Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Conformational analysis of a glycosylated human myelin oligodendrocyte glycoprotein peptide epitope able to detect antibody response in multiple sclerosis. | Myelin oligodendrocyte glycoprotein (MOG), a minor myelin component, is an important central nervous system specific target autoantigen for primary demyelination in autoimmune diseases such as multiple sclerosis (MS). The native structure of MOG presents a glycosylation site at position 31 (Asn(31)). It has been recent... | ['Amino Acid Sequence', 'Antigens, Surface', 'Autoantibodies', 'Autoantigens', 'Epitopes', 'Glycosylation', 'Humans', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Molecular Sequence Data', 'Multiple Sclerosis', 'Myelin Proteins', 'Myelin-Associated Glycoprotein', 'Myelin-Oligodendrocyte Glycoprotein', 'Olig... | 11,428,934 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D23.050.301'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D23.050.422'], ['D23.050.550'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['E05.59... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Labile disulfide bonds and free thiol groups in human IgG. IV. Use of the "sigma S" value for postoperative monitoring of gynaecological malignant tumors. | "sigma S" comprises both disulfide bonds reactive to dithionitrobenzoate, as well as free SH groups of serum immunoglobulin G. In 38 cases of invasive gynaecological tumors, the value of sigma S was ascertained to be 1.04 +/- 0.25 (mean +/- SD), which, in accordance with former results, differs significantly from the r... | ['Adenocarcinoma', 'Carcinoma, Squamous Cell', 'Cystadenoma', 'Disulfides', 'Female', 'Genital Neoplasms, Female', 'Humans', 'Hysterectomy', 'Immunoglobulin G', 'Neoplasm Staging', 'Ovarian Neoplasms', 'Prognosis', 'Sulfhydryl Compounds', 'Uterine Cervical Neoplasms', 'Uterine Neoplasms'] | 2,922,933 | [['C04.557.470.200.025'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.557.470.035.320', 'C04.557.470.590.485'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['C04.588.945.418', 'C13.351.937.418'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['D12.776.124.486... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HIV-Nef Protein Persists in the Lungs of Aviremic Patients with HIV and Induces Endothelial Cell Death. | It remains a mystery why HIV-associated end-organ pathologies persist in the era of combined antiretroviral therapy (ART). One possible mechanism is the continued production of HIV-encoded proteins in latently HIV-infected T cells and macrophages. The proapoptotic protein HIV-Nef persists in the blood of ART-treated pa... | ['Animals', 'Apoptosis', 'Cell Death', 'Cell Line', 'Cell Line, Tumor', 'Cells, Cultured', 'Cytokines', 'Endothelial Cells', 'Endothelium', 'HEK293 Cells', 'HIV Infections', 'Humans', 'Jurkat Cells', 'Leukocytes, Mononuclear', 'Lung', 'Macrophages', 'Mice', 'Neoplasm Proteins', 'Pulmonary Emphysema', 'RNA-Binding Prote... | 30,321,057 | [['B01.050'], ['G04.146.954.035'], ['G04.146'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.436.275'], ['A10.272.491'], ['A11.251.210.172.750', 'A11.436.334'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.78... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors influencing university students' explicit and implicit sexual double standards. | Quantitative research has resulted in inconsistent evidence for the existence of a sexual double standard, leading Crawford and Popp ( 2003 ) to issue a call for methodological innovation. The implicit association test (IAT; Greenwald, McGhee, & Schwartz, 1998 ) is a measure that may provide a means to examine the doub... | ['Adolescent', 'Attitude', 'Female', 'Humans', 'Male', 'Sex Factors', 'Sexual Behavior', 'Sexual Partners', 'Social Desirability', 'Social Perception', 'Students', 'Universities', 'Young Adult'] | 21,534,028 | [['M01.060.057'], ['F01.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N05.715.350.675', 'N06.850.490.875'], ['F01.145.802'], ['M01.778'], ['F01.145.813.628'], ['F02.463.593.752'], ['M01.848'], ['I02.783.830', 'J03.832.830'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Heritability of ultimatum game responder behavior. | Experimental evidence suggests that many people are willing to deviate from materially maximizing strategies to punish unfair behavior. Even though little is known about the origins of such fairness preferences, it has been suggested that they have deep evolutionary roots and that they are crucial for maintaining and u... | ['Genetic Variation', 'Genetics, Behavioral', 'Genetics, Medical', 'Humans', 'Interpersonal Relations', 'Likelihood Functions', 'Phenotype', 'Play and Playthings', 'Punishment', 'Sweden'] | 17,909,184 | [['G05.365'], ['F04.096.276', 'H01.158.273.343.290'], ['H01.158.273.343.385.500', 'H02.403.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.... | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Fulminant hepatitis after grand mal seizures: mechanisms and role of liver transplantation. | Fulminant liver failure is a rare complication of grand mal seizures with a high mortality, the prognosis being largely determined by the combination of the hepatic and neurologic insults. The mechanisms of acute liver failure secondary to grand mal epilepsy and the place of liver transplantation in this context are po... | ['Adult', 'Chemical and Drug Induced Liver Injury', 'Epilepsy, Tonic-Clonic', 'Fatty Liver', 'Female', 'Humans', 'Hypoxia', 'Liver Failure', 'Liver Transplantation', 'Male', 'Middle Aged', 'Patient Selection', 'Prognosis', 'Survival Rate', 'Treatment Outcome'] | 12,883,489 | [['M01.060.116'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['C10.228.140.490.375.290'], ['C06.552.241'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['C06.552.308.500'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['M01.060.116.630'], ['E05.581.500.653',... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development of Optic Disc Torsion in Children. | PURPOSE: To document the development of disc torsion.METHODS: Consecutive disc photographs obtained at an interval of at least 1 year were reviewed retrospectively in 173 eyes of 173 Korean children. The angle of the vertical disc axis (AVDA) was measured in each fundus photograph with the fovea-disc center axis set at... | ['Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Optic Disk', 'Optic Nerve Diseases', 'ROC Curve', 'Refraction, Ocular', 'Refractive Errors', 'Retrospective Studies', 'Time Factors', 'Tomography, Optical Coherence', 'Torsion Abnormality', 'Visual Field Tests'] | 30,977,327 | [['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['C10.292.700', 'C11.640'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants. | Many carcinogenesis and tumorigenesis studies reported in the past several decades have relied upon bolus dose(s) of test compounds to determine their DNA damage and carcinogenic potential. The high doses are far from the human scenario where exposure is almost always to low doses and for long duration. In this study, ... | ['Animals', 'Aryl Hydrocarbon Hydroxylases', 'Benzo(a)pyrene', 'Carcinogens', 'Cytochrome P-450 CYP1A1', 'Cytochrome P-450 CYP1B1', 'DNA Adducts', 'DNA Damage', 'Drug Implants', 'Female', 'Gene Expression', 'Humans', 'Injections, Intraperitoneal', 'Liver', 'Lung', 'Mammary Glands, Animal', 'Phosphorus Radioisotopes', '... | 21,942,922 | [['B01.050'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['D02.455.426.559.847.799.306.300', 'D04.615.799.306.300'], ['D27.888.569.100'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.708.170.020.500', 'D12.776.422.220.453.010.332'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleostemin is a marker of proliferating stromal stem cells in adult human bone marrow. | The identification of stem cell-specific proteins and the elucidation of their novel regulatory pathways may help in the development of protocols for control of their self-renewal and differentiation for cell-based therapies. Nucleostemin is a recently discovered nucleolar protein predominantly associated with prolifer... | ['Adult', 'Base Sequence', 'Biomarkers', 'Bone Marrow Cells', 'Carrier Proteins', 'Cell Differentiation', 'Cell Nucleolus', 'Cell Proliferation', 'Fibroblast Growth Factor 2', 'GTP-Binding Proteins', 'Gene Expression Regulation', 'Humans', 'In Vitro Techniques', 'Multipotent Stem Cells', 'Nuclear Proteins', 'Phenotype'... | 16,282,439 | [['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D23.101'], ['A11.148', 'A15.378.316'], ['D12.776.157'], ['G04.152'], ['A11.284.430.106.279.345.175'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['D08.811.277.040.330.300', 'D12... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
The burden of mental ill health associated with childhood maltreatment in the UK, using The Health Improvement Network database: a population-based retrospective cohort study. | BACKGROUND: Childhood maltreatment is a global public health, human rights, and moral issue that is associated with a substantial mental health burden. We aimed to assess the association between childhood maltreatment and the development of mental ill health and the initiation of new prescriptions for mental ill health... | ['Child', 'Child Abuse', 'Cohort Studies', 'Cost of Illness', 'Databases, Factual', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Retrospective Studies', 'United Kingdom'] | 31,564,467 | [['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.31... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
[Nutrition in the elderly]. | It is well known that nutrition plays an important role in the maintenance of health through the whole life. Especially, nutrition in the elderly is thought to be necessary for keeping their life comfortable. How much calories should be needed in the elderly? In our country, daily allowance of total calories is 1600 kc... | ['Aged', 'Aged, 80 and over', 'Feeding Behavior', 'Female', 'Geriatric Assessment', 'Humans', 'Japan', 'Male', 'Nutritional Status'] | 2,352,353 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], [... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Development and regression of cochlear blood vessels in fetal and newborn mice. | Various strains of mice have been used for hearing research, but there have been few reports regarding the cochlear vasculature in mice. In this study, the development of the cochlear vasculature was investigated in C57BL/6 mice from day 15 of gestation to day 15 after birth, and mature vessels were also observed in 3-... | ['Animals', 'Animals, Newborn', 'Blood Vessels', 'Cochlea', 'Corrosion Casting', 'Embryo, Mammalian', 'Embryonic and Fetal Development', 'Mice', 'Mice, Inbred C57BL'] | 10,867,279 | [['B01.050'], ['B01.050.050.282'], ['A07.015'], ['A09.246.300.246'], ['E01.370.225.500.620.620.150', 'E01.370.225.750.600.620.150', 'E05.200.500.620.620.150', 'E05.200.750.600.620.150'], ['A16.254'], ['G07.345.500.325', 'G08.686.784.170'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B0... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10. | Cystic fibrosis (CF) patients continue to have reservoirs of Pseudomonas aeruginosa infection in their sinuses and trachea after transplantation, and studies indicate that nontransplanted CF patients have high bronchoalveolar lavage (BAL) levels of proinflammatory factors, interleukin-8 (IL-8), and elastase and decreas... | ['Adult', 'Bronchoalveolar Lavage Fluid', 'Cystic Fibrosis', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Interleukin-10', 'Interleukin-8', 'Leukocyte Elastase', 'Lung Transplantation', 'Maxillary Sinus', 'Middle Aged', 'Pseudomonas Infections', 'Trachea'] | 9,809,620 | [['M01.060.116'], ['E05.927.100.500'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Assessment of knowledge of Iranian occupational therapists of handling of children with cerebral palsy. | The purpose of this study was to assess the knowledge of Iranian occupational therapists regarding the handling of children with cerebral palsy and the application of their knowledge into practice. A questionnaire with two scales of a self-report and a knowledge-based test was designed. Data were analysed by using desc... | ['Adult', 'Baths', 'Caregivers', 'Cerebral Palsy', 'Child', 'Clinical Competence', 'Cross-Sectional Studies', 'Female', 'Humans', 'Iran', 'Male', 'Moving and Lifting Patients', 'Needs Assessment', 'Occupational Therapy', 'Surveys and Questionnaires', 'Young Adult'] | 24,390,931 | [['M01.060.116'], ['E02.056.110'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['C10.228.140.140.254'], ['M01.060.406'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Medico-legal notes for a new set of standards in the assessment of penal liability in psychiatry. | Negligence liability on the part of a psychiatrist belongs among high-complexity fields, for both the judge and his or her technical consultants. In most instances, there are no scientific grounds in order to ascribe with reasonable certainty liability to medical personnel and nursing staff, while often judges tend to ... | ['Depression', 'Humans', 'Italy', 'Liability, Legal', 'Malpractice', 'Mental Disorders', 'Physician-Patient Relations', 'Psychiatry', 'Suicide'] | 28,287,193 | [['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['I01.880.604.583.490', 'N03.706.535.547'], ['I01.880.604.583.524', 'N03.706.535.606'], ['F03'], ['F01.829.401.650.675', 'N05.300.660.625'], ['F04.096.544', 'H02.403.690'], ['F01.145.126.980.875', 'I01.880.735.856']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
[Status epilepticus: retrospective analysis of clinical characteristics over a 5-year period]. | Clinical features of status epilepticus (SE) were analysed retrospectively in a five-year period. Among 55 patients there were 65 episodes of SE, most frequently of generalised tonic-clonic type. There were also 7 episodes of simple motor, 5 of complex partial, 1 of petit mal and 4 of nonconvulsive "electric" SE. Seven... | ['Adult', 'Female', 'Humans', 'Male', 'Status Epilepticus'] | 2,102,552 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.742.785', 'C23.888.592.742.785']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of breathing via optoelectronic systems: comparison of four methods for computing breathing volumes and thoraco-abdominal motion pattern. | Breathing parameters can be measured by motion capture systems by placing photo-reflective markers on the chest wall. A computational model is mandatory to compute the breathing volume and to calculate temporal and kinematical features by the gathered markers trajectories. Despite different methods based on different g... | ['Abdomen', 'Biomechanical Phenomena', 'Computer Simulation', 'Electronics', 'Female', 'Humans', 'Lung', 'Male', 'Motion', 'Optics and Photonics', 'Organ Size', 'Plethysmography', 'Respiration', 'Spirometry', 'Statistics as Topic', 'Thoracic Wall', 'Thorax', 'Tidal Volume', 'Young Adult'] | 29,164,909 | [['A01.923.047'], ['G01.154.090', 'G01.374.089'], ['L01.224.160'], ['H01.671.293'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['G01.482'], ['H01.671.617', 'J01.293.688'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['E01.370.370.610'], ['G09.772.705'], ['E01... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 |
An Experience of Optimizing A Community-Based Micro-Insurance Model to Bridge the Gap between Treatment Cost and Ability to pay at BPKIHS. | In the year 2001 the leaders of BPKIHS started a micro social insurance scheme; Social Health Insurance (SHI) for prospective research. It is a method of financing and managing health care using compulsory contributions from employers, employees and may be from the government. Household members from organized groups in... | ['Focus Groups', 'Humans', 'Insurance, Health', 'Models, Economic', 'Nepal', 'Social Security'] | 28,598,462 | [['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343'], ['E05.318.740.500.600', 'E05.599.835.890', 'N05.715.360.750.530.500', 'N06.850.520.830.500.600'], ['Z01.252.245.674'], ['N03.219.521.346.506.849', 'N03.219.521.576.823']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Sex differences in gastric mucosal protection after 16, 16-dimethyl PGE2 and lithium chloride. | While the incidence of duodenal ulcer disease has been documented to be greater in men than in women, this observation has not been previously noted in animal studies of the upper gastrointestinal tract. In this study, we questioned whether the cytoprotective properties of 16, 16-dimethyl PGE2 were sex-related by compa... | ['16,16-Dimethylprostaglandin E2', 'Animals', 'Chlorides', 'Ethanol', 'Female', 'Gastric Mucosa', 'Gastritis', 'Gastrointestinal Hemorrhage', 'Lithium', 'Lithium Chloride', 'Male', 'Peptic Ulcer', 'Prostaglandins E, Synthetic', 'Rats', 'Rats, Inbred Strains', 'Sex Factors'] | 3,025,937 | [['D10.251.355.255.550.775.450.300', 'D23.469.050.175.725.775.450.300', 'D23.469.700.660.200'], ['B01.050'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D02.033.375'], ['A03.556.875.875.440', 'A10.615.550.291'], ['C06.405.205.697', 'C06.405.748.398'], ['C06.405.227', 'C23.550.414.788'], ['D01.268.549.450', 'D01.268.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Significance of autopsy in patients with head and neck cancer]. | BACKGROUND: Nowadays, the morphological assessment of samples obtained from living patients has a greater importance than the scientific knowledge which is gained by autopsy. Therefore, the aim of the study was a retrospective analysis of causes of death in patients with head and neck cancer.MATERIAL AND METHODS: The a... | ['Adult', 'Aged', 'Aged, 80 and over', 'Autopsy', 'Biopsy', 'Cause of Death', 'Comorbidity', 'Disease Progression', 'Disease-Free Survival', 'Female', 'Germany', 'Humans', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Grading', 'Neoplasm Staging', 'Otorhinolaryngologic Neoplasms', 'Predictive Value of Tests'... | 22,477,387 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.50... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Diabetes in urban African Americans: functional health literacy of municipal hospital outpatients with diabetes. | Functional health literacy was assessed in 63 patients from the diabetes outpatient clinic, 20 from the general medicine clinic, and a total of 48 from two satellite medical clinics. All patients received a demographic questionnaire, visual screening, and the Test of Functional Health Literacy in Adults, an instrument ... | ['Adult', 'African Americans', 'Aged', 'Diabetes Mellitus, Type 2', 'Educational Status', 'Female', 'Hospitals, Municipal', 'Humans', 'Male', 'Middle Aged', 'Outpatients', 'Patient Education as Topic', 'Surveys and Questionnaires', 'Urban Population'] | 9,355,373 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.116.100'], ['C18.452.394.750.149', 'C19.246.300'], ['N01.824.196'], ['N02.278.421.510.210', 'N02.278.421.660.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.643.630'], ['I02.233.332.500', 'N02.421.726.407.680'], [... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Association of corticosteroids use and outcomes in COVID-19 patients: A systematic review and meta-analysis. | BACKGROUND: To systematically review the literature about the association between systemic corticosteroid therapy (CST) and outcomes of COVID-19 patients.METHODS: We searched Medline, Embase, EBM Reviews, Scopus, Web of Science, and preprints up to July 20, 2020. We included observational studies and randomized control... | ['Adrenal Cortex Hormones', 'Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Hospitalization', 'Humans', 'Observational Studies as Topic', 'Pandemics', 'Pneumonia, Viral', 'Randomized Controlled Trials as Topic', 'SARS-CoV-2', 'Treatment Outcome'] | 33,008,778 | [['D06.472.040'], ['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Variability in cardiovascular and plasma norepinephrine responses to head-up tilt in healthy human subjects. | Eight healthy, young adult males underwent three separate, 10-min 70 degrees head-up tilts (HUT) over a period of nine days, in order to assess the intra- and inter-individual variability of cardiovascular and plasma norepinephrine (NE) responses to the manoeuvre. Cardiovascular parameters and plasma NE were measured i... | ['Adult', 'Blood Pressure', 'Cardiography, Impedance', 'Electrocardiography', 'Heart Rate', 'Hemodynamics', 'Humans', 'Male', 'Norepinephrine', 'Posture'] | 1,787,258 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.160', 'E01.370.370.610.610.200'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.600.875.500', 'G09.330.380.500'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Determining early gastric cancer lesions appropriate for endoscopic submucosal dissection trainees: a proposal related to curability. | Endoscopic submucosal dissection (ESD) was introduced worldwide as a new treatment option for early gastric cancer. Our objective was to discuss the limited ESD reports available and to determine the lesions suitable for use in training endoscopists on which lesions are appropriate for ESD. We reviewed a series of ESD ... | ['Clinical Competence', 'Dissection', 'Endoscopy, Gastrointestinal', 'Humans', 'Intestinal Mucosa', 'Risk Assessment', 'Risk Factors', 'Stomach Neoplasms', 'Stomach Ulcer'] | 22,533,771 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E01.370.225.998.221', 'E04.221', 'E05.200.998.221'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.369', 'A10.615.550.444'], ['E05.318.740.600.800.715', 'N... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Isocratic separation of PTH-amino acids at picomole level by reverse-phase HPLC in the presence of sodium dodecylsulfate. | The phenylthiohydantoin (PTH) derivatives of protein amino acids have been separated by reverse-phase high performance liquid chromatography (HPLC) on a fully end-capped C18 column using an isocratic solvent system. The developing solvent was 0.01 M sodium acetate buffer (pH 4.5) containing 39.5% acetonitrile and 0.02%... | ['Amino Acids', 'Autoanalysis', 'Chromatography, High Pressure Liquid', 'Hydantoins', 'Microchemistry', 'Phenylthiohydantoin', 'Sodium Dodecyl Sulfate', 'Time Factors'] | 4,008,475 | [['D12.125'], ['E05.059'], ['E05.196.181.400.300'], ['D03.383.129.308.432.555'], ['E05.196.620', 'H01.181.650'], ['D03.383.129.308.432.555.868.650'], ['D02.033.415.220.720', 'D02.886.645.600.055.050.632', 'D10.289.220.720'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Luteinizing hormone secretion after withdrawal of exogenous progestogen in heifers fed three levels of dietary energy. | As experiment was conducted with 15 Angus X Hereford heifers that were 16 mo of age at the time the experiment was initiated. The heifers were assigned randomly in equal numbers to be fed low (L), maintenance (M) or high (H) energy diets for 191 d. Overall average weight for heifers at the time the experiment was initi... | ['Animals', 'Body Weight', 'Cattle', 'Diet', 'Drug Combinations', 'Drug Implants', 'Energy Metabolism', 'Estradiol', 'Estrus', 'Female', 'Luteinizing Hormone', 'Pregnancy', 'Pregnenediones', 'Progesterone'] | 6,546,564 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.650.240'], ['D26.310'], ['D26.255.210.315'], ['G03.295'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G08.686.195.500'], ['D... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fast color grouping and slow color inhibition: evidence for distinct temporal windows for separate processes in preview search. | The authors report 4 experiments that examined color grouping and negative carryover effects in preview search via a probe detection task (J. J. Braithwaite, G. W. Humphreys, & J. Hodsoll, 2003). In Experiment 1, there was evidence of a negative color carryover from the preview to new items, using both search and probe... | ['Adolescent', 'Adult', 'Attention', 'Color Perception', 'Female', 'Humans', 'Inhibition, Psychological', 'Male', 'Reaction Time', 'Time Factors', 'Visual Perception'] | 17,563,218 | [['M01.060.057'], ['M01.060.116'], ['F02.830.104.214'], ['F02.463.593.932.217'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.544', 'F02.463.425.475', 'F02.739.794.405'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['G01.910.857'], ['F02.463.593.932']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Simultaneous quantification of Schisandrin B enantiomers in rat plasma by chiral LC-MS/MS: Application in a stereoselective pharmacokinetic study. | Schisandrin B (Sch B) has received much attention owing to its various biological activities. Schisandrin B exists as a racemate in "wuweizi", a traditional Chinese medicine in China. In the present study, a novel chiral LC-MS/MS method was developed for enantioselective separation and determination of Schisandrin B in... | ['Animals', 'Anti-Inflammatory Agents', 'Chromatography, Liquid', 'Cyclooctanes', 'Dioxoles', 'Lignans', 'Male', 'Polycyclic Compounds', 'Rats', 'Rats, Sprague-Dawley', 'Stereoisomerism', 'Tandem Mass Spectrometry'] | 29,990,885 | [['B01.050'], ['D27.505.954.158'], ['E05.196.181.400'], ['D02.455.426.392.368.408'], ['D03.383.246'], ['D02.455.426.559.389.140.450'], ['D04'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['G02.607.445.682'], ['E05.196.566.880']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. | VLA-4 plays a critical role in T cell trafficking into inflammatory sites. Our recent studies have suggested that VLA-4 expression on CD8+ T cells is negatively controlled by IL-4 and serves as a functionally distinguishing variable for why Type-1, but not Type-2, CD8+ T cells are able to traffic into tumors. In this s... | ['Animals', 'CD8-Positive T-Lymphocytes', 'Down-Regulation', 'Integrin alpha4beta1', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Neoplasms', 'Phosphatidylinositol 3-Kinases', 'Protein Transport', 'STAT6 Transcription Factor', 'Signal Transduction', 'Vascular Cell Adhesion Molecule-1'] | 18,566,374 | [['B01.050'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D12.776.395.550.200.625.347', 'D12.776.543.550.200.625.347', 'D12.776.543.750.705.408.530.500', 'D12.776.543.750.705.408.850.299', 'D12.776.543.750.705.87... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alternative oral exemestane formulation: improved dissolution and permeation. | Exemestane (EXE) is an irreversible aromatase inactivator used for the treatment of advanced postmenopausal breast cancer. EXE is orally active but its bioavailability is about 5% due to its low solubility in water and the extensive first pass effect. It is known that cyclodextrin (CD) complexation enhances solubility ... | ['Administration, Oral', 'Androstadienes', 'Caco-2 Cells', 'Chemistry, Pharmaceutical', 'Humans', 'Permeability', 'Solubility', 'X-Ray Diffraction'] | 20,678,561 | [['E02.319.267.100'], ['D04.210.500.054.079.129'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['H01.158.703.007', 'H01.181.466'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.723'], ['G02.805'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact craters as biospheric microenvironments, Lawn Hill Structure, Northern Australia. | Impact craters on Mars act as traps for eolian sediment and in the past may have provided suitable microenvironments that could have supported and preserved a stressed biosphere. If this is so, terrestrial impact structures such as the 18-km-diameter Lawn Hill Structure, in northern Australia, may prove useful as marti... | ['Ecosystem', 'Exobiology', 'Extraterrestrial Environment', 'Geography', 'Geologic Sediments', 'Ice Cover', 'Mars', 'Meteoroids', 'Models, Theoretical', 'Northern Territory', 'Water Microbiology'] | 16,689,651 | [['G16.500.275.157', 'N06.230.124'], ['H01.158.273.295'], ['G01.060.075.159', 'G16.500.275.240'], ['H01.277.500'], ['G01.311.330', 'G16.500.320'], ['G01.311.400', 'G16.500.275.410.500', 'N06.230.291.500'], ['G01.060.075.730.700.625'], ['G01.060.075.500'], ['E05.599'], ['Z01.639.100.875', 'Z01.678.100.373.875'], ['H01.1... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
The impact of transgenic mosquitoes on dengue virulence to humans and mosquitoes. | Dengue is a major public health concern in the tropics and subtropics. Innovative transgenic strategies to render Aedes aegypti mosquitoes, the primary vector of dengue, incompetent for dengue transmission are under development. We modeled the evolutionary impact of different transgenic mosquito strategies on dengue-in... | ['Aedes', 'Animals', 'Animals, Genetically Modified', 'Dengue', 'Dengue Virus', 'Feeding Behavior', 'Humans', 'Insect Vectors', 'Models, Genetic', 'Selection, Genetic', 'Virulence'] | 19,737,112 | [['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['C01.920.500.270', 'C01.925.081.270', 'C01.925.782.350.250.214', 'C01.925.782.417.214'], ['B04.820.578.344.350.270'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.4... | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Children unable to perform screening tests in vision in preschoolers study: proportion with ocular conditions and impact on measures of test accuracy. | PURPOSE: To examine the relative prevalence of ocular conditions among children who are unable to perform preschool vision screening tests and the impact on measures of screening test performance.METHODS: Trained nurse and lay screeners each administered a Lea Symbols visual acuity (VA) test (Good-Lite, Inc., Steamwood... | ['Allied Health Personnel', 'Amblyopia', 'Child, Preschool', 'False Positive Reactions', 'Female', 'Humans', 'Male', 'Pediatric Nursing', 'Predictive Value of Tests', 'Prevalence', 'Refractive Errors', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Strabismus', 'Vision Screening', 'Visual Acuity', 'Workf... | 17,197,520 | [['M01.526.485.067', 'N02.360.067'], ['C10.228.140.055', 'C10.597.751.941.073', 'C11.966.073', 'C23.888.592.763.941.073'], ['M01.060.406.448'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.478.676.631', 'N02.421.533.691'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.80... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Targeted cytoplasmic irradiation and autophagy. | The effect of ionizing irradiation on cytoplasmic organelles is often underestimated because the general dogma considers direct DNA damage in the nuclei to be the primary cause of radiation induced toxicity. Using a precision microbeam irradiator, we examined the changes in mitochondrial dynamics and functions triggere... | ['Alpha Particles', 'Apoptosis', 'Autophagy', 'Cells, Cultured', 'Cytoplasm', 'Epithelial Cells', 'Humans', 'Mitochondrial Dynamics', 'Reactive Oxygen Species', 'Respiratory System', 'TOR Serine-Threonine Kinases'] | 28,283,188 | [['G01.750.750.055'], ['G04.146.954.035'], ['G04.011'], ['A11.251'], ['A11.284.430.214'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G04.599.750'], ['D01.339.431', 'D01.650.775'], ['A04'], ['D08.811.913.696.620.682.700.931', 'D12.776.476.925']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular requirements for kinetochore-associated microtubule formation in mammalian cells. | In centrosome-containing cells, microtubules nucleated at centrosomes are thought to play a major role in spindle assembly. In addition, microtubule formation at kinetochores has also been observed, most recently under physiological conditions in live cells. The relative contributions of microtubule formation at kineto... | ['Animals', 'Cell Cycle Proteins', 'Cells, Cultured', 'Dyneins', 'Kinetochores', 'Microtubule-Associated Proteins', 'Microtubules', 'Models, Biological', 'Nuclear Proteins', 'Spindle Apparatus', 'Tubulin', 'ran GTP-Binding Protein'] | 16,527,751 | [['B01.050'], ['D12.776.167'], ['A11.251'], ['D08.811.277.040.013.500.063', 'D08.811.277.040.025.024.063', 'D08.811.277.040.025.193.249', 'D12.776.157.025.750.063', 'D12.776.220.600.200'], ['A11.284.430.106.279.345.190.160.165.500', 'G05.360.160.165.500'], ['D12.776.220.600.450', 'D12.776.631.560'], ['A11.284.430.214.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacological prevention of postoperative adhesions experimentally induced in the rat. | In order to evaluate the preventive action of certain drugs in the formation of adhesions, three different types of trauma were induced in the uterine horns of 105 female Wistar rats. The animals were divided into six groups of 15 rats each and to each group was administered respectively: aprotinin i.p.; hydrocortisone... | ['Animals', 'Aprotinin', 'Colchicine', 'Dextrans', 'Female', 'Hydrocortisone', 'Injections, Intramuscular', 'Injections, Intraperitoneal', 'Postoperative Complications', 'Rats', 'Rats, Inbred Strains', 'Sodium Chloride', 'Tissue Adhesions', 'Uterus'] | 2,437,747 | [['B01.050'], ['D12.776.083'], ['D03.132.225'], ['D05.750.078.562.272', 'D09.698.365.272'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['E02.319.267.530.460'], ['E02.319.267.530.490'], ['C23.550.767'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Therapeutic activity of pretazettine, standard drugs, and the combinations on intraperitoneally implanted Lewis lung carcinoma in mice. | Therapeutic effectiveness of pretazettine (PTZ) has been demonstrated in the intraperitoneally (i.p.) implanted Lewis lung carcinoma (LLC) in both syngeneic and allogeneic mice. The i.p. implanted LLC has been found to be sensitive to most standard drugs tested such as cyclophosphamide (CY), actinomycin D, 5-fluorourac... | ['Alkaloids', 'Amaryllidaceae Alkaloids', 'Animals', 'Antineoplastic Agents', 'Cyclophosphamide', 'Drug Therapy, Combination', 'Fluorouracil', 'Lung Neoplasms', 'Mice', 'Mice, Inbred A', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Neoplasms, Experimental'] | 6,872,620 | [['D03.132'], ['D03.132.052'], ['B01.050'], ['D27.505.954.248'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['E02.319.310'], ['D03.383.742.698.875.404'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.300', 'B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reliability and validity of the Turkish version of the mini Osteoporosis Quality of Life Questionnaire. | OBJECTIVE: The purpose of this study was to develop a Turkish version of the mini Osteoporosis Quality of Life Questionnaire (mini-OQLQ), and assess its reliability and validity.MATERIAL AND METHOD: Sixty-four women with postmenopausal osteoporosis were included in the study. Patients who were diagnosed with secondary ... | ['Activities of Daily Living', 'Aged', 'Female', 'Fractures, Bone', 'Humans', 'Language', 'Lumbar Vertebrae', 'Middle Aged', 'Motor Activity', 'Osteoporosis, Postmenopausal', 'Quality of Life', 'Reproducibility of Results', 'Surveys and Questionnaires', 'Turkey'] | 22,684,199 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['F01.145.632', 'G11.427.410.698'], ['C05.116.198.579.610', 'C18.452.104.579.610'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Huma... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Characterization and fate of polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in soils and sediments at the Portsmouth Gaseous Diffusion Plant, Ohio. | The U.S. Department of Energy Portsmouth Gaseous Diffusion Plant is in the early stages of decommissioning and decontamination. During operations, the site drew a large amount of electric power and had multiple large switchyards on site. These are a source of polychlorinated biphenyls (PCB) contamination to both on-sit... | ['Benzofurans', 'Dibenzofurans, Polychlorinated', 'Geologic Sediments', 'Ohio', 'Polychlorinated Biphenyls', 'Polychlorinated Dibenzodioxins', 'Rivers', 'Soil', 'Soil Pollutants'] | 25,113,188 | [['D03.633.100.127'], ['D02.309.250', 'D03.633.300.258.500'], ['G01.311.330', 'G16.500.320'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', 'Z01.107.567.875.510.540'], ['D02.309.750', 'D02.455.426.559.389.185.698', 'D02.455.526.439.773'], ['D02.309.500.450', 'D03.633.300.786'], ['G01.311.750', 'G16.500.275.280... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Preparation and characterization of polyethyl-2-cyanoacrylate nanocapsules containing antiepileptic drugs. | Biocompatible and biodegradable colloidal drug delivery systems can be obtained by means of in situ polymerization of alkylcyanoacrylate. In particular, nanocapsules of polyethylcyanoacrylate (PECA) were prepared by adding the monomer to an organic phase, consisting of Miglyol 812 and an organic solvent (ethanol, aceto... | ['Acetone', 'Acetonitriles', 'Anticonvulsants', 'Biocompatible Materials', 'Carbamazepine', 'Cyanoacrylates', 'Diffusion', 'Drug Compounding', 'Drug Delivery Systems', 'Ethanol', 'Ethosuximide', 'Freeze Fracturing', 'Membranes, Artificial', 'Microscopy, Electron', 'Phenytoin', 'Poloxalene', 'Scattering, Radiation', 'Su... | 8,730,958 | [['D02.522.064'], ['D02.626.080'], ['D27.505.954.427.080'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D03.633.300.240.127'], ['D02.241.081.069.366', 'D02.626.290', 'D05.750.259', 'D25.720.259', 'D25.919.367', 'J01.637.051.720.259', 'J01.637.051.919.367'], ['G01.202', 'G02.196'], ['E05.916.270'], ['E02.319.30... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A comparison of static and dynamic ?B0 | PURPOSE: To assess the performance, in the presence of scanner instabilities, of three dynamic correction methods which integrate ?B0 mapping into the chemical exchange saturation transfer (CEST) measurement and three established static ?B0 -correction approaches.METHODS: A homogeneous phantom and five healthy voluntee... | ['Adult', 'Brain', 'Echo-Planar Imaging', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Phantoms, Imaging'] | 30,924,210 | [['M01.060.116'], ['A08.186.211'], ['E01.370.350.825.500.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['E07.671']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Safety and efficacy of specific sublingual immunotherapy in patients with asthma and allergy to Dermatophagoides pteronyssinus]. | BACKGROUND: First reports on sublingual immunotherapy were published in 1980.OBJECTIVE: To compare safety and effectiveness of sublingual immunotherapy, as compared with placebo, in asthmatic patients.MATERIALS: In a blinded randomized controlled trial asthmatic patients with positive skin prick tests to Dermatophagoid... | ['Administration, Sublingual', 'Adolescent', 'Adult', 'Allergens', 'Asthma', 'Dermatophagoides pteronyssinus', 'Female', 'Humans', 'Immunotherapy', 'Male', 'Middle Aged', 'Single-Blind Method'] | 16,568,708 | [['E02.319.267.100.878'], ['M01.060.057'], ['M01.060.116'], ['D23.050.063'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['B01.050.500.131.166.132.419.600.215'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425'], ['M01.060.116.630'], ['E05.318.370.850', 'N05.715.360.325.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fetal diagnosis of an "extra cardiac chamber". | Congenital right ventricular aneurysms and diverticula are rare congenital anomalies and prenatal detection is uncommon. Distinguishing between these two anomalies by imaging alone is difficult. Recently, we were asked to review a 21-week ultrasound that detected an "extra cardiac chamber." This represents the first re... | ['Dilatation, Pathologic', 'Diverticulum', 'Female', 'Heart Defects, Congenital', 'Heart Diseases', 'Heart Ventricles', 'Humans', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Ultrasonography, Prenatal'] | 17,912,484 | [['C23.300.325'], ['C06.405.205.282.750', 'C23.300.415'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['C14.280'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E01.370.350.825.500'], ['E01.370.350.850.865', 'E01.370.378.630.865']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Concealed pheochromocytoma presenting as recurrent acute coronary syndrome with STEMI : case report of a patient with hyperthyroidism. | Pheochromocytomas are rare, primarily benign tumors of chromaffin cells that secrete catecholamines. Although they are curable when diagnosed early, they can be fatal if undiagnosed or mistreated. Pheochromocytoma causing acute myocardial infarction has been reported as presenting with either unstable angina with EKG c... | ['Acute Coronary Syndrome', 'Diagnosis, Differential', 'Female', 'Humans', 'Hyperthyroidism', 'Myocardial Infarction', 'Pheochromocytoma', 'Recurrence', 'Retroperitoneal Neoplasms', 'Young Adult'] | 23,880,945 | [['C14.280.647.124', 'C14.907.585.124'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.397'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['C04.557.465.625.650.700.725', 'C04.557.580.625.650.700.725'], ['C23.550.291.937'], ['C04.588.033.731'], ['M01.06... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Orphan nuclear receptor TR3/Nur77 differentially regulates the expression of integrins in angiogenesis. | Pathological angiogenesis is a hallmark of many diseases. Previously, we reported that orphan nuclear receptor TR3/Nur77 (human homolog, Nur77, mouse homolog) is a critical mediator of angiogenesis to regulate tumor growth and skin wound healing via down-regulating the expression of the junctional proteins and integrin... | ['Angiogenesis Inducing Agents', 'Binding Sites', 'Cell Adhesion', 'Cell Movement', 'Cell Proliferation', 'Cells, Cultured', 'Endothelial Cells', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Integrins', 'Microvessels', 'Neovascularization, Physiologic', 'Nuclear Receptor Subfamily 4, Group A, Member 1', 'Promot... | 30,391,133 | [['D27.505.696.377.077.077'], ['G02.111.570.120'], ['G04.022'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['A11.436.275'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408'], ['A07.015.461'], ['G09.330.630'], ['D12.776.260.643.400... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target. | Inappropriate upregulation of cyclooxygenase-2 (COX-2) and matrix metalloproteinases (MMPs) has been implicated in the pathogenesis of various types of cancer. In the present study, we investigated the effects of hirsutenone, a diarylheptanoid isolated from the medicinal plant Alnus hirsuta var. sibirica, on the expres... | ['Active Transport, Cell Nucleus', 'Catechols', 'Cell Line', 'Cell Movement', 'Cyclooxygenase 2', 'Diarylheptanoids', 'Dinoprostone', 'Epithelial Cells', 'Gene Expression Regulation, Enzymologic', 'Genes, Reporter', 'Humans', 'Mammary Glands, Human', 'Matrix Metalloproteinase 9', 'Membrane Proteins', 'Molecular Structu... | 16,380,122 | [['G03.143.310.100', 'G03.143.700.100'], ['D02.455.426.559.389.657.166'], ['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['D08.811.600.720.750'], ['D02.455.326.146.485.222', 'D02.455.426.559.694'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['A11.436'], ['G05.308.320'], ['G05.360.340.024.340.435'... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Measuring Rural Food Environments for Local Action in Australia: A Systematic Critical Synthesis Review. | Poor diet is a significant contributor to obesity and chronic disease. With all being more prevalent in rural than urban Australia, modifying the food environment is a potential intervention point to improve the health of rural populations. This review examined the applicability of measurement tools used in rural food ... | ['Australia', 'Commerce', 'Cross-Sectional Studies', 'Environment', 'Food', 'Humans', 'Obesity', 'Rural Population'] | 31,284,678 | [['Z01.639.100', 'Z01.678.100.373'], ['J01.219'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G16.500.275', 'N06.230'], ['G07.203.300', 'J02.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07... | ['Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Primary papillary carcinoma of the prostate: report of a histopathologic, cytologic and electron microscopic study on one case. | An unusual type of prostatic carcinoma is described. Histopathologic examination showed a papillary and acinar appearance. Aspiration cytology showed papillary fragments and sheets of malignant cells. The ultrastructural features of this tumor were similar to those reported for prostatic carcinoma rather than endometri... | ['Aged', 'Biopsy, Needle', 'Carcinoma, Papillary', 'Cell Nucleus', 'Desmosomes', 'Endoplasmic Reticulum', 'Humans', 'Male', 'Microscopy, Electron', 'Microvilli', 'Mitochondria', 'Organoids', 'Prostate', 'Prostatic Neoplasms', 'Vacuoles'] | 269,605 | [['M01.060.116.100'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.14... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Cellular immune reactivity in patients with multiple myeloma]. | The ConA-, PHA- and PWM-induced lymphocyte transformation rates were significantly decreased in 19 patients with multiple myeloma. Lymphocyte-inherent defects rather than serum factors seem to account for this decreased lymphocyte reactivity. In 58% of the patients a pathologically increased ConA-induced suppressor cel... | ['Humans', 'Immunity, Cellular', 'Immunoglobulin M', 'Lymphocyte Activation', 'Multiple Myeloma', 'T-Lymphocytes, Regulatory'] | 158,933 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['D12.776.124.486.485.114.619.574', 'D12.776.124.790.651.114.619.574', 'D12.776.377.715.548.114.619.574'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['C04.557.595.500', 'C14.907.454.460', 'C15.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GLUT9 is differentially expressed and targeted in the preimplantation embryo. | During preimplantation development in the mouse, it is crucial that glucose metabolism not be compromised. Any decrease in glucose uptake at this stage in development can compromise the developing embryo. We have cloned another member of the glucose transporter family, GLUT9, which is expressed embryonically. Three dif... | ['Amino Acid Sequence', 'Animals', 'Blastocyst', 'Cloning, Molecular', 'Female', 'Gene Expression Regulation, Developmental', 'Glucose', 'Glucose Transport Proteins, Facilitative', 'Mice', 'Mice, Inbred Strains', 'Molecular Sequence Data', 'Monosaccharide Transport Proteins'] | 14,657,010 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A16.254.500'], ['E05.393.220'], ['G05.308.310'], ['D09.947.875.359.448'], ['D12.776.157.530.500.500', 'D12.776.157.530.937.563', 'D12.776.543.585.500.500', 'D12.776.543.585.937.625'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Issues associated with the emergence of coeliac disease in the Asia–Pacific region: a working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology. | BACKGROUND AND AIM: Once thought to be uncommon in Asia, coeliac disease (CD) is now being increasingly recognized in Asia–Pacific region. In many Asian nations, CD is still considered to be either nonexistent or very rare. In recognition of such heterogeneity of knowledge and awareness, the World Gastroenterology Orga... | ['Asia', 'Celiac Disease', 'Diet, Gluten-Free', 'Gastroenterology', 'Genetic Testing', 'Humans', 'Prevalence', 'Serologic Tests', 'Societies, Medical'] | 24,783,246 | [['Z01.252'], ['C06.405.469.637.250', 'C18.452.603.250'], ['E02.642.249.265', 'G07.203.650.240.265'], ['H02.403.429.405'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06... | ['Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Streptomyces fuscichromogenes sp. nov., an actinomycete from soil. | A novel actinomycete, designated strain m16T, was isolated from a soil sample collected from the tropical rain forest of Xishuangbanna, a prefecture in Yunnan Province, south-west China, and characterized by using polyphasic taxomomy. Cells were aerobic and Gram-reaction-positive, and spore chains were observed to be o... | ['Bacterial Typing Techniques', 'Base Composition', 'China', 'DNA, Bacterial', 'Diaminopimelic Acid', 'Fatty Acids', 'Nucleic Acid Hybridization', 'Phylogeny', 'RNA, Ribosomal, 16S', 'Rainforest', 'Sequence Analysis, DNA', 'Soil Microbiology', 'Streptomyces', 'Tropical Climate', 'Vitamin K 2'] | 27,902,221 | [['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['G02.111.080'], ['Z01.252.474.164'], ['D13.444.308.212'], ['D02.241.081.337.699.250', 'D12.125.095.390'], ['D10.251'], ['E05.393.661', 'G02.111.611'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686.670'], ['G16.500.275.157.437.500', 'N06.230.124.343.50... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Symptomatic type II protein C deficiency caused by a missense mutation (Gly 381-->Ser) in the substrate-binding pocket. | A patient with recurrent deep vein thrombosis and heterozygous type II deficiency, characterized by reduced protein C activity in both amidolytic and clotting functional assays, was investigated by direct sequencing of PCR fragments derived from the coding portion of the protein C gene. AG (8856) to A transition was no... | ['Adult', 'Base Sequence', 'Chromosome Mapping', 'Computer Simulation', 'Female', 'Femoral Vein', 'Humans', 'Models, Genetic', 'Models, Molecular', 'Molecular Sequence Data', 'Mutation', 'Polymerase Chain Reaction', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Protein C', 'Protein C Deficiency', 'Thrombosis... | 8,398,832 | [['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['L01.224.160'], ['A07.015.908.314'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.397'], ['E05.599.595'], ['L01.453.245.667'], ['G05.365.590'], ['E05.393.620.500'], ['G08.686.784.769'], ['C13.703.634', 'C14.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40. | Murine gammaherpesvirus 68 (gammaHV68), like Epstein-Barr virus (EBV), establishes a chronic infection in its host by gaining access to the memory B-cell reservoir, where it persists undetected by the host's immune system. EBV encodes a membrane protein, LMP1, that appears to function as a constitutively active CD40 re... | ['Animals', 'B-Lymphocytes', 'CD40 Antigens', 'Chronic Disease', 'Herpesviridae Infections', 'Lung', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Rhadinovirus', 'Spleen', 'Tumor Virus Infections', 'Virus Activation', 'Virus Replication'] | 15,709,008 | [['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D12.776.465.750', 'D12.776.543.750.705.852.760.097', 'D23.050.301.264.051.140', 'D23.101.100.150.140'], ['C23.550.291.500'], ['C01.925.256.466'], ['A04.411'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nutrient enrichment caused by in situ fish farms at Eilat, Red Sea is detrimental to coral reproduction. | Recent studies report conflicting results concerning the effects of eutrophication on coral reproduction. The present study examines reproductive effort in the brooding coral Stylophora pistillata exposed to chronic eutrophication caused by in situ fish cages (FC) in the northern Gulf of Eilat (Aqaba). Histological stu... | ['Animals', 'Anthozoa', 'Aquaculture', 'Conservation of Natural Resources', 'Eutrophication', 'Fishes', 'Gametogenesis', 'Histological Techniques', 'Indian Ocean', 'Larva', 'Lipid Metabolism', 'Nitrogen Compounds', 'Phosphorus Compounds', 'Reproduction'] | 15,341,829 | [['B01.050'], ['B01.050.500.308.237'], ['J01.040.168'], ['J01.256', 'N06.230.080'], ['G16.500.285'], ['B01.050.150.900.493'], ['G04.152.650', 'G08.686.784.310'], ['E01.370.225.750', 'E05.200.750'], ['Z01.756.342'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G03.458'], ['D01.625'], ['D01.695'], ['G08.686.784']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Plasma lipoproteins during and after danazol treatment. | Twelve women with pelvic endometriosis were treated with danazol, at a dose of 200 mg three times daily, over a 24-week period. The concentrations of cholesterol and triglycerides were determined in plasma and in the lipoprotein fractions. After only 2 weeks the mean high density lipoprotein (HDL) cholesterol had alrea... | ['Danazol', 'Endometriosis', 'Female', 'Humans', 'Lipoproteins, HDL', 'Lipoproteins, LDL', 'Pregnadienes'] | 6,594,004 | [['D04.210.500.745.432.235'], ['C13.351.500.163'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.432', 'D12.776.521.479'], ['D10.532.515', 'D12.776.521.550'], ['D04.210.500.745.432']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Correction of vascular hypercontractility in spontaneously hypertensive rats using shRNAs-induced delta protein kinase C gene silencing. | Potassium conductance in vascular smooth muscle (VSM) is known to be altered in arterial hypertension. High level of protein kinase C (PKC) activity is a common feature for hypertension of different genesis. The main goal of this study was to investigate the efficacy of the RNA interference (RNAi) technique targeting P... | ['Acetylcholine', 'Animals', 'Genetic Techniques', 'In Vitro Techniques', 'Male', 'Protein Kinase C-delta', 'RNA Interference', 'RNA, Small Interfering', 'Rats', 'Rats, Inbred SHR', 'Vasoconstriction'] | 23,973,649 | [['D02.092.211.111'], ['B01.050'], ['E05.393'], ['E05.481'], ['D08.811.913.696.620.682.700.725.400'], ['G05.308.203.374.790'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.875'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.300', 'B01.050.150.900.649.313.992.635.505.700.400.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Profile of 1,300 admissions to Central Neuropsychiatric Hospital Association Collaborative Research Hospitals. | A collaborative effort to describe patients at admission led to the development of the Central Data Set, a 32-item profile of demographic and clinical variables which was used to sample 1,302 admissions across 10 hospitals in 1982. Weighted estimates indicated that this group of adult patients admitted to CNPHA-member ... | ['Data Collection', 'Hospitals, Psychiatric', 'Humans', 'Medical History Taking', 'Mental Disorders', 'Patient Admission', 'Research', 'Statistics as Topic', 'United States'] | 10,282,441 | [['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.510'], ['F03'], ['E02.760.400.600', 'N02.421.585.400.600'], ['H01.770.644'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830'], ['Z01.107.567.875'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. | Mammalian species differ dramatically in telomere biology. Species larger than 5-10 kg repress somatic telomerase activity and have shorter telomeres, leading to replicative senescence. It has been proposed that evolution of replicative senescence in large-bodied species is an anti-tumour mechanism counteracting increa... | ['Animals', 'Carcinogenesis', 'Cellular Senescence', 'Evolution, Molecular', 'Fibroblasts', 'Genes, Retinoblastoma', 'Genes, p53', 'Genes, ras', 'Humans', 'Mice, Nude', 'Primary Cell Culture', 'Rodentia', 'Skin', 'Telomerase', 'Telomere', 'Telomere Homeostasis', 'Xenograft Model Antitumor Assays'] | 29,335,367 | [['B01.050'], ['C04.697.098', 'C23.550.727.098'], ['G04.043'], ['G05.045.250', 'G16.075.250'], ['A11.329.228'], ['G05.360.340.024.340.375.249.400', 'G05.360.340.024.340.415.400.400'], ['G05.360.340.024.340.375.249.385', 'G05.360.340.024.340.415.400.385'], ['G05.360.340.024.340.375.500.791.550'], ['B01.050.150.900.649.3... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An asymptotic model of particle deposition at an airway bifurcation. | Particle transport and deposition associated with flow over a wedge is investigated as a model for particle transport and flow at the carina of an airway bifurcation during inspiration. Using matched asymptotics, a uniformly valid solution is obtained to represent the high Reynolds number flow over a wedge that conside... | ['Aerosols', 'Biological Transport, Active', 'Humans', 'Hydrodynamics', 'Mathematical Concepts', 'Models, Biological', 'Particle Size', 'Particulate Matter', 'Respiratory Physiological Phenomena', 'Respiratory System', 'Tissue Distribution'] | 22,378,463 | [['D20.280.055', 'D26.255.165.055'], ['G03.143.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.342'], ['G17'], ['E05.599.395'], ['G02.712'], ['D20.633'], ['G09.772'], ['A04'], ['G03.787.917', 'G07.690.725.949']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The reactions of hydropersulfides (RSSH) with myoglobin. | Hydropersulfides are reported to be good biological reductants, superior to thiols and akin to selenols. As such, they have been previously shown to reduce metalloproteins such as ferric myoglobin and ferric cytochrome c to their ferrous forms under conditions where little or no reduction from corresponding thiols is o... | ['Animals', 'Ascorbic Acid', 'Cattle', 'Horses', 'Hydroxylamine', 'Models, Chemical', 'Myoglobin', 'Oxidation-Reduction', 'Oxygen', 'Penicillamine', 'Sulfides'] | 32,360,749 | [['B01.050'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['B01.050.150.900.649.313.500.380.271'], ['B01.050.150.900.649.313.984.235.472'], ['D01.625.062.437'], ['E05.599.495'], ['D12.776.210.500.588', 'D12.776.422.316.940'], ['G02.700', 'G03.295.531'], ['D01.268.185.550', 'D01.362.670'], ['D02.886.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Functional interaction between KChIP1 and GFP-fused Kv4.3L co-expressed in HEK293 cells. | The trafficking and electrophysiological characteristics of Kv4 subfamily are regulated by K+-channel-interacting proteins (KChIPs), which bind to the N-terminus of Kv4. We examined in HEK293 expression system whether the fusion of a green fluorescence protein (GFP) with Kv4.3L at the N-terminus would affect the functi... | ['Calcium Signaling', 'Calcium-Binding Proteins', 'Cell Line', 'DNA, Complementary', 'Electrophysiology', 'Green Fluorescent Proteins', 'Humans', 'Image Processing, Computer-Assisted', 'Immunohistochemistry', 'Indicators and Reagents', 'Kv Channel-Interacting Proteins', 'Luminescent Proteins', 'Microscopy, Confocal', '... | 11,976,919 | [['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['D12.776.157.125'], ['A11.251.210'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['H01.158.344.528', 'H01.158.782.236'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.22... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Detection of mRNA in cultured cells transfected with recombinant DNA by in situ hybridization. | Expression of mRNA in monolayer cells transfected with a series of recombinant DNA was demonstrated by in situ hybridization with biotin- or 32P-labelled probes. Neomycin resistant mRNA stably expressed in pSV2neo transformed cells was positively stained in the cytoplasm of the cells by in situ hybridization with a bio... | ['Animals', 'Cell Line', 'DNA, Recombinant', 'Dogs', 'Nucleic Acid Hybridization', 'RNA, Messenger', 'Transfection'] | 2,073,684 | [['B01.050'], ['A11.251.210'], ['D13.444.308.460'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.393.661', 'G02.111.611'], ['D13.444.735.544'], ['E05.393.350.810', 'G05.728.860']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3-D Imaging Reveals Participation of Donor Islet Schwann Cells and Pericytes in Islet Transplantation and Graft Neurovascular Regeneration. | The primary cells that participate in islet transplantation are the endocrine cells. However, in the islet microenvironment, the endocrine cells are closely associated with the neurovascular tissues consisting of the Schwann cells and pericytes, which form sheaths/barriers at the islet exterior and interior borders. Th... | ['Animals', 'Cell Proliferation', 'Cellular Microenvironment', 'Endothelial Cells', 'Graft Survival', 'Imaging, Three-Dimensional', 'Islets of Langerhans', 'Islets of Langerhans Transplantation', 'Kidney', 'Mice', 'Mice, Inbred C57BL', 'Neovascularization, Physiologic', 'Neurilemma', 'Neurogenesis', 'Pericytes', 'Regen... | 26,137,552 | [['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.366'], ['A11.436.275'], ['G12.875.545.340'], ['E01.370.350.400', 'L01.224.308.410'], ['A03.734.414', 'A06.300.414'], ['E02.095.147.500.250', 'E04.270.550', 'E04.936.225.375'], ['A05.810.453'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Contributions of a specialty clinic for children and adolescents with Down syndrome. | We investigated what added value, if any, a Down syndrome specialty clinic brings to the healthcare needs of children and adolescents with Down syndrome. For this quality improvement study, we performed a retrospective chart review of 105 new patients with Down syndrome, ages 3 and older, seen during the inaugural year... | ['Adolescent', 'Ambulatory Care Facilities', 'Cardiovascular Diseases', 'Child', 'Child, Preschool', 'Down Syndrome', 'Female', 'Humans', 'Hypothyroidism', 'Male', 'Parents', 'Pneumonia', 'Quality Improvement', 'Referral and Consultation', 'Retrospective Studies', 'Skin Diseases', 'Strabismus', 'Young Adult'] | 23,401,090 | [['M01.060.057'], ['N02.278.035'], ['C14'], ['M01.060.406'], ['M01.060.406.448'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.482'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['C01.748.610', 'C08.381.67... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Intracranial Response to Anti-Programmed Death 1 Therapy in a Patient with Metastatic Non-Small Cell Lung Cancer with Leptomeningeal Carcinomatosis. | Central nervous system metastasis in non-small cell lung cancer remains a therapeutic challenge and confers a poor prognosis. Here we describe a patient with lung adenocarcinoma, parenchymal brain metastases, and leptomeningeal carcinomatosis who demonstrated a sustained response to programmed death 1 inhibition combin... | ['Aged', 'Brain Neoplasms', 'Carcinoma, Non-Small-Cell Lung', 'Female', 'Humans', 'Lung Neoplasms', 'Meningeal Carcinomatosis', 'Programmed Cell Death 1 Receptor', 'Treatment Outcome'] | 30,072,392 | [['M01.060.116.100'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.588.614.250.580.150', 'C10.551.240.500... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Drosophila quail, a villin-related protein, bundles actin filaments in apoptotic nurse cells. | Drosophila Quail protein is required for the completion of fast cytoplasm transport from nurse cells to the oocyte, an event critical for the production of viable oocytes. The abundant network of cytoplasmic filamentous actin, established at the onset of fast transport, is absent in quail mutant egg chambers. Previousl... | ['Actin Cytoskeleton', 'Actins', 'Amino Acid Sequence', 'Animals', 'Apoptosis', 'Biological Transport', 'Calcium', 'Carrier Proteins', 'Cloning, Molecular', 'Cytoplasm', 'Drosophila melanogaster', 'Escherichia coli', 'Humans', 'Insect Proteins', 'Microfilament Proteins', 'Molecular Sequence Data', 'Recombinant Fusion P... | 10,572,041 | [['A11.284.430.214.190.750.050'], ['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G04.146.954.035'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157'], ['E05.393.220'], ['A11.284.430.214'], ['B01.050.500.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
State boards of nursing and issues of advanced practice. | Technological advances in today's health care arena and the evolution of the nursing profession have resulted in many questions about scope-of-practice issues. These questions are of a legal nature and frequently must be addressed by the board of nursing in each state. The results of a survey of all state boards of nur... | ['Catheters, Indwelling', 'Humans', 'Legislation, Nursing', 'Licensure, Nursing', 'Professional Practice', 'Specialties, Nursing', 'United States'] | 1,748,910 | [['E07.132.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.615.544'], ['N03.706.110.510.490', 'N05.700.200.450.550'], ['N04.452.758'], ['H02.478.676'], ['Z01.107.567.875']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Thoracocentesis in cardiac surgery patients. | Pleural effusion following cardiac surgery is a common complication that sometimes requires invasive treatment. Conventional methods for evacuation include needle aspiration and chest tube insertion. We present an effective, easy and potentially time-saving method of thoracocentesis, using a single-lumen central venous... | ['Cardiac Surgical Procedures', 'Central Venous Catheters', 'Humans', 'Paracentesis', 'Pleural Effusion'] | 25,901,010 | [['E04.100.376', 'E04.928.220'], ['E07.132.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.998.329', 'E02.309.805', 'E02.800.550', 'E04.237.667', 'E04.665.600', 'E05.200.998.329'], ['C08.528.652']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fracture toughness of denture base acrylics. | Two types of fracture toughness specimen, the tapered cleavage (TC) and single edge notch (SEN), are compared. Their reproducibility, accuracy, and ease of preparation are investigated. The fracture toughness of four types of acrylic resin, heat cured, autopolymerized, injection molded, and high impact resistant, has b... | ['Acrylic Resins', 'Dental Stress Analysis', 'Denture Bases', 'Elasticity', 'Methylmethacrylates', 'Polymers', 'Surface Properties', 'Tensile Strength'] | 7,400,192 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['E06.308'], ['E06.780.346.760.281', 'E07.695.190.200.200'], ['G01.374.590'], ['D02.241.081.069.800.550', 'D05.750.716.822.111.650.605', 'D25.720.716.822.111.650.605', 'J01.637.051.720.716.822.111.650.605'], ['D05.750', 'D25.720', 'J01.637.... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
á2 | BACKGROUND: Xylazine is an á2 adrenoceptor agonist that is extensively used in veterinary medicine and animal experimentation procedures to produce analgesia, sedation and muscle relaxation without causing general anesthesia. Considering the lack of knowledge of the mechanisms involved in peripheral antinociception ind... | ['Adrenergic alpha-2 Receptor Agonists', 'Analgesics', 'Animals', 'Arachidonic Acids', 'Chromatography, Liquid', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Endocannabinoids', 'Hyperalgesia', 'Male', 'Mass Spectrometry', 'Polyunsaturated Alkamides', 'Rats', 'Rats, Wistar', 'Receptor, Cannabinoid, CB1... | 32,016,857 | [['D27.505.519.625.050.100.100.200', 'D27.505.696.577.050.100.100.200'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['B01.050'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['E05.196.181.400'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['D10.251.265'], ['C10.597... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Utilization of initial chemotherapy for newly diagnosed acute myeloid leukemia in the United States. | The use of chemotherapy in patients with acute myeloid leukemia (AML) is associated with survival benefits and alleviation of symptoms related to AML. Prior studies have demonstrated a lower receipt of chemotherapy with increasing age and comorbidities. We hypothesized that socioeconomic and health system factors also ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Databases, Factual', 'Female', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'United States'] | 29,880,697 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275'], ['M01.060.116.630'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
C-terminus of progranulin interacts with the beta-propeller region of sortilin to regulate progranulin trafficking. | Progranulin haplo-insufficiency is a main cause of frontotemporal lobar degeneration (FTLD) with TDP-43 aggregates. Previous studies have shown that sortilin regulates progranulin trafficking and is a main determinant of progranulin level in the brain. In this study, we mapped the binding site between progranulin and s... | ['Adaptor Proteins, Vesicular Transport', 'Amino Acid Sequence', 'Animals', 'Blotting, Western', 'Cell Line', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Models, Molecular', 'Molecular Sequence Data', 'Progranulins', 'Protein Binding', 'Protein Transport', 'Sequence Homology, Amino Acid'] | 21,698,296 | [['D12.776.543.990.150'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276', 'D12.776.467', 'D23.529'], ['E05.599.595'], ['L01.453.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Use of the neo-adjuvant exemestane in post-menopausal estrogen receptor-positive breast cancer: a randomized phase II trial (PTEX46) to investigate the optimal duration of preoperative endocrine therapy. | PURPOSE: The optimal treatment duration time and the causal relationship between neoadjuvant endocrine therapy and clinical response are not clear. Therefore, we conducted the present study to investigate the potential benefits of neoadjuvant exemestane therapy with the goal of identifying the optimal treatment duratio... | ['Aged', 'Aged, 80 and over', 'Androstadienes', 'Antineoplastic Agents', 'Breast Neoplasms', 'Carcinoma', 'Chemotherapy, Adjuvant', 'Drug Administration Schedule', 'Female', 'Humans', 'Mastectomy, Segmental', 'Middle Aged', 'Neoadjuvant Therapy', 'Postmenopause', 'Receptors, Estrogen', 'Time Factors'] | 23,587,451 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D04.210.500.054.079.129'], ['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200'], ['E02.186.170', 'E02.319.170'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.466.701'], ['M01.060.116.630'], ['E02.186.450'], ['G08.686.157... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genetic characterization of Toxoplasma gondii from cats in Yunnan Province, Southwestern China. | BACKGROUND: Cats are the definitive hosts of Toxoplasma gondii. The distribution of genetic diversity of T. gondii in cats is of importance to understand the transmission of this parasite. The objective of this study was to genetically characterize T. gondii isolates from cats in Yunnan province, southwestern China.MET... | ['Animals', 'Cat Diseases', 'Cats', 'China', 'DNA, Protozoan', 'Genotype', 'Prevalence', 'Toxoplasma', 'Toxoplasmosis, Animal'] | 24,725,959 | [['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['Z01.252.474.164'], ['D13.444.308.442'], ['G05.380'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['B01.043.075.189.250.750.800'], ['C01.610.701.688.817', 'C01.610.752.250.8... | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
RNA recognition by the DNA end-binding Ku heterodimer. | Most nucleic acid-binding proteins selectively bind either DNA or RNA, but not both nucleic acids. The Saccharomyces cerevisiae Ku heterodimer is unusual in that it has two very different biologically relevant binding modes: (1) Ku is a sequence-nonspecific double-stranded DNA end-binding protein with prominent roles i... | ['Base Sequence', 'Binding Sites', 'CME-Carbodiimide', 'Cell Nucleus', 'DNA Footprinting', 'DNA-Binding Proteins', 'Electrophoresis, Polyacrylamide Gel', 'Inverted Repeat Sequences', 'Mutation', 'Nucleic Acid Conformation', 'Nucleotide Motifs', 'Phosphorothioate Oligonucleotides', 'Protein Interaction Mapping', 'RNA', ... | 23,610,127 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D02.491.203.340'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E05.393.300'], ['D12.776.260'], ['E05.196.401.402', 'E05.301.300.319'], ['G02.111.570.080.708.800.325', 'G05.360.080.708.800.325'], ['G05.365.590'], ['G02.111.570.8... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparative analysis of circulating tumor DNA stability In K3 | OBJECTIVES: Optimal conditions for blood collection for circulating tumor DNA (ctDNA) are still being developed. Although both Streck and EDTA tubes are commonly used, their ability to stabilize ctDNA as a function of time and temperature post-collection has not been thoroughly studied. Additionally, the potential util... | ['DNA, Neoplasm', 'Edetic Acid', 'Humans', 'Specimen Handling'] | 27,129,799 | [['D13.444.308.425'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.998', 'E05.200.998']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Norcantharidin modulates development of dendritic cells and prolongs skin allograft survival. | BACKGROUND: To examine the effects of norcantharidin (NCTD) on development of human myeloid dendritic cells (DCs) in vitro and in skin allograft transplantation in vivo.METHODS: Human CD14(+) monocytes were isolated and triggered differentiation and maturation toward myeloid DCs with and without NCTD. The cell morpholo... | ['Animals', 'Bridged Bicyclo Compounds, Heterocyclic', 'Dendritic Cells', 'Graft Rejection', 'Graft Survival', 'Humans', 'Immunosuppressive Agents', 'Interleukin-10', 'Interleukin-12', 'Lymphocyte Activation', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Skin Transplantation', 'Transplantation, Homolog... | 21,876,479 | [['B01.050'], ['D03.605.084'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['G12.875.545.328'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['D12.644.276.374.465.51... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A software to digital image processing to be used in the voxel phantom development. | Anthropomorphic models used in computational dosimetry, also denominated phantoms, are based on digital images recorded from scanning of real people by Computed Tomography (CT) or Magnetic Resonance Imaging (MRI). The voxel phantom construction requests computational processing for transformations of image formats, to ... | ['Algorithms', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Models, Anatomic', 'Phantoms, Imaging', 'Software', 'Tomography, X-Ray Computed'] | 20,003,807 | [['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129'], ['E07.671'], ['L01.224.900'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Co-amplification of erbB2, topoisomerase II alpha and retinoic acid receptor alpha genes in breast cancer and allelic loss at topoisomerase I on chromosome 20. | The DNA topoisomerase enzymes are targets for the cytotoxic effects of a number of anticancer agents termed topoisomerase inhibitors. We have analysed breast cancer biopsy specimens for genetic alterations at and around topoisomerase loci in order to obtain molecular insight into factors which may determine how tumours... | ['Aged', 'Aged, 80 and over', 'Alleles', 'Breast Neoplasms', 'Chromosomes, Human, Pair 17', 'DNA Topoisomerases, Type II', 'DNA, Neoplasm', 'ErbB Receptors', 'Female', 'Gene Amplification', 'Humans', 'Middle Aged', 'Proto-Oncogene Proteins', 'Receptor, ErbB-2', 'Receptors, Retinoic Acid', 'Tretinoin'] | 8,104,440 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['C04.588.180', 'C17.800.090.500'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['D08.811.399.403.741'], ['D13.444.308.425'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'],... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sequential monitoring of beach litter using webcams. | This study attempts to establish a system for the sequential monitoring of beach litter using webcams placed at the Ookushi beach, Goto Islands, Japan, to establish the temporal variability in the quantities of beach litter every 90 min over a one and a half year period. The time series of the quantities of beach litte... | ['Air Movements', 'Bathing Beaches', 'Environmental Monitoring', 'Environmental Pollutants', 'Garbage', 'Geography', 'Humans', 'Internet', 'Japan', 'Photography', 'Time Factors', 'Water Movements', 'Wind'] | 20,392,465 | [['G16.500.175.249', 'G16.500.275.063.725.154', 'N06.230.300.100.150.185'], ['J03.925.080'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['N06.850.860.510.900.600.400'], ['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['Z01.252.474.463', 'Z01.639.595'], ['E01.... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
Inhibition of thymidine phosphorylase expression by Hsp90 inhibitor potentiates the cytotoxic effect of salinomycin in human non-small-cell lung cancer cells. | Salinomycin is a polyether ionophore antibiotic having anti-tumorigenic property in various types of cancer. Elevated thymidine phosphorylase (TP) levels, a key enzyme in the pyrimidine nucleoside salvage pathway, are associated with an aggressive disease phenotype and poor prognoses. Heat shock protein 90 (Hsp90) is a... | ['A549 Cells', 'Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'Cytotoxins', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Gene Expression Regulation, Enzymologic', 'HSP90 Heat-Shock Proteins', 'Humans', 'Lung Neoplasms', 'Pyrans', 'Thymidine Phosphorylase'] | 30,796,972 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['D27.888.569.213'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.389'], ['G05.308.320'], ['D12.776.580.216.380'], ['B01.050.150.900.649.31... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extracellular calcium and human isolated airway muscle: ionophore A23187 induced contraction. | In order to investigate the role played by extracellular calcium mobilization in activating human airway contraction, we studied the effects of A23187, a calcium ionophore, in human isolated bronchial spiral strips. In this preparation, ionophore induced a concentration dependent contraction from 10(-7) M to 10(-5) M w... | ['Calcimycin', 'Calcium', 'Carbachol', 'Histamine', 'Humans', 'In Vitro Techniques', 'Muscle Contraction', 'Muscle, Smooth', 'Respiratory Physiological Phenomena', 'Respiratory System'] | 3,124,236 | [['D03.633.100.221.173'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['G11.427.494'], ['A02.633.570', 'A10.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nine-year progression of untreated pulmonary Mycobacterium szulgai infection. | A 58-year-old man was seen with complaints of fevers, night sweats, weight loss, and multiple bilateral cavitary lung lesions. Mycobacterium szulgai with nearly identical antibiograms grew from separate sputum specimens 9 years apart. He was treated with a combination of clarithromycin and ethambutol with clinical, mic... | ['Antitubercular Agents', 'Clarithromycin', 'Delayed Diagnosis', 'Disease Progression', 'Drug Therapy, Combination', 'Ethambutol', 'Humans', 'Lung Diseases', 'Male', 'Middle Aged', 'Mycobacterium Infections, Nontuberculous', 'Nontuberculous Mycobacteria'] | 20,622,732 | [['D27.505.954.122.085.255'], ['D02.540.576.500.992.100'], ['E01.110', 'E02.760.273', 'N02.421.585.273'], ['C23.550.291.656'], ['E02.319.310'], ['D02.092.782.258.368.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['M01.060.116.630'], ['C01.150.252.410.040.552.475'], ['B03.510.024.962.500.720', 'B0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Properties of recombinant Staphylococcus haemolyticus cystathionine beta-lyase (metC) and its potential role in the generation of volatile thiols in axillary malodor. | Enzymes implicated in cysteine and methionine metabolism such as cystathionine beta-lyase (CBL; EC 4.4.1.8), a pyridoxal-5'-phosphate (PLP)-dependent carbon-sulfur lyase, have been shown to play a central role in the generation of sulfur compounds. This work describes the unprecedented cloning and characterization of t... | ['Amino Acid Sequence', 'Cystathionine', 'Cysteine', 'Humans', 'Lyases', 'Male', 'Methionine', 'Phylogeny', 'Recombinant Proteins', 'Staphylococcus haemolyticus', 'Substrate Specificity', 'Sulfhydryl Compounds', 'Sweat'] | 19,035,565 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D02.886.030.175', 'D12.125.095.307', 'D12.125.119.307', 'D12.125.166.175'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.520'], ['D02.886.030.676', 'D12.125.142.557', 'D12.125.154.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1. | A novel widely expressed homologue of the VAV oncogene, VAV2 (53% identical residues), has been identified within the critical region for the tuberous sclerosis gene, TSC1, on human chromosome 9q34. By Southern blot analysis, analysis of allele-specific transcription, and direct sequencing of the VAV2 mRNA/cDNA from pa... | ['Alleles', 'Amino Acid Sequence', 'Base Sequence', 'Cell Cycle Proteins', 'Chromosome Mapping', 'Chromosomes, Human, Pair 9', 'DNA Mutational Analysis', 'DNA, Complementary', 'Humans', 'Molecular Sequence Data', 'Oncogene Proteins', 'Oncogenes', 'Organ Specificity', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins ... | 7,762,982 | [['G05.360.340.024.340.030'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.167'], ['E05.393.183'], ['A11.284.187.520.300.325.345', 'G05.360.162.520.300.325.345'], ['E05.393.760.700.300'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A morphological and electrophysiological study of nigrotectal pathway in the rat. | After horseradish peroxidase injections in the superior colliculus of the rat, labelled cells were found in the pars reticulata of the substantia nigra. Nigrotectal cells are organized in a band beginning in the ventromedial area of the rostral part of pars reticulata, while at caudal levels they occupy a more lateral ... | ['Animals', 'Electric Stimulation', 'Electrophysiology', 'Neural Pathways', 'Rats', 'Substantia Nigra', 'Superior Colliculi'] | 7,244,326 | [['B01.050'], ['E05.723.402'], ['H01.158.344.528', 'H01.158.782.236'], ['A08.612'], ['B01.050.150.900.649.313.992.635.505.700'], ['A08.186.211.132.659.413.656'], ['A08.186.211.132.659.800.816']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A cope rearrangement in the reaction catalyzed by dimethylallyltryptophan synthase? | The enzyme dimethylallyltryptophan synthase catalyzes the "normal" prenylation of Trp at C-4 in the first step of ergot alkaloid biosynthesis. The Lys174Ala mutant is found to produce a hexahydropyrroloindole alkaloid that is "reverse-prenylated" at C-3 as its major product. This is interpreted as evidence in support o... | ['Alkyl and Aryl Transferases', 'Aspergillus fumigatus', 'Indole Alkaloids', 'Mutagenesis, Site-Directed', 'Prenylation'] | 21,766,851 | [['D08.811.913.225'], ['B01.300.381.081.295'], ['D03.132.436', 'D03.633.100.473.402', 'D03.633.100.496.500.500'], ['E05.393.420.601.575'], ['G02.111.672', 'G03.804']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endocarditis associated with disseminated group B streptococcal infection. | Endocarditis due to group B streptococci occurred in two men associated with meningitis in one and septic arthritis in the other. Therapy with penicillin failed in the first patient necessitating aortic valve replacement. Clindamycin therapy was not curative in the second and the patient responded to a four-week course... | ['Aged', 'Aortic Valve', 'Endocarditis, Bacterial', 'Heart Valve Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Streptococcal Infections', 'Streptococcus agalactiae', 'Vancomycin'] | 341,708 | [['M01.060.116.100'], ['A07.541.510.110'], ['C01.150.252.245', 'C01.190.249', 'C14.260.249', 'C14.280.282.407'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C01.150.252.410.890'], ['B03.353.750.737.872.100', 'B03.510.400.800.872.100', 'B03.510.550.737.872.100'], ['D09.400.42... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Doctors' perspectives and practices regarding epilepsy. | OBJECTIVE: The main aim of this study was to evaluate the knowledge, management practices and attitudes towards people with epilepsy (PWE) by a group of general practitioners (GP) and pediatrician (PD) residents.METHODS: A cross-sectional study was carried out in three training hospitals, and had been selected 31 GP an... | ['Attitude of Health Personnel', 'Confidence Intervals', 'Cross-Sectional Studies', 'Epilepsy', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Internship and Residency', 'Male', 'Pediatrics', 'Physicians, Family', "Practice Patterns, Physicians'", 'Surveys and Questionnaires'] | 10,849,618 | [['F01.100.050', 'N05.300.100'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C10.228.140.490'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.35... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Monte Carlo simulation of linac irradiation with dynamic wedges. | This study aims to simulate the dose distributions of LINAC with dynamic wedges (DWs) under various field sizes and wedge angles by the BEAMnrc code with DYNJAWS component module. These were compared with those calculated by the treatment planning system (TPS) and the measured data. All percentage depth doses (PDDs) we... | ['Humans', 'Monte Carlo Method', 'Particle Accelerators', 'Photons', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Intensity-Modulated', 'Software'] | 25,004,937 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E07.710.680'], ['G01.249.705', 'G01.358.500.505.650.782', 'G01.590.540.782', 'G01.750.250.650.782', 'G01.750.770.578.782'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission. | Phorbol esters, activators of protein kinase C (PKC), have been shown to enhance synaptic transmission. One potential downstream target of PKC in the presynaptic terminal is the soluble N-ethylmaleimide sensitive factor (NSF) attachment protein receptor (SNARE) SNAP-25, which has a PKC phosphorylation site in its C-ter... | ['Animals', 'Hippocampus', 'Membrane Proteins', 'Mice', 'Mutation', 'Nerve Tissue Proteins', 'Phorbol Esters', 'Phosphorylation', 'Serine', 'Synaptic Transmission', 'Synaptosomal-Associated Protein 25', 'Up-Regulation'] | 14,529,723 | [['B01.050'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D12.776.543'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.365.590'], ['D12.776.631'], ['D02.455.849.291.500.510'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D12.125.154.800'], ['G02.111.820.850', 'G04.835.850', 'G07.265.880', 'G11.56... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Carbonic anhydrase activity in myelin fractions from rat optic nerves. | The carbonic anhydrase activity of myelin fractions isolated from the optic nerves of adult and immature (20-day-old) rats was examined. The specific activity in both total homogenate and myelin fractions was about 2-fold higher in adult than in immature animals and at both ages, the activity in the homogenate was high... | ['Aging', 'Animals', 'Carbonic Anhydrases', 'Myelin Sheath', 'Optic Nerve', 'Rats'] | 111,175 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fifth toenail clinical response to systemic antifungal therapy is not a marker of successful therapy for other toenails with onychomycosis. | BACKGROUND: Onychodystrophy is a major manifestation of onychomycosis. However, nail trauma may also result in onychodystrophy. The fifth toenail, due to its location, suffers repeated friction/pressure trauma from shoes.OBJECTIVE: To test the hypothesis that treatment failure of fifth toenail onychomycosis is not a ma... | ['Antifungal Agents', 'Foot Dermatoses', 'Humans', 'Nails', 'Naphthalenes', 'Onychomycosis', 'Pressure', 'Shoes', 'Terbinafine', 'Treatment Outcome'] | 17,062,030 | [['D27.505.954.122.136'], ['C17.800.321.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A17.600'], ['D02.455.426.559.847.638', 'D04.615.638'], ['C01.150.703.302.720.550', 'C01.800.200.720.550', 'C17.800.529.550', 'C17.800.838.208.883.458'], ['G01.374.715'], ['J01.637.215.800'], ['D02.455.426.559.847.638.953',... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Pulmonary hemodynamics and tissue damage after one lung infusion of Pseudomonas aeruginosa in sheep. | The relative roles of hematogenous mediators and direct bacterial toxicity due to phagocytosis by pulmonary intravascular macrophages were determined by selective bacterial infusion into the left pulmonary artery and comparison of right and left lungs at 24 h. Chronically instrumented sheep received 15-min pulmonary ar... | ['Animals', 'Female', 'Hemodynamics', 'Infusions, Intra-Arterial', 'Lung', 'Lung Injury', 'Neutrophils', 'Phagocytosis', 'Pseudomonas aeruginosa', 'Pulmonary Artery', 'Pulmonary Circulation', 'Sheep'] | 1,592,731 | [['B01.050'], ['G09.330.380'], ['E02.319.267.510.520'], ['A04.411'], ['C08.381.520', 'C26.891.554'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583', 'A15.382.490.315.583', 'A15.382.680.689'], ['G04.417.350', 'G09.188.665', 'G12.450.564.809', 'G12.688'], ['B03.440.400.425.625.625.100... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation of monoclonal antibodies to hirudin and hirudin peptides. A method for studying the hirudin--thrombin interaction. | A panel of four monoclonal antibodies was obtained against hirudin, a potent and specific inhibitor of thrombin, by immunizing three groups of mice with protein conjugates made of recombinant desulfatohirudin (group I) or two synthetic peptides representing the C-terminal sequences 40-65 (group II) and 52-65 (group III... | ['Animals', 'Antibodies, Monoclonal', 'Antigen-Antibody Complex', 'Binding Sites', 'Binding Sites, Antibody', 'Blood Coagulation Tests', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Hirudins', 'Mice', 'Peptide Fragments', 'Recombinant Proteins', 'Serine Endopeptidases', 'Thrombin'] | 1,690,651 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['G02.111.570.120'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte. | Human leukocyte cDNA library was screened to isolate cDNA clones coding for hepatocyte growth factor using cDNA from human liver as a probe. Nucleotide and deduced amino acid sequences were analyzed for two of four clones obtained. One of them contained an open reading frame coding for a polypeptide chain of 728 amino ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Division', 'Cell Line', 'Cloning, Molecular', 'DNA', 'Gene Library', 'Growth Substances', 'Hepatocyte Growth Factor', 'Humans', 'Leukocytes', 'Liver', 'Molecular Sequence Data', 'Oligonucleotide Probes', 'Restriction Mapping', 'Transfection'] | 2,145,836 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['E05.393.220'], ['D13.444.308'], ['G05.360.325'], ['D27.505.696.377'], ['D12.644.276.374.420', 'D12.776.467.374... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Quantitative assessment of the accuracy of dose calculation using pencil beam and Monte Carlo algorithms and requirements for clinical quality assurance. | To compare the doses calculated using the BrainLAB pencil beam (PB) and Monte Carlo (MC) algorithms for tumors located in various sites including the lung and evaluate quality assurance procedures required for the verification of the accuracy of dose calculation. The dose-calculation accuracy of PB and MC was also asse... | ['Algorithms', 'Humans', 'Monte Carlo Method', 'Neoplasms', 'Quality Assurance, Health Care', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted'] | 23,558,145 | [['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['C04'], ['N04.761.700', 'N05.700'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes. | The relative specificities of members of the G alpha q family of GTP-binding proteins were tested for their ability to activate different phosphoinositide-specific phospholipase C (PI-PLC) beta isozymes. Cos-7 cells were transfected with cDNA corresponding to G alpha q, G alpha 11, G alpha 14, and G alpha 16. Most of t... | ['Amino Acid Sequence', 'Animals', 'Antibodies', 'Cell Line', 'Cell Membrane', 'Enzyme Activation', 'GTP-Binding Proteins', "Guanosine 5'-O-(3-Thiotriphosphate)", 'Isoenzymes', 'Kinetics', 'Macromolecular Substances', 'Molecular Sequence Data', 'Multigene Family', 'Peptides', 'Phosphatidylinositol Diacylglycerol-Lyase'... | 1,322,889 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A11.251.210'], ['A11.284.149'], ['G02.111.263', 'G03.328'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['D02.886.765.380', 'D13.695.667.454.504.380', 'D13.695.827.426.504.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Single breath nitrogen washout in pulmonary sarcoidosis. | In 35 patients with pulmonary sarcoidosis we explored the utility of single breath nitrogen washout as a means for detecting abnormalities in airway function and intrapulmonary distribution of air. Closing volume/vital capacity ratio (CV/VC) was 21% (predicted 12.5%) in patients with only hilar adenopathy (stage I). CV... | ['Adult', 'Female', 'Forced Expiratory Volume', 'Functional Residual Capacity', 'Humans', 'Lung Diseases', 'Male', 'Middle Aged', 'Nitrogen', 'Pulmonary Diffusing Capacity', 'Respiration', 'Respiratory Function Tests', 'Sarcoidosis', 'Smoking'] | 7,111,863 | [['M01.060.116'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['E01.370.386.700.485.750.275', 'G09.772.850.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['M01.060.116.630'], ['D01.268.604', 'D01.362.625'], ['E01.370.386.700.650.650', 'G09.772.600'], ['G09.772.705'], ['E01.370.386.700'], ['C15... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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