Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Peripheral phosphodiesterase 4 inhibition produced by 4-[2-(3,4-Bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl]-3-methylpyridine-1-oxide (L-826,141) prevents experimental autoimmune encephalomyelitis. | Administration of phosphodiesterase 4 (PDE4) inhibitors suppresses the pathogenesis associated with experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). In the present study, we compared the effects of rolipram and 4-[2-(3,4-bis-difluoromethoxyphenyl)-2-[4-(1,1,1,3,3,3-hexafluoro... | ["3',5'-Cyclic-AMP Phosphodiesterases", 'Animals', 'Body Weight', 'Cyclic Nucleotide Phosphodiesterases, Type 4', 'Encephalomyelitis, Autoimmune, Experimental', 'Glial Fibrillary Acidic Protein', 'Lipopolysaccharides', 'Mice', 'Mice, Inbred C57BL', 'Multiple Sclerosis', 'Phosphodiesterase Inhibitors', 'Proto-Oncogene P... | 16,809,479 | [['D08.811.277.352.640.150', 'D12.644.360.008', 'D12.776.476.008'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D08.811.277.352.640.150.400', 'D12.644.360.008.400', 'D12.776.476.008.400'], ['C10.114.703.300', 'C10.228.140.695.562.25... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. | Bloodstream form African trypanosomes are thought to rely exclusively upon glycolysis, using glucose as a substrate, for ATP production. Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. However, plasma membra... | ['Gluconeogenesis', 'Glycerol', 'Substrate Specificity', 'Trypanosoma brucei brucei'] | 30,589,893 | [['G02.111.158.500', 'G03.191.500'], ['D02.033.800.875.500', 'D09.853.875.500'], ['G02.111.835'], ['B01.268.475.868.887.080']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Incidence of ocular complications in rheumatoid arthritis and the relation of keratoconjunctivitis sicca with its systemic activity. | To investigate the incidence of ocular complications in patients with rheumatoid arthritis under modern modalities of treatment and find the relationship between its systemic activity and ocular complications, routine ophthalmological examinations were done as a prospective study in 111 consecutive patients including 8... | ['Adult', 'Aged', 'Arthritis, Rheumatoid', 'Eye Diseases', 'Female', 'Humans', 'Incidence', 'Keratoconjunctivitis Sicca', 'Male', 'Middle Aged', 'Prospective Studies', 'Rheumatoid Factor'] | 9,137,326 | [['M01.060.116'], ['M01.060.116.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C11.187.183.394.500', 'C11.204.564.58... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of acceleration on gait measures in three horse gaits. | Animals switch gaits according to locomotor speed. In terrestrial locomotion, gaits have been defined according to footfall patterns or differences in center of mass (COM) motion, which characterizes mechanisms that are more general and more predictive than footfall patterns. This has generated different variables desi... | ['Acceleration', 'Animals', 'Biomechanical Phenomena', 'Gait', 'Horses'] | 25,767,145 | [['G01.482.107'], ['B01.050'], ['G01.154.090', 'G01.374.089'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.984.235.472']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activation of hepatocytes by extracellular heat shock protein 72. | Heat shock protein (HSP) 72 is released by cells during stress and injury. HSP-72 also stimulates the release of cytokines in macrophages by binding to Toll-like receptors (TLR) 2 and 4. Circulating levels of HSP-72 increase during hepatic ischemia-reperfusion injury. The role of extracellular HSP-72 (eHSP-72) in the i... | ['Animals', 'Cells, Cultured', 'Chemokine CXCL2', 'Enzyme Inhibitors', 'HSP72 Heat-Shock Proteins', 'Hepatocytes', 'Humans', 'Immunohistochemistry', 'Interleukin-2', 'JNK Mitogen-Activated Protein Kinases', 'Liver', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Mutant Strains', 'Mutation', 'NF-kappa B', '... | 18,508,912 | [['B01.050'], ['A11.251'], ['D12.644.276.374.200.120.100', 'D12.644.276.374.200.600.940', 'D12.776.467.374.200.120.100', 'D12.776.467.374.200.600.940', 'D23.125.300.120.100', 'D23.125.300.600.940', 'D23.469.200.120.100', 'D23.469.200.600.940', 'D23.529.374.200.120.100', 'D23.529.374.200.600.940'], ['D27.505.519.389'], ... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease. | BACKGROUND: Small RNA molecules, called microRNAs, freely circulate in human plasma and correlate with varying pathologies. In this study, we explored their diagnostic potential in a selection of prevalent cardiovascular disorders.METHODS AND RESULTS: MicroRNAs were isolated from plasmas from well-characterized patient... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cardiovascular Diseases', 'Case-Control Studies', 'Humans', 'MicroRNAs', 'Middle Aged', 'Myocardium', 'Myocytes, Cardiac', 'Polymerase Chain Reaction', 'Severity of Illness Index'] | 20,921,333 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['M01.060.116.630'], ['A02.633.580', 'A07.541.70... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Toxicity of organic UV-filters to the aquatic midge Chironomus riparius. | Despite the frequent detection of organic ultraviolet-filters (UV-filters) in freshwater sediments, there is a lack of ecotoxicological data undermining a correct risk assessment for these emerging contaminants. The present study assessed the effects of three of the most commonly used UV-filters (benzophenone-3 - BP3; ... | ['Acetylcholinesterase', 'Acrylates', 'Animals', 'Benzophenones', 'Camphor', 'Catalase', 'Chironomidae', 'Female', 'Glutathione Transferase', 'Larva', 'Male', 'Sunscreening Agents', 'Water Pollutants, Chemical'] | 28,551,578 | [['D08.811.277.352.100.170.176'], ['D02.241.081.069'], ['B01.050'], ['D02.455.426.559.389.134', 'D02.522.223'], ['D02.455.426.100.080.050.500.326', 'D02.455.426.100.080.550.234.326', 'D02.455.849.575.141.500.326', 'D02.522.376', 'D04.075.080.500.234.326'], ['D08.811.682.732.332'], ['B01.050.500.131.617.720.500.500.750.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Automated localization of whales in coastal fjords. | Localization and tracking of vocalizing marine mammals are powerful tools for understanding and mitigating the impacts of anthropogenic stressors such as vessel noise on habitat use of cetaceans. A large-aperture hydrophone network has been installed in the Kitimat Fjord System, an ecologically, culturally, and economi... | ['Acoustics', 'Animals', 'Ecosystem', 'Estuaries', 'Fin Whale', 'Humpback Whale', 'Noise', 'Probability', 'Sound Localization', 'Vocalization, Animal', 'Whale, Killer'] | 31,893,735 | [['H01.671.031'], ['B01.050'], ['G16.500.275.157', 'N06.230.124'], ['G01.311.625.540'], ['B01.050.150.900.649.313.875.865.100.350'], ['B01.050.150.900.649.313.875.865.400'], ['G01.750.770.776.567', 'G16.500.275.600', 'N06.230.400', 'N06.850.460.610'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.8... | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Dual energy CT angiography: pros and cons of dual-energy metal artifact reduction algorithm in patients after endovascular aortic repair. | PURPOSE: To evaluate the value of metal artifact reduction (MAR) post-processing and iodine MD images in fast kV-switching dual-energy computed tomography (DECT) in patients after endovascular aortic repair (EVAR).MATERIALS AND METHODS: Twenty-four consecutive EVAR patients (age 76 ± 9 years, 7/24 (29%) with coils, 9/2... | ['Aged', 'Algorithms', 'Aortic Diseases', 'Artifacts', 'Blood Vessel Prosthesis', 'Computed Tomography Angiography', 'Contrast Media', 'Endovascular Procedures', 'Female', 'Humans', 'Iohexol', 'Male', 'Metals', 'Radiographic Image Interpretation, Computer-Assisted', 'Radiography, Dual-Energy Scanned Projection', 'Retro... | 27,896,386 | [['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['C14.907.109'], ['E05.047'], ['E07.695.110'], ['E01.370.350.350.810.335', 'E01.370.350.567.250', 'E01.370.350.600.350.700.810.335', 'E01.370.350.700.700.810.335', 'E01.370.350.700.810.810.568', 'E01.370.350.825.810.810.499'], ['D27.505.259.500', 'D27.720.259'], ['E04.1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Exploring Mitochondria-Mediated Intrinsic Apoptosis by New Phytochemical Entities: An Explicit Observation of Cytochrome c | Hydnocarpin (Hy) is a flavonoid isolated and purified from the seeds of Hydnocarpus wightiana Blume. Herein, we have developed a built-in semi-synthetic modification on Hy by one-pot multi-component reaction and a [3 + 2] cycloaddition strategy to append five membered isoxazole and isoxazolone as new phytochemical enti... | ['Antineoplastic Agents', 'Apoptosis', 'Cell Proliferation', 'Cycloaddition Reaction', 'Cytochromes c', 'Dose-Response Relationship, Drug', 'Drug Screening Assays, Antitumor', 'Flavonolignans', 'Humans', 'Lung Neoplasms', 'Melanoma', 'Membrane Potential, Mitochondrial', 'Mitochondria', 'Molecular Structure', 'Structure... | 31,393,121 | [['D27.505.954.248'], ['G04.146.954.035'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.197.406', 'J01.897.836.249.374'], ['D08.244.286.100', 'D12.776.422.220.286.100'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['D02.455.426.559.389.140.450.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Total port-access robot-assisted pulmonary lobectomy without utility thoracotomy. | Robot-assisted lobectomy has been reported elsewhere as a feasible technique for lobectomy. We report a modification of the previously reported technique using a complete port-access approach without utility thoracotomy. | ['Carcinoma, Non-Small-Cell Lung', 'Humans', 'Lung Neoplasms', 'Pneumonectomy', 'Robotics', 'Thoracic Surgery, Video-Assisted', 'Thoracotomy'] | 20,197,237 | [['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['E04.620', 'E04.928.600.600'], ['H01.671.293.643', 'J01.897.104.834', 'L01.224.050.375.630'], ['E01.370.388.250.840.830', 'E01.... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Effects of fluorocarbons with and without oxygen supplementation on cardiac hemodynamics and energetics. | Because of uncertainty about the mechanism by which fluorocarbons ameliorate myocardial ischemia, the effects of a fluorocarbon emulsion, perfluorodecalin and perfluorotripropylamine (Fluosol-DA 20% TM) with and without 100% O2 inhalation, on cardiac hemodynamics and energetics were studied in the anesthetized dog. Lef... | ['Animals', 'Blood Pressure', 'Dextrans', 'Dogs', 'Drug Combinations', 'Fluorocarbons', 'Heart', 'Heart Rate', 'Hemodynamics', 'Hydroxyethyl Starch Derivatives', 'Mass Spectrometry', 'Myocardium', 'Oxygen Consumption', 'Partial Pressure'] | 6,207,721 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D05.750.078.562.272', 'D09.698.365.272'], ['B01.050.150.900.649.313.750.250.216.200'], ['D26.310'], ['D02.455.526.510.435'], ['A07.541'], ['E01.370.600.875.500', 'G09.330.380.500'], ['G09.330.380'], ['D09.301.915.500', 'D09.698.365.855.500'], ['E05.196.566'], ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diagnosis of Wilson's disease in an asymptomatic sibling by DNA linkage analysis. | The molecular genetic diagnosis of Wilson's disease in the 5-year-old sister of a patient with Wilson's disease is reported. The girl was clinically free of disease and had no conventional biochemical markers of Wilson's disease (i.e., normal ceruloplasmin, normal copper in the serum, normal 24-hour urinary copper excr... | ['Adult', 'Biopsy', 'Child', 'Child, Preschool', 'Copper', 'DNA', 'Family Health', 'Female', 'Genetic Linkage', 'Hepatolenticular Degeneration', 'Humans', 'Liver', 'Male', 'Pedigree', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length'] | 7,498,669 | [['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D13.444.308'], ['N01.400.300'], ['G05.348'], ['C06.552.413',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Open-label lithium for the treatment of adolescents with bipolar depression. | OBJECTIVES: To investigate the effectiveness and tolerability of lithium for the treatment of acute depression in adolescents with bipolar disorder. We hypothesized that patients receiving open-label treatment with lithium during a 6-week period would experience a statistically and clinically significant decrease in de... | ['Adolescent', 'Antimanic Agents', 'Bipolar Disorder', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Lithium Carbonate', 'Male'] | 16,540,813 | [['M01.060.057'], ['D27.505.696.277.950.025', 'D27.505.954.427.210.950.025', 'D27.505.954.427.700.872.025'], ['F03.084.500'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.045.125.500', 'D01.200.275.150.550', 'D01.510.475']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Tumor Necrosis Factor Inhibitors and Cancer Recurrence in Swedish Patients With Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study. | Background: Use of tumor necrosis factor inhibitors (TNFi) in patients with a history of cancer remains a clinical dilemma.Objective: To investigate whether TNFi treatment in rheumatoid arthritis (RA) is associated with increased risk for cancer recurrence.Design: Population-based cohort study based on linkage of natio... | ['Aged', 'Algorithms', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Neoplasms', 'Neoplasms, Second Primary', 'Proportional Hazards Models', 'Recurrence', 'Risk Factors', 'Sweden', 'Tumor Necrosis Factor-alpha'] | 30,105,374 | [['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], [... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
The relationship between daily stress and urinary cortisol in a normal population: an emphasis on individual differences. | Twenty-three persons participated in a study examining the relationship between daily stressors and daily fluctuations in cortisol. For 21 days, the participants completed the Assessment of Daily Experience scale, which yielded frequency and intensity stress scores and gave an indication of the subjects' perceptions of... | ['Adolescent', 'Adult', 'Arousal', 'Female', 'Humans', 'Hydrocortisone', 'Individuality', 'Internal-External Control', 'Male', 'Middle Aged', 'Reference Values', 'Stress, Psychological', 'Workload'] | 8,292,837 | [['M01.060.057'], ['M01.060.116'], ['F02.830.104', 'G11.561.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['F01.752.488'], ['F01.829.379'], ['M01.060.116.630'], ['E05.978.810'], ['F01.145.126.990', 'F02.830.900'], ['I03.946... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Carbamazepine but not valproate induces CYP2A6 activity in smokers with mental illness. | BACKGROUND: Antiepileptic drugs (AED) are being increasingly used in the management of serious mental illness, but their effects on nicotine metabolism have not been studied.METHODS: This study investigated the effects of three AEDs (carbamazepine, oxcarbazepine, and valproic acid) on nicotine and nicotine metabolite l... | ['Adult', 'Anticonvulsants', 'Aryl Hydrocarbon Hydroxylases', 'Bipolar Disorder', 'Carbamazepine', 'Cotinine', 'Cytochrome P-450 CYP2A6', 'Enzyme Induction', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nicotine', 'Oxcarbazepine', 'Schizophrenia', 'Smoking', 'Valproic Acid', 'Young Adult'] | 20,719,908 | [['M01.060.116'], ['D27.505.954.427.080'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['F03.084.500'], ['D03.633.300.240.127'], ['D03.383.773.812.180'], ['D08.244.453.491.250', 'D08.811.682.690.708.170.450.250', 'D12.776.422.220.453.491.250'], ['G05.308.320.200'], ['B01.050.150.900.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Concomitant use of clopidogrel and proton pump inhibitors is not associated with major adverse cardiovascular events following coronary stent implantation. | BACKGROUND: Cytochrome P450 inhibition by proton pump inhibitors (PPIs) may attenuate the effectiveness of clopidogrel.AIM: To examine whether PPI use modifies the association between clopidogrel use and major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) with stent implantation, u... | ['Adult', 'Aged', 'Aged, 80 and over', 'Catheter Ablation', 'Clopidogrel', 'Cohort Studies', 'Cytochrome P-450 Enzyme Inhibitors', 'Cytochrome P-450 Enzyme System', 'Drug Interactions', 'Drug Therapy, Combination', 'Female', 'Gastroesophageal Reflux', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Platelet ... | 22,050,009 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.808.750.500', 'E04.014.760.500'], ['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D27.505.389.500', 'D27.50... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effectiveness of propranolol for cocaine dependence treatment may depend on cocaine withdrawal symptom severity. | Propranolol may reduce symptoms of autonomic arousal associated with early cocaine abstinence and improve treatment outcome. This trial was an 8-week, double-blind, placebo-controlled trial of propranolol in 108 cocaine dependent subjects. The primary outcome measure was quantitative urinary benzoylecgonine levels. Sec... | ['Adolescent', 'Adult', 'Anti-Anxiety Agents', 'Cocaine', 'Cocaine-Related Disorders', 'Double-Blind Method', 'Humans', 'Middle Aged', 'Propranolol', 'Psychiatric Status Rating Scales', 'Severity of Illness Index', 'Substance Withdrawal Syndrome'] | 11,297,832 | [['M01.060.057'], ['M01.060.116'], ['D27.505.696.277.950.015', 'D27.505.954.427.210.950.015', 'D27.505.954.427.700.872.015'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['C25.775.300', 'F03.900.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hind-limb motor ability in Lewis rats during the onset and recovery phases of experimental autoimmune encephalomyelitis. | Hind-limb motor function in adult female Lewis rats with experimental autoimmune encephalomyelitis (EAE) was investigated using an objective behavioral measurement of motor ability. Rats were pretrained to avoid falling from the external surface of a power-driven running wheel. The performance of EAE-group rats on the ... | ['Animals', 'Disease Models, Animal', 'Encephalomyelitis, Autoimmune, Experimental', 'Female', 'Guinea Pigs', 'Hindlimb', 'Motor Activity', 'Myelin Basic Protein', 'Rats', 'Rats, Inbred Lew'] | 6,167,315 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625.300', 'E05.598.500.500.500'], ['B01.050.150.900.649.313.992.550'], ['A13.473'], ['F01.145.632', 'G11.427.410.698'], ['D12.776.543.620.540', 'D12.776.631.580.510'], ['B01.050.15... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin. | N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy. | ['Animals', 'Anti-Bacterial Agents', 'Daptomycin', 'Mice', 'Microbial Sensitivity Tests', 'Ornithine', 'Sepsis', 'Staphylococcal Infections', 'Staphylococcus aureus'] | 14,622,998 | [['B01.050'], ['D27.505.954.122.085'], ['D04.345.566.270', 'D10.477.500', 'D12.644.365.500', 'D12.644.641.270'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['D12.125.068.665', 'D12.125.095.765'], ['C01.757', 'C23.550.470.790.500'], ['C01.150.252.410.868']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination and pharmacology of a new hydroxylated metabolite of tamoxifen observed in patient sera during therapy for advanced breast cancer. | A new hydroxylated metabolite of tamoxifen, Metabolite Y [trans-1-(p-beta-hydroxyethoxyphenyl)-1,2-diphenylbut-1-ene] was characterized and subsequently measured by high-performance liquid chromatography in serum from patients receiving normal (10 mg twice daily) and high dose (greater than or equal to 150 mg twice dai... | ['Animals', 'Biological Assay', 'Breast Neoplasms', 'Chromatography, High Pressure Liquid', 'Estradiol', 'Female', 'Humans', 'Rats', 'Tamoxifen', 'Uterus'] | 6,825,112 | [['B01.050'], ['E05.091'], ['C04.588.180', 'C17.800.090.500'], ['E05.196.181.400.300'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.700'], ['D02.455.426.559.389.150.700.900'], ['A05.360.319.679']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Matrix metalloproteinases -2 and -9 and their endogenous tissue inhibitors in fetal membrane repair following fetoscopy in a rabbit model. | The cellular mechanisms underlying fetal membrane repair are poorly understood. Matrix metalloproteinases (MMP) and the endogenous tissue inhibitors of metalloproteinases (TIMP) play a key role in the control of turnover of extracellular matrix in fetal membranes at normal parturition and preterm prelabour rupture of t... | ['Animals', 'Extraembryonic Membranes', 'Female', 'Fetoscopy', 'Gestational Age', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 9', 'Pregnancy', 'Rabbits', 'Tissue Inhibitor of Metalloproteinase-1', 'Tissue Inhibitor of Metalloproteinase-2', 'Tissue Inhibitor of Metalloproteinase-3', 'Tissue Inhibitor of Meta... | 10,775,654 | [['B01.050'], ['A10.615.284', 'A16.254.750'], ['E01.370.378.630.300', 'E01.370.388.250.280', 'E02.467.750', 'E04.502.250.280', 'E04.520.280'], ['G07.345.500.325.235.968', 'G08.686.320'], ['D08.811.277.656.300.480.205.352', 'D08.811.277.656.300.480.252.420', 'D08.811.277.656.300.480.525.700.150', 'D08.811.277.656.675.37... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determinants of sentence comprehension in aphasic patients in sentence-picture matching tasks. | The results of two studies of sentence comprehension in aphasic patients using sentence-picture matching tests are presented. In the first study, 52 aphasic patients were tested on 10 sentence types. Analysis of the number of correct responses per sentence type showed effects of syntactic complexity and number of propo... | ['Adult', 'Aged', 'Aphasia', 'Female', 'Humans', 'Language Tests', 'Male', 'Memory', 'Middle Aged', 'Semantics', 'Speech Perception', 'Visual Perception'] | 9,210,113 | [['M01.060.116'], ['M01.060.116.100'], ['C10.597.606.150.500.800.100', 'C23.888.592.604.150.500.800.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.240'], ['F02.463.425.540'], ['M01.060.116.630'], ['L01.559.598.745'], ['F02.463.593.071.875', 'G07.888.125.875'], ['F02.463.593.932']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Modular modeling of cellular systems with ProMoT/Diva. | MOTIVATION: Need for software to setup and analyze complex mathematical models for cellular systems in a modular way, that also integrates the experimental environment of the cells.RESULTS: A computer framework is described which allows the building of modularly structured models using an abstract, modular and general ... | ['Algorithms', 'Cell Physiological Phenomena', 'Computer Simulation', 'Databases, Factual', 'Metabolism', 'Models, Biological', 'Software', 'Software Design', 'User-Computer Interface'] | 12,801,880 | [['G17.035', 'L01.224.050'], ['G04'], ['L01.224.160'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['G03'], ['E05.599.395'], ['L01.224.900'], ['L01.224.900.820'], ['L01.224.900.910']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The use of archived tags in retrospective genetic analysis of fish. | Collections of historical tissue samples from fish (e.g. scales and otoliths) stored in museums and fisheries institutions are precious sources of DNA for conducting retrospective genetic analysis. However, in some cases, only external tags used for documentation of spatial dynamics of fish populations have been preser... | ['Animals', 'DNA', 'Gadus morhua', 'Marine Biology', 'Museums', 'Otolithic Membrane'] | 24,299,474 | [['B01.050'], ['D13.444.308'], ['B01.050.150.900.493.467.400'], ['H01.158.273.248.750.500', 'H01.277.249.750.500', 'H01.277.750.500'], ['J03.570', 'K01.400.152.552'], ['A09.246.300.909.625.125.680']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Humanities [K]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Determining the site of airway obstruction in obstructive sleep apnea with airway pressure measurements during sleep]. | OBJECTIVE: Determine the site(s) of upper airway obstruction and the influence of sleep stage on the pattern of obstruction with upper airway (UA) pressure measurement. Analyses the clinical value of UA pressure measurement and it's influenced factors.METHODS: 30 OSAS patients underwent UA pressure measurement during p... | ['Adult', 'Airway Obstruction', 'Airway Resistance', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pressoreceptors', 'Sleep', 'Sleep Apnea, Obstructive'] | 12,762,003 | [['M01.060.116'], ['C08.618.846.185'], ['E01.370.386.700.050', 'G09.772.060'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A08.675.650.915.750.750', 'A08.800.050.800.900.700', 'A08.800.950.750.750', 'A11.671.650.915.750.750'], ['F02.830.855', 'G11.561.803'], ['C08.618.085.852.850', 'C10.886.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
L-deprenyl (selegiline) limits the repetitive firing of action potentials in rat hippocampal CA1 neurons via a dopaminergic mechanism. | The effects of L-deprenyl (selegiline), a highly selective monoamine oxidase type B (MAO-B) inhibitor, on cell excitability of rat hippocampal CA1 neurons were examined in slice preparations using intracellular recording techniques. Superfusion of L-deprenyl (10 and 20 microM) reversibly limited the repetitive firing (... | ['Action Potentials', 'Analysis of Variance', 'Animals', 'Antiparkinson Agents', 'Dopamine', 'In Vitro Techniques', 'Male', 'Membrane Potentials', 'Monoamine Oxidase Inhibitors', 'Pargyline', 'Pyramidal Cells', 'Pyridines', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Dopamine D1', 'Selegiline'] | 9,125,428 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D27.505.954.427.090.050'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E05.481'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], [... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rationale and design of the Randomized Evaluation of patients with Stable angina Comparing Utilization of noninvasive Examinations (RESCUE) trial. | RESCUE is a phase III, randomized, controlled, multicenter, comparative efficacy study, designed to compare two diagnostic imaging/treatment paradigms that use coronary computed tomography angiography (CCTA) or single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) for assisting in the diag... | ['Adrenergic beta-Antagonists', 'Adult', 'Aged', 'Aged, 80 and over', 'Angina, Stable', 'Angiotensin Receptor Antagonists', 'Angiotensin-Converting Enzyme Inhibitors', 'Antihypertensive Agents', 'Computed Tomography Angiography', 'Coronary Angiography', 'Diet Therapy', 'Exercise', 'Female', 'Heart Diseases', 'Humans', ... | 27,595,676 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.647.187.362', 'C14.907.585.187.362', 'C23.888.592.612.233.500.575'], ['D27.505.519.162'], ['D27.505.519.389.745.085'], ['D27.505.954.411.162'], ['E01.370.350.350.810.335', 'E01.370.3... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Ultrastructural aspects of peptidergic modulation in the peripheral nervous system of Helix pomatia. | The ultrastructural characteristics of peptidergic peripheral contacts in the snail, Helix pomatia, were investigated, with special attention to the innervation of the heart, buccal mass, and salivary gland by Mytilus inhibitory peptide-immunoreactive neurons. Following the application of correlative light- and electro... | ['Animals', 'FMRFamide', 'Heart', 'Helix, Snails', 'Immunohistochemistry', 'Microscopy, Electron', 'Mouth Mucosa', 'Nervous System', 'Oligopeptides', 'Salivary Glands'] | 10,862,110 | [['B01.050'], ['D12.644.400.235', 'D12.776.631.650.235'], ['A07.541'], ['B01.050.500.644.400.750.450'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effectiveness and safety of dabigatran therapy in daily-care patients with atrial fibrillation. Results from the Dresden NOAC Registry. | The effectiveness and safety of dabigatran for stroke prevention in atrial fibrillation (SPAF) demonstrated in RE-LY needs to be confirmed in daily care. To evaluate treatment persistence, effectiveness and safety of dabigatran therapy in SPAF patients in daily care, we used data from an ongoing, prospective, non-inter... | ['Administration, Oral', 'Aged', 'Aged, 80 and over', 'Antithrombins', 'Atrial Fibrillation', 'Dabigatran', 'Drug Administration Schedule', 'Embolism', 'Female', 'Germany', 'Hemorrhage', 'Humans', 'Intention to Treat Analysis', 'Ischemic Attack, Transient', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Prospective S... | 25,739,533 | [['E02.319.267.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.519.389.745.800.449', 'D27.505.954.502.119.500'], ['C14.280.067.198', 'C23.550.073.198'], ['D03.383.725.192', 'D03.633.100.103.280'], ['E02.319.283'], ['C14.907.355.350'], ['Z01.542.315'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.11... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Oncofetal proteins - their character and clinical significance as tumour-markers (author's transl)]. | Substances with tumour-marker functions were characterized in the present review. Based on detailed knowledge available for the oncofetal proteins AFP and CEA conclusions were drawn in respect to the present position and future development for this group of substances. | ['Antigens, Neoplasm', 'Carcinoembryonic Antigen', 'Diagnosis, Differential', 'Humans', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Neoplasms', 'Prognosis', 'alpha-Fetoproteins'] | 6,163,265 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Value of adjuvant chemotherapy in patients with resected stage IB solid predominant and solid non-predominant lung adenocarcinoma. | BACKGROUND: The use of adjuvant chemotherapy (ACT) for stage IB lung adenocarcinoma remains controversial. We examined the benefits of ACT in stage IB patients with tumors composed of solid material.METHODS: The records of 309 patients with stage IB lung adenocarcinoma who had undergone complete resection between 2006 ... | ['Adenocarcinoma of Lung', 'Antineoplastic Combined Chemotherapy Protocols', 'Carboplatin', 'Chemotherapy, Adjuvant', 'Cisplatin', 'Deoxycytidine', 'Docetaxel', 'Female', 'Follow-Up Studies', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Paclitaxel', 'Pemetrexed', 'Ret... | 30,561,142 | [['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.257.125'], ['E02.186.170', 'E02.319.170'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['D02.455.426.392.368.242.888.389', '... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Interactions of gephyrotoxin with the acetylcholine receptor-ionic channel complex. II. Enhancement of desensitization. | The actions of the tricyclic alkaloid gephyrotoxin ( GyTX ) on the extrajunctional and junctional acetylcholine (ACh) sensitivity and desensitization were studied in the chronically denervated rat soleus muscle and cutaneous pectoris muscle of the frog. At low concentrations, GyTX greatly depressed the extrajunctional ... | ['Acetylcholine', 'Alkaloids', 'Amphibian Venoms', 'Animals', 'Carbachol', 'Drug Synergism', 'Electric Organ', 'Evoked Potentials', 'Ion Channels', 'Kinetics', 'Motor Endplate', 'Muscle Denervation', 'Muscles', 'Ranidae', 'Rats', 'Receptors, Nicotinic', 'Torpedo'] | 6,328,265 | [['D02.092.211.111'], ['D03.132'], ['D20.888.033', 'D23.946.833.033'], ['B01.050'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['G07.690.773.968.477'], ['A13.332'], ['G07.265.216.500', 'G11.561.200.500'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['G01.374.661', 'G02.111.490'], ['A... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondrial injury and cognitive function in HIV infection and methamphetamine use. | OBJECTIVE: In this work, we evaluated the association of human immunodeficiency virus (HIV) infection and methamphetamine (METH) use with mitochondrial injury in the brain and its implication on neurocognitive impairment.DESIGN: Mitochondria carry their genome (mtDNA) and play a critical role in cellular processes in t... | ['Adult', 'Brain', 'Central Nervous System Stimulants', 'Cognition', 'Cohort Studies', 'DNA, Mitochondrial', 'HIV Infections', 'Humans', 'Male', 'Methamphetamine', 'Middle Aged', 'Mitochondria', 'Neurocognitive Disorders', 'Polymerase Chain Reaction', 'Substance-Related Disorders'] | 26,807,965 | [['M01.060.116'], ['A08.186.211'], ['D27.505.696.282', 'D27.505.954.427.220'], ['F02.463.188'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D13.444.308.283.225'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase. | Bacterial YidC, an evolutionally conserved membrane protein, functions as a membrane protein chaperone in cooperation with the Sec translocon and as an independent insertase for membrane proteins. In Gram-negative bacteria, the transmembrane and periplasmic regions of YidC interact with the Sec proteins, forming a mult... | ['Bacillus', 'Crystallography, X-Ray', 'Escherichia coli', 'Escherichia coli Proteins', 'Membrane Proteins', 'Membrane Transport Proteins', 'Molecular Chaperones', 'Protein Structure, Secondary'] | 25,466,392 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['E05.196.309.742.225'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D12.776.543'], ['D12.776.157.530', 'D12.776.543.585'], ['D12.776.580'], ['G02.111.570.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neonatal deafferentation prevents normal expression of synaptic vesicle antigens in the developing rat superior cervical ganglion. | The effect of neonatal deafferentation of the rat superior cervical ganglion (SCG) on the expression of two synaptic vesicle proteins was studied to assess the role of transsynaptic influences in the regulation of these neural antigens in the SCG. The two proteins studied were a 65 kilodalton integral membrane protein ... | ['Animals', 'Animals, Newborn', 'Antibodies, Monoclonal', 'Brain', 'Decerebrate State', 'Female', 'Ganglia, Sympathetic', 'Gene Expression Regulation', 'Male', 'Membrane Proteins', 'Molecular Weight', 'Nerve Tissue Proteins', 'Rats', 'Rats, Inbred Strains', 'Synapsins', 'Synaptic Vesicles'] | 3,138,771 | [['B01.050'], ['B01.050.050.282'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A08.186.211'], ['C10.597.305', 'C23.888.592.298'], ['A08.340.315.350', 'A08.800.050.300.300', 'A08.800.050.800.300'], ['G05.308'], ['D12.776.543'], ['G02.494'], ['D12.776.631'], ['B01.050.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs. | Caffeine inhibits the G2 checkpoint activated by DNA damage and enhances the toxicity of DNA-damaging agents towards p53-defective cancer cells. The relationship between structure and G2 checkpoint inhibition was determined for 56 caffeine analogs. Replacement of the methyl group at position 3 or 7 resulted in loss of ... | ['Breast Neoplasms', 'Caffeine', 'Cobalt Radioisotopes', 'DNA Damage', 'DNA Repair', 'G2 Phase', 'Humans', 'Structure-Activity Relationship', 'Tumor Cells, Cultured', 'Tumor Suppressor Protein p53'] | 10,762,633 | [['C04.588.180', 'C17.800.090.500'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D01.268.556.185.500.354', 'D01.268.956.155.500.354', 'D01.496.239.354', 'D01.496.749.256', 'D01.552.544.185.500.354'], ['G05.200'], ['G02.111.222', 'G05.219'], ['G04.144.500.340'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[High resolution ultrasound examination in the diagnosis of the undescended testis in the inguinal region]. | Twenty-six undescended testes in 22 patients between 1 and 31 years old were evaluated with ultrasonographic examination between October, 1981 and December, 1985. All 22 patients were operated on, and the accuracy of the ultrasonic diagnosis was evaluated in comparison to that of palpation diagnosis. Fourteen of 26 tes... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Cryptorchidism', 'Humans', 'Infant', 'Inguinal Canal', 'Male', 'Palpation', 'Ultrasonography'] | 2,897,766 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C12.294.829.258', 'C12.706.258', 'C16.131.939.258', 'C19.391.829.258'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['A01.923.047.412'], ['E01.370.600.600'], ['E01.370.350.850']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Impact of blood testing on patient disposition from the emergency department. | OBJECTIVE: To determine whether blood test results lead to a change in planned disposition of patients from the ED.METHODS: A prospective review of the anticipated and actual disposition of patients from the ED before and after blood test results, including stratification by seniority of medical staff.RESULTS: There we... | ['Analysis of Variance', 'Attitude of Health Personnel', 'Diagnostic Tests, Routine', 'Emergency Service, Hospital', 'Emergency Treatment', 'Health Services Research', 'Humans', 'Medical Staff, Hospital', 'Patient Admission', 'Patient Discharge', 'Predictive Value of Tests', 'Prospective Studies', 'Surveys and Question... | 12,675,621 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.100.050', 'N05.300.100'], ['E01.370.395'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E02.365'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Expression levels of survivin, Bcl-2, and KAI1 proteins in cervical cancer and their correlation with metastasis. | Cervical cancer is associated with abnormal expression of multiple genes. Survivin and Bcl-2 proteins are apoptosis inhibitors. The tumor suppressor gene CD82, which encodes the protein KAI1, is downregulated in cervical cancer, and is associated with differentiation degree. We investigated the expression levels of thr... | ['Adult', 'Disease Progression', 'Female', 'Gene Expression', 'Humans', 'Immunohistochemistry', 'Inhibitor of Apoptosis Proteins', 'Kangai-1 Protein', 'Middle Aged', 'Neoplasm Grading', 'Neoplasm Metastasis', 'Neoplasm Staging', 'Prognosis', 'Proto-Oncogene Proteins c-bcl-2', 'Survivin', 'Uterine Cervical Neoplasms', '... | 26,681,053 | [['M01.060.116'], ['C23.550.291.656'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.18... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Lesson of the month: Rowing-induced laryngeal obstruction: a novel cause of exertional dyspnoea: characterised by direct laryngoscopy. | Exercise-induced laryngeal obstruction (EILO) is a key differential diagnosis for unexplained dyspnoea in athletes. The gold standard means for diagnosis of EILO is direct laryngoscopy, performed continuously, while an athlete undertakes the specific sport that precipitates their symptoms. This report provides the firs... | ['Airway Obstruction', 'Diagnosis, Differential', 'Dyspnea', 'Exercise Test', 'Female', 'Humans', 'Laryngeal Diseases', 'Laryngoscopy', 'Physical Exertion', 'Young Adult'] | 25,260,575 | [['C08.618.846.185'], ['E01.171'], ['C08.618.326', 'C23.888.852.371'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.360', 'C09.400'], ['E01.370.386.460', 'E01.370.388.250.525', 'E04.502.250.525', 'E04.580.373'], ['G11.427.683'], ['M01.060.116.815'... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Changes in Home Parenteral Nutrition Practice Based on the Canadian Home Parenteral Nutrition Patient Registry. | BACKGROUND: Since 2005, the Canadian home parenteral nutrition (HPN) registry has collected data on patients' demography, outcomes, and HPN clinical practice. At annual meetings, Canadian HPN programs review and discuss results.AIM: To evaluate changes over time in patient demography, outcomes, and HPN clinical practic... | ['Adult', 'Canada', 'Catheter-Related Infections', 'Catheterization, Peripheral', 'Central Venous Catheters', 'Female', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Nutrition Assessment', 'Parenteral Nutrition, Home', 'Registries', 'Retrospective Studies', 'Sepsis', 'Short Bowel Syndrome'] | 26,407,599 | [['M01.060.116'], ['Z01.107.567.176'], ['C01.195'], ['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['E07.132.750.500'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.585', 'N05.715.360.300.560', 'N06.850.505.557', 'N06.... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cytotoxicity investigation of a new hydroxyapatite scaffold with improved structural design. | Introduction: Biodegradable porous scaffolds are found to be very promising bone substitutes, acting
as a temporary physical support to guide new tissue regeneration, until the entire scaffold is totally
degraded and replaced by the new tissue.Objective: The aim of this study was to investigate cytotoxicity of a synthe... | ['Animals', 'Biocompatible Materials', 'Bone Substitutes', 'Cell Line', 'Durapatite', 'Fibroblasts', 'Mice', 'Microscopy, Electron, Scanning', 'Porosity', 'Tissue Scaffolds'] | 29,648,745 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D25.130.325', 'J01.637.051.130.325'], ['A11.251.210'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['A11.329.228'], ['B01.050.150.900.649.313.992.635.505.500'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Growth failure in vitamin D-deficient rat pups. | Vitamin D-deficient rat pups were produced by feeding normal impregnated rats a diet deficient in vitamin D after mating. The rat pups appeared normal at birth but stopped growing at 1 week of age. Despite this growth failure, these pups were normocalcemic. Analyses of calvaria from a similar group of dams given vitami... | ['Animals', 'Calcium', 'Cholecalciferol', 'Female', 'Growth Disorders', 'Lactation', 'Maternal-Fetal Exchange', 'Pregnancy', 'Rats', 'Vitamin D Deficiency'] | 6,268,261 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D04.210.500.247.222.159', 'D04.210.500.247.808.146', 'D04.210.500.812.768.196', 'D10.570.938.146'], ['C23.550.393'], ['G08.686.523', 'G08.686.702.500'], ['G08.686.784.769.455'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700'], ['C18... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of neural stem cell surface marker CD133 in balloon cells of human focal cortical dysplasia. | PURPOSE: Focal cortical dysplasia (CD) is characterized by the presence of dysmorphic neurons, laminar and columnar disorganization. A few patients with CD have balloon cells intermixed with dysmorphic neurons. The cellular characteristics of balloon cells remain unknown. This study was intended to determine further th... | ['AC133 Antigen', 'Antigens, CD', 'Biomarkers', 'Cell Differentiation', 'Cerebral Cortex', 'Child', 'Child, Preschool', 'Female', 'Genes, bcl-2', 'Glycoproteins', 'Humans', 'Immunohistochemistry', 'Infant', 'Intermediate Filament Proteins', 'Male', 'Microscopy, Confocal', 'Nerve Tissue Proteins', 'Nervous System Malfor... | 16,302,851 | [['D12.776.395.550.007', 'D12.776.543.550.023'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.101'], ['G04.152'], ['A08.186.211.200.885.287.500'], ['M01.060.406'], ['M01.060.406.448'], ['G05.360.340.024.340.375.500.791.150'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.37... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Mechanisms regulating the copy numbers of six LTR retrotransposons in the genome of Drosophila melanogaster. | There has been debate over the mechanisms that control the copy number of transposable elements in the genome of Drosophila melanogaster. Target sites in D. melanogaster populations are occupied at low frequencies, suggesting that there is some form of selection acting against transposable elements. Three main theories... | ['Animals', 'Drosophila melanogaster', 'Gene Dosage', 'Genome', 'Retroelements', 'Selection, Genetic', 'Terminal Repeat Sequences', 'X Chromosome'] | 12,068,968 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G05.380.350'], ['G05.360.340'], ['D13.444.308.760', 'G02.111.570.080.708.330.800', 'G05.360.080.708.330.800', 'G05.360.340.024.425.800'], ['G05.783'], ['G02.111.570.080.708.850', 'G05.360.080.708.850'], ['A11.284.187.865.982', 'G05.360.162.865.982']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association of adolescent obesity with risk of severe obesity in adulthood. | CONTEXT: Although the prevalence of obesity has increased in recent years, individuals who are obese early in life have not been studied over time to determine whether they develop severe obesity in adulthood, thus limiting effective interventions to reduce severe obesity incidence and its potentially life-threatening ... | ['Adolescent', 'Adult', 'Age of Onset', 'Body Weight', 'Child', 'Cohort Studies', 'Continental Population Groups', 'Female', 'Humans', 'Incidence', 'Male', 'Obesity', 'Risk', 'Severity of Illness Index', 'Sex Factors', 'United States', 'Young Adult'] | 21,063,014 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['M01.686.508'], ['B01.0... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
New records of the Japanese seahorse Hippocampus mohnikei in Southeast Asia lead to updates in range, habitat and threats. | New records of the Japanese seahorse Hippocampus mohnikei from Cambodia, Malaysia, Thailand and Vietnam, along with recently published studies from India and Singapore, have greatly expanded the known range of H. mohnikei within Southeast Asia. These new records reveal novel habitat preferences and threats to H. mohnik... | ['Animals', 'Asia, Southeastern', 'Cambodia', 'Conservation of Natural Resources', 'Ecosystem', 'Endangered Species', 'Malaysia', 'Smegmamorpha', 'Thailand', 'Vietnam'] | 26,840,386 | [['B01.050'], ['Z01.252.145'], ['Z01.252.145.182'], ['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['B01.050.050.565', 'G16.500.275.157.049.250', 'N06.230.080.200', 'N06.230.124.049.250'], ['Z01.252.145.487'], ['B01.050.150.900.493.850'], ['Z01.252.145.841'], ['Z01.252.145.945']] | ['Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Hepatic and muscle injuries in mice treated with heptachlor. | Heptachlor is a major component of the insecticide, chlordane. It is a health hazard but is still in use in some countries of Southeast Asia. To elucidate the toxicity of heptachlor its effects on mice after oral and intraperitoneal administration were studied. A 3-day group, 92-day group and 180-day group were given h... | ['Alanine Transaminase', 'Animals', 'Blood Glucose', 'Body Weight', 'Creatine Kinase', 'Heptachlor', 'Lipid Peroxides', 'Liver', 'Male', 'Mice', 'Muscle, Smooth', 'Organ Size'] | 2,244,340 | [['D08.811.913.477.700.100'], ['B01.050'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D08.811.913.696.640.150'], ['D02.455.526.439.516'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Malignant idiopathic anaphylaxis: three additional cases and extended evaluation. | Northwestern University's Division of Allergy and Immunology (NUAI) has evaluated and treated 225 patients with idiopathic anaphylaxis (IA) over a period of 16 years. Four patients have been identified with malignant IA. The term "malignant" is used to identify those patients with the most severe form of IA that is res... | ['Adrenal Cortex Hormones', 'Adult', 'Aged', 'Anaphylaxis', 'Drug Therapy, Combination', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Ketotifen', 'Male', 'Prednisone', 'Substance-Related Disorders'] | 1,626,758 | [['D06.472.040'], ['M01.060.116'], ['M01.060.116.100'], ['C20.543.480.099'], ['E02.319.310'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.886.778.370', 'D03.383.621.370', 'D03.383.903.370'], ['D04.210.500.745.432.719.702'], ['C25.775', 'F03.900']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Androgen regulation of poly(A) polymerase in the ventral prostate of rat. | The effect of various hormones on the levels of poly(A) polymerase in the ventral prostate of castrated rats was investigated. It was observed that this enzyme is specifically induced by androgens; progesterone and estradiol-17 beta did not cause stimulation of poly(A) polymerase activity. Dihydrotestosterone-induced p... | ['Androgens', 'Animals', 'Castration', 'Dihydrotestosterone', 'Enzyme Induction', 'Estradiol', 'Male', 'Nucleotidyltransferases', 'Polynucleotide Adenylyltransferase', 'Progesterone', 'Prostate', 'Rats', 'Rats, Inbred Strains', 'Testosterone'] | 6,098,056 | [['D27.505.696.399.472.161'], ['B01.050'], ['E04.270.282', 'E04.950.165'], ['D04.210.500.054.040.248', 'D06.472.334.851.968.964'], ['G05.308.320.200'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D08.811.913.696.445'], ['D08.811.913.696.445.650'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical characteristics of Japanese patients with severe hypertriglyceridemia. | BACKGROUND: Although of interest, few data exist on the clinical characteristics of Japanese patients with an extremely high triglyceride level (? 1000 mg/dL).OBJECTIVE: We assessed the clinical characteristics of Japanese patients with an extremely high triglyceride level.METHODS: We investigated the presence of coron... | ['Adult', 'Coronary Artery Disease', 'Female', 'Humans', 'Hypertriglyceridemia', 'Japan', 'Male', 'Middle Aged', 'Pancreatitis', 'Pregnancy', 'Triglycerides'] | 26,228,669 | [['M01.060.116'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.584.500.500.851'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['C06.689.750'], ['G08.686.784.769'], ['D10.351.801']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Enzyme immunoassay for pancreatic lipase: comparison with turbidimetric method in pancreatic diseases. | We report the results of the analytical and clinical evaluation of a specific enzyme immunoassay for determination of human pancreatic lipase, in comparison with a turbidimetric method, in pancreatic pathology. Under standardized conditions of incubation time and temperature we found intraassay coefficient of variation... | ['Acute Disease', 'Adult', 'Aged', 'Child, Preschool', 'Chronic Disease', 'Clinical Enzyme Tests', 'Cystic Fibrosis', 'Humans', 'Immunoenzyme Techniques', 'Infant', 'Lipase', 'Male', 'Middle Aged', 'Nephelometry and Turbidimetry', 'Pancreas', 'Pancreatic Diseases', 'Pancreatic Neoplasms', 'Pancreatitis', 'Reference Val... | 3,899,406 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406.448'], ['C23.550.291.500'], ['E01.370.225.124.200', 'E05.196.427.200', 'E05.200.124.200'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation. | The heterotrimeric Sec61p complex is a major component of the protein-conducting channel of the endoplasmic reticulum (ER) membrane, associating with either ribosomes or the Sec62/63 complex to perform co- and posttranslational transport, respectively. We show by electron microscopy that purified mammalian and yeast Se... | ['Animals', 'Biological Transport', 'Cell Compartmentation', 'Detergents', 'Dogs', 'Endoplasmic Reticulum', 'Freeze Fracturing', 'Fungal Proteins', 'Heat-Shock Proteins', 'Image Enhancement', 'Ion Channel Gating', 'Ion Channels', 'Macromolecular Substances', 'Membrane Proteins', 'Membrane Transport Proteins', 'Models, ... | 8,929,540 | [['B01.050'], ['G03.143'], ['G04.128'], ['D27.720.877.265', 'J01.516.381'], ['B01.050.150.900.649.313.750.250.216.200'], ['A11.284.430.214.190.875.248'], ['E01.370.225.500.620.620.260', 'E01.370.225.750.600.620.260', 'E05.200.500.620.620.260', 'E05.200.750.600.620.260'], ['D12.776.354'], ['D12.776.580.216'], ['E01.370.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Clinical efficacy of sertraline alone and augmented with gabapentin in recently abstinent cocaine-dependent patients with depressive symptoms. | BACKGROUND: Cocaine dependence is a major public health problem with no available robustly effective pharmacotherapy. This study's aim was to determine if treatment with sertraline (SERT) or SERT plus gabapentin (GBP) improved treatment retention, depressive symptoms, and/or cocaine use.METHODS: Depressed cocaine-depen... | ['Adult', 'Amines', 'Cocaine-Related Disorders', 'Cognitive Behavioral Therapy', 'Combined Modality Therapy', 'Cyclohexanecarboxylic Acids', 'Depression', 'Diagnosis, Dual (Psychiatry)', 'Double-Blind Method', 'Drug Therapy, Combination', 'Female', 'GABA Agonists', 'Gabapentin', 'Humans', 'Male', 'Medication Adherence'... | 24,525,654 | [['M01.060.116'], ['D02.092'], ['C25.775.300', 'F03.900.300'], ['F04.754.137.350'], ['E02.186'], ['D02.241.223.268', 'D02.455.426.392.368.367.218'], ['F01.145.126.350'], ['E01.190'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.310'], ['D27.505.519.625.240.200', 'D27.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Electrochemical oxidation of 1H,1H,2H,2H-perfluorooctane sulfonic acid (6:2 FTS) on DSA electrode: operating parameters and mechanism. | The 6:2 FTS was the substitute for perfluorooctane sulfonate (PFOS) in the chrome plating industry in Japan. Electrochemical oxidation of 6:2 FTS was investigated in this study. The degradabilities of PFOS and 6:2 FTS were tested on the Ti/SnO₂-Sb₂O₅-Bi₂O₃ anode. The effects of current density, potential, and supportin... | ['Alkanesulfonic Acids', 'Carbohydrates', 'Electrochemical Techniques', 'Fluorocarbons', 'Oxidation-Reduction', 'Phycobilins', 'Proteins', 'Spectrometry, Fluorescence', 'Water Pollutants, Chemical'] | 25,108,730 | [['D02.455.326.146.100', 'D02.886.645.600.055'], ['D09'], ['E05.301'], ['D02.455.526.510.435'], ['G02.700', 'G03.295.531'], ['D03.383.129.578.840.468', 'D03.633.400.909.468', 'D04.345.783.468'], ['D12.776'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['D27.888.284.903.655']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dissecting the roles of tyrosines 490 and 785 of TrkA protein in the induction of downstream protein phosphorylation using chimeric receptors. | Receptor tyrosine kinases generally act by forming phosphotyrosine-docking sites on their own endodomains that propagate signals through cascades of post-translational modifications driven by the binding of adaptor/effector proteins. The pathways that are stimulated in any given receptor tyrosine kinase are a function ... | ['Animals', 'Humans', 'PC12 Cells', 'Phosphorylation', 'Platelet-Derived Growth Factor', 'Rats', 'Receptor, trkA', 'Receptors, Platelet-Derived Growth Factor', 'Recombinant Fusion Proteins', 'Signal Transduction', 'Tyrosine'] | 23,589,303 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.750', 'A11.251.860.180.750', 'A11.299.500'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D12.644.276.910', 'D12.776.124.625', 'D12.776.467.910', 'D23.529.910'], ['B01.050.150.900.649.313.992.635.505.700'], ['D08.811.913.696.620.682.725.40... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of occlusive and semiocclusive dressings on the return of barrier function to transepidermal water loss in standardized human wounds. | Clinical observation and histologic examination of excised wounds have confirmed that occlusive dressings promote rapid wound reepithelialization. However, normalization of barrier function has not been routinely assessed in studies of occlusive dressing effects on wound healing. We examined the effects of occlusive dr... | ['Adult', 'Body Water', 'Humans', 'Occlusive Dressings', 'Skin Absorption', 'Wound Healing'] | 2,715,429 | [['M01.060.116'], ['A12.207.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.101.650'], ['G03.015.500.750', 'G03.787.024.500.750', 'G07.690.725.015.500.750', 'G13.750.778'], ['G16.762.891']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dysequilibrium/ataxic diplegia with immunodeficiency. | A girl with purine nucleoside phosphorylase (PNP) deficiency is described. The nature of the motor disorder is similar to other children since found to have PNP deficiency. It is suggested that the diagnosis be considered in any child with unexplained dysequilibrium/ataxic diplegia. Other previously unreported features... | ['Female', 'Humans', 'Infant', 'Lymphoma, Non-Hodgkin', 'Lymphopenia', 'Neutropenia', 'Psychomotor Disorders', 'Purine-Nucleoside Phosphorylase'] | 1,929,496 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683.515.761.480'], ['C15.378.553.546.605', 'C20.673.627'], ['C15.378.553.546.184.564'], ['C10.597.606.881', 'C23.888.592.604.882', 'F01.700.875'], ['D08.811.913.400.725.800']] | ['Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regulation of CD11b/CD18 expression in human neutrophils by phospholipase A2. | Recent evidence suggests that phospholipase A2 (PLA2)-derived lipid mediators may regulate a number of neutrophil responses including degranulation and adhesion. In view of the potential role of PLA2 in stimulus-secretion coupling, we examined the relationship between PLA2 activation and the surface expression of CD11b... | ['Arachidonic Acid', 'Cell Adhesion', 'Cell Degranulation', 'Enzyme Activation', 'Homosteroids', 'Humans', 'Macrophage-1 Antigen', 'Neutrophils', 'Phospholipases A', 'Phospholipases A2', 'Sesterterpenes', 'Terpenes'] | 8,228,253 | [['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['G04.022'], ['G04.468.160'], ['G02.111.263', 'G03.328'], ['D04.210.500.496'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408.495.500', 'D12.776.543.750.705.408.600.500', 'D12.776.543.750.705.833.500'], ['A11.118.637.415.583', 'A11.627... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Toxicity study of oxalicumone A, derived from a marine-derived fungus Penicillium oxalicum, in cultured renal epithelial cells. | Oxalicumone A (POA), a novel dihydrothiophene-condensed chromone, was isolated from the marine‑derived fungus Penicillium oxalicum. Previous reports demonstrated that POA exhibits strong activity against human carcinoma cells, thus it has been suggested as a bioactive anticancer agent. To research the toxic effect of P... | ['Acetylglucosaminidase', 'Apoptosis', 'Caspase 3', 'Cell Line', 'Chromones', 'Epithelial Cells', 'Humans', 'Kidney', 'L-Lactate Dehydrogenase', 'Malondialdehyde', 'Membrane Potential, Mitochondrial', 'Nitric Oxide', 'Penicillium', 'Proto-Oncogene Proteins c-bcl-2', 'Reactive Oxygen Species', 'Superoxide Dismutase', 'b... | 28,260,084 | [['D08.811.277.450.483.180.500'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251.210'], ['D03.383.663.283.266', 'D03.633.100.150.266'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
FAK regulates cardiomyocyte survival following ischemia/reperfusion. | Myocyte apoptosis is central to myocardial dysfunction following ischemia/reperfusion (I/R) and during the transition from hypertrophy to heart failure. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase regulates adhesion-dependent survival signals and unopposed FAK activation has been linked to tumor develop... | ['Animals', 'Apoptosis', 'Blotting, Western', 'Focal Adhesion Kinase 1', 'Focal Adhesion Protein-Tyrosine Kinases', 'Mice', 'Mice, Mutant Strains', 'Myocardial Reperfusion Injury', 'Myocytes, Cardiac', 'NF-kappa B', 'Reperfusion Injury', 'Reverse Transcriptase Polymerase Chain Reaction', 'Signal Transduction'] | 19,028,502 | [['B01.050'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D08.811.913.696.620.682.725.049.500', 'D12.776.744.493'], ['D08.811.913.696.620.682.725.049', 'D12.644.360.287', 'D12.776.476.287'], ['B01.050.150.900.649.313.992.635.505.500'], ['B0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Infective endocarditis in a tertiary-care hospital in southern Israel. | During the years 1980-1994, 84 patients were treated in our institution due to suspected infective endocarditis (IE). Seventy-one of these episodes occurring in 71 patients, classified definite or possible according to the Duke criteria, were retrospectively analyzed in this study. There were 52 cases of native valve e... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Diagnosis, Differential', 'Endocarditis, Bacterial', 'Female', 'Heart Valve Prosthesis', 'Hospitals, Community', 'Humans', 'Israel', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies', 'Rheumatic Heart Disease', 'Severity of Illness Index', 'Staphylococcus ... | 10,641,529 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.171'], ['C01.150.252.245', 'C01.190.249', 'C14.260.249', 'C14.280.282.407'], ['E07.695.310'], ['N02.278.421.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375'], ['M01.060.116.630'], ['E01.789'], ['E05.318.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
MicroRNA-133 controls cardiac hypertrophy. | Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell functions and oncogenesis. Here we report that miR-133 has a critical role in determining cardiomyocyte hypertrophy. We observed decreased expression of both miR-133 and miR-1, which belong to the same transcriptional unit, in mouse a... | ['Animals', 'Aorta, Thoracic', 'Cardiomegaly', 'Disease Models, Animal', 'Humans', 'Mice', 'Mice, Transgenic', 'MicroRNAs', 'Molecular Sequence Data', 'Oligonucleotide Array Sequence Analysis', 'Oncogene Protein v-akt', 'Rats'] | 17,468,766 | [['B01.050'], ['A07.015.114.056.372'], ['C14.280.195', 'C23.300.775.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['D13.150.650.319', 'D13.444.735... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Self-Reported Sleep Disturbance from Road, Rail and Aircraft Noise: Exposure-Response Relationships and Effect Modifiers in the SiRENE Study. | This survey investigates the cross-sectional association between nighttime road, rail and aircraft noise exposure and the probability to be highly sleep disturbed (%HSD), as measured by self-report in postal and online questionnaires. As part of the Swiss SiRENE study, a total of 5592 survey participants in the entire ... | ['Adult', 'Aged', 'Aircraft', 'Animals', 'Cross-Sectional Studies', 'Environmental Exposure', 'Female', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Noise, Transportation', 'Railroads', 'Self Report', 'Sleep Wake Disorders', 'Surveys and Questionnaires', 'Switzerland', 'Young Adult'] | 31,671,890 | [['M01.060.116'], ['M01.060.116.100'], ['J01.937.285.100'], ['B01.050'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Visual search in breast imaging. | Breast cancer is the most common cancer among females worldwide and large volumes of breast images are produced and interpreted annually. As long as radiologists interpret these images, the diagnostic accuracy will be limited by human factors and both false-positive and false-negative errors might occur. By understandi... | ['Attention', 'Breast', 'Breast Neoplasms', 'Deep Learning', 'Diagnosis, Computer-Assisted', 'Diagnostic Errors', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Mammography', 'Pattern Recognition, Visual', 'Radiologists', 'Research', 'Ultrasonography, Mammary'] | 31,287,719 | [['F02.830.104.214'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['G17.035.250.500.250', 'G17.485.500', 'L01.224.050.375.530.250', 'L01.224.050.375.605.500'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.354', 'N02.421.450.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E01.370... | ['Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Imperfect surface order and functionalization in vertical carbon nanotube arrays probed by near edge X-ray absorption fine structure spectroscopy (NEXAFS). | Probing surface order as well as the degree of structural modification in carbon nanotube systems is of fundamental importance for incorporation of these materials into practical functional devices. The current study pertains to the analysis of the surface order of vertically-aligned single-walled and multi-walled carb... | ['Carbon', 'Chemistry, Physical', 'Electrochemistry', 'Electrons', 'Microscopy, Electron, Scanning', 'Nanotubes', 'Nanotubes, Carbon', 'Photons', 'Spectrometry, X-Ray Emission', 'Surface Properties'] | 17,091,154 | [['D01.268.150'], ['H01.181.529'], ['H01.181.529.307'], ['G01.249.335', 'G01.358.500.750'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['J01.637.512.850'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['G01.249.705', 'G01.358.500.505.650.782', 'G01.590.540.782', 'G01.750.250.650.782', 'G01.750.770.578.782'], ['... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Characterization of choline uptake in prostate cancer cells following bicalutamide and docetaxel treatment. | PURPOSE: Choline derivatives labelled with positron emitters are successfully used for PET imaging of prostate cancer patients. Since little is known about uptake mechanisms, the aim of this study was to characterize choline uptake in prostate cancer cells, also following anti-androgen treatment or chemotherapy.METHODS... | ['Androgen Antagonists', 'Anilides', 'Antineoplastic Agents', 'Biological Transport', 'Cell Line, Tumor', 'Choline', 'Diffusion', 'Docetaxel', 'Hemicholinium 3', 'Humans', 'Male', 'Nitriles', 'Organic Cation Transport Proteins', 'Positron-Emission Tomography', 'Prostatic Neoplasms', 'Radiopharmaceuticals', 'Taxoids', '... | 19,352,653 | [['D06.347.065', 'D27.505.696.399.450.065'], ['D02.065.199', 'D02.092.146.113'], ['D27.505.954.248'], ['G03.143'], ['A11.251.210.190', 'A11.251.860.180'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['G01.202', 'G02.196'], ['D02.455.426.392.368.242.888.389', 'D02.455.849.29... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mobilization of sarcoplasmic reticulum stores by hypoxia leads to consequent activation of capacitative Ca2+ entry in isolated canine pulmonary arterial smooth muscle cells. | Capacitative Ca2+ entry (CCE) has been speculated to contribute to Ca2+ influx during hypoxic pulmonary vasoconstriction (HPV). The aim of the present study was to directly test if acute hypoxia causes intracellular Ca2+ concentration ([Ca2+]i) rises through CCE in canine pulmonary artery smooth muscle cells (PASMCs). ... | ['Animals', 'Calcium', 'Calcium Channel Blockers', 'Cell Hypoxia', 'Dogs', 'Female', 'In Vitro Techniques', 'Ionomycin', 'Male', 'Muscle, Smooth, Vascular', 'Nisoldipine', 'Pulmonary Artery', 'Sarcoplasmic Reticulum', 'Vasoconstriction'] | 15,613,369 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['G03.197.300', 'G04.270.300'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.481'], ['D10.251.355.391'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['D03.383.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
EMG computerized analysis of localized fatigue in Duchenne muscular dystrophy. | EMG power spectra obtained during a sustained isometric contraction were analyzed in a group of 10 children affected by Duchenne muscular dystrophy (DMD) and compared with those obtained in a control group of 5 normal children. In myopathic subjects the isometric contraction caused an increase of the total power, a pro... | ['Child', 'Diagnosis, Computer-Assisted', 'Electromyography', 'Humans', 'Isometric Contraction', 'Male', 'Muscle Contraction', 'Muscles', 'Muscular Dystrophies'] | 3,043,217 | [['M01.060.406'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494.472'], ['G11.427.494'], ['A02.633', 'A10.690'], ['C05.651.534.500', 'C10.668.491.175.500', 'C16.320.577']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Tanis: a link between type 2 diabetes and inflammation? | Here we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin le... | ['Amino Acid Sequence', 'Animals', 'Apolipoproteins', 'Base Sequence', 'Blood Glucose', 'Chromosome Mapping', 'Chromosomes, Human, Pair 15', 'Diabetes Mellitus, Type 2', 'Exons', 'Gene Expression', 'Gerbillinae', 'Glucose', 'Glycosylation', 'Humans', 'Inflammation', 'Liver', 'Membrane Proteins', 'Molecular Sequence Dat... | 12,031,974 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D10.532.091', 'D12.776.070.400', 'D12.776.521.120'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D09.947.875.359.448.500'], ['E05.393.183'], ['A11.284.187.520.300.370.385', 'G05.360.162.520.300.370.385'], ['C18.452.394.750.149', 'C19.246.300']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Eligibility requirements in hypnotic trials. | Forty-eight patients complaining of insomnia were studied at two sleep laboratories using an identical protocol to evaluate hypnotic efficacy. All met the screening requirement of a mean sleep latency of 30 min or greater on 3 laboratory nights following an adaptation night. Of these patients 34 still complaining of in... | ['Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Hypnosis', 'Male', 'Middle Aged', 'Reaction Time', 'Sleep Initiation and Maintenance Disorders', 'Sleep Stages', 'Sleep, REM'] | 3,992,107 | [['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.217', 'F04.754.424'], ['M01.060.116.630'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['C10.886.425.800.800', 'F03.870.400.800.80... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prospective evaluation of the systemic inflammatory marker C-reactive protein in patients with end-stage periodontitis getting teeth replaced with dental implants: a pilot investigation. | OBJECTIVES: Serum C-reactive protein (CRP) has been shown to be a risk predictor for cardiovascular disease. Periodontal treatment reduces elevated CRP levels. The aim of this pilot investigation was to evaluate if dental implants placed after extractions in patients with end-stage periodontitis affect the serum CRP le... | ['Aged', 'Analysis of Variance', 'C-Reactive Protein', 'Dental Implantation, Endosseous', 'Dental Implants', 'Female', 'Humans', 'Male', 'Middle Aged', 'Periodontitis', 'Pilot Projects', 'Prospective Studies', 'Time Factors', 'Tooth Extraction'] | 15,642,040 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['B0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Predictors of full enteral feeding achievement in very low birth weight infants. | BACKGROUND: To elucidate the role of prenatal, neonatal and early postnatal variables in influencing the achievement of full enteral feeding (FEF) in very low birth weight (VLBW) infants and to determine whether neonatal intensive care units (NICUs) differ in this outcome.METHODS: Population-based retrospective cohort ... | ['Cohort Studies', 'Enteral Nutrition', 'Female', 'Humans', 'Infant, Newborn', 'Infant, Very Low Birth Weight', 'Intensive Care Units, Neonatal', 'Male', 'Time Factors'] | 24,647,523 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.421.360', 'E02.642.500.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.460.600'], ['N02.278.388.493.390.380'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Endovesical ultrasonography of urachal carcinoma. | We describe a case of adenocarcinoma of the urachus in which endovesical ultrasonography was used preoperatively to assess accurately the nature and extent of the neoplasm. Endovesical ultrasonography is a simple and safe technique that may be of value in the routine evaluation of invasive bladder neoplasms. | ['Adenocarcinoma', 'Diagnosis, Differential', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Tomography, X-Ray Computed', 'Ultrasonography', 'Urachus', 'Urinary Bladder Neoplasms'] | 2,660,384 | [['C04.557.470.200.025'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['E01.370.350.850'], ['A16.890'], ['C04.588.945.947.960', 'C12.75... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chrysotile asbestos and health in Zimbabwe: II. Health status survey of active miners and millers. | As part of the effort to establish industrial practice and public policy regarding asbestos in Zimbabwe, we have conducted a cross-sectional study of the chrysotile mines and mills. A stratified random sample of workers with greater than 10 years of exposure has been evaluated by spirometry, chest radiographs, and empl... | ['Asbestos', 'Asbestos, Serpentine', 'Asbestosis', 'Cross-Sectional Studies', 'Health Status', 'Humans', 'Male', 'Maximum Allowable Concentration', 'Mining', 'Occupational Exposure', 'Respiratory Function Tests', 'Risk Factors', 'Time Factors', 'Zimbabwe'] | 1,847,002 | [['D01.578.725.050', 'D01.837.725.700.760.070'], ['D01.524.500.050', 'D01.578.725.050.075', 'D01.578.725.500.050', 'D01.837.725.700.760.070.110', 'D01.837.725.700.760.535.400'], ['C08.381.483.581.125', 'C08.381.520.702.125', 'C24.800.127'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
High serum allopregnanolone levels in girls with precocious puberty. | Allopregnanolone, a circulating neuroactive steroid hormone, is involved in the modulation of behavioral functions, stress, and the neuroendocrine axis. The aim of this study was to evaluate serum allopregnanolone concentrations in girls with central precocious puberty (n = 12), girls with normal pubertal development a... | ['Adrenocorticotropic Hormone', 'Child', 'Female', 'Gonadotropin-Releasing Hormone', 'Humans', 'Osmolar Concentration', 'Pregnanolone', 'Puberty', 'Puberty, Precocious', 'Reference Values'] | 11,994,373 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['M01.060.406'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', '... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The gene encoding rat liver glycogen phosphorylase contains multiple polyadenylation signal sequences. | RNA blot analysis of rat liver and adipose tissues detected two glycogen phosphorylase (GP)-encoding transcripts. The polymerase chain reaction was used to characterize the 3'-noncoding region of the gene (L-GP) encoding liver-GP (L-GP) from the lean Zucker rat (Fa/Fa). Three distinct classes of colinear cDNA clones we... | ['Adipose Tissue', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Blotting, Southern', 'Liver', 'Molecular Sequence Data', 'Phosphorylases', 'Poly A', 'Polymerase Chain Reaction', 'Rats', 'Rats, Zucker', 'Restriction Mapping'] | 1,765,272 | [['A10.165.114'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['A03.620'], ['L01.453.245.667'], ['D08.811.913.400.450.460.400'], ['D13.695.578.550.500'], ['E05.393.620.500'], ['B01.050.150.900.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Exposure of Gambian children to Anopheles gambiae malaria vectors in an irrigated rice production area. | Variation in exposure of children to malaria vectors of the Anopheles gambiae complex was recorded in a Gambian village situated near an irrigated area of rice cultivation. Observations were made in 1987 and 1988 during two dry seasons, when pumped water was used to grow rice, and two rainy seasons, when rice was produ... | ['Agriculture', 'Animals', 'Anopheles', 'Child', 'Environmental Exposure', 'Gambia', 'Humans', 'Insect Bites and Stings', 'Insect Vectors', 'Malaria', 'Oryza', 'Population Surveillance', 'Regression Analysis', 'Risk Factors'] | 7,696,688 | [['J01.040'], ['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.875.120'], ['M01.060.406'], ['N06.850.460.350'], ['Z01.058.290.190.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C25.723.127.071', 'C26.176.143'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['C01.610.752.530', 'C01.920... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
The diagnosis of congenital hip-joint dislocation by the ultrasonic Combound treatment. | Due to poor penetration of bone, ultrasonic techniques have not been popular in orthropedic procedures. Since they are non-invasive and are not associated with a radiation hazard, their application in the diagnosis of congenital hip-joint dislocations merits investigation. Methods are presented in Part I which should e... | ['Child, Preschool', 'Hip Dislocation, Congenital', 'Hip Joint', 'Humans', 'Infant', 'Radiography', 'Ultrasonics', 'Ultrasonography'] | 7,458,597 | [['M01.060.406.448'], ['C05.660.297.500', 'C16.131.621.297.500', 'C16.131.621.449'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.350.700'], ['H01.671.031.849'], ['E01.370.350.850']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Intrauterine insemination in fertile women delivers larger number of sperm to the peritoneal fluid than intracervical insemination. | Randomized IUI or intracervical insemination of eight fertile women with 50 x 10(6) sperm was performed to determine whether IUI delivers more spermatozoa to the peritoneal cavity. After IUI (n = 4), 2,053 to 29,450 sperm were recovered in the PF at laparoscopy. No sperm were found in the PF after intracervical insemin... | ['Cervix Uteri', 'Female', 'Humans', 'Insemination, Artificial', 'Male', 'Peritoneal Cavity', 'Sperm Count', 'Spermatozoa', 'Uterus'] | 8,299,805 | [['A05.360.319.679.256'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.875.800.937', 'E05.820.800.937', 'G08.686.784.363.492'], ['A01.923.047.025.600.678'], ['E01.370.225.500.195.870', 'E01.370.225.992.624', 'E05.200.500.195.870', 'E05.200.992.624', 'E05.242.195.870', 'G04.140.870'], ['A05.360.490.890', 'A11.... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantification of morphologic and hemodynamic severity of coarctation of the aorta by magnetic resonance imaging. | OBJECTIVE: As the morpholgic severity of coarctation of the aorta is difficult to assess, especially after previous repair, the value of the technique of multiplanar reconstruction of magnetic resonance imaging data to achieve a 3-dimensional reconstruction of the aortic arch was evaluated and compared to hemodynamic m... | ['Adolescent', 'Adult', 'Angiography', 'Aortic Coarctation', 'Child', 'Collateral Circulation', 'Female', 'Hemodynamics', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Linear Models', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Pressure', 'Severity of Illness Index'] | 11,727,906 | [['M01.060.057'], ['M01.060.116'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C14.240.400.090', 'C14.280.400.090', 'C16.131.240.400.090'], ['M01.060.406'], ['G09.330.100.248'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['E05.318.740.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Comparison of immunodiffusion and crossed-immunoelectrophoresis in the diagnosis of invasive candidiasis. | A retrospective single blind study was conducted to compare the efficacy of crossed-immunoelectrophoresis using concanavalin A intermediate gel with double immunodiffusion tests in the diagnosis of invasive candidiasis. On the basis of cytoplasmic antibody detection, crossed-immunoelectrophoresis with concanavalin A di... | ['Adolescent', 'Adult', 'Aged', 'Candida', 'Candida albicans', 'Candidiasis', 'Female', 'Humans', 'Immunodiffusion', 'Immunoelectrophoresis, Two-Dimensional', 'Male', 'Middle Aged'] | 6,411,463 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['C01.150.703.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.735.645.350', 'E05.200.812.735.645.350... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Optical internal urethrotomy as the treatment of choice for primary stricture of the urethra. | Seventy-five patients with primary urethral strictures were treated by optical urethrotomy with catheter drainage for 7 days. Good results were obtained in 66% of cases, which were all post-traumatic in nature; 34% had to undergo further procedures such as dilatation or repeat internal urethrotomy. | ['Adult', 'Aged', 'Cystoscopy', 'Dilatation', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Reoperation', 'Urethra', 'Urethral Stricture', 'Urinary Catheterization', 'Urination'] | 3,191,341 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.388.250.180', 'E01.370.390.175', 'E04.502.250.180', 'E04.950.774.155'], ['E05.284'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E04.690'], ['A05.360.44... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Exquisite food allergy without eating. | The past few decades have witnessed an increasing understanding of the role of food allergy in human disease. Nevertheless, controversies still exist in several aspects of this area. One such controversy concerns the body systems that can be the target of food hypersensitivity reactions. Another is the role of noninges... | ['Child', 'Food Hypersensitivity', 'Humans', 'Male'] | 8,172,359 | [['M01.060.406'], ['C20.543.480.370'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Helicobacter pylori: a scientific paradigm?]. | It is analyzed from a historic philosophic view, the role which takes the discovery of the Helicobacter pylori as an example like the way scientists proceed to build the scientific knowledge. The method for the philosophic interpretation of this find is based on the proposal of Thomas Kuhn who offers a historical descr... | ['Duodenal Ulcer', 'Gastritis', 'Helicobacter Infections', 'Helicobacter pylori', 'History, 20th Century', 'Humans', 'Research'] | 8,018,903 | [['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['C06.405.205.697', 'C06.405.748.398'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644']] | ['Diseases [C]', 'Organisms [B]', 'Humanities [K]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[CT-guided radiofrequency ablation of liver metastases from colorectal cancer]. | BACKGROUND AND OBJECTIVE: Data on radiofrequency ablation (RFA) of liver metastasis has not been uniform. The goal of this study was to determine medium-term success of CT-guided RFA of liver metastases from colorectal cancer.PATIENTS AND METHODS: 43 consecutive patients (27 men; aged 67+/-10 years) with a total of 87 ... | ['Aged', 'Aged, 80 and over', 'Catheter Ablation', 'Colorectal Neoplasms', 'Disease Progression', 'Female', 'Humans', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Retrospective Studies', 'Risk Factors', 'Survival Rate', 'Tomography, X-Ray Computed'] | 19,401,962 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.808.750.500', 'E04.014.760.500'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions. | INTRODUCTION: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q10 (CoQ10) supplementation on the ethanol-induced gastric mucosal damage in a rat model.MATERIAL AND METHOD: Sixty-four female wistar albino rats were randomly divi... | ['Animals', 'Anti-Ulcer Agents', 'Dose-Response Relationship, Drug', 'Ethanol', 'Female', 'Gastric Mucosa', 'Plant Extracts', 'Random Allocation', 'Rats', 'Rats, Wistar', 'Stomach Ulcer', 'Ubiquinone', 'Vitamins'] | 25,666,963 | [['B01.050'], ['D27.505.954.483.203'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.033.375'], ['A03.556.875.875.440', 'A10.615.550.291'], ['D20.215.784.500', 'D26.667'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A cotton (Gossypium hirsutum) gene encoding a NAC transcription factor is involved in negative regulation of plant xylem development. | NAC proteins that compose of one large family of plant specific transcription factors (TF) play the important roles in many biological processes (such as morphogenesis, development, senescence and stress signal transduction). In this study, a gene (designated as GhXND1) encoding a NAC transcription factor was identifie... | ['Amino Acid Sequence', 'Gene Expression Regulation, Plant', 'Genes, Plant', 'Gossypium', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid', 'Transcription Factors', 'Xylem'] | 25,137,291 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G05.308.375'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['L01.453.245.667'], ['G02.111.810.200', 'G05.810.200'], ['D12.776.930'], ['A18.450.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Sensorimotor reactions in students of high school age during different types of the weather]. | The neuro-dynamical characteristics of the higher nervous activity of senior pupils in different weather types were investigated. The group of practically healthy pupils was given tests on investigation of the speed of the simple sensomotorical reaction (SSR), sigma of the simple sensomotorical reaction (Sigma), the me... | ['Adaptation, Physiological', 'Adolescent', 'Female', 'Higher Nervous Activity', 'Humans', 'Male', 'Psychomotor Performance', 'Reaction Time', 'Sex Factors', 'Visual Perception', 'Weather'] | 14,965,057 | [['G07.025', 'G16.012.500'], ['M01.060.057'], ['F02.463.247', 'G11.561.398'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['N05.715.350.675', 'N06.850.490.875'], ['F02.463.593.932'], ['G16.500.275.063.725', 'G1... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bobble-head doll syndrome due to a suprasellar arachnoid cyst: endoscopic treatment in two cases. | OBJECT: We report two cases of bobble-head doll syndrome associated with a large suprasellar arachnoid cyst successfully treated with a minimally invasive endoscopic approach.METHODS: The clinical history, surgical treatment and results of two children, a 9-year-old boy and a 1-year-old girl, both presenting the clinic... | ['Arachnoid Cysts', 'Cerebrospinal Fluid Shunts', 'Child', 'Endoscopy', 'Female', 'Head Movements', 'Humans', 'Hydrocephalus', 'Infant', 'Magnetic Resonance Imaging', 'Male', 'Movement Disorders'] | 15,057,560 | [['C04.182.044', 'C04.588.614.250.387.100', 'C10.500.142.100', 'C10.551.240.375.100', 'C16.131.666.142.100'], ['E04.035.188', 'E04.525.170'], ['M01.060.406'], ['E01.370.388.250', 'E04.502.250'], ['G11.427.410.478'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.602'], ['M01.060.703'], ['E01.370.350.825... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Less is more: reduced catechol production permits Pseudomonas putida F1 to grow on styrene. | Pseudomonas putida F1 is unable to grow on styrene due to the accumulation of 3-vinylcatechol, a toxic metabolite that is produced through the toluene degradation (tod) pathway and causes catechol-2,3-dioxygenase (C23O) inactivation. In this study, we characterized a spontaneous F1 mutant, designated SF1, which acquire... | ['Bacterial Proteins', 'Catechol 2,3-Dioxygenase', 'Catechols', 'Mutation', 'Oxygenases', 'Pseudomonas putida', 'Styrene', 'Toluene'] | 22,902,727 | [['D12.776.097'], ['D08.811.682.690.416.305'], ['D02.455.426.559.389.657.166'], ['G05.365.590'], ['D08.811.682.690'], ['B03.440.400.425.625.625.675', 'B03.660.250.580.590.580'], ['D02.455.426.559.389.150.750.800'], ['D02.455.426.559.389.832']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation of a complex of dexamethasone palmitate-low density lipoprotein and its effect on foam cell formation of murine peritoneal macrophages. | In the early progression of atherosclerosis, LDL migrates in the subendothelial space of the artery and plays an important role in foam cell formations of macrophages. LDL may serve as a carrier of site-specific delivery of drugs to atherosclerotic lesions. In this exploratory study, dexamethasone palmitate (DP) was in... | ['Animals', 'Arteriosclerosis', 'Cholesterol Esters', 'Dexamethasone', 'Drug Delivery Systems', 'Foam Cells', 'Lipoproteins, LDL', 'Macrophages, Peritoneal', 'Male', 'Mice', 'Mice, Inbred ICR', 'Palmitates'] | 10,393,569 | [['B01.050'], ['C14.907.137.126'], ['D04.210.500.247.222.284.200', 'D04.210.500.247.808.197.200', 'D10.570.938.208.250'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['E02.319.300'], ['A11.329.372.368', 'A11.627.482.368', 'A11.733.397.368', 'A15.382.670.522.368', 'A15.382.680.397.368'], ['D10.532.515', 'D12... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Social functioning of schizophrenia patients without working capability]. | The social functioning is an important criteria for evaluation when the decision about guardianship has to be made. Therefore, we investigated the differences in social functioning of persons under guardianship in comparison with persons without guardianship. Examinees (N=123) with diagnosed schizophrenia, accommodated... | ['Adult', 'Female', 'Humans', 'Legal Guardians', 'Male', 'Middle Aged', 'Schizophrenic Psychology', 'Social Adjustment', 'Social Behavior'] | 19,469,272 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.380'], ['M01.060.116.630'], ['F04.824'], ['F01.145.813.621'], ['F01.145.813']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Response of immunoreactive antiarrhythmic peptide (IR-AAP) level associated with experimental arrhythmia in rats. | The change in endogenous antiarrhythmic peptide (AAP) levels in serum, heart and kidney from rats under several drug-induced arrhythmias was investigated using a sensitive and specific radioimmunoassay. The extracts from serum, heart and kidney were fractionated by Sephadex G-25 chromatography to obtain a fraction whic... | ['Aconitine', 'Adenosine Diphosphate', 'Animals', 'Anti-Arrhythmia Agents', 'Arrhythmias, Cardiac', 'Calcium Chloride', 'Epinephrine', 'Oligopeptides', 'Radioimmunoassay', 'Rats'] | 3,820,057 | [['D02.455.849.291.184.037', 'D03.132.301.030'], ['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['B01.050'], ['D27.505.954.411.097'], ['C14.280.067', 'C23.550.073'], ['D01.146.300', 'D01.210.450.150.150'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variability of NSQIP-assessed surgical quality based on age and disease process. | BACKGROUND: Recent national attention has focused on improving upon the surgical quality of hospitals across the United States. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database includes expected morbidity probability for each surgical patient. We sought to investigate ... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Databases, Factual', 'Diagnosis-Related Groups', 'Female', 'General Surgery', 'Humans', 'Male', 'Middle Aged', 'Quality Assurance, Health Care'] | 23,290,529 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['N03.219.521.710.305.200.080'], ['H02.403.810.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.761.700', 'N05.700']] | ['Named Groups [M]', 'Health Care [N]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Sense of coherence and parenting stress in mothers and fathers of preschool children with developmental disability. | BACKGROUND: Few previous studies have examined Antonovsky's (1979, 1987) sense of coherence (SOC) in parents of young children with developmental disability (DD). This study explored relationships between parental stress, SOC, social support, and health in parents of preschool children with and without DD. A secondary ... | ['Adaptation, Psychological', 'Adult', 'Child, Preschool', 'Cost of Illness', 'Developmental Disabilities', 'Fathers', 'Female', 'Humans', 'Male', 'Models, Psychological', 'Mothers', 'Parenting', 'Personality Inventory', 'Problem Solving', 'Psychometrics', 'Stress, Psychological', 'Surveys and Questionnaires'] | 16,766,317 | [['F01.058'], ['M01.060.116'], ['M01.060.406.448'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['F03.625.421'], ['F01.829.263.500.320.100', 'I01.880.853.150.500.340.210', 'M01.620.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['F01.829.263.500.3... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Resection of a dysembryoplastic neuroepithelial tumor in the precentral gyrus. | BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNTs) are common causes of intractable epilepsy in pediatric epilepsy patients. The effect of surgical intervention is often limited when the tumor is located in the precentral gyrus. Furthermore, complete surgical resection is often not performed in order to avoid p... | ['Brain Neoplasms', 'Child', 'Craniotomy', 'Electroencephalography', 'Epilepsy', 'Frontal Lobe', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Neoplasms, Neuroepithelial', 'Neurosurgical Procedures', 'Postoperative Care', 'Prognosis', 'Risk Assessment', 'Treatment Outcome'] | 26,253,415 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['E04.525.190'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['A08.186.211.200.885.287.500.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C04.557.465.625.600', 'C04.557.470.670', 'C04.55... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. | OBJECTIVE: To prepare, sequence and analyse adult human cartilage cDNA libraries to study the gene expression pattern between normal and osteoarthritic cartilage.METHODS: Poly A(+)RNA from adult human normal and osteoarthritic articular cartilage was isolated and used to prepare cDNA libraries. Approximately 5000 ESTs ... | ['Adult', 'Blotting, Northern', 'Cartilage, Articular', 'Case-Control Studies', 'Expressed Sequence Tags', 'Gene Expression', 'Gene Library', 'Humans', 'In Situ Hybridization', 'Molecular Sequence Data', 'Osteoarthritis, Knee'] | 11,597,177 | [['M01.060.116'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A02.165.407.150', 'A02.835.583.192'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G05.360.340.024.340.137.275'], ['G05.297'], ['G05.360.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.50... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
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