Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Functional properties of partially oxidized trout hemoglobins. | This paper reports on a study of the effect of partial oxidation on oxygen and carbon monoxide binding by components I and IV of trout hemoglobin. The O2 binding equilibria of the various oxidation mixtures show a decrease in the heme-heme interactions as the number of oxidized sites is increased. However, the large Bo... | ['Animals', 'Azides', 'Carbon Monoxide', 'Carboxyhemoglobin', 'Hemoglobins', 'Hydrogen-Ion Concentration', 'Kinetics', 'Oxidation-Reduction', 'Oxygen', 'Oxyhemoglobins', 'Protein Conformation', 'Salmonidae', 'Structure-Activity Relationship', 'Trout'] | 13,851 | [['B01.050'], ['D01.625.100', 'D02.159'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['D12.776.124.400.141', 'D12.776.422.316.762.149'], ['D12.776.124.400', 'D12.776.422.316.762'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['G02.700', 'G03.295.531'], ['D01.268.185.550', 'D01.362.670'], ['D12.776.124.400.707'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inadequate glucose control in type 2 diabetes is associated with impaired lung function and systemic inflammation: a cross-sectional study. | BACKGROUND: Inadequate glucose control may be simultaneously associated with inflammation and decreased lung function in type 2 diabetes. We evaluated if lung function is worse in patients with inadequate glucose control, and if inflammatory markers are simultaneously increased in these subjects.METHODS: Subjects were ... | ['Adult', 'Aged', 'Biomarkers', 'Blood Glucose', 'C-Reactive Protein', 'Cross-Sectional Studies', 'Diabetes Mellitus, Type 2', 'Female', 'Ferritins', 'Fibrinogen', 'Glycated Hemoglobin A', 'Humans', 'Hyperglycemia', 'Inflammation', 'Interleukin-6', 'Lung Diseases', 'Male', 'Middle Aged', 'Respiratory Function Tests', '... | 20,659,337 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['D09.947.875.359.448.500'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C18.452.394.750.149', 'C19.246.300'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['D12... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The contribution of handsearching European general health care journals to the Cochrane Controlled Trials Register. | A fundamental aim of any systematic review is that all relevant studies should be identified and considered for inclusion. Limitations with searching bibliographic databases led the Cochrane Collaboration to search journals by hand for reports of trials. This article presents the results of a 3-year project to identify... | ['Abstracting and Indexing', 'Databases, Bibliographic', 'Europe', 'Evidence-Based Medicine', 'Humans', 'Information Services', 'Information Storage and Retrieval', 'International Cooperation', 'MEDLINE', 'Organizations, Nonprofit', 'Periodicals as Topic', 'Randomized Controlled Trials as Topic'] | 11,868,446 | [['L01.453.245.100'], ['L01.313.500.750.300.188.300', 'L01.470.750.500'], ['Z01.542'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453'], ['L01.313.500.750.280', 'L01.470'], ['I01.615.500'], ['L01.313.500.750.280.710.500', 'L01.313.500.750.280.750.500', 'L01.313.500.750.30... | ['Information Science [L]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Lower Frequency of HLA-DRB1*01 in Southwestern Iranian Patients with Atherosclerosis. | BACKGROUND: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antigen Presentation', 'Atherosclerosis', 'Cross-Sectional Studies', 'Female', 'Gene Frequency', 'Genetic Association Studies', 'Genotype', 'HLA-DRB1 Chains', 'Humans', 'Hypertension', 'Iran', 'Male', 'Middle Aged', 'Polymorphism, Genetic'] | 30,246,695 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G12.119', 'G12.450.050.400.070'], ['C14.907.137.126.307'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G05.330'], ['E05.393.385'], ['G05.380'], ['D12.776.395.550.509.400.440.200.010', 'D12.776.543.550.440.400.440.200.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Missed pulmonary embolism on abdominal CT. | OBJECTIVE: The purpose of this study is to evaluate a series of missed pulmonary emboli (PE) identified on abdominal CT and to describe their characteristics and the clinical scenario.MATERIALS AND METHODS: All reports of chest CT scans performed during a 12-month period were searched for keywords indicative of PE. Amo... | ['Adult', 'Aged', 'Aged, 80 and over', 'Contrast Media', 'Diagnostic Errors', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pulmonary Embolism', 'Tomography, X-Ray Computed'] | 24,660,700 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.259.500', 'D27.720.259'], ['E01.354', 'N02.421.450.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C08.381.746', 'C14.907.355.350.700'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.81... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Quality of bevacizumab (Avastin®) repacked in single-use glass vials for intravitreal administration. | Purpose:: Avastin® (bevacizumab) is an anti-vascular endothelial growth factor (VEGF) monoclonal antibody given as an off-label drug by intravitreal administration for treatment of ocular diseases. The drug's clinical application and its cost-benefit profile has generated demand for its division into single-use vials t... | ['Angiogenesis Inhibitors', 'Bevacizumab', 'Chromatography, Gel', 'Drug Packaging', 'Drug Stability', 'Dynamic Light Scattering', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme-Linked Immunosorbent Assay', 'Intravitreal Injections', 'Molecular Weight', 'Nephelometry and Turbidimetry', 'Quality Control', 'Vascular Endot... | 28,591,284 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D12.776.124.486.485.114.224.060.375', 'D12.776.124.790.651.114.224.060.438', 'D12.776.377.715.548.114.224.200.438'], ['E05.196.181.400.250'], ['E05.916.320', 'J01.576.655.750.321', 'J01.576.761.300'], ['E05.916.330'], ['E05.196.822.325'],... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Echo detection and target-ranging neurons in the auditory system of the bat Eptesicus fuscus. | Some of the neurons in the nucleus intercollicularis and auditory cortex of the echolocating bat Eptesicus fuscus respond selectively to sonar echoes occurring with specific echo delays or pulse-echo intervals. They do not respond for a wide range of other types of sounds or for sonar echoes at longer or shorter pulse-... | ['Animals', 'Auditory Cortex', 'Auditory Perception', 'Chiroptera', 'Echolocation', 'Inferior Colliculi', 'Neurons', 'Orientation'] | 705,350 | [['B01.050'], ['A08.186.211.200.885.287.500.814.249', 'A08.186.211.200.885.287.500.863.297'], ['F02.463.593.071', 'G07.888.125'], ['B01.050.150.900.649.313.937'], ['F01.145.113.055.400'], ['A08.186.211.132.659.800.407'], ['A08.675', 'A11.671'], ['F01.058.577', 'F02.830.606']] | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A study of goat SRY protein expression suggests putative new roles for this gene in the developing testis of a species with long-lasting SRY expression. | The testis-determining gene SRY is not well-conserved among mammals, and particularly between mouse and other mammals. To evaluate SRY function in a nonrodent species, we produced an antibody against goat SRY and used it to investigate the expression pattern of SRY throughout goat testicular development. By contrast wi... | ['Animals', 'Blotting, Western', 'COS Cells', 'Chlorocebus aethiops', 'Female', 'Gene Expression Regulation, Developmental', 'Goats', 'Male', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sertoli Cells', 'Sex Differentiation', 'Sex-Determining Region Y Protein', 'Spermatogonia', 'Testis'] | 20,941,779 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['G05.308.310'], ['B01.050.150.900.649.313.500.380.513'], ['E05.393.620.500.725'], ['A05.360.444.849.789... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serum protein analysis and bone marrow cytology in patients with an extreme elevation of the erythrocyte sedimentation rate. | One hundred patients in whom an Erythrocyte Sedimentation Rate (ESR) in excess of 100 mm. in the first hour was found on 2 consecutive occasions were investigated. Serum protein electrophoresis was performed on 96 of these patients and bone marrow examination on 55 patients. Acute infection was the commonest diagnosis ... | ['Adult', 'Aged', 'Blood Protein Electrophoresis', 'Blood Proteins', 'Blood Sedimentation', 'Bone Marrow', 'Bone Marrow Examination', 'Female', 'Humans', 'Male', 'Middle Aged'] | 644,295 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.124.100.110', 'E05.196.401.076', 'E05.200.124.100.110', 'E05.301.300.049'], ['D12.776.124'], ['E01.370.225.625.125', 'E05.200.625.125'], ['A15.382.216'], ['E01.370.225.625.135', 'E05.200.625.135'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Kinetics of CO binding to and dissociation from microsomal cytochrome P-450 induced by phenobarbital in rat liver. | The kinetics of CO binding to hepatic microsomes from phenobarbital-treated Sprague-Dawley rats, measured by stopped flow spectrophotometry, can be resolved into three components with second order velocity constants of 2.23 +/- 0.35 X 10(5) M-1 S-1, 1.59 +/- 0.18 X 10(6) M-1 S-1, and 8.7 +/- 1.7 X 10(6) M-1 S-1. The th... | ['Animals', 'Carbon Monoxide', 'Cytochrome P-450 Enzyme System', 'Kinetics', 'Male', 'Mathematics', 'Microsomes, Liver', 'Phenobarbital', 'Protein Binding', 'Rats'] | 659,421 | [['B01.050'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['A11.284.835.540.541'], ['D03.383.742.698.253.650'], ['G02.111.679', 'G03.808'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Complicated duodenal ulcer, vagotomy or distal resection--own experience. | An analysis of clinical material through 10-year-period (1980-1989) is presented. There were 708 gastric operations performed for gastroduodenal ulcer disease. Most frequently distal gastric resections (585) were used, 233 in B. I. and 352 in B II. modification. Selective proximal vagotomy (SPV) was less frequently use... | ['Duodenal Ulcer', 'Humans', 'Methods', 'Vagotomy, Proximal Gastric'] | 1,411,241 | [['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['E04.525.210.105.600.850.850']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. | BACKGROUND: Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trend toward benefit. We conducted two phase 3 studies of a protein-containing surfactant in adults with ARDS.METHODS: In two... | ['APACHE', 'Analysis of Variance', 'Causality', 'Double-Blind Method', 'Female', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Oxygen', 'Pulmonary Surfactant-Associated Protein C', 'Pulmonary Surfactants', 'Recombinant Proteins', 'Respiration, Artificial', 'Respiratory Distress Syndrome', 'Survival Rate', 'Treat... | 15,329,426 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['N05.715.350.200', 'N06.850.490.625'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.32... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immunohistological studies on an Onchocerca volvulus ankyrin (EI). | The distribution of an Onchocerca volvulus ankyrin, designated E1, was studied in different O. volvulus stages and other helminths by immunohistochemistry using rabbit antibodies raised against the recombinant E1 protein. In adult O. volvulus the protein designated E1 was localized to the extracellular clefts as well a... | ['Animals', 'Anthelmintics', 'Antibodies, Helminth', 'Female', 'Humans', 'Ivermectin', 'Male', 'Onchocerca volvulus', 'Onchocerciasis'] | 8,911,440 | [['B01.050'], ['D27.505.954.122.250.075'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.540.576.500.997'], ['B01.050.500.500.294.400.937.463.510.850'], ['C01.610.335.508.700.750.361.699', 'C01.610.858.650', 'C17.800... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of sex hormone-binding globulin in the human hypothalamus. | Gonadal steroids are known to influence hypothalamic functions through both genomic and non-genomic pathways. Sex hormone-binding globulin (SHBG) may act by a non-genomic mechanism independent of classical steroid receptors. Here we describe the immunocytochemical mapping of SHBG-containing neurons and nerve fibers in ... | ['Aged', 'Aged, 80 and over', 'Blotting, Western', 'Female', 'Humans', 'Hypothalamus', 'Immunohistochemistry', 'Male', 'Neurons', 'Sex Hormone-Binding Globulin', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 16,155,373 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association. | CONTEXT: DICER1 germline mutation carriers have an increased predisposition to cancer, such as pleuropulmonary blastoma (PPB) and Sertoli-Leydig cell tumor (SLCT), and a high prevalence of multinodular goiter (MNG). Although differentiated thyroid carcinoma (DTC) has been reported in some DICER1 mutation carriers with ... | ['Adenocarcinoma', 'Adolescent', 'Carcinoma', 'Carcinoma, Papillary', 'Child', 'DEAD-box RNA Helicases', 'Exons', 'Female', 'Focal Nodular Hyperplasia', 'Humans', 'Male', 'Mutation', 'Mutation, Missense', 'Pedigree', 'Ribonuclease III', 'Thyroid Cancer, Papillary', 'Thyroid Neoplasms', 'Thyroidectomy'] | 26,555,935 | [['C04.557.470.200.025'], ['M01.060.057'], ['C04.557.470.200'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['M01.060.406'], ['D08.811.913.696.445.735.720.249'], ['G05.360.340.024.340.137.232'], ['C06.552.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['G05.365.590.650'], ['E05.393.673'], ... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of root surface properties by fluorescence/Raman intensity ratio. | The aim of this study is to evaluate the existence of residual calculus on root surfaces by determining the fluorescence/Raman intensity ratio. Thirty-two extracted human teeth, partially covered with calculus on the root surface, were evaluated by using a portable Raman spectrophotometer, and a 785-nm, 100-mW laser wa... | ['Debridement', 'Dental Calculus', 'Fluorescence', 'Humans', 'Spectrum Analysis, Raman', 'Surface Properties', 'Tooth Root'] | 28,744,587 | [['E04.176'], ['C07.793.208.250', 'C23.300.175.350'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.822.860', 'E05.196.867.890'], ['G02.860'], ['A14.549.167.900.750']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy of Yokukansankachimpihange on sleep disturbance in Parkinson's disease: A study protocol of a randomized, double blind, placebo-controlled pilot trial. | INTRODUCTION: Parkinson's disease (PD) is a progressive neurodegenerative disorder that includes motor and nonmotor symptoms. Sleep disturbance is known to decrease the quality of life in patients with PD, and there are limitations to the pharmacotherapy currently in use. Therefore, complementary treatment therapies ar... | ['Double-Blind Method', 'Drugs, Chinese Herbal', 'Humans', 'Parkinson Disease', 'Polysomnography', 'Prospective Studies', 'Quality of Life', 'Research Design', 'Severity of Illness Index', 'Sleep Wake Disorders'] | 29,953,013 | [['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D20.215.784.500.350', 'D26.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.574.928.750'], ['E01.370.520.625'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Thermodynamic analysis of protein-ligand binding interactions in complex biological mixtures using the stability of proteins from rates of oxidation. | The detection and quantification of protein-ligand binding interactions is crucial in a number of different areas of biochemical research from fundamental studies of biological processes to drug discovery efforts. Described here is a protocol that can be used to identify the protein targets of biologically relevant lig... | ['Drug Discovery', 'Ligands', 'Oxidation-Reduction', 'Protein Stability', 'Proteins', 'Proteomics', 'Thermodynamics'] | 23,257,983 | [['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['D27.720.470.480'], ['G02.700', 'G03.295.531'], ['G02.111.700'], ['D12.776'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['G01.906']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (-)-lobeline in the rat brainstem. | Morphine, U50-488, and (-)-lobeline produced dose-related shortening of a low-intensity thermally evoked tail avoidance response (LITETAR) (e.g., hyperalgesia) when microinjected into the dorsal posterior mesencephalic tegmentum (DPMT) of conscious rats. The hyperalgesic potency of (-)-lobeline was greater than either ... | ['3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer', 'Analgesics', 'Animals', 'Dose-Response Relationship, Drug', 'Female', 'Lobeline', 'Microinjections', 'Morphine', 'Naltrexone', 'Pain', 'Pain Measurement', 'Pyrrolidines', 'Rats', 'Rats, Sprague-Dawley', 'Tegmentum Mesencephali... | 8,115,422 | [['D03.383.773.170'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['D03.132.478', 'D03.383.621.418'], ['E02.319.267.530.690', 'E05.591.570'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.723.795.576.571'], ['D03.132.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sevoflurane for difficult tracheal intubation. | Three patients in whom difficult tracheal intubation was expected but awake fibreoptic intubation was not feasible presented for head and neck surgery. Anaesthesia was induced rapidly and smoothly by inhalation of sevoflurane followed by fibreoptic or conventional tracheal intubation. | ['Adult', 'Aged', 'Anesthetics, Inhalation', 'Contraindications', 'Ethers', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Intubation, Intratracheal', 'Male', 'Methyl Ethers', 'Middle Aged', 'Parathyroidectomy', 'Sevoflurane'] | 9,389,864 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['E02.208'], ['D02.355'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['D02.355.601'], ['M01.060.116.630'], ['E04.270.694'], ['D02.355.601.810',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vitamins and perinatal outcomes among HIV-negative women in Tanzania. | BACKGROUND: Prematurity and low birth weight are associated with high perinatal and infant mortality, especially in developing countries. Maternal micronutrient deficiencies may contribute to these adverse outcomes.METHODS: In a double-blind trial in Dar es Salaam, Tanzania, we randomly assigned 8468 pregnant women (ge... | ['Abortion, Spontaneous', 'Adult', 'Ascorbic Acid', 'Birth Weight', 'Double-Blind Method', 'Female', 'Fetal Death', 'HIV Seronegativity', 'Humans', 'Incidence', 'Infant Mortality', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Infant, Small for Gestational Age', 'Pregnancy', 'Pregnancy Outcome', 'Premature Birth', 'T... | 17,409,323 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.116'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.32... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Age-related changes in the protein concentration gradient and the crystallin polypeptides of the lens. | With the use of a freeze-sectioning technique, the existence of a centripetal protein gradient in the rabbit lens is demonstrated. The steepness of this gradient (the difference in the protein concentration between periphery and the center) varies with age: it increases from a value of 40% in 6- to 8-month-old lenses t... | ['Adult', 'Aged', 'Aging', 'Animals', 'Body Water', 'Cataract', 'Child, Preschool', 'Crystallins', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Hydrolysis', 'Lens, Crystalline', 'Molecular Weight', 'Peptides', 'Rabbits', 'Sodium Dodecyl Sulfate'] | 7,076,406 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['B01.050'], ['A12.207.200'], ['C11.510.245'], ['M01.060.406.448'], ['D12.776.306.366'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['A09.371.060.500'], ['G02.494'], ['D12.644'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sodium uptake and membrane excitation in Paramecium. | Although the phenotypes of many membrane-excitation mutants of Paramecium are best expressed in Na+-containing solutions, little is known about the role of Na+ in membrane excitation in Paramecium. By measuring 22Na fluxes, we have shown that: (a) The total cellular Na+ content is equivalent to a cytoplasmic concentrat... | ['Animals', 'Cell Membrane', 'Cold Temperature', 'Cytoplasm', 'Electrophysiology', 'Movement', 'Mutation', 'Paramecium', 'Sodium'] | 468,909 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regulation of nerve growth factor and nerve growth factor receptor production by NMDA in C6 glioma cells. | The synthesis of nerve growth factor (NGF) and nerve growth factor receptor (NGFR) were studied in a C6 glioma cell line by Northern blot hybridization. In response to a glutamate agonist N-methyl-D-aspartic acid (NMDA), NGF mRNA increased by up to 2-fold after 4-12 h of culture. The non-NMDA receptor agonists, quisqua... | ['2-Amino-5-phosphonovalerate', 'Animals', 'Base Sequence', 'Blotting, Northern', 'Bucladesine', 'Cyclic AMP', 'Glioma', 'Kainic Acid', 'Molecular Sequence Data', 'N-Methylaspartate', 'Neoplasm Proteins', 'Nerve Growth Factors', 'Quisqualic Acid', 'RNA, Messenger', 'RNA, Neoplasm', 'Rats', 'Receptors, Cell Surface', 'R... | 1,353,854 | [['D12.125.070.950.100', 'D12.125.740.025'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D03.633.100.759.646.138.395.250', 'D13.695.462.200.250', 'D13.695.667.138.395.250', 'D13.695.827.068.395.250'], ['D03.633.100.759.646.138.395', 'D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ultrasonic diagnostic instruments. | The underlying physical principles and current limitations of diagnostic ultrasonic instruments are reviewed. Recently developed ultrasonic imaging devices using pulsed-reflected ultrasound are discussed in detail. These instruments transmit short trains of 1.5- to 10-megahertz sound. Echoes reflected from tissue are c... | ['Auscultation', 'Blood Flow Velocity', 'Echocardiography', 'Heart Valve Diseases', 'Humans', 'Rheology', 'Ultrasonics', 'Ultrasonography'] | 7,423,186 | [['E01.370.600.060'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C14.280.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.830', 'H01.671.808'], ['H01.671.031.849'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Wells' syndrome (eosinophilic cellulitis): correlation between clinical activity, eosinophil levels, eosinophil cation protein and interleukin-5. | Wells' syndrome (WS) (eosinophilic cellulitis) is characterized by the presence of oedematous skin lesions associated with eosinophilia of the tissues. It has recently been observed that in patients with this disease, increased eosinophil cation protein (ECP) and interleukin (IL) -5 can be detected in peripheral blood,... | ['Adult', 'Blood Proteins', 'Cellulitis', 'Eosinophil Granule Proteins', 'Eosinophilia', 'Eosinophils', 'Female', 'Humans', 'Interleukin-5', 'Leukocyte Count', 'Ribonucleases', 'Syndrome'] | 10,215,782 | [['M01.060.116'], ['D12.776.124'], ['C01.800.130', 'C01.830.200', 'C17.300.185', 'C23.550.470.756.200'], ['D12.776.124.486.379'], ['C15.378.553.231'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.202'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Marmoricola aquaticus sp. nov., an actinomycete isolated from a marine sponge. | A novel marine actinomycete, designated B374(T), was isolated from a marine sponge, Glodia corticostylifera, which was collected from S?o Paulo, Brasil. The taxonomic position of B374(T) was established by using data derived from a polyphasic approach. The organism showed a combination of chemotaxonomic and morphologic... | ['Actinomycetales', 'Animals', 'Base Composition', 'Brazil', 'DNA, Bacterial', 'Fatty Acids', 'Molecular Sequence Data', 'Nucleic Acid Hybridization', 'Phylogeny', 'Porifera', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA'] | 26,231,541 | [['B03.510.024.049'], ['B01.050'], ['G02.111.080'], ['Z01.107.757.176'], ['D13.444.308.212'], ['D10.251'], ['L01.453.245.667'], ['E05.393.661', 'G02.111.611'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.050.500.802'], ['D13.444.735.686.670'], ['E05.393.760.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Influence of the maternal birth status on offspring: a systematic review and meta-analysis. | BACKGROUND: Maternal low birth weight (LBW), preterm birth (PTB) and small-for-gestational age (SGA) birth status have been suggested as precursors for an infant being born LBW, PTB or SGA.OBJECTIVE: To systematically review the risks of infant LBW/PTB/SGA among mothers who were LBW/PTB/SGA.SEARCH STRATEGY: Medline, Em... | ['Female', 'Humans', 'Infant, Newborn', 'Infant, Small for Gestational Age', 'Mothers', 'Pregnancy', 'Premature Birth', 'Quantitative Trait, Heritable'] | 19,916,879 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.460.560'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['G08.686.784.769'], ['C13.703.420.491.500'], ['G05.420.720']] | ['Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
A porohyperelastic finite element model of the eye: the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics. | Progressively deteriorating visual field is a characteristic feature of primary open-angle glaucoma (POAG), and the biomechanics of optic nerve head (ONH) is believed to be important in its onset. We used porohyperelasticity to model the complex porous behavior of ocular tissues to better understand the effect variatio... | ['Biomechanical Phenomena', 'Finite Element Analysis', 'Glaucoma', 'Humans', 'Intraocular Pressure', 'Models, Theoretical', 'Optic Disk', 'Permeability', 'Sclera', 'Trabecular Meshwork'] | 26,195,024 | [['G01.154.090', 'G01.374.089'], ['E05.355'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['E05.599'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['G02.723'], ['A09.371.784'], ['A09.371.060.932']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Profiles of a healthful diet and its relationship to biomarkers in a population sample from Mediterranean southern France. | OBJECTIVES: The failure of single-nutrient supplementation to prevent disease in intervention studies underlines the necessity to develop a holistic view of food intake. The objectives of this study were to devise a diet quality index (DQI) and identify biomarkers of multidimensional dietary behavior.DESIGN: A nutritio... | ['Adult', 'Aged', 'Biomarkers', 'Cholesterol', 'Diet', 'Docosahexaenoic Acids', 'Eicosapentaenoic Acid', 'Erythrocytes', 'Female', 'France', 'Humans', 'Male', 'Middle Aged', 'Nutrition Surveys', 'Statistics, Nonparametric', 'Vitamin E', 'beta Carotene'] | 11,043,701 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G07.203.650.240'], ['D10.212.302.380.410.210', 'D10.251.355.337.250', 'D10.627.430.450.375'], ['D10.212.302.380.410.385', 'D10.251.355.255.200', 'D10.251.355.337.290', 'D10.627.430.450.390'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. | OBJECTIVE: Polymorphisms found in genes encoding adhesion molecules have been reported to be associated with atherosclerosis. We investigated the Ser128Arg polymorphism in the E-selectin gene in Japanese patients with myocardial infarction and its functional significance.METHODS AND RESULTS: Results from 135 patients w... | ['Adult', 'Aged', 'Amino Acid Substitution', 'Cell Adhesion', 'Cells, Cultured', 'Chemotaxis, Leukocyte', 'E-Selectin', 'Endothelial Cells', 'Endothelium, Vascular', 'Female', 'Gene Frequency', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Mitogen-Activated Protein Kinase 1', 'Mitogen-Activated Protein Kinase 3', 'Mitogen... | 12,649,084 | [['M01.060.116'], ['M01.060.116.100'], ['E05.393.420.601.035', 'G05.558.109'], ['G04.022'], ['A11.251'], ['G04.198.424.233'], ['D12.776.395.550.200.700.300', 'D12.776.503.843.300', 'D12.776.543.550.200.700.300', 'D23.050.301.350.700.300'], ['A11.436.275'], ['A07.015.700.500', 'A10.272.491.355'], ['G05.330'], ['B01.050.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 |
Seasonality, smoking and history of poor treatment compliance are strong predictors of dropout in a naturalistic 6 year follow-up of bipolar patients. | Bipolar disorder is a highly recurrent disease which requires long-term treatment. Dropout is a major problem, poorly understood. The objectives of this study were to know the risk of dropout of a cohort of bipolar patients under ambulatory treatment and to identify the clinical profile of patients more likely to aband... | ['Adult', 'Age Factors', 'Aged', 'Bipolar Disorder', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Patient Compliance', 'Patient Dropouts', 'Predictive Value of Tests', 'Retrospective Studies', 'Risk Factors', 'Seasons', 'Smoking', 'Time Factors'] | 24,986,371 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F03.084.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/Vincristine in Relapsed/Refractory Aggressive B-cell Lymphoma. | PURPOSE: The aurora A kinase inhibitor alisertib demonstrated single-agent clinical activity and preclinical synergy with vincristine/rituximab in B-cell non-Hodgkin lymphoma (B-NHL). This phase I study aimed to determine the safety and recommended phase II dose (RP2D) of alisertib in combination with rituximab ± vincr... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Aurora Kinase A', 'Azepines', 'Disease Progression', 'Drug Monitoring', 'Drug Resistance, Neoplasm', 'Female', 'Humans', 'Lymphoma, B-Cell', 'Male', 'Maximum Tolerated Dose', 'Middle Aged', 'Molecular Targeted Therapy', 'Neoplasm ... | 30,082,475 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D08.811.913.696.620.682.700.103.500', 'D12.776.167.049.500'], ['D03.383.066'], ['C23.550.291.656'], ['E01.370.520.200'], ['G07.690.773.984.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Microdermabrasion: a clinical, histometric, and histopathologic study. | BACKGROUND: Microdermabrasion is a nonchemical superficial resurfacing procedure that removes the stratum corneum. Because it is a somewhat subtle procedure, it may be difficult to demonstrate its cosmetic benefit.OBJECTIVES: To assess the efficacy of microdermabrasion in treatment of melasma, postacne scarring, striae... | ['Acne Vulgaris', 'Adolescent', 'Adult', 'Aged', 'Biopsy', 'Cicatrix', 'Dermabrasion', 'Dermis', 'Epidermis', 'Female', 'Humans', 'Male', 'Melanosis', 'Middle Aged', 'Skin Aging', 'Striae Distensae', 'Young Adult'] | 27,357,600 | [['C17.800.030.150', 'C17.800.794.111'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['E02.218.210', 'E04.6... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Intracellular Fas ligand in normal and malignant breast epithelium does not induce apoptosis in Fas-sensitive cells. | Fas ligand (FasL) is expressed on some cancers and may play a role in the immune evasion of the tumour. We used immuno-histochemistry to study the expression of Fas and FasL in tissue samples from breast cancer patients, as well as normal breast tissue. Our results show that Fas and FasL are co-expressed both in normal... | ['Animals', 'Apoptosis', 'Blotting, Western', 'Breast', 'Breast Neoplasms', 'Cells, Cultured', 'Epithelium', 'Fas Ligand Protein', 'Female', 'Flow Cytometry', 'Gene Expression Regulation', 'Humans', 'Immunohistochemistry', 'Jurkat Cells', 'Membrane Glycoproteins', 'RNA', 'Reverse Transcriptase Polymerase Chain Reaction... | 11,104,571 | [['B01.050'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['A11.251'], ['A10.272'], ['D12.644.276.374.750.249', 'D12.776.395.550.312', 'D12.776.467.374.750.249', 'D12.776.543.550.312', 'D23.529... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Preliminary experience and development of an algorithm for the optimal use of the laparoscopic component separation technique for myofascial advancement during ventral incisional hernia repair. | BACKGROUND: Component separation technique (CST) enables rectus abdominus medialization, but may cause wound complications. Few published outcomes exist involving laparoscopic CST. Our aim was to examine feasibility and outcomes involving open and laparoscopic (lap) CST during ventral incisional hernia repair (VIHR) an... | ['Abdominal Wall', 'Aged', 'Algorithms', 'Cohort Studies', 'Feasibility Studies', 'Female', 'Hernia, Ventral', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Retrospective Studies'] | 21,524,200 | [['A01.923.047.050'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['C23.300.707.374.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Mn2+ exerts stronger structural effects than the Mn-citrate complex on the human erythrocyte membrane and molecular models. | While traces of manganese (Mn) take part in important and essential functions in biology, elevated exposures have been shown to cause significant toxicity. Chronic exposure to the metal leads to manganese neurotoxicity (or manganism), a brain disorder that resembles Parkinsonism. Toxic effect mechanisms of Mn is not un... | ['Citrates', 'Dimyristoylphosphatidylcholine', 'Erythrocyte Membrane', 'Humans', 'Manganese', 'Microscopy, Electron, Scanning', 'Models, Molecular', 'Phosphatidylethanolamines', 'X-Ray Diffraction'] | 19,880,186 | [['D02.241.081.901.434'], ['D10.570.755.375.760.400.800.200'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.484', 'D01.268.956.374', 'D01.552.544.484'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E05.599.595'], ['D10.570.755.375.760... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Directed evolution of bicyclic peptides for therapeutic application. | Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin. The success of cyclic peptide therapeutics is based on their ability to bind with high affinity, their good target selectivity and th... | ['Directed Molecular Evolution', 'Half-Life', 'Peptides, Cyclic'] | 24,594,337 | [['E05.393.420.175'], ['G01.910.405'], ['D04.345.566', 'D12.644.641']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Does active referral by a doctor or 12-Step peer improve 12-Step meeting attendance? Results from a pilot randomised control trial. | BACKGROUND: Active engagement in 12-Step self-help groups (SHG) is associated with improvements in substance use outcomes during and after treatment, yet levels of participation in SHG meetings in the U.K. remain low.METHOD: An RCT investigating the impact of active referral to SHG, delivered by doctors or 12-Step peer... | ['Adult', 'Alcoholism', 'Benzodiazepines', 'Cocaine-Related Disorders', 'Demography', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Male', 'Middle Aged', 'Opioid-Related Disorders', 'Patient Acceptance of Health Care', 'Patient Compliance', 'Physicians', 'Pilot Projects', 'Psychiatric St... | 22,677,458 | [['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['D03.633.100.079.080'], ['C25.775.300', 'F03.900.300'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C25.775.643.500', 'F03.900.647.500'], ['F01.100.150.750.500', 'F0... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Amino acid pairs susceptible to variants in human protein C precursor. | In this study, we analyze the amino acid pairs in human protein C precursor to determine which amino acid pairs are more susceptible to 71 variants from missense mutant human protein C precursor. The results show 85.92% of 71 variants occur at randomly unpredictable amino acid pairs accounting for 61.96% of amino acid ... | ['Amino Acid Substitution', 'Forecasting', 'Genetic Variation', 'Humans', 'Mutation, Missense', 'Protein C', 'Protein Precursors', 'Thrombophilia'] | 16,029,164 | [['E05.393.420.601.035', 'G05.558.109'], ['I01.320'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590.650'], ['D08.622.705', 'D12.776.124.650', 'D12.776.395.635', 'D12.776.811.243.705', 'D23.113.700'], ['D12.776.811'], ['C15.378.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Angiotensin II influences ovarian follicle development in the transgenic (mRen-2)27 and Sprague-Dawley rat. | There is accumulating evidence that local renin-angiotensin systems (RASs) influence cell growth and organ function in a variety of tissues including the ovary. The first aim of this study was to characterise the cellular location of RAS components in the rat ovary. This was facilitated by the use of the hypertensive t... | ['Angiotensin II', 'Animals', 'Animals, Genetically Modified', 'Female', 'Hypertension', 'Immunohistochemistry', 'In Situ Hybridization', 'Litter Size', 'Ovarian Follicle', 'Peptidyl-Dipeptidase A', 'Pregnancy', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, Angiotensin, Type 1', 'Renin'] | 14,765,984 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['C14.907.489'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Genome sequence of Enterococcus hirae (Streptococcus faecalis) ATCC 9790, a model organism for the study of ion transport, bioenergetics, and copper homeostasis. | Enterococcus hirae ATCC 9790 is a Gram-positive lactic acid bacterium that has been used in basic research for over 4 decades. Here we report the sequence and annotation of the 2.8-Mb genome of E. hirae and its endemic 29-kb plasmid pTG9790. | ['Copper', 'DNA, Bacterial', 'Energy Metabolism', 'Enterococcus faecalis', 'Genome, Bacterial', 'Homeostasis', 'Ion Transport', 'Molecular Sequence Data', 'Plasmids', 'Sequence Analysis, DNA'] | 22,933,757 | [['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D13.444.308.212'], ['G03.295'], ['B03.353.750.250.250.280', 'B03.510.550.250.250.280'], ['G05.360.340.358.207'], ['G07.410'], ['G03.143.500'], ['L01.453.245.667'], ['G05.360.600'], ['E05.393.760.700']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Construction of multiform scFv antibodies using linker peptide. | Multiform single chain variable fragments (scFvs) including different length linker scFvs and bispecific scFv were constructed. The linker lengths of 0, 3, 5, 8, 12, and 15 amino acids between V(H) and V(L) of antideoxynivalenol (anti-DON) scFv were used to analyze the affinities of scFvs. The affinity constants of the... | ['Antibodies', 'Antibodies, Bispecific', 'Antibody Affinity', 'Base Sequence', 'Cloning, Molecular', 'Enzyme-Linked Immunosorbent Assay', 'Escherichia coli', 'Food Contamination', 'Gene Expression', 'Immunoglobulin Variable Region', 'Peptides', 'Trichothecenes', 'Triticum', 'Zearalenone'] | 18,499,076 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D12.776.124.486.485.114.125', 'D12.776.124.790.651.114.134', 'D12.776.377.715.548.114.134'], ['G12.040', 'G12.122.125'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['E05.478.566.350.170', 'E05.478.566.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Responder characteristics to a single oral dose of cholinesterase inhibitor: a double-blind placebo-controlled study with tacrine in Alzheimer patients. | A proportion of Alzheimer's disease (AD) patients treated for several months with cholinesterase (ChE) inhibitors have shown some favorable response on cognition, but the characteristics of the responders are still unclear. This study attempts to identify the characteristics of individuals with a positive behavioral re... | ['Acetylcholine', 'Administration, Oral', 'Aged', 'Alleles', 'Alzheimer Disease', 'Apolipoprotein E4', 'Apolipoproteins E', 'Attention', 'Brain', 'Cholinesterase Inhibitors', 'Cognition', 'Cross-Over Studies', 'Double-Blind Method', 'Electroencephalography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neuropsychologica... | 11,125,238 | [['D02.092.211.111'], ['E02.319.267.100'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D10.532.091.500.750', 'D12.776.070.400.500.750', 'D12.776.521.120.500.750'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['F02.830.104.214'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dissemination and implementation: INQRI's potential impact. | BACKGROUND: Application of research evidence in care delivery improves patient outcomes. Large gaps still exist, however, between recommended care and that used in practice. To increase the understanding of implementation studies, and dissemination of research findings, we present the perspective of investigators from ... | ['Accidental Falls', 'Assisted Living Facilities', 'Evidence-Based Practice', 'Foundations', 'Geriatric Nursing', 'Humans', 'Motor Activity', "Nurse's Role", 'Nursing Evaluation Research', 'Organizational Case Studies', 'Outcome and Process Assessment, Health Care', 'Patient-Centered Care', 'Personnel Staffing and Sche... | 23,502,916 | [['N06.850.135.122'], ['J03.775.187', 'N02.278.825.187'], ['H02.249'], ['N03.219.483.311', 'N03.540.630.180'], ['H02.478.676.236', 'N02.421.533.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['F01.829.316.616.625.450', 'N05.300.100.337'], ['H01.770.644.145.390.432', 'H02.478... | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
Safety of local anaesthesia in dental patients taking oral anticoagulants: is it still controversial? | The aim of this study was to investigate the safety of local infiltration techniques and the inferior alveolar nerve block (IANB) in dental patients taking oral anticoagulants. A total of 352 patients were given a total of 560 injections of local anaesthetic (119 IANB and 441 others). The study group comprised 279 pati... | ['Administration, Oral', 'Adult', 'Aged', 'Aged, 80 and over', 'Anesthesia, Dental', 'Anesthesia, Local', 'Anesthetics, Local', 'Anticoagulants', 'Female', 'Follow-Up Studies', 'Hematoma', 'Hemorrhage', 'Humans', 'International Normalized Ratio', 'Lidocaine', 'Longitudinal Studies', 'Male', 'Mandibular Nerve', 'Maxilla... | 21,130,546 | [['E02.319.267.100'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E03.155.141', 'E06.045'], ['E03.155.086.231'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['D27.505.954.502.119'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.45... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expression of Glut-1 is a prognostic marker for oral squamous cell carcinoma patients. | Oral squamous cell carcinoma (OSCC) is among the tenth most common human cancers worldwide with evidence of an increase in incidence rate and mortality. Despite advances in treatment modalities, the prognosis of this cancer is still very poor and has not changed over the past two decades. This study is based on samples... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Female', 'Gene Expression Regulation, Neoplastic', 'Glucose Transporter Type 1', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Mouth Neoplasms', 'Prognosis', 'Proportional Hazards Models', 'Retrospective Studies'] | 19,020,718 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['G05.308.370'], ['D12.776.157.530.500.500.500', 'D12.776.157.530.937.563.500', 'D12.776.543.585.500.500.500', 'D12.776.543.585.937.625.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.50... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Micro-RNA quantification using DNA polymerase and pyrophosphate quantification. | A rapid quantification method for micro-RNA based on DNA polymerase activity and pyrophosphate quantification has been developed. The tested micro-RNA serves as the primer, unlike the DNA primer in all DNA sequencing methods, and the DNA probe serves as the template for DNA replication. After the DNA synthesis, the pyr... | ['Base Sequence', 'Biochemistry', 'Biological Assay', 'Cell Line, Tumor', 'Chemical Fractionation', 'DNA-Directed DNA Polymerase', 'Diphosphates', 'Humans', 'Limit of Detection', 'MicroRNAs', 'Molecular Sequence Data', 'Reference Standards'] | 21,910,961 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['H01.158.201', 'H01.181.122'], ['E05.091'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.196.155'], ['D08.811.913.696.445.308.300'], ['D01.029.260.700.675.374.775.150', 'D01.248.497.158.730.650.200', 'D01.695.625.675.650.775.150'], ['B01.050.150.900.649.313.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Views on death and dying among health care workers in an Indian cancer care hospice: balancing individual and collective perspectives. | In providing palliative and end-of-life care, professional and lay hospice workers alike attend to patient and family needs to encourage a dignified death. However, there are few comparative inquiries documenting how differential workplace preparation affects the processes and outcomes related to being confronted to de... | ['Adaptation, Psychological', 'Adolescent', 'Attitude to Death', 'Culture', 'Evaluation Studies as Topic', 'Female', 'Health Personnel', 'Humans', 'India', 'Interviews as Topic', 'Male', 'Professional-Patient Relations', 'Social Class', 'Social Values', 'Spirituality', 'Stress, Psychological', 'Terminal Care', 'Young A... | 21,464,118 | [['F01.058'], ['M01.060.057'], ['F01.100.125', 'N05.300.125'], ['I01.076.201.450', 'I01.880.853.100'], ['E05.337', 'N05.715.360.335'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], [... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Insulin sensitizing actions of fenugreek seed polyphenols, quercetin & metformin in a rat model. | BACKGROUND & OBJECTIVE: Plant polyphenols have been known to exert anti-diabetic action and promote insulin action. The present study was carried out to compare the effects of administration of fenugreek seed polyphenolic extract (FPEt), quercetin and metformin (a positive control) in an acquired model of insulin resis... | ['Animals', 'Blood Glucose', 'Fatty Acids, Nonesterified', 'Flavonoids', 'Fructose', 'Glucose Tolerance Test', 'Insulin', 'Insulin Resistance', 'Liver', 'Male', 'Metformin', 'Phenols', 'Plant Extracts', 'Polyphenols', 'Protein Tyrosine Phosphatases', 'Protein-Tyrosine Kinases', 'Quercetin', 'Rats', 'Rats, Wistar', 'See... | 19,535,835 | [['B01.050'], ['D09.947.875.359.448.500'], ['D10.251.310'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D09.947.875.359.250', 'D09.947.875.465.354'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.452.394.968.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Locally advanced prostatic cancer and systemic involvement]. | In a group of 115 patients with prostatic cancer, the correlation between the local and systemic evolution of the neoplasm has been evaluated. In 80 patients non local and systemic up-staging of the tumor was observed. In further 18 patients both local and systemic staging uppers and in the remaining 17 patients no cor... | ['Follow-Up Studies', 'Humans', 'Male', 'Neoplasm Metastasis', 'Neoplasm Staging', 'Prostatic Neoplasms'] | 7,889,057 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650', 'C23.550.727.650'], ['E01.789.625'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension. | The case is presented of a hypertensive patient on reserpine, who developed ventricular irritability after administration of alfentanil, a new ultra-short-acting narcotic used in anesthesia. The dysrhythmias resolved after cessation of the offending agent. There are no reported cases of interaction of reserpine and alf... | ['Alfentanil', 'Anesthesia, Intravenous', 'Arrhythmias, Cardiac', 'Bradycardia', 'Cardiac Complexes, Premature', 'Drug Interactions', 'Female', 'Humans', 'Hypertension', 'Middle Aged', 'Reserpine', 'Tachycardia', 'Ventricular Function'] | 1,722,376 | [['D03.383.621.265.100'], ['E03.155.308'], ['C14.280.067', 'C23.550.073'], ['C14.280.067.319', 'C23.550.073.300'], ['C14.280.067.325', 'C14.280.123.375', 'C23.550.073.325'], ['G07.690.773.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['D03.132.436.681.933.500', 'D03.633.1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Increasing health insurance coverage in the first year of life. | OBJECTIVES: To determine the proportion of infants who are uninsured and the sociodemographic characteristics of their mothers, including prenatal and post-partum insurance coverage, in order to identify strategies to increase infant health coverage.METHODS: Data from the 2001 California Maternal and Infant Health Asse... | ['Adolescent', 'Adult', 'California', 'Cross-Sectional Studies', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Insurance Coverage', 'Insurance, Health', 'Medicaid', 'Poverty'] | 16,328,706 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['N03.219.521.576.265'], ['N03.219.521.576.343'], ['N03.219.521... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Closure of the laryngeal vestibule during deglutition. | With the aid of high-speed cineradiography (up to 100 frames per second) the closure of the laryngeal vestibule during deglutition was studied in 150 volunteers free from swallowing complaints. The closure was observed to be effected by a peristaltic-like wave from below. This was accomplished in two steps. First the c... | ['Adult', 'Aged', 'Cineradiography', 'Deglutition', 'Female', 'Humans', 'Laryngeal Muscles', 'Larynx', 'Male', 'Middle Aged', 'Muscles', 'Pharynx'] | 7,064,688 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.350.700.225.469'], ['G10.261.178'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567.500', 'A04.329.604'], ['A04.329'], ['M01.060.116.630'], ['A02.633', 'A10.690'], ['A03.556.750', 'A04.623', 'A14.724']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genetic factors influencing prostate cancer risk in Norwegian men. | Norway has one of the highest rates of death due to prostate cancer (PCa) in the world. To assess the contribution of both common and rare single nucleotide variants (SNPs) to the prostate cancer burden in Norway, we assessed the frequency of the established prostate cancer susceptibility allele, HOXB13 G84E, as well a... | ['Adult', 'Aged', 'Alleles', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Genotype', 'Germ-Line Mutation', 'Homeodomain Proteins', 'Humans', 'Male', 'Middle Aged', 'Norway', 'Polymorphism, Single Nucleotide', 'Prostate', 'Prostatic Neoplasms'] | 29,181,843 | [['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['G05.365.590.350'], ['D12.776.260.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.816.374'], ['G05.365.795.598'], ['A05.360.444.575', 'A10.336.707... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
The tropics: cradle, museum or casino? A dynamic null model for latitudinal gradients of species diversity. | Several ecological and evolutionary hypotheses have been proposed to explain the latitudinal diversity gradient (LDG), but a general model for this conspicuous pattern remains elusive. Mid-domain effect (MDE) models generate gradients of species diversity by randomly placing the geographic ranges of species in one- or ... | ['Biodiversity', 'Extinction, Biological', 'Geography', 'Models, Biological', 'Tropical Climate'] | 18,445,032 | [['G16.500.275.157.049', 'N06.230.124.049'], ['G16.510'], ['H01.277.500'], ['E05.599.395'], ['G16.500.275.071.600', 'N06.230.300.100.250.600']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Diabetes mellitus reduces the antiarrhythmic effect of ion channel blockers. | We designed the present study to examine whether diabetes mellitus affects the antiarrhythmic effect of flecainide, a sodium channel blocker, E-4031, a potassium channel blocker, and verapamil, a calcium channel blocker, in diabetic rats. The experiments were performed in intact and diabetic rats 2, 4, and 6 wk after a... | ['Animals', 'Anti-Arrhythmia Agents', 'Arrhythmias, Cardiac', 'Blood Pressure', 'Diabetes Mellitus', 'Diabetes Mellitus, Experimental', 'Epinephrine', 'Flecainide', 'Halothane', 'Ion Channels', 'Male', 'Piperidines', 'Potassium Channel Blockers', 'Pyridines', 'Rats', 'Rats, Sprague-Dawley', 'Sodium Channel Blockers', '... | 16,931,659 | [['B01.050'], ['D27.505.954.411.097'], ['C14.280.067', 'C23.550.073'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C18.452.394.750', 'C19.246'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optimization of matrix assisted desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) for the characterization of Bacillus and Brevibacillus species. | Over the past few decades there has been an increased interest in using various analytical techniques for detecting and identifying microorganisms. More recently there has been an explosion in the application of matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS) for bacterial ch... | ['Bacillus', 'Brevibacillus', 'Species Specificity', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 25,086,893 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['B03.300.390.400.160', 'B03.353.500.117', 'B03.510.100.117', 'B03.510.415.400.179', 'B03.510.460.410.165'], ['G16.824'], ['E05.196.566.755']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mass spectrometry imaging of small molecules using matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS). | Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) uses inorganic particles or porous surfaces as the energy-mediating means to promote desorption and ionization of low-mass analytes of interest. With good stability during laser ablation, SALDI substrates exhibit reduced background in the low-mas... | ['Animals', 'Brain', 'Cerebellum', 'Cerebrum', 'Diagnostic Imaging', 'Mass Spectrometry', 'Mice', 'Microscopy'] | 20,680,595 | [['B01.050'], ['A08.186.211'], ['A08.186.211.132.810.428.200'], ['A08.186.211.200.885.287'], ['E01.370.350'], ['E05.196.566'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A prevalence survey of mental disorders among children in a rural Malaysian village. | This is the first epidemiological survey of mental disorders among children in a Malaysian village. The WHO Research Questionnaire for Children (RQC) was used for initial screening followed by a semistructured interview, the Follow-up Interview for Children (FIC) at its second stage. Diagnosis was obtained by using Rut... | ['Adolescent', 'Age Factors', 'Child', 'Child, Preschool', 'Cross-Sectional Studies', 'Developing Countries', 'Female', 'Humans', 'Incidence', 'Infant', 'Malaysia', 'Male', 'Mass Screening', 'Mental Disorders', 'Risk Factors', 'Rural Population', 'Sex Factors'] | 8,488,745 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.615.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Gonadotropin-releasing hormone induces classical meiotic maturation in subpopulations of atretic preantral follicles. | GnRH has been shown to induce premature meiotic maturation in preantral follicles of the immature estrogen-primed hypophysectomized rat. As these animals are free of circulating gonadotropins and contain large numbers of full-grown oocytes in preantral follicles, we have investigated this model to determine its usefuln... | ['Animals', 'Diethylstilbestrol', 'Dose-Response Relationship, Drug', 'Female', 'Follicular Atresia', 'Gonadotropin-Releasing Hormone', 'Meiosis', 'Ovarian Follicle', 'Rats', 'Rats, Inbred Strains', 'Time Factors', 'Triptorelin Pamoate'] | 3,896,759 | [['B01.050'], ['D02.455.426.559.389.150.700.725.500'], ['G07.690.773.875', 'G07.690.936.500'], ['G08.686.290'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['G04.144.220.220.687', 'G05.113.220.687'], ['A05.360.319.114.630.535', 'A0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relative salience of syllable structure and syllable order in zebra finch song. | There is a rich history of behavioral and neurobiological research focused on the 'syntax' of birdsong as a model for human language and complex auditory perception. Zebra finches are one of the most widely studied songbird species in this area of investigation. As they produce song syllables in a fixed sequence, it is... | ['Animals', 'Auditory Perception', 'Female', 'Finches', 'Male', 'Species Specificity', 'Vocalization, Animal'] | 29,766,379 | [['B01.050'], ['F02.463.593.071', 'G07.888.125'], ['B01.050.150.900.248.620.750.250'], ['G16.824'], ['F01.145.113.055.800']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacokinetic properties and in-vivo biological activity of recombinant human erythropoietin encapsulated in red blood cells. | The in-vivo survival of 51Cr-labelled murine red blood cells (RBCs) loaded with recombinant human erythropoietin (rhEpo-RBCs) was slightly lower than that of normal RBCs. Intravenous administration to normal mice of the encapsulated rhEpo shows the pharmacokinetic bicompartmental profile typical of the free rhEpo. Dist... | ['Animals', 'Cell Division', 'Disease Models, Animal', 'Drug Carriers', 'Drug Delivery Systems', 'Erythrocyte Aging', 'Erythrocytes', 'Erythropoietin', 'Humans', 'Mice', 'Mice, Inbred Strains', 'Polycythemia', 'Recombinant Proteins'] | 9,067,098 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D26.255.260', 'E02.319.300.380'], ['E02.319.300'], ['G04.043.260', 'G09.188.230'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D12.644.276.374.410.240.150', 'D12.776.395.240.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hereditary agenesis of ten maxillary posterior teeth: a family history. | A family is described, where the mother and her two sons had similar bilateral congenital absences of the following maxillary teeth: the second premolars, the first, second and possibly the third molars, as well as, in the sons, the second primary molars. The size, shape and formation of the remaining teeth were within... | ['Adult', 'Anodontia', 'Bicuspid', 'Child', 'Female', 'Humans', 'Male', 'Maxilla', 'Molar', 'Tooth, Deciduous'] | 3,857,243 | [['M01.060.116'], ['C07.650.800.100', 'C07.793.700.100', 'C16.131.850.800.100'], ['A14.549.167.860.150'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.645', 'A14.521.645'], ['A14.549.167.860.525'], ['A14.549.167.860.700']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
REM sleep deprivation and food intake. | The effect of REM-sleep deprivation (REM-SD) on diet preference was studied in rats. REM-SD for a period of 72 hrs produced an increase in day, night and 24 hrs (day plus night) intakes of Carbohydrate Rich diet (CRD) and Total diet (TD). Body weight (BWt) was also increased. The maximum increase in the above parameter... | ['Animals', 'Body Temperature', 'Body Weight', 'Diet', 'Dietary Carbohydrates', 'Dietary Proteins', 'Eating', 'Male', 'Rats', 'Sleep Deprivation', 'Sleep, REM'] | 2,592,037 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.203.650.240'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.650.283', 'G10.261.330']... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of zinc sulphate on gelling properties of phosphorylated protein isolate from yellow stripe trevally. | Impacts of zinc sulphate (ZnSO4) (0-140 ìmol/kg) on gel properties of yellow stripe trevally surimi added with sodium tripolyphosphate (STPP) (0.25% and 0.5%, w/w) and protein isolate phosphorylated with STPP at 0.25% and 0.5% (w/w) were studied. Gels from surimi added with 60 ìmol ZnSO4/kg in the absence and presence ... | ['Animals', 'Fish Products', 'Fish Proteins', 'Food Handling', 'Gels', 'Perciformes', 'Phosphorylation', 'Polyphosphates', 'Zinc Sulfate'] | 23,871,033 | [['B01.050'], ['G07.203.300.600.875.400', 'J02.500.600.875.400'], ['D12.776.325'], ['J01.576.423.200'], ['D20.280.320', 'D26.255.165.320'], ['B01.050.150.900.493.602'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D01.029.260.700.675.374.775', 'D01.248.497.158.730.650', 'D01.695.625.675.650.775'], ['D01.875.800.800.850... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Preoperative computed tomography-guided localization of ground-glass opacities with metallic clip. | Intraoperative localization of ground-glass opacities is difficult because they are not easy to palpate and may be invisible at radioscopy. Therefore, various techniques have been developed to improve intraoperative localization of these lesions, allowing an adequate surgical resection. The aim of this study is to repo... | ['Adenocarcinoma', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Diagnosis, Differential', 'Female', 'Humans', 'Image-Guided Biopsy', 'Lung Neoplasms', 'Middle Aged', 'Pneumonectomy', 'Preoperative Care', 'Risk Assessment', 'Sampling Studies', 'Solitary Pulmonary Nodule', 'Surgical Instruments', 'Thoracic ... | 23,992,711 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.384.100.370', 'E01.370.225.998.054.370', 'E01.370.388.100.370', 'E04.074.370', 'E05.200.500.384.100.370', 'E05.200.998.054.370', 'E05.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
New Bacterial Phytase through Metagenomic Prospection. | Alkaline phytases from uncultured microorganisms, which hydrolyze phytate to less phosphorylated myo-inositols and inorganic phosphate, have great potential as additives in agricultural industry. The development of metagenomics has stemmed from the ineluctable evidence that as-yet-uncultured microorganisms represent th... | ['6-Phytase', 'Amino Acid Sequence', 'Bacteria', 'Environment', 'Enzyme Stability', 'Gene Library', 'Genes, Bacterial', 'Hydrogen-Ion Concentration', 'Ions', 'Metagenomics', 'Metals', 'Models, Molecular', 'Phylogeny', 'Recombinant Proteins', 'Sequence Analysis, DNA', 'Structural Homology, Protein', 'Substrate Specifici... | 29,462,992 | [['D08.811.277.352.650.700'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B03'], ['G16.500.275', 'N06.230'], ['E05.916.360', 'G02.111.700.500'], ['G05.360.325'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G02.300'], ['D01.248.497'], ['H01.158.273.343.350.261'], ['D01.552'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability, and cell type of origin. | The sensitivity of 10 mouse lymphoid or myeloid cell lines to gamma-ray- and DNA-associated 125I-decay-induced clonogenic cell killing have been compared with their rate of loss of viability (membrane integrity) and with their putative cell type of origin. The pseudodiploid haematopoietic cell lines showed D0 values fo... | ['Animals', 'Bone Marrow', 'Cell Survival', 'DNA Damage', 'Gamma Rays', 'Gene Rearrangement, T-Lymphocyte', 'Immunophenotyping', 'Lymphocytes', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred DBA', 'Receptors, Antigen, T-Cell, alpha-beta'] | 7,907,118 | [['B01.050'], ['A15.382.216'], ['G04.346'], ['G05.200'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['G05.344.801', 'G12.500.287'], ['E01.370.225.812.447', 'E05.200.812.447', 'E05.478.594.450'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['B01.050.150.900.649.313.992.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytostatic and cytotoxic properties of the marine product bistratene A and analysis of the role of protein kinase C in its mode of action. | Bistratene A is a polyether which was isolated from the marine ascidian Lissoclinum bistratum Sluiter. The hypothesis has been tested that the cytostatic effect of bistratene A is mediated by modulation of protein kinase C (PKC). Human-derived A549 lung and MCF-7 breast adenocarcinoma cells are extremely sensitive to g... | ['Acetamides', 'Cell Division', 'Cell Line', 'Cytosol', 'Enzyme Activation', 'Ethers, Cyclic', 'Humans', 'Marine Toxins', 'Protein Kinase C', 'Pyrans', 'Signal Transduction', 'Spiro Compounds', 'Structure-Activity Relationship', 'Tetradecanoylphorbol Acetate', 'Tumor Cells, Cultured'] | 8,494,533 | [['D02.065.064', 'D02.241.081.018.110'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['G02.111.263', 'G03.328'], ['D02.355.291', 'D04.345.241'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.94... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
NF-êB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 | BACKGROUND: PM2.5 (particulate matter ? 2.5 ìm) is one of the leading environmental risk factors for the global burden of disease. Whereas increasing evidence has linked the adverse roles of PM2.5 with cardiovascular and respiratory diseases, limited but growing emerging evidence suggests that PM2.5 exposure can affect... | ['Air Pollutants', 'Animals', 'Cognitive Dysfunction', 'Gene Expression Regulation', 'Hippocampus', 'Inhalation Exposure', 'Maze Learning', 'Mice, Inbred C57BL', 'MicroRNAs', 'NF-kappa B', 'Particle Size', 'Particulate Matter', 'Spatial Memory', 'Synaptic Potentials'] | 28,851,397 | [['D27.888.284.101'], ['B01.050'], ['F03.615.250.700'], ['G05.308'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['N06.850.460.350.112'], ['F02.463.425.874.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Unchanged unilateral hearing loss and ipsilateral growth of an acoustic neuroma from 1 to 4 cm. | Progressive sensorineural hearing loss is the most important early symptom of a cerebellopontine angle process. A case report is presented of a 42-year-old woman who was referred to our department in 1979. Oil cisternography showed non filling of the left internal acoustic canal. Audiometry was planned as the method of... | ['Adult', 'Audiometry, Pure-Tone', 'Audiometry, Speech', 'Cerebellopontine Angle', 'Female', 'Follow-Up Studies', 'Hearing Loss, Sensorineural', 'Humans', 'Neuroma, Acoustic', 'Tomography, X-Ray Computed'] | 8,509,702 | [['M01.060.116'], ['E01.370.382.375.060.055'], ['E01.370.382.375.060.060'], ['A08.186.211.132.810.428.200.462'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target. | BACKGROUND: Locoregional recurrence and distant metastases are ominous events in patients with advanced oral squamous cell carcinoma (OSCC). The objective of this study was to identify functional biomarkers that are predictive of OSCC progression to metastasis.METHODS: The expression profile of a network of epithelial-... | ['Animals', 'Carcinoma, Squamous Cell', 'Cells, Cultured', 'Epithelial-Mesenchymal Transition', 'Female', 'Gene Expression Profiling', 'Humans', 'Male', 'Mice', 'Mouth Neoplasms', 'Nuclear Proteins', 'Prognosis', 'Twist-Related Protein 1'] | 24,150,986 | [['B01.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251'], ['G04.356.500'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['C04.588.443.591', 'C07.465.530'], ['D12.776.660'], ['E01.789'], ['D12.776.260.103.906.250', 'D12.776.930.125.906.25... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunocytological studies of Epstein-Barr viral antigen and antibody in rheumatoid synovial fluids. | Evidence for intra-articular immunity to Epstein-Barr virus (EBV) was sought in synovial fluids (SF) and SF phagocytes derived from patients with and without rheumatoid arthritis (RA). Antibody titres to EBV were not significantly different in SF of 32 RA and 25 non-RA patients. Whereas the majority of RA patients (69%... | ['Antibodies, Viral', 'Antigens, Viral', 'Arthritis, Rheumatoid', 'Complement C3', 'Female', 'Herpesvirus 4, Human', 'Humans', 'Immunoglobulins', 'Male', 'Phagocytes', 'Synovial Fluid'] | 6,310,723 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D23.050.327'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D12.776.124.050.140', 'D12.776.124.486.274.250'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. | Diabetes mellitus is a multifactorial metabolic disease, caused by the complete or relative absence of insulin hormone, which results in the deterioration of carbohydrate, protein, and lipid metabolism. The PON1 55 and 192 polymorphisms have been reported to be associated with type 2 diabetes and its complications. In ... | ['Amino Acid Substitution', 'Aryldialkylphosphatase', 'Body Mass Index', 'Case-Control Studies', 'Coronary Artery Disease', 'Diabetes Mellitus, Type 2', 'Diabetic Angiopathies', 'Gene Frequency', 'Genetic Association Studies', 'Genetics, Population', 'Genotype', 'Humans', 'Middle Aged', 'Phenotype', 'Polymorphism, Gene... | 20,820,904 | [['E05.393.420.601.035', 'G05.558.109'], ['D08.811.277.352.660.500'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C18.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
[Comparative in vitro research on 2 new antacid combinations--Ulsan and Ulsan D]. | Two new antacid combinations--Ulsan and Ulsan D with high acid-neutralizing properties, produced by original Bulgarian techniques are presented. They exceed in acid-binding and acid-reducing properties the drugs now in use: Antiacid, Neutracid, Almagel, Alcid V, Maaloxan, Gelusil-Lac. | ['Aluminum', 'Antacids', 'Buffers', 'Drug Combinations', 'Drug Evaluation, Preclinical', 'Drug Interactions', 'Gastric Acid', 'Hydrogen-Ion Concentration', 'In Vitro Techniques', 'Magnesium', 'Plant Extracts', 'Tablets'] | 3,433,734 | [['D01.268.557.050', 'D01.552.547.050'], ['D27.505.519.170', 'D27.505.954.483.080'], ['D27.720.470.280'], ['D26.310'], ['E05.290.750', 'E05.337.550'], ['G07.690.773.968'], ['A12.200.307.603'], ['G02.300'], ['E05.481'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D20.215.784.500', 'D26.667'], ['D26.255.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Potential differences in kidney allograft outcomes between ethnicities when converting to sirolimus base immunosuppression. | OBJECTIVE: The aim of this study was to determine whether ethnicity impacts graft outcomes in kidney transplant patients converted to sirolimus (SRL) and maintained on either calcineurin inhibitors (CI) or mycophenolate mofetil (MMF) with steroids.METHODS: This study analyzed kidney transplants converted to SRL and tra... | ['Adolescent', 'Adult', 'African Continental Ancestry Group', 'Continental Population Groups', 'Drug Therapy, Combination', 'Ethnic Groups', 'European Continental Ancestry Group', 'Female', 'Graft Rejection', 'Graft Survival', 'Half-Life', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Living Donors',... | 20,005,354 | [['M01.060.057'], ['M01.060.116'], ['M01.686.508.100'], ['M01.686.508'], ['E02.319.310'], ['M01.686.754', 'N01.224.317'], ['M01.686.508.400'], ['G12.875.545.328'], ['G12.875.545.340'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.870.500', 'E04.936.450.485', 'E04.950.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel "reactomics" approach for cancer diagnostics. | Non-invasive detection and monitoring of lethal diseases, such as cancer, are considered as effective factors in treatment and survival. We describe a new disease diagnostic approach, denoted "reactomics", based upon reactions between blood sera and an array of vesicles comprising different lipids and polydiacetylene (... | ['Humans', 'Neoplasms', 'Spectrometry, Fluorescence'] | 22,778,601 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methionine kinetics in adult men: effects of dietary betaine on L-[2H3-methyl-1-13C]methionine. | The effects of a daily 3-g supplement of betaine on kinetic aspects of L-[2H3-methyl-1-13C]methionine (MET) metabolism in healthy young adult men were explored. Four groups of four subjects each were given a control diet, based on an L-amino acid mixture supplying 29.5 and 21.9 mg.kg-1.d-1 of L-methionine and L-cystine... | ['Adult', 'Betaine', 'Carbon Isotopes', 'Cystine', 'Deuterium', 'Diet', 'Humans', 'Kinetics', 'Male', 'Methionine', 'Methylation', 'Nutritional Requirements'] | 1,858,702 | [['M01.060.116'], ['D02.092.877.883.077', 'D02.675.276.125'], ['D01.268.150.075', 'D01.496.123'], ['D01.248.497.158.874.390.369', 'D01.875.350.850.150.369', 'D02.886.030.230.369', 'D02.886.520.150.087', 'D12.125.095.369', 'D12.125.119.369', 'D12.125.166.230.369'], ['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Whole-Genome Sequencing in Microbial Forensic Analysis of Gamma-Irradiated Microbial Materials. | Effective microbial forensic analysis of materials used in a potential biological attack requires robust methods of morphological and genetic characterization of the attack materials in order to enable the attribution of the materials to potential sources and to exclude other potential sources. The genetic homogeneity ... | ['Bacteria', 'Biological Warfare Agents', 'Forensic Sciences', 'Gamma Rays', 'Genome, Bacterial', 'Sequence Analysis, DNA'] | 26,567,301 | [['B03'], ['D20.215.226', 'J01.637.870.900.100'], ['I01.198.780'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['G05.360.340.358.207'], ['E05.393.760.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
Ultrafine Fe3 | A pyrolytic method is described for preparation of ultrafine Fe3C nanoparticles incorporated into N-doped graphitic carbon nanosheets (Fe3C@NGCSs). Iron phthalocyanine and graphitic carbon nitride (g-C3N4) are used as starting materials. The hybrid nanocomposite was placed on a glassy carbon electrode (GCE) and then ap... | ['Ascorbic Acid', 'Biosensing Techniques', 'Carbon', 'Carbon Compounds, Inorganic', 'Dopamine', 'Electrochemical Techniques', 'Electrodes', 'Humans', 'Iron Compounds', 'Nanoparticles', 'Particle Size', 'Surface Properties', 'Uric Acid', 'Xanthine'] | 31,471,825 | [['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['E05.601.043'], ['D01.268.150'], ['D01.200'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E05.301'], ['E07.305.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.490'], ['J01.637.512.600'], ['G02.712'], ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Increased transglutaminase activity was associated with IL-6 release in cultured human gingival fibroblasts exposed to dental cast alloys. | Molecular mechanisms underlying gingival and periodontal inflammation caused by dental alloys are still poorly understood. Recently, it has been demonstrated that tissue transglutaminase can be involved in inflammatory cell response. The aim of this study was to evaluate effects of exposure to orthodontic materials on ... | ['Cell Line', 'Dental Alloys', 'Enzyme Activation', 'Fibroblasts', 'Gene Expression Regulation, Enzymologic', 'Gingiva', 'Gingivitis', 'Humans', 'Interleukin-6', 'Transglutaminases', 'Up-Regulation'] | 16,583,305 | [['A11.251.210'], ['D25.339.208', 'J01.637.051.339.208'], ['G02.111.263', 'G03.328'], ['A11.329.228'], ['G05.308.320'], ['A14.549.167.646.480'], ['C01.408', 'C07.465.714.258.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], ['D08.811.9... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effects of NO-donors, SIN-1 and GEA 3175 on prostacyclin and cGMP synthesis in cultured rat endothelial cells. | The aim of the present study was to investigate, whether nitric oxide (NO) modifies prostacyclin synthesis in endothelial cells. Two different NO-donors: SIN-1 (3-morpholino sydnonimine) and GEA 3175 (4-aryl-substituted oxatriazol derivative), and the NO-synthesis inhibitor; L-NAME were used. Endothelial cells were inc... | ['Animals', 'Arginine', 'Calcimycin', 'Cells, Cultured', 'Cyclic GMP', 'Endothelium, Vascular', 'Epoprostenol', 'Female', 'Molsidomine', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Rats', 'Rats, Wistar', 'Triazoles'] | 7,717,180 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D03.633.100.221.173'], ['A11.251'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['A07.015.700.500', 'A10.272.491.355'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['D03.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spontaneous mentalizing captures variability in the cortical thickness of social brain regions. | Theory of mind (ToM)--or thinking about the mental states of others--is a cornerstone of successful everyday social interaction. However, the brain bases of ToM are most frequently measured via explicit laboratory tasks that pose direct questions about mental states (e.g. "In this story, what does Steve think Julia bel... | ['Adolescent', 'Adult', 'Autistic Disorder', 'Brain Mapping', 'Cerebral Cortex', 'Culture', 'Emotions', 'Female', 'Goals', 'Humans', 'Individuality', 'Interpersonal Relations', 'Magnetic Resonance Imaging', 'Male', 'Photic Stimulation', 'Psychomotor Performance', 'Social Behavior', 'Theory of Mind', 'Young Adult'] | 24,847,726 | [['M01.060.057'], ['M01.060.116'], ['F03.625.164.113.500'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['I01.076.201.450', 'I01.880.853.100'], ['F01.470'], ['F01.658.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.488'], ['F01.829.401'],... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Characterization of lipid-rich aortic plaques by intravascular photoacoustic tomography: ex vivo and in vivo validation in a rabbit atherosclerosis model with histologic correlation. | BACKGROUND: Histologic studies have demonstrated that lipid content and its spatial distribution is related to plaque vulnerability. However, in vivo imaging is still limited. Photoacoustic imaging may provide novel in vivo insights into these lipid-rich plaques.OBJECTIVES: This study sought to examine whether intravas... | ['Animals', 'Aorta, Abdominal', 'Aorta, Thoracic', 'Aortic Diseases', 'Atherosclerosis', 'Disease Models, Animal', 'Imaging, Three-Dimensional', 'Lipids', 'Magnetic Resonance Imaging', 'Male', 'Photoacoustic Techniques', 'Plaque, Atherosclerotic', 'Rabbits', 'Reproducibility of Results', 'Ultrasonography, Interventiona... | 25,060,374 | [['B01.050'], ['A07.015.114.056.205'], ['A07.015.114.056.372'], ['C14.907.109'], ['C14.907.137.126.307'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.350.400', 'L01.224.308.410'], ['D10'], ['E01.370.350.825.500'], ['E01.370.565', 'E05.696'], ['C23.300.823'], ['B01.050.150.900.649.313.968.700'], ['E05.318.3... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Fasciolopsiasis in a five year old girl. | A 5 year old girl hailing from Keraniganj, presented with the complaints of fever, periumbilical pain and vomiting. In vomitus, Fasciolopsis buski worm in adult form was identified by naked eye examination. In stool, ova of Fasciolopsis buski were also observed under microscope. Clinically she was pale and had hepatome... | ['Animals', 'Anthelmintics', 'Child, Preschool', 'Diagnosis, Differential', 'Female', 'Humans', 'Praziquantel', 'Trematode Infections'] | 23,715,369 | [['B01.050'], ['D27.505.954.122.250.075'], ['M01.060.406.448'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.531.690'], ['C01.610.335.865']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fine structure of psammoma bodies at the outer aspect of blood vessels in meningioma. | Psammoma bodies at the perivascular area in five cases of meningioma were examined with the electron microscope. In general, meningocytic cells invest the outer aspect of blood vessels, which are constituted by multilayered basal laminae, collagen fibers, microfibrils, and pericytes. Remnants of degenerated cells are o... | ['Blood Vessels', 'Calcinosis', 'Electron Probe Microanalysis', 'Humans', 'Meningioma', 'Microscopy, Electron'] | 4,013,670 | [['A07.015'], ['C18.452.174.130'], ['E01.370.350.515.402.250', 'E05.196.867.800.360', 'E05.595.402.250', 'E05.799.830.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.580.520', 'C04.557.645.520', 'C04.588.614.250.580.500', 'C10.551.240.500.500'], ['E01.370.350.515.402', 'E05.595.402']] | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin. | The yeast cytosol contains multiple homologs of the DnaK and DnaJ chaperone family. Our current understanding of which homologs functionally interact is incomplete. Zuotin is a DnaJ homolog bound to the yeast ribosome. We have now identified the DnaK homolog Ssz1p/Pdr13p as zuotin's partner chaperone. Zuotin and Ssz1p ... | ['Cytosol', 'DNA-Binding Proteins', 'Dimerization', 'Escherichia coli Proteins', 'Fungal Proteins', 'HSP40 Heat-Shock Proteins', 'HSP70 Heat-Shock Proteins', 'Heat-Shock Proteins', 'Mitochondria', 'Molecular Chaperones', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins'] | 11,274,393 | [['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['D12.776.260'], ['G02.206', 'G03.230'], ['D12.776.097.275'], ['D12.776.354'], ['D12.776.580.216.292'], ['D12.776.580.216.375'], ['D12.776.580.216'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D12.776.580'], ['B01.300.107.795.785.800', '... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine. | Memories of learned associations between the rewarding properties of drugs and environmental cues contribute to craving and relapse in humans. The mesocorticolimbic dopamine (DA) system is involved in reward-related learning induced by drugs of abuse. DA D3 receptors are preferentially expressed in mesocorticolimbic DA... | ['Animals', 'Blotting, Western', 'Brain', 'Cocaine', 'Cocaine-Related Disorders', 'Conditioning, Psychological', 'Dopamine Uptake Inhibitors', 'Enzyme Activation', 'Female', 'Learning', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Mutant Strains', 'Receptors, Dopamine D3', 'Reward', 'Signal Transduction'] | 21,168,475 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A08.186.211'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['C25.775.300', 'F03.900.300'], ['F02.463.425.179'], ['D27.505.519.562.437.220', 'D27.505.519.625.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extracellular secretion of Escherichia coli heat-stable enterotoxin I across the outer membrane. | Escherichia coli heat-stable enterotoxin Ip (STIp) is an extracellular toxin consisting of 18 amino acid residues that is synthesized as a precursor of pre (amino acid residues 1 to 19), pro (amino acid residues 20 to 54), and mature (amino acid residues 55 to 72) regions. The precursor synthesized in the cytoplasm is ... | ['Amino Acid Sequence', 'Bacterial Toxins', 'Base Sequence', 'Biological Transport', 'Cell Wall', 'Enterotoxins', 'Escherichia coli', 'Escherichia coli Proteins', 'Molecular Sequence Data', 'Mutation'] | 9,171,378 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D23.946.123'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G03.143'], ['A11.284.183'], ['D23.946.330'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['L01.453.245.667'], ['G05.365.590']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Social factors affecting treatment of cervical cancer: ethical issues and policy implications. | Health care in the United States has become a privilege rather than a right. Patients who have the greatest need are the ones most likely to be denied this privilege. Despite recent advances in disease detection and treatment, many patients do not receive even the bare minimum of care. The high complexity of the health... | ['Adult', 'African Americans', 'Diagnostic Errors', 'Fatal Outcome', 'Female', 'Health Services Accessibility', 'Healthcare Disparities', 'Humans', 'Medicaid', 'Neoplasms, Squamous Cell', 'Social Support', 'State Health Plans', 'United States', 'Uterine Cervical Neoplasms'] | 18,310,380 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['E01.354', 'N02.421.450.280'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['N04.590.374.350', 'N05.300.430'], ['N04.590.374.380', 'N05.300.493'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Direct asymmetric aldol reactions of acetone using bimetallic zinc catalysts. | [reaction: see text] The enantioselective aldol reaction using a novel binuclear zinc catalyst of acetone with several aldehydes gave products in good yields (62-89%) with a high level of enantioselectivity (ee = 76-92%). | ['Acetone', 'Catalysis', 'Stereoisomerism', 'Zinc'] | 11,483,044 | [['D02.522.064'], ['G02.130'], ['G02.607.445.682'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ambient temperature detection of PCR amplicons with a novel sequence-specific nucleic acid lateral flow biosensor. | In the field of diagnostics, molecular amplification targeting unique genetic signature sequences has been widely used for rapid identification of infectious agents, which significantly aids physicians in determining the choice of treatment as well as providing important epidemiological data for surveillance and diseas... | ['Base Sequence', 'Biosensing Techniques', 'Cholera', 'Cholera Toxin', 'DNA, Bacterial', 'Gold', 'Humans', 'Limit of Detection', 'Molecular Sequence Data', 'Nanoparticles', 'Polymerase Chain Reaction', 'Reagent Strips', 'Sensitivity and Specificity', 'Temperature', 'Vibrio cholerae'] | 22,705,404 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.601.043'], ['C01.150.252.400.959.347'], ['D08.811.913.400.725.115.180', 'D23.946.123.194', 'D23.946.330.150'], ['D13.444.308.212'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
[A population survey on bone mineral density in a fishing village in Wakayama Prefecture (Part 2); The analysis of the risk factors affecting the bone mineral density]. | The purpose of this study was to detect factors affecting lumbar bone mineral density (BMD) of general inhabitants in a rural community. A cohort consisting of 2261 inhabitants aged 40-79 years was set up based on the resident registration in Taiji town, Wakayama Prefecture in 1992. Fifty men and 50 women in each of fo... | ['Adolescent', 'Adult', 'Aged', 'Body Composition', 'Bone Density', 'Cohort Studies', 'Diabetes Mellitus', 'Exercise', 'Female', 'Fisheries', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Population Surveillance', 'Pregnancy', 'Risk Factors', 'Rural Population'] | 8,952,327 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['G11.427.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C18.452.394.750', 'C19.246'], ['G11.427.410.698.277', 'I03.350'], ['J01.040.168.300', 'J03.540.280'], ['B01.050.150.900.649... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Efficacy of ivermectin against cutaneous Draschia and Habronema infection (summer sores) in horses. | Thirty-one horses with naturally occurring summer sores were given a single IM injection of 0.2 mg of ivermectin (22,23-dihydroavermectin B1)/kg during the summer of 1980. Larvae of Draschia and/or Habronema spp were recovered from biopsy samples taken from 21 of 25 horses (84%) on the day of anthelmintic treatment. Th... | ['Animals', 'Antiparasitic Agents', 'Horses', 'Ivermectin', 'Lactones', 'Larva', 'Nematode Infections', 'Seasons', 'Skin Diseases, Parasitic', 'Spirurida Infections', 'Spiruroidea'] | 6,461,283 | [['B01.050'], ['D27.505.954.122.250'], ['B01.050.150.900.649.313.984.235.472'], ['D02.540.576.500.997'], ['D02.540'], ['B05.500.500', 'G07.345.500.550.500.500'], ['C01.610.335.508'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['C01.610.858', 'C17.800.838.775'], ['C01.610.335.508.700.750'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Can we improve the general and nutritional management of elderly individuals living at a medical-social facility? A team work]. | Can we improve comprehensive care of old people's home residents? Working in an interdisciplinary health network, health professionals tried to better answer the real needs of residents. Malnutrition is is highly prevalent in this population. We showed that it is possible to improve health care of these patients by bet... | ['Aged', 'Anti-Bacterial Agents', 'Diet', 'Geriatrics', 'Homes for the Aged', 'Humans', 'Nutritional Status', 'Switzerland'] | 15,095,708 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['G07.203.650.240'], ['H02.403.355'], ['J03.775.462', 'N02.278.825.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.650', 'N01.224.425.525'], ['Z01.542.883']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. | The immune system develops in waves during ontogeny; it is initially populated by cells generated from fetal hematopoietic stem cells (HSCs) and later by cells derived from adult HSCs. Remarkably, the genetic programs that control these two distinct stem cell fates remain poorly understood. We report that Lin28b is spe... | ['Adult Stem Cells', 'Animals', 'B-Lymphocyte Subsets', 'B-Lymphocytes', 'Bone Marrow Cells', 'Cell Lineage', 'DNA-Binding Proteins', 'Fetal Blood', 'Fetus', 'Flow Cytometry', 'Hematopoietic Stem Cells', 'Humans', 'Liver', 'Lymphopoiesis', 'Mice', 'Mice, Inbred C57BL', 'MicroRNAs', 'Natural Killer T-Cells', 'RNA-Bindin... | 22,345,399 | [['A11.872.040'], ['B01.050'], ['A11.063.438.450', 'A11.118.637.555.567.550.450', 'A11.118.637.555.567.562.200', 'A15.145.229.637.555.567.550.450', 'A15.145.229.637.555.567.562.200', 'A15.382.032.438.450', 'A15.382.490.555.567.550.300', 'A15.382.490.555.567.562.450'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Transient hyperglycemia following intra-peritoneal irrigation with 5% glucose in a patient with pseudomyxoma peritonei]. | Pseudomyxoma peritonei is a condition characterized by the production of a large amount of mucopolysaccharide by a neoplastic epithelium. Although surgical removal of the mucinous ascites may be attempted, complete removal of the material is difficult. Thus, intra-peritoneal lavage with the liquid containing glucose or... | ['Aged', 'Anesthesia, General', 'Blood Glucose', 'Female', 'Glucose', 'Humans', 'Hyperglycemia', 'Monitoring, Physiologic', 'Peritoneal Lavage', 'Postoperative Complications', 'Pseudomyxoma Peritonei'] | 17,715,692 | [['M01.060.116.100'], ['E03.155.197'], ['D09.947.875.359.448.500'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.952'], ['E01.370.520'], ['E05.927.705'], ['C23.550.767'], ['C04.557.470.200.025.075.500', 'C04.557.470.590.075.500']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nifedipine aerosol attenuates airway constriction in dogs with hyperreactive airways. | We investigated the ability of a calcium channel blocker nifedipine, given as an aerosol, to attenuate bronchoconstriction induced by citric acid, Ascaris antigen, and methacholine in Basenji-Greyhound dogs. citric acid 10% increased pulmonary resistance (RL) 4.2-fold +/- 1.0 (mean +/- SEM) and 1.7-fold +/- 0.7 in untr... | ['Aerosols', 'Airway Resistance', 'Animals', 'Asthma', 'Bronchi', 'Bronchial Provocation Tests', 'Constriction, Pathologic', 'Dogs', 'Lung Compliance', 'Nifedipine', 'Pyridines'] | 6,849,541 | [['D20.280.055', 'D26.255.165.055'], ['E01.370.386.700.050', 'G09.772.060'], ['B01.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['A04.411.125'], ['E01.370.386.700.125'], ['C23.300.287'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.386.700.475', 'G09.772.540'], ['D03.383.72... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Heat shock induces the synthesis of the inflammatory mediator leukotriene B4 in human pulp cells. | AIM: To measure the synthesis of leukotriene B4 (LTB4) in cultures of human dental pulp cells induced by heat shock.METHODOLOGY: Primary pulp cells (PC) and dental pulp stem cells (DPSC) were cultivated under appropriate conditions. For the characterization of PC the expression of dentine sialophosphoprotein (DSPP) was... | ['Cells, Cultured', 'Dental Pulp', 'Extracellular Matrix Proteins', 'Hot Temperature', 'Humans', 'Inflammation Mediators', 'Leukotriene B4', 'Phosphoproteins', 'Protein Precursors', 'Sialoglycoproteins', 'Stem Cells', 'Time Factors'] | 16,343,115 | [['A11.251'], ['A14.549.167.900.260'], ['D12.776.860.300'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.469'], ['D10.251.355.255.100.450.411', 'D10.251.355.310.166.887.411'... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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