.188'], ['F02.463.593.257'], ['C10.597.606.762.300', 'C23.888.592.604.764.300', 'F01.700.750.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.980.500', 'N05.715.360.300.800.500', 'N06.850.520.308.980.500'], ['M01.848'], ['F02.463.785'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The human involucrin gene is transcriptionally repressed through a tissue-specific silencer element recognized by Oct-2. | Involucrin is an important marker of epithelial differentiation which expression is upregulated just after basal cells are pushed into the suprabasal layer in stratified epithelia. Several transcription factors and regulatory elements had been described as responsible for turning on the gene. However, it is evident tha... | ['Base Sequence', 'Calcium', 'Cell Line, Tumor', 'Cell Nucleus', 'Cells, Cultured', 'DNA-Binding Proteins', 'Gene Silencing', 'Host Cell Factor C1', 'Humans', 'Keratinocytes', 'Molecular Sequence Data', 'Mutation', 'Octamer Transcription Factor-1', 'Octamer Transcription Factor-2', 'Oligonucleotides', 'Promoter Regions... | 15,120,610 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.251'], ['D12.776.260'], ['G05.308.203.374'], ['D12.776.660.478', 'D12.776.930.325'], ['B01.050.150.900.649.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Clones of Streptococcus zooepidemicus from outbreaks of hemorrhagic canine pneumonia and associated immune responses. | Acute hemorrhagic pneumonia caused by Streptococcus zooepidemicus has emerged as a major disease of shelter dogs and greyhounds. S. zooepidemicus strains differing in multilocus sequence typing (MLST), protective protein (SzP), and M-like protein (SzM) sequences were identified from 9 outbreaks in Texas, Kansas, Florid... | ['Animals', 'Antigens, Bacterial', 'Cat Diseases', 'Cats', 'Disease Models, Animal', 'Disease Outbreaks', 'Dog Diseases', 'Dogs', 'Mice', 'Multilocus Sequence Typing', 'Pneumonia, Bacterial', 'Streptococcal Infections', 'Streptococcal Vaccines', 'Streptococcus equi', 'United States', 'Virulence Factors'] | 24,990,905 | [['B01.050'], ['D23.050.161'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['N06.850.290'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.225.875.150.125.457.500', 'E05.200.875.150.125.457... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
MR imaging of the flexed knee: comparison to the extended knee in delineation of meniscal lesions. | The aim of this study was to obtain MR images in the flexed-knee position and to compare the diagnostic value to the extended position in delineation of the menisci. With a mobile knee brace and a flexible surface coil, the knee joint was either fully extended or bent to a semi-flexed position (average 45 degrees of fl... | ['Adolescent', 'Adult', 'Arthroscopy', 'Female', 'Humans', 'Knee Joint', 'Magnetic Resonance Imaging', 'Male', 'Menisci, Tibial', 'Middle Aged', 'Sensitivity and Specificity', 'Tibial Meniscus Injuries'] | 11,097,414 | [['M01.060.057'], ['M01.060.116'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['E01.370.350.825.500'], ['A02.165.308.538.500', 'A02.835.583.475.590', 'A10.165.382.350.163.500'], ['M01.060.116.630'], ['E05.318.370.800', 'E05.318.740.87... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of up-regulation of NMDA receptors on cerebral O2 consumption and blood flow in rat. | We tested the hypothesis that cerebrocortical blood flow and O2 consumption would be proportional to an up-regulated number of functional N-methyl-D-aspartate (NMDA) receptors. Previous work had shown a relationship between cerebral metabolism and NMDA receptor activity. We increased the specific binding to NMDA recept... | ['Animals', 'Brain', 'Cerebrovascular Circulation', 'Dizocilpine Maleate', 'Excitatory Amino Acid Antagonists', 'Gases', 'Hemodynamics', 'Male', 'N-Methylaspartate', 'Oxygen Consumption', 'Pipecolic Acids', 'Rats', 'Rats, Inbred Strains', 'Receptors, N-Methyl-D-Aspartate', 'Up-Regulation'] | 8,883,903 | [['B01.050'], ['A08.186.211'], ['G09.330.100.159'], ['D02.455.426.559.847.181.384.380', 'D04.615.181.384.380'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['D01.362'], ['G09.330.380'], ['D12.125.067.500.400', 'D12.125.119.170.400'], ['G03.680'], ['D03.066.758', 'D03.383.621.758'], ['B01.050.150.900.649.313... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uterine artery color Doppler assisted velocimetry and perinatal outcome. | BACKGROUND: Previously, we have found uterine artery blood velocimetry performed with Doppler ultrasound without vessel visualization to be a poor predictor of perinatal outcome. The aim of this study was to ascertain whether the combination of color Doppler imaging with the method would improve its predictive value.ME... | ['Arteries', 'Blood Flow Velocity', 'Cross-Sectional Studies', 'Female', 'Fetal Death', 'Gestational Age', 'Humans', 'Laser-Doppler Flowmetry', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Outcome', 'Pregnancy, High-Risk', 'Prospective Studies', 'Reference Values', 'Ultrasonography, D... | 8,822,652 | [['A07.015.114'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C13.703.223', 'C23.550.260.585'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.475', 'E05.830.500'], ['E05.318.370.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Cancer rehabilitation in the Federal Republic of Germany--a critical review from the perspective of rehabilitation psychology]. | Against the background of a common criticism of the rehabilitation system, the situation of rehabilitation research and practice in oncology is reviewed. A lack of efforts aimed at vocational rehabilitation as well as the main emphasis in inpatient services is criticized. Till now, outpatient services as well as psycho... | ['Ambulatory Care', 'Germany, West', 'Health Services Research', 'Hospitalization', 'Humans', 'Neoplasms', 'Quality of Health Care', 'Rehabilitation, Vocational', 'Social Support'] | 1,455,290 | [['E02.760.106', 'N02.421.585.106'], ['Z01.586.350'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['N04.761', 'N05.715'], ['E02.760.169.063.500.782', 'E02.831.782', 'N02.421.784.644'], ['I01.880.853.500.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal. | Central memory (CM) CD8(+) T cells "remember" prior encounters because they maintain themselves through cell division in the absence of ongoing challenge (homeostatic self-renewal), as well as reproduce the CM fate while manufacturing effector cells during secondary Ag encounters (rechallenge self-renewal). We tested t... | ['Adoptive Transfer', 'Animals', 'Bone Marrow Cells', 'Bone Marrow Transplantation', 'CD8-Positive T-Lymphocytes', 'Clone Cells', 'Homeostasis', 'Humans', 'Immunologic Memory', 'Immunophenotyping', 'Mice', 'Mice, Knockout', 'Mice, Transgenic', 'Receptors, CXCR4', 'Signal Transduction', 'Stem Cells'] | 24,973,450 | [['E02.095.465.425.400.330.050', 'E05.478.550.520.050'], ['B01.050'], ['A11.148', 'A15.378.316'], ['E02.095.147.725.040', 'E04.936.580.040'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['A11.251.353'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhancement by tocoretinate of epidermal growth factor-induced DNA synthesis in human intestinal epithelial cells. | Tocoretinate (TR) is a hybrid compound composed of alpha-tocopherol esterified with retinoic acid. The present study was conducted to clarify whether or not TR affects DNA synthesis in a human intestinal cell line, FHs 74 Int. In these cells, addition of 10% serum resulted in an approximately 10-fold increase in DNA sy... | ['Cell Line', 'Cells, Cultured', 'DNA', 'Drug Combinations', 'Drug Synergism', 'Epidermal Growth Factor', 'Epithelial Cells', 'Epithelium', 'Humans', 'Insulin-Like Growth Factor I', 'Intestinal Mucosa', 'Recombinant Proteins', 'Stimulation, Chemical', 'Tretinoin', 'Tritium', 'Vitamin E'] | 7,924,741 | [['A11.251.210'], ['A11.251'], ['D13.444.308'], ['D26.310'], ['G07.690.773.968.477'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['A11.436'], ['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D2... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of flexible plastic film isolators in performing potentially hazardous necropsies. | A number of necropsies were performed with the body completely isolated in a flexible film isolator in order to determine the practicability of such a method in protecting the post mortem room staff from the risk of infection from the corpse. It is considered that necropsies can be carried out using such an isolator wi... | ['Autopsy', 'Infection Control', 'Patient Isolators', 'Polyvinyl Chloride', 'Risk'] | 6,404,948 | [['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['N06.850.780.200.450'], ['E07.325.755'], ['D02.455.326.271.884.533.565', 'D05.750.716.721.812', 'D25.720.327.811', 'D25.720.716.721.812', 'J01.637.051.720.716.721.812'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Computed tomography angiography validates duplex sonographic evaluation of carotid artery stenosis. | Controversy regarding the optimal preoperative evaluation for patients with carotid arterial stenosis remains controversial. We hypothesized that carotid artery area reduction measured by computed tomography angiography (CTA) would closely correlate with duplex scanning stenosis. This study was undertaken to evaluate t... | ['Aged', 'Angiography', 'Carotid Stenosis', 'Endarterectomy, Carotid', 'Humans', 'Linear Models', 'Male', 'Preoperative Care', 'Retrospective Studies', 'Sensitivity and Specificity', 'Tomography, X-Ray Computed', 'Ultrasonography, Doppler, Duplex'] | 14,570,360 | [['M01.060.116.100'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E04.100.814.456.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The relevance of reticulin stain-measured fibrosis at diagnosis in chronic myelogenous leukemia. | Although collagen myelofibrosis indicates poor prognosis in late stages of chronic myelogenous leukemia, the significance of reticulin stain-measured fibrosis in newly diagnosed patients is unknown. One hundred and thirty-eight patients with untreated or minimally treated chronic phase Philadelphia chromosome-positive ... | ['Actuarial Analysis', 'Adolescent', 'Adult', 'Aged', 'Bone Marrow', 'Female', 'Humans', 'Leukemia, Myeloid', 'Male', 'Middle Aged', 'Primary Myelofibrosis', 'Prognosis', 'Reticulin', 'Staining and Labeling'] | 2,435,399 | [['E05.318.740.100', 'N05.715.360.750.100', 'N06.850.520.830.100'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['A15.382.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539'], ['M01.060.116.630'], ['C15.378.190.636.765'], ['E01.789'], ['D05.750.078.850', 'D12.776.860.823'], ['E01.370.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genome organization of retroviruses. V. In vitro-synthesized Moloney murine leukemia viral DNA has long terminal redundancy. | Purified virions of Moloney murine leukemia virus can synthesize genome-length double-stranded DNA in vitro. Two predominant species of long DNA transcripts, with average sizes of 9.1 and 8.5 kilobases (kb) can be identified. Both species of DNA contain the negative (complementary to viral RNA) and positive (same polar... | ['Cell-Free System', 'DNA, Viral', 'Dactinomycin', 'Exonucleases', 'Genetic Code', 'Moloney murine leukemia virus', 'Nucleic Acid Heteroduplexes', 'Nucleic Acid Hybridization', 'RNA, Viral', 'Virion'] | 6,245,245 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors. | The toxicity, pharmacokinetics and antitumour effect of chlorin e6 after light irradiation were studied. The LD50 value of chlorin e6 in C3H mice is 189 +/- 9 mg kg-1 and in Wistar white rats is 113 +/- 18 mg kg-1 14 days after intraperitoneal injection. The concentration of chlorin e6 in blood, liver, kidney, spleen a... | ['Animals', 'Cell Division', 'Dose-Response Relationship, Drug', 'Female', 'Lethal Dose 50', 'Light', 'Mice', 'Mice, Inbred C3H', 'Photochemotherapy', 'Photosensitizing Agents', 'Porphyrins', 'Radiation-Sensitizing Agents', 'Rats', 'Rats, Wistar', 'Sarcoma, Experimental', 'Time Factors', 'Tissue Distribution'] | 8,014,753 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.050.150.900.649.313.992.635.50... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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