Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Signal transduction pathway analysis in desmoid-type fibromatosis: transforming growth factor-â, COX2 and sex steroid receptors. | Despite reports of sex steroid receptor and COX2 expression in desmoid-type fibromatosis, responses to single agent therapy with anti-estrogens and non-steroidal anti-inflammatory drugs are unpredictable. Perhaps combination pharmacotherapy might be more effective in desmoid tumors that co-express these targets. Clearl... | ['Adolescent', 'Adult', 'Bone Morphogenetic Proteins', 'Child', 'Child, Preschool', 'Cyclooxygenase 2', 'Estrogen Receptor beta', 'Female', 'Fibromatosis, Aggressive', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Receptors, Androgen', 'Signal Transduction', 'Smad2 Protein', 'Transforming Growth Factor beta', 'beta Caten... | 23,035,734 | [['M01.060.057'], ['M01.060.116'], ['D12.644.276.954.200', 'D12.776.467.942.200', 'D23.529.942.200'], ['M01.060.406'], ['M01.060.406.448'], ['D08.811.600.720.750'], ['D12.776.826.750.350.262'], ['C04.557.450.565.590.340.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['D12.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Basal astrocyte and microglia activation in the central nervous system of Familial Hemiplegic Migraine Type I mice. | BACKGROUND: Gain-of-function missense mutations in the á1A subunit of neuronal CaV2.1 channels, which define Familial Hemiplegic Migraine Type 1 (FHM1), result in enhanced cortical glutamatergic transmission and a higher susceptibility to cortical spreading depolarization. It is now well established that neurons signal... | ['Animals', 'Astrocytes', 'Central Nervous System', 'Cerebellar Ataxia', 'Gene Knock-In Techniques', 'Humans', 'Male', 'Mice', 'Mice, Transgenic', 'Microglia', 'Migraine Disorders', 'Random Allocation', 'Trigeminal Ganglion'] | 31,260,335 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['A08.186'], ['C10.228.140.252.190', 'C10.597.350.090.500', 'C23.888.592.350.090.200'], ['E05.393.335.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'],... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. | BACKGROUND: Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism.METHODS/PRINCIPAL FINDINGS: Twent... | ['Aged', 'Cation Transport Proteins', 'China', 'Cyclin-Dependent Kinase 5', 'Cyclin-Dependent Kinase Inhibitor p15', 'Cyclin-Dependent Kinase Inhibitor p16', 'Diabetes Mellitus, Type 2', 'Female', 'Gene Expression Regulation', 'Homeodomain Proteins', 'Humans', 'Insulysin', 'Kinesin', 'Male', 'Middle Aged', 'PPAR gamma'... | 19,862,325 | [['M01.060.116.100'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['Z01.252.474.164'], ['D08.811.913.696.620.682.700.646.500.500.500', 'D12.644.360.250.067.875', 'D12.776.167.200.067.875', 'D12.776.476.250.067.875'], ['D12.644.360.225.100', 'D12.776.167.187.100', 'D12.776.476.225.100', 'D12.776.624.776.355.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. | AIMS/HYPOTHESIS: In humans, the rate of beta cell proliferation declines rapidly during the postnatal period and remains low throughout adult life. Recent studies suggest that this may reflect the distribution of cell cycle regulators which, unusually, are located in the cytosolic compartment of beta cells in islets is... | ['Adolescent', 'Adult', 'Aged', 'Biological Specimen Banks', 'Cell Nucleus', 'Cell Proliferation', 'Child', 'Child, Preschool', 'Cyclin D1', 'Cyclin D2', 'Cyclin D3', 'Cytosol', 'Female', 'Humans', 'Immunohistochemistry', 'Insulin-Secreting Cells', 'Islets of Langerhans Transplantation', 'Male', 'Microscopy, Fluorescen... | 26,055,066 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['N02.278.065'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.161.750', 'G07.345.249.410.750'], ['M01.060.406'], ['M01.060.406.448'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['D12.6... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase. | BACKGROUND: Neutral endopeptidase, also known as neprilysin and abbreviated NEP, is considered to be one of the key enzymes in initial human amyloid-beta (Abeta) degradation. The aim of our study was to explore the impact of NEP deficiency on the initial development of dementia-like symptoms in mice.METHODOLOGY/PRINCIP... | ['Aging', 'Amygdala', 'Amyloid beta-Peptides', 'Animals', 'Dementia', 'Galanin', 'Glucagon-Like Peptide 1', 'Hippocampus', 'Learning', 'Long-Term Potentiation', 'Memory', 'Mice', 'Neprilysin', 'Peptide Fragments'] | 19,240,795 | [['G07.345.124'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['C10.228.140.380', 'F03.615.400'], ['D12.644.400.250', 'D12.776.631.650.250'], ['D06.472.317.680.500.500'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Potassium, sodium, and the intracellular fluid space of cells from bone. | Cells enzymatically dispersed from fetal rat calvaria were analyzed for sodium and potassium content and intracellular fluid space (ICF). Even when obtained in comparatively high yield, the cells are damaged by the isolation procedure as evidenced by high sodium and low potassium content immediately after isolation. Du... | ['Animals', 'Body Fluids', 'Bone and Bones', 'Cell Separation', 'DNA', 'Erythrocytes', 'Extracellular Space', 'Intracellular Fluid', 'Potassium', 'Rats', 'Sodium'] | 116,751 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Introducing molecular testing of pyrazinamide susceptibility improves multidrug-resistant tuberculosis treatment outcomes: a prospective cohort study. | The current treatment for multidrug-resistant tuberculosis (MDR-TB) takes a lengthy period of 18-24 months and has a poor cure rate of 50-60%. A multicenter, prospective cohort study was conducted to assess the role of testing for molecular susceptibility to pyrazinamide (PZA) in optimising treatment for MDR-TB.We assi... | ['Adult', 'Amidohydrolases', 'Antitubercular Agents', 'China', 'Drug Resistance, Multiple, Bacterial', 'Female', 'Humans', 'Logistic Models', 'Male', 'Microbial Sensitivity Tests', 'Middle Aged', 'Multivariate Analysis', 'Mutation', 'Mycobacterium tuberculosis', 'Prospective Studies', 'Pyrazinamide', 'Treatment Outcome... | 30,578,402 | [['M01.060.116'], ['D08.811.277.087'], ['D27.505.954.122.085.255'], ['Z01.252.474.164'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
LCA of integrated MSW management systems: case study of the Bologna District. | LCA as a decision-supporting tool in planning integrated municipal solid waste management is not, as yet, widely used in Italy. This paper presents a study concerning the application of the LCA methodology to support the development of the new waste management plan for the Bologna District. The main goal of the study w... | ['Air Pollution', 'Carbon Dioxide', 'Conservation of Natural Resources', 'Decision Support Techniques', 'Greenhouse Effect', 'Italy', 'Refuse Disposal', 'Soil'] | 17,418,562 | [['N06.850.460.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['J01.256', 'N06.230.080'], ['E05.245', 'L01.313.500.750.190'], ['G16.500.175.827', 'N06.230.265'], ['Z01.542.489'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. | Oxylipins, the oxidation products of unsaturated fatty acids (FA), are potent endogenous mediators being involved in the regulation of various biological processes such as inflammation, pain and blood coagulation. Compared to oxylipins derived from arachidonic acid (AA) by cyclooxygenase action, i.e. prostanoides, only... | ['12-Hydroxy-5,8,10,14-eicosatetraenoic Acid', 'Adult', 'Arachidonic Acid', 'Eicosapentaenoic Acid', 'Fatty Acids, Omega-3', 'Fatty Acids, Unsaturated', 'Humans', 'Hyperlipidemias', 'Male', 'Middle Aged', 'alpha-Linolenic Acid'] | 23,694,766 | [['D10.251.355.255.100.300.425', 'D10.251.355.310.166.550.425'], ['M01.060.116'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['D10.212.302.380.410.385', 'D10.251.355.255.200', 'D10.251.355.337.290', 'D10.627.430.450.390'], ['D10.212.302.380.410', 'D10.251.355.337', 'D10.627.430.450'], ['D10.251.355'], ['B0... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
GC/MS analysis of m-hydroxybenzoylecgonine in urine. Forensic implication in cocaine use. | m-Hydroxybenzoylecgonine (m-OH-BE) and d3-m- hydroxybenzoylecgonine (d3-m-OH-BE) have been synthesized, and a GC/MS procedure with d3-m-OH-BE as internal standard has been developed. Among 24 human urine specimens that were positive for BE, all of them have shown detectable levels of m-OH-BE with 75% of the specimens e... | ['Cocaine', 'Cocaine-Related Disorders', 'Forensic Medicine', 'Gas Chromatography-Mass Spectrometry', 'Humans'] | 9,891,608 | [['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['C25.775.300', 'F03.900.300'], ['H02.403.330', 'I01.198.780.937'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
Diabetic mastopathy in men: imaging findings in two patients. | The classic imaging findings of diabetic mastopathy, an uncommon entity manifesting in patients with a history of long-standing insulin-dependent diabetes mellitus, have been reported in the literature in women but not, to the authors' knowledge, in men. Two men with diabetic mastopathy presented with palpable breast m... | ['Adult', 'Breast', 'Breast Diseases', 'Breast Neoplasms, Male', 'Diabetes Mellitus, Type 1', 'Diagnosis, Differential', 'Female', 'Humans', 'Male', 'Mammography', 'Middle Aged', 'Ultrasonography, Mammary'] | 11,376,272 | [['M01.060.116'], ['A01.236'], ['C17.800.090'], ['C04.588.180.260', 'C17.800.090.500.260'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.500'], ['M01.060.116.630'], ['E01.370.350.850.860', 'E01.370.378.850']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Intracellular localization of human DNA repair enzyme methylguanine-DNA methyltransferase by antibodies and its importance. | The human DNA repair enzyme, methylguanine-DNA methyltransferase (MGMT, M(r) 21,000), which protects cells against the mutagenic effect of alkylating carcinogens, was found to be localized in the cell nucleus (except the nucleolus) by immunofluorescence staining using polyclonal and monoclonal antibodies. The supportin... | ['Amino Acid Sequence', 'Antibodies', 'Antibody Specificity', 'Blotting, Western', 'Cell Line, Transformed', 'Cell Nucleus', 'Escherichia coli', 'HeLa Cells', 'Humans', 'Methyltransferases', 'Molecular Sequence Data', 'O(6)-Methylguanine-DNA Methyltransferase', 'Staining and Labeling'] | 1,384,961 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G12.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.172'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B03... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Deep sequencing of small RNA repertoires in mice reveals metabolic disorders-associated hepatic miRNAs. | Obesity and associated metabolic disorders contribute importantly to the metabolic syndrome. On the other hand, microRNAs (miRNAs) are a class of small non-coding RNAs that repress target gene expression by inducing mRNA degradation and/or translation repression. Dysregulation of specific miRNAs in obesity may influenc... | ['Animals', 'Cell Line', 'Disease Models, Animal', 'Fatty Acids, Nonesterified', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Hepatocytes', 'High-Throughput Nucleotide Sequencing', 'Lipid Metabolism', 'Liver', 'Male', 'Metabolic Diseases', 'Mice', 'MicroRNAs', 'Multigene Family', 'Obesity', 'Reproducibil... | 24,260,478 | [['B01.050'], ['A11.251.210'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D10.251.310'], ['E05.393.332'], ['G05.308'], ['A11.436.348'], ['E05.393.760.319'], ['G03.458'], ['A03.620'], ['C18.452'], ['B01.050.150.900.649.313.992.635.505.500'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Structural asymmetry of the terminal catalytic complex in selenocysteine synthesis. | Selenocysteine (Sec), the 21(st) amino acid, is synthesized from a serine precursor in a series of reactions that require selenocysteine tRNA (tRNA(Sec)). In archaea and eukaryotes, O-phosphoseryl-tRNA(Sec):selenocysteinyl-tRNA(Sec) synthase (SepSecS) catalyzes the terminal synthetic reaction during which the phosphose... | ['Allosteric Site', 'Amino Acyl-tRNA Synthetases', 'Catalytic Domain', 'Diffusion', 'Escherichia coli', 'Humans', 'Light', 'Protein Interaction Mapping', 'Protein Multimerization', 'RNA', 'RNA, Transfer', 'Scattering, Radiation', 'Selenocysteine', 'Tryptophan', 'Ultracentrifugation', 'X-Ray Diffraction'] | 25,190,812 | [['G02.111.570.120.147'], ['D08.811.464.263.200'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['G01.202', 'G02.196'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Excess processing of oxidative damaged bases causes hypersensitivity to oxidative stress and low dose rate irradiation. | Ionizing radiations such as X-ray and ã-ray can directly or indirectly produce clustered or multiple damages in DNA. Previous studies have reported that overexpression of DNA glycosylases in Escherichia coli (E. coli) and human lymphoblast cells caused increased sensitivity to ã-ray and X-ray irradiation. However, the ... | ['Biomarkers', 'DNA Breaks, Double-Stranded', 'DNA Damage', 'DNA Glycosylases', 'DNA Repair', 'Enzyme Induction', 'Gamma Rays', 'Guanine', 'HeLa Cells', 'Heavy Ions', 'Histones', 'Humans', 'Hydrogen Peroxide', 'Hydroxyl Radical', 'Micronucleus Tests', 'Oxidative Stress', 'Radiation Tolerance', 'Recombinant Fusion Prote... | 26,059,740 | [['D23.101'], ['G05.200.210.220'], ['G05.200'], ['D08.811.074.249', 'D08.811.277.450.430.099'], ['G02.111.222', 'G05.219'], ['G05.308.320.200'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['D03.633.100.759.758.399.454'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['G01.249.467'],... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Calibrationless quantitative analysis by indirect UV absorbance detection in capillary zone electrophoresis: the concept of the conversion factor. | A new, fast and efficient procedure is described for the simultaneous quantitative analysis of various non-UV absorbing species in a sample, by capillary zone electrophoresis with indirect UV absorbance detection. The procedure is based on the concept of the conversion factor (CF). The CF of an analyte is defined as th... | ['Calibration', 'Cations', 'Electrophoresis, Capillary', 'Models, Theoretical'] | 14,743,486 | [['E05.978.155'], ['D01.248.497.300'], ['E05.196.401.190', 'E05.301.300.190'], ['E05.599']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improving behavior using child-directed interaction skills: A case study determining cochlear implant candidacy. | OBJECTIVE AND IMPORTANCE: Children with hearing loss (HL) are at increased risk of developing externalizing behavior problems (e.g., hyperactivity, attention problems). These problems can lead to cascading effects on children's overall development. However, few studies have identified evidence-based interventions for t... | ['Audiometry', 'Behavior Therapy', 'Child', 'Child Behavior Disorders', 'Cochlear Implantation', 'Family Therapy', 'Hearing Loss, Bilateral', 'Humans', 'Male', 'Patient Selection'] | 25,856,530 | [['E01.370.382.375.060'], ['F04.754.137'], ['M01.060.406'], ['F03.625.141'], ['E04.580.450.220', 'E04.650.220'], ['F04.754.864.581.273'], ['C09.218.458.341.374', 'C10.597.751.418.341.374', 'C23.888.592.763.393.341.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581.500.653', 'N04.590.731']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
External validity of a cardiovascular screening including a coronary artery calcium examination in middle-aged individuals from the general population. | Background Coronary artery calcium is important in cardiovascular risk stratification, but this knowledge is based on studies with a significant selection bias. This study aims to evaluate the external validity of a screening programme including coronary artery calcium examination, and the association between coronary ... | ['Calcium', 'Coronary Angiography', 'Coronary Artery Disease', 'Coronary Vessels', 'Denmark', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Male', 'Mass Screening', 'Middle Aged', 'Predictive Value of Tests', 'Prospective Studies', 'Risk Assessment', 'Risk Factors', 'Tomography, X-Ray Computed', 'Vascular Calc... | 29,719,966 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['A07.015.114.269', 'A07.015.908.194'], ['Z01.542.816.124'], ['E05.318.372.500.750.249', 'N05.7... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Regulation of glucose metabolism in rat adrenal gland in alloxan-diabetes: the possible role of fructose 2,6-bisphosphate. | The level of fructose 2,6-bisphosphate is markedly decreased in the rat V.renal gland in diabetes, falling to 23% of the control value. There is parallel decrease in the flux of 14C-labelled glucose through the glycolytic route and tricarboxylic acid cycle. Only minimal changes in hexokinase (EC 2.7.1.1.), a 22% decrea... | ['Adrenal Glands', 'Animals', 'Citric Acid Cycle', 'Diabetes Mellitus, Experimental', 'Fructosediphosphates', 'Glucose', 'Glycolysis', 'Hexokinase', 'Hexosediphosphates', 'Isoenzymes', 'Male', 'Pentosephosphates', 'Rats', 'Rats, Inbred Strains'] | 6,547,341 | [['A06.300.071'], ['B01.050'], ['G02.111.165', 'G03.295.342', 'G03.493.170'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D09.894.417.313.300', 'D09.894.417.592.300'], ['D09.947.875.359.448'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['D08.811.913.696.620.300'], ['D09.894.417.5... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Correlation between plasma fibronectin level and experimental rat heat stress mortality. | Reticuloendothelial system (RES) clearance function correlates with the mortality rate associated with stresses that can induce shock. Likewise, experimental rat heat stress (ERHS) mortality rate is altered by modulation of RES function. Since plasma fibronectin (PF) in many instances appears to mediate in vivo phagocy... | ['Animals', 'Fibronectins', 'Hot Temperature', 'Male', 'Mononuclear Phagocyte System', 'Rats', 'Stress, Physiological'] | 4,055,560 | [['B01.050'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['A15.382.670'], ['B01.050.150.900.649.313.992.635.505.700'], ['G07.775']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Respiratory compensation and blood pH regulation during variable intensity exercise in trained versus untrained subjects. | To determine whether endurance-trained cyclists (T; n = 10) have a superior blood-respiratory buffering for metabolic acidosis relative to untrained subjects (UT; n = 10) during variable intensity exercise (VAR). On three occasions, T and UT pedaled for 24 min alternating high- and low-intensities as percentage of thei... | ['Adaptation, Physiological', 'Anaerobic Threshold', 'Blood Chemical Analysis', 'Humans', 'Hydrogen-Ion Concentration', 'Male', 'Physical Exertion', 'Physical Fitness', 'Pulmonary Ventilation', 'Young Adult'] | 19,513,741 | [['G07.025', 'G16.012.500'], ['G03.680.110', 'G11.427.680.134'], ['E01.370.225.124.100', 'E05.200.124.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['G11.427.683'], ['G11.427.685', 'I03.450.642.845.054.800', 'N01.400.545'], ['E01.370.386.700.660', 'G09.772.650'], ['M01.060.116.815']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A novel strategy to screen inhibitors of multiple aminoglycoside-modifying enzymes with ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. | Resistance to aminoglycoside antibiotics occurs primarily as a result of aminoglycoside-modification enzymes (AMEs) that modify the antibiotics. In this work, a novel strategy to combat the effects of antibiotic resistance was developed by screening multiple AMEs inhibitors with ultra-high performance liquid chromatogr... | ['Acetyltransferases', 'Aminoglycosides', 'Anti-Bacterial Agents', 'Bacterial Proteins', 'Chromatography, High Pressure Liquid', 'Drug Discovery', 'Drug Evaluation, Preclinical', 'Drug Resistance, Multiple, Bacterial', 'Enzyme Assays', 'Enzyme Inhibitors', 'Indoles', 'Phosphotransferases (Alcohol Group Acceptor)', 'Pyr... | 30,458,385 | [['D08.811.913.050.134'], ['D09.408.051'], ['D27.505.954.122.085'], ['D12.776.097'], ['E05.196.181.400.300'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['E05.290.750', 'E05.337.550'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['E05.196.427'], ['D27.50... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Intermolecular contacts influencing the conformational and geometric features of the pharmaceutically preferred mebendazole polymorph C. | Mebendazole (MBZ) is a common benzimidazole anthelmintic that exists in three different polymorphic forms, A, B, and C. Polymorph C is the pharmaceutically preferred form due to its adequated aqueous solubility. No single crystal structure determinations depicting the nature of the crystal packing and molecular conform... | ['Antinematodal Agents', 'Crystallization', 'Crystallography, X-Ray', 'Dimerization', 'Humans', 'Hydrogen Bonding', 'Mebendazole', 'Molecular Conformation', 'Solubility'] | 18,855,910 | [['D27.505.954.122.250.075.080'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['G02.206', 'G03.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.282'], ['D02.241.081.251.415', 'D03.633.100.103.600'], ['G02.111.570.820'], ['G02.805']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A higher alanine aminotransferase level correlates with earlier hepatitis B e antigen seroconversion in lamivudine-treated chronic hepatitis B patients. | BACKGROUND/AIMS: A pretherapy serum alanine aminotransferase (ALT) level above five times the upper limit of normal (ULN) is known to predict hepatitis B e antigen (HBeAg) seroconversion during lamivudine therapy for chronic hepatitis B patients. However, whether an even higher pretherapy serum ALT value or other viral... | ['Adolescent', 'Adult', 'Aged', 'Alanine Transaminase', 'DNA, Viral', 'Female', 'Hepatitis B e Antigens', 'Hepatitis B, Chronic', 'Humans', 'Lamivudine', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Retrospective Studies', 'Reverse Transcriptase Inhibitors', 'Young Adult'] | 18,492,018 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D08.811.913.477.700.100'], ['D13.444.308.568'], ['D23.050.327.495.500.469'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C06.552.380.705.437.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Flight-induced changes in human amino acid excretion. | A biomedical appraisal of flight stress was made by means of a battery of urinary determinations on crewmen who participated in a 96-h airborne alert. The crewmen were divided into three teams, each consisting of 16 members and each manning an EC-135J aircraft. These teams took turns so as to assure that one team was a... | ['Adaptation, Physiological', 'Aerospace Medicine', 'Amino Acids', 'Circadian Rhythm', 'Creatinine', 'Humans', 'Male', 'Methylhistidines', 'Nitrogen', 'Stress, Physiological', 'Urea'] | 1,247,428 | [['G07.025', 'G16.012.500'], ['H02.403.029'], ['D12.125'], ['G07.180.562.190'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.072.329.539'], ['D01.268.604', 'D01.362.625'], ['G07.775'], ['D02.065.950']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Vitamin C effect on mitoxantrone-induced cytotoxicity in human breast cancer cell lines. | In recent years the use of natural dietary antioxidants to minimize the cytotoxicity and the damage induced in normal tissues by antitumor agents is gaining consideration. In literature, it is reported that vitamin C exhibits some degree of antineoplastic activity whereas Mitoxantrone (MTZ) is a synthetic anti-cancer d... | ['Antineoplastic Agents', 'Antioxidants', 'Apoptosis', 'Ascorbic Acid', 'Breast Neoplasms', 'Cell Line, Tumor', 'Female', 'G2 Phase Cell Cycle Checkpoints', 'Histones', 'Humans', 'M Phase Cell Cycle Checkpoints', 'MCF-7 Cells', 'Mitoxantrone', 'Phosphatidylinositol 3-Kinases', 'Signal Transduction'] | 25,531,443 | [['D27.505.954.248'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G04.146.954.035'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.144.109.500', 'G04.144.500.340.500'], ['D12.776.157.687.485', 'D12.77... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acid-base disturbances in acute poisoning and their association with survival. | PURPOSE: The purpose was to investigate the association between acid-base disturbances and mortality in acute poisoning.MATERIALS AND METHODS: We performed a retrospective cross-sectional exploratory study on all acutely poisoned patients older than 12 years who had been admitted to the main tertiary toxicology hospita... | ['Acidosis', 'Adult', 'Aged', 'Blood Gas Analysis', 'Critical Care', 'Cross-Sectional Studies', 'Female', 'Hospitalization', 'Humans', 'Hydrogen-Ion Concentration', 'Intensive Care Units', 'Iran', 'Male', 'Middle Aged', 'Point-of-Care Testing', 'Poisoning', 'Psychotropic Drugs', 'Retrospective Studies', 'Survival Analy... | 27,481,740 | [['C18.452.076.176'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E02.760.190', 'N02.421.585.190'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Myopia: a collagen disease? | Myopia is an increasingly important public health problem in the world. Even though previous studies have strongly implicated a role of certain environmental factors such as visual near-work in myopia development, the pathogenesis of this disease still remains unclear. There is evidence showing that myopia is primarily... | ['Collagen', 'Collagen Diseases', 'Humans', 'Models, Biological', 'Myopia', 'Sclera', 'Scleral Diseases'] | 19,616,386 | [['D05.750.078.280', 'D12.776.860.300.250'], ['C17.300.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['C11.744.636'], ['A09.371.784'], ['C11.790']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differences in oxygen-dependent regulation of enzymes between tumor and normal cell systems in culture. | Metabolic studies in tumor cells have indicated that bioenergetic regulatory mechanisms geared to acute changes in oxygen availability are abnormal. In the present studies we have examined bioenergetic adaptations to chronic oxygen depletion in culture maintained tumor cells in comparison to normal cell lines. Activiti... | ['Cell Line', 'Cells, Cultured', 'Electron Transport Complex IV', 'Energy Metabolism', 'Glycolysis', 'Hypoxia', 'Lung', 'Neoplasms, Experimental', 'Phosphofructokinase-1', 'Pyruvate Kinase', 'Superoxide Dismutase'] | 6,270,167 | [['A11.251.210'], ['A11.251'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776.543.585.450.250.875.484'], ['G03.295'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['C23.888.852.079'], ['A04.411'], ['C04.619', 'E05.598... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HIPAA compliance not so great? Maybe it's time to coordinate. | Healthcare laws and regulations these days, particularly HIPAA and its associated technology implications, have become a maze of layers that intrude on everyday operations and require new approaches to compliance. | ['Government Regulation', 'Guideline Adherence', 'Health Insurance Portability and Accountability Act', 'Hospital Administration', 'Risk Management', 'United States'] | 17,883,240 | [['I01.880.604.394', 'N03.706.358'], ['N04.761.337', 'N05.715.360.395'], ['N03.219.521.576.343.349', 'N03.706.615.273'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['N03.219.463.800', 'N04.452.871'], ['Z01.107.567.875']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome--an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13. | We present clinical, radiological, biochemical, and genetic findings on six patients from two consanguineous families that show EDS-like features and radiological findings of a mild skeletal dysplasia. The EDS-like findings comprise hyperelastic, thin, and bruisable skin, hypermobility of the small joints with a tenden... | ['Adult', 'Amino Acid Sequence', 'Amino Acids', 'Base Sequence', 'Cation Transport Proteins', 'Child', 'Child, Preschool', 'Collagen', 'Consanguinity', 'DNA', 'Ehlers-Danlos Syndrome', 'Female', 'Genes, Recessive', 'Haplotypes', 'Humans', 'Male', 'Molecular Sequence Data', 'Mutation', 'Pedigree', 'Phenotype', 'Sequence... | 18,513,683 | [['M01.060.116'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['M01.060.406'], ['M01.060.406.448'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G05.090.403.180', 'G05.180'], ['D13.444.308'],... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
The influence of prior therapy on the success of trabeculectomy. | The role of early surgery in the management of primary open angle glaucoma is under debate. To determine whether previous medical therapy influences the outcome of subsequent trabeculectomy, we retrospectively reviewed the results of surgery in two groups of patients. The first group underwent primary trabeculectomy, h... | ['Aged', 'Female', 'Glaucoma, Open-Angle', 'Humans', 'Laser Therapy', 'Male', 'Middle Aged', 'Ophthalmic Solutions', 'Preoperative Care', 'Prognosis', 'Retrospective Studies', 'Statistics as Topic', 'Trabeculectomy'] | 2,244,836 | [['M01.060.116.100'], ['C11.525.381.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['M01.060.116.630'], ['D26.776.708.645', 'D27.505.954.578.645', 'D27.720.752.608'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Critical assessment of three high performance liquid chromatography analytical methods for food carotenoid quantification. | Three sets of extraction/saponification/HPLC conditions for food carotenoid quantification were technically and economically compared. Samples were analysed for carotenoids alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, lycopene, and zeaxanthin. All methods demonstrated good performance in the analysis of a... | ['Acetonitriles', 'Analysis of Variance', 'Carotenoids', 'Chromatography, High Pressure Liquid', 'Food Analysis', 'Fruit', 'Furans', 'Methanol', 'Vegetables'] | 20,399,439 | [['D02.626.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['E05.196.181.400.300'], ['E05.362', 'J01.576.423.850.100'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['D03.383.312'], ['D02.03... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Ureteral catheterization and patient mobilization: is bed restriction mandatory? | OBJECTIVES: We determined whether patient mobilization influences ureteral catheter position in the collecting system.METHODS: 26 consecutive patients (28 renal units) who underwent ureteral catheterization for the purpose of retrograde pyelography or the relief of ureteral obstruction, were included. The position of t... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Immobilization', 'Male', 'Middle Aged', 'Posture', 'Prospective Studies', 'Radiography', 'Reference Values', 'Sensitivity and Specificity', 'Ureteral Obstruction', 'Urinary Catheterization'] | 10,450,009 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.472'], ['M01.060.116.630'], ['G11.427.695'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.700'], ['E05.978.810'], ['E05.318.370.800', 'E05.318.740.87... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dynamics of actin-based movement by Rickettsia rickettsii in vero cells. | Actin-based motility (ABM) is a virulence mechanism exploited by invasive bacterial pathogens in the genera Listeria, Shigella, and Rickettsia. Due to experimental constraints imposed by the lack of genetic tools and their obligate intracellular nature, little is known about rickettsial ABM relative to Listeria and Shi... | ['Actins', 'Animals', 'Cell Nucleus', 'Chlorocebus aethiops', 'Half-Life', 'Microscopy, Fluorescence', 'Movement', 'Rickettsia rickettsii', 'Vero Cells', 'Virulence'] | 10,417,192 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['G01.910.405'], ['E01.370.350.515.458', 'E05.595.458'], ['G07.568', 'G11.427.410'], ['B03.660.050.783.875.650.650.650'], ['A1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tumor seeding in urological laparoscopy: an international survey. | PURPOSE: During the last 10 years laparoscopy has been applied to treat most urological pathology including malignancies. There has been concern regarding peritoneal dissemination and port site metastases. We undertook a survey to assess the incidence of this occurrence.MATERIALS AND METHODS: A total of 50 internationa... | ['Follow-Up Studies', 'Global Health', 'Humans', 'Laparoscopy', 'Neoplasm Metastasis', 'Neoplasm Seeding', 'Surveys and Questionnaires', 'Time Factors', 'Urologic Neoplasms'] | 15,126,775 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C04.697.650', 'C23.550.727.650'], ['C04.697.650.830', 'C23.550.727.650.830'], ['E05.318.308.980', 'N0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model. | BACKGROUND: Posterior capsule opacification (PCO) after cataract surgery is influenced by intraocular lens (IOL) design and material. The following is an ex vivo comparison of PCO between the Clareon vs. the AcrySof IOL in human capsular bags.METHODS: Twenty cadaver capsular bags from 10 human donors were used, with th... | ['Actins', 'Aged', 'Capsule Opacification', 'Cells, Cultured', 'Collagen Type I', 'Fibronectins', 'Fluorescent Antibody Technique, Indirect', 'Humans', 'Lens Implantation, Intraocular', 'Lenses, Intraocular', 'Middle Aged', 'Phacoemulsification', 'Posterior Capsule of the Lens', 'Prosthesis Design', 'Tissue Donors', 'V... | 32,103,739 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['M01.060.116.100'], ['C11.510.245.500'], ['A11.251'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['E01.370.225.500.607.512.240.310', 'E0... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease. | Parkinson's disease is assumed to be caused by mitochondrial dysfunction in the affected dopaminergic neurons in the brain. We have recently created small chemicals, KUSs (Kyoto University Substances), which can reduce cellular ATP consumption. By contrast, agonistic ligands of ERRs (estrogen receptor-related receptors... | ['Adenosine Triphosphate', 'Animals', 'Cell Death', 'Culture Media', 'Disease Models, Animal', 'Estrogens', 'Glycolysis', 'Glycosides', 'HEK293 Cells', 'Humans', 'Mice', 'Mitochondria', 'PC12 Cells', 'Parkinson Disease', 'Pregnenolone', 'Rats', 'Small Molecule Libraries'] | 28,780,078 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['G04.146'], ['D27.720.470.305', 'E07.206'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D27.505.696.399.472.277'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['D09.408'], ['A11.251.210.172.750', 'A1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3' IsomiR species and DNA contamination influence reliable quantification of microRNAs by stem-loop quantitative PCR. | MicroRNAs (miRNAs) are ?20-24 nucleotide-long regulatory RNAs that have been proven to play important roles in many cellular processes. Since their discovery, a number of different techniques have been developed to detect and accurately quantify them. For individual mature miRNA measurements, quantitative stem-loop rea... | ['DNA Contamination', 'Gene Expression Profiling', 'HeLa Cells', 'Humans', 'MicroRNAs', 'Real-Time Polymerase Chain Reaction', 'Reproducibility of Results'] | 25,170,848 | [['E01.370.225.998.293', 'E05.200.998.293', 'E05.393.290.573', 'E05.393.760.700.224', 'I01.198.780.937.375.500'], ['E05.393.332'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['E05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
[Effect of wheat bran fiber on vitamin status of weaning rats with alimentary polyhypovitaminosis]. | Effect of wheat bran on the vitamin status of rats adequately provided with vitamins or insufficiently supplied with vitamins has been investigated. 32 male Wistar weaning rats (initial body mass--49-67g) were randomly divided into 4 groups and fed with complete semi-synthetic diet, containing 100 or 20% of vitamin mix... | ['Animals', 'Avitaminosis', 'Dietary Fiber', 'Liver', 'Male', 'Rats', 'Vitamins'] | 25,059,066 | [['B01.050'], ['C18.654.521.500.133'], ['D09.301.416', 'G07.203.300.400', 'J02.500.400'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700'], ['D27.505.696.494.600', 'G07.203.300.681.500.600', 'J02.500.681.500.600']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cryptosporidium parvum infection in bovine neonates: dynamic clinical, parasitic and immunologic patterns. | Twenty-six experimentally infected calves were monitored daily for oocyst excretion. All began excreting oocysts 3-6 days p.i. Most calves (n = 23) excreted oocysts for 6-9 days, with a daily range from 4 x 10(2) to 4.15 x 10(7) oocysts g(-1) of faeces. Over half the calves excreted peak numbers of oocysts 6-8 days p.i... | ['Animals', 'Animals, Newborn', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Cattle', 'Cattle Diseases', 'Cryptosporidiosis', 'Cryptosporidium parvum', 'Diarrhea', 'Feces', 'Immunity, Cellular', 'Interferon-gamma', 'Interleukin-12', 'Lymphocyte Count', 'Male', 'RNA, Messenger', 'Transcription, Genetic'] | 9,504,334 | [['B01.050'], ['B01.050.050.282'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['C01.610.432.269', 'C01.610.701.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maternal perception of child overweight status and its association with weight-related parenting practices, their children's health behaviours and weight change in China. | OBJECTIVE: Childhood obesity has increased rapidly in China, but understanding is limited on how parents perceive their child's weight status and how this perception affects weight-related parenting practices. We examined maternal perception of her child's weight status and its association with demographics, subsequent... | ['Adolescent', 'Body Mass Index', 'Body Weight', 'Child', 'Child Behavior', 'China', 'Cross-Sectional Studies', 'Diet', 'Exercise', 'Female', 'Follow-Up Studies', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Longitudinal Studies', 'Male', 'Overweight', 'Parenting', 'Pediatric Obesity', 'Survey... | 28,583,222 | [['M01.060.057'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['M01.060.406'], ['F01.145.179'], ['Z01.252.474.164'], ['E05.318.372.500.875', 'N05.715.360... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Motor activation in patients with Pantothenate-Kinase Associated Neurodegeneration: a functional magnetic resonance imaging study. | BACKGROUND: In a variety of dystonias, functional magnetic resonance imaging has shown deviations of cortical and basal ganglia activations within the motor network, which might cause the movement disturbances. Because these investigations have never been performed in secondary dystonia due to Pantothenate-Kinase Assoc... | ['Adolescent', 'Brain Mapping', 'Case-Control Studies', 'Cerebellum', 'Female', 'Hand', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Motor Cortex', 'Movement', 'Oxygen', 'Pantothenate Kinase-Associated Neurodegeneration', 'Young Adult'] | 22,682,757 | [['M01.060.057'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A08.186.211.132.810.428.200'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['A... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Decrease of neocortical paired-pulse depression in GAERS and possible implication of gap junctions. | Thalamocortical slices are widely used to study thalamocortical relationships and absence epilepsy. However, it is still not known whether (1) intracortical synaptic transmission, in particular neocortical paired-pulse depression (PPD), is maintained in these slices and (2) whether PPD is altered in the Genetic Absence... | ['Animals', 'Anticonvulsants', 'Carbenoxolone', 'Cerebral Cortex', 'Disease Models, Animal', 'Electric Stimulation', 'Epilepsy, Absence', 'Gap Junctions', 'In Vitro Techniques', 'Neocortex', 'Quinidine', 'Rats, Wistar', 'Species Specificity', 'Synaptic Transmission'] | 25,450,143 | [['B01.050'], ['D27.505.954.427.080'], ['D02.455.849.919.530.444.250'], ['A08.186.211.200.885.287.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.723.402'], ['C10.228.140.490.375.260', 'C10.228.140.490.493.125'], ['A11.284.149.165.420.471'], ['E05.481'], ['A08.186.211.200.885.287.500.420'], ['D03.132.206.63... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mutation and evolution of microsatellite loci in Neurospora. | The patterns of mutation and evolution at 13 microsatellite loci were studied in the filamentous fungal genus Neurospora. First, a detailed investigation was performed on five microsatellite loci by sequencing each microsatellite, together with its nonrepetitive flanking regions, from a set of 147 individuals from eigh... | ['Base Sequence', 'Evolution, Molecular', 'Genetic Markers', 'Genetic Variation', 'Microsatellite Repeats', 'Molecular Sequence Data', 'Mutation', 'Neurospora'] | 15,579,682 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.045.250', 'G16.075.250'], ['D23.101.387', 'G05.695.450'], ['G05.365'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['L01.453.245.667'], ['G05.365.590'], ['B01.300.107.800.629']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Acute Ischemic Stroke in a Young Woman With No Known Risk Factors. | INTRODUCTION: We aim to highlight a potentially morbid consequence of foam-sclerotherapy for the treatment of varicose veins.CASE REPORT: We report a case of a 41-year-old woman with no significant medical history who presented to the emergency department with sudden onset of focal neurologic deficits. She had undergon... | ['Acute Disease', 'Adult', 'Brain Infarction', 'Brain Ischemia', 'Female', 'Foramen Ovale, Patent', 'Humans', 'Risk Factors', 'Sclerotherapy', 'Stroke', 'Varicose Veins'] | 29,677,415 | [['C23.550.291.125'], ['M01.060.116'], ['C10.228.140.300.150.477', 'C10.228.140.300.775.200', 'C14.907.253.092.477', 'C14.907.253.855.200', 'C23.550.513.355.250', 'C23.550.717.489.250'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C14.240.400.560.375.258', 'C14.280.400.560.375.258', 'C16.131.240.400.560.375.258'], ['... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Patient and physician gender concordance in preventive care in university primary care settings. | OBJECTIVE: To assess the quality of preventive care according to physician and patient gender in a country with universal health care coverage.METHODS: We assessed a retrospective cohort study of 1001 randomly selected patients aged 50-80 years followed over 2 years (2005-2006) in 4 Swiss university primary care settin... | ['Adult', 'Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Physician-Patient Relations', "Practice Patterns, Physicians'", 'Preventive Health Services', 'Primary Health Care', 'Retrospective Studies', 'Sex Factors', 'Switzerland'] | 25,117,521 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.829.401.650.675', 'N05.300.660.625'], ['N04.590.374.577', 'N05.300.625'], ['N02.421.726'], ['N04.590.233.727'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.71... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication. | During mitochondrial DNA (mtDNA) replication, DNA/RNA heteroduplex intermediates are formed. To understand how and why ribonucleotides are involved in mtDNA replication, we have studied the novel RNA-associated activities of human mitochondrial DNA polymerase (Pol gamma), including reverse transcription, RNA-directed 3... | ['Binding Sites', 'DNA', 'DNA Polymerase gamma', 'DNA Replication', 'DNA, Mitochondrial', 'DNA-Directed DNA Polymerase', 'Dose-Response Relationship, Drug', 'Genome', 'HIV Reverse Transcriptase', 'Humans', 'Kinetics', 'Models, Genetic', 'Protein Binding', 'RNA', 'RNA-Directed DNA Polymerase', 'Ribonucleotides', 'Time F... | 12,857,740 | [['G02.111.570.120'], ['D13.444.308'], ['D08.811.913.696.445.308.300.169', 'D12.776.575.280'], ['G02.111.225', 'G05.226'], ['D13.444.308.283.225'], ['D08.811.913.696.445.308.300'], ['G07.690.773.875', 'G07.690.936.500'], ['G05.360.340'], ['D08.811.913.696.445.308.300.750.187', 'D12.776.964.775.375.545.875', 'D12.776.96... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The efficacy of exercise in reducing depressive symptoms among cancer survivors: a meta-analysis. | INTRODUCTION: The purpose of this meta-analysis was to examine the efficacy of exercise to reduce depressive symptoms among cancer survivors. In addition, we examined the extent to which exercise dose and clinical characteristics of cancer survivors influence the relationship between exercise and reductions in depressi... | ['Adult', 'Aged', 'Depression', 'Exercise Therapy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Survivors', 'Treatment Outcome'] | 22,303,474 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.126.350'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['M01.860'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Carbohydrate structures of human tissue plasminogen activator expressed in Chinese hamster ovary cells. | Recombinant human tissue plasminogen activator (rt-PA), produced by expression in Chinese hamster ovary cells, is a fibrin-specific plasminogen activator which has been approved for clinical use in the treatment of myocardial infarction. In this study, the structures of the Asn-linked oligosaccharides of Chinese hamste... | ['Animals', 'Carbohydrate Conformation', 'Carbohydrate Sequence', 'Cell Line', 'Cricetinae', 'Cricetulus', 'Female', 'Glycoproteins', 'Glycosylation', 'Molecular Sequence Data', 'Oligosaccharides', 'Ovary', 'Recombinant Proteins', 'Tissue Plasminogen Activator'] | 2,503,511 | [['B01.050'], ['G02.111.570.820.235'], ['G02.111.570.160', 'L01.453.245.667.160'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['D09.400.430', 'D12.776.395'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['L01.453.245.667'], ['D09.698.629'], ['A05... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Antinociception induced in rats by intrathecal administration of antiserum against calcitonin gene-related peptide. | To determine whether or not endogenous calcitonin gene-related peptide (CGRP) participates in pain transmission in the spinal dorsal horn, effects of an intrathecal injection of anti-CGRP antiserum on nociceptive threshold in the paw-pressure test was examined in non-arthritic and adjuvant arthritic rats. An intratheca... | ['Animals', 'Arthritis', 'Calcitonin Gene-Related Peptide', 'Immune Sera', 'Injections, Spinal', 'Male', 'Neuropeptides', 'Pain', 'Rats', 'Rats, Inbred Strains', 'Sensory Thresholds'] | 3,264,395 | [['B01.050'], ['C05.550.114'], ['D12.644.400.097', 'D12.776.631.650.097'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], ['E02.319.267.530.580'], ['D12.644.400', 'D12.776.631.650'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Partial tears of the anterior cruciate ligament: diagnostic performance of isotropic three-dimensional fast spin echo (3D-FSE-Cube) MRI. | PURPOSE: To compare the performance of 3D-FSE-Cube MRI to arthroscopy, the reference test for the diagnosis of partial anterior cruciate ligament (ACL) tears.METHODS: A retrospective study was performed including all patients who underwent surgery for an ACL tear in our Sports Surgery Unit from January 2008 to December... | ['Adult', 'Anterior Cruciate Ligament Injuries', 'Arthroscopy', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Knee Injuries', 'Magnetic Resonance Imaging', 'Male', 'Retrospective Studies', 'Sensitivity and Specificity'] | 23,412,260 | [['M01.060.116'], ['C26.558.554.213'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['C26.558.554'], ['E01.370.350.825.500'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins. | Importance: There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of cases.Objective: To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction mo... | ['Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'CA-125 Antigen', 'Carcinoembryonic Antigen', 'Female', 'Humans', 'Keratin-19', 'Lung Neoplasms', 'Male', 'Mass Screening', 'Membrane Proteins', 'Middle Aged', 'Non-Smokers', 'Prospective Studies', 'Protein Precursors', 'Proteolipids', 'ROC Curve', 'Risk Assessment', '... | 30,003,238 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['D12.776.395.560.631.050', 'D23.050.285.050.225', 'D23.050.550.325.225', 'D23.101.140.075.225'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of aberrant observations on high-resolution linkage analysis outcomes. | Because of the availability of efficient, user-friendly computer analysis programs, the construction of multilocus human genetic maps has become commonplace. At the level of resolution at which most of these maps have been developed, the methods have proved to be robust. This may not be true in the construction of high... | ['Algorithms', 'Chromosome Mapping', 'Computer Simulation', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Male', 'Monte Carlo Method', 'Observer Variation', 'Reproducibility of Results', 'Statistics as Topic'] | 1,928,104 | [['G17.035', 'L01.224.050'], ['E05.393.183'], ['L01.224.160'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.31... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Spinal bone mineral density of normal and osteoporotic women in Korea. | In order to define osteoporosis on the basis of bone mineral measurements, one must define an acceptable normal range or fracture threshold. It is clear that the normal range cannot be compared between different ethnic groups. We have measured spinal bone mineral density (BMD) by dual photon absorptiometry in 277 women... | ['Adult', 'Age Factors', 'Aged', 'Asian Continental Ancestry Group', 'Bone Density', 'European Continental Ancestry Group', 'Female', 'Fractures, Bone', 'Humans', 'Korea', 'Menopause', 'Middle Aged', 'Osteoporosis', 'Spine'] | 1,524,726 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.686.508.200'], ['G11.427.100'], ['M01.686.508.400'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.557', 'Z01.586.407'], ['G08.686.157.500', 'G08.686.841.249.500'], ['M01.060.116.630'], ['C05.116.198.579',... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The site of action of 'chlormadinone acetate' (6-chloro-delta 6-dehydro-17 alpha-acetoxyprogesterone) in blocking ovulation in the mated rabbit. | 1. In a study of the site of action of a steroid in current use for contraceptive purposes (6-chloro-Delta(6)-dehydro-17alpha-acetoxyprogesterone; ;chlormadinone acetate'), the ovarian responses [secretion rate of 20alpha-hydroxypregn-4-en-3-one (20 alpha-OH), and the occurrence of ovulation] were observed in control o... | ['Anesthesia', 'Animals', 'Central Nervous System', 'Chlormadinone Acetate', 'Copulation', 'Estrus', 'Female', 'Hypothalamus', 'Injections, Intravenous', 'Luteinizing Hormone', 'Ovary', 'Ovulation', 'Pregnancy', 'Pregnanes', 'Rabbits', 'Steroids', 'Uterus'] | 4,172,067 | [['E03.155'], ['B01.050'], ['A08.186'], ['D04.210.500.745.432.144', 'D04.210.500.883.294'], ['F01.145.113.252.748.200'], ['G08.686.195.500'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.52... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Corticosterone stimulates hatching of late-term tree lizard embryos. | The regulation of hatching in oviparous animals is important for successful reproduction and survival, but is poorly understood. We unexpectedly found that RU-486, a progesterone and glucocorticoid antagonist, interferes with hatching of viable tree lizard (Urosaurus ornatus) embryos in a dose-dependent manner and hypo... | ['Animals', 'Corticosterone', 'Embryo, Nonmammalian', 'Female', 'Lizards', 'Male', 'Mifepristone', 'Oviparity', 'Ovum', 'Time Factors'] | 17,208,477 | [['B01.050'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['A13.350', 'A16.331'], ['B01.050.150.900.833.393'], ['D04.210.500.365.415.580'], ['G08.686.650'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['G01.910.857']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intracellular interleukin-1 receptor antagonist type 1 antagonizes the stimulatory effect of interleukin-1 alpha precursor on cell motility. | Interleukin (IL)-1alpha, a proinflammatory cytokine, is produced as a 33 kDa protein precursor (preIL-1alpha) which is cleaved to generate the 17 kDa C-terminal mature IL-1alpha (mIL-1alpha) and the 16kDa N-terminal IL-1alpha propiece (NIL-1alpha). The biological effect of IL-1alpha is regulated by the IL-1 receptor an... | ['Cell Line, Tumor', 'Cell Movement', 'Humans', 'Interleukin 1 Receptor Antagonist Protein', 'Interleukin-1', 'Intracellular Fluid', 'Protein Precursors', 'Receptors, Interleukin-1', 'Sialoglycoproteins', 'Transfection'] | 16,246,569 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.460', 'D12.776.467.374.460', 'D23.529.374.460'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131',... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of enzyme-linked immunosorbent assay for measurement of bovine serum and milk progesterone without extraction. | An enzyme immunoassay for progesterone, using horseradish peroxidase as the label, was adapted for direct measurement of progesterone in serum or milk. Values obtained by direct measurement are highly correlated with values measured in extracts and are usable for convenient, rapid, accurate monitoring of the reproducti... | ['Animals', 'Cattle', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Milk', 'Pregnancy', 'Pregnancy Tests', 'Progesterone'] | 3,711,410 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['G08.686.784.769'], ['E01.370.225.970', 'E0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
An in vitro compartmentalization-based method for the selection of bond-forming enzymes from large libraries. | We have developed a generalized in vitro compartmentalization-based bead display selection strategy that allows for the identification of enzymes that can perform ligation reactions. Although a number of methods have been developed to evolve such enzymes, many of them are limited in library size (10(6) -10(7) ), do not... | ['Aminoacyltransferases', 'Bacterial Proteins', 'Carbon-Nitrogen Ligases', 'Cloning, Molecular', 'Cysteine Endopeptidases', 'Escherichia coli', 'Escherichia coli Proteins', 'Kinetics', 'Models, Molecular', 'Peptide Library', 'Protein Binding', 'Protein Engineering', 'Repressor Proteins', 'Staphylococcus aureus'] | 26,806,853 | [['D08.811.913.050.200'], ['D12.776.097'], ['D08.811.464.259'], ['E05.393.220'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['D12.644.555', 'G02.111.570.060.620', 'G05.360.325.640']... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum. | Quinine and quinidine were over 100 times more active than 9-epiquinine and 9-epiquinidine against chloroquine-sensitive Plasmodium falciparum and over 10 times more active against chloroquine-resistant P. falciparum. Since the only structural difference between quinine, quinidine, 9-epiquinine, and 9-epiquinidine is t... | ['Animals', 'Antimalarials', 'Cinchona Alkaloids', 'Crystallography', 'Plasmodium falciparum', 'Stereoisomerism', 'Structure-Activity Relationship'] | 1,510,452 | [['B01.050'], ['D27.505.954.122.250.100.085'], ['D03.132.206'], ['E05.196.309', 'H01.181.529.240'], ['B01.043.075.380.611.561'], ['G02.607.445.682'], ['G02.111.830', 'G07.690.773.997']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Optimal scanning timing by use of multi-detector row computed tomography during thoracic aortography for depiction of arteries causing hemoptysis. | Scanning timing for multi-detector row computed tomography during thoracic aortography (MDCT-TA) was explored for depiction of arteries responsible for hemoptysis. The mean time (MT) from contrast medium (CM) injection to peak enhancement (PE) in the descending aorta at the level of the diaphragm on thoracic aortograph... | ['Aged', 'Aged, 80 and over', 'Aortography', 'Bronchial Arteries', 'Bronchiectasis', 'Contrast Media', 'Embolization, Therapeutic', 'Female', 'Hemoptysis', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Prospective Studies', 'Pulmonary Aspergillosis', 'Tomography, X-Ray Computed', 'Tuberculosis, Pulmonary'] | 24,297,509 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.700.060.070', 'E01.370.370.050.070'], ['A07.015.114.158'], ['C08.127.384'], ['D27.505.259.500', 'D27.720.259'], ['E02.520.360', 'E02.926.500'], ['C08.381.348', 'C23.550.414.896', 'C23.888.852.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Functional ability and the need for care: issues for measurement research. | Measuring the prevalence of functional disability among older people is extremely important. The number of older people is projected to increase in both the developed and the developing countries. The incidence and prevalence of functional disability are high among older people, and they are higher at older ages. Many ... | ['Activities of Daily Living', 'Age Factors', 'Aged', 'Female', 'Frail Elderly', 'Geriatric Assessment', 'Humans', 'Incidence', 'Male', 'Prevalence', 'Research', 'United States'] | 1,844,680 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.540'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['B01.050.150.900.649.313.9... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Evaluating the primary-to-specialist referral system for elective hip and knee arthroplasty. | RATIONALE, AIMS AND OBJECTIVES: Persistently long waiting times for hip and knee total joint arthroplasty (TJA) specialist consultations have been identified as a problem. This study described referral processes and practices, and their impact on the waiting time from referral to consultation for TJA.METHODS: A mixed-m... | ['Alberta', 'Arthroplasty, Replacement, Hip', 'Arthroplasty, Replacement, Knee', 'Elective Surgical Procedures', 'Health Services Accessibility', 'Humans', 'Orthopedics', 'Physicians, Primary Care', 'Referral and Consultation', 'Retrospective Studies', 'Time Factors', 'Waiting Lists'] | 24,004,242 | [['Z01.107.567.176.064'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['E04.249'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.810.494'], ['M01.526.485.810.800', 'N02.360.810.795'... | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Tissue-Specific Accumulation of Sulfur Compounds and Saponins in Different Parts of Garlic Cloves from Purple and White Ecotypes. | This study set out to determine the distribution of sulfur compounds and saponin metabolites in different parts of garlic cloves. Three fractions from purple and white garlic ecotypes were obtained: the tunic (SS), internal (IS) and external (ES) parts of the clove. Liquid Chromatography coupled to High Resolution Mass... | ['Chromatography, High Pressure Liquid', 'Cluster Analysis', 'Computational Biology', 'Ecotype', 'Garlic', 'Mass Spectrometry', 'Organ Specificity', 'Saponins', 'Sulfur Compounds'] | 28,825,644 | [['E05.196.181.400.300'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['H01.158.273.180', 'L01.313.124'], ['G05.695.200', 'G16.500.275.157.049.230', 'N06.230.124.049.230'], ['B01.650.940.800.575.912.250.618.100.050.060.300'], ['E05.196.566'], ['G07.650'], ['D09.408.782'], ['D01.875', 'D02.886']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected? | The realisation that pindolol may accelerate the effects of some antidepressant drugs in clinical trials has added extra impetus to the search for faster acting antidepressants. Currently, no animal model of depression can identify potential faster acting antidepressant drugs or drug combinations. In this study, we inv... | ['8-Hydroxy-2-(di-n-propylamino)tetralin', 'Adrenergic beta-Antagonists', 'Animals', 'Antidepressive Agents', 'Depression', 'Disease Models, Animal', 'Drug Therapy, Combination', 'Exploratory Behavior', 'Hypothermia', 'Male', 'Olfactory Bulb', 'Paroxetine', 'Pindolol', 'Rats', 'Rats, Sprague-Dawley', 'Serotonin Recepto... | 9,718,263 | [['D02.455.426.559.847.638.960.400', 'D04.615.638.960.400'], ['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['B01.050'], ['D27.505.954.427.700.122'], ['F01.145.126.350'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.319.310'], ['F01.145.387', 'F01.658.370'], ['C23.888.119.565'], ['A08.186.211.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Past-year relational victimization is associated with a blunted neural response to rewards in emerging adults. | Anhedonia is associated with multiple forms of psychopathology, yet relatively, little is known about how anhedonia develops. Emerging evidence suggests that anhedonia is the result of interactions between life stress and the brain's reward systems, and that social stress, in particular, may drive these processes. One ... | ['Adolescent', 'Adult', 'Anhedonia', 'Brain', 'Bullying', 'Crime Victims', 'Evoked Potentials', 'Female', 'Humans', 'Male', 'Peer Group', 'Reward', 'Self Concept', 'Stress, Psychological', 'Young Adult'] | 30,307,568 | [['M01.060.057'], ['M01.060.116'], ['C10.597.606.057', 'C23.888.592.604.039', 'F01.700.039'], ['A08.186.211'], ['F01.145.126.125.550', 'F01.145.813.213.500', 'I01.880.735.070'], ['M01.135'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.316.483'], ['F02.463.425.770.8... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Evolution within the fungal genus Verticillium is characterized by chromosomal rearrangement and gene loss. | The fungal genus Verticillium contains ten species, some of which are notorious plant pathogens causing vascular wilt diseases in host plants, while others are known as saprophytes and opportunistic plant pathogens. Whereas the genome of V. dahliae, the most notorious plant pathogen of the genus, has been well characte... | ['Base Sequence', 'DNA, Bacterial', 'Evolution, Molecular', 'Genome, Bacterial', 'Plant Diseases', 'Plants', 'Verticillium', 'Whole Genome Sequencing'] | 29,282,842 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.212'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.358.207'], ['G15.610'], ['B01.650'], ['B01.300.381.950'], ['E05.393.760.700.825']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Esophagus sparing with IMRT in lung tumor irradiation: an EUD-based optimization technique. | PURPOSE: The aim of this study was to evaluate (1) the use of generalized equivalent uniform dose (gEUD) to optimize dose escalation of lung tumors when the esophagus overlaps the planning target volume (PTV) and (2) the potential benefit of further dose escalation in only the part of the PTV that does not overlap the ... | ['Carcinoma, Non-Small-Cell Lung', 'Esophagus', 'Humans', 'Lung Neoplasms', 'Radiography', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Conformal'] | 16,111,587 | [['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['A03.556.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['E01.370.350.700'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['E02.815.635.700... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Protective effect of a new antioxidant on acute hepatotoxicity caused by morpholine plus nitrite in rats. | Bis(2,2-dimethyl-4-methane sulphonic acid sodium salt-1,2-dihydroquinoline)-6,6'-methane (MTDQ-DA), a new, non-toxic, water soluble antioxidant, is shown to inhibit liver necrosis induced in rats by N-nitrosomorpholine (N-MOR), itself formed in vivo following the administration simultaneously of morphine (MOR) and sodi... | ['Animals', 'Antioxidants', 'Liver', 'Male', 'Morpholines', 'Necrosis', 'Nitrites', 'Nitrosamines', 'Quinolines', 'Rats', 'Sodium Nitrite'] | 7,222,103 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A03.620'], ['D03.383.533.640'], ['C23.550.717'], ['D01.248.497.158.635', 'D01.625.600.600', 'D02.633'], ['D02.654.442'], ['D03.633.100.810'], ['B01.050.150.900.649.313.992.635.505.700'], ['D01.625.600.600.800', 'D01.857.775']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bilinear dynamical systems. | In this paper, we propose the use of bilinear dynamical systems (BDS)s for model-based deconvolution of fMRI time-series. The importance of this work lies in being able to deconvolve haemodynamic time-series, in an informed way, to disclose the underlying neuronal activity. Being able to estimate neuronal responses in ... | ['Algorithms', 'Brain', 'Brain Mapping', 'Computer Simulation', 'Data Interpretation, Statistical', 'Humans', 'Linear Models', 'Magnetic Resonance Imaging', 'Models, Neurological', 'Neurons', 'Stochastic Processes', 'Time Factors'] | 16,087,442 | [['G17.035', 'L01.224.050'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['L01.224.160'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients. | The aim of this study was to determine whether C34T, a common polymorphism of the adenosine monophosphate deaminase 1 gene (AMPD1), is associated with essential hypertension (EH). We hypothesize that C34T is associated with the development of EH. A case-control design was used for this study. The DNA was extracted usin... | ['AMP Deaminase', 'Aged', 'Case-Control Studies', 'Female', 'Heterozygote', 'Humans', 'Hypertension', 'Malaysia', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide'] | 27,323,204 | [['D08.811.277.151.653.060'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G05.380.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['Z01.252.145.487'], ['M01.060.116.630'], ['G05.365.795.598']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Efficacy and influence factors of icotinib hydrochloride in treating advanced non-small cell lung cancer. | OBJECTIVE: To evaluate the efficacy and safety of icotinib hydrochloride in the treatment of patients with advanced non-small cell lung cancer (NSCLC) and discuss the influence factors on efficacy.PATIENTS AND METHODS: 120 treatment-experienced patients confirmed by pathology or cytology with stage III B-IV non-small c... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'Crown Ethers', 'Disease-Free Survival', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Mutation', 'Quinazolines'] | 28,165,562 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['D02.355.291.308', 'D04.345.051.500', 'D04.345.241.308'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.57... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of routine double contrast views of the anterior wall of the stomach. | Since June 1974, we have performed over 1,500 consecutive double contrast upper gastrointestinal examinations. The double contrast study of the anterior wall has been a useful adjunct to conventional mucosal relief and dosed compression studies. Nevertheless, the low diagnostic yield of the anterior wall examination do... | ['Contrast Media', 'Fluoroscopy', 'Gastric Mucosa', 'Humans', 'Radiographic Image Enhancement', 'Stomach', 'Stomach Neoplasms', 'Stomach Ulcer', 'Technology, Radiologic'] | 179,373 | [['D27.505.259.500', 'D27.720.259'], ['E01.370.350.700.225'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['A03.556.875.875'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.40... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Rationale and design of the school-based SI! Program to face obesity and promote health among Spanish adolescents: A cluster-randomized controlled trial. | Unhealthy habits in adolescents are increasing at an alarming rate. The school offers a promising environment in which to implement effective preventive strategies to improve adolescents' lifestyle behaviors. The SI! Program is a multilevel multicomponent school-based health-promotion intervention aimed at all stages o... | ['Adolescent', 'Body Mass Index', 'Child', 'Curriculum', 'Exercise', 'Feeding Behavior', 'Female', 'Health Behavior', 'Health Education', 'Humans', 'Life Style', 'Male', 'Obesity', 'School Health Services', 'Schools', 'Spain'] | 31,277,052 | [['M01.060.057'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.060.406'], ['I02.158'], ['G11.427.410.698.277', 'I03.350'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F01.145.488'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'G... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Ballantyne syndrome: a case report. | Ballantyne syndrome (also called mirror syndrome or triple edema) describes the unusual association of fetal and placental hydrops with maternal preeclampsia. This is a case report illustrating a 37-year-old patient who was referred to our clinics at 28 weeks of gestation (wg) because of fetal hydrothorax. On examinati... | ['Adult', 'Female', 'Humans', 'Hydrops Fetalis', 'Pre-Eclampsia', 'Pregnancy', 'Syndrome', 'Ultrasonography, Prenatal'] | 16,354,984 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.277.060.480', 'C15.378.295.480', 'C15.378.420.826.100.350', 'C16.300.060.480', 'C16.320.365.826.100.350', 'C20.306.480', 'C23.888.277.395'], ['C13.703.395.249'], ['G08.686.784.769'], ['C23.550.288.500'], ['E01.370.350.850.865', 'E01.370.378.63... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Consultation for employees about cancer: the role of industrial physicians]. | At present, one-third of people die of cancer and the number is still increasing in Japan. Recently, the discovery of new drugs and the development of medical oncology promote outpatient treatment for cancer patients. In the near future, the working style by employees receiving cancer chemotherapy is expected to increa... | ['Anxiety', 'Counseling', 'Health Education', 'Humans', 'Neoplasms', 'Occupational Health Services', 'Occupational Medicine', "Physician's Role", 'Referral and Consultation', 'Workplace'] | 17,380,732 | [['F01.470.132'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['N02.421.143.740'], ['H02.403.720.750.510'], ['F01.829.316.616.625.600'], ['N04.452.758.849'], ['N01.824.245.925', 'N04.452.677.975']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Gaucher disease (type III): intellectual profile. | In 20 patients with Gaucher disease type III (Norrbottnian variant), long-term intellectual prognoses were analyzed on the basis of psychometric tests which were performed on an average of five tests per patient. Intellectual delay was not found to be characteristic of the early stages of the disease. Slow regression o... | ['Adolescent', 'Child', 'Child, Preschool', 'Follow-Up Studies', 'Gaucher Disease', 'Humans', 'Intelligence', 'Splenectomy'] | 3,508,057 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C10.228.140.163.100.435.825.400', 'C16.320.565.189.435.825.400', 'C16.320.565.398.641.803.441', 'C16.320.565.595.554.825.400', 'C18.452.132.100.435.825.400', 'C18.452.584.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hepatic stellate cells in hepatitis C patients: relationship with the development of interstitial fibrosis in renal allografts. | The aim of this study was twofold; first, we evaluated the influence of hepatitis C virus (HCV) and iron deposition on hepatic stellate cells (HSCs), and second, we determined the influence of HSCs on the development of interstitial fibrosis (IF) in renal allografts. Thirty chronic HCV positive patients bearing renal a... | ['Adult', 'Biopsy', 'Hepatic Stellate Cells', 'Hepatitis C, Chronic', 'Humans', 'Immunosuppressive Agents', 'Interferons', 'Iron', 'Kidney Transplantation', 'Kidney Tubules', 'Liver', 'Middle Aged', 'Transforming Growth Factor beta', 'Transplantation, Homologous', 'Tumor Necrosis Factor-alpha'] | 19,765,451 | [['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A11.561'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.900.649... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study. | BACKGROUND: The prognostic significance of total kidney volume (TKV) in subjects with type 2 diabetes mellitus (T2DM) is unknown.METHODS: One hundred and seventy unrelated Caucasians with T2DM underwent multidetector-row computed tomography of the neck, chest, and abdomen to measure calcified plaque in the coronary art... | ['Aged', 'Albuminuria', 'Aorta, Abdominal', 'Atherosclerosis', 'Blood Pressure', 'Diabetes Mellitus, Type 2', 'Diabetic Angiopathies', 'Diabetic Neuropathies', 'Female', 'Humans', 'Kidney', 'Male', 'Middle Aged', 'Organ Size', 'Tomography, X-Ray Computed'] | 18,057,869 | [['M01.060.116.100'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['A07.015.114.056.205'], ['C14.907.137.126.307'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C18.452.394.750.149', 'C19.246.300'], ['C14.907.320', 'C19.246.099.500'], ['C10.668.829.300', 'C19.246.099.937'], ['B01.050.150... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Delayed Introduction of Everolimus in De Novo Renal Transplanted Patients: A Single-Center Experience. | INTRODUCTION: Immunosuppressive protocols containing everolimus (EVR) preserve good renal function in kidney transplantation (KT), although they are often complicated by several adverse events. We have evaluated the efficacy and safety of a protocol with late (1 month after KT) EVR introduction.MATERIAL AND METHODS: Th... | ['Adult', 'Aged', 'Dose-Response Relationship, Drug', 'Everolimus', 'Female', 'Graft Rejection', 'Graft Survival', 'Humans', 'Immunosuppressive Agents', 'Kidney Function Tests', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Postoperative Complications', 'Tacrolimus', 'Time Factors', 'Treatment Outcome'] | 27,109,947 | [['M01.060.116'], ['M01.060.116.100'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.540.505.760.500'], ['G12.875.545.328'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E01.370.390.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['C... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intramuscular and oral disposition of enrofloxacin in African grey parrots following single and multiple doses. | The intramuscular (IM) and oral (PO) disposition of enrofloxacin, a new fluoroquinolone antimicrobial drug, were evaluated in African grey parrots. Peak enrofloxacin concentration, mean (+/- SEM), at 1 h following a 15-mg/kg IM dose was 3.87 (+/- 0.27) micrograms/ml and declined with a mean residence time of 3.05 h. Pe... | ['Administration, Oral', 'Animals', 'Anti-Infective Agents', 'Biological Availability', 'Ciprofloxacin', 'Dose-Response Relationship, Drug', 'Enrofloxacin', 'Fluoroquinolones', 'Half-Life', 'Injections, Intramuscular', 'Parrots', 'Quinolones'] | 1,663,561 | [['E02.319.267.100'], ['B01.050'], ['D27.505.954.122'], ['G03.787.151', 'G07.690.725.129'], ['D03.633.100.810.835.322.186'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.633.100.810.835.322.304'], ['D03.633.100.810.835.322'], ['G01.910.405'], ['E02.319.267.530.460'], ['B01.050.150.900.248.710.672'], ['D03.633.100.810.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Interaction of H1 lysine-rich histone fragments with DNA]. | The interaction of H1 histone octapeptide 15--22 amino acid sequence fragment and shorter peptides with DNA has been investigated in water low ionic strength solutions (0.01 M NaCl) by means of UV-spectroscopy, circular dichroism (CD), equilibrium dialysis and thermal denaturation. Decreasing of the DNA absorbtion band... | ['Amino Acid Sequence', 'Animals', 'DNA', 'Histones', 'Kinetics', 'Lysine', 'Male', 'Nucleic Acid Conformation', 'Peptide Fragments', 'Salmon', 'Spectrophotometry, Ultraviolet', 'Spermatozoa'] | 6,808,352 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D13.444.308'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['G01.374.661', 'G02.111.490'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['G02.111.570.820.486', 'G05.360.580'], ['D12.644.541'], ['B01.050.150.900.493.817.750.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ventral Approach to the Middle Hepatic Vein During Laparoscopic Hemihepatectomy. | BACKGROUND: The caudal approach constitutes a conceptual change in laparoscopic hepatectomy.1-4 The middle hepatic vein (MHV) located in the midplane of the liver serves as a landmark during hemihepatectomy.5 However, it is difficult to expose the MHV from its peripheral branches toward the main root via the caudal app... | ['Hepatectomy', 'Hepatic Veins', 'Humans', 'Laparoscopy', 'Length of Stay', 'Liver Neoplasms', 'Operative Time', 'Postoperative Complications', 'Prognosis'] | 30,353,394 | [['E04.210.556'], ['A07.015.908.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E02.760.400.480', 'N02.421.585.400.480'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['C23.550.767'], ['E01.789']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Neonatal herpes simplex encephalitis: correlation of clinical and CT findings. | Review of 31 computed tomographic (CT) scans in 15 neonates with herpes simplex encephalitis (HSE) type 2 revealed the most characteristic early findings to be patchy and widespread areas of low attenuation, primarily in white matter, with minimal contrast material enhancement in a meningeal pattern. The low-attenuatio... | ['Encephalitis', 'Female', 'Herpes Simplex', 'Humans', 'Infant, Newborn', 'Male', 'Tomography, X-Ray Computed'] | 3,809,499 | [['C10.228.140.430'], ['C01.925.256.466.382', 'C01.925.825.320', 'C17.800.838.790.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The rs3761548 FOXP3 variant is associated with multiple sclerosis and transforming growth factor â1 levels in female patients. | OBJECTIVE: The aim of this study was to evaluate the association between rs3761548 FOXP3 (-3279 C > A) variant and multiple sclerosis (MS), disability, disability progression, as well as transforming growth factor (TGF)-â1 and interleukin (IL)-10 plasma levels in MS patients.METHODS AND SUBJECTS: The study included 170... | ['Adult', 'Brazil', 'Female', 'Forkhead Transcription Factors', 'Genetic Variation', 'Genotype', 'Humans', 'Interleukin-10', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Sex Characteristics', 'Transforming Growth Factor beta1'] | 31,414,141 | [['M01.060.116'], ['Z01.107.757.176'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['G05.365'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.50... | ['Named Groups [M]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Moderate zinc-iron deprivation influences behavior but not growth in adolescent rhesus monkeys. | Primate species demonstrate a prolonged period of development before reproductive maturity that includes distinctive periods of rapid growth in the late fetal, late infancy and early adolescent stages. Rhesus monkeys resemble humans in this discontinuous pattern of growth and also in its relationship to brain developme... | ['Animals', 'Behavior, Animal', 'Body Weight', 'Diet', 'Female', 'Growth', 'Hematocrit', 'Iron', 'Macaca mulatta', 'Zinc'] | 10,721,905 | [['B01.050'], ['F01.145.113'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.203.650.240'], ['G07.345.249'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['B01.050.15... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Rapidly deteriorated lobar intracerebral hemorrhages: possible association of varicella zoster virus-vasculopathy]. | A 75-year-old man having dementia and lifestyle related diseases developed a lobar intracerebral hemorrhage (LICH) in the left parietal and a small cerebellar infarction in the left occipital lobe. Many micro bleeds (MB) due to cerebral amyloid angiopathy (CAA) in the subcortical areas and multiple vascular stenosis we... | ['Aged', 'Cerebral Amyloid Angiopathy', 'Cerebral Hemorrhage', 'Disease Progression', 'Fatal Outcome', 'Frontal Lobe', 'Herpes Zoster', 'Humans', 'Magnetic Resonance Angiography', 'Magnetic Resonance Imaging', 'Male', 'Parietal Lobe', 'Recurrence', 'Vasculitis, Central Nervous System'] | 29,607,919 | [['M01.060.116.100'], ['C10.228.140.300.510.200.200', 'C14.907.253.560.200.200', 'C18.452.845.500.100'], ['C10.228.140.300.535.200', 'C14.907.253.573.200', 'C23.550.414.913.100'], ['C23.550.291.656'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['A08... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Neurotolerability of contrast agents in rats with brain ischemia induced by transient middle cerebral artery occlusion: EEG evaluation. | RATIONALE AND OBJECTIVES: Because contrast agent (CA) formulations are injected intravenously to patients who may have a disrupted blood-brain barrier, their neurotolerability should be tested by using appropriate animal models. In the present study, a model of rat brain ischemia evaluated in terms of the electroenceph... | ['Animals', 'Arterial Occlusive Diseases', 'Brain', 'Brain Ischemia', 'Cerebral Arterial Diseases', 'Contrast Media', 'Electroencephalography', 'Gadolinium DTPA', 'Male', 'Meglumine', 'Middle Cerebral Artery', 'Organometallic Compounds', 'Rats', 'Rats, Sprague-Dawley'] | 11,176,255 | [['B01.050'], ['C14.907.137'], ['A08.186.211'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C10.228.140.300.510.200', 'C14.907.253.560.200'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.376.300', 'E01.370.405.245'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['D02.033.800.813.550', 'D09.067.... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dislocation of the shoulder with fracture of the ipsilateral shaft of the humerus. | Three cases of dislocation of the shoulder and ipsilateral fracture of the shaft of the humerus are reported. The literature is reviewed. It is suggested that X-ray films should be taken of the shoulder and elbow in all patients with fractures of the shaft of the humerus. | ['Adult', 'Female', 'Humans', 'Humeral Fractures', 'Male', 'Middle Aged', 'Radiography', 'Shoulder Dislocation'] | 4,008,003 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.088.390', 'C26.404.500'], ['M01.060.116.630'], ['E01.370.350.700'], ['C05.550.518.750', 'C26.289.750', 'C26.803.125']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Percutaneous video-assisted necrosectomy for infected pancreatic necrosis. | AIMS OF THE STUDY: Percutaneous drainage of infected pancreatic necrosis is not always efficient and morbidity is high with open necrosectomy techniques. Minimally-invasive procedures have been developed to reduce this morbidity. We report our early experience with percutaneous video-assisted necrosectomy.METHODS: Amon... | ['Adult', 'Aged', 'Drainage', 'Female', 'Humans', 'Male', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Pancreatitis, Acute Necrotizing', 'Retrospective Studies', 'Treatment Outcome', 'Video-Assisted Surgery'] | 15,523,223 | [['M01.060.116'], ['M01.060.116.100'], ['E02.309', 'E04.237'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.502'], ['C06.689.750.650'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Particle repositioning maneuver versus Brandt-Daroff exercise for treatment of unilateral idiopathic BPPV of the posterior semicircular canal: a randomized prospective clinical trial with short- and long-term outcome. | OBJECTIVE: To compare the outcome and probability of recurrence in a series of patients with unilateral idiopathic benign paroxysmal positional vertigo of the posterior canal (PC-BPPV) that were randomly treated by Brandt-Daroff exercise (B-D exercise) or by particle repositioning maneuver (PRM).STUDY DESIGN: Randomize... | ['Adult', 'Aged', 'Aged, 80 and over', 'Benign Paroxysmal Positional Vertigo', 'Cohort Studies', 'Eye Movements', 'Female', 'Follow-Up Studies', 'Humans', 'Kaplan-Meier Estimate', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neurologic Examination', 'Physical Therapy Modalities', 'Prospective Studies', 'Recurr... | 22,935,812 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C09.218.568.900.883.500', 'C10.597.951.500', 'C23.888.592.958.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G11.427.410.140', 'G14.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.45... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Skydiving: The audiological perspective. | BACKGROUND: Skydiving is a popular recreational sport for the young and old. There is minimal research pertaining to skydiving and its relation to the audiological system. The risks of skydiving in relation to the auditory system should be explored further. Aims: The main aim of this study was to explore the relations... | ['Acoustic Impedance Tests', 'Adolescent', 'Adult', 'Athletic Injuries', 'Audiology', 'Aviation', 'Ear Diseases', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Qualitative Research', 'Risk', 'South Africa', 'Sports', 'Young Adult'] | 29,943,588 | [['E01.370.382.375.050'], ['M01.060.057'], ['M01.060.116'], ['C26.115'], ['H02.010.150'], ['J01.937.285'], ['C09.218'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.241.850'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anthropol... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Organ and tissue donation-related attitudes, education and practices of emergency department clinicians in Australia. | OBJECTIVE: The ED is emerging as a priority for efforts to improve rates of organ and tissue donation (OTD) in Australia, but little is known of ED clinicians' attitudes, education or practices in the area. We aimed to determine the attitudes and OTD-related educational background and practices of Australian ED clinici... | ['Adult', 'Australia', 'Cross-Sectional Studies', 'Education, Medical, Continuing', 'Emergency Medicine', 'Emergency Service, Hospital', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Medical Staff, Hospital', 'Middle Aged', 'Surveys and Questionnaires', 'Tissue and Organ Procurement'] | 22,672,164 | [['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I02.358.212.350', 'I02.358.399.250'], ['H02.403.250'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.9... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Antidepressant-like effects of ecstasy in subjects with a predisposition to depression. | INTRODUCTION: Positive effects of ecstasy on mood and self-esteem due to increased synaptic serotonin levels may indicate a potential antidepressant-like action. This effect may be more prominent in subjects with a pre-existing mood disturbance who may use ecstasy more frequently as a 'self-medication'. This study comp... | ['Affect', 'Case-Control Studies', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'N-Methyl-3,4-methylenedioxyamphetamine', 'Serotonin Agents', 'Surveys and Questionnaires', 'Treatment Outcome', 'Young Adult'] | 22,704,044 | [['F01.470.047'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.092.471.683.152.670'], ['D27.505.519.625.850', 'D27.505.696.577.850'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E01.789.800... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increasing longevity by decreasing sympathetic stress--early beta receptor blockade pharmacotherapy. | Consideration regarding human aging and sympathetic nervous system activity suggests that old age represents a hyperadrenergic state. With advancing age the sympathetically mediated stress on the body, specifically the cardiovascular system, may outweigh the benefits an intact sympathetic nervous system conveys for sho... | ['Adrenergic beta-Antagonists', 'Aging', 'Autonomic Nervous System Diseases', 'Cardiovascular Diseases', 'Humans', 'Longevity', 'Stress, Physiological', 'Sympathetic Nervous System'] | 15,082,101 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['G07.345.124'], ['C10.177'], ['C14'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.345.124.519', 'G07.540'], ['G07.775'], ['A08.800.050.800']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Opposing effects of aspirin and anticoagulants on morbidity and mortality in patients with upper gastrointestinal bleeding. | OBJECTIVE: We aimed to determine the effect of antithrombotics on in-hospital mortality and morbidity in patients with peptic ulcer disease-related upper gastrointestinal bleeding (PUD-related UGIB).METHODS: The study cohort was retrospectively selected from a tertiary center database of patients with PUD-related UGIB,... | ['Aged', 'Aged, 80 and over', 'Anti-Inflammatory Agents, Non-Steroidal', 'Anticoagulants', 'Aspirin', 'Female', 'Hospital Mortality', 'Humans', 'Lebanon', 'Length of Stay', 'Male', 'Middle Aged', 'Morbidity', 'Peptic Ulcer Hemorrhage', 'Platelet Aggregation Inhibitors', 'Recurrence', 'Retrospective Studies'] | 24,593,260 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D27.505.954.502.119'], ['D02.455.426.559.389.657.410.595.176'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.050.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Comparison of artificial neural networks with logistic regression in prediction of in-hospital death after percutaneous transluminal coronary angioplasty. | OBJECTIVES: Our objective was to compare artificial neural networks (ANNs) with logistic regression for prediction of in-hospital death after percutaneous transluminal coronary angioplasty and to assess the impact of guiding initial ANN variable selection with univariate analysis.BACKGROUND: ANNs can detect complex pat... | ['Aged', 'Angioplasty, Balloon, Coronary', 'Databases, Factual', 'Female', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Neural Networks, Computer', 'Predictive Value of Tests', 'Prognosis', 'Risk Assessment'] | 10,966,555 | [['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Comparison of family caregivers. Stroke survivors vs. person with Alzheimer's disease. | The purpose of this study was to compare family caregivers of person with dementia and caregivers of stroke survivors with similar levels of caregiving responsibilities. The design was descriptive and included characteristics of care recipients, caregivers, and care situations. Caregivers of individuals with dementia r... | ['Activities of Daily Living', 'Adaptation, Psychological', 'Alzheimer Disease', 'Caregivers', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Stroke', 'Stroke Rehabilitation', 'United States'] | 12,640,864 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['F01.058'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system. | Streptomycete antibiotic synthesis is coupled to morphological differentiation such that antibiotics are produced as a colony sporulates. Streptomyces coelicolor produces several structurally and genetically distinct antibiotics. The S. coelicolor absA locus was defined by four UV-induced mutations that globally blocke... | ['Alleles', 'Amino Acid Sequence', 'Anthraquinones', 'Anti-Bacterial Agents', 'Base Sequence', 'Chromosome Mapping', 'Cloning, Molecular', 'Genes, Bacterial', 'Molecular Sequence Data', 'Mutation', 'Signal Transduction', 'Streptomyces'] | 8,655,502 | [['G05.360.340.024.340.030'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D02.455.426.559.847.117.159', 'D02.806.100', 'D04.615.117.159'], ['D27.505.954.122.085'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['E05.393.220'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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