Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells. | Deregulation of the phosphatidyl inositol trisphosphate kinase/AKT/mammalian target of rapamycin (mTOR) and RAS/mitogen-activated protein kinase (MAPK)/MNK pathways frequently occurs in human prostate carcinomas (PCas) and leads to aberrant modulation of messenger RNA (mRNA) translation. We have investigated the relati... | ['Adenosine Triphosphatases', 'Biomarkers, Tumor', 'Blotting, Western', 'Cation Transport Proteins', 'Cell Cycle', 'Cell Line, Tumor', 'Cell Proliferation', 'Copper-Transporting ATPases', 'Enzyme Inhibitors', 'Eukaryotic Initiation Factor-4E', 'Humans', 'Male', 'Mitogen-Activated Protein Kinases', 'Phosphorylation', 'P... | 18,809,972 | [['D08.811.277.040.025'], ['D23.101.140'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.277.040.025.314.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Temporal variations of skin pigmentation in C57BL/6 mice affect optical bioluminescence quantitation. | PURPOSE: Depilation-induced skin pigmentation in C57Bl/6 mice is a known occurrence, and presents a unique problem for quantitative optical imaging of small animals, especially for bioluminescence. The work reported here quantitatively investigated the optical attenuation of bioluminescent light due to melanin pigmenta... | ['Animals', 'Female', 'Hair Removal', 'Imaging, Three-Dimensional', 'Luminescent Measurements', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Optics and Photonics', 'Phantoms, Imaging', 'Sex Characteristics', 'Skin', 'Skin Pigmentation', 'Spectrum Analysis', 'Time Factors'] | 20,960,234 | [['B01.050'], ['E02.218.372'], ['E01.370.350.400', 'L01.224.308.410'], ['E05.196.712.516'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['H01.671.617', 'J01.293.688'], ['E07.671'], ['G08.686.815'], ['A17.815'], ['E01.370.600.115.450.50... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Integrative cognitive-behavioral and spiritual counseling for rural dementia caregivers with depression. | OBJECTIVE: Discuss initial evaluation of a program for training faith community nurses (FCNs) to conduct cognitive-behavioral and spiritual counseling (CBSC) for rural dementia caregivers (CGs), and present 2 case studies on the use of CBSC for treating depression in this population.STUDY DESIGN: Pre-post evaluation of... | ['Adaptation, Psychological', 'Adult', 'Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Caregivers', 'Cognitive Behavioral Therapy', 'Combined Modality Therapy', 'Communication', 'Community Health Nursing', 'Cost of Illness', 'Depressive Disorder', 'Female', 'Follow-Up Studies', 'Humans', 'Inservice Training', 'Male'... | 19,929,127 | [['F01.058'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F04.754.137.350'], ['E02.186'], ['F01.145.209', 'L01.143'], ['H02.478.676.150', 'N02.421.143.150'], ['N03.219.151.165', 'N05.715.36... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Kinevac (sincalide for injection)/Squibb Diagnostics. | Sincalide is a rapid-acting, synthetic analog of cholecystokinin for intravenous use in postevacuation cholecystography. Serious reactions to sincalide have not been reported. The intravenous administration of sincalide causes a prompt contraction of the gallbladder as compared to the stimulus of a fatty meal which cau... | ['Cholecystography', 'Humans', 'Sincalide'] | 1,932,168 | [['E01.370.350.700.715.210', 'E01.370.372.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.317.152.700', 'D12.644.120.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ultra-short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy. | We demonstrate the feasibility of using ultra-short echo time (TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High-performance outer volume suppression and pre-localization were demonstrated in phantoms and by the total absence of signals arising from e... | ['Animals', 'Glioma', 'Lipids', 'Magnetic Resonance Spectroscopy', 'Male', 'Rats', 'Rats, Wistar', 'Time Factors'] | 16,523,527 | [['B01.050'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['D10'], ['E05.196.867.519'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['G01.910.857']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modeling clinical outcome using multiple correlated functional biomarkers: A Bayesian approach. | In some biomedical studies, biomarkers are measured repeatedly along some spatial structure or over time and are subject to measurement error. In these studies, it is often of interest to evaluate associations between a clinical endpoint and these biomarkers (also known as functional biomarkers). There are potentially ... | ['Adenomatous Polyposis Coli Protein', 'Bayes Theorem', 'Biomarkers', 'Colorectal Neoplasms', 'Humans', 'Research Design', 'Risk', 'Transforming Growth Factor alpha'] | 23,070,593 | [['D05.500.117.249', 'D12.776.220.040', 'D12.776.476.081.249', 'D12.776.624.776.010'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['D23.101'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Gas chromatographic determination of cyprodinil, fludioxonil, pyrimethanil, and tebuconazole in grapes, must, and wine. | A rapid and simple gas chromatographic method for determinating cyprodinil, fludioxonil, pyrimethanil, and tebuconazole in grapes, must, and wine is described. An on-line microextraction method was used with a one-step extraction-partition procedure. Nitrogen-phosphorus and mass spectrometric detectors were used, becau... | ['Chromatography, Gas', 'Dioxoles', 'Food Analysis', 'Fruit', 'Fungicides, Industrial', 'Gas Chromatography-Mass Spectrometry', 'Nitrogen', 'Pesticide Residues', 'Phosphorus', 'Pyrimidines', 'Pyrroles', 'Reference Standards', 'Reproducibility of Results', 'Triazoles', 'Wine'] | 9,241,848 | [['E05.196.181.349'], ['D03.383.246'], ['E05.362', 'J01.576.423.850.100'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['D27.720.031.700.288', 'D27.888.723.288'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D01.268.604', 'D01.362.625'], ['D27.720.031.700.672', 'D27.888.723.697', 'N06.850.460.200.700'], ['D01.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The value of the captopril test and the effect of captopril on renal function. | We have investigated the use of captopril as a screening test for renovascular hypertension and compared the effects of captopril on renal function in patients with renovascular hypertension and those without renovascular hypertension. The captopril test and kidney gamma scintigraphy were carried out in 50 hypertensive... | ['Adult', 'Blood Pressure', 'Captopril', 'Glomerular Filtration Rate', 'Humans', 'Hypertension, Renovascular', 'Kidney', 'Radioisotope Renography', 'Renin'] | 2,187,090 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D12.125.072.401.623.270'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.331.490', 'C13.351.968.419.331.490', 'C14.907.489.631.485'], ['A05.810.453'], ['E01.370.350.710.715.700', 'E01.370.384.730.715... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Intakes of nutrients and nutritional status in coeliac patients. | BACKGROUND: The intake of nutrients and the nutritional status of untreated coeliac patients and coeliac patients in remission were investigated at Kuopio University Hospital.METHODS: Forty untreated and 52 coeliac patients in remission were admitted to the study. The control group included 77 persons. Four-day food re... | ['Adult', 'Aged', 'Anthropometry', 'Blood Chemical Analysis', 'Celiac Disease', 'Chi-Square Distribution', 'Diet', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nutritional Status', 'Prognosis'] | 7,569,766 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E01.370.225.124.100', 'E05.200.124.100'], ['C06.405.469.637.250', 'C18.452.603.250'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['G07.203.650.240'], ['B01.050.150.900.649.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
PD-PK evaluation of freeze-dried atorvastatin calcium-loaded poly-å-caprolactone nanoparticles. | In this work lyophilized poly-å-caprolactone nanoparticles (NPs) loaded with atorvastatin calcium (AC) were developed in an attempt to improve the in-vivo performance of AC following oral administration. The individual and combined effects of several formulation variables were previously investigated using step-wise fu... | ['Administration, Oral', 'Animals', 'Anticholesteremic Agents', 'Atorvastatin', 'Cholesterol', 'Delayed-Action Preparations', 'Drug Liberation', 'Freeze Drying', 'Male', 'Nanoparticles', 'Particle Size', 'Polyesters', 'Rats', 'Triglycerides'] | 27,021,467 | [['E02.319.267.100'], ['B01.050'], ['D27.505.519.186.071.202', 'D27.505.954.557.500.202'], ['D03.383.129.578.075', 'D10.251.450.200'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D26.255.210', 'E02.319.300.253'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['E01.370.225.500.620.760.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Stereological measures of trabecular bone structure: comparison of 3D micro computed tomography with 2D histological sections in human proximal tibial bone biopsies. | Stereology applied on histological sections is the 'gold standard' for obtaining quantitative information on cancellous bone structure. Recent advances in micro computed tomography (microCT) have made it possible to acquire three-dimensional (3D) data non-destructively. However, before the 3D methods can be used as a s... | ['Aged', 'Aged, 80 and over', 'Anatomy, Cross-Sectional', 'Biopsy', 'Bone Density', 'Bone and Bones', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Male', 'Microscopy', 'Middle Aged', 'Tibia', 'Tomography, X-Ray Computed'] | 15,857,378 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['H01.158.100.185'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['G11.427.100'], ['A02.835.232', 'A10.165.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.3... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Low-light image enhancement of high-speed endoscopic videos using a convolutional neural network. | Laryngeal endoscopy is one of the primary diagnostic tools for laryngeal disorders. The main techniques are videostroboscopy and lately high-speed video endoscopy. Unfortunately, due to the restricting anatomy of the larynx and technical limitations of the recording equipment, many videos suffer from insufficient illum... | ['Deep Learning', 'Humans', 'Image Enhancement', 'Laryngoscopy', 'Neural Networks, Computer', 'Reproducibility of Results', 'Video Recording'] | 30,900,057 | [['G17.035.250.500.250', 'G17.485.500', 'L01.224.050.375.530.250', 'L01.224.050.375.605.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.386.460', 'E01.370.388.250.525', 'E04.502.250.525', 'E04.580.373'], ['G17.485', 'L01.224.050.375.605'], ['E05.318.370.725'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Batroxase, a new metalloproteinase from B. atrox snake venom with strong fibrinolytic activity. | The structures and functional activities of metalloproteinases from snake venoms have been widely studied because of the importance of these molecules in envenomation. Batroxase, which is a metalloproteinase isolated from Bothrops atrox (Par?) snake venom, was obtained by gel filtration and anion exchange chromatograph... | ['Amino Acid Sequence', 'Animals', 'Bothrops', 'Crotalid Venoms', 'Fibrinolysis', 'Isoelectric Point', 'Mass Spectrometry', 'Metalloproteases', 'Models, Molecular', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid'] | 22,483,847 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.833.672.125.937.240.375'], ['D20.888.850.960.200', 'D23.946.833.850.960.200'], ['G09.188.390.150.390'], ['E05.301.300.663.500', 'G02.300.500'], ['E05.196.566'], ['D08.811.277.656.675'], ['E05.599.595'], ['L01.453.245.667'], ['G02.111.810.200', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[High-dose carboplatin superselective intraarterial chemotherapy in advanced head and neck cancer]. | Advances in vascular radiology techniques for superselective transfemoral arterial infusion prompted us to evaluate the effects of high-dose rapid regional carboplatin infusion for patients with advanced head and neck squamous cell carcinomas. Twenty untreated patients received three infusions of carboplatin (300-350 m... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Carboplatin', 'Chemotherapy, Adjuvant', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Injections, Intravenous', 'Male', 'Middle Aged', 'Mouth', 'Mouth Neoplasms', 'Nasopharyngeal Neoplasms', 'Nasopharynx', 'Oropharyngeal Neoplasms', 'Oropharynx', 'Retrospective Stu... | 8,984,837 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['D02.257.125'], ['E02.186.170', 'E02.319.170'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['M01.060.116.630'], ['A01.456.505.631', 'A03.556.500', 'A14.549'], ['C04.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Vulvodynia - Diagnostics and Management Strategies]. | Vulvodynia - Diagnostics and Management Strategies Abstract. Vulvodynia is characterized by chronic, idiopathic vulvar pain lasting for at least three months. After exclusion of other, specific diseases associated with vulvar pain, which can be treated accordingly, realistic therapy goals for this chronic disease shoul... | ['Female', 'Humans', 'Transcutaneous Electric Nerve Stimulation', 'Vulvodynia'] | 31,387,503 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.331.800', 'E02.779.468.800', 'E02.831.535.468.800', 'E03.091.823'], ['C13.351.500.944.951']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects and moderators of exercise on muscle strength, muscle function and aerobic fitness in patients with cancer: a meta-analysis of individual patient data. | OBJECTIVE: To optimally target exercise interventions for patients with cancer, it is important to identify which patients benefit from which interventions.DESIGN: We conducted an individual patient data meta-analysis to investigate demographic, clinical, intervention-related and exercise-related moderators of exercise... | ['Exercise Therapy', 'Humans', 'Muscle Strength', 'Muscular Diseases', 'Neoplasms', 'Physical Fitness', 'Quality of Life'] | 30,181,323 | [['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.600.425', 'G11.427.560'], ['C05.651', 'C10.668.491'], ['C04'], ['G11.427.685', 'I03.450.642.845.054.800', 'N01.400.545'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
[A case of squamous cell lung cancer in a nonsmoking female, successfully treated with docetaxel and cisplatin]. | A 62-year-old nonsmoking female was admitted to our hospital in May, 1998 complaining of marked cough accompanied by repeated hemosputa. Chest X-ray and CT examinations revealed a large tumor, located adjacent to a cystic lesion in the left lower lung field, in association with a clearly recognizable swelling of the ip... | ['Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Squamous Cell', 'Cisplatin', 'Docetaxel', 'Drug Administration Schedule', 'Female', 'Humans', 'Lung Neoplasms', 'Middle Aged', 'Paclitaxel', 'Smoking', 'Taxoids'] | 10,660,748 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.426.392.368.242.888.389', 'D02.455.849.291.850.389'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.54... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer. | The trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) spike is a molecular machine that mediates virus entry into host cells and is the sole target for virus-neutralizing antibodies. The mature Env spike results from cleavage of a trimeric glycoprotein precursor, gp160, into three gp120 a... | ['Cell Line', 'Cryoelectron Microscopy', 'HIV Envelope Protein gp120', 'HIV Envelope Protein gp160', 'HIV Envelope Protein gp41', 'HIV Infections', 'HIV-1', 'Humans', 'Models, Molecular', 'Protein Conformation', 'Protein Multimerization', 'Protein Structure, Tertiary', 'Protein Subunits'] | 22,864,288 | [['A11.251.210'], ['E01.370.350.515.402.150', 'E05.595.402.150'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23.050.327.520.350'], ['D12.776.964.775.325.164.374', 'D12.776.964.775.562.500.750', 'D12.776.964.970.880.325.164.374'], ['D12.776.543.512.500.330', 'D12.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors affecting anterior knee pain following anatomic double-bundle anterior cruciate ligament reconstruction. | PURPOSE: The purpose of this study was to evaluate the prevalence of anterior knee pain in anatomic double-bundle anterior cruciate ligament (ACL) reconstruction and to identify critical factors affecting postoperative anterior knee pain development.METHODS: Subjects comprised 171 patients (171 knees) who underwent ana... | ['Adolescent', 'Adult', 'Anterior Cruciate Ligament', 'Anterior Cruciate Ligament Reconstruction', 'Arthralgia', 'Arthroscopy', 'Female', 'Humans', 'Knee Joint', 'Logistic Models', 'Male', 'Middle Aged', 'Pain, Postoperative', 'Prevalence', 'Risk Factors', 'Young Adult'] | 22,057,356 | [['M01.060.057'], ['M01.060.116'], ['A02.513.514.100', 'A02.835.583.512.100', 'A10.165.669.514.100'], ['E04.555.110.026', 'E04.680.101.026'], ['C05.550.091', 'C23.888.592.612.094', 'F02.830.816.444.350', 'G11.561.790.444.350'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of intravenous iloprost on pulmonary artery hypertension after paediatric congenital heart surgery. | OBJECTIVES: To investigate the effects of intravenous iloprost on pulmonary artery hypertension (PAH) in infants undergoing congenital heart surgery.METHODS: In this prospective, randomized study, the study group (n = 15) received a continuous infusion of iloprost (2.0 ng/kg/min) that was delivered immediately after we... | ['Cardiac Surgical Procedures', 'Dose-Response Relationship, Drug', 'Female', 'Heart Defects, Congenital', 'Humans', 'Hypertension, Pulmonary', 'Iloprost', 'Infant', 'Infusions, Intravenous', 'Male', 'Postoperative Care', 'Prospective Studies', 'Pulmonary Wedge Pressure', 'Treatment Outcome', 'Vasodilator Agents'] | 26,604,214 | [['E04.100.376', 'E04.928.220'], ['G07.690.773.875', 'G07.690.936.500'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.907.489.556'], ['D10.251.355.255.550.775.125', 'D23.469.050.175.725.775.125', 'D23.469.700.275'], ['M01.060.703'], ['E02.319.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential expression of voltage-sensitive K+ and Ca2+ currents in neurons of the honeybee olfactory pathway. | In order to understand the neuronal processes underlying olfactory learning, biophysical properties such as ion channel activity need to be analysed within neurons of the olfactory pathway. This study analyses voltage-sensitive ionic currents of cultured antennal lobe projection neurons and mushroom body Kenyon cells i... | ['Animals', 'Bees', 'Calcium', 'Calcium Channels', 'In Vitro Techniques', 'Ion Transport', 'Membrane Potentials', 'Olfactory Pathways', 'Olfactory Receptor Neurons', 'Potassium', 'Potassium Channels'] | 12,456,702 | [['B01.050'], ['B01.050.500.131.617.720.500.500.875.387'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['E05.481'], ['G03.143.500'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A08.186.211.180.699', 'A08.612.22... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Impact of Maturity Stage on Cell Membrane Integrity and Enzymatic Browning Reactions in High Pressure Processed Peaches (Prunus persica). | Fruit maturity is an important factor associated with final product quality, and it may have an effect on the level of browning in peaches that are high pressure processed (HPP). Peaches from three different maturities, as determined by firmness (M1 = 50-55 N, M2 = 35-40 N, and M3 = 15-20 N), were subjected to pressure... | ['Catechol Oxidase', 'Cell Membrane', 'Food Handling', 'Food Preservation', 'Fruit', 'Magnetic Resonance Spectroscopy', 'Maillard Reaction', 'Phenols', 'Plant Proteins', 'Pressure', 'Prunus persica'] | 27,556,337 | [['D08.811.682.690.708.125'], ['A11.284.149'], ['J01.576.423.200'], ['J01.576.423.850.700'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['E05.196.867.519'], ['G02.607.522'], ['D02.455.426.559.389.657'], ['D12.776.765'], ['G01.374.715'], ['B01.650.940.800.575.912.250.859.937.500.625.750']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
What induces pocket openings on protein surface patches involved in protein-protein interactions? | We previously showed for the proteins BCL-X(L), IL-2, and MDM2 that transient pockets at their protein-protein binding interfaces can be identified by applying the PASS algorithm to molecular dynamics (MD) snapshots. We now investigated which aspects of the natural conformational dynamics of proteins induce the formati... | ['Algorithms', 'Binding Sites', 'Computer Simulation', 'Interleukin-2', 'Models, Theoretical', 'Protein Binding', 'Proto-Oncogene Proteins c-mdm2', 'bcl-X Protein'] | 18,777,159 | [['G17.035', 'L01.224.050'], ['G02.111.570.120'], ['L01.224.160'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['E05.599'], ['G02.111.679', 'G03.808'], ['D08.811.464.938.750.562', 'D12.776.624.664.700.185', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of drinking water and total sodium intake on blood pressure. | A cohort of 295 persons from a rural area of Michigan were studied to determine if a relationship exists between high levels of sodium in drinking water and blood pressure. Sodium in drinking water, dietary sodium intake, blood pressure, sodium excretion, height, and weight were measured. No significant relationships b... | ['Adolescent', 'Adult', 'Age Factors', 'Blood Pressure', 'Child', 'Diastole', 'Diet', 'Female', 'Humans', 'Hypertension', 'Male', 'Michigan', 'Middle Aged', 'Sodium', 'Systole', 'Water Softening', 'Water Supply'] | 7,081,127 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.600.875.249', 'G09.330.380.076'], ['M01.060.406'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['G07.203.650.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['Z01.107.567.875.350.500', 'Z... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Azidotyrosylcalmodulin derivatives. Specific probes for protein-binding domains. | Azidocalmodulin has been shown to be a useful probe for calmodulin-binding proteins in a variety of systems (Andreasen, T. J., Keller, C. H. LaPorte, D. C., Edelman, A. M., and Storm, D. R. (1981) Proc. Natl. Acad. Sci. U. S. A. 78, 2782-2785). In previous work, this calmodulin derivative was generated by the modificat... | ['Amino Acids', 'Animals', 'Azides', 'Brain', 'Calmodulin', 'Calmodulin-Binding Proteins', 'Cattle', 'Enzyme Activation', 'Indicators and Reagents', 'Phosphoprotein Phosphatases', 'Phosphoric Diester Hydrolases', 'Photolysis', 'Protein Binding', 'Structure-Activity Relationship'] | 6,096,370 | [['D12.125'], ['B01.050'], ['D01.625.100', 'D02.159'], ['A08.186.211'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D12.776.157.142'], ['B01.050.150.900.649.313.500.380.271'], ['G02.111.263', 'G03.328'], ['D27.720.470.410'], ['D08.811.277.352.650.625'], ['D08.811.277.352.640'], ['G02.74... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Therapeutic hypothermia influences cell genesis and survival in the rat hippocampus following global ischemia. | Delayed hypothermia salvages CA1 neurons from global ischemic injury. However, the effects of this potent neuroprotectant on endogenous repair mechanisms, such as neurogenesis, have not been clearly examined. In this study, we quantified and phenotyped newly generated cells within the hippocampus following untreated an... | ['Animals', 'Brain Ischemia', 'CA1 Region, Hippocampal', 'Cell Survival', 'Hippocampus', 'Hypothermia, Induced', 'Neurogenesis', 'Neurons', 'Rats', 'Time Factors'] | 21,364,603 | [['B01.050'], ['C10.228.140.300.150', 'C14.907.253.092'], ['A08.186.211.180.405.099', 'A08.186.211.200.885.287.500.345.099'], ['G04.346'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E02.258.750'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G11.561.620'], ['A08.675', 'A11.6... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of antibodies to recombinant antigens from Lucilia cuprina following cutaneous immunisation of sheep. | Immunological control of cutaneous myiasis of sheep caused by Lucilia cuprina larvae has been an elusive goal. Antibody to antigens derived from the peritrophic membrane can stunt or kill larvae in a dose dependent fashion. Thus efficacy of vaccines employing these antigens may be limited by the amount of antibody in s... | ['Animals', 'Antibody Formation', 'Antigens', 'Diptera', 'Female', 'Immunization', 'Insect Proteins', 'Myiasis', 'Recombinant Proteins', 'Sheep', 'Sheep Diseases', 'Skin'] | 11,836,035 | [['B01.050'], ['G12.450.050.370.250'], ['D23.050'], ['B01.050.500.131.617.720.500.500.750'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['D12.776.093.500'], ['C01.610.858.211.503'], ['D12.776.828'], ['B01.050.150.900.649.313.500.380.791'], ['C22.836'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Trajectory Space: A Dual Representation for Nonrigid Structure from Motion. | Existing approaches to nonrigid structure from motion assume that the instantaneous 3D shape of a deforming object is a linear combination of basis shapes. These bases are object dependent and therefore have to be estimated anew for each video sequence. In contrast, we propose a dual approach to describe the evolving 3... | ['Algorithms', 'Computer Simulation', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Imaging, Three-Dimensional', 'Models, Biological', 'Movement', 'Pattern Recognition, Automated', 'Photography', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Signal Processing, Computer-Assis... | 21,079,275 | [['G17.035', 'L01.224.050'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.400', 'L01.224.308.410'], ['E05.599.395'], ['G07.568', 'G11.427.410'], ['L01.399.750'], ['E01.370.35... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Ten questions on venous thromboembolism]. | Venous thromboembolism (VTE), which includes pulmonary embolism and deep vein thrombosis, is a leading cause of morbidity and mortality worldwide. Based on new evidence, the management and treatment of VTE have changed over the years. For several decades, low molecular weight heparin and vitamin K antagonists have been... | ['Anticoagulants', 'Humans', 'Pulmonary Embolism', 'Venous Thromboembolism', 'Venous Thrombosis', 'Vitamin K'] | 31,697,267 | [['D27.505.954.502.119'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.746', 'C14.907.355.350.700'], ['C14.907.355.590.700'], ['C14.907.355.830.925'], ['D02.455.426.559.847.638.721.374', 'D02.455.849.291.523.500', 'D04.615.638.721.374']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species. | Listeria adhesion protein (LAP), an alcohol acetaldehyde dehydrogenase (lmo1634), interacts with host-cell receptor Hsp60 to promote bacterial adhesion during the intestinal phase of Listeria monocytogenes infection. The LAP homologue is present in pathogens (L. monocytogenes, L. ivanovii) and non-pathogens (L. innocua... | ['Adhesins, Bacterial', 'Alcohol Dehydrogenase', 'Aldehyde Oxidoreductases', 'Bacterial Adhesion', 'Caco-2 Cells', 'Enterocytes', 'Humans', 'Listeria', 'Listeria monocytogenes', 'Listeriosis'] | 20,507,888 | [['D12.776.097.120.050', 'D12.776.543.100.050', 'D23.050.161.050'], ['D08.811.682.047.820.250'], ['D08.811.682.657.163'], ['G06.099.050'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A Bilateral Comparison of the Underlying Mechanics Contributing to the Seated Single-Arm Shot-Put Functional Performance Test. | CONTEXT: Functional performance tests (FPTs) are tools used to assess dynamic muscle strength and power. In contrast to the lower extremity, fewer FPTs are available for the upper extremity. The seated single-arm shot put test has the potential to fill the void in upper extremity FPTs; however, the underlying mechanics... | ['Adult', 'Biomechanical Phenomena', 'Cross-Over Studies', 'Exercise Test', 'Female', 'Humans', 'Male', 'Muscle Strength', 'Physical Functional Performance', 'Upper Extremity', 'Young Adult'] | 30,299,159 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.600.425', 'G11.427.560'], ['N01.400.545.750'], ['A01.378.800'], ['M01.060.116.815... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Outpatient termination of pregnancy: halothane or alfentanil-supplemented anaesthesia. | Inhalation anaesthesia with halothane was compared with i.v. alfentanil in 66 unpremedicated patients undergoing suction termination of pregnancy as outpatients. Blood loss was significantly greater in the halothane group with a mean loss of 213 ml, compared with a mean loss of 89.8 ml in the alfentanil group. There wa... | ['Abortion, Induced', 'Adjuvants, Anesthesia', 'Adolescent', 'Adult', 'Alfentanil', 'Ambulatory Surgical Procedures', 'Anesthesia Recovery Period', 'Anesthesia, General', 'Anesthesia, Obstetrical', 'Female', 'Fentanyl', 'Halothane', 'Hemorrhage', 'Humans', 'Intraoperative Complications', 'Intraoperative Period', 'Pregn... | 3,936,528 | [['E04.520.050'], ['D27.505.954.427.010'], ['M01.060.057'], ['M01.060.116'], ['D03.383.621.265.100'], ['E04.030'], ['E03.160', 'E04.614.750.055', 'N02.421.585.753.750.055'], ['E03.155.197'], ['E03.155.364'], ['D03.383.621.265'], ['D02.455.526.340'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lignans-rich extract from Herpetospermum caudigerum alleviate physical fatigue in mice. | OBJECTIVE: To ascertain anti-fatigue constituents and mechanisms of Herpetospermum caudigerum.METHODS: The 80% ethanol extracts of Herpetospermum caudigerum were partitioned with chloroform, ethyl acetate and n-butanol, respectively. Male Kunming mice were divided into 13 groups with 16 mice in each group: a control gr... | ['Animals', 'Body Weight', 'Cucurbitaceae', 'Fatigue', 'Glycogen', 'Lignans', 'Liver', 'Male', 'Mice', 'Plant Extracts', 'Swimming', 'Time Factors'] | 27,783,320 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B01.650.940.800.575.912.250.300'], ['C23.888.369'], ['D05.750.078.562.388', 'D09.698.365.388'], ['D02.455.426.559.389.140.450'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Performance status 1 predicts psychological response in female, but not male, ambulatory cancer patients. | This study aimed to identify gender differences in the impact of performance status (PS) 1, that is, of physically mild impairment, on psychological distress and coping in ambulatory cancer patients. The subjects were 260 male and 242 female cancer outpatients who participated in a structured interview and completed th... | ['Activities of Daily Living', 'Adaptation, Psychological', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasms', 'Psychiatric Status Rating Scales', 'Sex Factors'] | 12,690,547 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['F01.058'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['M01.060.116.630... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
An immersed boundary lattice Boltzmann approach to simulate deformable liquid capsules and its application to microscopic blood flows. | In this paper, we develop an immersed boundary lattice Boltzmann approach to simulate deformable capsules in flows. The lattice Boltzmann method is utilized to solve the incompressible flow field over a regular Eulerian grid, while the immersed boundary method is employed to incorporate the fluid-membrane interaction w... | ['Algorithms', 'Biophysics', 'Computer Graphics', 'Computer Simulation', 'Membranes', 'Microfluidics', 'Models, Statistical', 'Numerical Analysis, Computer-Assisted', 'Pressure', 'Rheology', 'Software', 'Viscosity'] | 18,185,006 | [['G17.035', 'L01.224.050'], ['H01.158.344', 'H01.671.100'], ['L01.224.108', 'L01.296.110'], ['L01.224.160'], ['A10.615'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['L01.224.680.700'], ['G01.374.715'], ['E05.830', 'H01.6... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Vitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme. | Vitamin D and its analogs have been shown to display anti-proliferative effects in a wide variety of cancer types including glioblastoma multiforme (GBM). These anticancer effects are mediated by its active metabolite, 1á, 25-dihydroxyvitamin D3 (calcitriol) acting mainly through vitamin D receptor (VDR) signaling. In ... | ['Adult', 'Age Factors', 'Brain Neoplasms', 'Calcitriol', 'Calcium Channel Agonists', 'Cell Line, Tumor', 'Cell Movement', 'Cell Survival', 'Cyclin D1', 'Female', 'Gene Expression Regulation, Neoplastic', 'Glioblastoma', 'Humans', 'Male', 'Middle Aged', 'Oncogene Proteins', 'RNA, Small Interfering', 'Receptors, Calcitr... | 24,584,679 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570.938.146.478.387.300'], ['D27.505.519.562.124', 'D27.505.696.260.250', 'D... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The development of grooming in the ontogeny of rats and mice]. | Experiments have been made on rats and mice within the first month of postnatal life. Common age dynamics of grooming reactions for these animals was shown which consists of a sharp intensification of grooming movements at the 3rd week, i.e. at the period of "behavioral arousal", as well as of heterochronous onset of d... | ['Aging', 'Animals', 'Ecology', 'Grooming', 'Mice', 'Periodicity', 'Rats', 'Time Factors'] | 7,831,974 | [['G07.345.124'], ['B01.050'], ['H01.158.273.248', 'H01.277.249'], ['F01.145.113.111.453'], ['B01.050.150.900.649.313.992.635.505.500'], ['G01.910.645', 'G07.180.562'], ['B01.050.150.900.649.313.992.635.505.700'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Optical magnetometer array for fetal magnetocardiography. | We describe an array of spin-exchange-relaxation-free optical magnetometers designed for detection of fetal magnetocardiography (fMCG). The individual magnetometers are configured with a small volume with intense optical pumping, surrounded by a large pump-free region. Spin-polarized atoms that diffuse out of the optic... | ['Feedback', 'Fetus', 'Magnetic Phenomena', 'Magnetocardiography', 'Optical Phenomena'] | 22,739,870 | [['L01.906.394.211'], ['A16.378'], ['G01.358'], ['E01.370.370.380.487', 'E01.370.405.435', 'E05.540.249'], ['G01.590']] | ['Information Science [L]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The RNA polymerase II preinitiation complex formed in the presence of ATP. | ATP hydrolysis is required for transcriptional initiation by RNA polymerase II in vitro. Reconstituted transcription using purified initiation factors and RNA polymerase II have revealed that the step dependent on ATP hydrolysis occurs at the same time as initiation of RNA synthesis. We report here that ATP hydrolysis ... | ['Adenosine Triphosphate', 'Adenylyl Imidodiphosphate', 'Centrifugation, Density Gradient', 'Deoxyadenine Nucleotides', 'Glycerol', 'HeLa Cells', 'Humans', 'Hydrolysis', 'RNA Polymerase II', 'Transcription, Genetic'] | 9,321,661 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D03.633.100.759.646.138.236.050', 'D13.695.667.138.236.050', 'D13.695.827.068.236.050'], ['E05.181.724.336', 'E05.196.941.336'], ['D03.633.100.759.646.138.410', 'D13.695.201.100', 'D13.695.667.138.410'], ['D02.033.800.875.500', 'D09.853.8... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment. | A new group of compounds, promising for the design of original multitarget therapeutic agents for treating neurodegenerative diseases, based on conjugates of aminoadamantane and carbazole derivatives was synthesized and investigated. Compounds of these series were found to interact with a group of targets that play an ... | ['Alzheimer Disease', 'Amantadine', 'Carbazoles', 'Carboxylesterase', 'Cholinesterase Inhibitors', 'Drug Design', 'Erythrocytes', 'Humans', 'Memantine', 'Microtubules', 'Molecular Docking Simulation', 'Protein Binding', 'Receptors, N-Methyl-D-Aspartate'] | 28,358,144 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D02.455.426.100.050.035'], ['D03.633.100.473.144', 'D03.633.300.148'], ['D08.811.277.352.100.100'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['A11.11... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Factors associated with the frequency of house calls by primary care physicians. | OBJECTIVE: To evaluate factors associated with the frequency of house calls by primary care physicians.DESIGN: A cross-sectional design with a self-administered mailed survey. SITTING/PARTICIPANTS: 751 primary care physicians who care for Medicaid patients in Virginia.RESULTS: Among 389 physician respondents (52%), reg... | ['Adult', 'Cross-Sectional Studies', 'Female', 'House Calls', 'Humans', 'Male', 'Middle Aged', 'Physicians, Family', 'Surveys and Questionnaires', 'Virginia'] | 1,890,505 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N04.452.758.307'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.485.810.770', 'N02.360.810.770'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['Z01.107.567.875.075... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Calcium-activated inward spike after-currents in bursting neurone R15 of Aplysia. | 1. Slow inward and outward after-currents follow action potentials in the bursting pacemaker neurone, R 15, of Aplysia californica. These experiments were performed to examine the role of axo-dendritic calcium influx in activating these after currents. 2. Depolarizing voltage-clamp commands issued at the soma were used... | ['Action Potentials', 'Animals', 'Aplysia', 'Barium', 'Calcium', 'Dopamine', 'Egtazic Acid', 'In Vitro Techniques', 'Ion Channels', 'Membrane Potentials', 'Neurons', 'Tetrodotoxin', 'Time Factors'] | 2,457,678 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['B01.050.500.644.400.060'], ['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D02.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Outcomes after craniotomy for resection of craniopharyngiomas in adults: analysis of the National Surgical Quality Improvement Program (NSQIP). | PURPOSE: Craniopharyngiomas occur in suprasellar locations that pose challenges for surgical management. This study evaluates the incidence of complications following craniotomy for craniopharyngioma in adults and investigates risk factors for these complications.METHODS: Patients who underwent craniotomy for excision ... | ['Adult', 'Aged', 'Craniopharyngioma', 'Craniotomy', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Patient Readmission', 'Pituitary Neoplasms', 'Postoperative Complications', 'Prognosis', 'Quality Improvement', 'Survival Rate', 'Time Factors'] | 31,228,138 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.465.625.200', 'C04.557.580.625.200'], ['E04.525.190'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.525'], ['E02.760.400.620', 'N02.421.585.400.620']... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORá. | Retinoid-related orphan receptor á (RORá) is a critical master transcription factor that governs postnatal cerebellar development. An RORá-deficient cerebellum has a persistent external granular layer (EGL), rudimentary Purkinje cell (PC) dendrites, grossly reduced numbers of immature parallel fiber (PF)-PC synapses, a... | ['Animals', 'Cerebellum', 'Dendrites', 'Excitatory Postsynaptic Potentials', 'Genetic Vectors', 'Humans', 'Lentivirus', 'Membrane Potentials', 'Mice', 'Mice, Inbred C57BL', 'Mice, Neurologic Mutants', 'Neuronal Plasticity', 'Nuclear Receptor Subfamily 1, Group F, Member 1', 'Purkinje Cells', 'Receptors, Metabotropic Gl... | 26,122,696 | [['B01.050'], ['A08.186.211.132.810.428.200'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.650.589'], ['G01.154.535', 'G04.5... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TGF-beta1-stimulated osteoblasts require intracellular calcium signaling for enhanced alpha5 integrin expression. | The osteoactive factor, transforming growth factor beta1 (TGF-beta1), influences osteoblast activity and bone function. We recently characterized a Smad-independent TGF-beta1-induced Ca(2+) signal in human osteoblasts (HOB) and demonstrated its importance in cell adhesion. Here, we further elucidate the role of the TGF... | ['Actins', 'Antigens, CD', 'Calcium', 'Calcium Channel Blockers', 'Cell Adhesion', 'Cells, Cultured', 'Cytoskeleton', 'Fibronectins', 'Humans', 'Immunoblotting', 'Immunohistochemistry', 'Integrin alpha5', 'Integrins', 'Nifedipine', 'Osteoblasts', 'Reverse Transcriptase Polymerase Chain Reaction', 'Signal Transduction',... | 12,081,894 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['G04.022'], ['A11.251'], ['A11.284.430.214.190.750'], ['D12.776.377.715.390',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Airway Hyperresponsiveness to Mannitol in Obesity Before and After Bariatric Surgery. | BACKGROUND: The relationship between airway hyperresponsiveness (AHR) and obesity, a low-grade systemic inflammatory condition, remains largely unknown. It is established that AHR to indirect stimuli is associated with active airway inflammation. The objectives were to investigate the rate of AHR to mannitol in obese s... | ['Adult', 'Bariatric Surgery', 'Bronchial Hyperreactivity', 'Bronchoconstrictor Agents', 'Female', 'Humans', 'Lung', 'Male', 'Mannitol', 'Middle Aged', 'Obesity, Morbid', 'Prospective Studies', 'Respiratory Function Tests', 'Spirometry'] | 25,618,781 | [['M01.060.116'], ['E02.650.500.062', 'E04.062'], ['C08.127.210'], ['D27.505.696.663.050.100', 'D27.505.954.796.170'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['D02.033.800.609', 'D09.853.609'], ['M01.060.116.630'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.69... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The acute antiarrhythmic effects of droxicainide and lidocaine in unanesthetized dogs. | Two groups of unanesthetized dogs, each consisting of six animals with ventricular tachycardia caused by two-stage ligation of the anterior descending branch of the left coronary artery on the day before treatment, were given continuous intravenous infusions of 0.5 mg/kg/min of either droxicainide [DL-N-(2-hydroxyethyl... | ['Anilides', 'Animals', 'Anti-Arrhythmia Agents', 'Arrhythmias, Cardiac', 'Dogs', 'Heart Rate', 'Lidocaine'] | 6,200,728 | [['D02.065.199', 'D02.092.146.113'], ['B01.050'], ['D27.505.954.411.097'], ['C14.280.067', 'C23.550.073'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D02.065.199.092.500', 'D02.092.146.113.092.500']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitative cerebral MR perfusion imaging: preliminary results in stroke. | PURPOSE: To evaluate quantitative cerebral blood flow (qCBF) with traditional time-based measurements or metrics of cerebral perfusion: time to peak (Tmax) and mean transit time (MTT) in stroke patients.MATERIALS AND METHODS: Nine ischemic stroke patients (four male, five female, 63 ± 16 years old) were included in the... | ['Adult', 'Aged', 'Aged, 80 and over', 'Area Under Curve', 'Brain', 'Brain Ischemia', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Perfusion Imaging', 'Stroke', 'Treatment Outcome'] | 20,882,609 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['A08.186.211'], ['C10.228.140.300.150', 'C14.907.253.092'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Participation of endogenous nitric oxide in the effect of hypoxia in vitro on neuro-effector transmission in guinea-pig ileum. | The implication of endogenous nitric oxide in the effect of hypoxia on the neurotransmission in the enteric nervous system of guinea-pig ileum was studied in vitro. Three methodological approaches have been used: (i) Stretch-induced phases of peristaltic reflex in ileal segments; (ii) twitch contractions of longitudina... | ['Acetylcholine', 'Animals', 'Cholinergic Fibers', 'Electric Stimulation', 'Enteric Nervous System', 'Enzyme Inhibitors', 'Female', 'Guinea Pigs', 'Hypoxia', 'Ileum', 'In Vitro Techniques', 'Male', 'Nitric Oxide', 'Nitroarginine', 'Peristalsis', 'Reflex', 'Synaptic Transmission', 'Tritium'] | 11,543,943 | [['D02.092.211.111'], ['B01.050'], ['A08.675.127.500', 'A08.675.542.234', 'A11.671.188.500', 'A11.671.501.234'], ['E05.723.402'], ['A08.800.050.150'], ['D27.505.519.389'], ['B01.050.150.900.649.313.992.550'], ['C23.888.852.079'], ['A03.556.124.684.249', 'A03.556.249.124'], ['E05.481'], ['D01.339.387', 'D01.625.550.500'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Light physical activity determined by a motion sensor decreases insulin resistance, improves lipid homeostasis and reduces visceral fat in high-risk subjects: PreDiabEx study RCT. | OBJECTIVE: To examine physical activity (PA) thresholds affecting glucose, insulin and lipid concentrations and body fat composition in high-risk patients for type 2 diabetes (T2D).INTERVENTION: A total of 113 subjects of both genders having abnormal glucose levels in the oral glucose tolerance test were contacted. A t... | ['Blood Glucose', 'Diabetes Mellitus, Type 2', 'Exercise Therapy', 'Female', 'Finland', 'Glucose Tolerance Test', 'Homeostasis', 'Humans', 'Insulin Resistance', 'Intra-Abdominal Fat', 'Lipid Metabolism', 'Male', 'Middle Aged', 'Obesity', 'Risk Reduction Behavior', 'Surveys and Questionnaires', 'Treatment Outcome', 'Wal... | 24,285,336 | [['D09.947.875.359.448.500'], ['C18.452.394.750.149', 'C19.246.300'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['Z01.542.816.186'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500', 'G07.690.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social ... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Annotating proteins by mining protein interaction networks. | MOTIVATION: In general, most accurate gene/protein annotations are provided by curators. Despite having lesser evidence strengths, it is inevitable to use computational methods for fast and a priori discovery of protein function annotations. This paper considers the problem of assigning Gene Ontology (GO) annotations t... | ['Amino Acid Sequence', 'Artificial Intelligence', 'Database Management Systems', 'Databases, Protein', 'Documentation', 'Information Storage and Retrieval', 'Molecular Sequence Data', 'Natural Language Processing', 'Pattern Recognition, Automated', 'Protein Interaction Mapping', 'Proteins', 'Sequence Alignment', 'Sequ... | 16,873,481 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G17.035.250', 'L01.224.050.375'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['L01.453.245'], ['L01.313.500.750.280', 'L01.470'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Inappropriate secretion of antidiuretic hormone: a rare complication after carotid endarterectomy. | The syndrome of inadequate secretion of the antidiuretic hormone (SIADH) is a very rare complication after carotid endarterectomy, characterized by hyponatremia, decrease of serum osmolarity as well as an increase in urinary osmolarity. We report the case of an 80-year-old woman who developed, 24 hours after the surger... | ['Aged, 80 and over', 'Endarterectomy, Carotid', 'Female', 'Humans', 'Hyponatremia', 'Inappropriate ADH Syndrome', 'Osmolar Concentration', 'Sodium', 'Urine'] | 16,861,016 | [['M01.060.116.100.080'], ['E04.100.814.456.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.950.620'], ['C10.228.140.617.738.320', 'C18.452.950.626', 'C19.700.490'], ['G02.640'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['A12.207.927']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Potent inhibition of human ovarian steroidogenesis by insulin-like growth factor binding protein-4 (IGFBP-4). | Several studies have now documented the existence of IGFBPs in follicular fluid and their correlation with the health of the follicle. In particular, increased levels of IGFBP-4 have been reported in androgen-dominant atretic follicles and those from polycystic ovaries. The aim of this study was to elucidate the role o... | ['Androstenedione', 'Cells, Cultured', 'Estradiol', 'Female', 'Follicle Stimulating Hormone', 'Granulosa Cells', 'Humans', 'Insulin-Like Growth Factor Binding Protein 4', 'Luteinizing Hormone', 'Theca Cells'] | 9,435,457 | [['D04.210.500.054.079.329', 'D04.210.500.578.502.112', 'D06.472.040.502.112', 'D06.472.334.851.968.875'], ['A11.251'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['A05.360.319.114.630.535.200', 'A06.300.312.497.535.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
First record of Indolestes cyaneus (Selys, 1862) from Vietnam and notes on its color variation (Odonata: Zygoptera: Lestidae). | First record of Indolestes cyaneus (Selys, 1862) from Vietnam with providing illustrations of its detailed structures, as well as notes on the coloration of the populations from Taiwan, Nepal and India. | ['Animals', 'India', 'Nepal', 'Odonata', 'Taiwan', 'Vietnam'] | 31,715,808 | [['B01.050'], ['Z01.252.245.393'], ['Z01.252.245.674'], ['B01.050.500.131.617.720.750.750'], ['Z01.252.474.872', 'Z01.639.850'], ['Z01.252.145.945']] | ['Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Dexamethasone stimulates placental system A transport and trophoblast differentiation in term villous explants. | Synthetic glucocorticoids (GCs) are given to women with threatened preterm labour but their administration has been linked to reduced infant birthweight. The underlying mechanisms are unknown, but impaired placental development and/or function has been implicated. The activity of the system A amino acid transporter is ... | ['11-beta-Hydroxysteroid Dehydrogenase Type 2', 'Amino Acid Transport System A', 'Cell Differentiation', 'Cell Proliferation', 'Cell Shape', 'Chorionic Gonadotropin', 'Dexamethasone', 'Dose-Response Relationship, Drug', 'Female', 'Gene Expression Regulation', 'Gene Products, env', 'Glucocorticoids', 'Humans', 'In Vitro... | 20,045,184 | [['D08.811.682.047.436.174.600', 'D08.811.682.047.820.100.600'], ['D12.776.157.530.200.500.100', 'D12.776.543.585.200.500.100'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.320'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D04.210.500.745.432.769.344', 'D0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Meshing human resources planning with strategic business planning: a model approach. | Many people are touting the need to take a strategic approach to human resources management--but this is more easily said than done, point out authors Lloyd Baird, associate professor of management at the School of Management and the Human Resources Policy Institute at Boston University; Ilan Meshoulam, personnel execu... | ['Models, Theoretical', 'Personnel Management', 'Planning Techniques'] | 10,299,270 | [['E05.599'], ['N04.452.677'], ['N04.452.718']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The design of a low literacy decision aid about rheumatoid arthritis medications developed in three languages for use during the clinical encounter. | BACKGROUND: Shared decision-making in rheumatoid arthritis (RA) care is a priority among policy makers, clinicians and patients both nationally and internationally. Demands on patients to have basic knowledge of RA, treatment options, and details of risk and benefit when making medication decisions with clinicians can ... | ['Adult', 'Arthritis, Rheumatoid', 'Decision Making', 'Decision Support Techniques', 'Health Literacy', 'Humans'] | 25,649,726 | [['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['F02.463.785.373'], ['E05.245', 'L01.313.500.750.190'], ['I02.233.332.186.500', 'L01.143.450.500', 'N02.421.726.407.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Development of a matrix solid-phase dispersion extraction combined with high-performance liquid chromatography for determination of five lignans from the Schisandra chinensis. | A method based on a simplified sample extraction by matrix solid phase dispersion (MSPD) followed by HPLC determination is validated for analysis of five lignans in Schisandra chinensis. The MSPD parameters that affect the extraction efficiency of lignans from S. chinensis were examined and optimized. The optimal extra... | ['Chromatography, High Pressure Liquid', 'Lignans', 'Limit of Detection', 'Linear Models', 'Plant Extracts', 'Reproducibility of Results', 'Schisandra', 'Solid Phase Extraction'] | 26,773,892 | [['E05.196.181.400.300'], ['D02.455.426.559.389.140.450'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['D20.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of genistein on the periovulatory expression of messenger ribonucleic acid for matrix metalloproteinases and tissue inhibitors of metalloproteinases in the rat ovary. | The matrix metalloproteinases (MMPs) play critical roles in the ovulatory process. Their expression and activity, together with those of the endogenous tissue inhibitors of metalloproteinases (TIMPs), are stimulated by LH. The LH surge initiates a cascade of events resulting in ovulation and formation of the corpus lut... | ['Animals', 'Collagenases', 'Enzyme Inhibitors', 'Female', 'Genistein', 'In Vitro Techniques', 'Luteinizing Hormone', 'Matrix Metalloproteinase 13', 'Matrix Metalloproteinase Inhibitors', 'Matrix Metalloproteinases', 'Ovary', 'Ovulation', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Tissue Inhibitor of Metallopro... | 11,226,050 | [['B01.050'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['D27.505.519.389'], ['D03.383.663.283.266.450.400.375', 'D03.633.100.150.266.450.400.375'], ['E05.481'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463'], ['D08.811.277.656.300.480.205.363', 'D08.811.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ovarian serous tumors of low malignant potential with nodal low-grade serous carcinoma. | Serous tumor of low malignant potential (SLMP) and low-grade serous carcinoma (LGSC) are part of one biological continuum, whereby SLMP can transform into LGSC. It has been suggested that some nodal SLMPs arise from nodal endosalpingiosis and evolve independently in lymph nodes (rather than being related to the ovarian... | ['Adult', 'Aged', 'Biomarkers, Tumor', 'Carcinoma', 'Disease-Free Survival', 'Female', 'Humans', 'Immunohistochemistry', 'Lymph Nodes', 'Lymphatic Metastasis', 'Middle Aged', 'Mitotic Index', 'Neoplasm Grading', 'Neoplasm Invasiveness', 'Neoplasm Recurrence, Local', 'Neoplasms, Cystic, Mucinous, and Serous', 'Ovarian N... | 22,613,998 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['C04.557.470.200'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers. | In mammals, one of the Mad homologues, Smad2, was reported to be a mediator of TGF-beta signaling, and was found mutated in some cases of colon and lung cancers. To extend the analysis of this gene, we previously investigated the genomic organization of the human Smad2 gene and defined the structure of 12 exons and fla... | ['Base Sequence', 'Colonic Neoplasms', 'DNA', 'DNA Primers', 'DNA-Binding Proteins', 'Humans', 'Introns', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Polymorphism, Single-Stranded Conformational', 'Smad2 Protein', 'Trans-Activators', 'Tumor Cells, Cultured'] | 9,635,866 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D13.444.308'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D12.776.260'], ['B01.050.150.900.649.313... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Association between Snoring and Leukocyte Telomere Length. | STUDY OBJECTIVES: Data on the association between snoring and telomere length, an indicator of biological aging, are very limited. Moreover, no polysomnography (PSG) studies on this association in a general population have been conducted. Our study aimed to evaluate the association between snoring and leukocyte telomer... | ['Adult', 'Aged', 'Aging', 'Cross-Sectional Studies', 'Female', 'Humans', 'Leukocytes', 'Male', 'Middle Aged', 'Polysomnography', 'Republic of Korea', 'Risk Factors', 'Sleep', 'Sleep Apnea Syndromes', 'Snoring', 'Surveys and Questionnaires', 'Telomere', 'Telomere Homeostasis'] | 26,715,224 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['M01.060.116.630'], ['E01.370.520.625'], ['Z01.252.474.557.750'], ['E05.318.740.600.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Differences in Language Ability and Emotional-Behavioral Problems according to Symptom Severity in Children with Autism Spectrum Disorder. | PURPOSE: The aim of this study was to investigate differences in language ability and emotional-behavioral problems according to the severity of social communication impairments (SCI) and restricted and repetitive behaviors (RRB) in children with autism spectrum disorders (ASD).MATERIALS AND METHODS: We grouped 113 chi... | ['Affective Symptoms', 'Autism Spectrum Disorder', 'Child', 'Child Behavior Disorders', 'Child, Preschool', 'Emotions', 'Female', 'Humans', 'Language', 'Language Development', 'Language Development Disorders', 'Male', 'Problem Behavior', 'Severity of Illness Index'] | 32,975,063 | [['F01.145.126.100'], ['F03.625.164.113'], ['M01.060.406'], ['F03.625.141'], ['M01.060.406.448'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F01.525.200.310'], ['C10.597.606.150.500.550', 'C23.888.592.604.150.500.550'], ['F01.145.126.972', 'F01.145.179.750'], ['E05.3... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Double-sector Lorenz plot scattering in an R-R interval analysis of patients with chronic atrial fibrillation: incidence and characteristics of vertices of the double-sector scattering. | Animal experiments have demonstrated that the minimum R-R interval during atrial fibrillation is proportional to the functional refractory period of the atrioventricular node. On Lorenz plots, atrial fibrillation is characterized by sector-shaped scattering; the vertex of the sector (ie, the minimum R-R interval) repre... | ['Aged', 'Aged, 80 and over', 'Atrial Fibrillation', 'Chronic Disease', 'Circadian Rhythm', 'Electrocardiography, Ambulatory', 'Electrophysiology', 'Female', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Observer Variation', 'Signal Processing, Computer-Assisted'] | 9,682,899 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.067.198', 'C23.550.073.198'], ['C23.550.291.500'], ['G07.180.562.190'], ['E01.370.370.380.240.230', 'E01.370.405.240.230', 'E01.370.520.500.230'], ['H01.158.344.528', 'H01.158.782.236'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.40... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
A genetics-led approach defines the drug target landscape of 30 immune-related traits. | Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of efficacy on early target selection1. Drug targets with genetic support are more likely to be therapeutically valid2,3, but the translational use of genome-scale data such as from genome-wide association studies for drug t... | ['Arthritis, Rheumatoid', 'Drug Discovery', 'Gene Expression Regulation', 'Gene Regulatory Networks', 'Genome, Human', 'Genome-Wide Association Study', 'Humans', 'Immunity, Innate', 'Polymorphism, Single Nucleotide', 'Quantitative Trait Loci', 'Selection, Genetic'] | 31,253,980 | [['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['G05.308'], ['G05.360.080.689.360'], ['G05.360.340.350'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Clinical diagnosis and surgical management of 110 cases of facial nerve schwannomas]. | Objective: To elucidate the clinical behavior, causes of misdiagnosis, surgical management, and outcomes of facial nerve schwannomas (FNS). Methods: A retrospective review in Chinese People's Liberation Army General Hospital from January 1, 2002 to December 31, 2015 was carried out and evaluated 110 patients with FNS, ... | ['Adolescent', 'Adult', 'Aged', 'Anastomosis, Surgical', 'Bell Palsy', 'Cranial Nerve Neoplasms', 'Diagnostic Errors', 'Facial Nerve', 'Facial Nerve Diseases', 'Facial Paralysis', 'Female', 'Humans', 'Hypoglossal Nerve', 'Male', 'Middle Aged', 'Neurilemmoma', 'Retrospective Studies', 'Treatment Outcome', 'Young Adult'] | 30,776,861 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E04.035'], ['C01.925.256.466.087', 'C07.465.094', 'C07.465.299.250', 'C10.292.319.250'], ['C04.588.614.300', 'C04.588.614.596.240', 'C10.292.225', 'C10.551.360', 'C10.551.775.250'], ['E01.354', 'N02.421.450.280'], ['A08.800.050.050.275', 'A08.800.050.600.149', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prognostic value of the extent of resection in supratentorial WHO grade II astrocytomas stratified for IDH1 mutation status: a single-center volumetric analysis. | Current evidence supports a maximized extent of resection (EOR) in low-grade gliomas (LGG), regardless of different histological subtypes and molecular markers. We therefore evaluated the prognostic impact of extensive, mainly intraoperative (i)MRI-guided surgery in low-grade astrocytomas stratified for IDH1 mutation s... | ['Adolescent', 'Adult', 'Astrocytoma', 'Cohort Studies', 'Female', 'Humans', 'Isocitrate Dehydrogenase', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Mutation', 'Prognosis', 'Statistics, Nonparametric', 'Supratentorial Neoplasms', 'Survival Analysis', 'Treatment Outcome', 'Young Adult'] | 27,344,556 | [['M01.060.057'], ['M01.060.116'], ['C04.557.465.625.600.380.080', 'C04.557.470.670.380.080', 'C04.557.580.625.600.380.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.820.475'], ['E01.370.350.825.500'], ['M01.060.11... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysis of veterinary drug residues in fish and shrimp composites collected during the Canadian Total Diet Study, 1993-2004. | Thirty shrimp, marine fish, freshwater fish, and canned fish composite samples collected and prepared as part of the Canadian Total Diet Study were analysed for 39 different veterinary drug residues. The analyses were undertaken to obtain baseline data that could be used to estimate the dietary exposure of Canadians to... | ['Animals', 'Aquaculture', 'Canada', 'Drug Residues', 'Fishes', 'Food Analysis', 'Food Contamination', 'Penaeidae', 'Seafood', 'Veterinary Drugs'] | 17,164,212 | [['B01.050'], ['J01.040.168'], ['Z01.107.567.176'], ['N06.850.460.200.250'], ['B01.050.150.900.493'], ['E05.362', 'J01.576.423.850.100'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['B01.050.500.131.365.190.660'], ['G07.203.300.600.875', 'J02.500.600.875'], ['D26.939']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
[Squamous cell carcinoma in the area of the parotid gland. Metastasis or primary tumor?]. | A total of 61 patients with a histological diagnosis of squamous cell carcinoma of the parotid gland were studied. The patients were classified into three categories. There were 34 patients with a metastasis to the parotid gland from a squamous cell carcinoma elsewhere within the head and neck who presented on average ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Diagnosis, Differential', 'Female', 'Humans', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Parotid Gland', 'Parotid Neoplasms'] | 2,228,743 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['A03.556.500.760.464', 'A10.336.779.464'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
To evaluate efficacy and safety of amphotericin B in two different doses in the treatment of post kala-azar dermal leishmaniasis (PKDL). | BACKGROUND: Post kala-azar dermal leishmaniasis (PKDL) is a skin disorder that usually occurs among patients with a past history of visceral leishmaniasis (VL). Cases are also reported without a history of VL. There is no satisfactory treatment regimen available at present. We aimed to compare the efficacy and safety o... | ['Adolescent', 'Adult', 'Amphotericin B', 'Antiprotozoal Agents', 'Child', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Leishmania', 'Leishmaniasis, Cutaneous', 'Leishmaniasis, Visceral', 'Male', 'Parasite Load', 'Renal Insufficiency', 'Treatment Outcome', 'Young Adult'] | 28,355,259 | [['M01.060.057'], ['M01.060.116'], ['D02.540.576.500.500'], ['D27.505.954.122.250.100'], ['M01.060.406'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.268.475.868.488'], ['C01.610.752.300.500.400', 'C01.610.858.560.400', 'C01.920.813.400', 'C17.800.838.775.560.400'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
"Two-in-one" fabrication of Fe3O4/MePEG-PLA composite nanocapsules as a potential ultrasonic/MRI dual contrast agent. | A new method for the fabrication of Fe(3)O(4) nanoparticles enveloped by polymeric nanocapsules is proposed. This method is characterized by combining a double emulsification with the interfacial coprecipitation of iron salts to form Fe(3)O(4)/polymer composite nanocapsules in a single step. To demonstrate the viabilit... | ['Contrast Media', 'Magnetic Resonance Imaging', 'Magnetite Nanoparticles', 'Nanocapsules', 'Particle Size', 'Polyesters', 'Polyethylene Glycols', 'Surface Properties', 'Ultrasonography'] | 21,863,846 | [['D27.505.259.500', 'D27.720.259'], ['E01.370.350.825.500'], ['J01.637.512.600.500.144.500'], ['D26.255.260.575', 'E02.319.300.380.575', 'J01.637.512.600.575'], ['G02.712'], ['D05.750.728', 'D25.720.728', 'J01.637.051.720.728'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J01.637.051.720.741'], ['G02.860'],... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of the synthetic NC-1059 peptide on diffusion of riboflavin across an intact corneal epithelium. | PURPOSE: To investigate the effect of the peptide NC-1059 on riboflavin (RF) diffusion across an intact corneal epithelium into the stroma.METHODS: NC-1059 peptide was synthesized by solid-phase synthesis with 9-fluorenylmethoxycarbonyl chemistry, characterized by reversed-phase HPLC, and matrix-assisted laser desorpti... | ['Animals', 'Cell Membrane Permeability', 'Chick Embryo', 'Chromatography, High Pressure Liquid', 'Corneal Stroma', 'Dose-Response Relationship, Drug', 'Epithelium, Corneal', 'Flavin Mononucleotide', 'Ion Channels', 'Ion Transport', 'Microscopy, Confocal', 'Models, Animal', 'Spectrometry, Mass, Matrix-Assisted Laser De... | 22,447,859 | [['B01.050'], ['G03.143.335', 'G04.175'], ['A13.350.150', 'A16.331.200'], ['E05.196.181.400.300'], ['A09.371.060.217.228'], ['G07.690.773.875', 'G07.690.936.500'], ['A09.371.060.217.325', 'A10.272.510'], ['D03.633.100.733.315.650.500', 'D03.633.300.507.650.500', 'D08.211.474.650.500', 'D13.695.827.349', 'D23.767.405.65... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A nationwide sampling of fast-food fried chicken: starch and moisture content. | A nationwide sampling plan was executed to estimate the nutrient composition of fast-food fried chicken in the United States. Ninety-four composite samples were selected from major chains in 10 cities. Starch contents were determined using a modified American Association of Cereal Chemists method. The amount of glucose... | ['Animals', 'Chickens', 'Cooking', 'Food Analysis', 'Starch', 'Water'] | 3,584,754 | [['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['J01.576.423.200.200'], ['E05.362', 'J01.576.423.850.100'], ['D05.750.078.562.855', 'D09.301.915', 'D09.698.365.855'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Antioxidant activity of Artemisia douglasiana besser extract and dehydroleucodine. | The charge (relative concentration) of antioxidants in aqueous extract and dehydroleucodine (DhL) from Artemisia douglasiana Besser was determined employing a procedure based on the quenching of luminol-enhanced chemiluminescence. Total reactive antioxidant potential (TRAP) and total antioxidant reactivity (TAR) values... | ['Anti-Ulcer Agents', 'Antioxidants', 'Artemisia', 'Humans', 'Lactones', 'Luminescent Measurements', 'Plant Extracts', 'Plants, Medicinal', 'Sesquiterpenes'] | 11,054,852 | [['D27.505.954.483.203'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B01.650.940.800.575.912.250.100.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.540'], ['E05.196.712.516'], ['D20.215.784.500', 'D26.667'], ['B01.650.560'], ['D02.455.849.765']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU. | OBJECTIVES: To determine whether newborn hearing screening in a well-baby nursery (WBN) and neonatal intensive care unit (NICU) nursery: 1) meet three targeted, screening, referral, and diagnostic follow-up rates; 2) compare the average age of diagnosis for infants admitted to the WIN and NICU; and 3) determine prevale... | ['Hearing', 'Humans', 'Infant, Newborn', 'Intensive Care Units, Neonatal', 'Neonatal Screening', 'Nurseries, Infant', 'Outpatients', 'Patient Discharge', 'Referral and Consultation'] | 27,023,324 | [['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N02.278.388.493.390.380'], ['E01.370.225.910', 'E01.370.500.580', 'E05.200.910', 'E05.318.308.980.438.580.580', 'N02.421.726.233.443.816', 'N05.715.360.300.800.438.500.575', 'N06.850.520.308.9... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Prehabilitation for adults diagnosed with cancer: A systematic review of long-term physical function, nutrition and patient-reported outcomes. | OBJECTIVE: Prehabilitation is increasingly being used to mitigate treatment-related complications and enhance recovery. An individual's state of health at diagnosis, including obesity, physical fitness and comorbidities, are influencing factors for the occurrence of adverse effects. This review explores whether prehabi... | ['Affect', 'Exercise Therapy', 'Gait', 'Humans', 'Neoplasms', 'Nutrition Therapy', 'Patient Reported Outcome Measures', 'Physical Fitness', 'Physical Functional Performance', 'Respiratory Function Tests'] | 30,859,650 | [['F01.470.047'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['E02.642'], ['E05.318.308.980.344.500', 'N03.349.380.210.750', 'N04.761.559.590.399.875', 'N05.425.210.500', 'N05.715.360.300.800.34... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Clinical technology assessment, cost-effective adoption, and quality management by hospitals in the 1990s. | Technology assessment in the 1990s must become an integral part of a hospital's strategic priority goals, with active participation of physicians and top management. Technology assessment should involve a wide range of criteria and health care consumer expectations, so that the appropriateness, effectiveness, cost-effe... | ['Academies and Institutes', 'Ambulatory Care', 'Cost-Benefit Analysis', 'Hospital Administration', 'Humans', 'Ohio', 'Outcome and Process Assessment, Health Care', 'Quality Control', 'Technology Assessment, Biomedical'] | 2,120,659 | [['N03.540.052'], ['E02.760.106', 'N02.421.585.106'], ['N03.219.151.125'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', 'Z01.107.567.875.510.540'], ['N04.761.559', 'N05.715.360.575'], ['J01.897.608'], ['N03.880... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
[The circumferential decompression by posterior transpedicular osteotomy and segmental instrumentation with interbody fusion for thoracic ossification of posterior iongitudinal ligament]. | OBJECTIVE: To observe the efficacy of the circumferential decompression with posterior transpedicular osteotomy and segmental instrumentation with interbody fusion for thoracic ossification of posterior Iongitudinal ligament (T-OPLL).METHODS: From May 2012 to June 2015, 16 consecutive patients underwent posterior trans... | ['Decompression, Surgical', 'Humans', 'Ligaments', 'Ossification of Posterior Longitudinal Ligament', 'Osteotomy', 'Pain', 'Physical Examination', 'Postoperative Period', 'Retrospective Studies', 'Thoracic Vertebrae', 'Treatment Outcome'] | 27,117,367 | [['E04.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.513', 'A10.165.669'], ['C05.116.900.480', 'C23.550.751.500'], ['E04.555.580'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['E01.370.600'], ['E04.614.750', 'N02.421.585.753.750'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Breakdown of the herbicide pyramin by micro-organisms of the soil (author's transl)]. | The herbicide Pyramin, which is employed in the cultivation of beets to combat broad-leaf weeds, contains the herbicidal substance 5-amino-4-chloro-2-phenyl-3 (2H) pyridazinone, abbreviated pyrazone. The breakdown of pyrazone in the soil was investigated and it was found that this substance disappears relatively quickl... | ['Bacteria', 'Biodegradation, Environmental', 'Chemical Phenomena', 'Chemistry', 'Herbicides', 'Pyridazines', 'Soil Microbiology', 'Temperature'] | 998,042 | [['B03'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['G02'], ['H01.181'], ['D27.720.031.700.366', 'D27.888.723.366'], ['D03.383.710'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Rat gastroduodenal motility in vivo: involvement of NO and ATP in spontaneous motor activity. | Our studies of fasted anesthetized rats have shown that all spontaneous relaxations of the antrum are nitric oxide (NO) dependent. Duodenal motility is patterned into propagating "grouped" motor activity interposed with "intergroup" periods of nonpropagating motor activity; in the duodenum, only intergroup relaxations ... | ['Adenosine Triphosphate', 'Animals', 'Arginine', 'Carbachol', 'Duodenum', 'Gastrointestinal Motility', 'Male', 'Muscle Relaxation', 'Muscle, Smooth', 'Myoelectric Complex, Migrating', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Papaverine', 'Purinergic P2 Receptor Antagonists', 'Pyloric ... | 9,815,016 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['A03.556.124.684.124', 'A03.556.875.249'], ['G10.261.360'], ['G11.427.494.554'], ['A02.633.570', 'A10.690.467'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predicting Adverse Outcomes in Heart Failure Patients Using Different Frailty Status Measures. | Frailty is an important outcome predictor in older patients. We randomly sampled 12,000 veterans with heart failure diagnosed in 2010. The topic modeling method was applied to identify frailty-related topics from the clinical notes in the electronic medical records. The frailty topics were classified into five deficit ... | ['Aged', 'Frail Elderly', 'Frailty', 'Geriatric Assessment', 'Heart Failure', 'Humans', 'Mental Health', 'Prevalence'] | 29,295,109 | [['M01.060.116.100'], ['M01.060.116.100.540'], ['C23.550.359'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['E05.318.308.985.525.750', 'N... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Knockdown of Long Non-Coding RNA (lncRNA) Colon Cancer-Associated Transcript-1 (CCAT1) Suppresses Oral Squamous Cell Carcinoma Proliferation, Invasion, and Migration by Inhibiting the Discoidin Domain Receptor 2 (DDR2)/ERK/AKT Axis. | BACKGROUND Emerging evidence shows that lncRNAs are involved in carcinogenesis or suppression in diverse cancers. This study assessed the biological role of lncRNA CCAT1 in OSCC and explored the underlying molecule mechanism. MATERIAL AND METHODS CCAT1 and DDR2 expression was measured by qRT-PCR. Colony formation assay... | ['Carcinoma, Squamous Cell', 'Cell Cycle', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Discoidin Domain Receptor 2', 'Gene Expression Regulation, Neoplastic', 'Gene Knockdown Techniques', 'Gene Silencing', 'Humans', 'MAP Kinase Signaling System', 'Mouth Neoplasms', 'Neoplasm Invasiveness', 'Protein Bind... | 32,009,633 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.913.696.620.682.725.400.005.750', 'D12.776.543.750.630.005.750', 'D12.776.543.750.685.050.750', 'D12.776.543.750.705.880.300.750'], ['G0... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Housewife onycholysis. | OBJECTIVE: The aim of this study was to evaluate the clinical and microbiological aspects of onycholysis in Iraqi housewives.METHODS: One hundred housewives with onycholysis of the finger nails were evaluated clinically in the Department of Dermatology and Venereology, Baghdad Teaching Hospital, Baghdad, Iraq between O... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Bacterial Infections', 'Cohort Studies', 'Female', 'Hand Dermatoses', 'Housekeeping', 'Humans', 'Incidence', 'Iraq', 'Middle Aged', 'Nail Diseases', 'Occupational Diseases', 'Risk Factors', 'Severity of Illness Index'] | 16,155,665 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['C01.150.252'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C17.800.338'], ['N02.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.2... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Fatty acid composition and CD36 expression in breast adipose tissue of premenopausal and postmenopausal women. | UNLABELLED: The mammary gland is an organ under complex hormonal and developmental regulation. Among the mediators involved in this process are polypeptides, steroid hormones and certain lipids and their metabolites. The fatty acid content of the breast adipocytes is investigated because of the importance of their role... | ['Adipose Tissue', 'Adult', 'Aged', 'Aged, 80 and over', 'Breast', 'Breast Neoplasms', 'CD36 Antigens', 'Fatty Acids', 'Female', 'Humans', 'Middle Aged', 'Postmenopause', 'Premenopause', 'Triglycerides'] | 9,137,475 | [['A10.165.114'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['D12.776.157.530.300.500', 'D12.776.395.550.625.136', 'D12.776.543.550.625.136', 'D12.776.543.585.300.500', 'D12.776.543.750.011', 'D12.776.543.750.705.675.136', 'D12.776.543.750.705.940.62... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Patient characteristics associated with care by a cardiologist among adults hospitalized with severe congestive heart failure. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. | OBJECTIVES: The goal of this study was to determine factors associated with receiving cardiologist care among patients with an acute exacerbation of congestive heart failure.BACKGROUND: Because cardiologist care for acute cardiovascular illness may improve care, barriers to specialty care could impact patient outcomes.... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cardiology', 'Female', 'Health Services Accessibility', 'Heart Failure', 'Hospitalization', 'Humans', 'Inpatients', 'Male', 'Middle Aged', 'Prospective Studies', 'Socioeconomic Factors', 'United States', 'Workforce'] | 11,127,450 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['H02.403.429.163'], ['N04.590.374.350', 'N05.300.430'], ['C14.280.434'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', ... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Structural characterization of VapB46 antitoxin from Mycobacterium tuberculosis: insights into VapB46-DNA binding. | The ability to form persister cells by Mycobacterium tuberculosis (Mtb) is a prime cause for the emergence of drug-resistant strains. A large number of toxin-antitoxin systems in the Mtb genome are postulated to promote bacterial persistence. The largest family of toxin-antitoxin systems encoded in the genome of Mtb is... | ['Amino Acid Sequence', 'Antitoxins', 'Bacterial Proteins', 'Bacterial Toxins', 'Binding Sites', 'DNA, Bacterial', 'DNA-Binding Proteins', 'Membrane Glycoproteins', 'Models, Molecular', 'Mycobacterium tuberculosis', 'Operon', 'Promoter Regions, Genetic', 'Protein Binding', 'Protein Structure, Tertiary', 'Sequence Homol... | 30,576,065 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114.573.601', 'D12.776.124.790.651.114.573.601', 'D12.776.377.715.548.114.573.601', 'D20.215.401.601'], ['D12.776.097'], ['D23.946.123'], ['G02.111.570.120'], ['D13.444.308.212'], ['D12.776.260'], ['D12.776.395.550', 'D12.776.543.550'], ['E05.599.595'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Damage to the endothelium in Sj?gren's syndrome: lack of correlation with antinuclear antibody titre and presence of antibodies to SSA or SSB autoantigens. | Serum levels of von Willebrand factor antigen (as an index of damage to the endothelium) and tissue antinuclear antibodies and antibodies to SSA (Ro) (which have been associated with vasculitis) and SSB (La) autoantigens were measured in patients with Sj?gren's syndrome. Although high levels of all indices were recorde... | ['Antibodies, Antinuclear', 'Antigens', 'Autoantibodies', 'Endothelium', 'Enzyme-Linked Immunosorbent Assay', 'Humans', "Sjogren's Syndrome", 'von Willebrand Factor'] | 1,575,588 | [['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['D23.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['A10.272.491'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease. | Alzheimer's disease (AD) represents a major healthcare burden with no effective treatment. The glutamate modulator, riluzole, was shown to reverse many AD-related gene expression changes and improve cognition in aged rats. However, riluzole's effect on amyloid beta (Aâ) pathology, a major histopathological hallmark of ... | ['Alzheimer Disease', 'Animals', 'Astrocytes', 'Cognition', 'Disease Models, Animal', 'Gene Expression', 'Hippocampus', 'Male', 'Memory', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Microglia', 'Plaque, Amyloid', 'Receptors, N-Methyl-D-Aspartate', 'Riluzole', 'Sequence Analysis, RNA'] | 30,108,205 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['B01.050'], ['A08.637.200', 'A11.650.200'], ['F02.463.188'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['F02.463.425.540'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.05... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Digital cell image analysis of Ewing's sarcoma. | We analyzed the lesional tissue in Ewing's sarcoma by means of a cell image processor computing 15 nuclear parameters in order to quantify the morphologic variability of the tumor cell nuclei. To this end we combined 32 cases (350-400 Feulgen-stained nuclei analyzed per case) in a data file, which was then subjected to... | ['Cell Nucleus', 'Chromatin', 'DNA', 'Humans', 'Image Processing, Computer-Assisted', 'Periodic Acid-Schiff Reaction', 'Ploidies', 'Sarcoma, Ewing'] | 1,801,834 | [['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D13.444.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.225.500.607.790', 'E01.370.225.500.620.670.615', 'E01.370.225.750.551.790', 'E05.200.500.607.79... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Endothelial cell dysfunction following prolonged activation of progesterone receptor. | Progestin-only contraceptives are associated with breakthrough bleeding in up to 50% of users. The causes of blood vessel rupture are not well understood. Here we report that both normal and Norplant-exposed endothelium express progesterone receptor. Experiments performed in vitro on endothelial cells isolated from hum... | ['Adolescent', 'Adult', 'Basement Membrane', 'Endometrium', 'Endothelium, Vascular', 'Female', 'Humans', 'Levonorgestrel', 'Matrix Metalloproteinase 9', 'Progesterone', 'Progesterone Congeners', 'Promegestone', 'RNA, Messenger', 'Receptors, Progesterone', 'Uterine Hemorrhage'] | 11,041,220 | [['M01.060.057'], ['M01.060.116'], ['A10.272.220', 'A10.615.179'], ['A05.360.319.679.490'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.668.651.693.762.450'], ['D08.811.277.656.300.480.205.360', 'D08.811.277.656.300.480.252.445', 'D08.811.277.656.300.480.525.70... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Low vitamin B6 status in patients with acute myocardial infarction. | The vitamin B6 status of 84 patients with acute myocardial infarction was compared with that of 84 control subjects. Pyridoxal and pyridoxal 5'-phosphate (PLP) in plasma and erythrocytes, as well as the basal and total potential activity of the PLP-dependent enzyme aspartate aminotransferase in erythrocytes, were measu... | ['Aspartate Aminotransferases', 'Erythrocytes', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Pyridoxal', 'Pyridoxal Phosphate', 'Risk Factors', 'Vitamin B 6 Deficiency'] | 2,919,556 | [['D08.811.913.477.700.225'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['D03.383.725.676.925.500'], ['D03.383.725.676.925.500.500', 'D08.211.740'], ['E05.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Colony stimulating activity and continuous flow centrifugation leukapheresis induced proteinuria. | Urinary granulocyte colony stimulating activity (CSA) was studied in normal individulas donating granulocytes. Donors were given corticosteroids 2 h prior to a 4-h leukapheresis using an Aminco celltrifuge in which hydroxyethyl starch was introduced into the donor line. Urine was collected 12-24 h prior to the procedur... | ['Adrenal Cortex Hormones', 'Colony-Forming Units Assay', 'Creatinine', 'Granulocytes', 'Hematopoiesis', 'Humans', 'Leukapheresis', 'Proteinuria'] | 428,475 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Redeveloping the JBI Model of Evidence Based Healthcare. | BACKGROUND: In 2005, Pearson et al. presented a developmental framework of evidence-based practice that sought to situate healthcare evidence and its role and use within the complexity of practice settings globally. A decade later, it was deemed timely to re-examine the Model and its component parts to determine whethe... | ['Bibliometrics', 'Evidence-Based Practice', 'Focus Groups', 'Humans', 'Implementation Science', 'Publishing'] | 29,664,758 | [['L01.178.682.099.325', 'L01.453.183.291'], ['H02.249'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.143.320.400'], ['L01.737']] | ['Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[A late phase II clinical study of cis-diammine glycolato platinum, 254-S, for head and neck cancers]. | A late phase II clinical study of 254-S, a new anticancer platinum complex, for head and neck cancer was conducted by the 254-S Head and Neck Cancer Study Group consisting of 31 institutions. As in the early phase II study for head and neck cancers, 254-S was administered at 100 mg/m2 by 60 min intravenous drip infusio... | ['Adenocarcinoma', 'Adult', 'Aged', 'Antineoplastic Agents', 'Carcinoma, Squamous Cell', 'Drug Administration Schedule', 'Drug Evaluation', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Infusions, Intravenous', 'Male', 'Middle Aged', 'Organoplatinum Compounds'] | 1,605,665 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.319.283'], ['E05.290.625', 'E05.337.425'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['M01.060.116.630'], ['D... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characteristics of solubilized human-somatotropin-binding protein from the liver of pregnant rabbits. | A specific binding site for somatotropin was solubilized by 1% (v/v) Triton X-100 from a crude particulate membrane fraction of pregnant rabbit liver, partially purified and characterized. The solubilized binding site retained many of the characteristics observed in the original particulate fraction, indicating that ex... | ['Animals', 'Binding Sites', 'Cell Membrane', 'Centrifugation, Density Gradient', 'Chromatography, Gel', 'Enzymes', 'Female', 'Growth Hormone', 'Kinetics', 'Liver', 'Pregnancy', 'Rats', 'Receptors, Cell Surface', 'Solubility'] | 6,249,270 | [['B01.050'], ['G02.111.570.120'], ['A11.284.149'], ['E05.181.724.336', 'E05.196.941.336'], ['E05.196.181.400.250'], ['D08.811'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.543.750'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induction of hypertension and cardiac hypertrophy in guinea pig by DOCA salt. | Experimental hypertension can be induced in rats by uninephrectomy, administration of deoxycorticosterone acetate (DOCA) and sodium chloride. We developed this model in the guinea pig, because it presents an isoenzymic myosin pattern and calcium-induced calcium release similar to those of humans. Unilateral nephrectomy... | ['Analysis of Variance', 'Animals', 'Blood Pressure', 'Blood Pressure Determination', 'Body Weight', 'Desoxycorticosterone', 'Disease Models, Animal', 'Female', 'Guinea Pigs', 'Heart Rate', 'Heart Ventricles', 'Hypertension', 'Hypertrophy, Left Ventricular', 'Injections, Intramuscular', 'Injections, Subcutaneous', 'Iso... | 7,837,830 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140', 'E01.370.600.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D04.210.500.745.745.654.339', 'D06.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of xylazine on canine coronary artery vascular rings. | OBJECTIVE: To determine the effects of xylazine on canine coronary artery smooth muscle tone.SAMPLE POPULATION: Hearts of 26 healthy dogs.PROCEDURE: Dogs were anesthetized with pentobarbital, and vascular rings of various diameters were prepared from the epicardial coronary arteries. Vascular rings were placed in tissu... | ['Analysis of Variance', 'Animals', 'Coronary Vessels', 'Dogs', 'Dose-Response Relationship, Drug', 'Imidazoles', 'Muscle Tonus', 'Prazosin', 'Vasoconstriction', 'Xylazine'] | 15,077,684 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['A07.015.114.269', 'A07.015.908.194'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.383.129.308'], ['G11.427.565'], ['D03.633.100.786.750'], ['G09.330.380.925'], ['D02.886.665.985', 'D03.383.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Peri-implant bone defects: A 1-year follow-up comparative study of use of hyaluronic acid and xenografts. | Objective: The aim of this study was to compare the efficacy of hyaluronic acid (HA) and xenografts on the repair of peri-implant dehiscence-type bone defects occur during implant placement.Patients and Methods: Forty-two dehiscence Class I type defects located on the buccal surface of the implants were included in thi... | ['Adult', 'Alveolar Bone Loss', 'Alveolar Ridge Augmentation', 'Bone Regeneration', 'Collagen', 'Cone-Beam Computed Tomography', 'Cross-Sectional Studies', 'Dental Implants', 'Female', 'Follow-Up Studies', 'Heterografts', 'Humans', 'Hyaluronic Acid', 'Male', 'Middle Aged', 'Treatment Outcome'] | 31,607,728 | [['M01.060.116'], ['C05.116.264.150', 'C07.465.714.354.500'], ['E04.545.550.100', 'E06.645.550.100'], ['G11.427.213.140', 'G16.762.150.150'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.50... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
A National Examination Of Long-Term Care Setting, Outcomes, And Disparities Among Elderly Dual Eligibles. | The benefits of expanding funding for Medicaid long-term care home and community-based services (HCBS) relative to institutional care are often taken as self-evident. However, little is known about the outcomes of these services, especially for racial and ethnic minority groups, whose members tend to use the services m... | ['Aged', 'Aged, 80 and over', 'Community Health Services', 'Dual MEDICAID MEDICARE Eligibility', 'Ethnic Groups', 'Female', 'Healthcare Disparities', 'Home Care Services', 'Humans', 'Long-Term Care', 'Medicaid', 'Medicare', 'United States'] | 31,260,370 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['N02.421.143'], ['N03.109'], ['M01.686.754', 'N01.224.317'], ['N04.590.374.380', 'N05.300.493'], ['N02.421.143.524', 'N02.421.539.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.476', 'N02.421.585.476'], ['N03.219.521.346.506.564.655', 'N03.706.615.693']... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. | In human neuroblastoma, amplification of the MYCN gene predicts poor prognosis and resistance to therapy. Because hypoxia contributes to aggressive tumor phenotypes, predominantly via two structurally related hypoxia inducible factors, HIF-1á and HIF-2á, we examined hypoxia responses in MYCN-amplified neuroblastoma cel... | ['Animals', 'Cell Cycle', 'Cell Hypoxia', 'Disease Progression', 'Female', 'Gene Amplification', 'Genes, myc', 'HCT116 Cells', 'Humans', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Isoenzymes', 'L-Lactate Dehydrogenase', 'Lactate Dehydrogenase 5', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Neuroblastoma', 'Transpl... | 20,961,996 | [['B01.050'], ['G04.144'], ['G03.197.300', 'G04.270.300'], ['C23.550.291.656'], ['G05.308.250', 'G05.365.590.310', 'G05.558.315'], ['G05.360.340.024.340.375.500.791.420'], ['A11.251.210.190.380', 'A11.251.860.180.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.260.103.625.750', 'D12.776.930.125.625.75... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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