Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Two-stage models for the analysis of cancer screening data. | Methods are proposed for the analysis of the natural history of disease from screening data when it cannot be assumed that untreated preclinical disease always progresses to clinical disease. The methodology is based on a two-stage model for preclinical disease in which stage 1 lesions may or may not progress to stage ... | ['Biometry', 'Female', 'Humans', 'Mass Screening', 'Models, Theoretical', 'Neoplasms', 'Prospective Studies', 'Scotland', 'Uterine Cervical Neoplasms'] | 3,663,822 | [['E05.318.740.225', 'N06.850.505.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['E05.599'], ['C04'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Serum 1,25 dihydroxyvitamin D and osteocalcin concentrations in thalassaemia major. | In view of the claim that low 25-hydroxyvitamin D (25-OHD) concentrations may contribute to the pathogenesis of bone disease in patients with beta thalassaemia major and iron overload, we have assessed the concentrations of 25-OHD, 1 alpha,25 dihydroxyvitamin D (1 alpha,25(OH)2D), parathyroid hormone, and osteocalcin i... | ['Adolescent', 'Adult', 'Bone and Bones', 'Calcifediol', 'Calcitriol', 'Calcium', 'Calcium-Binding Proteins', 'Female', 'Humans', 'Male', 'Osteocalcin', 'Parathyroid Hormone', 'Seasons', 'Thalassemia'] | 3,496,858 | [['M01.060.057'], ['M01.060.116'], ['A02.835.232', 'A10.165.265'], ['D04.210.500.247.222.159.478.250', 'D04.210.500.247.808.146.478.250', 'D04.210.500.812.768.196.478.250', 'D10.570.938.146.478.250'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', '... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of image quality between a narrow caliber transesophageal echocardiographic probe and the standard size probe during intraoperative evaluation. | BACKGROUND: Transesophageal echocardiography (TEE) has become an integral part of the evaluation and monitoring of patients during cardiac operation. Until recently, the smallest TEE probe with multiplane imaging measured 13 mm in diameter. This size is now standard for adult TEE probes. Recently, a new TEE probe has b... | ['Aged', 'Cardiac Surgical Procedures', 'Echocardiography, Transesophageal', 'Equipment Design', 'Female', 'Humans', 'Intraoperative Care', 'Male', 'Middle Aged', 'Monitoring, Physiologic'] | 15,452,470 | [['M01.060.116.100'], ['E04.100.376', 'E04.928.220'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.400'], ['M01.060.116.630'], ['E01.370.520']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier. | Statins, 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, are frequently used for the treatment of hypercholesterolemia. The present study aimed to examine the involvement of organic anion transporters in the efflux transport of pravastatin and pitavastatin across the blood-brain barrier (BBB). Transport studies us... | ['Animals', 'Blood-Brain Barrier', 'Brain', 'Carrier Proteins', 'DNA, Complementary', 'Digoxin', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'In Vitro Techniques', 'Kinetics', 'Male', 'Microinjections', 'Organic Anion Transporters, Sodium-Independent', 'Pravastatin', 'Quinolines', 'Rats', 'Rats, Sprague-Dawley', ... | 15,292,460 | [['B01.050'], ['A07.035', 'A08.186.211.035'], ['A08.186.211'], ['D12.776.157'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D04.210.500.155.580.130.500.436', 'D04.210.500.155.580.130.688', 'D09.408.180.261.436'], ['D27.505.519.186.071.202.370', 'D27.505.519.389.370', 'D27.505.954.55... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Primary hepatic pheochromocytoma? | We report a case of a single intrahepatic pheochromocytoma in the absence of an adrenal lesion and no evidence of metastatic disease. The patient had strong clinical and biochemical evidence of a pheochromocytoma. A CT scan was abnormal but nondiagnostic for pheochromocytoma. An 123I-metaiodobenzyl guanidine (MIBG) sca... | ['Adult', 'Female', 'Humans', 'Liver Neoplasms', 'Magnetic Resonance Imaging', 'Pheochromocytoma'] | 8,896,659 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E01.370.350.825.500'], ['C04.557.465.625.650.700.725', 'C04.557.580.625.650.700.725']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
X monosomy in a virilized female cat. | An infertile Siamese female cat was subjected for clinical, histological, cytogenetic and molecular studies due to ambiguous external genitalia (vulva, vagina, rudimentary penis and scrotum-like structure) and masculine behaviour. An elevated oestrogen activity and a detectable level of testosterone were found. The cat... | ['Aneuploidy', 'Animals', 'Cat Diseases', 'Cats', 'Disorders of Sex Development', 'Female', 'Sex Chromosome Aberrations', 'Virilism'] | 25,611,903 | [['C23.550.210.050', 'G05.365.590.175.050', 'G05.700.131'], ['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C12.706.316', 'C13.351.875.253', 'C16.131.939.316', 'C19.391.119'], ['C23.550.210.815', 'G05.365.590.175.815'], ['C23.888.971']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Vascular aphasias: clinical, epidemiologicaland evolutionary aspects]. | INTRODUCTION: Aphasias constitute an acquired disorder of the language. Aetiologies are dominated by stroke. The aim of this study was to describe the clinical, epidemiological and evolutionary aspects of the vascular aphasias.MATERIALS AND METHODS: We conducted from August 2003 to May 2005 a descriptive cross-sectiona... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Aphasia', 'Aphasia, Broca', 'Aphasia, Wernicke', 'Cross-Sectional Studies', 'Education', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Senegal', 'Sex Factors', 'Stroke', 'Time Factors'] | 19,102,120 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.597.606.150.500.800.100', 'C23.888.592.604.150.500.800.100'], ['C10.597.606.150.500.800.100.100', 'C23.888.592.604.150.500.800.100.100'], ['C10.597.606.150.500.800.100.166', 'C23.888.592.604.150.500.800.100.166... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Differentiating moderate and severe depression using the Montgomery-Asberg depression rating scale (MADRS). | BACKGROUND: MADRS cut-off scores for moderate and severe depression were estimated in relation to the Hamilton Depression Rating Scale (HAMD(17)) and the Clinical Global Impressions Scale (CGI).METHOD: HAMD(17), MADRS, and CGI ratings from patients with major depression (DSM-IV) were analyzed (N=85). Receiver operating... | ['Adult', 'Aged', 'Depressive Disorder', 'Diagnosis, Differential', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Male', 'Mental Status Schedule', 'Middle Aged', 'Reference Values', 'Severity of Illness Index'] | 14,612,225 | [['M01.060.116'], ['M01.060.116.100'], ['F03.600.300'], ['E01.171'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.603.500', 'F04.711.513.653.574'], ['M01.060.116.630'], ['E05.978.810'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Evaluation of the application of national malaria treatment guidelines in private pharmacies in a rural area in the Democratic Republic of Congo. | In the Democratic Republic of the Congo, the first recourse in case of suspected malaria in the health system is the private pharmacy sector. This study was therefore designed to assess private provider adherence to national case management guidelines in Kimpese, a rural area of Central Kongo province. A descriptive cr... | ['Adult', 'Aged', 'Antimalarials', 'Artemether, Lumefantrine Drug Combination', 'Case Management', 'Cross-Sectional Studies', 'Democratic Republic of the Congo', 'Drug Combinations', 'Female', 'Guideline Adherence', 'Humans', 'Malaria', 'Male', 'Middle Aged', 'Pharmaceutical Services', 'Pharmacies', 'Private Sector', '... | 31,884,993 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.250.100.085'], ['D01.248.497.158.685.750.212.250.500', 'D01.339.431.374.212.250.500', 'D01.650.550.750.200.250.500', 'D02.389.338.055.250.500', 'D02.455.426.559.847.389.650.500', 'D02.455.849.765.211.250.500', 'D04.615.389.650.500', 'D26.310.110'], ['N04.590.233.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Evidence for follicle wall involvement in ovulation and progesterone production by frog (Rana pipiens) follicles in vitro. | Involvement of different cellular investments of the amphibian ovarian follicle wall in the ovulatory process, progesterone production, and oocyte maturation was investigated. Following microdissection, to selectively remove one or more layers (surface epithelium, theca, follicle cells) of the follicle wall, dissected ... | ['Animals', 'Cells, Cultured', 'Female', 'Oocytes', 'Ovarian Follicle', 'Ovulation', 'Pituitary Gland', 'Progesterone', 'Rana pipiens'] | 6,982,185 | [['B01.050'], ['A11.251'], ['A05.360.490.690.680', 'A11.497.497.600'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['G08.686.784.690'], ['A06.300.747', 'A06.688.357.750', 'A08.186.211.180.497.352.435.500', 'A08.186.211.200.317.357.352.435.500', 'A08.713.357.750'], ['D04.210.500.745.745.654.829', 'D06.472.334.73... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genotypic monoclonality in immunophenotypically polyclonal orbital lymphoid tumors. A model of tumor progression in the lymphoid system. The 1986 Wendell Hughes lecture. | Molecular genetic (genotypic) analysis elucidates gene rearrangements within lymphocytes that are responsible for either immunoglobulin production in B-lymphocytes or the expression of cell-surface antigen recognition receptors in T-lymphocytes. Molecular genetic analysis is far more sensitive than immunophenotypic met... | ['DNA', 'Female', 'Genes, Immunoglobulin', 'Humans', 'Hyperplasia', 'Lymphocytes', 'Lymphoma', 'Male', 'Middle Aged', 'Molecular Biology', 'Orbital Neoplasms'] | 3,658,376 | [['D13.444.308'], ['G05.360.340.024.340.335', 'G12.500.299'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['M01.060.116.630'], ['H01.158.201.636', 'H01.158.273.343.595'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Criteria for aspiration cytology for the diagnosis of seminoma. | Fine-needle aspiration cytology was performed in two cases of intra-abdominal tumors, one from retroperitoneal lymph nodes and one from a cryptorchid testis. The cytological diagnosis was consistent with seminoma in both cases. Cytological features included uniform neoplastic malignant cells with round nuclei and nucle... | ['Abdominal Neoplasms', 'Adult', 'Biopsy, Needle', 'Cryptorchidism', 'Cytodiagnosis', 'Dysgerminoma', 'Humans', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Testicular Neoplasms', 'Tomography, X-Ray Computed'] | 2,575,487 | [['C04.588.033'], ['M01.060.116'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C12.294.829.258', 'C12.706.258', 'C16.131.939.258', 'C19.391.829.258'], ['E01.370.225.500.384', '... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Silencing mediator of retinoic acid and thyroid hormone receptor regulates enhanced activation of signal transducer and activator of transcription 3 by epstein-barr virus-derived epstein-barr nuclear antigen 2. | The Epstein-Barr virus (EBV)-encoded latency protein Epstein-Barr nuclear antigen 2 (EBNA2) is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. In a previous study, we demonstrated that EBNA2 interacts with signal transducer and activator of transcription 3 (STAT3), a signa... | ['Antibodies, Monoclonal', 'DNA-Binding Proteins', 'Epstein-Barr Virus Nuclear Antigens', 'HeLa Cells', 'Humans', 'Immunoblotting', 'Immunoprecipitation', 'Interleukin-6', 'Luciferases', 'Nuclear Receptor Co-Repressor 2', 'RNA, Small Interfering', 'Repressor Proteins', 'Reverse Transcriptase Polymerase Chain Reaction',... | 19,571,399 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.260'], ['D23.050.290.249', 'D23.050.327.300'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['E05.196.150.6... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Loss of lamin A but not lamin C expression in epithelial ovarian cancer cells is associated with metastasis and poor prognosis. | OBJECTIVE: To elucidate the different roles of lamin A and lamin C in the metastasis of epithelial ovarian cancer (EOC) by examining their expression in EOC tissues and cell lines and their correlations with clinicopathological features.METHODS: The expression of lamin A and lamin C was assessed in ovarian tissues from... | ['Adult', 'Aged', 'Biomarkers, Tumor', 'Carcinoma, Ovarian Epithelial', 'Case-Control Studies', 'Cell Line, Tumor', 'Female', 'Humans', 'Immunohistochemistry', 'Lamin Type A', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasms, Glandular and Epithelial', 'Ovarian Neoplasms', 'Peritoneal Neoplasms', 'Prognosis', 'Surviva... | 25,499,720 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['C04.557.470.200.295', 'C04.588.322.455.199', 'C13.351.500.056.630.705.350', 'C13.351.937.418.685.350', 'C19.344.410.199', 'C19.391.630.705.350'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.251.210.190', 'A11.251.860.180'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
OPCAB surgery in a cirrhotic hepatocellular carcinoma patient awaiting liver transplant. | Cirrhosis was once thought of as an absolute contraindication to cardiac surgery with the risk of liver decompensation following the use of cardiopulmonary bypass. With the advent of off-pump coronary artery bypass grafting, the possibility of reducing the risk of decompensation may make this type of surgery suitable f... | ['Angina, Unstable', 'Carcinoma, Hepatocellular', 'Coronary Artery Bypass, Off-Pump', 'Coronary Stenosis', 'Diabetes Mellitus, Type 1', 'Humans', 'Liver Cirrhosis, Alcoholic', 'Liver Neoplasms', 'Liver Transplantation', 'Male', 'Middle Aged', 'Postoperative Hemorrhage', 'Saphenous Vein', 'Thoracic Arteries'] | 15,464,520 | [['C14.280.647.187.150', 'C14.907.585.187.150', 'C23.888.592.612.233.500.150'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E04.100.376.719.332.199', 'E04.100.814.868.750.199', 'E04.928.220.520.220.189'], ['C14.280.647.250.285', 'C14.907.585.250.285'], ['C18.452.394.750.1... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833. | PURPOSE: PSC 833 (valspodar) is a second-generation P-glycoprotein (Pgp) antagonist developed to reverse multidrug resistance. We conducted a phase I study of a 7-day oral administration of PSC 833 in combination with paclitaxel, administered as a 96-hour continuous infusion.PATIENTS AND METHODS: Fifty patients with ad... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Administration, Oral', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents, Phytogenic', 'Antineoplastic Combined Chemotherapy Protocols', 'CD56 Antigen', 'Cyclosporins', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule... | 11,157,037 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['E02.319.267.100'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cadmium risk assessment in relation to background risk of chronic kidney disease. | Cadmium's noncancer effects on the kidney represent a useful case study of the unified approach to toxicity assessment described in a recent National Academy of Science report. Cadmium (Cd) is recognized to exert toxic effects on the kidney at low dose without a demonstrable threshold. The implications of current dieta... | ['Age Factors', 'Aged', 'Cadmium', 'Dose-Response Relationship, Drug', 'Environmental Exposure', 'Female', 'Food Contamination', 'Glomerular Filtration Rate', 'Humans', 'Middle Aged', 'Models, Biological', 'Renal Insufficiency, Chronic', 'Risk Assessment'] | 22,524,593 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['G07.690.773.875', 'G07.690.936.500'], ['N06.850.460.350'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.3... | ['Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Findings, diagnoses and results of a halitosis clinic over a seven year period. | Halitosis or bad breath is a taboo subject that is a widespread problem in the general population. Causes of bad breath can be multifactorial and long time sufferers can be marred from deep psychological stress. Because nine out of ten cases have an oral cause, the initial inquiry should be with a dentist. In a retrosp... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Breath Tests', 'Child', 'Female', 'Halitosis', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Social Alienation', 'Sulfur Compounds', 'Surveys and Questionnaires', 'Young Adult'] | 22,418,723 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.100'], ['M01.060.406'], ['C23.888.821.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Binding of pregnancy-associated plasma protein-A (PAPP-A) to placental subfractions. | Pregnancy-associated plasma protein-A (PAPP-A) has been shown to exert immunosuppressive effects both on complement and on lymphoblastogenesis. It was of interest to see whether this protein could bind to syncytiotrophoblast microvillous membranes since these represent the effective interface between fetal tissue and t... | ['Cell Membrane', 'Decidua', 'Female', 'Humans', 'Microvilli', 'Placenta', 'Pregnancy', 'Pregnancy Proteins', 'Pregnancy Trimester, Third', 'Pregnancy-Associated Plasma Protein-A', 'Radioimmunoassay', 'Subcellular Fractions', 'Trophoblasts'] | 2,420,292 | [['A11.284.149'], ['A05.360.319.679.490.373', 'A16.710.289'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.180.565'], ['A16.710'], ['G08.686.784.769'], ['D12.776.780'], ['G08.686.707.520'], ['D08.811.277.656.300.480.632', 'D08.811.277.656.675.374.632', 'D12.776.780.700'], ['E01.370.384.700', 'E05.478.566.... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ketoacidosis in Neonatal Diabetes Mellitus, Part of Wolcott-Rallison Syndrome. | BACKGROUND Neonatal diabetes mellitus is a rare condition and it is important to differentiate it from other causes, such as hyperglycemia in infancy, for better outcomes. We report a case of an infant who presented to our neonatal intensive care unit in ketoacidosis and a comatose state. CASE REPORT Our case was an in... | ['Adult', 'Consanguinity', 'Diabetes Mellitus, Type 1', 'Diabetic Ketoacidosis', 'Epiphyses', 'Female', 'Genetic Testing', 'Humans', 'Infant, Newborn', 'Mutation, Missense', 'Osteochondrodysplasias', 'eIF-2 Kinase'] | 28,652,565 | [['M01.060.116'], ['G05.090.403.180', 'G05.180'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C18.452.076.176.652.500', 'C18.452.394.750.535', 'C19.246.099.812'], ['A02.835.232.251'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical and radiologic features of pigmented villonodular synovitis of the foot: report of eight cases. | Pigmented villonodular synovitis, a rare proliferative disease of unknown etiology, is rare in the foot (2% of these lesions). A retrospective review was undertaken of the case histories, radiographs, and imaging results of eight patients treated for pigmented villonodular synovitis of the foot. Pigmented villonodular ... | ['Adolescent', 'Adult', 'Child', 'Foot', 'Humans', 'Middle Aged', 'Radiography', 'Retrospective Studies', 'Synovitis, Pigmented Villonodular'] | 17,901,349 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['A01.378.610.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Examining location-based and object-based components of inhibition of return in static displays. | Tipper and Colleagues (e.g., Jordan & Tipper, 1998; Tipper, Driver, & Weaver, 1991; Tipper, Weaver, Jerreat, & Burak, 1994) have provided support for inhibition of return (IOR) being composed of a location-based and an object-based component. They were able to separate out the effects of location-based and object-based... | ['Attention', 'Humans', 'Inhibition, Psychological', 'Motion Perception', 'Orientation', 'Pattern Recognition, Visual', 'Psychophysics', 'Reaction Time'] | 11,578,051 | [['F02.830.104.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.544', 'F02.463.425.475', 'F02.739.794.405'], ['F02.463.593.932.567'], ['F01.058.577', 'F02.830.606'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E01.370.685', 'F04.096.753'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.67... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accumulation of mature mRNA in the nuclear fraction of mammalian cells. | Little is known about the nuclear mRNA content of mammalian cells. In this study, we analyzed by Northern blotting with a panel of probes the nuclear and cytoplasmic fractions derived from several rodent cell lines. For most of the genes under study, mature mRNAs could easily be detected in the nuclear fraction and acc... | ['Animals', 'Biological Transport', 'Blotting, Northern', 'Cell Division', 'Cell Line', 'Cell Nucleus', 'Cytoplasm', 'DNA Probes', 'Kinetics', 'Mice', 'Nuclear Matrix', 'RNA, Messenger', 'Rats'] | 10,570,933 | [['B01.050'], ['G03.143'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of p53 expression in osteosarcoma of the jaw: correlation with clinicopathologic and DNA ploidy findings. | The objective of this study was to determine whether p53 expression correlated with clinicopathological and DNA ploidy in osteosarcoma of the jaw, a particular subtype of osteosarcoma associated with an older age at presentation, longer median survival, rare metastasis, and death due to uncontrolled local recurrence. S... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'DNA, Neoplasm', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, p53', 'Humans', 'Jaw Neoplasms', 'Male', 'Middle Aged', 'Osteosarcoma', 'Ploidies', 'Staining and Labeling', 'Survival Analysis'] | 9,416,691 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D13.444.308.425'], ['G05.308.370'], ['G05.360.340.024.340.375.249.385', 'G05.360.340.024.340.415.400.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.149.721.450', 'C05.116.231.754.450', 'C05.500.499', 'C07.320.515'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Orthodontic treatment complexity and need in a group of Nigerian patients: the relationship between the Dental Aesthetic Index (DAI) and the Index of Complexity, Outcome, and Need (ICON). | AIM: The aim of this retrospective analytical study was to assess the relationship between the Dental Aesthetic Index (DAI) and the Index of Complexity, Outcome, and Need (ICON) on the orthodontic treatment need and complexity in a group of Nigerian patients.METHODS AND MATERIALS: Fifty-six cases were randomly selected... | ['Dental Health Surveys', 'Esthetics, Dental', 'Female', 'Health Services Needs and Demand', 'Humans', 'Male', 'Malocclusion', 'Nigeria', 'Orthodontics, Corrective', 'Reproducibility of Results', 'Retrospective Studies', 'Statistics, Nonparametric'] | 17,351,680 | [['E05.318.308.980.438.300', 'E06.208', 'N05.715.360.300.800.438.300', 'N06.850.520.308.980.438.300', 'N06.890.160'], ['E06.420'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.793.494'], ['Z01.058.290.190.565'], ['E06.658.578'], ['E05.318.370.725', 'E05.337.851', 'N05.715.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Solution structure of subunit F(6) from the peripheral stalk region of ATP synthase from bovine heart mitochondria. | The ATP synthase enzyme structure includes two stalk assemblies, the central stalk and the peripheral stalk. Catalysis involves rotation of the central stalk assembly together with the membrane-embedded ring of c-subunits driven by the trans-membrane proton-motive force, while the alpha and beta-subunits of F(1) are pr... | ['Animals', 'Cattle', 'Magnetic Resonance Spectroscopy', 'Mitochondria', 'Mitochondrial Proton-Translocating ATPases', 'Myocardium', 'Protein Structure, Tertiary'] | 15,327,958 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.867.519'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D08.811.277.040.025.325.750', 'D08.811.913.696.650.150.500.750', 'D12.776.157.530.450.250.875.500.750', 'D12.776.543.585.450.250.875.500.750', 'D12.776.543.585.475.625', 'D12.776.575.750.625... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Effectiveness of Using the Critical Shoulder Angle and Acromion Index for Predicting Rotator Cuff Tears: Accurate Diagnosis Based on Standard and Nonstandard Anteroposterior Radiographs. | PURPOSE: To explore whether the critical shoulder angle (CSA) and acromion index (AI) on nonstandard anteroposterior (AP) radiographs could be used as parameters for rotator cuff tear (RCT) diagnosis and to determine the optimized parameters.METHODS: This study included 174 patients with RCTs or intact rotator cuffs in... | ['Acromion', 'Adult', 'Aged', 'Case-Control Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'ROC Curve', 'Radiography', 'Rotator Cuff', 'Rotator Cuff Injuries', 'Shoulder Joint', 'Young Adult'] | 31,421,961 | [['A02.835.232.087.783.261'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], [... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Survival of Cryptosporidium parvum oocysts recovered from experimentally contaminated oysters (Ostrea edulis) and clams (Tapes decussatus). | Samples of two species of shellfish that form part of the human food chain (the oyster Ostrea edulis and the marine clam Tapes decussatus) were experimentally contaminated with Cryptosporidium parvum oocysts. Changes in the viability of oocysts subsequently recovered from the shellfish were evaluated by means of an imm... | ['Animals', 'Bivalvia', 'Cattle', 'Cryptosporidium parvum', 'Food Chain', 'Host-Parasite Interactions', 'Mice', 'Oocysts', 'Ostreidae', 'Parasite Egg Count', 'Water Microbiology'] | 11,936,501 | [['B01.050'], ['B01.050.500.644.080'], ['B01.050.150.900.649.313.500.380.271'], ['B01.043.075.189.250.150.160.170'], ['G16.500.275.157.250', 'N06.230.124.250'], ['G16.527.200.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.870.740.600', 'B05.500.675', 'B05.775.740.600', 'G07.345.500.550.500.675'], ['B01.050.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Reference point insensitive molecular data analysis. | MOTIVATION: In biomedicine, every molecular measurement is relative to a reference point, like a fixed aliquot of RNA extracted from a tissue, a defined number of blood cells, or a defined volume of biofluid. Reference points are often chosen for practical reasons. For example, we might want to assess the metabolome of... | ['Algorithms', 'Bacteria', 'Computational Biology', 'Computer Simulation', 'Gastrointestinal Microbiome', 'Gene Expression Regulation, Bacterial', 'Humans', 'Metabolomics', 'Software'] | 27,634,945 | [['G17.035', 'L01.224.050'], ['B03'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.160'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['G05.308.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Surveillance of vibriophages reveals their role as biomonitoring agents in Kolkata. | Cholera is a public health threat in all developing countries. Kolkata, a city in eastern India, is an endemic zone for cholera. During the course of a comprehensive investigation on the distribution of phages of Vibrio cholerae O1 and O139 in freshwater bodies in Kolkata, we were able to isolate the phages of V. chole... | ['Bacteriophages', 'Cholera', 'DNA, Bacterial', 'Environmental Monitoring', 'Epidemiological Monitoring', 'Genes, Bacterial', 'India', 'Seasons', 'Vibrio cholerae O1', 'Vibrio cholerae O139', 'Water Microbiology'] | 19,220,862 | [['B04.123'], ['C01.150.252.400.959.347'], ['D13.444.308.212'], ['N06.850.460.350.080', 'N06.850.780.375'], ['E05.318.375', 'N06.850.520.460'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['Z01.252.245.393'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
[Infections in children with leukaemia or malignant tumour treated with cytostatic agents: long-term study of 200 cases (author's transl)]. | All children with leukaemia or malignant tumour receiving cytostatic agents were followed by virological tests over three years. Serological tests or virus isolation in 200 children demonstrated 238 instances of viral infection. Only those of the herpes group led to severe symptoms which, however, responded to treatmen... | ['Adolescent', 'Antineoplastic Agents', 'Child', 'Child, Preschool', 'Herpesviridae Infections', 'Humans', 'Leukemia', 'Neoplasms', 'Pneumonia, Pneumocystis', 'Virus Diseases'] | 6,260,450 | [['M01.060.057'], ['D27.505.954.248'], ['M01.060.406'], ['M01.060.406.448'], ['C01.925.256.466'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['C04'], ['C01.150.703.534.700', 'C01.150.703.770.700', 'C01.748.435.700', 'C01.748.610.675', 'C08.381.472.700', 'C08.381.677.675', 'C08.730.435.700', 'C08.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A phase I trial of imetelstat in children with refractory or recurrent solid tumors: a Children's Oncology Group Phase I Consortium Study (ADVL1112). | PURPOSE: Imetelstat is a covalently-lipidated 13-mer thiophosphoramidate oligonucleotide that acts as a potent specific inhibitor of telomerase. It binds with high affinity to the template region of the RNA component of human telomerase (hTERC) and is a competitive inhibitor of telomerase enzymatic activity. The purpos... | ['Adolescent', 'Antineoplastic Agents', 'Area Under Curve', 'Bone Neoplasms', 'Child', 'Child, Preschool', 'Drug Administration Schedule', 'Drug Resistance, Neoplasm', 'Female', 'Humans', 'Indoles', 'Leukocytes, Mononuclear', 'Male', 'Neoplasm Recurrence, Local', 'Neuroblastoma', 'Niacinamide', 'Oligonucleotides', 'Sar... | 24,097,866 | [['M01.060.057'], ['D27.505.954.248'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['C04.588.149', 'C05.116.231'], ['M01.060.406'], ['M01.060.406.448'], ['E02.319.283'], ['G07.690.773.984.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['A11.118.637.555', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
On the bilateral innervation of masticatory muscles: a study with retrograde tracers. | Using horseradish peroxidase and fluorescent compounds as retrograde tracers, the myotopical arrangement and axon trajectories of the motoneurons innervating the supramandibular and the suprahyoidal muscles were studied in the rat. Only motoneurons ipsilateral to the injection site were labelled. In the trigeminal moto... | ['Animals', 'Benzimidazoles', 'Benzofurans', 'Female', 'Fluorescent Dyes', 'Horseradish Peroxidase', 'Masticatory Muscles', 'Rats', 'Rats, Inbred Strains', 'Staining and Labeling'] | 2,416,722 | [['B01.050'], ['D03.633.100.103'], ['D03.633.100.127'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D08.811.682.732.512'], ['A02.633.567.600', 'A14.530'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['E01.370.225.500.620.670', 'E01.370.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Down-regulated LAMA4 inhibits oxidative stress-induced apoptosis of retinal ganglion cells through the MAPK signaling pathway in rats with glaucoma. | Glaucoma is a neurodegenerative disorder that is generally accepted as the main cause of vision loss. In this study, we tested the hypothesis that laminin á4 (LAMA4) is implicated in glaucoma development by controlling apoptosis of retinal ganglion cells (RGCs) through the mitogen-activated protein kinase (MAPK) signal... | ['Animals', 'Apoptosis', 'Cell Survival', 'Cells, Cultured', 'Disease Models, Animal', 'Down-Regulation', 'Glaucoma', 'Hydrogen Peroxide', 'Intraocular Pressure', 'Laminin', 'Male', 'Oxidative Stress', 'Rats', 'Rats, Wistar', 'Reactive Oxygen Species', 'Retinal Ganglion Cells', 'Signal Transduction', 'Transfection', 'p... | 30,874,465 | [['B01.050'], ['G04.146.954.035'], ['G04.346'], ['A11.251'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['C11.525.381'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['G14.440'], ['D12.776.395.550.530', 'D12.776.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications. | Mn(III) N-alkylpyridylporphyrins (MnPs) have demonstrated protection in various conditions where increased production of reactive oxygen/reactive nitrogen species (ROS/RNS), is a key pathological factors. MnPs can produce both pro-oxidative and antioxidative effects depending upon the cellular redox environment that th... | ['Animals', 'Biomimetic Materials', 'Diabetes Complications', 'Diabetes Mellitus, Experimental', 'Drug Administration Schedule', 'Gene Expression Regulation', 'Humans', 'Kidney', 'Male', 'Metalloporphyrins', 'Oxidative Stress', 'Rats', 'Rats, Wistar', 'Streptozocin', 'Superoxide Dismutase'] | 24,191,241 | [['B01.050'], ['J01.637.087'], ['C19.246.099'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['E02.319.283'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['D02.257.250', 'D03.383.129.578.840.500.640', 'D03.633.400.909.500.640', 'D04.345.783.500.640', 'D23.767.727.640'], ... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Autosomal dominant onychodystrophy and anonychia with type B brachydactyly and ectrodactyly. | A family is reported with nail dysplasia and/or absent nails, long and broad finger-like thumbs, camptodactyly and absent fingers. Radiological studies revealed hypoplasia of metacarpals, metatarsals and distal phalanges. Two affected individuals have absent metacarpals and phalanges. The clinical and radiological feat... | ['Adult', 'Dermatoglyphics', 'Female', 'Fingers', 'Genes, Dominant', 'Humans', 'Male', 'Nails, Malformed', 'Pedigree', 'Syndrome'] | 3,780,038 | [['M01.060.116'], ['E05.318.740.225.500.375', 'I01.198.780.937.343', 'N04.452.910.099.500'], ['A01.378.800.667.430'], ['G05.360.340.024.340.240', 'G05.420.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.300.820'], ['E05.393.673'], ['C23.550.288.500']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Rapid and deep-scale ubiquitylation profiling for biology and translational research. | Protein ubiquitylation is involved in a plethora of cellular processes. While antibodies directed at ubiquitin remnants (K-?-GG) have improved the ability to monitor ubiquitylation using mass spectrometry, methods for highly multiplexed measurement of ubiquitylation in tissues and primary cells using sub-milligram amou... | ['Animals', 'Breast Neoplasms', 'Casein Kinase Ialpha', 'Female', 'HeLa Cells', 'Humans', 'Ikaros Transcription Factor', 'Mass Spectrometry', 'Mice', 'Multiple Myeloma', 'Protein Processing, Post-Translational', 'Proteins', 'Proteome', 'Proteomics', 'Sensitivity and Specificity', 'Staining and Labeling', 'Translational... | 31,953,384 | [['B01.050'], ['C04.588.180', 'C17.800.090.500'], ['D05.500.117.750.100', 'D08.811.913.696.620.682.700.140.300.100', 'D12.776.476.081.750.100', 'D12.776.476.150.299.100'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.260.522.500', 'D12.776.930... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Escherichia coli ribonucleotide reductase. Radical susceptibility to hydroxyurea is dependent on the regulatory state of the enzyme. | Ribonucleotide reductase catalyzes the reduction of ribonucleotides to their corresponding deoxyribonucleotides via a radical-mediated mechanism. The enzyme from Escherichia coli consists of the two non-identical proteins, R1 and R2, the latter of which contains the necessary free radical located to a tyrosine residue.... | ['Escherichia coli', 'Hydroxyurea', 'Kinetics', 'Mutation', 'Ribonucleotide Reductases', 'Temperature'] | 1,618,767 | [['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.065.950.395'], ['G01.374.661', 'G02.111.490'], ['G05.365.590'], ['D08.811.682.810'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rumination and negative symptoms in schizophrenia. | Rumination is thought to be an important maintaining factor in depression. Depressive symptomatology is also a prominent feature in schizophrenia. However, little is known about the relationship between rumination and symptoms, such as depression and negative symptoms, in schizophrenia. The present study examined assoc... | ['Adaptation, Psychological', 'Adult', 'Cognition Disorders', 'Depression', 'Female', 'Humans', 'Male', 'Middle Aged', 'Personality Inventory', 'Psychiatric Status Rating Scales', 'Psychotic Disorders', 'Schizophrenia', 'Schizophrenic Psychology', 'Stress, Psychological', 'Surveys and Questionnaires'] | 19,752,652 | [['F01.058'], ['M01.060.116'], ['F03.615.250'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.647.513'], ['F04.711.513.653'], ['F03.700.675'], ['F03.700.750'], ['F04.824'], ['F01.145.126.990', 'F02.830.900'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Add-on grade-ranking scale for assessing thrombotic risk in patients with ischemic heart disease and percutaneous coronary angioplasty. | OBJECTIVE: Introduction: The anticipation of the development of thrombotic complications in coronary angioplasty patients helps to prevent this dangerous complication. Development of the available informative scales on the basis of mathematical methods taking into account the main clinical and biochemical parameters si... | ['Angioplasty, Balloon, Coronary', 'Coronary Disease', 'Diabetes Mellitus', 'Humans', 'Recurrence', 'Risk Assessment', 'Risk Factors', 'Thrombosis'] | 31,622,255 | [['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['C14.280.647.250', 'C14.907.585.250'], ['C18.452.394.750', 'C19.246'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Polyphenolic enriched extract of Cassia glauca Lamk, improves streptozotocin-induced type-1 diabetes linked with partial insulin resistance in rats. | ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally Cassia glauca (CG) has been used to treat diabetes.AIM OF THE STUDY: The study was undertaken to evaluate anti-diabetic and antioxidant activity of polyphenolic enriched extract of CG in standardized streptozotocin (STZ)-induced diabetic rats.MATERIALS AND METHODS: The effe... | ['Animals', 'Antioxidants', 'Blood Glucose', 'Cassia', 'Diabetes Mellitus, Experimental', 'Diabetes Mellitus, Type 1', 'Dose-Response Relationship, Drug', 'Glucose Tolerance Test', 'Hypoglycemic Agents', 'Insulin Resistance', 'Male', 'Oxidative Stress', 'Plant Extracts', 'Polyphenols', 'Rats', 'Rats, Wistar', 'Streptoz... | 28,109,916 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D09.947.875.359.448.500'], ['B01.650.940.800.575.912.250.401.100'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.124.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Designed coiled coils promote folding of a recombinant bacterial collagen. | Collagen triple helices fold slowly and inefficiently, often requiring adjacent globular domains to assist this process. In the Streptococcus pyogenes collagen-like protein Scl2, a V domain predicted to be largely á-helical, occurs N-terminal to the collagen triple helix (CL). Here, we replace this natural trimerizatio... | ['Bacterial Proteins', 'Collagen', 'Hot Temperature', 'Protein Folding', 'Protein Structure, Secondary', 'Protein Structure, Tertiary', 'Recombinant Proteins', 'Streptococcus pyogenes'] | 21,454,493 | [['D12.776.097'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G01.154.651', 'G02.111.688'], ['G02.111.570.820.709.600'], ['G02.111.570.820.709.610'], ['D12.776.828'], ['B03.353.750.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Primary care provider practices and beliefs related to cervical cancer screening with the HPV test in Federally Qualified Health Centers. | OBJECTIVE: Cervical cancer screening using the human papillomavirus (HPV) test and Pap test together (co-testing) is an option for average-risk women ? 30 years of age. With normal co-test results, screening intervals can be extended. The study objective is to assess primary care provider practices, beliefs, facilitato... | ['Adult', 'Attitude of Health Personnel', 'Cross-Sectional Studies', 'Culture', 'Early Detection of Cancer', 'Female', 'Health Knowledge, Attitudes, Practice', 'Health Services Misuse', 'Health Services Research', 'Hospitals, Federal', 'Humans', 'Illinois', 'Papillomavirus Infections', "Practice Patterns, Physicians'",... | 23,628,517 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.076.201.450', 'I01.880.853.100'], ['E01.390.500'], ['F01.100.150.500', 'N05.300.150.410'], ['N02.421.380', 'N05.300.150.395'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['N02.2... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Treatment with natalizumab in relapsing-remitting multiple sclerosis patients induces changes in inflammatory mechanism. | Natalizumab is a widely accepted drug for the relapsing-remitting subtype of multiple sclerosis (RRMS). The present longitudinal exploratory study in RRMS patients analyzes the effects of natalizumab treatment on the levels of pro-inflammatory and anti-inflammatory cytokine protein levels and also the frequency and sup... | ['Adult', 'Antibodies, Monoclonal, Humanized', 'Cell Proliferation', 'Cytokines', 'Female', 'Humans', 'Integrin alpha4beta1', 'Longitudinal Studies', 'Male', 'Multiple Sclerosis, Relapsing-Remitting', 'Natalizumab', 'Recurrence', 'T-Lymphocytes, Regulatory'] | 21,491,095 | [['M01.060.116'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.200.625.347', 'D12.776.543.550.20... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Endobronchial ultrasound with transbronchial needle aspiration in the diagnosis of bilateral hilar and mediastinal lymphadenopathy. | BACKGROUND: : Bilateral hilar and/or mediastinal lymphadenopathy (BHL±ML) is an important radiographic finding. Since it was examined 38 years ago by Winterbauer and colleagues, better diagnostic techniques have been developed. The purpose of this study was to reexamine the diagnosis of BHL±ML by Endobronchial Ultrasou... | ['Diagnosis, Differential', 'Endoscopic Ultrasound-Guided Fine Needle Aspiration', 'Endosonography', 'Female', 'Humans', 'Lung Diseases', 'Lymph Nodes', 'Lymphatic Diseases', 'Lymphoma', 'Male', 'Mediastinal Diseases', 'Middle Aged', 'Retrospective Studies', 'Sarcoidosis'] | 23,207,258 | [['E01.171'], ['E01.370.225.500.384.100.119.500.500', 'E01.370.225.500.384.100.370.500', 'E01.370.225.998.054.119.500.500', 'E01.370.225.998.054.370.500', 'E01.370.350.850.855.500', 'E01.370.388.100.100.500.500', 'E01.370.388.100.370.500', 'E04.074.119.500.500', 'E04.074.370.500', 'E04.502.890.500', 'E05.200.500.384.10... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Responses of cerebral arterioles to N-methyl-D-aspartate and activation of ATP-sensitive potassium channels in old rats. | The first goal of this study was to examine the hypothesis that aging impairs dilator responses of cerebral arterioles to N-methyl-D-aspartate (NMDA). The second goal was to determine whether aging impairs vasodilatation in response to activation of ATP-sensitive K+ channels. Diameter of cerebral arterioles was measure... | ['Adenosine Triphosphate', 'Aging', 'Animals', 'Arterioles', 'Cerebrovascular Circulation', 'Dose-Response Relationship, Drug', 'Male', 'N-Methylaspartate', 'Picolines', 'Potassium Channels', 'Pyrans', 'Rats', 'Rats, Inbred F344', 'Vasodilator Agents'] | 7,987,685 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G07.345.124'], ['B01.050'], ['A07.015.114.060', 'A07.015.461.080'], ['G09.330.100.159'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.125.067.500.400', 'D12.125.119.170.400'], ['D03.383.725.676'], ['D12.776.157.530.400.600', 'D12.776.543... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Effects of Exercise, Aspirin, and Celecoxib in an Atherogenic Environment. | INTRODUCTION: Optimal vascular function is a hallmark of cardiovascular health. Specifically, the balance of vasoconstricting and vasodilating substances is recognized as a marker of vascular health. One of the greatest challenges to vascular health and vasodilatory balance is tumor necrosis factor alpha (TNFá)-mediate... | ['Anti-Inflammatory Agents, Non-Steroidal', 'Aspirin', 'Atherosclerosis', 'Celecoxib', 'Cells, Cultured', 'Epoprostenol', 'Exercise', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Inflammation', 'Nitric Oxide Synthase Type III', 'Stress, Mechanical', 'Thromboxane B2', 'Tumor Necrosis Factor-alpha'] | 29,771,821 | [['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D02.455.426.559.389.657.410.595.176'], ['C14.907.137.126.307'], ['D02.065.884.247', 'D02.886.590.700.247', 'D03.383.129.539.160'], ['A11.251'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['G11.427.410.698.277', 'I... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Morphology of the muscle articulation joint between the hooks of a flatworm (Kalyptorhynchia, Cheliplana sp.). | Schizorhynch kalyptorhynchs are meiofaunal turbellarian predators that possess an eversible proboscis that can be armed with two stout hooks. The hooks grasp and manipulate prey using a wide range of rotations and translations. These diverse motions are possible because the hook supports may function as a muscle articu... | ['Animals', 'Joints', 'Microscopy', 'Microscopy, Confocal', 'Microscopy, Electron, Transmission', 'Models, Biological', 'Muscles', 'Turbellaria'] | 20,413,793 | [['B01.050'], ['A02.835.583'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['E05.599.395'], ['A02.633', 'A10.690'], ['B01.050.500.500.736.847']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Blood level, distribution, metabolite pattern and excretion of [14C]alinidine in mice and rats. | Following oral and intravenous administration the absorption, distribution, metabolite pattern and excretion of [14C]alinidine, a drug with specific bradycardic efficacy, was studied in mice and rats. [14C]alinidine was rapidly and extensively absorbed. The distribution of radio-labelled drug over the entire animal bod... | ['Administration, Oral', 'Animals', 'Autoradiography', 'Bile', 'Chromatography, High Pressure Liquid', 'Clonidine', 'Female', 'Injections, Intravenous', 'Intestinal Absorption', 'Kinetics', 'Male', 'Mice', 'Protein Binding', 'Rats', 'Tissue Distribution'] | 3,816,873 | [['E02.319.267.100'], ['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A12.200.087'], ['E05.196.181.400.300'], ['D03.383.129.308.436.500'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of Binderless ZK-4 Zeolite Microspheres at High Temperature. | Binderless zeolite macrostructures in the form of ZK-4 microspheres were prepared using anion-exchange resin beads as shape-directing macrotemplates. The particles were synthesized under hydrothermal conditions at different temperatures and treatment times. The influence of the different synthesis parameters was invest... | ['Adsorption', 'Decontamination', 'Hot Temperature', 'Microscopy, Electron, Scanning', 'Microspheres', 'Particle Size', 'Volatile Organic Compounds', 'X-Ray Diffraction', 'Zeolites'] | 30,332,752 | [['G01.030', 'G02.020'], ['N06.850.780.325'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E07.565'], ['G02.712'], ['D02.974'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.95... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Expression of parathyroid hormone-related protein mRNA by uterine tissues and extraembryonic membranes during gestation in rats. | Hybridization histochemistry and solution hybridization studies were performed to localize the expression of parathyroid hormone-related protein (PTHrP) during implantation in rats. Parallel studies were performed on rat uteri bearing oil-induced deciduomata and on cultured blastocysts. PTHrP mRNA begins to be expresse... | ['Animals', 'Blastocyst', 'Decidua', 'Embryo Implantation', 'Extraembryonic Membranes', 'Female', 'Gene Expression', 'Histocytochemistry', 'In Situ Hybridization', 'Parathyroid Hormone', 'Parathyroid Hormone-Related Protein', 'Pregnancy', 'Pregnancy, Animal', 'Proteins', 'Pseudopregnancy', 'RNA, Messenger', 'Rats', 'Ra... | 8,107,015 | [['B01.050'], ['A16.254.500'], ['A05.360.319.679.490.373', 'A16.710.289'], ['G08.686.784.170.104.500'], ['A10.615.284', 'A16.254.750'], ['G05.297'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['E01.370.225.500.620.67... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Temperature-Induced Collapse, and Arrested Collapse, of Anisotropic Endoskeleton Droplets. | Micron-scale rod-shaped droplets with a range of aspect ratios are produced using extrusion of oil containing a soft wax crystal network to permit shape customization. A physical model of the droplet shape stability is developed based on balancing interfacial stresses with the internal crystal network yield stress. The... | ['Alkanes', 'Anisotropy', 'Particle Size', 'Petrolatum', 'Surface Properties', 'Temperature'] | 26,177,777 | [['D02.455.326.146'], ['G01.590.040', 'G02.050'], ['G02.712'], ['D02.455.699'], ['G02.860'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress. | The abundant nuclear complex termed FACT affects several DNA transactions in a chromatin context, including transcription, replication, and repair. Earlier studies of yeast FACT, which indicated the apparent dispensability of conserved sequences at the N terminus of the FACT subunit Cdc68/Spt16, prompted genetic and bi... | ['Amino Acid Sequence', 'Carrier Proteins', 'Cell Cycle Proteins', 'Conserved Sequence', 'DNA Replication', 'Histones', 'Molecular Chaperones', 'Mutation', 'Protein Structure, Tertiary', 'Protein Subunits', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Transcription Factors', 'Transcriptional Elonga... | 15,520,471 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.157'], ['D12.776.167'], ['G02.111.570.580'], ['G02.111.225', 'G05.226'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['D12.776.580'], ['G05.365.590'], ['G02.111.570.820.709.610'], ['D12.776.813'], ['B01.300.107.795.785.800', 'B01.300.930.705.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Officer friendly and the tough cop:gays and lesbians navigate homophobia and policing. | Despite attempts to expand social diversity, policing is still dominated by a white, masculine, heterosexual ethos. As a consequence, employment of lesbians and gay men as police officers may be especially threatening to members of this occupation. Within the context of potential hostility and homophobia, nontraditiona... | ['Adult', 'Female', 'Homosexuality, Female', 'Homosexuality, Male', 'Humans', 'Male', 'Police', 'Prejudice', 'Stereotyping'] | 15,189,784 | [['M01.060.116'], ['F01.145.802.975.500.400', 'G08.686.867.500.400'], ['F01.145.802.975.500.600', 'G08.686.867.500.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.373.750', 'M01.526.760'], ['F01.145.813.550', 'F01.829.595'], ['F01.100.920', 'F01.145.813.854']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A dynamic intravascular artificial lung. | Intravascular lung assist devices (ILADs) must transfer sufficient amounts of oxygen and carbon dioxide to and from limited surface areas. It has become apparent that passive devices, i.e., those without an active means for enhancing transfer, cannot achieve sufficient transfer within the space available. High speed ro... | ['Artificial Organs', 'Biomedical Engineering', 'Carbon Dioxide', 'Evaluation Studies as Topic', 'Humans', 'In Vitro Techniques', 'Lung', 'Oscillometry', 'Oxygen', 'Pressure', 'Pulmonary Gas Exchange', 'Rotation'] | 8,555,615 | [['E07.858.082'], ['H02.070', 'J01.293.140'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A04.411'], ['E05.654'], ['D01.268.185.550', 'D01.362.670'], ['G01.374.715'], ['E01.370.386.700.650', 'G03.143.775.602', 'G09.77... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Evaluation of the highest concentrations used in the in vitro chromosome aberrations assay. | There is controversy over the highest concentration to which an article should be tested in in vitro mammalian cell assays of genetic toxicity. Until recently, most guidelines specified the use of concentrations of up to 10 mM or 5,000 ìg/ml (whichever is lower) when not limited by the toxicity of the test article to t... | ['Animals', 'Carcinogens', 'Chromosome Aberrations', 'Dose-Response Relationship, Drug', 'Monte Carlo Method', 'Mutagenicity Tests', 'Rodentia', 'Sensitivity and Specificity'] | 23,076,808 | [['B01.050'], ['D27.888.569.100'], ['C23.550.210', 'G05.365.590.175'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E05.393.560', 'E05.940.560'], ['B01.050.150.900.649.313.992'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. | Identification of common mechanistic principles that shed light on the action of the many chemically diverse toxicants to which we are exposed is of central importance in understanding how toxicants disrupt normal cellular function and in developing more effective means of protecting against such effects. Of particular... | ['Acetylcysteine', 'Animals', 'Cell Division', 'Cell Nucleus', 'Cells, Cultured', 'Environmental Pollutants', 'Enzyme Activation', 'Female', 'Free Radical Scavengers', 'Lead', 'Methylmercury Compounds', 'Mice', 'Neuroglia', 'Oxidation-Reduction', 'Paraquat', 'Platelet-Derived Growth Factor', 'Proto-Oncogene Proteins c-... | 17,298,174 | [['D02.886.030.230.259', 'D12.125.166.230.259'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.251'], ['D27.888.284'], ['G02.111.263', 'G03.328'], ['D27.505.519.217.500'], ['D01.268.556.435', 'D01.552.544.435'], ['D02.691... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanotransduction via TRPV4 regulates inflammation and differentiation in fetal mouse distal lung epithelial cells. | BACKGROUND: Mechanical ventilation plays a central role in the injury of premature lungs. However, the mechanisms by which mechanical signals trigger an inflammatory cascade to promote lung injury are not well-characterized. Transient receptor potential vanilloid 4 (TRPV4), a calcium-permeable mechanoreceptor channel h... | ['Animals', 'Cell Differentiation', 'Cells, Cultured', 'Epithelial Cells', 'Female', 'Fetus', 'Inflammation', 'Mechanotransduction, Cellular', 'Mice', 'Mice, Inbred C57BL', 'Pregnancy', 'Respiratory Mucosa', 'TRPV Cation Channels'] | 26,006,045 | [['B01.050'], ['G04.152'], ['A11.251'], ['A11.436'], ['A16.378'], ['C23.550.470'], ['G01.154.090.500', 'G02.111.820.580', 'G04.835.580'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['G08.686.784.769'], ['A04.760', 'A10.615.550.760'], ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of industrial hearing conservation programs: a review and analysis. | In 1981, a large scale reviews of the literature concerning the effects of noise on hearing was initiated by the National Institute of Neurological and Communicative Diseases and Stroke. This review concentrated on the information published in the decade of the 1970's and underscored the importance of evaluating the ef... | ['Evaluation Studies as Topic', 'Hearing Loss, Noise-Induced', 'Humans', 'Maximum Allowable Concentration', 'Noise', 'Noise, Occupational', 'Occupational Health Services', 'United States', 'United States Occupational Safety and Health Administration'] | 6,464,993 | [['E05.337', 'N05.715.360.335'], ['C09.218.458.341.887.460', 'C10.597.751.418.341.887.460', 'C23.888.592.763.393.341.887.460'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.210', 'N06.850.460.350.600.615'], ['G01.750.770.776.567', 'G16.500.275.600', 'N06.230.400', 'N06.850.460.610'], ['N06.230.400... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Improving the quality of electron tomography image volumes using pre-reconstruction filtering. | Electron tomography produces highly magnified 3D image volumes useful for investigating the structure and function of cellular components. Image quality is degraded by multiple scattering events and quantum noise, which depend on the angle at which individual tilt projections are collected. We have adapted a biomedical... | ['Algorithms', 'Anisotropy', 'Electron Microscope Tomography', 'Erythrocytes', 'Humans', 'Imaging, Three-Dimensional', 'Plasmodium berghei', 'Plasmodium falciparum', 'Quality Improvement', 'Signal-To-Noise Ratio', 'Sporozoites'] | 22,683,346 | [['G17.035', 'L01.224.050'], ['G01.590.040', 'G02.050'], ['E01.370.350.825.249', 'E05.595.402.580.239'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['B01.043.075.380.611.461'], ['B01.043.075.380.611.561'], ['J01.293.754', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Bimolecular complementation defines functional regions of Herpes simplex virus gB that are involved with gH/gL as a necessary step leading to cell fusion. | Herpes simplex virus (HSV) entry into cells requires four membrane glycoproteins: gD is the receptor binding protein, and gB and gH/gL constitute the core fusion machinery. Crystal structures of gD and its receptors have provided a basis for understanding the initial triggering steps, but how the core fusion proteins f... | ['Animals', 'Binding Sites', 'Cell Line', 'Chlorocebus aethiops', 'Cricetinae', 'Mice', 'Models, Molecular', 'Protein Interaction Domains and Motifs', 'Protein Structure, Tertiary', 'Simplexvirus', 'Viral Envelope Proteins', 'Virus Internalization'] | 20,130,048 | [['B01.050'], ['G02.111.570.120'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595'], ['G02.111.570.820.709.275.750.500'], ['G02.111.570.820.709.610'], ['B04.280.382.100.750'], ['D09.400.430... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. | Normally growing cells promptly cease DNA synthesis when exposed to genotoxic stresses, such as radiation, and this cell-cycle arrest prevents the accumulation of mutations. The transcription factor interferon regulatory factor (IRF)-1 is essential for the regulation of the interferon system, inhibits cell growth, and ... | ['Animals', 'Cell Cycle', 'Cyclin-Dependent Kinase Inhibitor p21', 'Cyclin-Dependent Kinases', 'Cyclins', 'DNA Damage', 'DNA-Binding Proteins', 'Gamma Rays', 'Gene Expression Regulation', 'Interferon Regulatory Factor-1', 'Mice', 'Mutation', 'Phosphoproteins', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Transcripti... | 8,752,276 | [['B01.050'], ['G04.144'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['D08.811.913.696.620.682.700.646.500', 'D12.644.360.250', 'D12.776.167.200', 'D12.776.476.250'], ['D12.644.360.262', 'D12.776.167.218', 'D12.776.476... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structure activity relationship of phosphoramidon derivatives for in vivo endothelin-converting-enzyme inhibition. | The structure activity relationship of phosphoramidon analogues was studied for their ability to reduce the hypertensive effect of exogenous proET-1, probably via inhibition of an endothelin converting enzyme activity (ECE). Results concerning in vivo ECE and in vitro thermolysin inhibitions were compared. In contrast ... | ['Animals', 'Aspartic Acid Endopeptidases', 'Blood Pressure', 'Dose-Response Relationship, Drug', 'Endothelin-1', 'Endothelin-Converting Enzymes', 'Endothelins', 'Glycopeptides', 'Male', 'Metalloendopeptidases', 'Neprilysin', 'Protein Precursors', 'Rats', 'Rats, Sprague-Dawley', 'Structure-Activity Relationship', 'Ther... | 8,020,872 | [['B01.050'], ['D08.811.277.656.074.500', 'D08.811.277.656.300.048'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['D08.811.277.656.074.500.270', 'D08.811.277.656.300.048.270', 'D08.811.277.656.300.480.229', 'D08.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reactions of type II restriction endonucleases with 8-base pair recognition sites. | Type II restriction endonucleases usually recognize 4-6-base pair (bp) sites on DNA and cleave each site in a separate reaction. A few type II endonucleases have 8-bp recognition sites, but these seem unsuited for restriction, since their sites are rare on most DNA. Moreover, only one endonuclease that recognizes a tar... | ['Base Pairing', 'Binding Sites', 'DNA', 'Deoxyribonucleases, Type II Site-Specific', 'Plasmids', 'Sequence Analysis', 'Substrate Specificity'] | 10,593,932 | [['G02.111.570.820.486.100', 'G02.111.611.500', 'G05.360.580.100'], ['G02.111.570.120'], ['D13.444.308'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['G05.360.600'], ['E05.393.760'], ['G02.111.835']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vaspar broth-disk procedure for antibiotic susceptibility testing of anaerobic bacteria. | A modification of the Wilkins-Thiel broth-disk procedure for antibiotic susceptibility testing of anaerobic bacteria is described. This method utilizes an aerobically prepared medium overlaid with molten vaspar. Specialized anaerobic techniques or prereduced media are not required. | ['Anaerobiosis', 'Bacteria', 'Culture Media', 'Microbial Sensitivity Tests', 'Oxygen'] | 7,387,149 | [['G02.111.062', 'G03.078'], ['B03'], ['D27.720.470.305', 'E07.206'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['D01.268.185.550', 'D01.362.670']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vasopressin-induced contraction in the rat basilar artery in vitro. | Vasopressin ([Arg(8)]vasopressin)-induced contraction was characterized using receptor agonists and antagonists for vasopressin and channel blockers in the rat basilar artery ring preparations. Vasopressin induced rhythmic contractions superimposed on a contraction in endothelium-intact preparations but not in denuded ... | ['Animals', 'Antidiuretic Hormone Receptor Antagonists', 'Apamin', 'Basilar Artery', 'Calcium', 'Charybdotoxin', 'Dose-Response Relationship, Drug', 'Endothelium, Vascular', 'Imidazoles', 'In Vitro Techniques', 'Male', 'Potassium Chloride', 'Rats', 'Rats, Wistar', 'Receptors, Vasopressin', 'Vasoconstriction', 'Vasodila... | 11,282,120 | [['B01.050'], ['D27.505.519.174', 'D27.505.696.560.311'], ['D20.888.065.115.060', 'D23.946.833.065.115.060'], ['A07.015.114.106'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.115', 'D20.888.065.830.150', 'D23.946.833.065.830.150'], ['G07.690.773.875', 'G07.690.936.500'], ['A07.015.700.500', 'A10.27... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of primers designed for the subspecies-specific discrimination among Babesia canis canis, Babesia canis vogeli and Babesia canis rossi by PCR assay. | Canine babesiosis is an infectious disease caused by either Babesia gibsoni or Babesia canis protozoans. The latter is also classified under three different phylogenetic groups, referred to as subspecies B. canis canis, B. canis vogeli and B. canis rossi. The objective of the present study was to validate and standardi... | ['Animals', 'Babesia', 'Babesiosis', 'Base Sequence', 'DNA Primers', 'DNA, Protozoan', 'DNA, Ribosomal Spacer', 'Dog Diseases', 'Dogs', 'Molecular Sequence Data', 'Molecular Weight', 'Phylogeny', 'Polymerase Chain Reaction', 'RNA, Ribosomal', 'Sensitivity and Specificity', 'Sequence Alignment', 'Species Specificity'] | 18,242,863 | [['B01.050'], ['B01.043.075.600.580.070'], ['C01.610.701.688.122', 'C01.610.752.075', 'C01.610.752.625.122', 'C01.920.930.182', 'C22.674.710.122'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.442'], ['D13.444.308.324.230', 'D13.444... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats. | The nasal absorption of zidovudine (AZT) and its subsequent transport to cerebrospinal fluid (CSF) was examined in rats. Both rapid absorption and a high CSF concentration were observed after the nasal application. Plasma and CSF concentrations of AZT increased when probenecid was coadministered with AZT. Thus, this na... | ['Administration, Intranasal', 'Animals', 'Male', 'Nasal Mucosa', 'Probenecid', 'Rats', 'Rats, Wistar', 'Zidovudine'] | 7,820,125 | [['E02.319.267.120.655.500'], ['B01.050'], ['A04.531.520', 'A04.760.600', 'A10.615.550.760.600'], ['D02.065.884.625', 'D02.886.590.700.625'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D03.383.742.680.705.950', 'D13.570.230.500.950', 'D13.570.230.855.950', 'D13.570.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular characterization of human gastric mucosa by HR-MAS magnetic resonance spectroscopy. | The present study was aimed at identifying the molecular profile characteristic of the healthy human gastric mucosa. Ex vivo HR-MAS magnetic resonance spectroscopy performed at 9.4 Tesla (400.13 MHz for (1)H) on gastric specimens collected during endoscopy, permits the identification of more than forty species giving a... | ['Biopsy', 'Gastric Mucosa', 'Humans', 'Magnetic Resonance Spectroscopy'] | 15,547,675 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Frequency of methicilin-resistant Staphylococcus aureus strains in clinical spacimens obtained from hospitalized patients in 2007]. | INTRODUCTION: Staphylococcus aureus is a major cause of both hospital- and community-acquired infections worldwide. Since the introduction of methicillin into clinical use, methicillin-resistant S. aureus strains have emerged with increasing frequency throughout the world. The aim of the study was to determine frequenc... | ['Drug Resistance, Bacterial', 'Humans', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivity Tests', 'Staphylococcal Infections'] | 19,256,065 | [['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.300.390.400.800.750.100.500', 'B03.353.500.750.750.100.500', 'B03.510.100.750.750.100.500', 'B03.510.400.790.750.100.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['C01.150.252.410.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Smoking reduction intervention in a large population-based study. The Inter99 study. | BACKGROUND: Smoking reduction has been introduced as an alternative to smokers unable or unwilling to quit but has never been implemented in a population-based intervention.METHODS: Two thousand four hundred eight daily smokers in all motivational stages were included in a randomised population-based intervention study... | ['Adult', 'Attitude to Health', 'Denmark', 'Humans', 'Life Style', 'Middle Aged', 'Motivation', 'Smoking', 'Smoking Cessation', 'Smoking Prevention'] | 15,530,588 | [['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['Z01.542.816.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['F01.145.805'], ['F01.145.488.732'], ['I02.233.332.812', 'N02.421.726.407.840']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Impact of infrared treatment on quality and fungal decontamination of mung bean (Vigna radiata L.) inoculated with Aspergillus spp. | BACKGROUND: Mung bean is a rich source of protein, carbohydrates and fiber content. It also exhibits a high level of antioxidant activity due to the presence of phenolic compounds. Aspergillus flavus and A. niger are the two major fungal strains associated with stored mung bean that lead to post-harvest losses of grain... | ['Aspergillus flavus', 'Aspergillus niger', 'Food Contamination', 'Food Irradiation', 'Infrared Rays', 'Plant Diseases', 'Seeds', 'Spores, Fungal', 'Vigna'] | 29,119,563 | [['B01.300.381.081.170'], ['B01.300.381.081.450'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['J01.576.423.850.700.700.500'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.400', 'N06.230.3... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Outcome, functional recovery and unmet needs following acute stroke. Experience of patient follow up at 6 to 9 months in a newly established stroke service. | OBJECTIVE: To assess outcome at six months post stroke and the unmet needs and adherence to the secondary prevention advice among survivors living at home.SETTING: Stroke Rehabilitation Unit (SRU), Hairmyres Hospital and patients homes.SUBJECTS: Survivors living at home who had been managed in the SRU.RESULTS: Of 572 c... | ['Activities of Daily Living', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Hospital Units', 'Humans', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Patient Education as Topic', 'Recovery of Function', 'Rehabilitation Centers', 'Stroke Rehabilitation'] | 12,616,970 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N02.278.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['I02.233.332.500', 'N02.421... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Angiopoietin-1-expressing adipose stem cells genetically modified with baculovirus nanocomplex: investigation in rat heart with acute infarction. | The objective of this study was to develop angiopoietin-1 (Ang1)-expressing genetically modified human adipose tissue derived stem cells (hASCs) for myocardial therapy. For this, an efficient gene delivery system using recombinant baculovirus complexed with cell penetrating transactivating transcriptional activator TAT... | ['Adipocytes', 'Angiopoietin-1', 'Animals', 'Baculoviridae', 'Cell Growth Processes', 'Cell Survival', 'Genetic Therapy', 'Humans', 'Male', 'Myocardial Infarction', 'Nanoparticles', 'Rats', 'Stem Cell Transplantation', 'Stem Cells', 'Stroke Volume', 'Tissue Engineering', 'Transgenes', 'Wound Healing'] | 22,334,788 | [['A11.329.114'], ['D12.644.276.100.100.100', 'D12.776.467.100.100.100', 'D23.529.100.100.100'], ['B01.050'], ['B04.280.065', 'B04.525.100'], ['G04.161', 'G07.345.249.410'], ['G04.346'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Familial megacecum and colon in the rat: a new model of gastrointestinal neuromuscular dysfunction. | Gastrointestinal motility disorders are of considerable clinical importance in humans and animals. Abnormalities of smooth muscle and the enteric nervous system have been described. We have identified and characterized a new mutant stock of rats that develops severe megacecum and colon with pseudo-obstruction, Familial... | ['Animals', 'Biomarkers', 'Breeding', 'Cecum', 'Colon', 'Disease Models, Animal', 'Female', 'Gastrointestinal Transit', 'Hirschsprung Disease', 'Immunoenzyme Techniques', 'Male', 'Muscle Contraction', 'Muscle, Smooth', 'Myenteric Plexus', 'Pedigree', 'Radiography', 'Rats', 'Rats, Mutant Strains', 'Rats, Sprague-Dawley'... | 10,090,023 | [['B01.050'], ['D23.101'], ['E05.820.150', 'G05.090'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.372.310', 'G10.261.360.525'], ['C06.198.439', 'C06.405.469.158.701.439', 'C16.131.314.439'], ['E05.478.566.350',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uni- and triaxial accelerometric signals agree during daily routine, but show differences between sports. | Accelerometers objectively monitor physical activity, and ongoing research suggests they can also detect patterns of body movement. However, different types of signal (uniaxial, captured by older studies, vs. the newer triaxial) and or/device (validated Actigraph used by older studies, vs. others) may lead to incompara... | ['Accelerometry', 'Adolescent', 'Female', 'Humans', 'Male', 'Sports'] | 30,305,651 | [['E05.003'], ['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450.642.845']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Current incidence and residual risk of HIV, HBV and HCV at Canadian Blood Services. | Estimates of the viral residual risk should be updated to reflect current incidence of infection in blood donors. Incidence rates were estimated for allogeneic whole-blood donations made to Canadian Blood Services from 2006 to 2009 based on transmissible disease conversions of repeat donations within a 3-year period. R... | ['Blood Donors', 'Blood Transfusion', 'Canada', 'HIV Infections', 'HIV-1', 'HIV-2', 'Hepacivirus', 'Hepatitis B', 'Hepatitis B virus', 'Hepatitis C', 'Humans', 'Incidence', 'Risk Factors', 'Transfusion Reaction'] | 22,289,147 | [['M01.898.313'], ['E02.095.135'], ['Z01.107.567.176'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B04.820.650.589.650.350.410'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.500', 'C01.925.256.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Optimal dietary alcoholic extract of lotus leaf improved growth performance and health status of grass carp (Ctenopharyngodon idellus). | Grass carp (Ctenopharyngodon idellus) is one of the most important aquaculture fish in China. This study tried to explore the effects of dietary alcoholic extract of lotus leaf (AELL) addition on the growth performance and health status of grass carp by feeding juvenile fish (average weight: 34 ± 1 g) with four differe... | ['Animal Feed', 'Animals', 'Blood Chemical Analysis', 'Carps', 'Diet', 'Dietary Supplements', 'Dose-Response Relationship, Drug', 'Female', 'Male', 'Nelumbo', 'Plant Extracts', 'Random Allocation'] | 31,315,061 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['E01.370.225.124.100', 'E05.200.124.100'], ['B01.050.150.900.493.200.244.248'], ['G07.203.650.240'], ['G07.203.300.456', 'J02.500.456'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.650.940.800.575.912.250.774.500'], ['D20.215.784.500', 'D26.667'], ['E05.318.3... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Glomangioma of the trachea. | A case of a glomus tumor arising in an unusual site, the trachea, is described. The tumor was composed of a mixture of glomus cells and mast cells. At the ultrastructural level, the glomus cells exhibited features of modified smooth-muscle cells. | ['Basement Membrane', 'Cytoplasm', 'Epithelium', 'Female', 'Glomus Tumor', 'Humans', 'Microscopy, Electron', 'Middle Aged', 'Tracheal Neoplasms'] | 6,247,060 | [['A10.272.220', 'A10.615.179'], ['A11.284.430.214'], ['A10.272'], ['C04.557.645.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['M01.060.116.630'], ['C04.588.443.925', 'C04.588.894.797.760', 'C08.785.760', 'C08.907.563']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lung ultrasound-a new diagnostic modality in persistent tachypnea of infancy. | Lung ultrasound (LUS) has been increasingly used in diagnosing and monitoring of various pulmonary diseases in children. The aim of the current study was to evaluate its usefulness in children with persistent tachypnea of infancy (PTI). This was a controlled, prospective, cross-sectional study that included children wi... | ['Child', 'Cross-Sectional Studies', 'Female', 'Humans', 'Lung', 'Lung Diseases', 'Male', 'Pleura', 'Prospective Studies', 'Tachypnea', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 31,978,279 | [['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.381'], ['A04.716', 'A10.615.789.736'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['C08.618.961', 'C23.888.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lid lag and lagophthalmos: a clarification of terminology. | Lid lag, lagophthalmos and von Grafe's sign are useful terms which refer to important clinical signs. Despite the fact that they have discrete meanings, they are often used interchangeably and incorrectly by many ophthalmologists and, therefore, their value has been degraded. We provide definitions for these commonly u... | ['Blepharoptosis', 'Child', 'Eyelid Diseases', 'Humans', 'Keratitis', 'Terminology as Topic'] | 7,266,976 | [['C11.338.204'], ['M01.060.406'], ['C11.338'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.564'], ['L01.559.598.400']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Depression and stress management in medical students. A comparative study between freshman and advanced medical students]. | International studies have indicated a high prevalence of depression and a lack of coping with stress in medical students. Freshman and advanced medical students were investigated using a specific questionnaire and the Beck Depression Inventory (BDI) with a response rate of 100%. Of the subjects studied 81.1% did not h... | ['Adaptation, Psychological', 'Alcohol Drinking', 'Depressive Disorder', 'Female', 'Humans', 'Leisure Activities', 'Life Style', 'Male', 'Personal Satisfaction', 'Risk Factors', 'Sex Factors', 'Social Environment', 'Social Support', 'Stress, Psychological', 'Students, Medical', 'Substance-Related Disorders', 'Work Sche... | 21,165,590 | [['F01.058'], ['F01.145.317.269'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450'], ['F01.829.458'], ['F01.145.677'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['N05.715.350.675', 'N06.850.490.87... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Enhancement of HIV-1 replication in peripheral blood mononuclear cells by Cryptococcus neoformans is monocyte-dependent but tumour necrosis factor-independent. | OBJECTIVE: To investigate the possible role of Cryptococcus neoformans in HIV-1 pathogenesis.DESIGN: An in vitro system was developed to study HIV-1 replication in freshly HIV-1-infected peripheral blood mononuclear cells (PBMC) incubated with whole azide-killed C. neoformans.METHODS: Human PBMC or peripheral blood lym... | ['Antibodies, Monoclonal', 'Cells, Cultured', 'Cryptococcus neoformans', 'HIV-1', 'Humans', 'Monocytes', 'Pentoxifylline', 'Tumor Necrosis Factor-alpha', 'Virus Replication'] | 8,011,245 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.251'], ['B01.300.381.258.366', 'B01.300.930.316.366'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547', 'A15.145.229... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ferric chloride based downstream process for microalgae based biodiesel production. | In this study, ferric chloride (FeCl3) was used to integrate downstream processes (harvesting, lipid extraction, and esterification). At concentration of 200 mg/L and at pH 3, FeCl3 exhibited an expected degree of coagulation and an increase in cell density of ten times (170 mg/10 mL). An iron-mediated oxidation reacti... | ['Biofuels', 'Biotechnology', 'Chlorella', 'Chlorides', 'Chromatography, Gas', 'Esterification', 'Ferric Compounds', 'Hydrogen Peroxide', 'Hydrogen-Ion Concentration', 'Iron', 'Lipids', 'Microalgae', 'Static Electricity'] | 25,647,024 | [['D20.147', 'N06.230.132.644.124'], ['H01.158.550', 'J01.897.120'], ['B01.650.940.150.469'], ['D01.210.450.150', 'D01.248.497.158.215'], ['E05.196.181.349'], ['G02.111.270', 'G02.607.250', 'G03.344'], ['D01.490.100'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['G... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
[Nursing as an option: profile of undergraduate of two teaching institutions]. | This is a descriptive-exploratory study, aiming at comparing socioeconomic profile of students of two teaching institutions of the municipality of Rio de Janeiro and factors that interfere in their option to choose Nursing. The study was composed by 152 students of Institution (A) and 120 of (B) who were admitted to th... | ['Adolescent', 'Adult', 'Brazil', 'Career Choice', 'Female', 'Humans', 'Male', 'Nursing', 'Schools, Nursing', 'Socioeconomic Factors', 'Students, Nursing'] | 18,572,835 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['F02.463.785.373.346.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.478', 'N04.452.758.377'], ['I02.783.495.623'], ['I01.880.853.996', 'N01.824'], ['M01.848.769.685']] | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Changes of abdominal temperature and circulating levels of cortisol and interleukin-6 in response to intra-arterial infusions of tumor necrosis factor-alpha or tumor necrosis factor-beta in guinea pigs. | The sister proteins tumor necrosis factor (TNF)-alpha and TNF-beta share 35% of their amino acid sequence and a number, but not all, of their biological properties. In the present study we infused amounts of 5 microg/kg TNF-alpha, TNF-beta (both preparations with identical bioactivities) or of solvent (0.9% sterile sal... | ['Animals', 'Body Temperature', 'Guinea Pigs', 'Hydrocortisone', 'Hypothalamus', 'Infusions, Intra-Arterial', 'Interleukin-6', 'Lymphotoxin-alpha', 'Male', 'Pituitary-Adrenal System', 'Tumor Necrosis Factor-alpha'] | 9,369,355 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['B01.050.150.900.649.313.992.550'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['E02.319.267.510.520'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.4... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondrial changes induced by natural and synthetic asbestos fibers: studies on isolated mitochondria. | Asbestos fibers, such as chrysotile and crocidolite, are known to have cytotoxic effects on different cell types. In vivo exposure to asbestos fibers can induce both fibrotic and malignant lung diseases , however, the mechanisms linking exposure to the subsequent development of the diseases are unknown. Numerous invest... | ['Animals', 'Asbestos, Crocidolite', 'Calcium', 'Cell Membrane Permeability', 'Electron Transport Complex IV', 'Mitochondria', 'Reactive Oxygen Species'] | 17,543,227 | [['B01.050'], ['D01.578.725.050.050.100', 'D01.837.725.700.760.070.050.090'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G03.143.335', 'G04.175'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776.543.585.450.250.875.484'], ['A... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comprehensive proteome analysis of ovarian cancers using liquid phase separation, mass mapping and tandem mass spectrometry: a strategy for identification of candidate cancer biomarkers. | A two-dimensional (2-D) liquid phase separation method, liquid isoelectric focusing followed by nonporous reversed-phase high performance liquid chromatography (HPLC), was used to separate proteins from human ovarian epithelial whole cell lysates. HPLC eluent was interfaced on-line to an electrospray ionization (ESI) t... | ['Biomarkers, Tumor', 'Cell Line, Tumor', 'Chromatography, High Pressure Liquid', 'Female', 'Humans', 'Isoelectric Focusing', 'Molecular Sequence Data', 'Neoplasm Proteins', 'Ovarian Neoplasms', 'Peptide Mapping', 'Proteome', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 15,274,142 | [['D23.101.140'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.401.663', 'E05.301.300.663'], ['L01.453.245.667'], ['D12.776.624'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['E05... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Study of efavirenz over 96 weeks shows durability, efficacious regimen. Results from 48-96 weeks essentially same. | Recent results from the Daily Antiretroviral Therapy (DART 1) trial show promising results for antiretroviral na?ve patients. The 96-week study results from 65 patients who were treated with the combination of once-daily efavirenz (600 mg), lamivudine (300 mg), and didanosine (400 mg) showed that the rates of patients ... | ['Alkynes', 'Benzoxazines', 'Cyclopropanes', 'HIV Infections', 'Humans', 'Oxazines', 'RNA, Viral', 'Reverse Transcriptase Inhibitors', 'Viral Load'] | 16,562,339 | [['D02.455.326.397'], ['D03.383.533.249', 'D03.633.100.209'], ['D02.455.426.392.368.533'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.533'], ['D13.444.735.828'], ['D27.505.519.389.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel model of HPV infection in meshed human foreskin grafts. | The present study describes a novel meshing procedure that provided successful low-risk papillomavirus propagation and reproducible wart induction in human foreskin xenografts. The initial HPV6 and/or 11 inocula were collected from clinically excised human wart tissues and confirmed to be free of HPV16, 18 and 31 by PC... | ['Animals', 'Cell Transformation, Viral', 'Fibroblasts', 'Humans', 'Mice', 'Mice, Nude', 'Models, Animal', 'Papilloma', 'Papillomaviridae', 'Papillomavirus Infections', 'Skin Transplantation', 'Transplantation, Heterologous'] | 15,550,271 | [['B01.050'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['E05.598'], ['C04.557.470.700.600'], ['B04.280.210.655', 'B04.613.204.655'... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An evaluation of Birmingham Own Health telephone care management service among patients with poorly controlled diabetes. A retrospective comparison with the General Practice Research Database. | BACKGROUND: Telephone-based care management programmes have been shown to improve health outcomes in some chronic diseases. Birmingham Own Health is a telephone-based care service (nurse-delivered motivational coaching and support for self-management and lifestyle change) for patients with poorly controlled diabetes, d... | ['Aged', 'Alabama', 'Databases, Factual', 'Diabetes Mellitus', 'Disease Management', 'Female', 'General Practice', 'Humans', 'Male', 'Middle Aged', 'Research', 'Retrospective Studies', 'Self Care', 'Telecommunications', 'Telemedicine', 'Treatment Outcome', 'United Kingdom'] | 21,929,804 | [['M01.060.116.100'], ['Z01.107.567.875.075.100', 'Z01.107.567.875.750.100'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['C18.452.394.750', 'C19.246'], ['N04.590.607'], ['H02.403.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644'], ['E05.318.372.500.500.500', 'E05.318.... | ['Named Groups [M]', 'Geographicals [Z]', 'Information Science [L]', 'Diseases [C]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Doppler features of occlusion of the internal thoracic artery due to preoperative branch embolization. | A 61-year-old male was referred to the surgical ward by cardiologists because of a diagnosis of unstable angina with 3-vessel disease. On preoperative left internal thoracic arteriography, a large first intercostal branch was found at the proximal portion. Selective arterial embolization of the branch of the left inter... | ['Angina Pectoris', 'Contraindications', 'Echocardiography, Doppler, Pulsed', 'Embolization, Therapeutic', 'Graft Occlusion, Vascular', 'Humans', 'Male', 'Middle Aged', 'Thoracic Arteries', 'Thrombosis'] | 10,553,929 | [['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['E02.208'], ['E01.370.350.130.750.220.225', 'E01.370.350.850.220.220.225', 'E01.370.350.850.850.220.225', 'E01.370.350.850.850.860.225', 'E01.370.370.380.220.220.225'], ['E02.520.360', 'E02.926.500'], ['C23.550.767.400'], ['B01.050.150.900.649.313.988... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Studies on ammocytes: development, metabolic characteristics, and detoxication of ammonium. | The possibility of reducing ammonium concentration in the blood of mice with hyperammonemia with ammocytes (erythrocytes loaded with glutamate synthase) and the metabolic characteristics of these cells were studied. Injection of ammocytes into the blood stream of animals with hyperammonemia led to reduction of the bloo... | ['Animals', 'Cell- and Tissue-Based Therapy', 'Erythrocytes', 'Glucosephosphate Dehydrogenase', 'Glutamate Synthase', 'Hexokinase', 'Hyperammonemia', 'L-Lactate Dehydrogenase', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Phosphofructokinases', 'Pyruvate Kinase', 'Quaternary Ammonium Compounds'] | 19,513,368 | [['B01.050'], ['E02.095.147'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D08.811.682.047.150.300'], ['D08.811.682.664.500.470', 'D08.811.913.477.700.470'], ['D08.811.913.696.620.300'], ['C23.550.421'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Associations of ChREBP and Global DNA Methylation with Genetic and Environmental Factors in Chinese Healthy Adults. | Age, gender, diet, gene and lifestyle have been reported to affect metabolic status and disease susceptibility through epigenetic pathway. But it remains indistinct that which factors account for certain epigenetic modifications. Our aim was to identify the influencing factors on inter-individual DNA methylation variat... | ['Adult', 'Basic Helix-Loop-Helix Leucine Zipper Transcription Factors', 'Cholesterol, HDL', 'Cholesterol, LDL', 'DNA (Cytosine-5-)-Methyltransferase 1', 'DNA (Cytosine-5-)-Methyltransferases', 'DNA Methylation', 'Environment', 'Epigenesis, Genetic', 'Female', 'Genotype', 'Haplotypes', 'Humans', 'Lipids', 'Male', 'Midd... | 27,281,235 | [['M01.060.116'], ['D12.776.260.103.500', 'D12.776.260.108.092', 'D12.776.930.125.500', 'D12.776.930.127.092'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['D08.811.91... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is there a selective relationship between language functioning and auditory attention in children? | This study explores the selectivity of the relationship between auditory attention and language in children. A total of 42 children (16 females) between 7.0 and 10.0 years of age were administered a battery of cognitive, language, and behavioral measures along with 3 auditory and 3 visual continuous performance tests (... | ['Acoustic Stimulation', 'Attention', 'Auditory Perception', 'Child', 'Female', 'Humans', 'Language', 'Language Development', 'Male', 'Multivariate Analysis', 'Neuropsychological Tests', 'Photic Stimulation', 'Reaction Time'] | 17,691,039 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['F02.830.104.214'], ['F02.463.593.071', 'G07.888.125'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F01.525.200.310'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['F04.711.513'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
EVAR with Aortic Placement of a Single JOTEC E-iliac Stent-graft System in a Patient with Poliomyelitis Aortoiliac Deformities. | Small-sized vessels can represent a contraindication to standard endovascular aortic repair (EVAR), and more specifically, aortoiliac deformities resulting from poliomyelitis may add an adjunctive challenge for total endovascular repair. Herein we report a case of a 62-year-old man with a 55 mm abdominal aortic aneurys... | ['Aged', 'Aorta, Abdominal', 'Aortic Aneurysm, Abdominal', 'Atrophy', 'Blood Vessel Prosthesis', 'Blood Vessel Prosthesis Implantation', 'Endovascular Procedures', 'Humans', 'Iliac Artery', 'Male', 'Poliomyelitis', 'Stents', 'Treatment Outcome'] | 32,768,550 | [['M01.060.116.100'], ['A07.015.114.056.205'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['C23.300.070'], ['E07.695.110'], ['E04.100.814.868.500', 'E04.650.200'], ['E04.100.814.529', 'E04.502.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.444'], ['C01.207.618.750', 'C01.925.782.687.359.764'... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
New example of proline-induced fragmentation in electrospray ionization mass spectrometry of peptides. | The positive ion electrospray ionization (ESI+) mass spectra of peptides usually display only protonated molecules provided that soft ionization conditions are applied (low cone voltage to prevent in-source dissociations). Such ions can be multiply charged depending on the molecular weight of the studied compounds. We ... | ['Amino Acids', 'Calibration', 'Molecular Weight', 'Peptides', 'Proline', 'Spectrometry, Mass, Electrospray Ionization', 'Spectrophotometry, Ultraviolet'] | 12,125,024 | [['D12.125'], ['E05.978.155'], ['G02.494'], ['D12.644'], ['D12.125.072.401.623'], ['E05.196.566.600'], ['E05.196.712.726.802', 'E05.196.867.826.802']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of Interleukin-33 in the modulation of splenic T-cell immune responses after experimental ischemic stroke. | The splenic T-cell immune response to stroke has been identified as an important role in the progression of brain injury following ischemic stroke. Interleukin (IL)-33 as a novel cytokine of IL-1 family has been found to be protective for ischemic brain injury. Here, we determined the contribution of IL-33 to the T-cel... | ['Animals', 'Atrophy', 'Infarction, Middle Cerebral Artery', 'Injections, Intraperitoneal', 'Interleukin-33', 'Ischemic Attack, Transient', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Premedication', 'Random Allocation', 'Recombinant Proteins', 'Spleen', 'T-Lymphocyte Subsets', 'T-Lymphocytes, Regulatory', 'Th1 Cells', 'Tra... | 31,146,104 | [['B01.050'], ['C23.300.070'], ['C10.228.140.300.150.477.200.450', 'C10.228.140.300.510.200.387', 'C10.228.140.300.775.200.200.450', 'C14.907.253.092.477.200.450', 'C14.907.253.560.200.387', 'C14.907.253.855.200.200.450', 'C23.550.513.355.250.200.450', 'C23.550.717.489.250.200.450'], ['E02.319.267.530.490'], ['D12.644.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. | Silencing of interleukin-32 (IL-32) in a differentiated human promonocytic cell line impairs killing of Mycobacterium tuberculosis (MTB) but the role of IL-32 in vivo against MTB remains unknown. To study the effects of IL-32 in vivo, a transgenic mouse was generated in which the human IL-32ã gene is expressed using th... | ['Adaptive Immunity', 'Animals', 'Antigens, Ly', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Cells, Cultured', 'Humans', 'Immunity, Innate', 'Interferon-gamma', 'Interleukins', 'Lung', 'Lymph Nodes', 'Macrophages, Alveolar', 'Mice, Transgenic', 'Mutation', 'Mycobacterium tuberculosis', 'NK Cell Lectin-... | 25,820,174 | [['G12.450.050'], ['B01.050'], ['D23.050.301.264.920', 'D23.101.100.920'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['A11.251'], ['B01.050.150.900.649.313.988.400.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of ultrasound to locate a "lost" tissue expander injection port. | We have presented a rapid and reliable method of finding lost injection valves. (A frustrating footnote, however, is that 1 week later the port had again migrated and could not be located. Since the further anticipated gain was marginal, the bladder was already nearly expanded, and the expense for repeated ultrasound w... | ['Aged', 'Female', 'Humans', 'Surgery, Plastic', 'Ultrasonics'] | 3,725,974 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.810.788'], ['H01.671.031.849']] | ['Named Groups [M]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
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