Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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A biotin interference assay highlights two different asymmetric interaction profiles for lambda integrase arm-type binding sites in integrative versus excisive recombination. | The site-specific recombinase integrase encoded by bacteriophage lambda promotes integration and excision of the viral chromosome into and out of its Escherichia coli host chromosome through a Holliday junction recombination intermediate. This intermediate contains an integrase tetramer bound via its catalytic carboxyl... | ['Attachment Sites, Microbiological', 'Bacteriophage lambda', 'Binding Sites', 'Biological Assay', 'Biotin', 'DNA Nucleotidyltransferases', 'DNA, Cruciform', 'Integrases', 'Models, Biological', 'Nucleic Acid Conformation', 'Protein Binding', 'Protein Structure, Tertiary', 'Recombination, Genetic', 'Sequence Deletion'] | 18,319,248 | [['G05.360.340.024.079'], ['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['G02.111.570.120'], ['E05.091'], ['D03.383.129.308.080', 'D08.211.096'], ['D08.811.913.696.445.308'], ['D13.444.308.295', 'G02.111.570.820.486.325', 'G05.360.580.325'], ['D08.811.739.500'], ['E05.599.395'], ['G02.111.570.820.4... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stage III ovarian tumors of low malignant potential treated with cisplatin combination therapy (a Gynecologic Oncology Group study). | By serendipity we have had the opportunity to evaluate cis-platin-based chemotherapy in ovarian tumors of low malignant potential (LMP). Optimal (less than 1 cm residual disease) FIGO stage III ovarian carcinomas were randomly assigned to treatment with cisplatin plus cyclophosphamide with or without doxorubicin on a p... | ['Adult', 'Aged', 'Cisplatin', 'Cyclophosphamide', 'Doxorubicin', 'Drug Therapy, Combination', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Staging', 'Ovarian Neoplasms', 'Prospective Studies'] | 1,869,100 | [['M01.060.116'], ['M01.060.116.100'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of the early and late stages of myelomonocytic leukemia induced by Friend helper-independent virus F-MuLV: isolation and induction of Friend myelomonocytic leukemic cell lines. | With the use of cloned helper-independent Friend leukemia virus (F-MuLV), we have induced a high incidence (approximately 70%) of myelomonocytic leukemia in mice resistant (Fv-6rr or Fv-6rs) to erythroleukemia induction by this virus. The spleen cells from these mice (DBA/2 or BALB/c X DBA/2) were found to contain a hi... | ['Animals', 'Cell Line', 'Colony-Forming Units Assay', 'Culture Media', 'Female', 'Friend murine leukemia virus', 'Hematopoiesis', 'Hematopoietic Stem Cells', 'Leukemia, Myeloid', 'Macrophages', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred DBA', 'Monocytes', 'Phytohemagglutinins', 'Spleen'] | 6,581,171 | [['B01.050'], ['A11.251.210'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['D27.720.470.305', 'E07.206'], ['B04.613.807.375.525.225', 'B04.820.650.375.525.225'], ['G04.152.825', 'G09.188.343'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['C04.557.337.539'], ['A11.329.372', 'A11.627.482', 'A11.73... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Substitutions at the P2' site of gag p17-p24 affect cleavage efficiency by HIV-1 protease. | Heptapeptide substrates containing a single amino acid substitution at the p2' position of the gag p17-p24 junction (S-Q-N-Y-P-X-V where X = G, A, L, I, F, and W) were compared as substrates for HIV-1 protease. Binding of the Ile-, Leu-, and Ala- containing peptides was about equal although hydrolysis was 20-fold lower... | ['Amino Acid Sequence', 'Endopeptidases', 'Escherichia coli', 'Gene Products, gag', 'Gene Products, pol', 'HIV Protease', 'HIV-1', 'Kinetics', 'Molecular Sequence Data', 'Oligopeptides', 'Protein Processing, Post-Translational', 'Recombinant Proteins', 'Substrate Specificity'] | 2,182,016 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D08.811.277.656.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.775.330', 'D12.776.964.775.350', 'D12.776.964.970.600.850.350'], ['D12.776.775.360', 'D12.776.964.775.375', 'D12.776.964.900.750.500', 'D12.776.964.970.600.850.375'], ['D08.811.277.656... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prenatal diagnosis for Tay-Sachs disease using chorionic villus sampling. | Prenatal diagnosis for Tay-Sachs disease was performed on 25 patients using chorionic villus sampling (CVS). Nineteen were diagnosed as normal, and six were affected. Normal villus extracts had both hexosaminidase (hex) A and B activity, as determined by Cellogel and polyacrylamide gel electrophoresis, while extracts f... | ['Amniotic Fluid', 'Biopsy', 'Cells, Cultured', 'Chorionic Villi', 'Electrophoresis', 'Electrophoresis, Polyacrylamide Gel', 'Female', 'Hexosaminidase A', 'Hexosaminidase B', 'Hexosaminidases', 'Humans', 'Pregnancy', 'Prenatal Diagnosis', 'Tay-Sachs Disease', 'Trophoblasts', 'beta-N-Acetylhexosaminidases'] | 2,933,645 | [['A12.098', 'A16.378.149'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A11.251'], ['A10.615.284.473.200', 'A16.254.750.473.200', 'A16.710.189'], ['E05.196.401', 'E05.301.300'], ['E05.196.401.402', 'E05.301.300.319'], ... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of spatial food distribution on search behavior in rats (Rattus norvegicus). | To analyze how search strategies are adapted according to the geometric distribution of food sources, the authors submitted rats to a search task in which they had to explore 9 food trays in an open field and avoid visiting already-depleted trays. Trays were spatially arranged in 4 independent configurations: a cross, ... | ['Animals', 'Appetitive Behavior', 'Cognition', 'Exploratory Behavior', 'Feeding Behavior', 'Learning', 'Male', 'Rats', 'Space Perception'] | 17,696,655 | [['B01.050'], ['F01.145.113.111'], ['F02.463.188'], ['F01.145.387', 'F01.658.370'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F02.463.425', 'F02.784.629.529'], ['B01.050.150.900.649.313.992.635.505.700'], ['F02.463.593.778']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pri-miR-34b/c rs4938723 TC heterozygote is associated with increased cancer risks: evidence from published data. | The promoter region of the microRNA pri-miR-34b/c has a potentially functional polymorphism, rs4938723, located in a typical CpG island. Studies of the association between pri-miR-34b/c rs4938723 polymorphism and risks of various cancers have had inconsistent results. We therefore conducted a meta-analysis of nine stud... | ['Alleles', 'Genetic Predisposition to Disease', 'Heterozygote', 'Humans', 'MicroRNAs', 'Odds Ratio', 'Publication Bias', 'Risk'] | 25,201,061 | [['G05.360.340.024.340.030'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.625.590', 'N06.850.520.830.600.600'], ['L01.737.813'], ['... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Evaluation of the reverse transcription-polymerase chain reaction/probe test of serum samples and immunohistochemistry of skin sections for detection of acute bovine viral diarrhea infections. | Bovine viral diarrhea viruses (BVDV) cause both acute and persistent infections. While diagnostic tests have been designed to detect animals persistently infected (PI) with BVDV, the reliability of these tests in detecting acute BVDV infections is not known. It is also possible that acute BVDV infections may be confuse... | ['Acute Disease', 'Animals', 'Biopsy', 'Bovine Virus Diarrhea-Mucosal Disease', 'Cattle', 'DNA Primers', 'DNA, Viral', 'Diagnosis, Differential', 'Diarrhea Virus 1, Bovine Viral', 'Diarrhea Virus 2, Bovine Viral', 'Immunohistochemistry', 'Reverse Transcriptase Polymerase Chain Reaction', 'Skin'] | 12,152,809 | [['C23.550.291.125'], ['B01.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C01.925.782.350.675.106', 'C22.196.106'], ['B01.050.150.900.649.313.500.380.271'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Case volume does not correlate with outcome after cerebral aneurysm clipping: a nationwide study in Japan. | The present study analyzed the impact of case volume on outcome after cerebral aneurysm clipping at all 382 core neurosurgical training centers certified by the Japan Neurosurgical Society. A survey requested information on all clipping surgeries for cerebral aneurysms performed during 2003. Among these centers, 369 (9... | ['Hospitals', 'Humans', 'Intracranial Aneurysm', 'Japan', 'Neurosurgical Procedures', 'Treatment Outcome'] | 17,384,490 | [['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.510.600', 'C14.907.055.635', 'C14.907.253.560.300'], ['Z01.252.474.463', 'Z01.639.595'], ['E04.525'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Deep venous thromboses of the leg. Clinical and therapeutic aspects]. | Pulmonary embolism and post-phlebitic syndromes are the most serious risks run by the patient suffering from deep venous thrombosis in the lower limbs. The prognostic of phlebitis depends on how quickly the diagnosis is made, and on the quality of treatment. There is no constant functional or physical symptom. Diagnosi... | ['Aged', 'Anticoagulants', 'Hemodilution', 'Humans', 'Middle Aged', 'Postoperative Complications', 'Prognosis', 'Pulmonary Embolism', 'Rheology', 'Thrombophlebitis', 'Ultrasonography'] | 7,111,428 | [['M01.060.116.100'], ['D27.505.954.502.119'], ['E02.514'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767'], ['E01.789'], ['C08.381.746', 'C14.907.355.350.700'], ['E05.830', 'H01.671.808'], ['C14.907.355.830.925.770', 'C14.907.617.718.788', 'C14.907.940.740.910'], ['E01.370.350.850... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Human immune response to an iron-repressible outer membrane protein of Bacteroides fragilis. | Under conditions of iron starvation, Bacteroides fragilis expresses various iron-repressible outer membrane proteins (IROMPs). A 44-kDa protein appears to be one of the major outer membrane proteins (OMPs) in B. fragilis under iron stress and plays a role in heme uptake by this bacterium. To determine whether the 44-kD... | ['Animals', 'Antibodies, Bacterial', 'Bacterial Outer Membrane Proteins', 'Bacteroides Infections', 'Bacteroides fragilis', 'Blotting, Western', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Immunoblotting', 'Iron', 'Molecular Weight', 'Rats'] | 1,879,923 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.097.120', 'D12.776.543.100'], ['C01.150.252.400.110.109'], ['B03.440.080.094.152.400', 'B03.440.425.410.194.152.400'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Longitudinal analysis of regional grey matter loss in Huntington disease: effects of the length of the expanded CAG repeat. | BACKGROUND: The mechanisms guiding the progression of neuronal damage in patients with Huntington disease (HD) are not completely understood. It is unclear whether the genotype--that is, the length of the expanded CAG repeat--guides the location and speed of grey matter decline once HD is clinically manifested. Moreove... | ['Adolescent', 'Adult', 'Aged', 'Atrophy', 'Brain', 'Child', 'Child, Preschool', 'Cohort Studies', 'DNA Repeat Expansion', 'Disease Progression', 'Female', 'Genotype', 'Humans', 'Huntington Disease', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Longitudinal Studies', 'Magnetic Resonance Imaging... | 17,615,168 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.300.070'], ['A08.186.211'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G02.111.570.080.708.800.140', 'G05.360.080.708.800.074', 'G05.360.340.024.189.220', 'G05.360.340.024.850.140', ... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Localization of carcinoembryogenic antigen (CEA) in normal, inflammatory and neoplastic colonic mucosa by immunofluorescence. | To evaluate the role of tissutal carcinoembryonic antigen (CEA) in different types of colonic mucosae specimens from normal, inflammatory and neoplastic tissues were examined in immunofluorescence (IFL) with a monospecific CEA antiserum. Neither the pattern of IFL nor the amount of antigen in the tissue (defined as the... | ['Carcinoembryonic Antigen', 'Colitis', 'Colonic Neoplasms', 'Fluorescent Antibody Technique', 'Humans', 'Intestinal Mucosa', 'Intestinal Polyps'] | 326,270 | [['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C06.405.205.265', 'C06.405.469.158.188'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E01.370.225.500... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Foam pad of appropriate thickness can improve diagnostic value of foam posturography in detecting postural instability. | OBJECTIVE: The present study investigated the effect of foam thickness on postural stability in patients with unilateral vestibular hypofunction (UVH) during foam posturography.METHODS: Static and foam posturography were performed in 33 patients (UVH group) and 30 healthy subjects (control group) with eyes open (EO) an... | ['Adult', 'Case-Control Studies', 'Diagnostic Techniques, Otological', 'Female', 'Humans', 'Male', 'Posture', 'Vestibular Diseases'] | 29,161,921 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.695'], ['C09.218.568.900']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Afforestation and deforestation enhanced soil CH4 | The impact of afforestation and deforestation on the carbon cycle and carbon sequestration in agricultural landscape has been well studied, while the direction and magnitude of the effects on soil CH4 fluxes remain uncertain in particular in the subtropical region. Thus, multi-site and multi-year field experiments were... | ['Agriculture', 'Carbon Sequestration', 'China', 'Forestry', 'Methane', 'Seasons', 'Soil'] | 30,690,366 | [['J01.040'], ['G02.607.125.500', 'G16.500.150.500'], ['Z01.252.474.164'], ['J01.576.430'], ['D02.455.326.146.571'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Attempted nonoperative management of blunt renal lacerations extending through the corticomedullary junction: the short-term and long-term sequelae. | A total of 50 patients who sustained a renal laceration extending through the corticomedullary junction following blunt trauma underwent an attempt at nonoperative (expectant) management of the urological injury. Of the patients 18% could not be stabilized and they subsequently underwent emergency laparotomy. Among our... | ['Blood Pressure', 'Humans', 'Kidney', 'Kidney Cortex', 'Kidney Medulla', 'Time Factors', 'Wounds, Nonpenetrating'] | 2,313,792 | [['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['A05.810.453.324'], ['A05.810.453.466'], ['G01.910.857'], ['C26.974']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reflections on a Community Engagement Strategy for Mass Antimalarial Drug Administration in Cambodia. | Mass drug administration (MDA) to interrupt malaria transmission requires the participation of entire communities. As part of a clinical trial in western Cambodia, four villages received MDA in 2015-2016. Before approaching study communities, a collaboration was established with the local health authorities, village le... | ['Antimalarials', 'Cambodia', 'Community Participation', 'Community-Institutional Relations', 'Humans', 'Malaria', 'Mass Drug Administration', 'Program Development'] | 29,165,227 | [['D27.505.954.122.250.100.085'], ['Z01.252.145.182'], ['N02.421.143.212', 'N03.540.245.360'], ['N04.452.822.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530', 'C01.920.875'], ['E02.319.162.575', 'N06.850.275.500', 'N06.850.780.200.600'], ['N04.452.760']] | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Prevalence of depression in Alzheimer's disease and validity of Research Diagnostic Criteria. | This study was undertaken to estimate the point-prevalence of Research Diagnostic Criteria (RDC) depressive syndromes in Alzheimer's disease (AD) and to evaluate the validity of existing and potential alternative diagnostic criteria for major depression in the presence of probable AD. Twenty-six subjects with probable ... | ['Adult', 'Age of Onset', 'Aged', 'Alzheimer Disease', 'Comorbidity', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'Prevalence', 'Psychiatric Status Rating Scales', 'Reproducibility of Results', 'Severity of Illness Index'] | 7,826,494 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['N05.715.350.225', 'N06.850.490.687'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of olfactory stimuli on arm-reaching duration. | The aim of the present study was to investigate the effects of olfactory stimuli on visually guided reaching. In Experiment 1, participants reached toward and grasped either a small (almond/strawberry) or a large (apple/orange) visual target. Any 1 of 4 odors corresponding to the visual stimuli or odorless air was admi... | ['Action Potentials', 'Adult', 'Arm', 'Female', 'Fruit', 'Humans', 'Male', 'Odorants', 'Photic Stimulation', 'Reference Values', 'Smell', 'Stimulation, Chemical'] | 18,344,564 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.116'], ['A01.378.800.075'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G16.500.275.640', 'N06.230.480'], ['E05.723.729'], ['E05.978.810'], ['F02.830.816.643', 'G11.561.790.643'], ['G07.690.773.99... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Lactation and maternal risk of diabetes: Evidence from the Mexican Teachers' Cohort. | One postpartum behaviour that may be protective against diabetes is lactation due to its potential role in resetting maternal metabolism after pregnancy. However, the role of lactation in maternal risk of diabetes has not been investigated in Latin American populations, where rates of breastfeeding are suboptimal and d... | ['Adult', 'Breast Feeding', 'Cohort Studies', 'Diabetes Mellitus, Type 2', 'Female', 'Humans', 'Lactation', 'Maternal Health', 'Mexico', 'Middle Aged', 'Surveys and Questionnaires', 'Time Factors'] | 31,343,828 | [['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C18.452.394.750.149', 'C19.246.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.523', 'G08.686.702.500'], ['N01.40... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Subconjunctival injection of XG-102, a c-Jun N-terminal kinase inhibitor peptide, in the treatment of endotoxin-induced uveitis in rats. | PURPOSE: XG-102, a TAT-coupled dextrogyre peptide inhibiting the c-Jun N-terminal kinase, was shown efficient in the treatment of experimental uveitis. Preclinical studies are now performed to determine optimal XG-102 dose and route of administration in endotoxin-induced uveitis (EIU) in rats with the purpose of clinic... | ['Animals', 'Anti-Inflammatory Agents', 'Chemokine CXCL1', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Down-Regulation', 'Female', 'Injections, Intraocular', 'Injections, Intravenous', 'Lipopolysaccharides', 'Nitric Oxide Synthase Type II', 'Peptides', 'Phosphorylation', 'Protein Kinase Inhibitors', ... | 25,313,830 | [['B01.050'], ['D27.505.954.158'], ['D12.644.276.374.200.120.050', 'D12.776.467.374.200.120.050', 'D12.776.624.664.700.049', 'D23.125.300.120.050', 'D23.469.200.120.050', 'D23.529.374.200.120.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['G02.111.240', 'G05.308.200', 'G0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Correlation between the stability constant and pH for â-cyclodextrin complexes. | In drug formulations, cyclodextrins are used to increase aqueous solubility and chemical stability of drugs via formation of inclusion complexes. For ionizable drug molecules, the complexation strength depends on pH. Increased ionization leads to a more soluble drug, but also results in destabilization of cyclodextrin ... | ['Drug Stability', 'Hydrogen-Ion Concentration', 'Ibuprofen', 'beta-Cyclodextrins'] | 31,319,150 | [['E05.916.330'], ['G02.300'], ['D02.241.223.701.430'], ['D04.345.103.333', 'D09.301.915.400.375.333', 'D09.698.365.855.400.375.333']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. | Sequence variations in a variety of pro- or anti-inflammatory cytokine genes have been found to influence successful aging and longevity. Because of the role played by the transforming growth factor beta1 (TGF-beta1) cytokine in inflammation and regulation of immune responses, the variability of the TGF-beta1 gene may ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Alleles', 'Cytokines', 'Female', 'Genotype', 'Humans', 'Italy', 'Longevity', 'Male', 'Middle Aged', 'Polymorphism, Genetic', 'Sex Characteristics', 'Transforming Growth Factor beta', 'Transforming Growth Factor beta1'] | 15,569,360 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['G05.360.340.024.340.030'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['G07.345.124.519', 'G07.540'], ['M01.060.116.630'], ['G05.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Consistent RNA sequencing contamination in GTEx and other data sets. | A challenge of next generation sequencing is read contamination. We use Genotype-Tissue Expression (GTEx) datasets and technical metadata along with RNA-seq datasets from other studies to understand factors that contribute to contamination. Here we report, of 48 analyzed tissues in GTEx, 26 have variant co-expression c... | ['DNA Contamination', 'Genotype', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Polymorphism, Single Nucleotide', 'RNA', 'Sequence Analysis, RNA', 'Single-Cell Analysis'] | 32,321,923 | [['E01.370.225.998.293', 'E05.200.998.293', 'E05.393.290.573', 'E05.393.760.700.224', 'I01.198.780.937.375.500'], ['G05.380'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.598'], ['D13.444.735'], ['E05.393.760.710'], ['E05.242.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Effect of indomethacin on arterial oxygenation in critically ill patients with severe bacterial pneumonia. | The effect of indomethacin (1 mg/kg) on gas exchange was studied in ten patients with hypoxaemic respiratory failure precipitated by bacterial pneumonia. Mean arterial oxygen tension (PaO2) improved significantly (79 +/- 16 mm Hg to 98 +/- 20 mm Hg) but the response varied between patients: five showed substantial resp... | ['Acute Disease', 'Adult', 'Aged', 'Aged, 80 and over', 'Bacterial Infections', 'Critical Care', 'Humans', 'Hypoxia', 'Indomethacin', 'Middle Aged', 'Oxygen', 'Pneumonia', 'Pulmonary Gas Exchange'] | 2,880,162 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C01.150.252'], ['E02.760.190', 'N02.421.585.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['D03.633.100.473.420'], ['M01.060.116.630'], ['D01.268.185.550', 'D01.362.670'], ['C01.748.610', 'C08.381.677',... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Mutation screening in Angiotensin II receptors, AGTR1 and AGTR2, and evaluation of AGTR1 polymorphisms C573T and A1166C in patients with premature adrenarche]. | Precocious pubarche is the appearance of pubic hair before the age of 8 years in girls and 9 years in boys. The most frequent etiology is idiopathic precocious adrenarche, suggested, after long-term follow-up, to be associated with metabolic syndrome. One of the factors involved in the genesis of precocious adrenarche ... | ['Adrenarche', 'Analysis of Variance', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Female', 'Gene Frequency', 'Genotype', 'Humans', 'Male', 'Metabolic Syndrome', 'Mutation', 'Point Mutation', 'Polymorphism, Genetic', 'Puberty, Precocious', 'Receptor, Angiotensin, Type 2', 'Statistics, Nonparametric'] | 17,160,213 | [['G08.686.760.204', 'G08.686.841.374.204'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['G05.330'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.96... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Time-dependent amplified pharmacokinetic and pharmacodynamic responses of rabeprazole in cytochrome P450 2C19 poor metabolizers. | STUDY OBJECTIVES: To determine the pharmacokinetic and pharmacodynamic rationale for the optimum regimen of rabeprazole in the treatment of Helicobacter pylori infection in patients who are cytochrome P450 (CYP) 2C19 poor metabolizers or extensive metabolizers.DESIGN: Prospective, multiple-dose pharmacokinetic and phar... | ['2-Pyridinylmethylsulfinylbenzimidazoles', 'Academic Medical Centers', 'Adult', 'Aryl Hydrocarbon Hydroxylases', 'Benzimidazoles', 'Breath Tests', 'Cytochrome P-450 CYP2C19', 'Female', 'Gastrins', 'Genotype', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Inactivation, Metabolic', 'Male', 'Mixed Function... | 12,820,812 | [['D02.886.640.074', 'D03.383.725.024', 'D03.633.100.103.034'], ['N02.278.020'], ['M01.060.116'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['D03.633.100.103'], ['E01.370.100'], ['D08.244.453.491.500.700', 'D08.811.682.690.708.170.450.500.700', 'D12.776.422.220.453.491.500.700'], ['... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Tracking and visualization of space-time activities for a micro-scale flu transmission study. | BACKGROUND: Infectious diseases pose increasing threats to public health with increasing population density and more and more sophisticated social networks. While efforts continue in studying the large scale dissemination of contagious diseases, individual-based activity and behaviour study benefits not only disease tr... | ['Geographic Information Systems', 'Humans', 'Influenza, Human', 'Pilot Projects', 'Spatial Behavior', 'Students', 'Universities'] | 23,388,060 | [['L01.313.500.750.300.314', 'L01.470.750.750.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.310'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['F01.145.875'], ['M01.848'], ['I02.783.830', 'J03.832.830']] | ['Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
Effect of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on the phosphorylation of soluble acidic proteins in A431 epidermoid carcinoma cells. | Treatment of [32P]phosphate prelabeled intact human A431 epidermoid carcinoma cells with epidermal growth factor (EGF, 100 ng/ml) or 12-O-tetradecanoylphorbol-13-acetate (TPA, 10(-7)M) resulted in a selective enhancement in the phosphorylation of the following soluble acidic proteins: a phosphoprotein with a molecular ... | ['Bucladesine', 'Carcinoma, Squamous Cell', 'Cells, Cultured', 'Cytosol', 'Epidermal Growth Factor', 'Humans', 'Molecular Weight', 'Phorbols', 'Phosphoproteins', 'Phosphorylation', 'Protein Kinase C', 'Protein Kinases', 'Proteins', 'Tetradecanoylphorbol Acetate'] | 3,015,383 | [['D03.633.100.759.646.138.395.250', 'D13.695.462.200.250', 'D13.695.667.138.395.250', 'D13.695.827.068.395.250'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.52... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The expression of regulated endocrine-specific protein of 18 kDa in peptidergic cells of rat peripheral endocrine tissues and in blood. | We examined the cellular localization of regulated endocrine-specific protein of 18 kDa (RESP18) and mRNA in peripheral endocrine tissues. In situ hybridization and immunocytochemistry identified RESP18 mRNA in most cells of the anterior and intermediate pituitary, with RESP18 protein apparent in many anterior pituitar... | ['Adrenal Glands', 'Animals', 'Blotting, Northern', 'Blotting, Western', 'Female', 'Immunohistochemistry', 'In Situ Hybridization', 'Male', 'Nerve Tissue Proteins', 'Neuropeptide Y', 'Pancreas', 'Pituitary Gland, Anterior', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Thyroid Gland'] | 9,415,067 | [['A06.300.071'], ['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Positive Airway Pressure Therapy Is Challenging for Patients With Epilepsy. | STUDY OBJECTIVES: To investigate whether patients with epilepsy and comorbid obstructive sleep apnea (OSA) are more likely to be nonadherent to positive airway pressure (PAP) therapy than adults with OSA but without epilepsy.METHODS: This retrospective study included patients with epilepsy diagnosed with OSA and age-, ... | ['Boston', 'Comorbidity', 'Continuous Positive Airway Pressure', 'Epilepsy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Compliance', 'Polysomnography', 'Retrospective Studies', 'Sleep Apnea, Obstructive', 'Treatment Outcome'] | 29,991,426 | [['Z01.107.567.875.550.510.210', 'Z01.433.210'], ['N05.715.350.225', 'N06.850.490.687'], ['E02.041.625.790.259', 'E02.880.820.790.259'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.600'], ['E01.370... | ['Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Left heart structures in human neonates with congenital diaphragmatic hernia and the effect of fetal endoscopic tracheal occlusion. | BACKGROUND: Small left heart structures are observed in fetuses with left-sided congenital diaphragmatic hernia (CDH). Fetoscopic tracheal occlusion (FETO) in mid-gestation promotes lung growth in fetuses with CDH, however cardiac effects of FETO are poorly described. We studied the effects of FETO on cardiac structure... | ['Case-Control Studies', 'Echocardiography', 'Female', 'Fetal Development', 'Fetoscopy', 'Head', 'Heart', 'Hernia, Diaphragmatic', 'Hernias, Diaphragmatic, Congenital', 'Humans', 'Lung', 'Male', 'Regional Blood Flow', 'Retrospective Studies', 'Treatment Outcome', 'Ultrasonography, Prenatal'] | 24,356,206 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['E01.370.378.630.300', 'E01.370.388.250.280', 'E02.467.750', 'E04.502.250.280', 'E04.520.280'], ['A01.456'], ['A07.541']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cloning and characterization of a cDNA encoding topoisomerase II in pea and analysis of its expression in relation to cell proliferation. | We have isolated and sequenced four overlapping cDNA clones to identify the full-length cDNA for topoisomerase II (PsTopII) from pea. Using degenerate primers, based on the conserved amino acid sequences of other eukaryotic type II topoisomerases, a 680 bp fragment was PCR-amplified with pea cDNA as template. This frag... | ["3' Untranslated Regions", 'Amino Acid Sequence', 'Arabidopsis', 'Base Sequence', 'Blotting, Northern', 'Cell Division', 'Cloning, Molecular', 'DNA Primers', 'DNA Topoisomerases, Type II', 'DNA, Complementary', 'DNA, Plant', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Plant', 'Molecular Seq... | 10,561,074 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.650.940.800.575.912.250.157.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The effectiveness of double hulls in reducing vessel-accident oil spillage. | While much work has been done in investigating determinants of oil spillage attributed to vessel accidents, little research has been conducted on the effectiveness of ship hull design in reducing marine pollution. This paper addresses whether the double-hull requirement reduces vessel-accident oil spillage. The volume ... | ['Accident Prevention', 'Models, Theoretical', 'Petroleum Pollution', 'Regression Analysis', 'Ships', 'United States'] | 21,924,747 | [['N06.850.135.060'], ['E05.599'], ['N06.850.460.660'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['J01.937.817'], ['Z01.107.567.875']] | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
The structure of the nuclear factor-kappaB protein-DNA complex varies with DNA-binding site sequence. | Transcriptional regulation of many immune responsive genes is under the control of the transcription factor NF-kappaB. This factor is found in cells as a dimer which can contain any two members of the Rel family of proteins (p50, p65, p52, c-Rel, and RelB). The different dimers show distinct preferences for DNA-binding... | ['Binding Sites', 'Binding, Competitive', 'DNA', 'Dimerization', 'Energy Transfer', 'Fluorescence Polarization', 'Humans', 'Immunoglobulin kappa-Chains', 'Interferon-beta', 'Models, Chemical', 'NF-kappa B', 'NF-kappa B p50 Subunit', 'Nucleic Acid Conformation', 'Nucleoproteins', 'Oligodeoxyribonucleotides', 'Protein Bi... | 10,713,070 | [['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D13.444.308'], ['G02.206', 'G03.230'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['E05.196.712.516.600.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.705.750.530', 'D12.776.124.790.651.705.750.530', 'D12.776.3... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bayesian methods for FMRI time-series analysis using a nonstationary model for the noise. | In this paper, the Bayesian framework is used for the analysis of functional MRI (fMRI) data. Two algorithms are proposed to deal with the nonstationarity of the noise. The first algorithm is based on the temporal analysis of the data, while the second algorithm is based on the spatiotemporal analysis. Both algorithms ... | ['Algorithms', 'Bayes Theorem', 'Brain', 'Computer Simulation', 'Humans', 'Least-Squares Analysis', 'Linear Models', 'Magnetic Resonance Imaging', 'Monte Carlo Method', 'Motion', 'ROC Curve', 'Signal Processing, Computer-Assisted'] | 20,123,577 | [['G17.035', 'L01.224.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['A08.186.211'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Corneal Cross-Linking With Verteporfin and Nonthermal Laser Therapy. | PURPOSE: To test whether verteporfin with a nonthermal laser increases corneal mechanical stiffness and resistance to enzymatic degradation ex vivo.METHODS: Thirty human corneas (n = 5 per group) were treated with verteporfin alone (V), irradiated with nonthermal laser therapy (689 nm) alone (NTL), or received combined... | ['Biomechanical Phenomena', 'Collagen', 'Cornea', 'Cross-Linking Reagents', 'Humans', 'Low-Level Light Therapy', 'Photochemotherapy', 'Photosensitizing Agents', 'Porphyrins', 'Tensile Strength', 'Verteporfin'] | 29,176,450 | [['G01.154.090', 'G01.374.089'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A09.371.060.217'], ['D27.720.470.410.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594.540', 'E02.774.500'], ['E02.186.500', 'E02.319.685', 'E02.774.722'], ['D27.505.954.444.600', 'D27.505.954.600.710'], ['D03.383.129.578.840... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Multicenter study of the effectiveness and tolerability of desloratadine in seasonal allergic rhinitis]. | INTRODUCTION: The authors appraised the clinical efficacy of desloratadine in patients with seasonal allergic rhinitis and rhinoconjunctivitis.PATIENTS AND METHODS: An open, two-week trial was conducted on 428 patients between 3 June and 31 July 2002 in 11 centres. Nasal obstruction, rhinorrhea, sneezing, and itching a... | ['Adult', 'Female', 'Histamine H1 Antagonists, Non-Sedating', 'Humans', 'Loratadine', 'Male', 'Middle Aged', 'Rhinitis, Allergic, Seasonal', 'Treatment Outcome'] | 12,847,854 | [['M01.060.116'], ['D27.505.519.625.375.425.400.500', 'D27.505.696.577.375.425.400.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.426.559.847.181.384.340.500', 'D03.383.621.160.500', 'D04.615.181.384.340.500'], ['M01.060.116.630'], ['C08.460.799.315.750', 'C08.674.453.750', 'C09.603.799.315.750', 'C2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysis of retinol concentrations in bovine liver and its habitual consumption by pregnant women. | AIMS: The objectives of this study were to analyze retinol concentrations in two groups of bovine liver, to estimate the habitual consumption of bovine liver among pregnant women, and, based on these data, to evaluate the women's ingestion of vitamin A.METHOD: 60 samples of bovine liver, 30 of the Nelore breed and 30 o... | ['Adult', 'Animals', 'Cattle', 'Chromatography, High Pressure Liquid', 'Feeding Behavior', 'Female', 'Humans', 'Liver', 'Meat', 'Pregnancy', 'Prenatal Nutritional Physiological Phenomena', 'Vitamin A', 'Vitamins'] | 16,809,900 | [['M01.060.116'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.181.400.300'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['G07.203.300.600', 'J02.500.600'], ['G08.686.784.769'], ['G07.203.650.566.624', 'G08.686.784.769.600'], [... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Evidence of a strong association between frequency of self-monitoring of blood glucose and hemoglobin A1c levels in T1D exchange clinic registry participants. | OBJECTIVE: Despite substantial evidence of the benefit of frequent self-monitoring of blood glucose (SMBG) in type 1 diabetes, certain insurers limit the number of test strips that they will provide. The large database of the T1D Exchange clinic registry provided an opportunity to evaluate the relationship between the ... | ['Adolescent', 'Adult', 'Aged', 'Blood Glucose', 'Blood Glucose Self-Monitoring', 'Child', 'Child, Preschool', 'Diabetes Mellitus, Type 1', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Infant', 'Insulin Infusion Systems', 'Male', 'Middle Aged', 'Young Adult'] | 23,378,621 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D09.947.875.359.448.500'], ['E01.370.225.124.100.105', 'E01.370.374.100', 'E01.370.520.100', 'E02.900.950.500', 'E05.200.124.100.105'], ['M01.060.406'], ['M01.060.406.448'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['D09.400.430.937', 'D12.776.124.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Mixed amanita phalloides poisoning with rhabdomyolysis: analysis of 4 cases]. | We report the clinical characteristics, treatments and outcomes of 4 rare cases of mixed amanita fuliginea and amanita rimosa poisoning with rhabdomyolysis, and review the research progress in the intoxication mechanism and treatment. The latent time of amanita poisoning, defined as the period from the ingestion of poi... | ['Amanita', 'Hemofiltration', 'Hemoperfusion', 'Humans', 'Multiple Organ Failure', 'Mushroom Poisoning', 'Rhabdomyolysis', 'Time Factors', 'Treatment Outcome'] | 29,891,465 | [['B01.300.179.100.110'], ['E02.870.225', 'E04.292.471'], ['E02.870.244', 'E02.912.430', 'E04.292.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.835.525'], ['C25.723.415.551', 'C25.723.680.551'], ['C05.651.807'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus. | BACKGROUND: Nephropathy associated with antiphospholipid antibodies (aPL) has been proposed as a risk factor of worse renal prognosis in patients with systemic lupus erythematosus (SLE). The purpose of the current study was to evaluate the prevalence of aPL-associated nephropathy (aPLN) among patients with lupus nephri... | ['Adolescent', 'Adult', 'Aged', 'Antibodies, Anticardiolipin', 'Antibodies, Antiphospholipid', 'Biopsy', 'Creatinine', 'Female', 'Follow-Up Studies', 'Humans', 'Lupus Coagulation Inhibitor', 'Lupus Erythematosus, Systemic', 'Lupus Nephritis', 'Male', 'Middle Aged', 'Prevalence', 'Prognosis', 'Remission Induction', 'Ret... | 21,486,929 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323.210.100', 'D12.776.124.790.651.114.323.210.100', 'D12.776.377.715.548.114.323.210.100'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['E01.370.225.500.384.100', 'E01.370.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind study. | BACKGROUND: We aimed to assess efficacy and tolerability of vorinostat in combination with bortezomib for treatment of patients with relapsed or refractory multiple myeloma.METHODS: In our randomised, double-blind, placebo-controlled, phase 3 trial, we enrolled adults (?18 years) at 174 university hospitals in 31 count... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Boronic Acids', 'Bortezomib', 'Double-Blind Method', 'Drug Resistance, Neoplasm', 'Female', 'Follow-Up Studies', 'Humans', 'Hydroxamic Acids', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Neoplasm Recurrence, Local', 'Neoplasm Stag... | 24,055,414 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.029.260.110', 'D01.132.285', 'D02.203.200'], ['D01.029.260.110.500', 'D01.132.285.500', 'D02.203.200.500', 'D03.383.679.450'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cutaneous manifestations and histological features of microscopic polyangiitis. | Purpura and livedo are common cutaneous manifestations of microscopic polyangiitis (MPA); however, only a few clinical analyses focusing on the relationship between clinical symptoms and the affected vessels in the skin have been reported. We herein report the cutaneous manifestations and histological features of four ... | ['Aged', 'Diagnosis, Differential', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Skin Diseases, Vascular', 'Vasculitis'] | 19,059,827 | [['M01.060.116.100'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['C17.800.862'], ['C14.907.940']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Eradication of the chytrid fungus Batrachochytrium dendrobatidis in the Japanese giant salamander Andrias japonicus. | The purpose of this study was to establish a method for eradicating a chytrid fungus (Batrachochytrium dendrobatidis; Bd) from the Japanese giant salamander Andrias japonicus. The emerging agent (Bd) has a high rate of detection in this endangered amphibian species, which is designated as a special natural monument in ... | ['Animals', 'Antifungal Agents', 'Chytridiomycota', 'Itraconazole', 'Japan', 'Mycoses', 'Urodela'] | 22,535,874 | [['B01.050'], ['D27.505.954.122.136'], ['B01.300.283'], ['D03.383.129.799.550', 'D03.383.606.530'], ['Z01.252.474.463', 'Z01.639.595'], ['C01.150.703'], ['B01.050.150.900.090.608']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Deviance partitioning of host factors affecting parasitization in the European brown hare (Lepus europaeus). | Deviance partitioning can provide new insights into the ecology of host-parasite interactions. We studied the host-related factors influencing parasite prevalence, abundance, and species richness in European brown hares (Lepus europaeus) from northern Spain. We defined three groups of explanatory variables: host enviro... | ['Animals', 'Ecosystem', 'Environment', 'Europe', 'Female', 'Geography', 'Hares', 'Host-Parasite Interactions', 'Life Cycle Stages', 'Male', 'Models, Biological', 'Parasites', 'Population Density', 'Seasons', 'Spain'] | 19,565,211 | [['B01.050'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275', 'N06.230'], ['Z01.542'], ['H01.277.500'], ['B01.050.150.900.649.313.968.400'], ['G16.527.200.400'], ['B05.500', 'G07.345.500.550.500'], ['E05.599.395'], ['B01.050.500.714'], ['N01.224.600', 'N06.850.505.400.600'], ['G01.910.645.661', 'G16.500.275.071.590... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. | We have previously shown that most sites bound by E2F family members in vivo do not contain E2F consensus motifs. However, differences between in vivo target sites that contain or lack a consensus E2F motif have not been explored. To understand how E2F binding specificity is achieved in vivo, we have addressed how E2F ... | ['3T3 Cells', 'Animals', 'Base Sequence', 'Binding Sites', 'Cell Line', 'Chromatin Immunoprecipitation', 'Consensus Sequence', 'DNA', 'E2F Transcription Factors', 'E2F1 Transcription Factor', 'E2F4 Transcription Factor', 'HeLa Cells', 'Humans', 'Mice', 'Models, Biological', 'Oligonucleotide Array Sequence Analysis', 'P... | 18,836,037 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['A11.251.210'], ['E05.393.170', 'E05.478.605.160'], ['G02.111.570.580.175'], ['D13.444.308'], ['D12.776.930.211'], ['D12.644.360.024.328.049', 'D12.776.157.057.158.049', 'D12.776.476.02... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. | BACKGROUND: The unique phenotypic and genetic aspects of obsessive-compulsive (OCD) and attention-deficit/hyperactivity disorder (ADHD) among individuals with Tourette syndrome (TS) are not well characterized. Here, we examine symptom patterns and heritability of OCD and ADHD in TS families.METHOD: OCD and ADHD symptom... | ['Attention Deficit Disorder with Hyperactivity', 'Family', 'Humans', 'Obsessive-Compulsive Disorder', 'Phenotype', 'Tourette Syndrome'] | 28,651,666 | [['F03.625.094.150'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.080.600'], ['G05.695'], ['C10.228.140.079.898', 'C10.228.662.825.800', 'C10.574.500.850', 'C16.320.400.820', 'F03.625.992.850']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Relationship between metabolic syndrome (MS) and coronary heart disease (CHD) in an aged group. | Our study aimed at investigating the relationship between metabolic syndrome (MS) and coronary heart disease (CHD) in aged patients, including 125 patients (age> or =60 years). Of them 78 cases belonged to the CHD group, which were subdivided into the CHD-MS group (38 cases) and the simple CHD group (40 cases); the oth... | ['Aged', 'Aged, 80 and over', 'Body Mass Index', 'Cohort Studies', 'Coronary Angiography', 'Coronary Artery Disease', 'Coronary Disease', 'Female', 'Humans', 'Hyperglycemia', 'Hypertension', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Statistics as Topic', 'Triglycerides'] | 17,482,687 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I. | Synaptotagmin-I (syt-I) is required for rapid neurotransmitter release in mouse hippocampal neurons. However, contradictory results have been reported regarding evoked and spontaneous secretion from syt-I knock-out (KO) neurons. Here, we compared synaptic transmission in two different hippocampal neuron preparations: a... | ['6-Cyano-7-nitroquinoxaline-2,3-dione', 'Animals', 'Cells, Cultured', 'Electron Microscope Tomography', 'Excitatory Amino Acid Antagonists', 'Excitatory Postsynaptic Potentials', 'Glutamic Acid', 'Hippocampus', 'Immunohistochemistry', 'Mice', 'Mice, Knockout', 'Microscopy, Electron', 'Neurons', 'Patch-Clamp Techniques... | 19,515,907 | [['D03.633.100.857.160'], ['B01.050'], ['A11.251'], ['E01.370.350.825.249', 'E05.595.402.580.239'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Method for distinguishing specific from nonspecific protein-ligand complexes in nanoelectrospray ionization mass spectrometry. | A new methodology for distinguishing between specific and nonspecific protein-ligand complexes in nanoelectrospray ionization mass spectrometry (nanoES-MS) is described. The method involves the addition of an appropriate reference protein (P(ref)), which does not bind specifically to any of the solution components, to ... | ['Binding Sites', 'Carbohydrate Conformation', 'Carbohydrate Sequence', 'Carbohydrates', 'Ligands', 'Molecular Sequence Data', 'Nanotechnology', 'Proteins', 'Sensitivity and Specificity', 'Spectrometry, Mass, Electrospray Ionization'] | 16,642,987 | [['G02.111.570.120'], ['G02.111.570.820.235'], ['G02.111.570.160', 'L01.453.245.667.160'], ['D09'], ['D27.720.470.480'], ['L01.453.245.667'], ['H01.603', 'J01.897.520.600'], ['D12.776'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.8... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Phage adsorption and lytic propagation in Lactobacillus plantarum: could host cell starvation affect them? | BACKGROUND: Bacteriophages constitute a great threat to the activity of lactic acid bacteria used in industrial processes. Several factors can influence the infection cycle of bacteriophages. That is the case of the physiological state of host cells, which could produce inhibition or delay of the phage infection proces... | ['Adsorption', 'Bacillus Phages', 'Carbon', 'Culture Media', 'Kinetics', 'Lactobacillus plantarum', 'Nitrogen'] | 26,627,203 | [['G01.030', 'G02.020'], ['B04.123.100'], ['D01.268.150'], ['D27.720.470.305', 'E07.206'], ['G01.374.661', 'G02.111.490'], ['B03.353.750.450.475.612', 'B03.510.460.400.410.475.475.612', 'B03.510.550.450.475.612'], ['D01.268.604', 'D01.362.625']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serum levels of steroid and placental protein hormones in ectopic pregnancy. | UNLABELLED: The hormonal profiles of extra-uterine pregnancies (EP) were compared with the normal intra-uterine pregnancies (IUP), and threatened abortions (TA) of good outcome. In 45 cases of EP confirmed histologically, maternal serum human chorionic gonadotropin (hCG), pregnancy specific beta 1-glycoprotein (SP1), 1... | ['Abortion, Threatened', 'Chorionic Gonadotropin', 'Estradiol', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Proteins', 'Pregnancy, Ectopic', 'Pregnancy-Specific beta 1-Glycoproteins', 'Progesterone', 'Steroids'] | 2,050,251 | [['C13.703.090'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['D12.776.780'], ['C13.703.733'], ['D12.776.780.730'], ['D04.210.500.745.745.654.829',... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regular exercise limits alcohol effects on trabecular, cortical thickness and porosity, and osteocyte apoptosis in the rat. | INTRODUCTION: Excessive alcohol consumption is known to be a cause of secondary osteoporosis whereas physical activity is recommended in prevention of osteoporosis. This study was designed to analyze the effects of physical exercise on bone parameters in chronic alcohol-fed rats.METHODS: Forty-eight male Wistar rats we... | ['Alcoholic Beverages', 'Animals', 'Apoptosis', 'Bone Density', 'Disease Models, Animal', 'Ethanol', 'Femur', 'Male', 'Motor Activity', 'Osteocytes', 'Rats', 'Rats, Wistar'] | 23,380,443 | [['G07.203.100.100', 'J02.200.100'], ['B01.050'], ['G04.146.954.035'], ['G11.427.100'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.033.375'], ['A02.835.232.043.150'], ['F01.145.632', 'G11.427.410.698'], ['A11.329.629.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Occupational impairment and disability among applicants for Social Security disability benefits in Pennsylvania. | OBJECTIVE: The study goal was to assess the extent of workplace-related disease and injury among Social Security Disability Insurance applicants.METHODS: A convenience sample of 240 consecutive applicants to the Pennsylvania Bureau of Disability Determination was studied to assess the prevalence of work-related disorde... | ['Accidents, Occupational', 'Disability Evaluation', 'Disabled Persons', 'Humans', 'Insurance Claim Review', 'Occupational Diseases', 'Occupations', 'Pennsylvania', 'Population Surveillance', 'Prevalence', 'Sampling Studies', 'Social Security', 'Wounds and Injuries'] | 7,977,918 | [['N06.850.135.240'], ['E01.370.400'], ['M01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.215'], ['C24'], ['N01.824.547'], ['Z01.107.567.875.075.550', 'Z01.107.567.875.350.550', 'Z01.107.567.875.500.550'], ['E05.318.308.980.438.700', 'N05.715.360.300.800.438.625', 'N06.850.520.308.980.438.7... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Antibiotic Resistance Patterns and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus | The escalating burden of infections attributable to methicillin-resistant Staphylococcus aureus (MRSA) in East African countries is calling for interventional strategies to control the spread of this strain. The present study aimed at determining the prevalence, antimicrobial profiles, and staphylococcal cassette chrom... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Anti-Bacterial Agents', 'Bacterial Proteins', 'Child', 'Child, Preschool', 'Cross-Sectional Studies', 'Drug Resistance, Multiple, Bacterial', 'Female', 'Genotype', 'Humans', 'Infant', 'Male', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivity Tests', 'M... | 30,203,738 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['D12.776.097'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.8... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effects of dietary fish protein, soybean protein and casein on cholesterol turnover in rats. | The effects of dietary fish, soybean protein and casein on cholesterol turnover were compared in rats. After the injection of [14C]cholesterol into the rats, the specific activities of radioactive cholesterol in feces were followed for 4 weeks. The cholesterol half-lives calculated from the decay curves of the specific... | ['Animals', 'Caseins', 'Cholesterol', 'Diet', 'Dietary Proteins', 'Feces', 'Fish Products', 'Lipid Metabolism', 'Liver', 'Male', 'Nitrogen', 'Plant Proteins, Dietary', 'Plasma', 'Rats', 'Rats, Inbred Strains', 'Soybean Proteins', 'Trypsin Inhibitors'] | 4,067,670 | [['B01.050'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G07.203.650.240'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['A12.459'], ['G07.203.300.600.875.400', 'J02.500.600.875.400'], ['G03.458'], ['A03.620'], ['D01.268.604', 'D01... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Serotypes of pneumococci in pneumonia, meningitis and other pneumococcal infections. | During a five-year period, 1965 to 1969 inclusive, pneumococci from 294 patients with acute pneumococcal infections were serotyped. Pneumococci of 33 serotypes were encountered, of which types 3 and 19 were most frequent. The spectrum of infections included pneumonia, meningitis, peritonitis, otitis media and mastoidit... | ['Acute Disease', 'Adult', 'Australia', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Meningitis, Pneumococcal', 'Middle Aged', 'Pneumococcal Infections', 'Pneumonia, Pneumococcal', 'Serotyping', 'Streptococcus pneumoniae'] | 20,874 | [['C23.550.291.125'], ['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.150.252.223.500.875', 'C01.150.252.410.890.670.595', 'C01.207.180.500.875', 'C10.228.228.180.500.875', 'C10.228.614.280.560'], ['M01.06... | ['Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Association between sleep and overweight/obesity among women of childbearing age in Canada. | OBJECTIVES: Tests of the relationship between sleep and overweight/obesity (OW/OB) among women have been inconsistent. Few studies reporting such associations have focused on women of childbearing age. This paper investigates this association among Canadian women of childbearing age.METHODS: Data were from the Canadian... | ['Adolescent', 'Adult', 'Canada', 'Female', 'Health Surveys', 'Humans', 'Obesity', 'Overweight', 'Pregnancy', 'Risk Factors', 'Self Report', 'Sleep', 'Time Factors', 'Young Adult'] | 29,981,080 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.567.176'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['C23.888.144.699', 'E... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases. | Zika virus (ZIKV) has caused substantial concern worldwide owing to its association with severe birth defects, such as microcephaly and other congenital malformations. Inflammasomes, i.e., multi-protein complexes that induce inflammation and pyroptosis, are predicted to contribute to the immune response to this flavivi... | ['Brain', 'Central Nervous System', 'Cytokines', 'Female', 'Fetus', 'Humans', 'Infant, Newborn', 'Inflammasomes', 'Male', 'Microcephaly', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Zika Virus', 'Zika Virus Infection'] | 30,199,767 | [['A08.186.211'], ['A08.186'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['D05.500.224'], ['C05.660.207.620', 'C10.500.507.400.500', 'C16.131.621.207.620', 'C16.131.666.507.400.500'], ['G08.686.784.769'], ['C01.674', 'C13.70... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Short course adjuvant terlipressin in acute variceal bleeding: a randomized double blind dummy controlled trial. | BACKGROUND & AIMS: Terlipressin is recommended for 3-5 days as adjuvant to endoscopic variceal band ligation (EVBL) in esophageal variceal bleeding (EVB). We assessed whether terlipressin can be administered for a shorter period of time to patients with EVB.METHODS: All eligible EVB patients received 24h of open label ... | ['Adult', 'Chemotherapy, Adjuvant', 'Combined Modality Therapy', 'Double-Blind Method', 'Endoscopy, Digestive System', 'Esophageal and Gastric Varices', 'Female', 'Hemorrhage', 'Humans', 'Ligation', 'Lypressin', 'Male', 'Middle Aged', 'Terlipressin', 'Treatment Outcome', 'Vasoconstrictor Agents'] | 22,178,268 | [['M01.060.116'], ['E02.186.170', 'E02.319.170'], ['E02.186'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E01.370.372.250', 'E01.370.388.250.250', 'E04.210.240', 'E04.502.250.250'], ['C06.405.117.240', 'C06.552.494.414'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.11... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Location and properties of dorsal horn neurons at origin of spinoreticular tract in lumbar enlargement of the rat. | 1. Spinoreticular tract neurons at the rat lumbar cord level were identified by antidromic activation following stimulation at mainly pontine and mesencephalic levels. These units, which were found in the dorsal half of the cord, could be separated into two groups according to their spinal location, electrophysiologica... | ['Afferent Pathways', 'Animals', 'Brain Mapping', 'Brain Stem', 'Electrophysiology', 'Evoked Potentials', 'Male', 'Rats', 'Reaction Time', 'Reticular Formation', 'Spinal Cord'] | 7,441,321 | [['A08.612.220'], ['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.132'], ['H01.158.344.528', 'H01.158.782.236'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['A08.... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanistic analysis of wheat chlorophyllase. | Chlorophyllase catalyzes the initial step in the degradation of chlorophyll and plays a key role in leaf senescence and fruit ripening. Here, we report the cloning of chlorophyllase from Triticum aestivum (wheat) and provide a detailed mechanistic analysis of the enzyme. Purification of recombinant chlorophyllase from ... | ['Amino Acid Sequence', 'Biochemistry', 'Carboxylic Ester Hydrolases', 'Catalysis', 'Chlorophyll', 'Cloning, Molecular', 'Electrophoresis, Polyacrylamide Gel', 'Escherichia coli', 'Hydrogen-Ion Concentration', 'Hydrolases', 'Kinetics', 'Models, Chemical', 'Molecular Sequence Data', 'Protons', 'Sequence Homology, Amino ... | 15,913,540 | [['G02.111.570.060', 'L01.453.245.667.060'], ['H01.158.201', 'H01.181.122'], ['D08.811.277.352.100'], ['G02.130'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['E05.393.220'], ['E05.196.401.402', 'E05.301.300.319'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.300'], ['D08.81... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Severe meconium aspiration syndrome: case report. | This is a case report on severe meconium aspiration syndrome (MAS) that resulted in early neonatal death. Antenatal care was provided at a low-cost non-governmental organization (NGO) clinic. First stage of labour lasted for only 2 hours and 45 minutes. There were no foetal heart rate abnormalities that were noted duri... | ['Amniotic Fluid', 'Fatal Outcome', 'Humans', 'Infant, Newborn', 'Intensive Care, Neonatal', 'Male', 'Meconium Aspiration Syndrome'] | 17,153,662 | [['A12.098', 'A16.378.149'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E02.760.190.405', 'N02.421.585.190.500'], ['C08.381.520.687', 'C08.618.580', 'C13.703.277.785', 'C16.300.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Glibenclamide oral suspension: Suitable and effective in patients with neonatal diabetes. | BACKGROUND: Results of genetic have led to off-label glibenclamide treatment in patients with neonatal diabetes (NDM) because of potassium channel mutations. No pediatric form of glibenclamide was available. Glibenclamide was designated an orphan drug designation for NDM and a suspension was developed. As a part of the... | ['Administration, Oral', 'Adolescent', 'Blood Glucose', 'Child', 'Child, Preschool', 'Diabetes Mellitus', 'Female', 'Glyburide', 'Humans', 'Hypoglycemic Agents', 'Infant', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Male', 'Patient Acceptance of Health Care', 'Suspensions', 'Tablets', 'Treatment Outcome'] | 30,684,309 | [['E02.319.267.100'], ['M01.060.057'], ['D09.947.875.359.448.500'], ['M01.060.406'], ['M01.060.406.448'], ['C18.452.394.750', 'C19.246'], ['D02.065.950.828.575', 'D02.886.590.795.575'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['M01.060.703'], ['M01.060.703.520'], ['C16.614'], ['F01.100.150... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Arrest of the cell cycle reduces susceptibility of target cells to perforin-mediated lysis. | Cytotoxic T lymphocytes secrete a pore-forming cytolysin, perforin, that damages membranes of target cells. They also ligate Fas receptors on target cells and provoke apoptotic death. A20 (B lymphoma) and P815 (mastocytoma) cell lines were examined for their susceptibility to perforin-mediated lysis and to Fas-induced ... | ['Animals', 'Aphidicolin', 'Apoptosis', 'Cell Cycle', 'Cell Death', 'Cell Line', 'Cytoplasmic Granules', 'Cytotoxicity, Immunologic', 'Lymphoma, B-Cell', 'Mast-Cell Sarcoma', 'Membrane Glycoproteins', 'Mice', 'Perforin', 'Pore Forming Cytotoxic Proteins', 'T-Lymphocytes, Cytotoxic', 'Thymidine', 'Tumor Cells, Cultured'... | 9,620,169 | [['B01.050'], ['D02.455.849.291.075'], ['G04.146.954.035'], ['G04.144'], ['G04.146'], ['A11.251.210'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['G12.287'], ['C04.557.386.480.150', 'C15.604.515.569.480.150', 'C20.683.515.761.480.150'], ['C04.557.450.565.465.124'], ['D12.776.395.550', 'D12.776.543... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analytical identity of an inhibitor of sodium transport isolated from human serum and urine. | Inhibitors of sodium transport purified from serum and urine of healthy and uremic subjects show the same elution pattern on columns of a weak anion exchanger (DEAE Sephadex A-25), reverse-phase chromatography (Separon SI C 18) and gel permeation chromatography (Separon Hema 300 Glc). Moreover, their thin-layer chromat... | ['Biological Transport', 'Chromatography', 'Humans', 'Sodium', 'Uremia'] | 3,969,186 | [['G03.143'], ['E05.196.181'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['C12.777.419.936', 'C13.351.968.419.936']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Allowing for correlations between correlations in random-effects meta-analysis of correlation matrices. | Practical meta-analysis of correlation matrices generally ignores covariances (and hence correlations) between correlation estimates. The authors consider various methods for allowing for covariances, including generalized least squares, maximum marginal likelihood, and Bayesian approaches, illustrated using a 6-dimens... | ['Bayes Theorem', 'Humans', 'Meta-Analysis as Topic', 'Models, Psychological'] | 18,179,354 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.500', 'E05.581.500.501', 'N05.715.360.325.515', 'N06.850.520.445.500'], ['E05.599.695']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Optical diagnosis of cervical cancer by fluorescence spectroscopy technique. | In the present work, we examine normal and malignant stage IIIB cervical tissue by laser induced fluorescence, with 2 different objectives. (i) Development of the fluorescence spectroscopy technique as a standard optical method for discrimination of normal and malignant tissue samples and, (ii) Optimization of the tech... | ['Adult', 'Calibration', 'Female', 'Humans', 'Lasers', 'Middle Aged', 'Neoplasm Staging', 'Sensitivity and Specificity', 'Spectrometry, Fluorescence', 'Uterine Cervical Neoplasms'] | 16,450,394 | [['M01.060.116'], ['E05.978.155'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.632.490', 'E07.710.520'], ['M01.060.116.630'], ['E01.789.625'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E05.196.712.516.600.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Comparison of lung protection for hydrochloric acid or oleic acid induced rat acute respiratory distress syndrome models pretreated with penehyclidine]. | OBJECTIVE: To compare the lung protection roles of intraperitoneal pre-injection with penehyclidine for two kinds of rat models with pulmonary and extrapulmonary acute respiratory distress syndrome (ARDSp and ARDSexp).METHODS: Forty healthy adult Sprague-Dawley (SD) rats were randomly divided into five groups (each n =... | ['Animals', 'Hydrochloric Acid', 'Lung', 'Oleic Acid', 'Quinuclidines', 'Rats', 'Rats, Sprague-Dawley', 'Respiratory Distress Syndrome'] | 29,764,547 | [['B01.050'], ['D01.029.260.326', 'D01.210.450'], ['A04.411'], ['D10.251.355.325.600.525'], ['D03.605.687'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['C08.381.840', 'C08.618.840']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of prematurity on language skills at school age. | PURPOSE: The existing literature on language outcomes in children born prematurely focuses almost exclusively on standardized test scores rather than discourse-level abilities. The authors of this study looked longitudinally at school-age language outcomes and potential moderating variables for a group of twins born pr... | ['Attention', 'Child', 'Child Development', 'Child Language', 'Executive Function', 'Female', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Language Development', 'Longitudinal Studies', 'Male', 'Parents', 'Regression Analysis', 'Semantics', 'Verbal Behavior'] | 24,167,241 | [['F02.830.104.214'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['F01.525.200.310.250'], ['F02.463.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['F01.525.200.310'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Chemotactic clusters in confined run-and-tumble bacteria: a numerical investigation. | We present a simulation study of pattern formation in an ensemble of chemotactic run-and-tumble bacteria, focussing on the effect of spatial confinement, either within traps or inside a maze. These geometries are inspired by previous experiments probing pattern formation in chemotactic strains of E. coli under these co... | ['Escherichia coli', 'Particle Size', 'Surface Properties'] | 24,652,099 | [['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.712'], ['G02.860']] | ['Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Digoxigenylated wheat germ agglutinin visualized with alkaline phosphatase-labeled anti-digoxigenin antibodies--a new, sensitive technique with the potential for single and double tracing of neuronal connections. | For double tracing experiments, wheat germ agglutinin (WGA) molecules labeled with two different haptens are desirable. In the present report the suitability of digoxigenylated WGA (DIG-WGA) for retrograde tracing was investigated. For this purpose the new tracer was pressure injected into rat brains and the transporte... | ['Alkaline Phosphatase', 'Animals', 'Brain', 'Digoxigenin', 'Horseradish Peroxidase', 'Immunohistochemistry', 'Male', 'Neural Pathways', 'Neurons', 'Olfactory Bulb', 'Rats', 'Rats, Inbred Strains', 'Staining and Labeling', 'Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate', 'Wheat Germ Agglutinins'] | 1,708,475 | [['D08.811.277.352.650.035'], ['B01.050'], ['A08.186.211'], ['D04.210.500.155.580.130.688.350'], ['D08.811.682.732.512'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrocardiographic alterations during endosseous implant placement performed with local anesthetic agents. | PURPOSE: The purpose of this study was to analyze electrocardiographic alterations during dental implant surgeries when local anesthetic agents were used.MATERIALS AND METHODS: Twenty implants were placed in 18 healthy patients. An electrocardiogram and Wincardio software were used to gather recordings from 12 static l... | ['Adult', 'Age Factors', 'Anesthetics, Local', 'Arrhythmias, Cardiac', 'Dental Implantation, Endosseous', 'Electrocardiography', 'Epinephrine', 'Heart Conduction System', 'Heart Rate', 'Humans', 'Mepivacaine', 'Middle Aged', 'Stress, Psychological', 'Vasoconstrictor Agents', 'Young Adult'] | 19,587,862 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['C14.280.067', 'C23.550.073'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['E01.370.370.380.240', 'E01.370.405.240'], ['D02.033.100... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
UV damage in DNA promotes nucleosome unwrapping. | The association of DNA with histones in chromatin impedes DNA repair enzymes from accessing DNA lesions. Nucleosomes exist in a dynamic equilibrium in which portions of the DNA molecule spontaneously unwrap, transiently exposing buried DNA sites. Thus, nucleosome dynamics in certain regions of chromatin may provide the... | ['Animals', 'DNA', 'DNA Damage', 'DNA Repair', 'DNA Restriction Enzymes', 'Fluorescence Resonance Energy Transfer', 'Histones', 'Nucleosomes', 'Ultraviolet Rays', 'Xenopus laevis'] | 20,562,439 | [['B01.050'], ['D13.444.308'], ['G05.200'], ['G02.111.222', 'G05.219'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['A11.284.430.106.279.345.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Calcium-mediated coupling between mitochondrial substrate dehydrogenation and cardiac workload in single guinea-pig ventricular myocytes. | We measured mitochondrial NADH autofluorescence or Ca(2+) using Rhod-2, simultaneously with cell shortening in isolated guinea-pig ventricular myocytes. When both frequency and amplitude of twitch shortening (work intensity) were increased by raising stimulus frequency in incremental steps from 0.1 to 3.3 Hz, the stead... | ['Animals', 'Calcium', 'Computer Simulation', 'Feedback', 'Guinea Pigs', 'Heart Ventricles', 'In Vitro Techniques', 'Mitochondria, Heart', 'Myocardium', 'Myocytes, Cardiac', 'NAD', 'Patch-Clamp Techniques', 'Substrate Specificity'] | 16,480,740 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['L01.224.160'], ['L01.906.394.211'], ['B01.050.150.900.649.313.992.550'], ['A07.541.560'], ['E05.481'], ['A11.284.430.214.190.875.564.627.603', 'A11.284.835.626.627.603'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['A07.541.704.570', 'A10.69... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Strategies of smoking cessation intervention before hernia surgery--effect on perioperative smoking behavior. | BACKGROUND: Although it is now generally accepted that patients should be advised to quit smoking before surgery, the effect of low-intensive smoking cessation intervention, both on preoperative smoking behavior and on risk reduction, remains unclear. Our objective was to study the effect on perioperative smoking behav... | ['Adult', 'Aged', 'Female', 'Follow-Up Studies', 'Hernia, Abdominal', 'Hernia, Inguinal', 'Humans', 'Male', 'Middle Aged', 'Perioperative Care', 'Practice Guidelines as Topic', 'Retrospective Studies', 'Risk Factors', 'Smoking', 'Smoking Cessation', 'Treatment Outcome'] | 17,503,161 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.300.707.374'], ['C23.300.707.374.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.731', 'E04.604', 'N02.421.585.722'], ['N04.761.700.350.650', 'N0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expanding ART for treatment and prevention of HIV in South Africa: estimated cost and cost-effectiveness 2011-2050. | BACKGROUND: Antiretroviral Treatment (ART) significantly reduces HIV transmission. We conducted a cost-effectiveness analysis of the impact of expanded ART in South Africa.METHODS: We model a best case scenario of 90% annual HIV testing coverage in adults 15-49 years old and four ART eligibility scenarios: CD4 count <2... | ['Anti-HIV Agents', 'CD4 Lymphocyte Count', 'Cost-Benefit Analysis', 'Costs and Cost Analysis', 'Forecasting', 'HIV Infections', 'Humans', 'South Africa'] | 22,348,000 | [['D27.505.954.122.388.077.088'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['N03.219.151.125'], ['N03.219.151'], ['I01.320'], ['C01.22... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Measurements of blood citrates in neoplasms with bone metastases]. | Blood citrate was measured in 49 patients with cancer, with or without bone metastases, and in 53 normal subjects. It is significantly higher (p less than 0.001) in patients with bone metastases than in normal subjects or patients without bone metastases. In normal subjects, blood citrate is higher in summer than in wi... | ['Adult', 'Age Factors', 'Animals', 'Bone Neoplasms', 'Cats', 'Citrates', 'Humans', 'Neoplasm Metastasis', 'Seasons'] | 568,307 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['C04.588.149', 'C05.116.231'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['D02.241.081.901.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650', 'C23.550.727.650'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.10... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Regional contamination versus regional dietary differences: understanding geographic variation in brominated and chlorinated contaminant levels in polar bears. | The relative contribution of regional contamination versus dietary differences to geographic variation in polar bear (Ursus maritimus) contaminant levels is unknown. Dietary variation between Alaska, Canada, East Greenland, and Svalbard subpopulations was assessed by muscle nitrogen and carbon stable isotope (ä(15)N, ä... | ['Alaska', 'Animals', 'Bromine Compounds', 'Canada', 'Chlorine Compounds', 'Diet', 'Environmental Monitoring', 'Environmental Pollutants', 'Female', 'Flame Retardants', 'Greenland', 'Halogenated Diphenyl Ethers', 'Polychlorinated Biphenyls', 'Svalbard', 'Ursidae'] | 21,166,451 | [['Z01.107.567.875.580.100'], ['B01.050'], ['D01.139'], ['Z01.107.567.176'], ['D01.210'], ['G07.203.650.240'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['D27.720.361'], ['Z01.107.567.403', 'Z01.542.816.124.500', 'Z01.639.400'], ['D02.355.726.601', 'D02.455.426.559.389.657.654.601'], ['D02.309.750', ... | ['Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Functional inhibition of urea transporter UT-B enhances endothelial-dependent vasodilatation and lowers blood pressure via L-arginine-endothelial nitric oxide synthase-nitric oxide pathway. | Mammalian urea transporters (UTs), UT-A and UT-B, are best known for their role in urine concentration. UT-B is especially distributed in multiple extrarenal tissues with abundant expression in vascular endothelium, but little is known about its role in vascular function. The present study investigated the physiologica... | ['Animals', 'Arginine', 'Blood Pressure', 'Diuretics', 'Endothelium, Vascular', 'Gene Deletion', 'Gene Expression', 'Intracellular Space', 'Male', 'Membrane Transport Proteins', 'Mice', 'Models, Animal', 'Nitric Oxide', 'Nitric Oxide Synthase Type III', 'Rats', 'Signal Transduction', 'Vasodilation'] | 26,739,766 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.696.560.500'], ['A07.015.700.500', 'A10.272.491.355'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.297'], ['A10.082.750', 'A11.284.430'], ['D12.776.157.530', 'D12.776.543.585'], ['B01.050... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular characterization and expression analysis of a gene encoding for farnesyl diphosphate synthase from Euphorbia pekinensis Rupr. | The root of Euphorbia pekinensis as a traditional herbal medicine has been recorded in Chinese pharmacopoeias for the treatment of oedema, gonorrhea, migraine and wart cures. In this work, we reported on the cDNA cloning and characterization of a novel farnesyl diphosphate synthase (FPS) from E. pekinensis. The full-le... | ['Acetates', 'Base Sequence', 'Blotting, Southern', 'Cloning, Molecular', 'Cyclopentanes', 'DNA, Complementary', 'Euphorbia', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Genetic Complementation Test', 'Geranyltranstransferase', 'Molecular Sequence Data', 'Open Reading Frames', 'Oxylipins', 'Salic... | 21,614,522 | [['D02.241.081.018', 'D10.251.400.045'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.393.220'], ['D02.455.426.392.368.450'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.650.940.800.575.912.250.859.797.43... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Using e-cigarettes in the home to reduce smoking and secondhand smoke: disadvantaged parents' accounts. | Electronic cigarettes (e-cigarettes) are subject to considerable public health debate. Most public health experts agree that for smokers who find it particularly challenging to quit, e-cigarettes may reduce harm. E-cigarette use in the home may also reduce children's secondhand smoke (SHS) exposure, although e-cigarett... | ['Adult', 'Electronic Nicotine Delivery Systems', 'Female', 'Humans', 'Male', 'Middle Aged', 'Public Health', 'Qualitative Research', 'Scotland', 'Smoking', 'Smoking Cessation', 'Tobacco Smoke Pollution', 'Vulnerable Populations'] | 28,087,586 | [['M01.060.116'], ['J01.637.767.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['H01.770.644.241.850'], ['Z01.542.363.766'], ['F01.145.805'], ['F01.145.488.732'], ['D20.633.937.680', 'N06.850.460.100.555'], ['M01.965']] | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Isolation of rat hepatocytes. | In vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase of drug development. An important breakthrough in establishing cell models has been the successful high-yield preparation of intact hepatocytes. In this chapter, the practical aspects of the two-step collagenase perfusion... | ['Animals', 'Cell Separation', 'Collagenases', 'G1 Phase', 'Hepatocytes', 'Humans', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Resting Phase, Cell Cycle'] | 16,719,394 | [['B01.050'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['G04.144.500.320'], ['A11.436.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay. | F?rster resonance energy transfer (FRET)-based studies have become increasingly common in the investigation of GPCR signaling. Our research group developed an intra-molecular FRET sensor to detect the interaction between Gá subunits and GPCRs in live cells following agonist stimulation. Here, we detail the protocol for... | ['Biosensing Techniques', 'Fluorescence Resonance Energy Transfer', 'HEK293 Cells', 'Humans', 'Ligands', 'Protein Conformation', 'Receptors, Adrenergic, beta-2', 'Receptors, G-Protein-Coupled', 'Signal Transduction'] | 27,684,955 | [['E05.601.043'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['G02.111.570.820.709'], ['D12.776.543.750.670.300.300.340.200', 'D12.776.543.750.695.150.300.340.725', 'D12.776.543.750.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Right to health encompasses right to access essential generic medicines: challenging the 2008 Anti-Counterfeit Act in Kenya. | To what extent has the right to access generic HIV medication been implemented in Kenya for the 1.6 million people living with HIV? How does this relate to the right to health under international and national law? This paper examines a constitutional challenge brought to the High Court of Kenya in 2009 (the "Anti-Count... | ['Anti-HIV Agents', 'Counterfeit Drugs', 'Drugs, Generic', 'Health Services Accessibility', 'Humans', 'Judicial Role', 'Kenya', 'Legislation, Drug', 'Patient Rights'] | 25,569,728 | [['D27.505.954.122.388.077.088'], ['D26.894.500'], ['D26.360'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.583.474'], ['Z01.058.290.120.400'], ['I01.880.604.605', 'N03.706.615.402'], ['I01.880.604.473.650', 'N03.706.437.650']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Detection of platelet-directed immunoglobin G in sera using the peroxidase-anti-peroxidase (PAP) slide technique. | An immunohistochemical procedure for the detection of immunoglobulin G adherent to platelets is described. The peroxidase anti-peroxidase method is used to detect antibody activity directed against platelets from normal donors in the sera from 305 individuals. These subjects were divided into three groups: group 1, pat... | ['ABO Blood-Group System', 'Absorption', 'Animals', 'Blood Platelets', 'Female', 'Fluorescent Antibody Technique', 'Goats', 'HLA Antigens', 'Humans', 'Immunoenzyme Techniques', 'Immunoglobulin G', 'Male', 'Pregnancy', 'Purpura', 'Rabbits', 'Receptors, Antigen, B-Cell'] | 6,986,179 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['B01.050'], ['A11.118.188', 'A15.145.229.188'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.050.150.90... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Administration of Bifidobacterium breve PS12929 and Lactobacillus salivarius PS12934, two strains isolated from human milk, to very low and extremely low birth weight preterm infants: a pilot study. | The preterm infant gut has been described as immature and colonized by an aberrant microbiota. Therefore, the use of probiotics is an attractive practice in hospitals to try to reduce morbidity and mortality in this population. The objective of this pilot study was to elucidate if administration of two probiotic strain... | ['Bifidobacterium', 'Biodiversity', 'Cluster Analysis', 'Female', 'Gastrointestinal Microbiome', 'Humans', 'Immunity', 'Infant, Extremely Low Birth Weight', 'Infant, Newborn', 'Infant, Very Low Birth Weight', 'Lactobacillus', 'Milk, Human', 'Pilot Projects', 'Probiotics'] | 25,759,843 | [['B03.510.024.100', 'B03.510.460.400.400.049.100'], ['G16.500.275.157.049', 'N06.230.124.049'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450'], ['M01.060.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. | Loss of the of the maintenance methyltransferase xDNMT1 during Xenopus development results in premature transcription and activation of a p53-dependent apoptotic program that accounts for embryo lethality. Here, we show that activation of the apoptotic response is signalled through the methyl-CpG binding protein xMBD4 ... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Apoptosis', 'Cells, Cultured', 'DNA (Cytosine-5-)-Methyltransferase 1', 'DNA (Cytosine-5-)-Methyltransferases', 'DNA Damage', 'DNA Repair', 'DNA Repair Enzymes', 'Endodeoxyribonucleases', 'Enzyme Activation', 'Fibroblasts', 'Heterochromatin', 'Humans', 'Mice', 'Nucle... | 19,502,488 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['G04.146.954.035'], ['A11.251'], ['D08.811.913.555.500.350.100.500.500', 'D12.776.157.687.313', 'D12.776.660.720.313'], ['D08.811.913.555.500.350.100.500'], ['G05.200'], ['G02.111.222', 'G05.219'], ['D08.811.074'], ['D08.811.277.352.335.350', 'D0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prevention of suppression of alloreactive capacity following intravenous injection of neuraminidase-treated allogeneic cells by co-injection of agents competing for asialoglycoprotein receptor. | Intravenous (i.v.) administration of neuraminidase (Nase)-treated allogeneic lymphocytes resulted in the complete abrogation of the capacity to develop delayed-type hypersensitivity (DTH) responses to the relevant alloantigens (tolerance induction). The Nase treatment did not influence the antigenicity of allogeneic ly... | ['Animals', 'Asialoglycoprotein Receptor', 'Cells, Cultured', 'Erythrocyte Transfusion', 'Erythrocytes', 'Female', 'Hypersensitivity, Delayed', 'Immune Tolerance', 'Isoantigens', 'Lectins', 'Liver', 'Lymphocyte Transfusion', 'Lymphocytes', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C3H', 'Neuraminidase', 'Peanut Aggl... | 3,275,127 | [['B01.050'], ['D12.776.503.280.124', 'D12.776.543.750.024'], ['A11.251'], ['E02.095.135.140.275'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['C20.543.418'], ['G12.535.425'], ['D23.050.705'], ['D12.776.503'], ['A03.620'], ['E02.095.135.140.425.445'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of the polymorphism of prolactin receptor (PRLR) and leptin (LEP) genes on litter size in Polish pigs. | The aim of the experiment was to use the DNA mutations in the PRLR and LEP genes to determine associations between the genotype and litter size in Polish Large White x Landrace sows. Reproductive traits investigated were: total number of piglets born (TNB), number of piglets born alive (NBA) and number of piglets weane... | ['Animals', 'DNA Primers', 'Gene Frequency', 'Leptin', 'Litter Size', 'Poland', 'Polymorphism, Genetic', 'Polymorphism, Restriction Fragment Length', 'Quantitative Trait, Heritable', 'Receptors, Prolactin', 'Sus scrofa'] | 16,274,424 | [['B01.050'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.330'], ['D06.472.699.042.500', 'D12.644.276.024.500', 'D12.644.548.011.500', 'D12.776.467.024.500', 'D23.529.024.500'], ['G08.686.530', 'G08.686.784.769.498.300'], ['Z01.542.248.679'], ['G05.365.795'], ['G05.365.795.595'], ['G05.420.720'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Secondary plant substances in various extracts of the leaves, fruits, stem and bark of Caraipa densifolia Mart. | Thirty secondary plant substances were detected in various extracts of the leaves, fruits, stem and bark of Caraipadensifolia Mart. Phenolic compounds were preliminarily identified and quantitated by HPLC-ESI-MS and the structures of the compounds, purified by semi-preparative HPLC, were further characterized by nano-E... | ['Chromatography, Gas', 'Chromatography, High Pressure Liquid', 'Clusiaceae', 'Plant Bark', 'Plant Extracts', 'Plant Leaves', 'Plant Stems', 'Spectrometry, Mass, Electrospray Ionization'] | 20,347,919 | [['E05.196.181.349'], ['E05.196.181.400.300'], ['B01.650.940.800.575.912.250.859.625'], ['A18.024.750.200'], ['D20.215.784.500', 'D26.667'], ['A18.024.812'], ['A18.024.937'], ['E05.196.566.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subchronic methamphetamine treatment enhances ouabain-induced striatal dopamine efflux in vivo. | The effect of manipulation of the Na+ gradient between the intracellular and extracellular media on striatal dopamine (DA) efflux under steady-state conditions after subchronic methamphetamine (MAP) treatment was investigated. Rats were injected with 4 mg/kg MAP or saline (i.p.), once daily for 14 days. Seven days afte... | ['3,4-Dihydroxyphenylacetic Acid', 'Animals', 'Autoradiography', 'Corpus Striatum', 'Dopamine', 'Homovanillic Acid', 'Hydroxyindoleacetic Acid', 'Kinetics', 'Male', 'Methamphetamine', 'Methyltyrosines', 'Ouabain', 'Perfusion', 'Rats', 'Rats, Inbred Strains', 'Reference Values', 'Reserpine', 'Sodium-Potassium-Exchanging... | 1,371,707 | [['D02.241.223.601.220'], ['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A08.186.211.200.885.287.249.487'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D02.241.223.601.521'], ['D03.066.288.478', 'D03.633.100.473.404.478'], ['G01.374.661', 'G02.111.490'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
'I had this horrible pain': the sources and causes of pain experiences in 4- to 11-year-old hospitalized children. | Researchers have relied, almost without exception, on adults for qualitative information about children's pain. However, adults may provide only a limited view of children's pain experience. The purpose of this article is to describe the events considered painful by children. Forty-four children participated in the stu... | ['Child', 'Child, Preschool', 'Female', 'Finland', 'Humans', 'Male', 'Pain', 'Pain Measurement', 'Pediatric Nursing'] | 15,358,886 | [['M01.060.406'], ['M01.060.406.448'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['E01.370.600.550.324'], ['H02.478.676.631', 'N02.421.533.691']] | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Large geographic distance versus small DNA barcode divergence: Insights from a comparison of European to South Siberian Lepidoptera. | Spanning nearly 13,000 km, the Palearctic region provides an opportunity to examine the level of geographic coverage required for a DNA barcode reference library to be effective in identifying species with broad ranges. This study examines barcode divergences between populations of 102 species of Lepidoptera from Europ... | ['Animal Distribution', 'Animals', 'DNA', 'DNA Barcoding, Taxonomic', 'Europe', 'Genetic Variation', 'Lepidoptera', 'Siberia', 'Spatial Analysis', 'Species Specificity'] | 30,388,147 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['D13.444.308'], ['E05.393.542.249', 'E05.393.760.700.149'], ['Z01.542'], ['G05.365'], ['B01.050.500.131.617.720.500.500.937'], ['Z01.252.122.500.500'], ['E05.318.740.933', 'N05.715.360.750.746', 'N06.850.520.830.933'], ['G16.824']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Modeling the adaptive visual system: a survey of principled approaches. | Modeling the visual system can be done at multiple levels of description ranging from computer simulations of detailed biophysical models to firing rate and so-called 'black-box' models. Re-introducing David Marr's analysis levels for the visual system, we motivate the use of more abstract models in order to answer the... | ['Adaptation, Physiological', 'Models, Neurological', 'Vision, Ocular'] | 14,622,889 | [['G07.025', 'G16.012.500'], ['E05.599.395.642'], ['F02.830.816.964', 'G02.111.820.480.900', 'G04.835.480.900', 'G11.561.790.964', 'G14.935']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of plant severing on movement of Ostrinia nubilalis larvae in Zea mays hybrid seed production fields. | Genetically engineered corn hybrids that contain a cry gene from the bacterium Bacillus thuringiensis Berliner (Bt) are gaining popularity for controlling the corn pest Ostrinia nubilalis (H?bner). Continuous use of Bt corn, however, could select for O. nubilalis that are resistant to this corn. Monitoring for insect r... | ['Agriculture', 'Animal Migration', 'Animals', 'Bacillus thuringiensis', 'Bacillus thuringiensis Toxins', 'Bacterial Proteins', 'Bacterial Toxins', 'Endotoxins', 'Hemolysin Proteins', 'Hybridization, Genetic', 'Insect Control', 'Insecticide Resistance', 'Larva', 'Moths', 'Plants, Genetically Modified', 'Seeds', 'Time F... | 17,849,861 | [['J01.040'], ['F01.145.113.069.500'], ['B01.050'], ['B03.300.390.400.158.218.800', 'B03.353.500.100.218.800', 'B03.510.100.100.218.800', 'B03.510.415.400.158.218.800', 'B03.510.460.410.158.218.800'], ['D23.946.123.090'], ['D12.776.097'], ['D23.946.123'], ['D23.946.123.329'], ['D12.776.543.695.444'], ['E05.820.150.390'... | ['Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Genetic diversity and the structure of genealogies in rapidly adapting populations. | Positive selection distorts the structure of genealogies and hence alters patterns of genetic variation within a population. Most analyses of these distortions focus on the signatures of hitchhiking due to hard or soft selective sweeps at a single genetic locus. However, in linked regions of rapidly adapting genomes, m... | ['Adaptation, Biological', 'Evolution, Molecular', 'Genetic Loci', 'Genetic Variation', 'Haploidy', 'Models, Genetic', 'Models, Statistical', 'Mutation', 'Pedigree', 'Population', 'Reproduction, Asexual', 'Selection, Genetic'] | 23,222,656 | [['G16.012'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.380'], ['G05.365'], ['G05.700.456'], ['E05.599.395.397'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G05.365.590'], ['E05.393.673'], ['N01.600'], ['G08.686.784.830'], ['G05.783']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Changes of factors on disease activity in advancing periodontitis]. | Two test teeth, anteriors with greater than or equal to 6 mm deep periodontal pockets from each of 10 patients with advancing periodontitis were included in this study. The clinical signs of advancing periodontitis, generalized moderate to deep pockets and to severe loss of alveolar bone, were observed in young adult. ... | ['Adult', 'Bacteroides', 'Endotoxins', 'Female', 'Gingival Crevicular Fluid', 'Glucuronidase', 'Humans', 'Interleukin-1', 'Male', 'Periodontitis', 'Prognosis'] | 2,135,609 | [['M01.060.116'], ['B03.440.080.094.152', 'B03.440.425.410.194.152'], ['D23.946.123.329'], ['A12.383.500'], ['D08.811.277.450.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.5... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Age dependent changes in the sperm population and fertility in the male rat. | The entire reproductive tract was devoid of spermatozoa during the first 42 days of life. The first appearance of spermatozoa was detected in the caput epididymidis of 45-day old rats and in the cauda epididymidis of 52-day or older rats. The number of spermatozoa in the reproductive tract increased with age. The sperm... | ['Aging', 'Animals', 'Epididymis', 'Fertility', 'Male', 'Organ Size', 'Rats', 'Sexual Maturation', 'Sperm Count', 'Testis'] | 520,388 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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