Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Cytolytic virus activation therapy for Epstein-Barr virus-driven tumors. | PURPOSE: Nasopharyngeal carcinoma (NPC) is causally linked to Epstein-Barr virus (EBV) infection. Because all tumor cells carry EBV, the virus itself is a potential target for therapy. In these tumor cells, EBV hides in a latent state and expresses only a few non-immunogenic proteins for EBV maintenance and contributes... | ['Antibodies, Viral', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma', 'Cell Line, Tumor', 'DNA, Viral', 'Deoxycytidine', 'Dose-Response Relationship, Drug', 'Female', 'Herpesvirus 4, Human', 'Humans', 'Immunoglobulin G', 'Male', 'Middle Aged', 'Nasopharyngeal Carcinoma', 'Nasopharyngeal Neoplasms', 'Neop... | 22,761,471 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200'], ['A11.251.210.190', 'A11.251.860.180'], ['D13.444.308.568'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['G07.690.77... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effectiveness of tipranavir versus darunavir as a salvage therapy in HIV-1 treatment-experienced patients. | INTRODUCTION: Although both tipranavir (TPV) and darunavir (DRV) represent important options for the management of patients with multi-protease inhibitor (PI)-resistant human immunodeficiency virus (HIV), currently there are no studies comparing the effectiveness and safety of these two drugs in the Mexican population.... | ['Adult', 'Anti-HIV Agents', 'Cohort Studies', 'Darunavir', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Male', 'Mexico', 'Middle Aged', 'Prospective Studies', 'Pyridines', 'Pyrones', 'Salvage Therapy', 'Sulfonamides', 'Treatment Outcome', 'Viral Load', 'Young Adult'] | 27,694,731 | [['M01.060.116'], ['D27.505.954.122.388.077.088'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D02.065.884.438', 'D02.241.081.251.222', 'D02.886.590.700.400', 'D03.383.312.303'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.40... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Teleoperator performance with varying force and visual feedback. | An experimental study was conducted to determine the effects of various forms of visual and force feedback on human performance for several "peg-in-hole"-type telemanipulation tasks. Each of six human test subjects used a master/slave manipulator during two experimental sessions. In one session the subjects performed t... | ['Artificial Intelligence', 'Computer Graphics', 'Computer Simulation', 'Feedback', 'Humans', 'Male', 'Reference Values', 'Task Performance and Analysis', 'User-Computer Interface', 'Video Recording'] | 8,026,837 | [['G17.035.250', 'L01.224.050.375'], ['L01.224.108', 'L01.296.110'], ['L01.224.160'], ['L01.906.394.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.810'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['L01.224.900.910'], ['L01.280.960']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nuclear DNA sequence specific to Leishmania (Viannia) subgenus: a molecular marker for species identification. | As shown by RFLP analysis, there is a high variability in the beta-tubulin gene region of Leishmania sp. Such variability has been used in the identification of these parasites, establishing differences between subgenera of New World Leishmania. We have found a region of 500 bp (beta500) upstream of the coding region o... | ['Animals', 'Base Sequence', 'Blotting, Southern', 'DNA, Intergenic', 'DNA, Protozoan', 'Genetic Markers', 'Leishmania', 'Polymerase Chain Reaction', 'Species Specificity', 'Tandem Repeat Sequences', 'Tubulin'] | 11,315,173 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D13.444.308.324', 'G05.360.340.024.220'], ['D13.444.308.442'], ['D23.101.387', 'G05.695.450'], ['B01.268.475.868.488'], ['E05.393.620.500'], ['G16.824'], ['G02.111.570.080.708.800', 'G05.360... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Severity of Psychiatric Disorders and Dental Health Among Psychiatric Outpatients in Jerusalem, Israel. | The association between severity of psychiatric disorder and dental disease has not been adequately studied. The aim of the present study was to examine the level of dental caries morbidity and the association with Severe Mental Illness (SMI) and mild/moderate psychiatric disorders. The population sample included patie... | ['Humans', 'Israel', 'Mental Disorders', 'Oral Health', 'Outpatients', 'Severity of Illness Index'] | 26,431,416 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375'], ['F03'], ['N01.400.535'], ['M01.643.630'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500']] | ['Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Bidentate palladium(II) chelation by the common aldoses. | The [Pd(II){(R,R)-chxn}(OH)(2)] reagent (chxn=1,2-diaminocyclohexane) is introduced as a metal probe for the detection of the bidentate chelating sites of a glycose. Two moles of hydroxide per mole palladium support double deprotonation of potentially chelating diol functions at a glycose's backbone. The individual che... | ['Binding Sites', 'Chelating Agents', 'Ethylenediamines', 'Ligands', 'Monosaccharides', 'Organometallic Compounds', 'Palladium', 'Stereoisomerism', 'Water'] | 19,508,913 | [['G02.111.570.120'], ['D27.505.519.914.500', 'D27.720.832.500'], ['D02.092.782.258.368'], ['D27.720.470.480'], ['D09.947.875'], ['D02.691'], ['D01.268.556.680', 'D01.268.956.718', 'D01.552.544.680'], ['G02.607.445.682'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychosomatic subdecompensation. | The ego of a psychosomatic patient enters the relations with the external world in a very archaic way. In new traumatic situations such a personality structure possesses a very poor repertoire of adaptation mechanisms. Owing to the lack of intrapsychic elaboration of the trauma, the conflict is solved in an "interperso... | ['Adult', 'Asthma', 'Conflict, Psychological', 'Humans', 'Male', 'Psychophysiologic Disorders'] | 2,626,967 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['F01.658.209'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.700']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Psychoanalysis, psychoanalytic psychotherapy and supportive psychotherapy: contemporary controversies. | The author explores the controversies involving psychoanalytic psychotherapy from conceptual, clinical and educational perspectives. He proposes an integrated concept of psychoanalytic modalities of treatment, and their subdivision into standard psychoanalysis, psychoanalytic psychotherapy and psychoanalytically based ... | ['Humans', 'Psychoanalysis', 'Psychoanalytic Therapy'] | 10,669,960 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.096.544.779'], ['F04.754.709']] | ['Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative elimination of dimethyl disulfide by maifanite and ceramic-packed biotrickling filters and their response to microbial community. | Unpleasant odor emissions have traditionally occupied an important role in environmental concern. In this paper, twin biotrickling filters (BTFs) packed with different packing materials, seeded with Bacillus cereus GIGAN2, were successfully constructed to purify gaseous dimethyl disulfide (DMDS). The maifanite-packed B... | ['Bacillus', 'Biodegradation, Environmental', 'Bioreactors', 'Ceramics', 'Denaturing Gradient Gel Electrophoresis', 'Disulfides', 'Filtration', 'Polymerase Chain Reaction', 'Silicates', 'Time Factors'] | 26,702,514 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['E07.115', 'J01.897.120.115'], ['J01.637.153'], ['E05.196.401.402.117', 'E05.301.300.319.201'], ['D01.248.497.158.874.390', 'D01.875.350.850.... | ['Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Autoradiographic analysis of [3H]dopamine and [3H]dopa uptake in the turtle olfactory bulb. | Uptake and retention of exogenous tritiated dopamine and L-dopa was observed within turtle olfactory bulb slices. In the more superficial layers, periglomerular and superficial tufted cells, as well as their processes, and intraglomerular dendrites were recognized as labeled. Within the deeper part of the bulb, some la... | ['Animals', 'Autoradiography', 'Dihydroxyphenylalanine', 'Dopamine', 'Olfactory Bulb', 'Tritium', 'Turtles'] | 6,408,497 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['D02.092.311.200', 'D02.455.426.559.389.657.166.175.200', 'D12.125.072.050.685.400', 'D12.125.072.050.875.130'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['A08.186.211.200.885.388'], ['D01.268.406.875', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is There a Trade-off Between Quality and Profitability in United States Nursing Homes? | Nursing home residents across the United States rely on quality care and effective services. Nursing homes provide skilled nurses and nursing aides who can provide services 24 hours a day for individuals who could not perform these tasks for themselves. Not-for-profit (NFP) versus for-profit (FP) nursing homes have bee... | ['Commerce', 'Health Facilities, Proprietary', 'Humans', 'Nursing Homes', 'Quality of Health Care', 'United States'] | 28,383,313 | [['J01.219'], ['N02.278.215'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.825.610'], ['N04.761', 'N05.715'], ['Z01.107.567.875']] | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells. | The cadherins are a family of transmembrane glycoproteins responsible for calcium-dependent cell-cell adhesion. This adhesion is mediated by a group of cytoplasmic proteins, the catenins, which act inside the cell to couple the cadherin molecule to the microfilament cytoskeleton. Dysfunction of E-cadherin-dependent cel... | ['Cadherins', 'Cell Adhesion', 'Cytoskeletal Proteins', 'Gene Deletion', 'Humans', 'Male', 'Molecular Weight', 'Precipitin Tests', 'Prostatic Neoplasms', 'RNA, Messenger', 'Tumor Cells, Cultured', 'alpha Catenin'] | 8,339,265 | [['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['G04.022'], ['D12.776.220'], ['G05.365.590.762.320', 'G05.558.800.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.494'], ['E01.370.225.812.735.645', 'E05.196.150.639.500', 'E05.200.812.735.645', 'E05.478.594.760.645', 'E05.47... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced hydroxychavicol-induced cytotoxic effects in glutathione-depleted HepG2 cells. | Hydroxychavicol (HC) is the major safrole urinary metabolite in rats and humans. The cytotoxic potential of HC in metabolically competent cells has yet to be studied. HC alone was slightly toxic to HepG2 cells. However, the cytotoxicity increased significantly (P<0.05) when HepG2 cells were pretreated with buthionine s... | ["8-Hydroxy-2'-Deoxyguanosine", 'Acetylcysteine', 'Antimetabolites, Antineoplastic', 'Apoptosis', 'Buthionine Sulfoximine', 'Catalase', 'Cell Survival', 'DNA', 'DNA Fragmentation', 'Deoxyguanosine', 'Dose-Response Relationship, Drug', 'Electrons', 'Eugenol', 'Free Radical Scavengers', 'Glutathione', 'Humans', 'Liver Ne... | 10,814,876 | [['D03.633.100.759.590.454.240.500', 'D13.570.230.360.500', 'D13.570.583.454.240.500'], ['D02.886.030.230.259', 'D12.125.166.230.259'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['G04.146.954.035'], ['D02.886.030.676.620.125', 'D12.125.166.676.620.125'], ['D08.811.682.732.332'], ['G04.346']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Orals in the bundle: a policy framework. | Oral prescription drugs for treatment of bone and mineral disorders (phosphate binders and calcimimetics) in patients undergoing dialysis (i.e., those with ESRD) will be integrated into the Medicare Part B ESRD bundled payment system in 2016. Payment will be denied under Medicare Part D. Integrating Part D drugs into P... | ['Administration, Oral', 'Calcimimetic Agents', 'Chelating Agents', 'Drug Costs', 'Health Expenditures', 'Health Policy', 'Humans', 'Insurance, Health, Reimbursement', 'Insurance, Pharmaceutical Services', 'Kidney Failure, Chronic', 'Medicare Part B', 'Medicare Part D', 'Phosphates', 'Policy Making', 'Prescription Drug... | 23,599,409 | [['E02.319.267.100'], ['D06.347.230', 'D27.505.696.399.450.230'], ['D27.505.519.914.500', 'D27.720.832.500'], ['N03.219.151.400.350', 'N05.300.375.300'], ['N03.219.151.450', 'N05.300.385'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro. | Three sequences in the vicinity of poly (A) addition sites are conserved among vertebrate mRNAs. We analyze the effects of single base changes in each position of AAUAAA and in the nucleotide to which poly (A) is added on 3' end formation in vitro. All 18 possible single base changes of the AAUAAA sequence greatly redu... | ['Base Sequence', 'Molecular Sequence Data', 'Mutation', 'Poly A', 'RNA, Messenger', 'RNA, Viral', 'Simian virus 40'] | 2,170,946 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['L01.453.245.667'], ['G05.365.590'], ['D13.695.578.550.500'], ['D13.444.735.544'], ['D13.444.735.828'], ['B04.280.210.700.615.700', 'B04.613.204.670.615.700']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A novel group of multi-GAP-domain proteins. | The Rho GTPase-activating proteins (RhoGAPs) play an essential role in regulating various cellular processes. Rat tGAP1 is the first reported protein that has multiple GAP domains. It is exclusively expressed in male germ cells. However, tGAP1 does not possess GAP activities in vitro. No tGAP1 homology has been identif... | ['Amino Acid Sequence', 'Animals', 'Databases, Genetic', 'Dogs', 'Evolution, Molecular', 'GTPase-Activating Proteins', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence Data', 'Phylogeny', 'Protein Structure, Tertiary', 'Rats', 'Sequence Homology, Amino Acid'] | 18,363,199 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['B01.050.150.900.649.313.750.250.216.200'], ['G05.045.250', 'G16.075.250'], ['D12.644.360.325.150', 'D12.776.476.325.150'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[The effect of modification of lactate and malate dehydrogenases on their stability and activity]. | The inactivation of lactate and malate dehydrogenases (LDH and MDH) modified by progesterone in the water-dimethylformamide (DMF) medium is described by the first-order equation up to large conversion degrees. The MDH modification is accompanied by the increase of its stability by 7-14%, while LDH modification leads to... | ['Animals', 'Catalysis', 'Dimethylformamide', 'Enzyme Stability', 'In Vitro Techniques', 'Kinetics', 'L-Lactate Dehydrogenase', 'Malate Dehydrogenase', 'Mitochondria, Heart', 'Progesterone', 'Protein Conformation', 'Solutions', 'Swine', 'Temperature'] | 2,346,762 | [['B01.050'], ['G02.130'], ['D02.065.463.387', 'D02.241.081.420.500.387'], ['E05.916.360', 'G02.111.700.500'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['D08.811.682.047.820.496'], ['A11.284.430.214.190.875.564.627.603', 'A11.284.835.626.627.603'], ['D04.210.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Generalization of features in the assembly neural networks. | The purpose of the paper is an experimental study of the formation of class descriptions, taking place during learning, in assembly neural networks. The assembly neural network is artificially partitioned into several sub-networks according to the number of classes that the network has to recognize. The features extrac... | ['Algorithms', 'Artificial Intelligence', 'Neural Networks, Computer', 'Neurons'] | 15,034,946 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['G17.485', 'L01.224.050.375.605'], ['A08.675', 'A11.671']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Psychometrics of the Eschelle questionnaire to measure self efficacy in work capacity]. | INTRODUCTION: Self-efficacy with regard to work capacity is one of the determinants of return to work among workers with musculoskeletal disorders (MSDs). To our knowledge, the self-administered questionnaire named Echelle de mesure du sentiment d'efficacit? personnelle is the only work-specific scale available in Fren... | ['Adult', 'Disabled Persons', 'Factor Analysis, Statistical', 'Female', 'Humans', 'Male', 'Musculoskeletal Diseases', 'Psychometrics', 'Self Efficacy', 'Sick Leave', 'Surveys and Questionnaires', 'Work Capacity Evaluation'] | 22,338,298 | [['M01.060.116'], ['M01.150'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05'], ['F04.711.780'], ['F01.752.747.792.700'], ['N01.824.417.700.662', 'N04.452.677.800.662'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E01.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Density-dependent changes in the amount of sulfated glycosaminoglycans associated with mouse 3T3 cells. | The relative amount of sulfated glycosaminoglycans associated with the cell layer of parent and SV40-transformed Swiss mouse 3T3 cells was determined from the incorporation of labeled sulfate (35SO4) into macromolecular material. In cultures of SV40-transformed cells, the glycosaminoglycan content per cell was constant... | ['Cell Count', 'Cell Line', 'Cell Transformation, Neoplastic', 'Chondroitin', 'Chondroitin Sulfates', 'Glycosaminoglycans', 'Heparitin Sulfate'] | 134,041 | [['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['A11.251.210'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D09.698.373.200'], ['D09.698.373.200.300'], ['D09.698.373'], ['D09.698.373.425']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mass balance study of [?⁴C]eribulin in patients with advanced solid tumors. | This mass balance study investigated the metabolism and excretion of eribulin, a nontaxane microtubule dynamics inhibitor with a novel mechanism of action, in patients with advanced solid tumors. A single approximately 2 mg (approximately 80 ìCi) dose of [?⁴C]eribulin acetate was administered as a 2 to 5 min bolus inje... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Biotransformation', 'Carbon Radioisotopes', 'Feces', 'Female', 'Furans', 'Half-Life', 'Humans', 'Ketones', 'Male', 'Metabolic Clearance Rate', 'Microtubules', 'Middle Aged', 'Neoplasms', 'Tubulin Modulators'] | 22,041,109 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['A12.459'], ['D03.383.312'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.522'], ['E01.370.225.843', 'E05.200.843', 'G03.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile. | Uridine-5'-diphospho-1-alpha-d-glucose (UDP-Glc) is a common substrate used by glucosyltransferases, including certain bacterial toxins such as Toxins A and B from Clostridium difficile. Fluorescent analogs of UDP-Glc have been prepared for use in our studies of the clostridial toxins. These compounds are related to th... | ['Bacterial Toxins', 'Binding, Competitive', 'Catalytic Domain', 'Clostridioides difficile', 'Enterotoxins', 'Enzyme Activation', 'Fluorescent Dyes', 'Isomerism', 'Magnesium', 'Spectrometry, Fluorescence', 'Substrate Specificity', 'Uridine Diphosphate Glucose', 'ortho-Aminobenzoates'] | 12,135,481 | [['D23.946.123'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['B03.353.625.657.500'], ['D23.946.330'], ['G02.111.263', 'G03.328'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['G02.111.570.685', 'G02.607.445'], ['D01.268.552.437', 'D01.268.557.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Performers' responses to stressors encountered in sport organisations. | We investigated athletes' responses to organisational stressors. Ten sport performers (five males and five females) were interviewed with regard to the organisational-related demands they had encountered and their responses to these stressors. The main emotional responses that were revealed were anger, anxiety, disappo... | ['Adaptation, Psychological', 'Adult', 'Attitude', 'Behavior', 'Culture', 'Emotions', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Motivation', 'Organizations', 'Personal Satisfaction', 'Sports', 'Stress, Psychological', 'Verbal Behavior', 'Young Adult'] | 22,236,205 | [['F01.058'], ['M01.060.116'], ['F01.100'], ['F01.145'], ['I01.076.201.450', 'I01.880.853.100'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['F01.658', 'F01.752.543.500.750'], ['N03.540'], ['F01.145.677'], ['I03.450... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Phase-difference on seal whisker surface induces hairpin vortices in the wake to suppress force oscillation. | Seals are able to use their uniquely shaped whiskers to track hydrodynamic trails generated 30 s ago and detect hydrodynamic velocities as low as 245 [Formula: see text]m s-1. The high sensibility has long thought to be related to the wavy shape of the whiskers. This work revisited the hydrodynamics of a seal whisker m... | ['Animals', 'Biomechanical Phenomena', 'Biomimetics', 'Hydrodynamics', 'Models, Biological', 'Phoca', 'Vibrissae'] | 31,342,935 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['H01.158.550.100', 'J01.897.120.100'], ['G01.342'], ['E05.599.395'], ['B01.050.150.900.649.313.750.250.700.600'], ['A13.950']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Phenotyping of epidermal dendritic cells allows the differentiation between extrinsic and intrinsic forms of atopic dermatitis. | UNLABELLED: Atopic dermatitis (AD) is a clinically characteristic, chronic inflammatory skin disease of unknown origin. IgE-mediated uptake and antigen focusing of environmental allergens by dendritic cells (DCs) is assumed to be a central immunopathogenetic event. A so-called intrinsic type of AD (IAD) has been deline... | ['Adolescent', 'Adult', 'Age of Onset', 'Aged', 'Aged, 80 and over', 'CD36 Antigens', 'Cell Differentiation', 'Child', 'Child, Preschool', 'Dendritic Cells', 'Dermatitis, Atopic', 'Female', 'Flow Cytometry', 'Humans', 'Immunophenotyping', 'Infant', 'Male', 'Middle Aged', 'Phenotype', 'Receptors, IgG'] | 11,122,020 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.157.530.300.500', 'D12.776.395.550.625.136', 'D12.776.543.550.625.136', 'D12.776.543.585.300.500', 'D12.776.543.750.011', 'D12.776.543.750.705.675.136', 'D12.776.543.750.705.940.625... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Metallothionein expression correlates with metastatic and proliferative potential in squamous cell carcinoma of the oesophagus. | The goal of this study is to clarify whether the expression of metallothionein (MT) could affect the prognosis and the metastatic potential of squamous cell carcinoma (SCC) of the oesophagus. In paraffin-embedded specimens resected from 57 patients, MT mRNA and protein expressions were detected by in situ hybridization... | ['Aged', 'Base Sequence', 'Carcinoma, Squamous Cell', 'Cell Division', 'Esophageal Neoplasms', 'Female', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization', 'Male', 'Metallothionein', 'Middle Aged', 'Molecular Sequence Data', 'Proliferating Cell Nuclear Antigen', 'RNA, Messenger'] | 10,574,261 | [['M01.060.116.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.90... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Laboratory testing of whole cell pertussis vaccine: a WHO proficiency study using the Kendrick test. | Whole cell pertussis vaccine (WCV), commonly in combination with vaccines for diphtheria and tetanus, has an important role in reducing morbidity and mortality among children in most parts of the world. Testing to assure the efficacy of such vaccines is essential. We have, therefore, carried out, under the Global Train... | ['Animals', 'Humans', 'Lethal Dose 50', 'Mice', 'Pertussis Vaccine', 'World Health Organization'] | 11,672,896 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['B01.050.150.900.649.313.992.635.505.500'], ['D20.215.894.135.535'], ['N03.540.514.718.800']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Over-the-counter decorative contact lenses: Cosmetic or Medical Devices? A Case Series. | PURPOSE: To illustrate the implications of the unauthorized sale and unmonitored wearing of decorative cosmetic contact lenses resulting in ocular complications and to determine the prevalence of the use of cosmetic contact lenses obtained from unlicensed providers by adolescents.METHODS: Observational case report, str... | ['Adolescent', 'Adult', 'Blindness', 'Contact Lenses', 'Corneal Diseases', 'Cosmetics', 'Device Approval', 'Equipment Safety', 'Eye Infections, Bacterial', 'Female', 'Humans', 'Male', 'Prosthesis Fitting', 'Retrospective Studies'] | 16,163,010 | [['M01.060.057'], ['M01.060.116'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['E07.632.500.276'], ['C11.204'], ['D27.720.269', 'J01.516.213'], ['E05.337.275', 'N06.850.210.275'], ['E05.330'], ['C01.150.252.289', 'C01.375.354', 'C11.294.354'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Long-term Safety and Efficacy of Reslizumab in Patients with Eosinophilic Asthma. | BACKGROUND: In placebo-controlled trials, reslizumab, an anti-IL-5 monoclonal antibody, significantly reduced asthma exacerbations and improved lung function and asthma control in patients with eosinophilic asthma.OBJECTIVE: This open-label extension study evaluated safety and efficacy of reslizumab for up to 24 months... | ['Adolescent', 'Adult', 'Aged', 'Anti-Asthmatic Agents', 'Antibodies, Monoclonal, Humanized', 'Asthma', 'Child', 'Eosinophils', 'Female', 'Follow-Up Studies', 'Humans', 'Immunotherapy', 'Interleukin-5', 'Male', 'Middle Aged', 'Nasopharyngitis', 'Neoplasms', 'Respiratory Function Tests', 'Survival Analysis', 'Young Adul... | 29,122,156 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.796.050'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['A11.118.637.415.345', 'A11.627.340.345'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
NYVAC immunization induces polyfunctional HIV-specific T-cell responses in chronically-infected, ART-treated HIV patients. | We report the results of the Theravac-01 phase I trial, which was conducted to evaluate the safety and immunogenicity of a poxvirus-based vector, NYVAC, expressing Gag, Pol, Nef, and Env from an HIV clade B isolate. NYVAC-B vaccine was injected intra-muscularly into ten HIV-infected patients successfully treated with a... | ['Adult', 'Anti-HIV Agents', 'CD4 Lymphocyte Count', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Cell Growth Processes', 'Enzyme-Linked Immunosorbent Assay', 'Flow Cytometry', 'HIV', 'HIV Infections', 'Humans', 'Interferon-gamma', 'Male', 'Middle Aged', 'RNA, Viral', 'Switzerland', 'Viral Vaccines'] | 22,930,439 | [['M01.060.116'], ['D27.505.954.122.388.077.088'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['A11.118.637.555.567.569.200', 'A15.145.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
RT-qPCR for the diagnosis of dermatophilosis in horses. | BACKGROUND: Dermatophilus congolensis causes a crusting dermatitis that affects horses. Diagnosis requires the identification of the organism with cytological evaluation of crust samples. This method can lack sensitivity in chronic cases.HYPOTHESIS/OBJECTIVES: To develop a probe-based real time quantitative polymerase ... | ['Actinobacteria', 'Animals', 'Gram-Positive Bacterial Infections', 'Horse Diseases', 'Horses', 'Reverse Transcriptase Polymerase Chain Reaction', 'Skin Diseases, Bacterial'] | 27,485,381 | [['B03.510.024', 'B03.510.460.400.400.049'], ['B01.050'], ['C01.150.252.410'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['E05.393.620.500.725'], ['C01.150.252.819', 'C01.800.720', 'C17.800.838.765']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group. | Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are prognostic in breast cancer with potential relevance for response to immune-checkpoint inhibitor therapy. Although many groups are currently evaluating TIL, there is no standardized system for diagnostic applications. This study repor... | ['Breast Neoplasms', 'Female', 'Humans', 'Image Interpretation, Computer-Assisted', 'Lymphocytes, Tumor-Infiltrating', 'Pathology, Clinical'] | 27,363,491 | [['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['A11.118.637.555.567.650', 'A15.145.229.637.555.567.650', 'A15.382.490.555.567.650'], ['H02.403.650.500']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Score to predict hypertension in working male population]. | BACKGROUND AND OBJECTIVE: Hypertension is the most prevalent risk factor in the community. The aim of this study was to describe the risk factors for the progression of blood pressure (BP) from correct values.SUBJECTS AND METHODS: Prospective and observational study with 7 years follow-up. BP>140/90 mmHg was considered... | ['Adult', 'Blood Pressure', 'Body Mass Index', 'Comorbidity', 'Disease Progression', 'Dyslipidemias', 'Employment', 'Follow-Up Studies', 'Humans', 'Hyperglycemia', 'Hypertension', 'Hypertriglyceridemia', 'Hyperuricemia', 'Lipoproteins, LDL', 'Male', 'Middle Aged', 'Models, Biological', 'Multivariate Analysis', 'Obesity... | 23,199,830 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['N05.715.350.225', 'N06.850.490.687'], ['C23.550.291.656'], ['C18.452.584.500'], ['N01.824.245'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Alteration of vertical dimension and its effect on head and neck posture. | Previous research has shown a relationship between head posture and rest position of the mandible. Should this relationship really be an interrelationship? Does a change in mandibular posture alone also alter head and neck posture? The purpose of this article is to demonstrate how a change in mandibular posture, specif... | ['Adaptation, Physiological', 'Head', 'Humans', 'Neck', 'Neck Muscles', 'Physical Therapy Modalities', 'Posture', 'Splints', 'Vertical Dimension'] | 1,802,428 | [['G07.025', 'G16.012.500'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.598'], ['A02.633.567.650'], ['E02.779', 'E02.831.535'], ['G11.427.695'], ['E07.858.442.660.430.750', 'E07.858.690.725.430.750'], ['E06.276.459.733']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mapping resistance to powdery mildew in barley reveals a large-effect nonhost resistance QTL. | KEY MESSAGE: Resistance factors against non-adapted powdery mildews were mapped in barley. Some QTLs seem effective only to non-adapted mildews, while others also play a role in defense against the adapted form. The durability and effectiveness of nonhost resistance suggests promising practical applications for crop br... | ['Ascomycota', 'Chromosome Mapping', 'Disease Resistance', 'Hordeum', 'Phenotype', 'Plant Diseases', 'Quantitative Trait Loci'] | 29,372,282 | [['B01.300.107'], ['E05.393.183'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['B01.650.940.800.575.912.250.822.481'], ['G05.695'], ['G15.610'], ['G05.360.340.024.380.937']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Removal of well-fixed flanged humeral prostheses may require humeral expansion. | BACKGROUND: A flanged humeral stem design can be advantageous in achieving an interlock between the prosthetic and bone interface leading to a long-term stable loading pattern. The purpose of this study is to report a short case series involving revision of a flanged humeral prosthesis. Our hypothesis was that a greate... | ['Aged', 'Arthroplasty, Replacement', 'Chi-Square Distribution', 'Cohort Studies', 'Device Removal', 'Female', 'Follow-Up Studies', 'Humans', 'Humerus', 'Joint Prosthesis', 'Male', 'Middle Aged', 'Osteotomy', 'Pain Measurement', 'Pain, Postoperative', 'Probability', 'Prosthesis Design', 'Prosthesis Failure', 'Range of ... | 19,318,282 | [['M01.060.116.100'], ['E04.555.110.110', 'E04.650.110', 'E04.680.101.110'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E04.199'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. | The plasma from many vertebrates contains a component that specifically binds and inhibits carbonic anhydrase II with nanomolar affinity. Amino-terminal sequencing of pICA, the previously identified 79-kDa carbonic anhydrase inhibitor isolated from porcine plasma [Roush, E. D., & Fierke, C. A. (1992) Biochemistry 31, 1... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Blood Proteins', 'Blotting, Western', 'Carbonic Anhydrase Inhibitors', 'Carbonic Anhydrases', 'Carrier Proteins', 'Cloning, Molecular', 'Electrophoresis, Polyacrylamide Gel', 'Gene Expression', 'Immunoblotting', 'Iron-Binding Proteins', 'Metals', 'Molecular Sequence ... | 9,100,029 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.124'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D27.505.519.389.200'], ['D08.811.520.241.300.150'], ['D12.776.157'], ['E05.393.220'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Type 2 diabetes among persons with schizophrenia and other psychotic disorders in a general population survey. | Schizophrenia and other psychotic disorders are associated with increased risk of developing type 2 diabetes. However, previous studies are mainly based on clinical samples where the comorbidity may be stronger. We investigated in a general population survey the prevalence of type 2 diabetes in persons with psychotic d... | ['Age Distribution', 'Antipsychotic Agents', 'Blood Glucose', 'Chi-Square Distribution', 'Comorbidity', 'Diabetes Mellitus, Type 2', 'Female', 'Finland', 'Health Surveys', 'Humans', 'Insulin', 'Male', 'Middle Aged', 'Mood Disorders', 'Prevalence', 'Psychotic Disorders', 'Schizophrenia'] | 17,990,051 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D09.947.875.359.448.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N05.715.350.225', 'N06.850.490.687'], ['C18.452.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Introduction to epistemology in nursing sciences]. | The development of nursing research is one of the stages in the process for the professionalization of nurses. An epistemological reflection which took place gradually became necessary. Today, three traditions derived from the positivist, interpretative and critical approaches orientate reflections on nursing sciences,... | ['Humans', 'Knowledge', 'Models, Nursing', "Nurse's Role", 'Nursing Research', 'Philosophy, Nursing', 'Postmodernism', 'Professional Autonomy'] | 21,449,197 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.468'], ['E05.599.645'], ['F01.829.316.616.625.450', 'N05.300.100.337'], ['H01.770.644.145.390', 'H02.478.395', 'N04.590.233.508.613'], ['K01.752.712'], ['K01.752.720'], ['N04.452.758.752']] | ['Organisms [B]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A dose-up of ursodeoxycholic acid decreases transaminases in hepatitis C patients. | AIM: To examine whether a dose-up to 900 mg of ursodeoxycholic acid (UDCA) decreases transaminases in hepatitis C patients.METHODS: From January to December 2007, patients with chronic hepatitis C or compensated liver cirrhosis with hepatitis C virus (HCV) (43-80 years old) showing positive serum HCV-RNA who had alread... | ['Adult', 'Aged', 'Aged, 80 and over', 'Alanine Transaminase', 'Animals', 'Aspartate Aminotransferases', 'Bilirubin', 'Blood Platelets', 'Dose-Response Relationship, Drug', 'Female', 'Hepacivirus', 'Hepatitis C', 'Humans', 'Male', 'Middle Aged', 'Serum Albumin', 'Ursodeoxycholic Acid', 'gamma-Glutamyltransferase'] | 19,522,030 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D08.811.913.477.700.100'], ['B01.050'], ['D08.811.913.477.700.225'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['A11.118.188', 'A15.145.229.188'], ['G07.690.773.875', 'G07.690.936.500'], ['B04.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Insecticidal activity of selected actinomycete strains against the Egyptian cotton leaf worm Spodoptera littoralis (Lepidoptera: Noctuidae). | Actinomycete strains isolated from soil samples of Saudi Arabia and Egypt were used in the present study to investigate the biological activity of their secondary metabolites on the cotton leaf worm Spodoptera littoralis. Secondary metabolites of 41 strains were given to the newly molted last instar larvae through the ... | ['Actinomycetales', 'Animals', 'Antibiosis', 'Colony Count, Microbial', 'Gossypium', 'Life Cycle Stages', 'Pest Control, Biological', 'Soil Microbiology', 'Spodoptera'] | 12,425,071 | [['B03.510.024.049'], ['B01.050'], ['G06.550.050', 'G16.062'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['B05.500', 'G07.345.500.550.500'], ['N06.850.780.200.650.650'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['B01.050.500.131.617.720.500.500.937.650.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Behavior patterns associated with institutional deprivation: a study of children adopted from Romania. | This study examined the prevalence and persistence of behaviors associated with institutional rearing in a sample of 144 children from Romania adopted by UK families. Patterns of rocking, self-injury, unusual sensory interests, and eating problems were assessed in children aged between a few weeks and 43 months who wer... | ['Adoption', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Institutionalization', 'Male', 'Psychosocial Deprivation', 'Romania', 'Self-Injurious Behavior'] | 12,394,517 | [['I01.880.853.150.140'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E02.760.415', 'N02.421.585.415'], ['F01.829.628', 'I01.880.853.100.806'], ['Z01.542.248.764'], ['F01.145.126.980']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The effect of sodium bicarbonate on cytokine secretion in CKD patients with metabolic acidosis. | The incidence of acidosis increases with the progression of chronic kidney disease (CKD). Correction of acidosis by sodium bicarbonate may slow CKD deterioration. Inflammation, which is common in CKD, may be related to acidosis. Whether the slower rate of GFR decline following the correction of acidosis is related to c... | ['Acidosis', 'Cytokines', 'Demography', 'Female', 'Humans', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Renal Insufficiency, Chronic', 'Sodium Bicarbonate'] | 25,960,222 | [['C18.452.076.176'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555', 'A15.145.229.637.555', 'A15.382.490.555'], ['M01.060.116.630'], ['C12.777.419.780.750', 'C13.351.968.419.780.750'], ['D01.200.275.1... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Self-stimulation in an adult misdiagnosed with focal epilepsy. | Self-stimulation is a normal part of development and a common behaviour in children before puberty, but very rare in adults. The stereotyped semiology can sometimes raise the suspicion of epilepsy. We present a 30-year-old patient who came to our epilepsy monitoring unit for differential diagnosis of nocturnal episodes... | ['Adult', 'Diagnosis, Differential', 'Diagnostic Errors', 'Electroencephalography', 'Epilepsies, Partial', 'Female', 'Humans', 'Monitoring, Physiologic', 'Seizures', 'Status Epilepticus'] | 31,638,581 | [['M01.060.116'], ['E01.171'], ['E01.354', 'N02.421.450.280'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520'], ['C10.597.742', 'C23.888.592.742'], ['C10.597.742.785', 'C23.888.592.742.785']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The impact of emerging safety and effectiveness evidence on the use of physician-administered drugs: the case of bevacizumab for breast cancer. | BACKGROUND: Spending on physician-administered drugs is high and uses not approved by the US Food and Drug Administration (FDA) are frequent. Although these drugs may be targets of future policy efforts to rationalize use, little is known regarding how physicians respond to emerging safety and effectiveness evidence.ST... | ['Aged', 'Angiogenesis Inhibitors', 'Antibodies, Monoclonal, Humanized', 'Bevacizumab', 'Breast Neoplasms', 'Evidence-Based Medicine', 'Female', 'Humans', 'Medical Order Entry Systems', 'Middle Aged', 'Patient Safety', "Practice Patterns, Physicians'", 'Regression Analysis', 'Treatment Outcome', 'United States'] | 23,604,014 | [['M01.060.116.100'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D12.776.124.486.485.114.224.060.375', 'D12.776.124.790.651.114.224.060.438', 'D12.776.377.715.548.114.224.200.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
B-cell precursors specific to sheep erythrocytes. Estimation of frequency in a specific helper assay. | A sensitive, specific, and reproducible in vitro helper assay is described which is suited to limiting dilution analysis of murine B cells. 1 in about 3,000 syngeneic splenic B cells can be induced to form plaque-forming cells (PFC) to sheep erythrocytes in this system. The induction of PFC is absolutely dependent on a... | ['Animals', 'Antibody Formation', 'B-Lymphocytes', 'Cell Differentiation', 'Cells, Cultured', 'Dose-Response Relationship, Immunologic', 'Erythrocytes', 'Female', 'Lymphocyte Cooperation', 'Male', 'Mice', 'Mice, Inbred Strains', 'Sheep', 'T-Lymphocytes'] | 309,925 | [['B01.050'], ['G12.450.050.370.250'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.152'], ['A11.251'], ['G12.300'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G04.502', 'G12.575'], ['B01.050.150.900.649.313.992.635.505.500'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Azithromycin versus placebo in acute infectious rhinitis with clinical symptoms but without radiological signs of maxillary sinusitis. | In this double-blind, parallel-group, multicenter study, 169 patients with symptoms of maxillary sinusitis but without radiographically confirmed empyema (pus) were randomly assigned to receive either 500 mg azithromycin once daily for 3 days (87 patients) or placebo daily for 3 days (82 patients). Nasal secretion, max... | ['Adolescent', 'Adult', 'Aged', 'Anti-Bacterial Agents', 'Azithromycin', 'Double-Blind Method', 'Female', 'Humans', 'Male', 'Maxillary Sinusitis', 'Middle Aged', 'Rhinitis', 'Treatment Outcome'] | 9,721,958 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['D02.540.576.500.992.050'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.748.749.578', 'C08.460.692.752.578', 'C08.730.749.578', 'C09.603.692.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of the BD GeneOhm assay using the rotor-gene 6000 platform for rapid detection of methicillin-resistant Staphylococcus aureus from pooled screening swabs. | As health services move toward universal methicillin-resistant Staphylococcus aureus (MRSA) screening for hospital admissions, the most cost-effective approach is yet to be defined. In this study, one of the largest to date, we evaluated the performance of the BD GeneOhm MRSA assay on the Rotor-Gene 6000 thermal cycler... | ['Bacteriological Techniques', 'Carrier State', 'Humans', 'Mass Screening', 'Methicillin-Resistant Staphylococcus aureus', 'Polymerase Chain Reaction', 'Sensitivity and Specificity', 'Specimen Handling', 'Staphylococcal Infections'] | 20,962,146 | [['E01.370.225.875.150', 'E05.200.875.150'], ['N06.850.520.169'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['B03.300.390.400.800.750.100.500', 'B03.353.500.750.750.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Computer analysis of band variability in DNA fingerprints]. | Through the example of the distribution of PCR products DNA matrices of mouse tail tissue, a method of comparative analysis of DNA fingerprints is described. The PCR products were obtained using a 20-mer random primer flanking the Atp1b2 locus on mouse chromosome 11. A software program was designed that permits the sim... | ['Animals', 'DNA', 'DNA Fingerprinting', 'Electronic Data Processing', 'Humans', 'Mice', 'Software'] | 10,822,822 | [['B01.050'], ['D13.444.308'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['L01.224.085'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.224.900']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Use of a potentiometric vital dye to determine the effect of the herbicide bromoxynil octanoate on mitochondrial bioenenergetics in Chlamydomonas reinhardtii. | BACKGROUND: The aims of the present study were to validate a vital mitochondrial potentiometric staining method in Chlamydomonas reinhardtii and to utilise this method to examine the effect of the herbicide bromoxynil octanoate on mitochondrial potential in this species. A range of stains was investigated, including Rh... | ['Chlamydomonas reinhardtii', 'Energy Metabolism', 'Fluorescent Dyes', 'Herbicides', 'Membrane Potential, Mitochondrial', 'Mitochondria', 'Nitriles', 'Potentiometry'] | 22,500,292 | [['B01.650.940.150.385.650'], ['G03.295'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D27.720.031.700.366', 'D27.888.723.366'], ['G03.295.770.500', 'G04.580.550', 'G07.265.675.550'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D02.626'], ['E05.196.922.750', 'E05.301.710']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension. | Heightened pulmonary artery smooth muscle cell (PA-SMC) proliferation and migration and dynamic remodeling of the extracellular matrix are hallmark pathogenic features of pulmonary arterial hypertension (PAH). Pirfenidone (PFD) is an orally bioavailable pyridone derivative with antifibrotic, antiinflammatory, and antio... | ['Animals', 'Cell Proliferation', 'Cells, Cultured', 'Disease Models, Animal', 'Extracellular Matrix', 'Humans', 'Hypertension, Pulmonary', 'Hypoxia', 'Lung', 'Male', 'Muscle, Smooth, Vascular', 'Pulmonary Artery', 'Pyridones', 'Rats', 'Rats, Wistar', 'Vascular Remodeling'] | 30,481,487 | [['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.907.489.556'], ['C23.888.852.079'], ['A04.411'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['A07.0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychosocial correlates of depression symptoms during the third trimester of pregnancy. | OBJECTIVE: To explore the psychosocial correlates of depression symptoms during the third trimester of pregnancy.DESIGN: Cross-sectional design guided by Selye's theory of stress.SETTING: Prenatal care provider offices or mutually agreeable locations in the Pacific Northwest.PARTICIPANTS: One hundred thirty-nine women ... | ['Adult', 'Causality', 'Comorbidity', 'Cross-Sectional Studies', 'Depression', 'Female', 'Health Behavior', 'Humans', 'Internal-External Control', 'Nursing Evaluation Research', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Trimester, Third', 'Prenatal Care', 'Self Concept', 'Social Adjustment', 'Social Support', ... | 17,489,929 | [['M01.060.116'], ['N05.715.350.200', 'N06.850.490.625'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.379'], ['H01.770.644.145.390.432', 'H02.478.39... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Discordance of mercury sphygmomanometer and ambulatory blood pressure measurements for the detection of untreated hypertension in a population study. | To evaluate the extent to which ambulatory blood pressure (ABP) measurements could redefine the prevalence of untreated hypertension in the general population, we studied a randomly selected subgroup of the National Heart Foundation of Australia's Risk Factor Prevalence Study 1989. Subjects taking blood pressure (BP) l... | ['Adult', 'Ambulatory Care', 'Blood Pressure Determination', 'Blood Pressure Monitors', 'Female', 'Humans', 'Hypertension', 'Male', 'Mercury', 'Middle Aged'] | 8,263,887 | [['M01.060.116'], ['E02.760.106', 'N02.421.585.106'], ['E01.370.370.140', 'E01.370.600.100'], ['E07.230.740.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Resolution of sexual dysfunction during double-blind treatment of major depression with reboxetine or paroxetine. | The selective noradrenaline re-uptake inhibitor reboxetine may have advantages over the selective serotonin re-uptake inhibitors fluoxetine and citalopram, in effects on sexual function and satisfaction. The effects of reboxetine and paroxetine on sexual function were compared by examining data from the UK centres in a... | ['Adult', 'Antidepressive Agents, Second-Generation', 'Depressive Disorder, Major', 'Double-Blind Method', 'Female', 'Humans', 'Male', 'Middle Aged', 'Morpholines', 'Paroxetine', 'Psychiatric Status Rating Scales', 'Reboxetine', 'Sexual Behavior', 'Sexual Dysfunctions, Psychological'] | 16,204,325 | [['M01.060.116'], ['D27.505.954.427.700.122.050'], ['F03.600.300.375'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.383.533.640'], ['D03.383.621.600'], ['F04.711.513.653'], ['D03.383.533.640.682'], ['F0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression. | The AAA-ATPase TRIP13 drives multiple myeloma progression. Here, we present the crystal structure of wild-type human TRIP13 at a resolution of 2.6 ?. A small-molecule inhibitor targeting TRIP13 was identified on the basis of the crystal structure. The inhibitor, designated DCZ0415, was confirmed to bind TRIP13 using pu... | ['ATPases Associated with Diverse Cellular Activities', 'Animals', 'Antineoplastic Combined Chemotherapy Protocols', 'Apoptosis', 'Cell Cycle Proteins', 'Cell Proliferation', 'Crystallography, X-Ray', 'Disease Progression', 'Enzyme Inhibitors', 'Humans', 'Melphalan', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Multip... | 31,732,653 | [['D08.811.277.040.013.500', 'D08.811.277.040.025.024', 'D12.776.157.025.750'], ['B01.050'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['G04.146.954.035'], ['D12.776.167'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.196.309.742.225'], ['C23.550.291.656'], ['D27.505.519.389'], ['B01.050.150.900.649.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Platelet activity and serum homocysteine levels in patients with end-stage renal failure with regard to dialysis modality. | BACKGROUND: Recent evidence suggests that the activation of platelets and their interaction with circulating cells are important independent risk factors for atherosclerosis. In non-uremic patients with symptomatic peripheral vascular disease, a relationship between serum homocysteine (Hcy) levels and platelet activity... | ['Aged', 'Analysis of Variance', 'Female', 'Homocysteine', 'Humans', 'Hypertrophy, Left Ventricular', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'P-Selectin', 'Peritoneal Dialysis, Continuous Ambulatory', 'Platelet Activation', 'Renal Dialysis', 'Statistics, Nonparametric'] | 16,771,245 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D02.886.030.498', 'D12.125.166.498'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.195.400', 'C23.300.775.250.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['M01.060.116.630'], ['D12.776.395.550... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multiple sites required for expression in 5'-flanking region of the hMLH1 gene. | Expression of the hMLH1 gene, one of the DNA mismatch repair genes, is frequently repressed in various cancers such as colorectal, ovarian, gastric, and endometrial origins with a microsatellite instable phenotype. In this study, we investigated details of the relationship between the transcriptional activity and the p... | ["5' Flanking Region", 'Adaptor Proteins, Signal Transducing', 'Base Sequence', 'Binding Sites', 'CCAAT-Binding Factor', 'Carrier Proteins', 'DNA', 'Electrophoretic Mobility Shift Assay', 'Gene Expression', 'Humans', 'Luciferases', 'Molecular Sequence Data', 'MutL Protein Homolog 1', 'Mutation', 'Neoplasm Proteins', 'N... | 12,657,467 | [['G05.360.340.024.220.282', 'G05.360.340.024.340.137.295'], ['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D12.776.260.108.124.249', 'D12.776.660.167.249', 'D12.776.930.127.124.249'], ['D12.776.157'], ['D13.444.308'], ['E05.1... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Successful closure of a rectovaginal fistula by using an endoscopically placed Resolution clip. | BACKGROUND: Rectovaginal fistula (RVF) is an abnormal epithelium-lined communication between the wall of the rectum and the posterior vaginal wall. The incidence of RVFs is low and accounts for about 5% of all anorectal fistulas. Women who suffer from an RVF complain of uncontrollable passage of gas or feces from the v... | ['Aged', 'Female', 'Follow-Up Studies', 'Humans', 'Minimally Invasive Surgical Procedures', 'Rectovaginal Fistula', 'Risk Assessment', 'Severity of Illness Index', 'Sigmoidoscopy', 'Surgical Instruments', 'Treatment Outcome'] | 18,402,957 | [['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.502'], ['C06.267.550.600.650', 'C06.405.469.471.600.650', 'C06.405.469.860.752.650', 'C13.351.500.894.767.249', 'C23.300.575.185.550.600.650', 'C23.300.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nonosseous athletic injuries of the elbow, forearm, and hand. | This article deals with soft-tissue injuries of the upper extremity incurred by competitive athletes. The authors describe the pathophysiology, conservative and operative management of musculotendinous elbow injuries, entrapment neuropathy, tendinous disorders, vascular injuries, and dermatologic conditions in athletes... | ['Athletic Injuries', 'Blister', 'Blood Vessels', 'Callosities', 'Carpal Tunnel Syndrome', 'Elbow', 'Forearm Injuries', 'Hand Injuries', 'Humans', 'Muscles', 'Nerve Compression Syndromes', 'Protective Devices', 'Radial Nerve', 'Tendon Injuries', 'Ulnar Nerve'] | 3,768,972 | [['C26.115'], ['C17.800.865.187', 'C23.300.122'], ['A07.015'], ['C17.800.428.200'], ['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['A01.378.800.420'], ['C26.088.268'], ['C26.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633', 'A10.690'], ['C10.668.829.550'], ['E07.700', 'J01.637... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Immunoassay by capillary electrophoresis with quantum dots. | The application of quantum dots in capillary electrophoresis immunoassay was studied for the first time. Quantum dots were conjugated with antibody and subsequently tested by electrophoretic separation of free antibody and antibody-antigen complex. Antibody was fluorescently labeled by quantum dots via conjugation proc... | ['Electrophoresis, Capillary', 'Humans', 'Immunoassay', 'Immunoglobulin M', 'Quantum Dots'] | 17,208,246 | [['E05.196.401.190', 'E05.301.300.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566', 'E05.601.470'], ['D12.776.124.486.485.114.619.574', 'D12.776.124.790.651.114.619.574', 'D12.776.377.715.548.114.619.574'], ['E07.705', 'J01.637.512.600.650']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Ingestive behavior of grazing steers fed increasing levels of concentrate supplementation with different crude protein contents. | This study aimed to evaluate the ingestive behavior of steers on Brachiaria brizantha pasture fed diets with increasing levels of concentrate supplementation. Thirty-two crossbred steers in the finishing phase with average weight of 420 ± 8 kg were distributed in a completely randomized design with four treatments and ... | ['Animal Feed', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Cattle', 'Diet', 'Dietary Supplements', 'Feeding Behavior', 'Proteins'] | 25,471,365 | [['G07.203.300.300.100', 'J02.500.300.100'], ['G07.203.650.161'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.650.240'], ['G07.203.300.456', 'J02.500.456'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['D12.776']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Proline-containing cyclopeptides from the marine sponge Phakellia fusca. | Four new cyclopeptides, phakellistatins 15-18 (2-5), together with five known cyclopeptides, phakellistatin 13 (1), hymenistatin 1, and hymenamides G, H, and J, were isolated from the South China Sea sponge Phakellia fusca. Their structures were elucidated by HR-ESIMS, NMR, and MALDI-TOF/TOF sequence analysis. The abso... | ['Animals', 'Marine Biology', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Peptides, Cyclic', 'Porifera', 'Proline', 'Stereoisomerism'] | 20,345,147 | [['B01.050'], ['H01.158.273.248.750.500', 'H01.277.249.750.500', 'H01.277.750.500'], ['G02.111.570', 'G02.466'], ['E05.196.867.519.550'], ['D04.345.566', 'D12.644.641'], ['B01.050.500.802'], ['D12.125.072.401.623'], ['G02.607.445.682']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute multisystem toxicity associated with the use of nonsteroidal anti-inflammatory drugs. | Nonsteroidal anti-inflammatory drugs (NSAIDs) have been implicated as a cause of acute liver failure, acute renal failure, and acute autoimmune hemolytic anemia. Since NSAIDs are capable of causing serious injury to multiple organ systems, it is surprising that no one has observed multisystem involvement in any of the ... | ['Acute Kidney Injury', 'Anemia, Hemolytic, Autoimmune', 'Anti-Inflammatory Agents', 'Chemical and Drug Induced Liver Injury', 'Humans', 'Liver Diseases', 'Male', 'Middle Aged'] | 6,703,823 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['C15.378.071.141.125', 'C20.111.175'], ['D27.505.954.158'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552'], ['M01.060.116.630']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A single editing event is a prerequisite for efficient processing of potato mitochondrial phenylalanine tRNA. | In bean, potato, and Oenothera plants, the C encoded at position 4 (C4) in the mitochondrial tRNA Phe GAA gene is converted into a U in the mature tRNA. This nucleotide change corrects a mismatched C4-A69 base pair which appears when the gene sequence is folded into the cloverleaf structure. C-to-U conversions constitu... | ['Base Composition', 'Base Sequence', 'DNA Primers', 'Kinetics', 'Mitochondria', 'Models, Structural', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'RNA', 'RNA Editing', 'RNA, Mitochondrial', 'RNA, Plant', 'RNA, Transfer, Phe', 'Restriction Mapping', 'Solanum tuberosum'] | 8,668,166 | [['G02.111.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G01.374.661', 'G02.111.490'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['L01.453.245.667'], ['G02.111.570.820.486', 'G05.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Screening for neurocognitive impairment in HIV-positive adults aged 50 years and older: Montreal Cognitive Assessment relates to self-reported and clinician-rated everyday functioning. | As the HIV+ population ages, the risk for and need to screen for HIV-associated neurocognitive disorders (HAND) increases. The aim of this study is to determine the utility and ecological validity of the Montreal Cognitive Assessment (MoCA) among older HIV+ adults. A total of 100 HIV+ older adults aged 50 years or over... | ['AIDS Dementia Complex', 'Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Cognitive Dysfunction', 'Executive Function', 'Female', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Psychometrics', 'Self Report', 'Sensitivity and Specificity'] | 28,122,474 | [['C01.221.250.875.049', 'C01.221.812.640.400.070', 'C01.778.640.400.070', 'C01.925.782.815.616.400.049', 'C01.925.813.400.070', 'C10.228.140.380.070', 'C20.673.480.070', 'F03.615.400.050'], ['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F03.615... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The regeneration and division of mouse L-cell karyoplasts. | A technique for efficient cytochalasin-induced enucleation was used to prepare "karyoplasts"--nuclei surrounded by a thin shell of cytoplasm and an outer cell membrane. Methods for estimating the quantity of cytoplasm remaining in karyoplasts indicated that they contained less than 10% of the amount found in whole cell... | ['Cell Adhesion', 'Cell Division', 'Cell Fractionation', 'Cell Nucleus', 'Cell Separation', 'L Cells', 'RNA'] | 949,739 | [['G04.022'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.242.251'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251.210.505', 'A11.329.228.505'], ['D13.444.735']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cardiovascular disease risk factors and depression in Korean women: results from the fourth Korean National Health and Nutrition Examination Survey. | Depression is the fourth leading factor of disease burden for the global female population, but while increasing evidence has supported a contributing role of depression in cardiovascular disease, little is known about this association within the female population of Korea. We examined the association in a study of 565... | ['Adult', 'Aged', 'Anthropometry', 'Body Mass Index', 'Cardiovascular Diseases', 'Confidence Intervals', 'Depression', 'Economics', 'Female', 'Humans', 'Life Style', 'Logistic Models', 'Middle Aged', 'Nutrition Surveys', 'Odds Ratio', 'Republic of Korea', 'Risk Factors', 'Smoking'] | 21,683,455 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C14'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['F01.145.126.350'], ['I01.261', 'N03.219'], ['B01.050.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Respiratory syncytial virus (RSV) fusion protein subunit F2, not attachment protein G, determines the specificity of RSV infection. | Human respiratory syncytial virus (HRSV) and bovine RSV (BRSV) infect human beings and cattle in a species-specific manner. We have here analyzed the contribution of RSV envelope proteins to species-specific entry into cells. In contrast to permanent cell lines, primary cells of human or bovine origin, including differ... | ['Animals', 'Cattle', 'Cell Line', 'Cells, Cultured', 'Gene Deletion', 'Gene Expression Regulation, Viral', 'HN Protein', 'Humans', 'Leukocytes, Mononuclear', 'Macrophages', 'Respiratory Syncytial Virus, Bovine', 'Respiratory Syncytial Virus, Human', 'Species Specificity', 'Viral Envelope Proteins', 'Viral Fusion Prote... | 12,663,767 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251.210'], ['A11.251'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.308.385'], ['D12.776.964.970.880.350', 'D23.050.327.461.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555', 'A15.145.229.637.555', 'A15.382.490.555'], ['A11.329.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relapse observed in the treatment of phonological disorder. | BACKGROUND: relapse in phonological performance.AIM: to verify relapse in the phonological performance related to sound production in the treatment of phonological disorder.METHOD: three subjects with phonological disorders, aged 6:0, 7:0, 7:0 years, were treated for phoneme /r/ using the ABAB-Withdrawal and Multiple P... | ['Child', 'Female', 'Humans', 'Male', 'Phonetics', 'Recurrence', 'Speech Disorders', 'Speech Therapy', 'Time Factors'] | 21,103,732 | [['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.598.518'], ['C23.550.291.937'], ['C10.597.606.150.500.800', 'C23.888.592.604.150.500.800'], ['E02.760.169.063.500.727.552', 'E02.831.727.552'], ['G01.910.857']] | ['Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
HIV seroprevalence rate and incidence of adverse skin reactions in adults with pulmonary tuberculosis receiving thiacetazone free anti-tuberculosis treatment in Yaounde, Cameroon. | To determine the HIV seroprevalence in adult patients with pulmonary tuberculosis in Yaounde and to compare the incidence of adverse skin reactions in patients with and without HIV infection receiving thiacetazone-free antituberculosis treatment, we studied 235 consecutive patients aged 15 years or more admitted into t... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antitubercular Agents', 'Cameroon', 'Drug Eruptions', 'Drug Monitoring', 'Drug Therapy, Combination', 'Female', 'HIV Seroprevalence', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Sex Distribution', 'Thioacetazone', 'Tuberculosis, Pulmonary', 'Urban Health'] | 9,487,410 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085.255'], ['Z01.058.290.100.110'], ['C17.800.174.600', 'C20.543.206.380', 'C25.100.468.380'], ['E01.370.520.200'], ['E02.319.310'], ['E05.318.372.500.950.375', 'N05.715.360.330.500.950.375', 'N06.850.520.450.500.950.375'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Indicators for quality of care: who profits: patients or managers?]. | In the Netherlands and abroad detailed indicators are developed to measure quality of care for a variety of treatments and care systems. These days the development of quality indicators is a profession and business in itself. The significance of these indicators is often not related to the primary care process, but bas... | ['Geriatrics', 'Humans', 'Netherlands', 'Patient Care', 'Patient Care Management', 'Quality Indicators, Health Care', 'Quality of Health Care'] | 21,574,501 | [['H02.403.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.651'], ['E02.760', 'N02.421.585'], ['N04.590'], ['N04.761.789', 'N05.715.760'], ['N04.761', 'N05.715']] | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
MULTiPly: a novel multi-layer predictor for discovering general and specific types of promoters. | MOTIVATION: Promoters are short DNA consensus sequences that are localized proximal to the transcription start sites of genes, allowing transcription initiation of particular genes. However, the precise prediction of promoters remains a challenging task because individual promoters often differ from the consensus at on... | ['Bayes Theorem', 'Genomics', 'Promoter Regions, Genetic', 'Software', 'Transcription Initiation Site'] | 30,649,179 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['L01.224.900'], ['G05.360.340.024.340.137.750.840']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
A widespread alternate form of cap-dependent mRNA translation initiation. | Translation initiation of most mammalian mRNAs is mediated by a 5' cap structure that binds eukaryotic initiation factor 4E (eIF4E). However, inactivation of eIF4E does not impair translation of many capped mRNAs, suggesting an unknown alternate mechanism may exist for cap-dependent but eIF4E-independent translation. W... | ['Animals', 'Cell Line', 'Eukaryotic Initiation Factor-3', 'Eukaryotic Initiation Factor-4E', 'Eukaryotic Initiation Factor-4G', 'Gene Silencing', 'HEK293 Cells', 'Humans', 'Peptide Chain Initiation, Translational', 'Protein Binding', 'Protein Processing, Post-Translational', 'RNA Caps', 'RNA, Messenger', 'Ribosomes', ... | 30,076,308 | [['B01.050'], ['A11.251.210'], ['D12.776.835.725.868.437'], ['D12.776.157.725.750.374', 'D12.776.835.725.868.500.750'], ['D12.776.835.725.868.500.875'], ['G05.308.203.374'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.660.871.650', 'G03.734.871.650'], ['G02.111.679... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fats and atheroma: a retrial. | The controversy over medical endorsement of dietary measures to reduce cholesterol intake has been reconsidered. The results of several published reports that apparently do not confirm the association between diet, cholesterol concentrations, and ischaemic heart disease (IHD) were found to be largely inapplicable to th... | ['Arteriosclerosis', 'Cholesterol', 'Cholesterol, Dietary', 'Coronary Disease', 'Diet', 'Diet, Atherogenic', 'Dietary Fats', 'Fats, Unsaturated', 'Humans', 'Nutritional Physiological Phenomena'] | 435,754 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The objective evaluation of the severity of psoriatic scales with desquamation collecting tapes and image analysis. | BACKGROUND: Assessment of psoriatic scales is important to determine the severity of psoriasis. However, there are very limited numbers of objective, quantitative and observer-independent tools for measuring the severity of psoriasis.OBJECTIVE: To determine whether the bioengineering parameters of the psoriatic scale c... | ['Adolescent', 'Adult', 'Aged', 'Bioengineering', 'Child', 'Colorimetry', 'Dermoscopy', 'Elasticity Imaging Techniques', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Middle Aged', 'Photography', 'Psoriasis', 'Reference Standards', 'Severity of Illness Index', 'Surgical Tape', 'Young Adult'] | 21,507,073 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['J01.293.069'], ['M01.060.406'], ['E05.196.922.250'], ['E01.370.350.515.277.250', 'E05.595.185.250'], ['E01.370.350.850.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['M01.060.116.630'], ['E01.370.350.600', 'E05.712'], ['C17.800.859.675... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Effect of herpesvirus infection on pancreatic duct cell secretion. | AIM: To examine the effect of acute infection caused by herpesvirus (pseudorabies virus, PRV) on pancreatic ductal secretion.METHODS: The virulent Ba-DupGreen (BDG) and non-virulent Ka-RREp0lacgfp (KEG) genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent p... | ['Animals', 'Bicarbonates', 'Green Fluorescent Proteins', 'Guinea Pigs', 'Herpesvirus 1, Suid', 'In Vitro Techniques', 'Pancreatic Ducts', 'Pseudorabies'] | 16,273,613 | [['B01.050'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['D12.776.532.265'], ['B01.050.150.900.649.313.992.550'], ['B04.280.382.100.900.510'], ['E05.481'], ['A03.734.667'], ['C01.207.245.710', 'C01.925.182.710', 'C01.925.256.466.793', 'C10.228.228.245.710', 'C22.742']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells. | BACKGROUND: The lipogenesis-promoting enzyme fatty acid synthase is highly expressed in pancreatic ductal adenocarcinoma. Angiotensin II, which is the principal hormone of the renin angiotensin system, is generated actively in the pancreas and has been shown to increase the expression of fatty acid synthase. The angiot... | ['AMP-Activated Protein Kinases', 'Angiotensin II Type 2 Receptor Blockers', 'Carcinoma, Pancreatic Ductal', 'Cell Line, Tumor', 'Fatty Acid Synthases', 'Humans', 'Pancreatic Neoplasms', 'Receptor, Angiotensin, Type 2'] | 21,801,966 | [['D08.811.913.696.620.682.700.085', 'D12.644.360.062', 'D12.776.476.062'], ['D27.505.519.162.750'], ['C04.557.470.200.025.232.750', 'C04.557.470.615.132.750', 'C04.588.274.761.750', 'C04.588.322.475.750', 'C06.301.761.750', 'C06.689.667.625', 'C19.344.421.750'], ['A11.251.210.190', 'A11.251.860.180'], ['D08.811.277.35... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electron paramagnetic resonance crystallography of bacterial catalase: g-Contour mapping method of analysis. | Single crystals of bacterial catalase from Micrococcus luteus have been examined by EPR at 77 K. X-ray perfect crystals gave a set of four prominent resonances in all three orthogonal planes which yielded eight heme direction cosine matrices to an accuracy of +/- 2 degrees as expected for the P4(2)2(1)2 space group and... | ['Catalase', 'Crystallography', 'Electron Spin Resonance Spectroscopy', 'Heme', 'Micrococcus', 'Protein Conformation'] | 6,296,827 | [['D08.811.682.732.332'], ['E05.196.309', 'H01.181.529.240'], ['E05.196.867.519.274'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['B03.510.024.850.500', 'B03.510.400.500.500'], ['G02.111.570.820.709']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of antibiotics and steroids on the carriage of vaginal bacteria into the uterus during insertion of intra-uterine monofilaments in the guinea-pig. | The effects of systemic norethisterone acetate and oxytetracycline hydrochloride on the levels of vaginal microorganisms found in the uterus after the insertion of transcervical, intra-uterine monofilaments in the guinea-pig were determined. The results indicated that bacteria were transferred to the uterus from the va... | ['Animals', 'Bacteria', 'Colony Count, Microbial', 'Female', 'Guinea Pigs', 'Injections, Intraperitoneal', 'Intrauterine Devices', 'Norethindrone', 'Norethindrone Acetate', 'Oxytetracycline', 'Progesterone Congeners', 'Uterus', 'Vagina'] | 8,105,064 | [['B01.050'], ['B03'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B01.050.150.900.649.313.992.550'], ['E02.319.267.530.490'], ['E07.190.250.510'], ['D04.210.500.668.651.693.651'], ['D04.210.500.668.651.693.651.500'], ['D02.455.426.559.847.562.900.600', 'D04.615.562.900.600'], ['D06.472.334.851.687'], ['A05.360.319.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Involvement of the global regulator H-NS in the survival of Escherichia coli in stationary phase. | Long-term batch cultures of Escherichia coli grown in nutrient-rich medium accumulate mutations that provide a growth advantage in the stationary phase (GASP). We have examined the survivors of prolonged stationary phase to identify loci involved in conferring a growth advantage and show that a mutation in the hns gene... | ['Animals', 'Bacterial Proteins', 'Bacteriological Techniques', 'Chromosome Mapping', 'Chromosomes, Bacterial', 'Cloning, Molecular', 'Coculture Techniques', 'Escherichia coli', 'Escherichia coli Proteins', 'Fimbriae Proteins', 'Gene Deletion', 'Gene Expression Regulation, Bacterial', 'Protein Binding', 'Sigma Factor',... | 22,843,842 | [['B01.050'], ['D12.776.097'], ['E01.370.225.875.150', 'E05.200.875.150'], ['E05.393.183'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['E05.393.220'], ['E05.481.500.374'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D12.776.097.120.425', 'D12.776.543.100.300'], ['G05.365.590.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Myocardial perfusion in experimentally induced diabetes mellitus. | Diabetes mellitus was induced in rabbits by alloxan monohydrate. At the end of six-week period, animals of the control and diabetic groups (8 rabbits each) were sacrificed and their hearts were excised and perfused using Langendorff apparatus. Results revealed that diabetes had adverse effects on myocardial perfusion. ... | ['Animals', 'Coronary Circulation', 'Diabetes Mellitus, Experimental', 'Male', 'Rabbits'] | 2,365,422 | [['B01.050'], ['G09.330.100.324'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced protein phosphorylation in SV40-transformed and -infected cells. | We have studied the phosphorylation of cellular phosphoproteins and, in more detail, of SV40 T antigen and the cellular protein p53 in SV40 tsA-transformed cells. As detected by radiolabeling cold-sensitive tsA1499- or heat-sensitive tsA58-transformed rat fibroblasts with [32P]orthophosphate or by in vitro labeling ext... | ['Animals', 'Antigens, Viral, Tumor', 'Cell Transformation, Viral', 'Haplorhini', 'Mice', 'Mutation', 'Neoplasm Proteins', 'Phosphoproteins', 'Rats', 'Simian virus 40', 'Temperature', 'Tumor Suppressor Protein p53', 'Tumor Virus Infections'] | 2,821,683 | [['B01.050'], ['D23.050.285.062', 'D23.050.327.062'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['B01.050.150.900.649.313.988.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.365.590'], ['D12.776.624'], ['D12.776.744'], ['B01.050.150.900.649.313.992.635.505.700'], ['B04.280.210.700.615... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Interleukin-1â induces blood-brain barrier disruption by downregulating Sonic hedgehog in astrocytes. | The blood-brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglial activation are com... | ['Animals', 'Astrocytes', 'Blood-Brain Barrier', 'Cell Line', 'Chemokines', 'Down-Regulation', 'Gene Expression', 'Hedgehog Proteins', 'Interleukin-1beta', 'Mice', 'Paracrine Communication', 'Tight Junctions'] | 25,313,834 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['A07.035', 'A08.186.211.035'], ['A11.251.210'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.297'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['D12.644... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The immunology of experimental Chagas' disease. II. Delayed hypersensitivity to Trypanosoma cruzi antigens. | Homogenates of suspensions of the trypomastigote and amastigote forms of the Ernestina strain of Trypanosoma cruzi, derived from tissue cultures, yielded two subcellular fractions which elicited strong delayed hypersensitivity reactions in rabbits. The 100,000 g times 90 minute fraction of T. cruzi homogenates gave ris... | ['Animals', 'Antigens', 'Cell Migration Inhibition', 'Chagas Disease', 'Hypersensitivity, Delayed', 'Immunity, Cellular', 'Immunization, Passive', 'Lymphocyte Activation', 'Lymphocytes', 'Monocytes', 'Rabbits', 'Skin Tests', 'Subcellular Fractions', 'Trypanosoma cruzi'] | 805,088 | [['B01.050'], ['D23.050'], ['G04.198.337'], ['C01.610.752.300.900.200', 'C01.920.625'], ['C20.543.418'], ['G12.450.050.400'], ['E02.095.465.425.400.330', 'E05.478.550.520'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['A11.118.637.555.567', 'A15.145.229.637.555.567'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Culture-independent evaluation of nonenveloped-virus infectivity reduced by free-chlorine disinfection. | The inability of molecular detection methods to distinguish disinfected virions from infectious ones has hampered the assessment of infectivity for enteric viruses caused by disinfection practices. In the present study, the reduction of infectivity of murine norovirus S7-PP3 and mengovirus vMC0, surrogates of human nor... | ['Chlorine', 'Disinfectants', 'Mengovirus', 'Norovirus', 'Real-Time Polymerase Chain Reaction', 'Viral Plaque Assay'] | 25,681,178 | [['D01.268.380.150', 'D01.362.225'], ['D27.505.954.122.425', 'D27.720.274'], ['B04.820.578.750.170.200.500'], ['B04.820.578.298.550'], ['E05.393.620.500.706'], ['E01.370.225.875.970.790', 'E05.200.875.970.790']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multicenter evaluation of the commutability of a potential reference material for harmonization of enzyme activities. | Standardization of laboratory results allows for the use of common reference intervals and can be achieved via calibration of field methods with secondary reference materials. These harmonization materials should be commutable, i.e., they produce identical numerical results independent of assay principle or platform. T... | ['Blood Specimen Collection', 'Catalysis', 'Clinical Enzyme Tests', 'Enzymes', 'Humans', 'Linear Models', 'Reference Standards', 'Sensitivity and Specificity', 'Sucrose'] | 15,576,303 | [['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['G02.130'], ['E01.370.225.124.200', 'E05.196.427.200', 'E05.200.124.200'], ['D08.811'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Localization of ischemia in canine hearts using tagged rotated long axis MR images, endocardial surface stretch and wall thickening. | Tagged magnetic resonance imaging allows the noninvasive measurement of regional systolic myocardial deformations and helps localize ischemic regions in the left ventricle (LV). The objective of this study was to evaluate the potential accuracy of localizing ischemic regions in the LV using endocardial and epicardial d... | ['Animals', 'Dogs', 'Evaluation Studies as Topic', 'Heart Ventricles', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Models, Cardiovascular', 'Models, Structural', 'Myocardial Contraction', 'Myocardial Ischemia', 'Sensitivity and Specificity', 'Stress, Mechanical', 'Systole'] | 9,364,950 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.337', 'N05.715.360.335'], ['A07.541.560'], ['L01.224.308'], ['E01.370.350.825.500'], ['E05.599.395.161'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['G09.330.580', 'G11.427.494.570'], ['C14.280.647', 'C14.907.585'], ['E05.318.370.800', 'E05.318.740.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Intranuclear delivery of an antiviral peptide mediated by the B subunit of Escherichia coli heat-labile enterotoxin. | We report an intracellular peptide delivery system capable of targeting specific cellular compartments. In the model system we constructed a chimeric protein consisting of the nontoxic B subunit of Escherichia coli heat-labile enterotoxin (EtxB) fused to a 27-mer peptide derived from the DNA polymerase of herpes simple... | ['3T3 Cells', 'Amino Acid Sequence', 'Animals', 'Antiviral Agents', 'Bacterial Toxins', 'COS Cells', 'Chlorocebus aethiops', 'DNA-Directed DNA Polymerase', 'Drug Delivery Systems', 'Enterotoxins', 'Escherichia coli', 'Escherichia coli Proteins', 'Herpes Simplex', 'Herpesvirus 1, Human', 'Mice', 'Molecular Sequence Data... | 10,220,447 | [['A11.251.210.100', 'A11.329.228.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D27.505.954.122.388'], ['D23.946.123'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D08.811.913.696.445.308.300'], ['E02.319.300'], ['D23.946.330'], ['B03.440.45... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification and characterization of two flavohemoglobin genes in Dictyostelium discoideum. | Flavohemoglobins are being identified in an expanding number of prokaryotes and unicellular eukaryotes. These molecules consist of an N-terminal hemoglobin domain and a C-terminal oxidoreductase domain, and are considered to function in storage or as sensors for O2, and in defense against oxidative stress and/or NO. Ho... | ['Amino Acid Sequence', 'Animals', 'Bacterial Proteins', 'Base Sequence', 'DNA, Complementary', 'Dictyostelium', 'Hemeproteins', 'Molecular Sequence Data', 'Oxidoreductases', 'Sequence Homology, Amino Acid'] | 10,791,894 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.046.550.200.300'], ['D12.776.422'], ['L01.453.245.667'], ['D08.811.682'], ['G02.111.810.200', 'G05.81... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Excretory/secretory products of plerocercoids of Spirometra erinaceieuropaei induce the expression of inducible nitric oxide synthase mRNA in murine hepatocytes. | In this study, we observed the level of normal murine hepatocyte inducible NOS (iNOS) mRNA by semi-quantitative polymerase chain reaction (SQ-PCR) analysis after stimulation with ES products (ESP) and/or ESP fractions from the plerocercoids. We found that ESP are able to induce the expression of iNOS gene in a dose-dep... | ['Animals', 'Cells, Cultured', 'Cycloheximide', 'Dactinomycin', 'Dexamethasone', 'Enzyme Induction', 'Gene Expression Regulation', 'Interferon-gamma', 'Lipopolysaccharides', 'Liver', 'Male', 'Mice', 'Mice, Inbred ICR', 'Nitric Oxide Synthase', 'RNA, Messenger', 'Spirometra'] | 9,184,928 | [['B01.050'], ['A11.251'], ['D03.383.621.808.240'], ['D03.633.300.200', 'D04.345.566.252', 'D12.644.641.252'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G05.308.320.200'], ['G05.308'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pseudo-occlusions of the internal carotid artery: a rationale for treatment on the basis of a modified carotid duplex scan protocol. | PURPOSE: We report on a modified duplex scanning technique that may be a means of detecting a patent internal carotid artery (ICA) previously believed to be occluded by means of magnetic resonance angiography (MRA), standard duplex protocols, or both. In addition, we attempted to develop selection criteria for operabil... | ['Aged', 'Aged, 80 and over', 'Blood Flow Velocity', 'Carotid Artery, Internal', 'Carotid Stenosis', 'Combined Modality Therapy', 'Endarterectomy, Carotid', 'Female', 'Follow-Up Studies', 'Heart Failure', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'New York', 'Postoperative Complications', 'Survival An... | 11,854,733 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.370.130', 'G09.330.380.630.080'], ['A07.015.114.186.200.230'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E02.186'], ['E04.100.814.456.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ethics report on interspecies somatic cell nuclear transfer research. | This report considers whether research involving the creation of human-animal interspecies somatic cell nuclear transfer (iSCNT) embryos raises new ethical issues, and if so, whether it requires additional or special criteria and oversight distinct from research on human-animal chimeras. | ['Biomedical Research', 'Blastocyst', 'Embryo Culture Techniques', 'Embryonic Development', 'Embryonic Stem Cells', 'Genetic Research', 'Humans', 'Nuclear Transfer Techniques'] | 19,570,511 | [['H01.770.644.145'], ['A16.254.500'], ['E05.481.500.468'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['A11.872.700.250'], ['H01.158.273.343.249', 'H01.770.644.145.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.200.500.380.500', 'E05.393.085.500', 'E05.820.540']] | ['Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Apraclonidine attenuates the increases in spinal excitatory amino acid release in rats with adjuvant-induced inflammation. | UNLABELLED: The release of excitatory amino acids (EAAs), nitric oxide, and prostaglandins plays a critical role in the development of peripheral tactile and thermal hypersensitivity after the induction of knee joint inflammation. In this study, we used a model of chronic spinal microdialysis to examine the effect of c... | ['Adrenergic alpha-2 Receptor Agonists', 'Adrenergic alpha-Agonists', 'Animals', 'Arthritis, Experimental', 'Clonidine', 'Excitatory Amino Acids', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Spinal Cord'] | 11,867,401 | [['D27.505.519.625.050.100.100.200', 'D27.505.696.577.050.100.100.200'], ['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['B01.050'], ['C05.550.114.015', 'E05.598.500.249'], ['D03.383.129.308.436.500'], ['D12.125.427'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of adolescence and advanced maternal age on the incidence of complete and partial molar pregnancy. | OBJECTIVE: To compare the age-specific incidence of complete (CM) and partial molar (PM) pregnancy in a large tertiary care center in the United States.METHODS: Incidence rates of CM and PM per 10,000 live births were calculated using databases from Brigham and Women's Hospital, between 2000 and 2013. Age-specific rate... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Hydatidiform Mole', 'Incidence', 'Maternal Age', 'Pregnancy', 'United States', 'Young Adult'] | 26,777,992 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.955.416.812', 'C04.850.908.416.750', 'C13.703.720.949.416.875'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['G08.686.560', 'N05.715.350.075.550', 'N06... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. | Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation and anti-metastasis properties. Herein, GAEE, G. lucidum extract mainly contains gan... | ['Actins', 'Apoptosis', 'Breast Neoplasms', 'Cell Adhesion', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Movement', 'Female', 'Focal Adhesion Protein-Tyrosine Kinases', 'Humans', 'Paxillin', 'Phosphorylation', 'Polysaccharides', 'Protein Binding', 'Signal Transduction', 'rho GTP-Binding Proteins', 'src-Family K... | 24,204,647 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['G04.146.954.035'], ['C04.588.180', 'C17.800.090.500'], ['G04.022'], ['G04.144.109'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['D08.811.913.696.620.682.725.049', 'D12.644.360.287', 'D12.776.476.287'], ['B01.050.150.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preliminary development and evaluation of online tobacco and alcohol modules for dental students. | Tobacco use and heavy alcohol consumption are major risk factors for the development of oral and pharyngeal cancer (OPC). Detection and modification of these risks by dentists are keys in preventing OPC. While dentists are encouraged to screen patients for tobacco and alcohol use and educate them about the oral health ... | ['Alcohol Drinking', 'Computer-Assisted Instruction', 'Curriculum', 'Education, Dental', 'Education, Distance', 'Feasibility Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Linear Models', 'Male', 'Mass Screening', 'Mouth Neoplasms', 'Oropharyngeal Neoplasms', 'Pilot Projects', 'Program Developm... | 21,642,525 | [['F01.145.317.269'], ['I02.903.771.500.208'], ['I02.158'], ['I02.358.274'], ['I02.195'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835... | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Retinal photoreceptors of Syrian hamsters undergo oxidative stress during streptozotocin-induced diabetes. | AIMS/HYPOTHESIS: The aim of this study was to verify whether retinal photoreceptors, like other tissues, are subject to oxidative stress during diabetes.METHODS: Oxidative stress was monitored by the oxidation of preloaded dehydrorhodamine 123 into fluorescent rhodamine 123, during a period of intense illumination of i... | ['Amidines', 'Animals', 'Antioxidants', 'Blood Glucose', 'Body Weight', 'Cholesterol', 'Cricetinae', 'Diabetes Mellitus, Experimental', 'Fluorescent Dyes', 'Kinetics', 'Light', 'Lipid Peroxidation', 'Melatonin', 'Mesocricetus', 'Oxidants', 'Oxidative Stress', 'Photoreceptor Cells, Vertebrate', 'Triglycerides'] | 11,845,231 | [['D02.078'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['B01.050... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oral health status of the disabled compared with that of the non-disabled in Korea: A propensity score matching analysis. | BACKGROUND: There are many types of disabilities, and each type has a variety related to socioeconomic factors. Such factors affect to many health problems of the disabled. However, surveys of the oral health status of the disabled in Korea are rare.OBJECTIVE: The purpose of this study was to estimate oral health dispa... | ['Adult', 'Age Distribution', 'Dental Caries', 'Disabled Persons', 'Female', 'Humans', 'Logistic Models', 'Male', 'Mouth, Edentulous', 'Multivariate Analysis', 'Oral Health', 'Propensity Score', 'Republic of Korea', 'Risk Factors'] | 30,640,962 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C07.793.720.210'], ['M01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. | tRNA isopentenylation is a branch of an isoprenoid pathway in yeast. There is a competition for a substrate between isoprenoid biosynthetic enzyme Erg20p and tRNA isopentenyltransferase. Here we studied the direct effect of elevated tRNA biosynthesis on ERG20 expression. The maf1-1 mutant of Saccharomyces cerevisiae th... | ['Alkyl and Aryl Transferases', 'Blotting, Northern', 'Ergosterol', 'Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Mutation', 'Polyisoprenyl Phosphates', 'RNA, Transfer', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Transcription Factors'] | 12,702,319 | [['D08.811.913.225'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D04.210.500.247.222.537'], ['D12.776.354'], ['G05.308.330'], ['G05.365.590'], ['D02.455.849.690', 'D02.705.400.725'], ['D13.444.735.757'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750'], ['D12.776.930']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrophysiological properties of human adipose tissue-derived stem cells. | Human adipose tissue-derived stem cells (hASCs) represent a potentially valuable cell source for clinical therapeutic applications. The present study was designed to investigate properties of ionic channel currents present in undifferentiated hASCs and their impact on hASCs proliferation. The functional ion channels in... | ['Adipose Tissue', 'Adult Stem Cells', 'Blotting, Western', 'Cell Differentiation', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Delayed Rectifier Potassium Channels', 'Dose-Response Relationship, Drug', 'Humans', 'Membrane Potentials', 'Patch-Clamp Techniques', 'Potassium', 'Potassium Channel Blockers', ... | 17,687,001 | [['A10.165.114'], ['A11.872.040'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['D12.776.157.530.400.600.900.124', 'D12.776.543.550.450.750.900.124', 'D12.776.543.585.400.750.900.124']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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