Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Ghrelin levels in children with constitutional delay of growth and puberty. | OBJECTIVE: In this study, we aimed to show the role of ghrelin in growth delay in children with constitutional delay of growth and puberty (CDGP).METHODS: Thirty male children with CDGP constituted the study group and fifteen healthy children with normal growth of similar ages-the control group. In both groups, fasting... | ['Adolescent', 'Age Determination by Skeleton', 'Body Height', 'Body Mass Index', 'Body Weight', 'Child', 'Dietary Proteins', 'Energy Intake', 'Enzyme-Linked Immunosorbent Assay', 'Fasting', 'Ghrelin', 'Growth Disorders', 'Humans', 'Insulin-Like Growth Factor Binding Protein 3', 'Insulin-Like Growth Factor I', 'Male', ... | 21,274,325 | [['M01.060.057'], ['E01.370.049', 'E01.370.350.700.050'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys. | Peroxisome proliferator-activated receptors (PPARs) are involved in the regulation of lipid and glucose metabolism. PPARgamma agonists improve insulin sensitivity and hyperglycemia and are effective in treating type 2 diabetes mellitus (T2DM), whereas PPARalpha agonists are used to treat dyslipidemia and atherosclerosi... | ['Adiponectin', 'Animals', 'Area Under Curve', 'Blood Glucose', 'C-Reactive Protein', 'Diabetes Mellitus, Type 2', 'Dose-Response Relationship, Drug', 'Glucose Tolerance Test', 'Hypoglycemic Agents', 'Hypolipidemic Agents', 'Insulin Resistance', 'Lipids', 'Lipoproteins', 'Macaca fascicularis', 'PPAR alpha', 'Piperidine... | 20,190,014 | [['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['B01.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D09.947.875.359.448.500'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C18.452.394.750.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Clinical features and treatment outcomes of vancomycin-intermediate Staphylococcus aureus (VISA) and heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) in a tertiary care institution in Singapore. | This retrospective case-control study was undertaken to review the clinical features associated with heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections and the local impact they have on clinical outcome. Compared with vancomycin-susceptible S. a... | ['Adult', 'Aged', 'Anti-Bacterial Agents', 'Case-Control Studies', 'Female', 'Health Care Costs', 'Hospitals', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Retrospective Studies', 'Singapore', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Treatment Failure', 'Treatment Outcome', 'Vancomycin Resistance'] | 19,387,707 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N03.219.151.400', 'N05.300.375'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['E05.318.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Humoral hyporesponsiveness to a conjugate contraceptive vaccine and its bypass by diverse carriers using permissible adjuvant. | A contraceptive vaccine directed against human chorionic gonadotropin (hCG) has previously undergone clinical testing that demonstrated the feasibility of the approach in preventing pregnancy in women. Some immunized volunteers however, did not respond with an adequate anti-hCG antibody response despite employing highl... | ['Adjuvants, Immunologic', 'Amino Acid Sequence', 'Animals', 'Antibody Formation', 'Antigens, Bacterial', 'Cell Division', 'Chorionic Gonadotropin', 'Contraceptive Agents, Female', 'Diphtheria Toxoid', 'Female', 'Humans', 'Lipoproteins', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Inbred CBA', 'Molecula... | 11,012,625 | [['D27.505.696.477.067'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G12.450.050.370.250'], ['D23.050.161'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D27.505.696.875.360.276', 'D2... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Trends in blood pressure control in hypertensive patients with diabetes mellitus in Japan. | Hypertension is often accompanied by type 2 diabetes mellitus. Recently, the American Diabetes Association (ADA) published guidelines on the treatment of hypertension in adult patients with diabetes mellitus. However, the views of general physicians on how to control blood pressure (BP) in diabetic patients and the imp... | ['Adult', 'Angiotensin Receptor Antagonists', 'Angiotensin-Converting Enzyme Inhibitors', 'Antihypertensive Agents', 'Calcium Channel Blockers', 'Diabetes Mellitus, Type 2', 'Female', 'Guideline Adherence', 'Humans', 'Hypertension', 'Japan', 'Male', 'Middle Aged', 'Practice Guidelines as Topic', 'Surveys and Questionna... | 14,620,927 | [['M01.060.116'], ['D27.505.519.162'], ['D27.505.519.389.745.085'], ['D27.505.954.411.162'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['C18.452.394.750.149', 'C19.246.300'], ['N04.761.337', 'N05.715.360.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['Z01.252.474.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Two evolutionary histories in the genome of rice: the roles of domestication genes. | Genealogical patterns in different genomic regions may be different due to the joint influence of gene flow and selection. The existence of two subspecies of cultivated rice provides a unique opportunity for analyzing these effects during domestication. We chose 66 accessions from the three rice taxa (about 22 each fro... | ['Crops, Agricultural', 'Evolution, Molecular', 'Gene Flow', 'Genetic Variation', 'Genome, Plant', 'Oryza'] | 21,695,282 | [['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['G05.045.250', 'G16.075.250'], ['G05.330.159'], ['G05.365'], ['G05.360.340.365'], ['B01.650.940.800.575.912.250.822.616']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
In vitro dual perfusion of human placental lobules as a flow phantom to investigate the relationship between fetoplacental flow and quantitative 3D power doppler angiography. | Flow phantoms have been used to investigate and quantify three-dimensional power Doppler data but this is the first study to use the in vitro, dual perfused, placental perfusion model. We used this model to investigate and quantify the effect of variation in fetal-side flow rates and attenuation on 3D power Doppler ang... | ['Adult', 'Female', 'Fetus', 'Humans', 'Image Interpretation, Computer-Assisted', 'Maternal-Fetal Exchange', 'Organ Culture Techniques', 'Perfusion', 'Placental Circulation', 'Pregnancy', 'Regional Blood Flow', 'Ultrasonography, Doppler', 'Young Adult'] | 19,059,643 | [['M01.060.116'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['G08.686.784.769.455'], ['E05.481.500.484'], ['E05.680'], ['G09.330.100.749'], ['G08.686.784.769'], ['G09.330.100.780'], ['E01.370.350.850.850'], ['M01.060.116.815']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Examining the influence of perceived and objective time constraints on the quality of household food purchases. | BACKGROUND: Obesity is a major public health concern in the United States. From the late 1970s through the mid-1990s, the reduction in the amount of time individuals spent preparing food coincided with changes in the food environment. This led to increased consumption of energy and contributed to the dramatic rise in o... | ['Adult', 'Consumer Behavior', 'Family Characteristics', 'Fast Foods', 'Female', 'Food Preferences', 'Humans', 'Income', 'Male', 'Middle Aged', 'Surveys and Questionnaires', 'Time Factors', 'United States'] | 30,142,374 | [['M01.060.116'], ['F01.145.236'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['G07.203.300.477', 'J02.500.477'], ['F01.145.407.516', 'G07.203.650.353.516'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['M01.060.116.630'], ['E05.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
[Anatomical education in the late Meiji era --Lu Xun, doctor Fujino and their comtemporaries]. | Lu Xun studied medicine at Sendai Medical School for 1 and a half years and then changed his course to Literature. In his novel "Doctor Fujino", Lu Xun told his memory on the anatomical notes in which Professor Fujino made numerous corrections. I analyzed the anatomical notes by Lu Xun and his classmates, and revealed ... | ['Anatomy', 'Anatomy, Artistic', 'Education, Medical', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Japan', 'Medical Illustration'] | 17,396,567 | [['H01.158.100'], ['H01.158.100.091', 'K01.093.410.100'], ['I02.358.399'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['H02.385', 'J01.897.280.500.480', 'K01.093.410', 'L01.178.820.090.480']] | ['Disciplines and Occupations [H]', 'Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 |
A fatal case of malignant hyperthermia complicated by generalized compartment syndrome and rhabdomyolysis. | A healthy 21-year-old male who had previously been anaesthetized without complications underwent a laparotomy following a skiing accident. He developed severe malignant hyperthermia. The initial reaction was successfully treated with dantrolene, but during the following days the patient developed several compartment sy... | ['Adult', 'Anesthetics, Intravenous', 'Compartment Syndromes', 'Dantrolene', 'Fatal Outcome', 'Hemorrhage', 'Humans', 'Hyperkalemia', 'Laparotomy', 'Male', 'Malignant Hyperthermia', 'Muscle Relaxants, Central', 'Propofol', 'Renal Dialysis', 'Rhabdomyolysis'] | 12,699,524 | [['M01.060.116'], ['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['C05.651.180', 'C14.907.303'], ['D03.383.129.308.432.555.287'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pseudolinear C4d deposits in a hereditary glomerulopathy caused by a rare NC1 collagen-4-alpha-5 missense mutation: a "new disease entity"? | C4d positive glomerulopathies with pseudolinear capillary wall deposits caused by basement membrane (GBM) remodeling have sporadically been reported in renal transplants. Here we describe the case of a hypertensive 60 year-old male with a 5 month history of nephrotic range proteinuria in the setting of normal serum cre... | ['Collagen Type IV', 'Complement C4b', 'Glomerulonephritis, Membranous', 'Humans', 'Male', 'Middle Aged', 'Mutation, Missense', 'Peptide Fragments'] | 31,682,783 | [['D12.776.860.300.250.400.100'], ['D12.776.124.486.274.350.260'], ['C12.777.419.570.363.625', 'C13.351.968.419.570.363.625', 'C20.111.535'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05.365.590.650'], ['D12.644.541']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A highly sensitive immunoassay for atrazine based on covalently linking the small molecule hapten to a urea-glutaraldehyde network on a polystyrene surface. | A new enzyme-linked immunosorbent assay (ELISA) for atrazine was developed based on covalent bonding of the small molecule hapten, 2-mercaptopropionic acid-4-ethylamino-6-isopropylamino-1,3,5-triazine (MPA-atrazine), to urea-glutaraldehyde (UGA)-treated microtiter plates. In this assay, the microtiter plate surface was... | ['Atrazine', 'Environmental Pollutants', 'Enzyme-Linked Immunosorbent Assay', 'Glutaral', 'Haptens', 'Herbicides', 'Humans', 'Oryza', 'Polystyrenes', 'Reference Values', 'Sensitivity and Specificity', 'Sulfhydryl Compounds', 'Urea', 'Water', 'Zea mays'] | 27,743,554 | [['D03.383.931.247'], ['D27.888.284'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D02.047.532'], ['D23.050.550.480'], ['D27.720.031.700.366', 'D27.888.723.366'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.650.940.800.575.912.250.822... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Pediatric generalized joint hypermobility with and without musculoskeletal complaints: a localized or systemic disorder? | OBJECTIVES: Children with generalized hypermobility of the joints and musculoskeletal complaints frequently visit pediatric clinics, but many show no currently known collagen or other possibly related diseases. Whether the symptoms are confined to the musculoskeletal system is unknown. We assessed whether such children... | ['Anthropometry', 'Biomechanical Phenomena', 'Bone Density', 'Bone Diseases', 'Bone and Bones', 'Child', 'Comorbidity', 'Connective Tissue Diseases', 'Diagnosis, Differential', 'Diastole', 'Humans', 'Joint Instability', 'Muscle Contraction', 'Muscle, Skeletal', 'Muscular Diseases', 'Musculoskeletal Diseases', 'Physical... | 12,612,280 | [['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['G01.154.090', 'G01.374.089'], ['G11.427.100'], ['C05.116'], ['A02.835.232', 'A10.165.265'], ['M01.060.406'], ['N05.715.350.225', 'N06.850.490.687'], ['C17.300'], ['E01.171'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['B01.050.150.900.64... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vitro biomechanical study of female geriatric cervical vertebral bodies. | Compressive strength tests were conducted on fresh human geriatric female cervical vertebral bodies. Nineteen specimens were compressed to 50% of their initial height using an electrohydraulic testing device. The mechanical force-deflection response was sigmoidal with continuously changing resistance. The mean cross-se... | ['Aged', 'Aged, 80 and over', 'Aging', 'Biomechanical Phenomena', 'Bone Density', 'Cervical Vertebrae', 'Female', 'Humans', 'Reference Values'] | 2,319,771 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['G01.154.090', 'G01.374.089'], ['G11.427.100'], ['A02.835.232.834.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.810']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The daughter as the principal "double" in a Capgras' syndrome: psychodynamic correlates. | In a case of Capgras' syndrome the primary double is usually the spouse. In the described case, the patient chose as a double her pregnant 15-year-old daughter even though her spouse and four other children lived with her. A psychodynamic explanation for this choice is offered within the mechanism of the "ambivalence t... | ['Adolescent', 'Adult', 'Aggression', 'Capgras Syndrome', 'Combined Modality Therapy', 'Female', 'Haloperidol', 'Humans', 'Mother-Child Relations', 'Pregnancy', 'Psychotherapy', 'Psychotic Disorders', 'Violence'] | 3,812,829 | [['M01.060.057'], ['M01.060.116'], ['F01.145.126.125', 'F01.145.813.045'], ['F03.700.300'], ['E02.186'], ['D02.522.352.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290.170'], ['G08.686.784.769'], ['F04.754'], ['F03.700.675'], ['I01.198.240.856', 'I01.880.735.900']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Effect of M4-cholinoceptor blockade on haloperidol-produced catatonic syndrome in rats. | We studied the relationship between the efficiency of muscarinic receptor antagonists in preventing haloperidol-induced catatonia and their activity in tests for the interaction of ligands with various subtypes of muscarinic receptors (M1-M4) in rats. Mathematical modeling showed that affinity of the ligand for M4 rece... | ['Animals', 'Basal Ganglia Diseases', 'Catatonia', 'Haloperidol', 'Kinetics', 'Ligands', 'Male', 'Models, Biological', 'Muscarinic Antagonists', 'Pilocarpine', 'Rats', 'Receptor, Muscarinic M4', 'Receptors, Muscarinic', 'Syndrome'] | 15,273,762 | [['B01.050'], ['C10.228.140.079'], ['C10.597.606.115', 'C23.888.592.604.115', 'F01.145.126.156', 'F01.700.165'], ['D02.522.352.506'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.480'], ['E05.599.395'], ['D27.505.519.625.120.200.500', 'D27.505.696.577.120.200.500'], ['D03.132.672'], ['B01.050.150.900.649.313.992.635.5... | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reactive-electrospray-assisted laser desorption/ionization for characterization of peptides and proteins. | Electrospray-assisted laser desorption/ionization (ELDI) is a soft ionization method for mass spectrometry (MS) and combines features of both electrospray ionization (ESI) and matrix-assisted laser desorption/ionization to generate ESI-like multiply charged molecules. The ELDI process is based on merging ESI-generated,... | ['Amino Acid Sequence', 'Animals', 'Cattle', 'Disulfides', 'Dithiothreitol', 'Electron Transport', 'Gases', 'Glutathione', 'Insulin', 'Molecular Weight', 'Organic Chemicals', 'Peptides', 'Protein Conformation', 'Proteins', 'Sequence Analysis, Protein', 'Solvents', 'Spectrometry, Mass, Electrospray Ionization', 'Tandem ... | 18,683,952 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['D02.033.800.196', 'D02.886.740.224', 'D09.853.196'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['D01.362'], ['D12.644.456.448'], ['D06.472.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Multiple-center study of reduced-concentration triamcinolone topical solution for the treatment of dogs with known or suspected allergic pruritus. | OBJECTIVE: To determine the efficacy of triamcinolone acetonide topical solution (TTS) in dogs for use in reduction of clinical signs of pruritic inflammatory skin diseases of a known or suspected allergic basis and to evaluate adverse effects associated with TTS administration.ANIMALS: 103 pruritic adult dogs with kno... | ['Administration, Topical', 'Animals', 'Blood Chemical Analysis', 'Dog Diseases', 'Dogs', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Female', 'Glucocorticoids', 'Leukocyte Count', 'Male', 'Pruritus', 'Treatment Outcome', 'Triamcinolone Acetonide'] | 11,911,576 | [['E02.319.267.120'], ['B01.050'], ['E01.370.225.124.100', 'E05.200.124.100'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['E01.370... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Veterans have less age-related cognitive decline. | Military service involves exposure to a number of stresses, both psychological and physical. On the other hand, military personnel generally maintain excellent fitness, and veterans have increased access to education and health care. The overall effect on age-related cognitive decline, whether for good or ill, of havin... | ['Aged', 'Baltimore', 'Catchment Area, Health', 'Cognition Disorders', 'Educational Status', 'Female', 'Humans', 'Male', 'Mental Status Schedule', 'Middle Aged', 'Socioeconomic Factors', 'Surveys and Questionnaires', 'Veterans'] | 10,957,857 | [['M01.060.116.100'], ['Z01.107.567.875.500.500.100', 'Z01.433.100'], ['N01.224.791.200', 'N03.349.650.095', 'N06.850.505.400.800.200'], ['F03.615.250'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.603.500', 'F04.711.513.653.574'], ['M01.060.116.630'], ['I01.880.853.996', 'N01.824'],... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Singlet-Triplet Gaps of Cobalt Nitrosyls: Insights from Tropocoronand Complexes. | A density functional theory (DFT) study of {CoNO}(8) cobalt nitrosyl complexes containing the [n,n]tropocoronand ligand (TC-n,n) has revealed a sharp reduction of singlet-triplet gaps as the structures change from near-square-pyramidal (for n = 3) to trigonal-bipyramidal with an equatorial NO (for n = 5, 6). An experim... | ['Cobalt', 'Ligands', 'Macrocyclic Compounds', 'Models, Molecular', 'Molecular Conformation', 'Nitrogen', 'Organometallic Compounds', 'Quantum Theory'] | 26,203,786 | [['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['D27.720.470.480'], ['D04.345'], ['E05.599.595'], ['G02.111.570.820'], ['D01.268.604', 'D01.362.625'], ['D02.691'], ['H01.671.579.800']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Multiple fractures of the lower extremities (a propos of 50 patients)]. | According to a study of 50 multiple fractures of the lower limbs, the frequency of associated lesions justifies the creation of new multiple injury units, well equipped in which may be found specialists of all branches of surgery. Although internal fixation in one stage as an emergency, is ideal in all fractures, one ... | ['Adult', 'Ankle Joint', 'Ankylosis', 'Arthritis', 'Female', 'Fracture Fixation', 'Fracture Fixation, Internal', 'Fracture Fixation, Intramedullary', 'Fractures, Bone', 'Humans', 'Knee Joint', 'Leg Injuries', 'Male', 'Middle Aged', 'Pseudarthrosis'] | 1,176,563 | [['M01.060.116'], ['A02.835.583.378.062'], ['C05.550.069'], ['C05.550.114'], ['E04.555.300'], ['E04.555.300.300'], ['E04.555.300.300.300'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['C26.558'], ['M01.060.116.630'], ['C26.404.468.627']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Histamine inhibits neutrophil NADPH oxidase activity triggered by the lipoxin A4 receptor-specific peptide agonist Trp-Lys-Tyr-Met-Val-Met. | The vasoactive amine histamine is found at high concentrations in the immune and inflammatory tissues. Earlier studies have revealed that histamine regulates the nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase-dependent formation of oxygen radicals by phagocytic cells. However, the effects of histamine on i... | ['Chemotactic Factors', 'Cytoplasmic Granules', 'Down-Regulation', 'Enzyme Inhibitors', 'Histamine', 'Humans', 'N-Formylmethionine Leucyl-Phenylalanine', 'NADPH Oxidases', 'Neutrophils', 'Oligopeptides', 'Receptors, Cell Surface', 'Receptors, Formyl Peptide', 'Receptors, Lipoxin', 'Signal Transduction', 'Superoxides', ... | 12,950,678 | [['D23.125'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D27.505.519.389'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.886.030.676.450.440', 'D12.12... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo Cre/loxP mediated recombination in mouse Clara cells. | In small airways, Clara cells are the main epithelial cell type and play an important physiological role in surfactant production, protection against environmental agents, regulation of inflammatory and immune responses in the respiratory system. Thus, Clara cells are involved in lung homeostasis and pathologies like a... | ['Animals', 'Base Sequence', 'DNA, Recombinant', 'Epithelial Cells', 'Gene Expression', 'Genes, Reporter', 'Genetic Engineering', 'Integrases', 'Lung', 'Mice', 'Mice, Transgenic', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Recombination, Genetic', 'Respiratory System', 'Reverse Transcriptase Polymerase Chain React... | 16,245,155 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.460'], ['A11.436'], ['G05.297'], ['G05.360.340.024.340.435'], ['E05.393.420'], ['D08.811.739.500'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['G... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups. | BACKGROUND AND PURPOSE: von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in asymptomatic versus symptomatic carotid stenosis patients. The relationship b... | ['Aged', 'Biomarkers', 'Brain Ischemia', 'Carotid Stenosis', 'Endothelium', 'Humans', 'Intracranial Embolism', 'Ischemic Attack, Transient', 'Male', 'Middle Aged', 'Stroke', 'Ultrasonography', 'von Willebrand Factor'] | 24,712,648 | [['M01.060.116.100'], ['D23.101'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['A10.272.491'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.525.400', 'C14.907.253.566.300', 'C14.907.355.590.213.300'], ['C10.228.140.300.150.836... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Primary double pigtail stenting as a treatment of upper urinary tract leaks. | During a 5-year period 21 consecutive patients with iatrogenic or traumatic upper urinary tract leaks (nonmalignant) underwent treatment 5 to 28 days later with an indwelling double pigtail stent via an antegrade or retrograde approach. Six patients underwent initial nephrostomy drainage for relief of obstruction causi... | ['Adult', 'Catheters, Indwelling', 'Female', 'Humans', 'Iatrogenic Disease', 'Kidney Diseases', 'Male', 'Nephrostomy, Percutaneous', 'Stents', 'Ureteral Diseases', 'Urinary Catheterization', 'Urinary Fistula'] | 2,299,709 | [['M01.060.116'], ['E07.132.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.875'], ['C12.777.419', 'C13.351.968.419'], ['E01.370.390.550', 'E04.579.642', 'E04.950.774.739.500', 'E04.950.774.852.642'], ['E07.695.750'], ['C12.777.725', 'C13.351.968.725'], ['E01.370.390.820', 'E02.148.947', 'E05.157.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Art in Alzheimer's care: promoting well-being in people with late-stage Alzheimer's disease. | The purpose of this qualitative study was to explore the responses of people with late-stage Alzheimer's disease (AD) to a creative bonding intervention (CBI). The CBI consisted of simple art activities. Guided by Reed's self-transcendence theory, research questions were "Will persons with late-stage AD show evidence o... | ['Aged', 'Alzheimer Disease', 'Humans', 'Models, Nursing', 'Qualitative Research', 'Rehabilitation Nursing'] | 21,473,563 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.645'], ['H01.770.644.241.850'], ['H02.478.676.789', 'N02.421.533.889']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Exploration of CeO₂ nanoparticles as a chemi-sensor and photo-catalyst for environmental applications. | CeO₂ nanoparticles were synthesized hydrothermally and utilized as redox mediator for the fabrication of efficient ethanol chemi-sensor. The developed chemi-sensor showed an excellent performance for electrocatalytic oxidization of ethanol by exhibiting higher sensitivity (0.92 ìA?cm⁻²?mM⁻?) and lower limit of detectio... | ['Cerium', 'Environmental Monitoring', 'Environmental Pollutants', 'Nanoparticles', 'Photochemical Processes'] | 21,570,707 | [['D01.268.558.362.249', 'D01.552.550.399.249'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['J01.637.512.600'], ['G02.740']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Expanding the infection control team: development of the infection control liaison position for the neonatal intensive care unit. | Neonatal survival has risen progressively during the past 30 years. As the limits of viability continue to decline, the challenges of providing care to infants at the lowest extremes of gestational age and birth weight continually increase. Nosocomial infections in this very fragile population can be devastating. The c... | ['Cross Infection', 'Hospitals', 'Humans', 'Infant, Newborn', 'Infection Control', 'Intensive Care Units, Neonatal', 'Kentucky', 'Nursing Care', 'Patient Care Team', 'Risk Factors', 'Workforce'] | 11,988,713 | [['C01.248', 'C23.550.291.875.500'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N06.850.780.200.450'], ['N02.278.388.493.390.380'], ['Z01.107.567.875.075.400', 'Z01.107.567.875.510.400'], ['E02.760.611', 'N02.421.533'], ['N04.590.715'], ['E05.318.740.600.800.725', 'N05.715.... | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Comparison of interventional outcomes according to preoperative indication: a single center analysis of 2,240 limb revascularizations. | BACKGROUND: Outcomes after lower extremity revascularization are usually reported according to the level of peripheral arterial disease (PAD, aortoiliac or infrainguinal) or the method of treatment (open or endovascular surgery). Outcomes stratified by indication, ie, claudication or critical limb ischemia (rest pain a... | ['Adult', 'Aged', 'Angioplasty, Balloon', 'Female', 'Humans', 'Intermittent Claudication', 'Ischemia', 'Leg', 'Limb Salvage', 'Male', 'Middle Aged', 'Peripheral Vascular Diseases', 'Recovery of Function', 'Treatment Outcome', 'Vascular Patency', 'Vascular Surgical Procedures'] | 19,476,835 | [['M01.060.116'], ['M01.060.116.100'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.137.126.669', 'C23.888.531'], ['C23.550.513'], ['A01.378.610.500'], ['E04.100.814.603', 'E04.555.400', 'E04.680.350'], ['M01.060.116... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of remifentanil for general anesthesia on parturients and newborns undergoing cesarean section: a meta-analysis. | INTRODUCTION: The results presented by studies investigating the effect of remifentanil on both parturients and newborns during cesarean section differed significantly. Therefore, we performed a meta-analysis to estimate the effect of remifentanil on these patients.EVIDENCE ACQUISITION: Potentially eligible studies pub... | ['Analgesics, Opioid', 'Anesthesia, General', 'Cesarean Section', 'Female', 'Humans', 'Infant, Newborn', 'Pregnancy', 'Randomized Controlled Trials as Topic', 'Remifentanil'] | 28,492,294 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['E03.155.197'], ['E04.520.252.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A single session of meditation reduces of physiological indices of anger in both experienced and novice meditators. | The goal of the present study was to explore how anger reduction via a single session of meditation might be measured using psychophysiological methodologies. To achieve this, 15 novice meditators (Experiment 1) and 12 practiced meditators (Experiment 2) completed autobiographical anger inductions prior to, and followi... | ['Adolescent', 'Adult', 'Anger', 'Blood Pressure', 'Female', 'Heart Rate', 'Humans', 'Male', 'Meditation', 'Relaxation', 'Respiratory Rate', 'Young Adult'] | 26,748,026 | [['M01.060.057'], ['M01.060.116'], ['F01.470.093'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.374', 'E02.190.901.455', 'F04.754.137.750.500'], ['I03.450.769'], ['E01.370.600.875.875', 'G09.772.705.730'], ['M01.0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Alveolar band in patients with cleft lip and cleft alveolar deformities. | A complete cleft of the lip is often interrupted by a Simonarzt band. Very rarely, a similar fibrous soft tissue band can be seen interrupting the complete cleft of the alveolus. This alveolar band has not been previously described in the literature. | ['Alveolar Process', 'Cleft Lip', 'Cleft Palate', 'Female', 'Humans', 'Male'] | 23,524,819 | [['A02.835.232.781.324.502.125', 'A14.521.125', 'A14.549.167.646.094'], ['C07.465.409.225', 'C07.465.525.164', 'C07.650.525.164', 'C16.131.850.525.164'], ['C05.500.460.185', 'C05.660.207.540.460.185', 'C07.320.440.185', 'C07.465.525.185', 'C07.650.500.460.185', 'C07.650.525.185', 'C16.131.621.207.540.460.185', 'C16.131... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. | To date, no effective treatment for patients with advanced androgen-independent prostate cancer is available, whereas androgen ablation therapy, surgery, and radiation therapy are effective in treating local, androgen-dependent tumors. The mechanisms underlying the differences between androgen-dependent and -independen... | ['DNA-Binding Proteins', 'Down-Regulation', 'Gene Expression Regulation, Neoplastic', 'Humans', 'I-kappa B Proteins', 'Interleukin-6', 'Male', 'NF-kappa B', 'NF-kappa B p50 Subunit', 'Neoplasms, Hormone-Dependent', 'Phosphorylation', 'Promoter Regions, Genetic', 'Prostatic Neoplasms', 'Proto-Oncogene Proteins c-fos', '... | 12,727,841 | [['D12.776.260'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360.365', 'D12.776.260.420', 'D12.776.476.381', 'D12.776.930.326'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], ['D05.500.672', 'D12.776.260... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PcDWF1, a pear brassinosteroid biosynthetic gene homologous to AtDWARF1, affected the vegetative and reproductive growth of plants. | BACKGROUND: The steroidal hormones brassinosteroids (BRs) play important roles in plant growth and development. The pathway and genes involved in BR biosynthesis have been identified primarily in model plants like Arabidopsis, but little is known about BR biosynthesis in woody fruits such as pear.RESULTS: In this study... | ['Brassinosteroids', 'Flowers', 'Fruit', 'Gene Expression Regulation, Plant', 'Plant Proteins', 'Plants, Genetically Modified', 'Pyrus', 'Tobacco'] | 32,143,576 | [['D04.210.500.247.808.756.071', 'D10.570.938.795.071', 'D23.704.500.071'], ['A18.024.249.500'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['G05.308.375'], ['D12.776.765'], ['B01.650.520', 'B05.620.600'], ['B01.650.940.800.575.912.250.859.937.500.699'], ['B01.650.940.800.575.912.250.908.500.900']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
O2- and O4-ethylthymine and the ethylphosphotriester dTp(Et)dT are highly persistent DNA modifications in slowly dividing tissues of the ethylnitrosourea-treated rat. | Male Wistar rats received a single i.p. injection of [3H]ethylnitrosourea (140 mg/kg) and were killed after 2 h, 1, 3, 6, 28 or 56 days. DNA of the following organs was isolated and analysed for the presence of 12 different ethylated bases and ethylphosphotriesters: brain, lung, liver, spleen, kidney, intestine, testis... | ['Animals', 'Cell Division', 'DNA', 'DNA Damage', 'Dinucleoside Phosphates', 'Ethylnitrosourea', 'Kinetics', 'Male', 'Rats', 'Rats, Inbred Strains', 'Thymine', 'Thymine Nucleotides', 'Tissue Distribution'] | 3,608,071 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D13.444.308'], ['G05.200'], ['D13.695.250'], ['D02.065.950.594.310', 'D02.654.692.300'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers. | A monolithic molecularly imprinted polymer (monolithic MIP) was designed and prepared for chiral separation of nateglinide and its L-enantiomer. The enantiomers were rapidly separated on this novel monolithic MIP based chiral stationary phase (MIP-CSP), whereas the enantioseparation was not obtained on the non-imprinte... | ['Acrylic Resins', 'Chromatography, High Pressure Liquid', 'Cyclohexanes', 'Microscopy, Electron, Scanning', 'Nateglinide', 'Phenylalanine', 'Stereoisomerism', 'Thermodynamics'] | 16,196,134 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['E05.196.181.400.300'], ['D02.455.426.392.368.367'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D02.455.426.392.368.367.745', 'D12.125.072.050.685.448'], ['D12.125.072.050.685', 'D12.125.142.666'], ['G02.607.445.682'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Tuning the ion selectivity of glutamate transporter-associated uncoupled conductances. | The concentration of glutamate within a glutamatergic synapse is tightly regulated by excitatory amino acid transporters (EAATs). In addition to their primary role in clearing extracellular glutamate, the EAATs also possess a thermodynamically uncoupled Cl(-) conductance. This conductance is activated by the binding of... | ['Animals', 'Excitatory Amino Acid Transporter 1', 'Glutamic Acid', 'Humans', 'Ion Transport', 'Molecular Dynamics Simulation', 'Xenopus laevis'] | 27,296,367 | [['B01.050'], ['D12.776.157.530.200.249.500.500.500', 'D12.776.157.530.450.625.147.500', 'D12.776.157.530.562.374.781.500', 'D12.776.157.530.937.250.500.500', 'D12.776.543.585.200.249.500.500.500', 'D12.776.543.585.450.625.147.500', 'D12.776.543.585.562.374.781.500', 'D12.776.543.585.937.250.500.500'], ['D12.125.067.62... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Serial optical coherence tomography assessment of malapposed struts after everolimus-eluting stent implantation. A subanalysis from the HEAL-EES study. | BACKGROUND: Incomplete stent apposition (ISA) is related to stent thrombosis, which is a serious adverse event. We aim to assess the time-course of ISA after 2nd generation everolimus-eluting stent (EES) implantation.METHODS: In HEAL-EES study, we enrolled 36 patients who underwent percutaneous coronary intervention (P... | ['Aged', 'Cardiovascular Agents', 'Coronary Artery Disease', 'Coronary Thrombosis', 'Coronary Vessels', 'Drug-Eluting Stents', 'Everolimus', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neointima', 'Percutaneous Coronary Intervention', 'Predictive Value of Tests', 'Prosthesis Design', 'Randomized Controlled Trials as To... | 27,634,493 | [['M01.060.116.100'], ['D27.505.954.411'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['A07.015.114.269', 'A07.015.908.194'], ['E07.695.750.500'], ['D02.540.505.760.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue. | Ligand-based targeted delivery is an emerging platform in nanomedicine. We report herein on a peptide modified nanocarrier for a ligand-based targeted delivery system. The liposomal surface of the carrier was first modified with a linear peptide, followed by an adipose tissue-specific circular peptide (KGGRAKD) via a p... | ['Adipose Tissue', 'Animals', 'Cell Line', 'Cytoplasm', 'Drug Carriers', 'Drug Compounding', 'Endothelial Cells', 'Flow Cytometry', 'Ligands', 'Liposomes', 'Mice', 'Microscopy, Confocal', 'NIH 3T3 Cells', 'Nanoparticles', 'Obesity', 'Oligopeptides', 'Organ Specificity', 'Protein Binding'] | 20,647,023 | [['A10.165.114'], ['B01.050'], ['A11.251.210'], ['A11.284.430.214'], ['D26.255.260', 'E02.319.300.380'], ['E05.916.270'], ['A11.436.275'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D27.720.... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Autoregulation of RNA helicase expression in response to temperature stress in Synechocystis sp. PCC 6803. | RNA helicases are ubiquitous enzymes whose modification of RNA secondary structure is known to regulate RNA function. The pathways controlling RNA helicase expression, however, have not been well characterized. Expression of the cyanobacterial RNA helicase, crhR, is regulated in response to environmental signals that a... | ['Bacterial Proteins', 'Blotting, Northern', 'Blotting, Western', 'Cold Temperature', 'Gene Expression Regulation, Enzymologic', 'Half-Life', 'Heat-Shock Response', 'Homeostasis', 'Light', 'Mutation', 'RNA Helicases', 'RNA, Messenger', 'Stress, Physiological', 'Synechocystis', 'Temperature', 'Time Factors'] | 23,119,089 | [['D12.776.097'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G05.308... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleotide receptors activate cation, potassium, and chloride currents in a liver cell line. | By use of whole cell patch-clamp techniques, the effects of extracellular ATP on membrane ion currents of HTC cells from a rat liver tumor line were evaluated. ATP (500 microM) or the nonhydrolyzable analogue adenosine 5'-O-(3-thiotriphosphate) caused sequential activation of three currents: Icat (-1,325 +/- 255 pA at ... | ['Adenosine Triphosphate', 'Animals', 'Calcium', 'Cations', 'Chlorides', 'Electric Conductivity', 'Intracellular Membranes', 'Liver', 'Membrane Potentials', 'Nucleotides', 'Potassium', 'Rats', 'Receptors, Cell Surface', 'Terpenes', 'Thapsigargin', 'Tumor Cells, Cultured', 'Uridine Triphosphate'] | 8,178,992 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.248.497.300'], ['D01.210.450.150', 'D01.248.497.158.215'], ['G01.358.500.249.277'], ['A11.284.149.450', 'A11.284.835.514'], ['A03.620'], ['G01.154.535', 'G04.580', 'G... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
NKG2D modulates aggravation of liver inflammation by activating NK cells in HBV infection. | Hepatitis B virus (HBV) infection is thought to be an immune-mediated liver disease. The mechanisms underlying natural killer (NK) cell group 2D receptor (NKG2D) that activates NK cells and participates in anti-HBV immunity and immunopathology has not been thoroughly elucidated. Peripheral NKG2D+ and IFN-ã+ NK cells fr... | ['Adult', 'Coculture Techniques', 'Disease Progression', 'Female', 'Granzymes', 'Hep G2 Cells', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Interferon-gamma', 'Killer Cells, Natural', 'Liver', 'Male', 'Middle Aged', 'NK Cell Lectin-Like Receptor Subfamily K', 'Perforin', 'Prospective Studies', 'Tumor Necros... | 28,273,905 | [['M01.060.116'], ['E05.481.500.374'], ['C23.550.291.656'], ['D08.811.277.656.300.760.397', 'D08.811.277.656.959.350.397'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C06.55... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of Laparoscopic Approaches for Dismembered Pyeloplasty in Children With Ureteropelvic Junction Obstruction: Critical Analysis of 11-Year Experiences in a Single Surgeon. | OBJECTIVE: The choice of different laparoscopic approaches of laparoscopic pyeloplasty (LP) in children remains controversial. We present a comparison of different approaches of LP in children and a critical analysis of 11-year experiences in a single surgeon.MATERIALS AND METHODS: There were 1750 patients (1889 sides)... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Forecasting', 'Humans', 'Infant', 'Kidney Pelvis', 'Laparoscopy', 'Male', 'Operative Time', 'Reconstructive Surgical Procedures', 'Retroperitoneal Space', 'Retrospective Studies', 'Surgeons', 'Treatment Outcome', 'Ureter', 'Ureteral Obstruction... | 27,765,585 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['I01.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['A05.810.453.537'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E04.614.374.500', 'N02.421.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Consistent injury in the striatum of C57BL/6 mice after transient bilateral common carotid artery occlusion. | OBJECTIVE: The recent availability of transgenic mice enables us to study the functional role of single gene products in cerebral ischemia. To establish an experimental murine model of transient forebrain ischemia, this study examined the temporal profile of ischemic neuronal damage in the striatum after bilateral comm... | ['Animals', 'Apoptosis', 'Brain Ischemia', 'Brain Mapping', 'Carotid Stenosis', 'Corpus Striatum', 'Dominance, Cerebral', 'In Situ Nick-End Labeling', 'Ischemic Attack, Transient', 'Mice', 'Mice, Inbred C57BL', 'Necrosis', 'Neurons', 'Reperfusion Injury'] | 9,766,318 | [['B01.050'], ['G04.146.954.035'], ['C10.228.140.300.150', 'C14.907.253.092'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['A08.186.211.200.885.287.249.487'], ['F02.830.297', 'G11.561.225'], ['E05.393.475'], ['C10.228... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Liver histology and immunohistochemical findings in asymptomatic Indians with incidental detection of hepatitis B virus infection. | BACKGROUND AND OBJECTIVES: The relationship between hepatocyte expression of hepatitis B virus (HBV) antigens, liver histology and viral replication in asymptomatic subjects with incidental detection of hepatitis B surface antigen (HBsAg) remains unclear. We evaluated the histological activity index (HAI) and hepatocyt... | ['Adult', 'Alanine Transaminase', 'Biomarkers', 'DNA, Viral', 'Female', 'Hepatitis B Core Antigens', 'Hepatitis B Surface Antigens', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Hepatocytes', 'Humans', 'Immunohistochemistry', 'Incidental Findings', 'Liver', 'Male', 'Sensitivity and Specificity', 'Virus Replication'] | 16,877,824 | [['M01.060.116'], ['D08.811.913.477.700.100'], ['D23.101'], ['D13.444.308.568'], ['D23.050.327.495.500.450'], ['D23.050.327.495.500.475'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C06.552.380.705.437.100'], ['A11.43... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
[A new method of non-invasive determination of the cardiac minute volume in ventilated patients]. | A method for the determination of stroke volume and cardiac output from pulse-synchronized variations of pressure in mechanically ventilated patients is described. A comparison with 20 readings obtained by thermodilution showed good correlation (r = 0.9866). | ['Aged', 'Cardiac Output', 'Humans', 'Male', 'Middle Aged', 'Respiration, Artificial', 'Thermodilution'] | 1,741,905 | [['M01.060.116.100'], ['E01.370.370.380.150', 'G09.330.380.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['E05.484.750']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effects of HSP27 against UVB-induced photoaging in rat skin. | Skin photoaging refers to the phenomenon of skin aging or accelerated aging as a result of long-term UV exposure. Ultraviolet radiation can lead to DNA damage, cell apoptosis, cell growth inhibition and carcinogenic effects. Evidence suggests that hsp27 can protect cells from apoptosis induced by various stimuli in viv... | ['Animals', 'Apoptosis', 'Female', 'HSP27 Heat-Shock Proteins', 'Male', 'Oxidative Stress', 'Rats', 'Rats, Sprague-Dawley', 'Skin', 'Skin Aging', 'Ultraviolet Rays'] | 30,902,393 | [['B01.050'], ['G04.146.954.035'], ['D12.776.580.216.270.625'], ['G03.673', 'G07.775.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['A17.815'], ['G13.750.804'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.57... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Isolation and regulation of Sinorhizobium meliloti 1021 loci induced by oxygen limitation. | Eleven Sinorhizobium meliloti 1021 loci whose expression was induced under low oxygen concentrations were identified in a collection of 5,000 strains carrying Tn5-1063 (luxAB) transcriptional reporter gene fusions. The 11 Tn5-1063-tagged loci were cloned and characterized. The dependence of the expression of the tagged... | ['Amino Acid Sequence', 'Bacterial Proteins', 'DNA Transposable Elements', 'Gene Expression Regulation, Bacterial', 'Hemeproteins', 'Histidine Kinase', 'Luciferases', 'Luminescent Measurements', 'Molecular Sequence Data', 'Oxygen', 'Recombinant Fusion Proteins', 'Sinorhizobium meliloti', 'Symbiosis'] | 11,472,955 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['G05.308.300'], ['D12.776.422'], ['D08.811.913.696.620.682.424'], ['D08.811.682.517', 'D12.776.532.510'], ['E05.196.712.516'], ['L01.453.245.667'], ['D... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A study of fractional CO₂ laser resurfacing: the best fluences through a clinical, histological, and ultrastructural evaluation. | BACKGROUND: Fractional resurfacing is a laser treatment modality to create numerous microscopic thermal injury zones of controlled width, depth, and density that are surrounded by a reservoir of spared epidermal and dermal tissue, allowing rapid repair of laser-induced thermal injury.OBJECTIVE: To evaluate the safety a... | ['Collagen', 'Dermis', 'Dose Fractionation, Radiation', 'Epidermis', 'Female', 'Humans', 'Laser Therapy', 'Lasers, Gas', 'Middle Aged', 'Rejuvenation', 'Skin Aging', 'Treatment Outcome'] | 21,896,133 | [['D05.750.078.280', 'D12.776.860.300.250'], ['A17.815.180'], ['E02.815.639.200'], ['A10.272.497', 'A17.815.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['E07.632.490.367', 'E07.710.520.367'], ['M01.060.116.630'], ['E02.849'], ['G13.750.804'], ['E01.789.800', 'N04.761.559.590.800'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Apoptosis in v-myc transformation of myelomonocytic cells and its modulation by CSF-1. | c-myc is a proto-oncogene essential for cell growth. When activated, its expression can lead to uncontrolled cell proliferation, transformation and tumorigenesis. The cell line tEMmyc4 is a murine myelomonocytic cell line that was established following transformation by v-myc. It has a high level of v-myc expression an... | ['Animals', 'Apoptosis', 'Cell Division', 'Cell Survival', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Dexamethasone', 'Genes, myc', 'Growth Substances', 'Macrophage Colony-Stimulating Factor', 'Mice', 'Monocytes'] | 8,649,820 | [['B01.050'], ['G04.146.954.035'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.346'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G05.360.340.024.340.375.500.791.420'], ['D27.505.696.377'], ['D12.644.276.374.410.2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ICD defibrillation failure solved in an unusual fashion. | An implantable cardioverter defibrillator (ICD) is designed to sense life-threatening ventricular arrhythmias and terminate them, either by rapid pacing or by delivering an electrical shock. Nowadays it is a proven therapy for both primary and secondary prevention of sudden cardiac death. The typical configuration of a... | ['Adult', 'Defibrillators, Implantable', 'Humans', 'Male', 'Prosthesis Failure', 'Ventricular Fibrillation'] | 20,734,580 | [['M01.060.116'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767.865', 'E05.325.771'], ['C14.280.067.922', 'C23.550.073.922']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Rate-of-return guarantees for defined contribution plans. | This article explores the conceptual basis for an employer-backed minimum rate-of-return guarantee as an option under defined contribution plans. Expanding an earlier analysis, the author presents a prototype model of how the guarantee would work and discusses how it might be used for a mandatory Social Security define... | ['Employment', 'Financial Management', 'Humans', 'Investments', 'Liability, Legal', 'Pensions', 'Retirement', 'Salaries and Fringe Benefits', 'Social Security', 'United States'] | 11,258,155 | [['N01.824.245'], ['N03.219.463'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.702'], ['I01.880.604.583.490', 'N03.706.535.547'], ['N01.824.417.510'], ['I03.702'], ['N01.824.417.700', 'N04.452.677.800'], ['N03.219.521.346.506.849', 'N03.219.521.576.823'], ['Z01.107.567.875']] | ['Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Epidermodysplasia-verruciformis-like eruption associated with gamma-papillomavirus infection in a patient with adult T-cell leukemia. | Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by widespread and persistent cutaneous lesions caused by beta-papillomaviruses. Rare cases of acquired EV-like eruption associated with beta-papillomavirus infection have been reported in immunosuppressed patients. We report a case of acquired EV-li... | ['Biopsy', 'DNA, Viral', 'Diagnosis, Differential', 'Epidermodysplasia Verruciformis', 'Gammapapillomavirus', 'Humans', 'Leukemia-Lymphoma, Adult T-Cell', 'Male', 'Middle Aged', 'Papillomavirus Infections', 'Polymerase Chain Reaction', 'Skin'] | 19,696,474 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D13.444.308.568'], ['E01.171'], ['C01.925.256.650.810.345', 'C01.925.825.810.260', 'C01.925.928.914.345', 'C17.800.838.790.810.260'], ['B04.280.210.655.400', 'B04.613.204.655... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Body image differences among Malay, Samoan, and Australian women. | Comparisons of body attitudes and associated behaviours were undertaken using Malay, Samoan, and Australian female students. The general goal of the research was to determine the degree to which the observed pattern of attitudes and behaviours was attributable to culture. The specific analyses comprised an examination ... | ['Adult', 'Attitude to Health', 'Australia', 'Body Image', 'Body Mass Index', 'Body Weight', 'Cross-Cultural Comparison', 'Diet', 'Exercise', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Malaysia', 'Obesity', 'Samoa'] | 16,672,204 | [['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['Z01.639.100', 'Z01.678.100.373'], ['F01.752.747.792.110', 'F02.463.593.112'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The peptide HDEF as a new retention signal is necessary and sufficient to direct proteins to the endoplasmic reticulum. | The key feature of tomato RNase LX localised solely outside the vacuole is the C-terminal peptide HDEF which is very similar to known endoplasmic reticulum (ER) retention signals. For functional testing of the ER-targeting ability of HDEF, different constructs including the complete RNase LX, two truncated forms withou... | ['Amino Acid Sequence', 'Base Sequence', 'DNA Primers', 'Endoplasmic Reticulum', 'Endoribonucleases', 'Genes, Reporter', 'Lycopersicon esculentum', 'Oligopeptides', 'Protein Sorting Signals', 'Recombinant Fusion Proteins', 'Saccharomyces cerevisiae'] | 9,742,958 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['A11.284.430.214.190.875.248'], ['D08.811.277.352.355.350', 'D08.811.277.352.700.350'], ['G05.360.340.024.340.435'], ['B01.650.940.800.575.912.250.908.500.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Catecholamines decrease nitric oxide production by cytokine-stimulated hepatocytes. | BACKGROUND: Catecholamines are significantly elevated in inflammatory responses and play a regulatory role in sepsis. Nitric oxide (NO), also a key inflammatory mediator in sepsis, is produced in large amounts by the inducible nitric oxide synthase (iNOS) in the liver. The purpose of this study was to test the hypothes... | ['8-Bromo Cyclic Adenosine Monophosphate', 'Adenoviridae', 'Animals', 'Antineoplastic Agents', 'Biopterin', 'Cell Survival', 'Cells, Cultured', 'Cyclic AMP-Dependent Protein Kinase Type II', 'Cyclic AMP-Dependent Protein Kinases', 'Cytokines', 'Enzyme Inhibitors', 'Epinephrine', 'Gene Expression Regulation, Enzymologic... | 11,490,358 | [['D03.633.100.759.646.138.395.225', 'D13.695.462.200.225', 'D13.695.667.138.395.225', 'D13.695.827.068.395.225'], ['B04.280.030'], ['B01.050'], ['D27.505.954.248'], ['D03.633.100.733.631.202', 'D08.211.090'], ['G04.346'], ['A11.251'], ['D08.811.913.696.620.682.700.150.125.875', 'D12.644.360.200.125.875', 'D12.776.476.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of ACTH administration on liberation of testosterone by the Leydig cell (author's transl)]. | The possible r?le of the Leydig cells ithe changes of testosterone levels induced by ACTH administration is studied. 14 male Wistar rats weighing about 300 g were separated in two groups. One was treated with I mU.I./100 g/day of ACTH i.m. for 6 days and the other with saline solution as control Rats, testes and adrena... | ['Adrenal Glands', 'Adrenocorticotropic Hormone', 'Animals', 'Body Weight', 'Leydig Cells', 'Male', 'Organ Size', 'Rats', 'Stimulation, Chemical', 'Testosterone'] | 208,125 | [['A06.300.071'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.12... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation. | RNA interference (RNAi) technology has shown great promise for the treatment of cancer and other genetic disorders. Despite the efforts to increase the target tissue distribution, the safe and effective delivery of siRNA to the diseased cells with sufficient cytosolic transport is another critical factor for successful... | ['Animals', 'CDC2 Protein Kinase', 'Hep G2 Cells', 'Humans', 'Lipids', 'Liquid Crystals', 'Mice, Inbred BALB C', 'Mice, Nude', 'Nanoparticles', 'Neoplasms', 'RNA Interference', 'RNA, Messenger', 'RNA, Small Interfering', 'RNAi Therapeutics'] | 29,561,622 | [['B01.050'], ['D08.811.913.696.620.682.700.646.500.500.250', 'D08.811.913.696.620.682.700.646.500.984.500', 'D12.644.360.250.067.249', 'D12.644.360.250.580.500', 'D12.776.167.200.067.249', 'D12.776.167.200.580.500', 'D12.776.476.250.067.249', 'D12.776.476.250.580.500', 'D12.776.744.360'], ['A11.251.860.180.432', 'A11.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Tenfold population increase in Western Europe at the Neandertal-to-modern human transition. | European Neandertals were replaced by modern human populations from Africa ~40,000 years ago. Archaeological evidence from the best-documented region of Europe shows that during this replacement human populations increased by one order of magnitude, suggesting that numerical supremacy alone may have been a critical fac... | ['Animals', 'Archaeology', 'Fossils', 'France', 'Hominidae', 'Humans', 'Population Density', 'Population Dynamics', 'Population Growth', 'Time', 'Tool Use Behavior'] | 21,798,948 | [['B01.050'], ['I01.076.201.208'], ['I01.076.368.584.311'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.224.600', 'N06.850.505.400.600'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['I01.240.600.660', 'N01.224.625.660', 'N06.850.505.40... | ['Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Oral Polypodium Leucotomos Extract and Its Impact on Visible Light-Induced Pigmentation in Human Subjects | BACKGROUND: Visible light (VL) has multiple effects on the skin that currently available sunscreens do not protect against. Polypodium leucotomos extract (PLE) has properties that may offer protection against VL.
OBJECTIVES: To determine the effectiveness of PLE in preventing VL-induced effects.
METHODS: Twenty-two s... | ['Administration, Oral', 'Cyclooxygenase 2', 'Female', 'Humans', 'Hyperpigmentation', 'Light', 'Male', 'Plant Extracts', 'Polypodium', 'Skin Pigmentation'] | 31,859,468 | [['E02.319.267.100'], ['D08.811.600.720.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.621.430'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D20.215.784.500', 'D26.667'], ['B01.650.940.800.575.912.063.700.666'], ['E01.370.600.115.450.500', 'E01.370.600.620.750', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Manchester procedure: anatomical, subjective and sexual outcomes. | INTRODUCTION AND HYPOTHESIS: Classical native-tissue techniques for pelvic organ prolapse (POP) repairs, such as the Manchester procedure (MP), have been revitalized because of vaginal mesh complications. However, there are conflicting opinions regarding sufficient apical (mid-compartment) support by the MP and concern... | ['Dyspareunia', 'Female', 'Follow-Up Studies', 'Gynecologic Surgical Procedures', 'Humans', 'Norway', 'Organ Sparing Treatments', 'Pelvic Floor', 'Pelvic Organ Prolapse', 'Postoperative Complications', 'Prospective Studies', 'Quality of Life', 'Severity of Illness Index', 'Sexual Behavior', 'Surveys and Questionnaires'... | 29,532,126 | [['C12.294.644.242', 'C13.351.500.665.313', 'F03.835.199'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.950.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.816.374'], ['E02.674'], ['A01.923.600.600', 'A02.633.567.050.750'], ['C23.300.842.624'], ['C2... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
A case of Cushing syndrome secondary to ectopic adrenocorticotropic hormone producing carcinoid of the duodenum. | Cushing syndrome caused by adrenocorticotropic hormone (ACTH) production from solid tumors can result in life-threatening hypercortisolemia. Ectopic ACTH production is most commonly associated with bronchial carcinoids and squamous cell carcinoma of the lung. We report a case of Cushing syndrome caused by ectopic ACTH ... | ['ACTH Syndrome, Ectopic', 'Adult', 'Carcinoid Tumor', 'Cushing Syndrome', 'Duodenal Neoplasms', 'Female', 'Humans', 'Pancreaticoduodenectomy'] | 15,986,979 | [['C04.730.713.317'], ['M01.060.116'], ['C04.557.465.625.650.200', 'C04.557.470.200.025.200', 'C04.557.580.625.650.200'], ['C19.053.800.367'], ['C04.588.274.476.411.445', 'C06.301.371.411.445', 'C06.405.249.411.445', 'C06.405.469.275.270', 'C06.405.469.491.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.2... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Eight weeks of non-nightly use of zolpidem for primary insomnia. | CONTEXT: Intermittent use (i.e., a few nights per week) of hypnotic medication is often recommended for the treatment of chronic insomnia despite an absence of efficacy and safety data using this regimen.STUDY OBJECTIVES: To evaluate the clinical efficacy and safety of intermittent pharmacotherapy for chronic insomnia.... | ['Analysis of Variance', 'Double-Blind Method', 'Drug Administration Schedule', 'Humans', 'Hypnotics and Sedatives', 'Pyridines', 'Sleep Initiation and Maintenance Disorders', 'Surveys and Questionnaires', 'Time Factors', 'Zolpidem'] | 11,145,323 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.350', 'D27.505.954.427.210.350'], ['D03.383.725'], ['C10.886.425.800.800', 'F03.87... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mechanistic study of photo-oxidation of Bisphenol-A (BPA) with hydrogen peroxide (H2O2) and sodium persulfate (SPS). | The removal of Bisphenol-A (BPA) from contaminated water using advanced oxidation methods such as UV-C assisted oxidation by hydrogen peroxide (H2O2) and sodium persulfate (SPS) has been reported by the authors earlier (Sharma et al., 2015a). In the present study, the authors report the removal of BPA from aqueous solu... | ['Benzhydryl Compounds', 'Free Radicals', 'Gas Chromatography-Mass Spectrometry', 'Hydrogen Peroxide', 'Oxidants', 'Oxidation-Reduction', 'Phenols', 'Sodium Compounds', 'Sulfates', 'Ultraviolet Rays', 'Water Pollutants, Chemical', 'Water Purification'] | 26,468,603 | [['D02.455.426.559.389.115'], ['D01.339', 'D02.389'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D27.720.642', 'D27.888.569.540'], ['G02.700', 'G03.295.531'], ['D02.455.426.559.389.657'], ['D01.857'], ['D01.248.497.158.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations. | Atypical Parkinsonism associated with white matter pathology has been described in cerebrovascular diseases, mitochondrial cytopathies, osmotic demyelinating disorders, leukoencephalopathies leukodystrophies, and others. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an autosomal dominant disorder with... | ['Adolescent', 'Adult', 'Age of Onset', 'Aged', 'Antiparkinson Agents', 'Biological Specimen Banks', 'Brain', 'Family', 'Female', 'Gait Disorders, Neurologic', 'Gliosis', 'Humans', 'Hypokinesia', 'Image Processing, Computer-Assisted', 'Leukoencephalopathies', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Muscle... | 23,787,135 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['D27.505.954.427.090.050'], ['N02.278.065'], ['A08.186.211'], ['F01.829.263', 'I01.880.853.150'], ['C10.597.404', 'C23.888.592.413'], ['C23.550.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.350.4... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomen... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
The effect of erythropoietin on autologous stem cell-mediated bone regeneration. | Mesenchymal stem cells (MSCs) although used for bone tissue engineering are limited by the requirement of isolation and culture prior to transplantation. Our recent studies have shown that biomaterial implants can be engineered to facilitate the recruitment of MSCs. In this study, we explore the ability of these implan... | ['Animals', 'Bone Regeneration', 'Cell Differentiation', 'Cell Proliferation', 'Chemokines', 'Chemotaxis', 'Erythropoietin', 'Immunohistochemistry', 'Implants, Experimental', 'Mesenchymal Stem Cell Transplantation', 'Mesenchymal Stem Cells', 'Mice', 'Mice, Inbred BALB C', 'Osteogenesis', 'Skull', 'Tissue Scaffolds', 'T... | 23,831,188 | [['B01.050'], ['G11.427.213.140', 'G16.762.150.150'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bayesian network meta-analysis comparing five contemporary treatment strategies for newly diagnosed acute promyelocytic leukaemia. | Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. The optimum regimen for newly diagnosed APL remains inconclusive. In this Bayesian network meta-analysis, we compared the effectiveness of five regimens-arsenic trioxide (ATO) + all-trans retinoic acid (ATRA), realgar-indigo naturalis fo... | ['Bayes Theorem', 'Humans', 'Leukemia, Promyelocytic, Acute', 'Survival Analysis', 'Treatment Outcome'] | 27,322,078 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275.700'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Relevance of posttransplant flow cytometric T- and B-cell crossmatches in tacrolimus-treated renal transplant patients. | BACKGROUND: De novo development of anti-human leukocyte antigen (HLA) antibodies after transplantation is associated with increased rejection and decreased graft survival. In this study, the effect of posttransplant HLA antibodies on clinical outcome was evaluated in patients treated with tacrolimus by means of flow cy... | ['Adolescent', 'Adult', 'Aged', 'Antibodies', 'B-Lymphocytes', 'Female', 'Flow Cytometry', 'Graft Rejection', 'Graft Survival', 'HLA Antigens', 'Histocompatibility Testing', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies', 'T-Lymphocytes', 'Tac... | 17,102,764 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1. | Microsomal prostaglandin E(2) synthase (mPGES-1) represents a potential target for novel analgesic and anti-inflammatory agents. High-throughput screening identified several leads of mPGES-1 inhibitors which were further optimized for potency and selectivity. A series of inhibitors bearing a biaryl imidazole scaffold e... | ['Animals', 'Anti-Inflammatory Agents', 'Cell Line', 'Dinoprostone', 'High-Throughput Screening Assays', 'Imidazoles', 'Intramolecular Oxidoreductases', 'Mice', 'Microsomes', 'Prostaglandin-E Synthases'] | 20,965,723 | [['B01.050'], ['D27.505.954.158'], ['A11.251.210'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['E05.916.680'], ['D03.383.129.308'], ['D08.811.399.475'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.835.540'], ['D08.811.399.475.600']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Arylazoamidoximes and related compounds as NO-modulators. | Three amidinoarylhydrazines 1, three arylazoamidines 2, and nine arylazoamidoximes 3 have been synthesized and investigated for their potential to function as nitric oxide (NO) modulators. In-vitro studies demonstrated that 2 and 3 inhibited platelet aggregation (2c, IC(50 )= 3 microM) which could also be shown in vivo... | ['Animals', 'Blood Pressure', 'Fibrinolytic Agents', 'Nitric Oxide', 'Oximes', 'Platelet Aggregation Inhibitors', 'Rats', 'Rats, Inbred SHR', 'Structure-Activity Relationship', 'Vasodilator Agents'] | 19,921,683 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D02.092.570.665'], ['D27.505.954.502.780'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Remote reperfusion lung injury is associated with AMP deaminase 3 activation and attenuated by inosine monophosphate. | BACKGROUND: Remote reperfusion lung injury occurs in patients with vascular occlusion and surgical procedures. Inosine monophosphate (IMP) produced by adenosine monophosphate deaminase (AMPD) 3 is involved in the remote reperfusion injury. The purpose of the present study was to identify whether IMP administration atte... | ['AMP Deaminase', 'Animals', 'Disease Models, Animal', 'Enzyme Activation', 'Gene Expression Regulation, Enzymologic', 'Inosine Monophosphate', 'Lung', 'Lung Injury', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Muscle, Skeletal', 'Peroxidase', 'RNA, Messenger', 'Reperfusion Injury', 'Tumor Necrosis Factor-alpha'] | 17,384,464 | [['D08.811.277.151.653.060'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.263', 'G03.328'], ['G05.308.320'], ['D03.633.100.759.646.616.500', 'D13.695.667.616.500', 'D13.695.827.519.500'], ['A04.411'], ['C08.381.520', 'C26.891.554'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.19... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A new tremor mutant in the Pietrain pig: an animal model of orthostatic tremor? Clinical and neurophysiological observations. | A new tremor mutant, the "Campus syndrome" was studied in a breed of Pietrain pigs. Affected pigs showed a coarse tremor of the extremities when standing and walking, so they tended to remain recumbent, during which the tremor was suppressed. Needle electromyographic recordings of the semitendinosus muscle plus acceler... | ['Animals', 'Animals, Inbred Strains', 'Case-Control Studies', 'Disease Models, Animal', 'Electromyography', 'Extremities', 'Gait', 'Humans', 'Muscle, Skeletal', 'Neural Conduction', 'Observation', 'Oscillometry', 'Posture', 'Swine', 'Tremor', 'Ulnar Nerve', 'Videotape Recording'] | 9,380,058 | [['B01.050'], ['B01.050.050.199.520'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.405.255', 'E01.370.530.255'], ['A01.378'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Evaluating different criteria for defining a complete ambulatory blood pressure monitoring recording: data from the Jackson Heart Study. | OBJECTIVE: We determined differences in the prevalence of blood pressure (BP) phenotypes and the association of these phenotypes with left ventricular hypertrophy (LVH) for individuals who fulfilled and did not fulfill various criteria used for defining a complete ambulatory blood pressure monitoring (ABPM) recording.M... | ['Aged', 'Blood Pressure', 'Blood Pressure Monitoring, Ambulatory', 'Female', 'Humans', 'Hypertension', 'Hypertrophy, Left Ventricular', 'Male', 'Middle Aged', 'Photoperiod', 'White Coat Hypertension'] | 29,240,564 | [['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140.100', 'E01.370.520.500.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C14.280.195.400', 'C23.300.775.250.400'], ['M01.060.116.630'], ['G01.910.675'], ['C14.907.489.907']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Restoration of resistance to osmotic swelling of vitrified mouse embryos by short-term culture. | In cryopreservation of mammalian embryos, embryos can be injured by osmotic swelling during removal of the cryoprotectant after warming. We have shown that vitrified embryos are more sensitive to osmotic swelling than fresh cells but that sensitivity is reduced or abolished if vitrified cells are cultured for a short p... | ['Animals', 'Anti-Bacterial Agents', 'Brefeldin A', 'Cryopreservation', 'Cycloheximide', 'Cytochalasin B', 'Dactinomycin', 'Demecolcine', 'Embryo Transfer', 'Embryo, Mammalian', 'Macrolides', 'Mice', 'Osmotic Pressure', 'Protein Synthesis Inhibitors'] | 10,413,570 | [['B01.050'], ['D27.505.954.122.085'], ['D02.540.576.500.875'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['D03.383.621.808.240'], ['D03.633.100.473.231.370', 'D23.946.587.370.370'], ['D03.633.300.200', 'D04.345.56... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Study on the knowledge of and attitude to sexual dysfunction in aged men]. | OBJECTIVE: To investigate the knowledge of and attitude to sexual dysfunction in aged men, and to discuss the status and needs of male healthcare.METHODS: Two thousand seven hundred and twenty-eight men (40-70 years old) were surveyed on sexual dysfunction using the randomized questionnaire in Xicheng District, Beijing... | ['Adult', 'Aged', 'China', 'Coitus', 'Erectile Dysfunction', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Quality of Life', 'Surveys and Questionnaires'] | 16,281,508 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.252.474.164'], ['F01.145.802.188', 'G08.686.784.041'], ['C12.294.644.486', 'F03.835.400'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.52... | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
PET predicts prognosis after 1 cycle of chemotherapy in aggressive lymphoma and Hodgkin's disease. | UNLABELLED: Early identification of chemotherapy-refractory lymphoma patients provides a basis for alternative treatment strategies. Metabolic imaging with (18)F-FDG PET offers functional tissue characterization that is useful for assessing response to therapy. Our objective was to determine the predictive value of (18... | ['Antineoplastic Combined Chemotherapy Protocols', 'Female', 'Fluorodeoxyglucose F18', 'Follow-Up Studies', 'Hodgkin Disease', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Prognosis', 'Radiopharmaceuticals', 'Sensitivity and Specificity', 'Time Factors', 'Tomography, Emission-... | 12,163,626 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D09.254.229.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C04.557.386.355', 'C15.604.515.569.355', 'C20.683.515.761.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480', 'C15.604.515... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation. | The heterotrimeric G protein transducin is a key component of the vertebrate phototransduction cascade. Transducin is peripherally attached to membranes of the rod outer segment, where it interacts with other proteins at the membrane-cytosol interface. However, upon sustained activation by light, the dissociated G(t)al... | ['Animals', 'Humans', 'Lipid Bilayers', 'Models, Biological', 'Models, Molecular', 'Protein Structure, Quaternary', 'Protein Subunits', 'Protein Transport', 'Retinal Rod Photoreceptor Cells', 'Rhodopsin', 'Transducin'] | 18,782,760 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.570.510', 'J01.637.087.500.510'], ['E05.599.395'], ['E05.599.595'], ['G02.111.570.820.709.550'], ['D12.776.813'], ['G03.143.700'], ['A08.675.650.850.625.670.650', 'A08.675.650.915.937.670.650', 'A08.800.950.937.670.650', 'A09.371.729.831.625.670.650',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Coronary artery disease alters ventricular repolarization dynamics in type 2 diabetes. | Ventricular repolarization dynamics (VRD) is an important predictor of outcome in diabetes. We examined the potential impact of coronary artery disease (CAD) on VRD in type 2 diabetic patients. We recorded 5-minute high-resolution resting electrocardiograms in 38 diabetic patients undergoing elective coronary angiograp... | ['Case-Control Studies', 'Coronary Artery Disease', 'Diabetes Mellitus, Type 2', 'Diabetic Angiopathies', 'Double-Blind Method', 'Electrophysiology', 'Female', 'Heart Ventricles', 'Humans', 'Male', 'Middle Aged'] | 15,683,491 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C18.452.394.750.149', 'C19.246.300'], ['C14.907.320', 'C19.246.099.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['H01.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson's disease: An open prospective single institution study. | Numerous studies document significant improvement in motor symptoms in patients with Parkinson's disease (PD) after deep brain stimulation of the subthalamic nucleus (STN-DBS). However, little is known about the initial effects of STN-DBS on nonmotor domains.Our objective was to elucidate the initial effects of STN-DBS... | ['Adult', 'Aged', 'Deep Brain Stimulation', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Motor Activity', 'Parkinson Disease', 'Prospective Studies', 'Subthalamic Nucleus', 'Time Factors', 'Treatment Outcome'] | 29,384,860 | [['M01.060.116'], ['M01.060.116.100'], ['E02.331.300', 'E04.190'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.632', 'G11.427.410.698'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Antiviral activity of bacteria-derived human alpha interferons against encephalomyocarditis virus infection of mice. | Bacteria-derived human leukocyte interferon (IFN) subtypes, IFN-alpha A, -alpha B, and -alpha D, and two hybrid IFNs, IFN-alpha AD and -alpha DA, were examined for both in vitro and in vivo antiviral activity. Two of these materials in highly purified form (IFN-alpha D and -alpha D) protect mice against lethal doses of... | ['Animals', 'Cattle', 'Cell Line', 'Cloning, Molecular', 'Encephalomyocarditis virus', 'Enterovirus Infections', 'Escherichia coli', 'Female', 'Humans', 'Interferons', 'Mice', 'Plasmids', 'Time Factors'] | 6,173,327 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251.210'], ['E05.393.220'], ['B04.820.578.750.170.200'], ['C01.925.782.687.359'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440', 'D12.776.467.374.440', 'D23.529.374.440'], ['B01... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease. | BACKGROUND: Dementia patients with anosmia are more likely to have Lewy body pathology at postmortem, but clinicopathological studies have only assessed olfaction in moderate dementia or an average of 5 years before death. It is not known whether, in patients with mild dementia (MMSE score over 20), olfactory function ... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Cognition Disorders', 'Diagnosis, Differential', 'Female', 'Humans', 'Lewy Body Disease', 'Male', 'Mental Status Schedule', 'Olfaction Disorders', 'Point-of-Care Systems', 'ROC Curve', 'Sensory Thresholds'] | 19,448,090 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['F03.615.250'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.079.862.400', 'C10.228.140.380.422', 'C10.228.662.600.200', 'C10.574.928.500', 'F03.615.400.512'], ['F04.711.513.603.... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The diagnosis of pelviureteric junction obstruction. | The distinction between a dilated upper urinary tract which is obstructed and a dilated but unobstructed system is of fundamental importance. This differentiation may be difficult to make with methods of diagnosis currently available. Standard intravenous urography provides good morphological information about the coll... | ['Follow-Up Studies', 'Humans', 'Kidney', 'Kidney Pelvis', 'Postoperative Period', 'Radiography', 'Radionuclide Imaging', 'Ureteral Obstruction', 'Urinary Bladder', 'Urodynamics'] | 7,436,292 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['A05.810.453.537'], ['E04.614.750', 'N02.421.585.753.750'], ['E01.370.350.700'], ['E01.370.350.710', 'E01.370.384.730'], ['C12.777.725.776', 'C13.351.968.725.776... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Risk factors for community-acquired pneumonia in immunocompetent seniors. | OBJECTIVES: To identify risk factors for developing community-acquired pneumonia (CAP) in seniors.DESIGN: Nested case-control study.SETTING: Group Health, a health maintenance organization in Washington state.PARTICIPANTS: One thousand one hundred seventy-three immunocompetent seniors with CAP and 2,346 age- and sex-ma... | ['Aged', 'Aged, 80 and over', 'Body Weight', 'Cardiovascular Diseases', 'Case-Control Studies', 'Community-Acquired Infections', 'Female', 'Frail Elderly', 'Humans', 'Influenza, Human', 'Logistic Models', 'Male', 'Pneumonia', 'Risk Assessment', 'Risk Factors', 'Washington', 'Weight Loss'] | 19,453,307 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C14'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C01.234'], ['M01.060.116.100.540'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Pro inflammatory interleukins and thyroid function in Naswar (dipping tobacco) users: a case control study. | BACKGROUND: Naswar is a type of finely ground, moistened smokeless dipping tobacco product being commonly used in Pakistan. Although, nicotine is the most important psychoactive agent present in Naswar, it also exerts immunosuppressive effects and could alter the levels of cytokines. Additionally, the effects of Naswar... | ['Adolescent', 'Adult', 'Humans', 'Interleukin-1beta', 'Interleukin-6', 'Male', 'Pakistan', 'Thyroid Function Tests', 'Thyroid Gland', 'Thyrotropin', 'Thyroxine', 'Tobacco Use', 'Triiodothyronine'] | 27,515,932 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.600', 'D12.776.467.374.465.010.600', 'D12.776.467.374.500.400.600', 'D23.529.374.465.131.600', 'D23.529.374.500.400.600'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', '... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Impact of Sarcopenic Obesity on Failure to Rescue from Major Complications Following Pancreaticoduodenectomy for Cancer: Results from a Multicenter Study. | BACKGROUND: Failure to rescue (FTR) is a quality-of-care indicator in pancreatic surgery, but may also identify patients who may not tolerate major postoperative complications despite being treated with best available care. Previous studies found that high visceral adipose tissue-to-skeletal muscle ratio is associated ... | ['Abdominal Muscles', 'Aged', 'Aged, 80 and over', 'Anastomotic Leak', 'Failure to Rescue, Health Care', 'Female', 'Health Status', 'Humans', 'Intra-Abdominal Fat', 'Male', 'Obesity', 'Pancreatic Fistula', 'Pancreatic Neoplasms', 'Pancreaticoduodenectomy', 'Postoperative Hemorrhage', 'Preoperative Period', 'Retrospecti... | 29,116,490 | [['A02.633.567.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.767.071'], ['E01.789.800.760.500', 'H01.770.644.145.431.500', 'N04.761.559.590.800.760.500', 'N05.715.360.575.575.800.760.500'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.165... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
mda-7/IL-24 expression inhibits breast cancer through upregulation of growth arrest-specific gene 3 (gas3) and disruption of â1 integrin function. | Melanoma differentiation-associated gene (MDA)-7)/interleukin (IL)-24, a member of the IL-10 family of cytokines, inhibits growth of various human cancer cells, yet the underlying mechanism is largely unknown. Here, we report that mda-7/IL-24 efficiently suppresses the development of rat mammary tumors in vivo. Microar... | ['Adenoviridae', 'Animals', 'Breast Neoplasms', 'Carcinogenesis', 'Cell Adhesion', 'Cell Line, Tumor', 'Cell Proliferation', 'Female', 'Fibronectins', 'Gene Expression Regulation, Neoplastic', 'Glycosylation', 'Humans', 'Integrin beta1', 'Interleukins', 'Ligands', 'Mammary Neoplasms, Animal', 'Mice', 'Mice, Nude', 'Mut... | 23,468,528 | [['B04.280.030'], ['B01.050'], ['C04.588.180', 'C17.800.090.500'], ['C04.697.098', 'C23.550.727.098'], ['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['G05.308.370'], ['G02.111.158... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Electron spin resonance and electron-spin-echo study of oriented multilayers of L alpha-dipalmitoylphosphatidylcholine water systems. | A detailed electron spin resonance (ESR) study of spin-labeled-oriented multilayers of L alpha-dipalmitoylphosphatidylcholine (DPPC) water systems for low water content (2-10% by weight) is reported with the purpose of characterizing the dynamical and structural properties of model membrane systems. Emphasis is placed ... | ['Electron Spin Resonance Spectroscopy', 'Liposomes', 'Molecular Conformation', 'Pulmonary Surfactants', 'Thermodynamics', 'Water'] | 2,996,648 | [['E05.196.867.519.274'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['G02.111.570.820'], ['D27.505.954.796.600'], ['G01.906'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of intravenous methylprednisolone on the number, size and confluence of plaques in relapsing-remitting multiple sclerosis. | The aim of the present study was to evaluate whether intravenous methylprednisolone (IVMP) pulses affect the confluence and enlargement of T2 lesions in the long term in patients with relapsing-remitting (RR) multiple sclerosis (MS). Of 88 RR MS patients, randomly assigned to regular pulses of IVMP (1 g/day for 5 days ... | ['Adolescent', 'Adult', 'Anti-Inflammatory Agents', 'Central Nervous System', 'Disease Progression', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Female', 'Humans', 'Injections, Intravenous', 'Magnetic Resonance Imaging', 'Male', 'Methylprednisolone', 'Middle Aged', 'Multiple Sclerosis, Relapsin... | 17,945,260 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.158'], ['A08.186'], ['C23.550.291.656'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['E01.370.350.825.500'], ['D04.210.500.745.432.769.795.539'], ['M01.060.116.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Validation of the HEM-780REL with easy wrap cuff for self-measurement of blood pressure according to the European Society of Hypertension International Protocol. | OBJECTIVE: We tested the accuracy of the HEM-780REL automatic blood pressure monitor with Easy Wrap Cuff.METHODS: We used the International Protocol for validation of blood pressure measuring devices developed by the Working Group on Blood Pressure Monitoring of the European Society of Hypertension. Thirty-three adults... | ['Adult', 'Blood Pressure', 'Blood Pressure Determination', 'Blood Pressure Monitoring, Ambulatory', 'Blood Pressure Monitors', 'Diastole', 'Europe', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Reference Values', 'Reproducibility of Results', 'Societies, Medical', 'Systole'] | 17,890,973 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140', 'E01.370.600.100'], ['E01.370.370.140.100', 'E01.370.520.500.100'], ['E07.230.740.100'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An AFLP estimation of the outcrossing rate of Spondias tuberosa (Anacardiaceae), an endemic species to the Brazilian semiarid region. | The umbu tree (Spondias tuberosa) is one of the most important endemic species to the Brazilian tropical semiarid region. The umbu tree has edible fruits with a peculiar flavor that are consumed in natura or in a semi-industrialized form, such as jams, candies and juices. The majority of endemic species to Brazilian se... | ['Amplified Fragment Length Polymorphism Analysis', 'Anacardiaceae', 'Brazil', 'Crosses, Genetic', 'Inbreeding'] | 23,885,576 | [['E05.393.290.382', 'E05.393.620.500.324'], ['B01.650.940.800.575.912.250.044'], ['Z01.107.757.176'], ['E05.393.281'], ['E05.820.150.520', 'G05.090.403']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Innovative Nanosensor for Disease Diagnosis. | As a futuristic diagnosis platform, breath analysis is gaining much attention because it is a noninvasive, simple, and low cost diagnostic method. Very promising clinical applications have been demonstrated for diagnostic purposes by correlation analysis between exhaled breath components and specific diseases. In addit... | ['Biosensing Techniques', 'Breath Tests', 'Catalysis', 'Diagnosis', 'Humans', 'Nanotechnology'] | 28,481,075 | [['E05.601.043'], ['E01.370.100'], ['G02.130'], ['E01'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.603', 'J01.897.520.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Coronavirus (COVID-19) outbreak: what the department of endoscopy should know. | Italy recorded its first case of confirmed acute respiratory illness because of coronavirus on February 18, 2020, soon after the initial reports in China. Since that time, Italy and nations throughout the world have adopted very stringent and severe measures to protect populations from spread of infection. Despite thes... | ['Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Endoscopy', 'Humans', 'Infection Control', 'Infectious Disease Transmission, Patient-to-Professional', 'Pandemics', 'Personal Protective Equipment', 'Pneumonia, Viral', 'SARS-CoV-2'] | 32,179,106 | [['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.450... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Structural investigations of neuromelanin by pyrolysis-gas chromatography/mass spectrometry. | Pyrolysis combined with gas chromatography and mass spectrometry (Py-GC/MS) was applied for structural investigations of the human substantia nigra neuromelanin. Using synthetic neuromelanins, we have demonstrated that Py-GC/MS is suitable for identification and differentiation of both eumelanin (dopamine-derived) and ... | ['Gas Chromatography-Mass Spectrometry', 'Humans', 'Melanins', 'Pigments, Biological', 'Substantia Nigra'] | 16,755,376 | [['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.072.050.875.379', 'D23.767.620'], ['D23.767'], ['A08.186.211.132.659.413.656']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sequence and comparative genomic analysis of actin-related proteins. | Actin-related proteins (ARPs) are key players in cytoskeleton activities and nuclear functions. Two complexes, ARP2/3 and ARP1/11, also known as dynactin, are implicated in actin dynamics and in microtubule-based trafficking, respectively. ARP4 to ARP9 are components of many chromatin-modulating complexes. Conventional... | ['Actins', 'Animals', 'Conserved Sequence', 'Genome', 'Internet', 'Mice', 'Models, Molecular', 'Mutagenesis, Insertional', 'Nucleic Acid Hybridization', 'Phylogeny', 'Protein Conformation', 'Protein Folding', 'Protein Structure, Secondary', 'Sequence Deletion'] | 16,195,354 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['G02.111.570.580'], ['G05.360.340'], ['L01.224.230.110.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595'], ['E05.393.420.601.550', 'G05.365.590.575', 'G05.558.550'], ['E05.393.661', 'G02.111.611'], ['G05.697', 'G16.07... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
In Vitro Description of Macroscopic Changes of Dental Amalgam Discs Subject to High Temperatures to Forensic Purposes. | OBJECTIVE: To describe the behavior of 45 discs of dental amalgam of known dimension prepared from three commercially available brands of dental amalgam (Contour® Kerr®-USA, Admix® SDI®-Australia and Nu Alloy® Newstethic®-Colombia) when subjected to the action of high temperatures (200 °C, 400 °C, 600 °C, 800 °C, 1000 ... | ['Cross-Sectional Studies', 'Dental Amalgam', 'Forensic Dentistry', 'Hot Temperature', 'Humans', 'In Vitro Techniques', 'Materials Testing', 'Microscopy'] | 26,851,445 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D25.339.208.291', 'J01.637.051.339.208.291'], ['H02.163.285', 'I01.198.780.875'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Color vision in attention-deficit/hyperactivity disorder: a pilot visual evoked potential study. | BACKGROUND: Individuals with attention-deficit/hyperactivity disorder (ADHD) are reported to manifest visual problems (including ophthalmological and color perception, particularly for blue-yellow stimuli), but findings are inconsistent. Accordingly, this study investigated visual function and color perception in adole... | ['Adolescent', 'Analysis of Variance', 'Attention Deficit Disorder with Hyperactivity', 'Case-Control Studies', 'Color Perception', 'Contrast Sensitivity', 'Evoked Potentials, Visual', 'Female', 'Humans', 'Male', 'Photic Stimulation', 'Pilot Projects', 'Refraction, Ocular', 'Visual Acuity'] | 25,435,188 | [['M01.060.057'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F03.625.094.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['F02.463.593.932.217'], ['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability. | Deubiquitylating enzymes (DUBs) enhance the dynamics of the versatile ubiquitin (Ub) code by reversing and regulating cellular ubiquitylation processes at multiple levels. Here we discovered that the uncharacterized human protein ZUFSP (zinc finger with UFM1-specific peptidase domain protein/C6orf113/ZUP1), which has b... | ['Binding Sites', 'Bone Neoplasms', 'Cell Line, Tumor', 'DNA Damage', 'Deubiquitinating Enzymes', 'Genomic Instability', 'HEK293 Cells', 'Humans', 'Lysine', 'Osteosarcoma', 'Polyubiquitin', 'Protein Binding', 'Protein Interaction Domains and Motifs', 'Retinal Pigment Epithelium', 'Substrate Specificity', 'Ubiquitinatio... | 29,576,528 | [['G02.111.570.120'], ['C04.588.149', 'C05.116.231'], ['A11.251.210.190', 'A11.251.860.180'], ['G05.200'], ['D08.811.037'], ['C23.550.362', 'G05.365.590.335', 'G05.370'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], [... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pneumonia associated with aspiration following stroke. | OBJECTIVE: To determine the association between demonstrated aspiration and pneumonia in stroke patients.METHODS: Chart review of 441 consecutive stroke patients admitted to a stroke rehabilitation unit within 4 months of their stroke over an 8-year period. Videofluoroscopic modified barium swallow (VMBS) was performed... | ['Acute Disease', 'Barium Sulfate', 'Cerebrovascular Disorders', 'Fluoroscopy', 'Humans', 'Incidence', 'Pneumonia, Aspiration', 'Retrospective Studies', 'Risk Factors', 'Videotape Recording'] | 8,669,999 | [['C23.550.291.125'], ['D01.103.075', 'D01.875.800.800.850.075'], ['C10.228.140.300', 'C14.907.253'], ['E01.370.350.700.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C01.748.610.529', 'C08.381.6... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Internal Structure Analysis of a Tobacco Control Network on the U.S.-M?xico Border. | Tobacco control (TC) networks (in which multiple agencies collaborate) are essential components within comprehensive TC efforts. The aim of this study was to assess the internal coalition outcomes hierarchy model (via the Internal Coalition Effectiveness [ICE] scale) in the present sample. Participants (members of a TC... | ['Analysis of Variance', 'Cooperative Behavior', 'Health Promotion', 'Humans', 'Interinstitutional Relations', 'Mexico', 'Surveys and Questionnaires', 'Texas', 'Tobacco Industry', 'Tobacco Use Cessation', 'United States'] | 25,384,580 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.145.813.115'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.822.400'], ['Z01.107.567.589'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['Z01.107.567.875.760.750'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Immunosuppressive therapies after intestinal transplant modulate the expression of Th1 signature genes during acute cellular rejection. Implications in the search for rejection biomarkers. | BACKGROUND AND AIMS: Acute cellular rejection (ACR) and infections are leading causes of graft loss and death in intestinal transplant patients. Our aim was to evaluate the impact of maintenance immunosuppressive therapies on the expression of pro-inflammatory mediators in small bowel at ACR diagnosis.MATERIALS AND MET... | ['Adult', 'Biomarkers', 'Case-Control Studies', 'Chemokine CXCL10', 'Chemokine CXCL11', 'Female', 'Follow-Up Studies', 'Graft Rejection', 'Humans', 'Immunosuppressive Agents', 'Interferon-gamma', 'Intestinal Diseases', 'Intestine, Small', 'Male', 'Postoperative Complications', 'Prognosis', 'Real-Time Polymerase Chain R... | 25,251,331 | [['M01.060.116'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.644.276.374.200.120.500', 'D12.776.467.374.200.120.500', 'D23.125.300.120.500', 'D23.469.200.120.500', 'D23.529.374.200.120.500'], ['D12.644.276.374.200.120.550', 'D12.776.467.374.200.120.550', 'D23.125.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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