Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Sow communication with piglets while being active is a good predictor of maternal skills, piglet survival and litter quality in three different breeds of domestic pigs (Sus scrofa domesticus). | Maternal care behaviour is crucial for offspring quality and survival in pigs. Defining care is therefore essential for ensuring the welfare of pigs and sustainability of pig production. The aim of the present study was to investigate the relationship between sow nest building, communication with piglets (sniffing, nud... | ['Animals', 'Animals, Newborn', 'Female', 'Housing, Animal', 'Lactation', 'Litter Size', 'Maternal Behavior', 'Meat', 'Pregnancy', 'Stillbirth', 'Sus scrofa', 'Weaning'] | 30,427,860 | [['B01.050'], ['B01.050.050.282'], ['J03.340.250', 'N06.230.150.360.250'], ['G08.686.523', 'G08.686.702.500'], ['G08.686.530', 'G08.686.784.769.498.300'], ['F01.829.263.370.215'], ['G07.203.300.600', 'J02.500.600'], ['G08.686.784.769'], ['C13.703.223.650', 'C23.550.260.585.630', 'G08.686.784.769.496.500'], ['B01.050.15... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Effects of magnesium sulfate on neuromuscular function and spontaneous breathing during sevoflurane and spinal anesthesia. | The purpose of the present study was to determine the effects of magnesium sulfate (MgSO(4)) on the neuromuscular function and spontaneous breathing of patients under sevoflurane and spinal anesthesia. Twenty-two patients with a history of arrhythmia undergoing elective knee surgery were randomly assigned to two groups... | ['Aged', 'Aged, 80 and over', 'Anesthesia, Spinal', 'Anesthetics', 'Anesthetics, Combined', 'Anesthetics, Inhalation', 'Arrhythmias, Cardiac', 'Blood Gas Analysis', 'Blood Pressure', 'Elective Surgical Procedures', 'Female', 'Heart Rate', 'Humans', 'Knee Joint', 'Magnesium Sulfate', 'Male', 'Methyl Ethers', 'Middle Age... | 17,285,423 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E03.155.086.331'], ['D27.505.696.277.100', 'D27.505.954.427.210.100'], ['D27.505.696.277.100.017', 'D27.505.954.427.210.100.017'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['C14.280.067', 'C23.550.073'], ['E01.370.225.124.100.100', 'E01.370.386... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Use of apparatus POOS-I for determination of the DNA concentration of lymphoid tissue]. | Using the apparatus "POOS-I" (a device for measuring the reflecting power) the author carried out microspectrophotometric determination of the DNA content in the lymphoid tissue of mice following gamma-irradiation and transplantation of the syngenic and allogenic bone marrow. An amount of DNA was expressed as a relativ... | ['Animals', 'Bone Marrow', 'Bone Marrow Cells', 'DNA', 'Lymph Nodes', 'Male', 'Mice', 'Radiation Injuries, Experimental', 'Spectrophotometry'] | 1,225,278 | [['B01.050'], ['A15.382.216'], ['A11.148', 'A15.378.316'], ['D13.444.308'], ['A10.549.400', 'A15.382.520.604.412'], ['B01.050.150.900.649.313.992.635.505.500'], ['C26.733.720', 'E05.598.500.750', 'G01.750.748.500.720', 'N06.850.460.350.850.500.285', 'N06.850.810.300.360.285'], ['E05.196.712.726', 'E05.196.867.826']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Treatment strategy for metastatic prostate cancer with extremely high PSA level: reconsidering the value of vintage therapy. | The prognostic significance of initial prostate-specific antigen (PSA) level for metastatic prostate cancer remains uncertain. We investigated the differences in prognosis and response to hormonal therapies of metastatic prostate cancer patients according to initial PSA levels. We analyzed 184 patients diagnosed with m... | ['Aged', 'Aged, 80 and over', 'Androgen Antagonists', 'Disease Progression', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Progression-Free Survival', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Treatment Outcome'] | 29,735,818 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D06.347.065', 'D27.505.696.399.450.065'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['E01.789.800.285', 'E05.318.740.998.738', 'N04.761.559.590.800.474', 'N05.715.360.575.575.800.474', 'N05.715.360.750.795.738... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Serum levels of growth hormone-binding protein and insulin-like growth factor-I during puberty. | OBJECTIVE: The aim was to investigate the effect of pubertal development on serum levels of growth hormone binding protein (GHBP) and IGF-I, and to study the relationship between GHBP levels and height standard deviation score (SDS), nutritional state and IGF-I levels.DESIGN AND PATIENTS: The investigation was performe... | ['Adolescent', 'Adult', 'Body Height', 'Body Weight', 'Carrier Proteins', 'Child', 'Child, Preschool', 'Chromatography, High Pressure Liquid', 'Cross-Sectional Studies', 'Female', 'Growth Hormone', 'Humans', 'Insulin-Like Growth Factor I', 'Male', 'Nutritional Status', 'Puberty', 'Radioimmunoassay'] | 1,395,068 | [['M01.060.057'], ['M01.060.116'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D12.776.157'], ['M01.060.406'], ['M01.060.406.448'], ['E05.196.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A correlation between phorbol diester-induced protein phosphorylation and superoxide anion generation in HL-60 cells during granulocytic maturation. | As HL-60 cells matured along the granulocytic pathway, phorbol diester-induced superoxide anion production was compared to phorbol diester-induced protein phosphorylation using an in vitro phosphorylation technique. Maturation was induced by 0, 2, 4, or 6 days incubation with dimethyl sulfoxide (Me2SO). In 0 day Me2SO ... | ['Cell Differentiation', 'Cell Line', 'Dimethyl Sulfoxide', 'Granulocytes', 'Humans', 'Kinetics', 'Leukemia, Myeloid, Acute', 'Molecular Weight', 'Neoplasm Proteins', 'Phosphoproteins', 'Phosphorylation', 'Protein Kinase C', 'Superoxides', 'Tetradecanoylphorbol Acetate'] | 3,027,071 | [['G04.152'], ['A11.251.210'], ['D02.886.640.150'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['C04.557.337.539.275'], ['G02.494'], ['D12.776.624'], ['D12.776.744'], ['G... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system. | Immunopotentiation on oral feeding of standardized aqueous extract of Withania somnifera (Linn. Dunal, Family Solanaceae) was evaluated in laboratory animals immunized with DPT (Diphtheria, Pertussis, Tetanus) vaccine. The immunostimulation was evaluated using serological and hematological parameters. Treatment of immu... | ['Animals', 'Antibodies, Bacterial', 'Blood Cell Count', 'Chromatography, Thin Layer', 'Diphtheria-Tetanus-Pertussis Vaccine', 'Female', 'Immunologic Factors', 'Male', 'Mice', 'Plant Extracts', 'Plant Roots', 'Water', 'Whooping Cough', 'Withania'] | 15,135,324 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['E05.196.181.400.537'], ['D20.215.894.135.535.300', 'D20.215.894.69... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevention of postoperative urinary retention after total hip arthroplasty in male patients. | The efficacy of phenoxybenzamine in preventing postoperative urinary retention after total hip arthroplasty was investigated in a double-blind placebo-controlled study on 60 consecutive male patients with obstructive urinary symptoms. The patients were randomized into two groups, one being given 10 mg phenoxybenzamine ... | ['Aged', 'Clinical Trials as Topic', 'Double-Blind Method', 'Hip Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Phenoxybenzamine', 'Postoperative Complications', 'Urination Disorders'] | 3,314,645 | [['M01.060.116.100'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.092.471.739'], ['C23.550.767'], ['C1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The Women's Recovery Group Study: a Stage I trial of women-focused group therapy for substance use disorders versus mixed-gender group drug counseling. | The aim of this Stage I Behavioral Development Trial was to develop a manual-based 12-session Women's Recovery Group (WRG) and to pilot test this new treatment in a randomized controlled trial against a mixed-gender Group Drug Counseling (GDC), an effective manual-based treatment for substance use disorders. After init... | ['Adult', 'Aged', 'Alcohol-Related Disorders', 'Central Nervous System Stimulants', 'Cocaine-Related Disorders', 'Cognitive Behavioral Therapy', 'Counseling', 'Female', 'Follow-Up Studies', 'Gender Identity', 'Humans', 'Male', 'Marijuana Abuse', 'Middle Aged', 'Pilot Projects', 'Psychotherapy, Group', 'Secondary Preven... | 17,446,014 | [['M01.060.116'], ['M01.060.116.100'], ['C25.775.100', 'F03.900.100'], ['D27.505.696.282', 'D27.505.954.427.220'], ['C25.775.300', 'F03.900.300'], ['F04.754.137.350'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.75... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Serum folic acid levels in epileptic mothers and their relationship to congenital malformations. | Folic acid levels during pregnancy and in pre-pregnancy were determined in 51 epileptic mothers and those of matched controls. The serum folic acid (SF) levels of epileptic mothers were significantly lower than those of controls in all study periods. The SF levels of mothers of malformed offspring were significantly lo... | ['Abnormalities, Drug-Induced', 'Adult', 'Anticonvulsants', 'Epilepsy', 'Female', 'Folic Acid', 'Humans', 'Pregnancy', 'Pregnancy Complications', 'Reference Values'] | 2,060,505 | [['C16.131.042'], ['M01.060.116'], ['D27.505.954.427.080'], ['C10.228.140.490'], ['D03.633.100.733.631.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C13.703'], ['E05.978.810']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. | Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a phase I trials clinic. TARGET is a molecular profiling program with the primary aim to match patients with a broad range of advanced cancers to early phase cl... | ['Biomarkers, Tumor', 'Circulating Tumor DNA', 'Clinical Trials, Phase I as Topic', 'DNA Copy Number Variations', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Mutation', 'Neoplasms', 'Patient Selection', 'Sequence Analysis, DNA'] | 31,011,204 | [['D23.101.140'], ['D13.444.154.500', 'D13.444.308.425.500'], ['E05.318.372.250.250.200', 'N05.715.360.330.250.250.200', 'N06.850.520.450.250.250.200'], ['G05.365.795.297.500'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['C04'], ['E05.581.500.653', 'N04.590.731'], ['E05.393.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An Investigation Into Vortioxetine Salts: Crystal Structure, Thermal Stability, and Solubilization. | Three 1:1 salts containing vortioxetine (VOT), an orally antidepressant drug, and 3 aryl monoacids have been designed and successfully prepared by liquid-assisted grinding based on the ÄpKa rule. The C-O bond lengths (?1.25 ?) in the COOH groups show that the proton transfer has occurred from aryl monoacid to piperazin... | ['Aminobenzoates', 'Antidepressive Agents', 'Calorimetry, Differential Scanning', 'Chromatography, High Pressure Liquid', 'Crystallization', 'Crystallography, X-Ray', 'Drug Compounding', 'Drug Stability', 'Hot Temperature', 'Hydrogen Bonding', 'Magnetic Resonance Spectroscopy', 'Piperazines', 'Salts', 'Solubility', 'Sp... | 27,262,207 | [['D02.241.223.100.050', 'D02.455.426.559.389.127.020'], ['D27.505.954.427.700.122'], ['E05.196.131.310', 'E05.196.370.310'], ['E05.196.181.400.300'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['E05.916.270'], ['E05.916.330'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The effect of different concentrations of water soluble azadirachtin (neem metabolite) on Streptococcus mutans compared with chlorhexidine. | UNLABELLED: Despite advances in the development of anticaries chemotherapy, the newer agents are unable to control the initiation of dental caries. Research and development of natural antibacterial agents that are safe for the host as well as specific for oral pathogens is awaited. Neem tree extracts have been used for... | ['Anti-Infective Agents', 'Child', 'Chlorhexidine', 'Dental Plaque', 'Female', 'Humans', 'Insecticides', 'Limonins', 'Male', 'Microbial Sensitivity Tests', 'Stem Cells', 'Streptococcus mutans'] | 27,080,957 | [['D27.505.954.122'], ['M01.060.406'], ['D02.078.370.141.100'], ['C07.793.208.377'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.031.700.491', 'D27.888.723.491'], ['D02.455.849.919.490'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['A11.872'], ['B03.353.750.737.872.875.520', 'B03.510.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dynamic change in the expression of developmental genes in the ascidian central nervous system: revisit to the tripartite model and the origin of the midbrain-hindbrain boundary region. | Comparative studies on expression patterns of developmental genes along the anterior-posterior axis of the embryonic central nervous system (CNS) between vertebrates and ascidians led to the notion of "tripartite organization," a common ground plan of the CNS, consisting of the anterior, central and posterior regions e... | ['Animals', 'Body Patterning', 'Central Nervous System', 'Ciona intestinalis', 'Gene Expression Regulation, Developmental', 'Genes, Developmental', 'Mesencephalon', 'Neurons', 'Rhombencephalon'] | 17,996,862 | [['B01.050'], ['G07.345.500.100'], ['A08.186'], ['B01.050.150.200.727.150.500', 'B01.050.500.272.727.150.500'], ['G05.308.310'], ['G05.360.340.024.340.230'], ['A08.186.211.132.659'], ['A08.675', 'A11.671'], ['A08.186.211.132.810']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[ICD-10 adaptation of 15 Agency for Healthcare Research and Quality patient safety indicators]. | BACKGROUND: In the United States, the Agency for Healthcare Research and Quality (AHRQ) has developed 20 Patient Safety Indicators (PSIs) to measure the occurrence of hospital adverse events from medico-administrative data coded according to the ninth revision of the international classification of disease (ICD-9-CM). ... | ['Algorithms', 'Clinical Coding', 'Diagnosis-Related Groups', 'France', 'Health Systems Agencies', 'Humans', 'International Classification of Diseases', 'International Cooperation', 'Patient Safety', 'Quality Indicators, Health Care', 'Terminology as Topic', 'United States', 'United States Agency for Healthcare Researc... | 21,899,967 | [['G17.035', 'L01.224.050'], ['N04.452.758.708.200.400.500', 'N04.452.859.564.274', 'N05.715.360.300.715.500.249', 'N06.850.520.308.940.968.249'], ['N03.219.521.710.305.200.080'], ['Z01.542.286'], ['N03.540.452.508.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.945.400'], ['I01.615.500'], ['N06.8... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Evaluation of normal appendix vermiformis in adults with multidetector computed tomography. | To determine the utility of different contrast enhancement phases (unenhanced, arterial, and venous), slice thicknesses (0.5, 3, and 5 mm), and planes (axial and coronal) in the evaluation of appendix vermiformis (AV) on multidetector computed tomography (MDCT), CT examinations of 600 patients were obtained. No signifi... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Algorithms', 'Appendix', 'Contrast Media', 'Female', 'Humans', 'Male', 'Middle Aged', 'Radiographic Image Enhancement', 'Radiographic Image Interpretation, Computer-Assisted', 'Radiography, Abdominal', 'Reference Values', 'Reproducibility of Results', 'Sensitivity a... | 23,154,006 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['A03.556.124.526.209.290', 'A03.556.249.249.209.290'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.600.350.700', 'E01.370.350.700.700'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A Rasch-based validation of a short version of ABILHAND as a measure of manual ability in adults with unilateral upper limb amputation. | PURPOSE: To evaluate the measurement properties of ABILHAND (a generic measure developed to assess functioning in people with upper limb impairments) when used in adults with unilateral upper limb amputation (ULA).METHODS: A convenience sample of 72 adults who had unilateral ULA and completed rehabilitation at the Inst... | ['Adult', 'Aged', 'Aged, 80 and over', 'Amputees', 'Disability Evaluation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Motor Skills', 'Psychometrics', 'Recovery of Function', 'Surveys and Questionnaires', 'Upper Extremity'] | 19,874,081 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.150.100'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.808.260'], ['F04.711.780'], ['G16.757'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['A01.378.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chronic intestinal inflammation alters hippocampal neurogenesis. | BACKGROUND: Adult neurogenesis in the subgranular zone of the hippocampus is involved in learning, memory, and mood control. Decreased hippocampal neurogenesis elicits significant behavioral changes, including cognitive impairment and depression. Inflammatory bowel disease (IBD) is a group of chronic inflammatory condi... | ['Animals', 'Cells, Cultured', 'Chronic Disease', 'Cytokines', 'Dextran Sulfate', 'Disease Models, Animal', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Gastroenteritis', 'Hippocampus', 'Ki-67 Antigen', 'Mice', 'Mice, Inbred C57BL', 'Nerve Tissue Proteins', 'Neural Stem Cells', 'Neurogenesis', 'RNA, Messenger', 'Sta... | 25,889,852 | [['B01.050'], ['A11.251'], ['C23.550.291.500'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D09.698.365.272.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['C06.405.205'], ['A08.186.2... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Leukocyte recruitment after local endobronchial allergen challenge in asthma. Relationship to procedure and to airway interleukin-8 release. | We have investigated the profile of cellular recruitment into asthmatic airways after allergen and saline exposure and its relationship to interleukin-8 (IL-8) release. Fiberoptic bronchoscopy was used to instill allergen into the middle lobe while the right upper lobe received a sham saline challenge. Bronchoalveolar ... | ['Adult', 'Albumins', 'Allergens', 'Asthma', 'Bronchial Provocation Tests', 'Bronchoalveolar Lavage Fluid', 'Bronchoscopy', 'Case-Control Studies', 'Cell Count', 'Enzyme-Linked Immunosorbent Assay', 'Eosinophils', 'Female', 'Humans', 'Interleukin-8', 'Male', 'Neutrophils', 'Time Factors'] | 8,756,824 | [['M01.060.116'], ['D12.776.034'], ['D23.050.063'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E01.370.386.700.125'], ['E05.927.100.500'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.45... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Certain effects of adenoidectomy of Eustachian tube ventilatory function. | In an effort to develop a simple and accurate method to identify children in whom adenoidectomy might prevent otitis media, the ventilatory function of the Eustachian tube was assessed by a manometric technique. Nasal pressures during swallowing were also determined in some. The study group consisted of 23 children wit... | ['Adenoidectomy', 'Child', 'Child, Preschool', 'Clinical Trials as Topic', 'Eustachian Tube', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Male', 'Manometry', 'Otitis Media', 'Pressure'] | 1,089,852 | [['E04.580.068'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['A09.246.397.369'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.559'], ['C09.218.705.663'], ['G01.374.715']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The properties and contribution of the Corynebacterium glutamicum MscS variant to fine-tuning of osmotic adaptation. | Based on sequence similarity, the mscCG gene product of Corynebacterium glutamicum belongs to the family of MscS-type mechanosensitive channels. In order to investigate the physiological significance of MscCG in response to osmotic shifts in detail, we studied its properties using both patch-clamp techniques and betain... | ['Adaptation, Physiological', 'Amino Acid Sequence', 'Bacterial Proteins', 'Carrier Proteins', 'Corynebacterium glutamicum', 'Ion Channels', 'Molecular Sequence Data', 'Symporters', 'Water-Electrolyte Balance'] | 20,599,688 | [['G07.025', 'G16.012.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['D12.776.157'], ['B03.510.024.250.300', 'B03.510.460.400.400.200.300'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['L01.453.245.667'], ['D12.776.157.530.450.625', 'D12.776.543.585.450.625'], ['G02.111... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Detection of bacteria using fluorogenic DNAzymes. | Outbreaks linked to food-borne and hospital-acquired pathogens account for millions of deaths and hospitalizations as well as colossal economic losses each and every year. Prevention of such outbreaks and minimization of the impact of an ongoing epidemic place an ever-increasing demand for analytical methods that can a... | ['Bacteriological Techniques', 'DNA, Catalytic', 'Escherichia coli', 'Fluorescent Dyes', 'RNA, Bacterial', 'SELEX Aptamer Technique', 'Spectrometry, Fluorescence'] | 22,688,431 | [['E01.370.225.875.150', 'E05.200.875.150'], ['D08.811.165', 'D08.811.913.696.445.735.265', 'D13.444.308.243'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D13.444.735.473'], ['E05.197.312.500', 'J01.897.836.249.249.500'], ['E05.196.712.516.600.676', 'E05.19... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington's disease mutation. | Huntington's disease (HD) is a progressive neurological disorder characterised by motor impairments caused by degeneration in the striatum. The mechanism by which the HD mutation leads to the neurodegenerative pathology of HD is still unknown. Recently it was shown that, in HD patients, early pathological changes in wh... | ['Animals', 'Axons', 'Brain', 'Disease Models, Animal', 'Disease Progression', 'Huntington Disease', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred CBA', 'Mice, Neurologic Mutants', 'Mice, Transgenic', 'Microscopy, Electron, Transmission', 'Muscle, Skeletal', 'Muscular Atrophy', 'Nerve Fibers, Myelinated', 'Neuromuscular ... | 18,062,944 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['C10.228.140.079.545', 'C10.228.140.380.278', 'C10.228.662.262.249.750', 'C10.574.500.497', 'C16.320.400.430', 'F03.615.250.400', 'F03.615.400.390... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multifocal osteomyelitis due to Mycobacterium szulgai in a patient with chronic lymphocytic leukemia. | Mycobacterium szulgai is a pathogenic organism that most frequently causes pulmonary infection and may rarely result in disseminated disease in immunocompromised individuals. We report a case of multifocal osteomyelitis and cutaneous lesions due to M. szulgai in a patient with chronic lymphocytic leukemia. The successf... | ['Aged', 'Antitubercular Agents', 'Drug Therapy, Combination', 'Ethambutol', 'Female', 'Humans', 'Isoniazid', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Mycobacterium Infections, Nontuberculous', 'Nontuberculous Mycobacteria', 'Osteomyelitis', 'Rifampin'] | 18,199,481 | [['M01.060.116.100'], ['D27.505.954.122.085.255'], ['E02.319.310'], ['D02.092.782.258.368.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['C04.557.337.428.080.125', 'C15.604.515.560.080.125', 'C20.683.515.528.080.125'], ['C01.150.252.410.040.552.475'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Determinants of the nurses' and nursing assistants' request for antipsychotics for people with dementia. | BACKGROUND: Although physicians are responsible for writing the antipsychotic prescriptions for patients with dementia, the initiative is often taken by nurses or nursing assistants. To reduce antipsychotics uses, one needs to understand the reasons for nurses and nursing assistants to request them. This study gives an... | ['Adult', 'Antipsychotic Agents', 'Attitude of Health Personnel', 'Decision Making', 'Dementia', 'Drug Prescriptions', 'Female', 'Humans', 'Job Satisfaction', 'Linear Models', 'Male', 'Middle Aged', 'Netherlands', "Nurse's Role", 'Nursing Assistants', 'Nursing Homes', 'Nursing Staff', 'Surveys and Questionnaires'] | 27,866,485 | [['M01.060.116'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['F01.100.050', 'N05.300.100'], ['F02.463.785.373'], ['C10.228.140.380', 'F03.615.400'], ['E02.319.307', 'N02.421.668.778.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['E05.318.74... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
On the threshold: how relevant should quantity be in determining intent to supply? | BACKGROUND: In 2005, the English Government announced plans to introduce thresholds into drugs legislation with a view to simplifying proof of intent to supply.METHODS: During the consultation process, the proposal was vigorously attacked as unjust and impractical. Drawing upon European and international experience, th... | ['Crime', 'Drug and Narcotic Control', 'Government Regulation', 'Humans', 'Intention', 'Law Enforcement', 'Policy Making', 'Prisons', 'Substance-Related Disorders', 'United Kingdom'] | 17,889,520 | [['I01.198.240', 'I01.880.735.191'], ['I01.880.604.605.250', 'N03.706.615.402.250', 'N04.452.706.310'], ['I01.880.604.394', 'N03.706.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658.650', 'F02.463.306'], ['I01.880.604.594'], ['N03.706.742'], ['I01.880.604.787', 'J03.220.500'], ['C25.775', 'F03.900'], [... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Synthesis, X-ray Single Crystal Structure, Molecular Docking and DFT Computations on N-[(1E)-1-(2H-1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]-hydroxylamine: A New Potential Antifungal Agent Precursor. | Mycoses are serious health problem, especially in immunocompromised individuals. A new imidazole-bearing compound containing an oxime functionality was synthesized and characterized with different spectroscopic techniques to be used for the preparation of new antifungal agents. The stereochemistry of the oxime double b... | ['Antifungal Agents', 'Crystallography, X-Ray', 'Hydrogen Bonding', 'Hydroxylamines', 'Imidazoles', 'Models, Molecular', 'Molecular Docking Simulation', 'Quantum Theory'] | 28,264,518 | [['D27.505.954.122.136'], ['E05.196.309.742.225'], ['G02.282'], ['D02.092.570'], ['D03.383.129.308'], ['E05.599.595'], ['E05.599.595.249', 'L01.224.160.249'], ['H01.671.579.800']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs. | Methylation of the exocyclic amino group of guanine is a relatively common modification in rRNA and tRNA. Single methylation (N(2)-methylguanosine, m(2)G) is the second most frequently encountered nucleoside analog in Escherichia coli rRNAs. The most prominent case of dual methylation (N(2),N(2)-dimethylguanosine, m(2)... | ['Adenine', 'Base Pair Mismatch', 'Base Pairing', 'Crystallography, X-Ray', 'Guanosine', 'Hydrogen Bonding', 'Methylation', 'Nucleic Acid Conformation', 'RNA', 'RNA Stability', 'Transition Temperature', 'Ultraviolet Rays'] | 18,772,248 | [['D03.633.100.759.138'], ['G05.365.590.060'], ['G02.111.570.820.486.100', 'G02.111.611.500', 'G05.360.580.100'], ['E05.196.309.742.225'], ['D03.633.100.759.590.454', 'D13.570.583.454', 'D13.570.800.453'], ['G02.282'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Functional properties of conditioned skeletal muscle: implications for muscle-powered cardiac assist. | Latissimus dorsi (LD) muscles of six canines were studied to assess changes induced by electrical conditioning and to quantify the capacity of these muscles to perform hemodynamic work. Muscles were conditioned using burst stimuli delivered over an 8-wk period. Contralateral LD were used as control. Muscles were tested... | ['Animals', 'Dogs', 'Electric Stimulation', 'Enzymes', 'Feasibility Studies', 'Glycolysis', 'Heart-Assist Devices', 'In Vitro Techniques', 'Isometric Contraction', 'Male', 'Muscle Fatigue', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Myosin Heavy Chains', 'Thorax', 'Tissue Distribution'] | 9,277,356 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.723.402'], ['D08.811'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['E04.050.430', 'E07.695.300.300', 'E07.858.082.374.300'], ['E05.481'], ['G11.427.4... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Memory training for adults with probable mild cognitive impairment: a pilot study. | Background & Objectives: This pilot study aimed to evaluate the efficacy of memory training and health training intervention over a 24-month period in people with probable mild cognitive impairment (MCI). Research Design & Methods: Based on the accepted criteria, and the neuropsychiatric measures used in the trial, MCI... | ['Aged', 'Aged, 80 and over', 'Cognitive Dysfunction', 'Ethnic Groups', 'Female', 'Health Promotion', 'Humans', 'Learning', 'Male', 'Mental Recall', 'Pilot Projects', 'Self Efficacy'] | 30,303,394 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F03.615.250.700'], ['M01.686.754', 'N01.224.317'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['F02.463.425.540.641'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Effect of D-valine and cytosine arabinoside on [3H]thymidine incorporation in rat and rabbit epididymal epithelial cell cultures. | Epithelial cell enriched primary cultures were established from the rat and the rabbit epididymis. Epithelial cell aggregates, obtained after pronase digestion of minced epididymis, attached to the culture dish and after 72 h in vitro spread out to form discrete patches of cells. These cells have an epithelioid morphol... | ['Animals', 'Cells, Cultured', 'Cytarabine', 'DNA', 'Epididymis', 'Male', 'Mitotic Index', 'Rabbits', 'Rats', 'Rats, Inbred Strains', 'Thymidine', 'Tritium', 'Valine'] | 6,698,572 | [['B01.050'], ['A11.251'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['D13.444.308'], ['A05.360.444.371'], ['E01.370.225.500.385.500', 'E05.200.500.385.500', 'E05.242.385.500'], ['B01.050.150.900.649.313.968.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B0... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Differences in clinical features of post-traumatic olfactory dysfunction and non-post-traumatic olfactory dysfunction: a follow-up study]. | Objective:To analyze the clinical features and recovery rate of post-traumatic olfactory dysfunction (PTOD) in Chinese adults in a case control follow-up study. Method:The clinical data of 202 patients who were diagnosed with olfactory dysfunction between January 2015 and December 2016 and followed up for 14 to 473 day... | ['Female', 'Follow-Up Studies', 'Humans', 'Male', 'Olfaction Disorders', 'Olfactory Pathways', 'Retrospective Studies', 'Smell'] | 29,798,185 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.751.600', 'C23.888.592.763.550'], ['A08.186.211.180.699', 'A08.612.220.640'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Optically functional isoxanthopterin crystals in the mirrored eyes of decapod crustaceans. | The eyes of some aquatic animals form images through reflective optics. Shrimp, lobsters, crayfish, and prawns possess reflecting superposition compound eyes, composed of thousands of square-faceted eye units (ommatidia). Mirrors in the upper part of the eye (the distal mirror) reflect light collected from many ommatid... | ['Animals', 'Crystallography, X-Ray', 'Decapoda', 'Nanoparticles', 'Photoreceptor Cells', 'Retina', 'Xanthopterin'] | 29,463,710 | [['B01.050'], ['E05.196.309.742.225'], ['B01.050.500.131.365.190'], ['J01.637.512.600'], ['A08.675.650.850.625', 'A08.675.650.915.937', 'A08.800.950.937', 'A09.371.729.831.625', 'A11.671.650.850.625', 'A11.671.650.915.937'], ['A09.371.729'], ['D03.633.100.733.631.825', 'D23.767.831.742']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Parnaparin versus aspirin in the treatment of retinal vein occlusion. A randomized, double blind, controlled study. | INTRODUCTION: Retinal vein occlusion (RVO) is a common cause of unilateral visual loss. Evidence based treatment recommendations for patients with RVO cannot be made because of the lack of adequate clinical trials. To compare the efficacy and safety of aspirin and of a low molecular weight heparin, parnaparin, in the t... | ['Aspirin', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Administration Schedule', 'Female', 'Fibrinolytic Agents', 'Hemorrhage', 'Heparin, Low-Molecular-Weight', 'Humans', 'Male', 'Middle Aged', 'Platelet Aggregation Inhibitors', 'Platelet Function Tests', 'Retinal Vein Occlusion', 'Treatment Outco... | 19,477,488 | [['D02.455.426.559.389.657.410.595.176'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['C23.550.414'], ['D09.698.373.400.300'], ['B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Adrenal medulla as a mediator of diet-induced hypertension. | Male Sprague-Dawley rats fed either a high-fat or glucose-enriched diet for 10 wk developed higher blood pressure (BP) and higher urinary catecholamine excretion than rats fed a control diet. After 10 wk of diet treatment, systolic BP was 164 +/- 3, 156 +/- 2, and 145 +/- 4 mmHg in rats fed the high-fat, glucose, and c... | ['Adrenal Medulla', 'Adrenalectomy', 'Animals', 'Body Weight', 'Catecholamines', 'Diet', 'Energy Intake', 'Hypertension', 'Male', 'Rats', 'Rats, Sprague-Dawley'] | 8,342,672 | [['A06.300.071.265'], ['E04.270.115'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['G07.203.650.240'], ['G07.203.650.240.340'], ['C14.907.489'], ['B01.050.150.900.649.313.992.635.50... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chronic effects of the novel glucocorticosteroid RPR 106541 administered to beagle dogs by inhalation. | The preclinical safety of RPR 106541, a novel 17-thiosteroid, was evaluated in young adult and mature dogs by inhalation exposure for 26 weeks and 52 weeks, respectively. A dry powder formulation of RPR 106541 in lactose was administered to young adult dogs (approximately 6 months of age at initiation) at doses of 0 (a... | ['Administration, Inhalation', 'Adrenal Glands', 'Aerosols', 'Androstenes', 'Animals', 'Anti-Asthmatic Agents', 'Body Weight', 'Bone Marrow', 'Clinical Chemistry Tests', 'Dogs', 'Female', 'Femur', 'Gonads', 'Liver', 'Lymphoid Tissue', 'Male', 'Mammary Glands, Animal', 'Nebulizers and Vaporizers', 'Organ Size', 'Powders... | 10,805,140 | [['E02.319.267.050'], ['A06.300.071'], ['D20.280.055', 'D26.255.165.055'], ['D04.210.500.054.079'], ['B01.050'], ['D27.505.954.796.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['A15.382.216'], ['E01.370.225.124', 'E05.200.124'], ['B01.050.15... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Patient views on choice and participation in primary health care. | Within modern health care, much attention is given to the tasks of identifying patient preferences and then delivering health care services accordingly. Standardised solutions are not always acceptable to patients with divergent needs and preferences, and the growing number of treatment alternatives makes patient parti... | ['Adolescent', 'Adult', 'Aged', 'Choice Behavior', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Participation', 'Primary Health Care', 'State Medicine', 'Sweden'] | 11,163,651 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F02.463.785.373.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.500.620', 'F01.145.488.887.500.620', 'N02.421.143.212.300', 'N03.540.245.360.300', 'N05.300.150.800.500.620'], ['N04.590.233.727'], ['N03.349.550.902',... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Prostatic abscess evaluated by serial computed tomography. | Prostatic abscess appears on computed tomography (CT) as multiple, well-demarcated fluid collections within the prostate gland and/or periprostatic tissues. Since prostatic abscess may not be differentiated from other prostatic disease on the basis of history and physical examination alone, CT can contribute significan... | ['Abscess', 'Aged', 'Humans', 'Male', 'Prostatic Diseases', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 3,885,540 | [['C01.830.025', 'C23.550.470.756.100'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.565'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['E01.370.350.850']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diastereo- and enantioselective synthesis of orthogonally protected 2,4-diaminocyclopentanecarboxylates: a flip from beta-amino- to beta,gamma-diaminocarboxylates. | Conformationally restricted, orthogonally protected 2,4-diaminocarboxylates with a cyclopentane skeleton were efficiently synthesized from beta-lactam 6, the syntheses involving strategies of diastereoselective epoxidation of the beta-lactam and the corresponding monoprotected amino esters with opposite selectivities f... | ['Carboxylic Acids', 'Cyclopentanes', 'Esters', 'Ethylene Oxide', 'Molecular Conformation', 'Sodium Azide', 'Stereoisomerism', 'beta-Lactams'] | 17,935,349 | [['D02.241'], ['D02.455.426.392.368.450'], ['D02.241.400'], ['D02.355.291.411.417'], ['G02.111.570.820'], ['D01.625.100.750', 'D01.857.462'], ['G02.607.445.682'], ['D02.065.589.099', 'D02.886.108', 'D03.633.100.300']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A systematic review of work accommodations for people with mental disorders. | BACKGROUND: Work accommodations are adjustments made in the work place or to policies surrounding employment to accommodate an individual with a mental disorder to be successful in completing work related tasks.OBJECTIVE: The purpose of this systematic review is to identify work accommodations that are available and th... | ['Cost-Benefit Analysis', 'Employment, Supported', 'Humans', 'Mental Disorders', 'Mentally Ill Persons', 'Workplace'] | 31,658,080 | [['N03.219.151.125'], ['N01.824.245.350', 'N02.421.784.644.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.150.725'], ['N01.824.245.925', 'N04.452.677.975']] | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gravity and hemineglect. | Spatial cognition requires the integration of visual inputs with proprioceptive and vestibular information about the position of the eye, the head and the body. All these sources are used by the brain to produce multiple higher-order (e.g. egocentric) representations of space, subserving accurate spatial behaviour. Suc... | ['Aged', 'Attention', 'Brain Damage, Chronic', 'Cerebrovascular Disorders', 'Functional Laterality', 'Gravitation', 'Humans', 'Orientation', 'Posture', 'Psychomotor Performance', 'Space Perception', 'Vestibular Nuclei'] | 8,742,490 | [['M01.060.116.100'], ['F02.830.104.214'], ['C10.228.140.140'], ['C10.228.140.300', 'C14.907.253'], ['F02.830.297.425', 'G11.561.225.425'], ['G01.060.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.058.577', 'F02.830.606'], ['G11.427.695'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['F02.463.593.778'], [... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fluorocarbon nanodrops as acoustic temperature probes. | This work investigated the use of superheated fluorocarbon nanodrops for ultrasound thermal imaging and the use of mixed fluorocarbons for tuning thermal and acoustic thresholds for vaporization. Droplets were fabricated by condensing phospholipid-coated microbubbles containing C3F8 and C4F10 mixed at various molar rat... | ['Acoustics', 'Fluorocarbons', 'Models, Chemical', 'Nanostructures', 'Temperature'] | 26,359,919 | [['H01.671.031'], ['D02.455.526.510.435'], ['E05.599.495'], ['J01.637.512'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Comparing the German versions of the Strengths and Difficulties Questionnaire (SDQ-Deu) and the Child Behavior Checklist. | The Strengths and Difficulties Questionnaire (SDQ) is a brief behavioural screening questionnaire that can be completed in about 5 minutes by the parents and teachers of 4-16 year olds. The scores of the English version correlate well with those of the considerably longer Child Behavior Checklist (CBCL). The present st... | ['Adolescent', 'Attention Deficit Disorder with Hyperactivity', 'Child', 'Child Behavior Disorders', 'Child, Preschool', 'Female', 'Germany', 'Humans', 'Language', 'Male', 'Psychometrics', 'Surveys and Questionnaires'] | 11,202,102 | [['M01.060.057'], ['F03.625.094.150'], ['M01.060.406'], ['F03.625.141'], ['M01.060.406.448'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F04.711.780'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Hotspotting: Development of an Interprofessional Education and Service Learning Program for Care Management in Home Care Patients. | The purpose of this article is to describe a service learning opportunity where interprofessional teams of students worked together to address patients' social determinants of health through home visits. This article describes this process, known as "hotspotting," and presents the development of this project, including... | ['Education, Nursing', 'Home Care Services', 'House Calls', 'Humans', 'Interprofessional Relations', 'Nursing Education Research', 'Patient Care Management', 'Program Development', 'Social Determinants of Health', 'Students, Health Occupations', 'Students, Nursing', 'Students, Pharmacy'] | 29,595,568 | [['I02.358.462'], ['N02.421.143.524', 'N02.421.539.089'], ['N04.452.758.307'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['H01.770.644.145.390.413', 'H02.478.395.413', 'I02.358.462.612', 'N04.590.233.508.613.413'], ['N04.590'], ['N04.452.760'], ['N01.224.425.762', 'N01.400.675'], ['M01.848.7... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Analysis of the antipyretic action of alpha-melanocyte-stimulating hormone in rabbits. | alpha-Melanocyte-stimulating hormone (alpha-MSH) or paracetamol was injected into a lateral cerebral ventricle (I.C.V.) of rabbits with elevations in rectal temperature induced by sodium arachidonate (I.C.V.), prostaglandin E2 (I.C.V.) or leucocytic pyrogen (I.V.). alpha-MSH (200 ng) was more effective than paracetamol... | ['Acetaminophen', 'Animals', 'Arachidonic Acids', 'Body Temperature', 'Cerebral Ventricles', 'Cold Temperature', 'Dinoprostone', 'Interleukin-1', 'Male', 'Melanocyte-Stimulating Hormones', 'Prostaglandins E', 'Proteins', 'Pyrogens', 'Rabbits', 'Time Factors'] | 3,858,506 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['B01.050'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['E01.370.600.875.374', 'G07.110'], ['A08.186.211.140'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['D10.251.35... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Crystal structure of the apo form of a â-transaminase from Mesorhizobium sp. strain LUK. | Pyridoxal 5'-phosphate (PLP)-dependent â-transaminases (âTAs) reversibly catalyze transamination reactions by recognizing amino groups linked to the â-carbon atoms of their substrates. Although several âTA structures have been determined as holo forms containing PLP, little is known about the effect of PLP on the conve... | ['Bacterial Proteins', 'Catalytic Domain', 'Crystallography, X-Ray', 'Mesorhizobium', 'Models, Molecular', 'Protein Binding', 'Protein Domains', 'Protein Structure, Secondary', 'Transaminases'] | 30,805,955 | [['D12.776.097'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['E05.196.309.742.225'], ['B03.660.050.600.500'], ['E05.599.595'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.275.750', 'G02.111.570.820.709.610.500'], ['G02.111.570.820.709.600'], ['D08.811.913.477.700']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanical thrombectomy in acute embolic stroke: preliminary results with the revive device. | BACKGROUND AND PURPOSE: The purpose of this study was to evaluate the safety and technical feasibility of a new thrombectomy device (Revive; Micrus Endovascular) in the endovascular treatment of acute ischemic stroke.METHODS: Ten patients with acute large vessel occlusions were treated with the Revive device between Oc... | ['Aged', 'Aged, 80 and over', 'Brain Ischemia', 'Female', 'Humans', 'Intracranial Embolism', 'Intracranial Thrombosis', 'Male', 'Prospective Studies', 'Stroke', 'Thrombectomy', 'Treatment Outcome'] | 21,817,139 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.300.150', 'C14.907.253.092'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.525.400', 'C14.907.253.566.300', 'C14.907.355.590.213.300'], ['C10.228.140.300.525.425', 'C14.907.253.566.350', 'C14.907.355.590.213.350'], ['E05.318.372.500.750.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pharmacological properties and toxicology of MED-15, a prodrug of tolmetin. | In this study the pharmacological evaluation of MED-15, a non-acidic prodrug of tolmetin, is described. After oral administration the new compound shows a marked anti-inflammatory activity similar to that of tolmetin, but with minor ulcerogenic action and lower acute toxicity. | ['Administration, Oral', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Female', 'Glycine', 'Lethal Dose 50', 'Male', 'Peptic Ulcer', 'Prodrugs', 'Pyrroles', 'Rats', 'Rats, Wistar', 'Tolmetin'] | 1,308,474 | [['E02.319.267.100'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D12.125.481'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['C06.405.469.275.800', 'C06.405.748.586'], ['D26.675'], ['D03.383.129.578'], ['B01.050.150.900.649.313.992... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel treatment for patients with hereditary haemorrhagic telangiectasia. | Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by dermal, mucosal, and visceral telangiectases as well as pulmonary and cerebral arteriovenous malformations. Recurrent epistaxis occurs in the majority of patients, and by the very nature of the thin walled vessels involved i... | ['Aged', 'Aged, 80 and over', 'Epistaxis', 'Female', 'Fibrin Tissue Adhesive', 'Humans', 'Telangiectasia, Hereditary Hemorrhagic', 'Tissue Adhesives'] | 12,437,844 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C08.460.261', 'C09.603.261', 'C23.550.414.712', 'C23.888.852.040'], ['D12.776.124.270.305'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.454.900', 'C14.907.823.780', 'C15.378.463.515.900', 'C16.131.240.850.968'], ['D25.919', 'D27.720.102.919', 'E07.858.690... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Phylogenetic assignment of Mycobacterium tuberculosis Beijing clinical isolates in Japan by maximum a posteriori estimation. | Intra-species phylogeny of Mycobacterium tuberculosis has been regarded as a clue to estimate its potential risk to develop drug-resistance and various epidemiological tendencies. Genotypic characterization of variable number of tandem repeats (VNTR), a standard tool to ascertain transmission routes, has been improving... | ['Algorithms', 'Bacterial Typing Techniques', 'Beijing', 'DNA, Bacterial', 'Genotype', 'Humans', 'Japan', 'Minisatellite Repeats', 'Models, Genetic', 'Multilocus Sequence Typing', 'Mycobacterium tuberculosis', 'Phylogeny', 'Phylogeography', 'Tuberculosis'] | 26,220,897 | [['G17.035', 'L01.224.050'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['Z01.252.474.164.225', 'Z01.433.114'], ['D13.444.308.212'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['G02.111.570.080.708.800.550', 'G05.360.080.708.800.550', 'G05.360.340.024.850.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
Effects of WR1065 on 6-hydroxydopamine-induced motor imbalance: Possible involvement of oxidative stress and inflammatory cytokines. | Over production of reactive oxygen species (ROS) is postulated to be the main contributor in degeneration of nigrostriatal dopaminergic neurons. In this study we investigated the effects of WR1065, a free radical scavenger, on motor imbalance, oxidative stress parameters and inflammatory cytokines in CSF and brain of h... | ['Animals', 'Disease Models, Animal', 'Glutathione', 'Inflammation', 'Interleukin-1beta', 'Lipid Peroxidation', 'Male', 'Malondialdehyde', 'Mercaptoethylamines', 'Motor Activity', 'Neuroprotective Agents', 'Oxidative Stress', 'Oxidopamine', 'Parkinsonian Disorders', 'Pars Compacta', 'Rats', 'Rats, Wistar', 'Tumor Necro... | 27,222,379 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.644.456.448'], ['C23.550.470'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.600', 'D12.776.467.374.465.010.600', 'D12.776.467.374.500.400.600', 'D23.529.374.465.131.600', 'D23.529.374.500.400.600'], ['G02.111.515', 'G03.295.531.587'], ['D02... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Behavioral characterization of dopamine D5 receptor null mutant mice. | To study behavioral functions of the D5 subtype, mice were generated with null mutations in the D5 gene. This 1st behavioral characterization of D5 null mutant mice (D5-/-) indicated normal general health, sensory abilities, and neurological reflexes. Under basal conditions, D5-/- mice were generally normal on locomoto... | ['Animals', 'Arousal', 'Behavior, Animal', 'Brain', 'Exploratory Behavior', 'Female', 'Locomotion', 'Male', 'Maze Learning', 'Mice', 'Mice, Knockout', 'Mice, Neurologic Mutants', 'Motivation', 'Neural Inhibition', 'Receptors, Dopamine D1', 'Receptors, Dopamine D5', 'Reflex, Startle'] | 11,584,926 | [['B01.050'], ['F02.830.104', 'G11.561.035'], ['F01.145.113'], ['A08.186.211'], ['F01.145.387', 'F01.658.370'], ['G07.568.500', 'G11.427.410.568'], ['F02.463.425.874.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B01.050.150.900.649.31... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Needle perforation of the bowel in childhood. | Accidental ingestion of foreign bodies occurs frequently in childhood. The majority of them are passed spontaneously, and conservative management generally is recommended for foreign bodies in the stomach and duodenum. However, in some cases, operative intervention should be considered to prevent undesirable complicati... | ['Abdomen, Acute', 'Appendicitis', 'Cecal Diseases', 'Child, Preschool', 'Dental Instruments', 'Diagnosis, Differential', 'Female', 'Foreign-Body Migration', 'Humans', 'Intestinal Perforation', 'Jejunal Diseases', 'Male'] | 14,966,749 | [['C23.888.592.612.054.200', 'C23.888.821.030.249'], ['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['C06.405.469.110'], ['M01.060.406.448'], ['E06.186.501', 'E07.222.501'], ['E01.171'], ['C26.392.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.557'], ['C06.405.469.600']] | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Caries management in the dental practice. | Practical, cost-effective implementation of caries management in general practice has been limited by several factors. The single pathogen model of disease has not been effective in clinical caries management, and the advent of the ecologic plaque model and a better understanding of the management of imbalances in dent... | ['Adult', 'Biofilms', 'Child', 'Dental Caries', 'Dental Caries Activity Tests', 'Dental Caries Susceptibility', 'Dental Plaque', 'General Practice, Dental', 'Health Education, Dental', 'Health Plan Implementation', 'Humans', 'Hydrogen-Ion Concentration', 'Insurance Claim Reporting', 'Lactobacillus', 'Practice Managemen... | 19,301,525 | [['M01.060.116'], ['A20.593', 'G06.120'], ['M01.060.406'], ['C07.793.720.210'], ['E06.342.250'], ['G10.549.140'], ['C07.793.208.377'], ['H02.163.342'], ['I02.233.332.374', 'N02.421.726.407.457', 'N06.890.410'], ['N03.349.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['N03.219.521.576.210'], ['B03... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Rubella and congenital rubella syndrome--United States, 1994-1997. | Indigenous rubella and congenital rubella syndrome (CRS) have been targeted for elimination in the United States by the year 2000. Progress toward reaching this goal is monitored through the National Notifiable Diseases Surveillance System and the National Congenital Rubella Syndrome Registry. From 1969 through 1989, t... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Disease Outbreaks', 'Female', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Male', 'Rubella', 'Rubella Syndrome, Congenital', 'United States'] | 9,148,137 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['N06.850.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.703'], ['M01.060.703.520'], ['C01.925.782.930.700.700'], ... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An Integrated Approach to Bias in a Longitudinal Survey in the United Kingdom: Assessing Construct, Method, and Item Bias in the General Health Questionnaire (GHQ-12). | Construct, method, and item bias are three levels of measurement bias (i.e., internal bias) essential for valid group comparisons. While many studies often focus on only one level of bias, an integrated perspective on bias is still missing, especially in longitudinal designs. The aim of this study is to address bias in... | ['Adolescent', 'Adult', 'Aged', 'Bias', 'Cultural Characteristics', 'Emigrants and Immigrants', 'Female', 'Health Surveys', 'Humans', 'Longitudinal Studies', 'Male', 'Mental Health', 'Middle Aged', 'Surveys and Questionnaires', 'United Kingdom', 'Young Adult'] | 29,117,704 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['N05.715.350.150', 'N06.850.490.500'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['M01.189'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.71... | ['Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Outcomes of standard and tailored anti-tuberculosis regimens in patients with tuberculous pleural effusion. | BACKGROUND: In an era of increasing concerns about drug resistance, there are limited data on treatment outcomes and recurrence rates after standard short-course anti-tuberculosis treatment in patients with culture-negative tuberculous pleural effusion (TPE).OBJECTIVE: To compare treatment outcomes and recurrence rates... | ['Adult', 'Aged', 'Antitubercular Agents', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Mycobacterium tuberculosis', 'Pleural Effusion', 'Prevalence', 'Recurrence', 'Republic of Korea', 'Retrospective Studies', 'Treatment Outcome', 'Tuberculosis, Multidrug-Resistant'] | 27,776,594 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085.255'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['C08.528.652'], ['E05.318.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Nocturnal panic and recent life events. | Recent research has hypothesized an association between traumatic events and nocturnal panic (NP). The purpose of this study was to investigate whether the onset of nocturnal panic attacks is associated with a higher frequency of and/or greater severity of stressful or traumatic life events than that of patients with p... | ['Adult', 'Age of Onset', 'Female', 'Humans', 'Italy', 'Life Change Events', 'Male', 'Observer Variation', 'Panic Disorder', 'Sleep'] | 16,175,567 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['F01.829.458.410'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['F03.080.700'], ['F02.830.855', 'G11.561.803']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
HLA-dependent hypersensitivity reaction to nevirapine in Chinese Han HIV-infected patients. | In this study, one hundred and three HIV-positive Chinese Han patients treated with a nevirapine (NVP)-based regimens were investigated for the association between nevirapine hypersensitivity reaction (NVP HSR) and human leukocyte antigen (HLA) allele. HLA-Cw, -DRB1 alleles were determined in 32 NVP HSR cases and 71 NV... | ['Acquired Immunodeficiency Syndrome', 'Adult', 'Alleles', 'Anti-HIV Agents', 'Asian Continental Ancestry Group', 'CD4 Lymphocyte Count', 'Drug Hypersensitivity', 'Female', 'Genetic Predisposition to Disease', 'HLA-C Antigens', 'HLA-DRB1 Chains', 'Humans', 'Male', 'Nevirapine', 'Prevalence', 'Risk Factors'] | 21,902,584 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['G05.360.340.024.340.030'], ['D27.505.954.122.388.077.088'], ['M01.686.508.200'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comprehensive qPCR profiling of gene expression in single neuronal cells. | A major challenge in neuronal stem cell biology lies in characterization of lineage-specific reprogrammed human neuronal cells, a process that necessitates the use of an assay sensitive to the single-cell level. Single-cell gene profiling can provide definitive evidence regarding the conversion of one cell type into an... | ['Cell Differentiation', 'Cells, Cultured', 'Gene Expression Profiling', 'Humans', 'Microfluidics', 'Neurons', 'Polymerase Chain Reaction', 'RNA, Messenger', 'Single-Cell Analysis'] | 22,193,304 | [['G04.152'], ['A11.251'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['A08.675', 'A11.671'], ['E05.393.620.500'], ['D13.444.735.544'], ['E05.242.900']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Deviation in cortisol metabolism induced by rifampicin. Therapeutic consequences in adrenal failure (author's transl)]. | Deviation of cortisol metabolism in favour of its 6 beta-hydroxylated derivative was demonstrated in two patients with adrenal failure receiving substitution corticosteroid therapy and rifampicin. The existence of a frank increase in the metabolic clearance antipyrin was in favour of an hepatic enzyme induction. After ... | ['Addison Disease', 'Adrenal Cortex Hormones', 'Adrenal Insufficiency', 'Adult', 'Aged', 'Antipyrine', 'Enzyme Induction', 'Humans', 'Hydrocortisone', 'Hydroxycorticosteroids', 'Liver', 'Male', 'Metabolic Clearance Rate', 'Rifampin', 'Steroid Hydroxylases', 'Tuberculosis'] | 471,734 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cambrian lobopodians and extant onychophorans provide new insights into early cephalization in Panarthropoda. | Cambrian lobopodians are important for understanding the evolution of arthropods, but despite their soft-bodied preservation, the organization of the cephalic region remains obscure. Here we describe new material of the early Cambrian lobopodian Onychodictyon ferox from southern China, which reveals hitherto unknown he... | ['Animals', 'Arthropods', 'Biological Evolution', 'China', 'Extremities', 'Fossils', 'Head', 'Mouth'] | 23,232,391 | [['B01.050'], ['B01.050.500.131'], ['G05.045', 'G16.075'], ['Z01.252.474.164'], ['A01.378'], ['I01.076.368.584.311'], ['A01.456'], ['A01.456.505.631', 'A03.556.500', 'A14.549']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Undetected tuberculosis in prison. Source of infection for community at large. | Discovery of two cases of infectious tuberculosis in a state prison in 1976 prompted a careful study of the entire population of 1,500. Eight more cases were found, giving a morbidity of 670/100,000 (arkansas rate, 21.1). The epidemic was aborted by the use of isoniazid and the establishment of a program for screening ... | ['Arkansas', 'Humans', 'Isoniazid', 'Prisoners', 'Quality of Health Care', 'Tuberculosis, Pulmonary', 'United States'] | 712,956 | [['Z01.107.567.875.750.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['M01.729'], ['N04.761', 'N05.715'], ['C01.150.252.410.040.552.846.899', 'C01.748.939', 'C08.381.922', 'C08.730.939'], ['Z01.107.567.875']] | ['Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Signaling pathways of bisphenol A-induced apoptosis in hippocampal neuronal cells: role of calcium-induced reactive oxygen species, mitogen-activated protein kinases, and nuclear factor-kappaB. | In the present study, we investigated the neurotoxicity of bisphenol A [BPA; 2,2-bis-(4 hydroxyphenyl) propane] and the underlying mechanisms of action in mouse hippocampal HT-22 cells. BPA, known to be a xenoestrogen, is used in the production of water bottles, cans, and teeth suture materials. BPA-treated HT-22 cells... | ['Animals', 'Apoptosis', 'Benzhydryl Compounds', 'Blotting, Western', 'Calcium', 'Cell Line', 'Electrophoretic Mobility Shift Assay', 'Enzyme Activation', 'Flow Cytometry', 'Hippocampus', 'Mice', 'Mitogen-Activated Protein Kinases', 'NF-kappa B', 'Neurons', 'Neurotoxins', 'Phenols', 'Reactive Oxygen Species', 'Signal T... | 18,521,933 | [['B01.050'], ['G04.146.954.035'], ['D02.455.426.559.389.115'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251.210'], ['E05.196.401.500'], ['G02.111.263', 'G03.328'], ['E01.370.225.500.363.342', 'E01.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of the second-order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products. | Paracetamol is a widely used nonsalicylate analgesic and antipyretic drug. The existing methods for the determination of paracetamol in biological fluids are mainly HPLC techniques, although there are some reported methods based on spectrophotometric determinations. However, all these methods involve some extraction or... | ['Acetaminophen', 'Biopharmaceutics', 'Humans', 'Spectrophotometry, Ultraviolet', 'Technology, Pharmaceutical'] | 14,520,684 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['H01.158.703.003', 'H02.628.049'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['E05.916', 'J01.897.836']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Soluble form of LR11 is highly increased in the vitreous fluids of patients with idiopathic epiretinal membrane. | PURPOSE: LR11 (also called SorLA or SORL1) is a migration regulator of adherent cells with the immature proliferative phenotype. The present study investigated the clinical and pathological involvement of the soluble form of LR11 (sLR11) in the idiopathic epiretinal membrane (iERM).METHODS: The subjects were 51 patient... | ['Aged', 'Biomarkers', 'Cell Movement', 'Enzyme-Linked Immunosorbent Assay', 'Epiretinal Membrane', 'Female', 'Humans', 'LDL-Receptor Related Proteins', 'Male', 'Membrane Transport Proteins', 'Nerve Tissue Proteins', 'Retrospective Studies', 'Transforming Growth Factor beta2', 'Vitreous Body'] | 28,102,455 | [['M01.060.116.100'], ['D23.101'], ['G04.198', 'G07.568.500.180'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['C11.768.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.526', 'D12.776.543.750.710.450.500'], ['D12.776.157.530', 'D... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Experimental carcinoma of the biliary tract induced in dogs by N-ethyl-N'-nitro-N-nitrosoguanidine. | The present study was designed to produce the experimental carcinoma of the biliary tract in dogs. Tube cholecystostomy was constructed in 8 mongrel dogs and 5-10 ml of 0.7-1.0 mg/ml solution of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered through the tube every day for the maximum period of 180 days. As... | ['Adenocarcinoma', 'Animals', 'Bile Duct Neoplasms', 'Common Bile Duct', 'Dogs', 'Female', 'Male', 'Methylnitronitrosoguanidine', 'Neoplasms, Experimental', 'Nitrosoguanidines'] | 892,336 | [['C04.557.470.200.025'], ['B01.050'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['A03.159.183.079.300'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.078.370.649.400', 'D02.654.567.400'], ['C04.619', 'E05.598.500.496'], ['D02.078.370.649', 'D02.654.567']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Colonic volvulus]. | A study of 62 cases of acute volvulus of the colon occurring in 45 patients is reported. A plan of management is discussed. Thanks to early diagnosis and treatment the mortality rate was improved and compares favourably with data in the literature. | ['Adult', 'Aged', 'Barium Sulfate', 'Colonic Diseases', 'Enema', 'Female', 'Humans', 'Intestinal Obstruction', 'Intestinal Perforation', 'Male', 'Middle Aged', 'Peritonitis', 'Pulmonary Embolism', 'Sigmoidoscopy'] | 7,302,546 | [['M01.060.116'], ['M01.060.116.100'], ['D01.103.075', 'D01.875.800.800.850.075'], ['C06.405.469.158'], ['E02.319.347'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531'], ['C06.405.469.557'], ['M01.060.116.630'], ['C01.463.600', 'C06.844.640'], ['C08.381.746', 'C14.907.355.350.700'], ['E01.370.372.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Progesterone increases the incidence of bovine herpesvirus 1 reactivation from latency and stimulates productive infection. | Bovine herpesvirus 1 (BoHV-1), including modified live vaccines, can cause abortions in pregnant cows. Progesterone maintains pregnancy and promotes spermiogenesis and testosterone biosynthesis in males: furthermore, progesterone is a neuro-steroid. Recent published studies demonstrated progesterone stimulated the BoHV... | ['Animals', 'Antibodies, Viral', 'Cattle', 'Cattle Diseases', 'Female', 'Herpesviridae Infections', 'Herpesvirus 1, Bovine', 'Male', 'Progesterone', 'Rabbits', 'Sex Factors', 'Virus Activation', 'Virus Latency', 'Virus Replication', 'Virus Shedding'] | 31,697,987 | [['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['C01.925.256.466'], ['B04.280.382.100.900.400'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334.851.687.750'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Few infected CD4+ T cells but a high proportion of replication-competent provirus copies in asymptomatic human immunodeficiency virus type 1 infection. | The virus load in CD4+ T cells from six asymptomatic human immunodeficiency virus type 1 (HIV-1)-infected individuals was determined by limiting-dilution analysis with a sensitive virus isolation procedure and the polymerase chain reaction (PCR). Both methods allowed detection of one HIV-1-infected cell among 10(5) uni... | ['Acquired Immunodeficiency Syndrome', 'CD4-Positive T-Lymphocytes', 'DNA, Viral', 'HIV-1', 'Humans', 'Leukocyte Count', 'Polymerase Chain Reaction', 'Proviruses', 'Sensitivity and Specificity', 'Virus Replication'] | 1,672,165 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['D13.444.308.568'], ['B04.820.650.589.650.350.400'],... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Brucellosis in a student]. | We describe the case of a student with a history of two and a half months of fever, hepatosplenomegaly, cutaneous, hematological and bone manifestations, within an epidemiological background compatible with the diagnosis of Brucellosis. Diagnosis of Brucella abortus was confirmed by serology and positive blood cultures... | ['Anti-Bacterial Agents', 'Brucella abortus', 'Brucellosis', 'Child', 'Doxycycline', 'Follow-Up Studies', 'Humans', 'Male', 'Rifampin'] | 17,186,084 | [['D27.505.954.122.085'], ['B03.440.400.425.215.500.100', 'B03.660.050.070.100.100'], ['C01.150.252.400.167'], ['M01.060.406'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Attenuation of platelet reactivity by enoxaparin compared with unfractionated heparin in patients undergoing haemodialysis. | BACKGROUND: Increased platelet reactivity presages adverse cardiac events. Because both haemodialysis and unfractionated heparin (UFH) can increase platelet reactivity, we compared platelet reactivity during haemodialysis when patients were anticoagulated with UFH or enoxaparin.METHODS: Patients (n = 20) underwent cons... | ['Aged', 'Anticoagulants', 'Blood Platelets', 'Enoxaparin', 'Female', 'Fibrinogen', 'Flow Cytometry', 'Heparin', 'Humans', 'Male', 'Middle Aged', 'P-Selectin', 'Platelet Activation', 'Protein Binding', 'Renal Dialysis'] | 15,034,156 | [['M01.060.116.100'], ['D27.505.954.502.119'], ['A11.118.188', 'A15.145.229.188'], ['D09.698.373.400.300.200'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Incidence, risk factors, and mortality of neonatal and late-onset dilated cardiomyopathy associated with cardiac neonatal lupus. | BACKGROUND: Dilated cardiomyopathy (DCM), a well-known complication of cardiac neonatal lupus, is associated with high mortality rate. Its risk factors remain unclear.METHODS: We analyzed occurrence of postnatal DCM among children with high-degree congenital heart block (CHB) and mothers with anti-SSA and/or anti-SSB a... | ['Adolescent', 'Adult', 'Age of Onset', 'Cardiomyopathy, Dilated', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Lupus Erythematosus, Systemic', 'Male', 'Mortality', 'Registries', 'Retrospective Studies', 'Risk Factors', 'Young Adult'] | 28,843,719 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['C14.280.195.160', 'C14.280.238.070', 'C16.320.488.750'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long-term outcome of chevron-osteotomy in juvenile hallux valgus. | The long-term outcome of juvenile hallux valgus treated by a modified Austin procedure was investigated. The clinical (subjective, AOFA Scores) and radiological outcome (hallux valgus angles, intermetatarsal angles, position of the sesamoid bones and metatarsal index of 15 feet in 12 patients, aged 14 years and 2 month... | ['Adolescent', 'Child', 'Hallux Valgus', 'Humans', 'Osteotomy', 'Radiography', 'Retrospective Studies', 'Treatment Outcome'] | 24,350,518 | [['M01.060.057'], ['M01.060.406'], ['C05.330.610'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.555.580'], ['E01.370.350.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], [... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Symptomatic and asymptomatic amoebiasis in two heterosexual couples. | Four cases of amoebiasis are described: two symptomatic with intestinal and hepatic involvement and two asymptomatic, diagnosed in two, heterosexual, Italian couples. Infection was probably acquired first by the men, via an indirect faccal-oral route, and then transmitted to their partners in the same way. The two amoe... | ['Acetamides', 'Adult', 'Amebicides', 'Animals', 'Disease Transmission, Infectious', 'Drug Therapy, Combination', 'Entamoeba histolytica', 'Entamoebiasis', 'Feces', 'Female', 'Heterosexuality', 'Humans', 'Italy', 'Male', 'Ornidazole', 'Paromomycin', 'Spouses'] | 10,715,677 | [['D02.065.064', 'D02.241.081.018.110'], ['M01.060.116'], ['D27.505.954.122.250.100.055'], ['B01.050'], ['N06.850.335'], ['E02.319.310'], ['B01.046.500.100.700.335.330'], ['C01.610.752.049.407'], ['A12.459'], ['F01.145.802.975.400', 'G08.686.867.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], [... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social ... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Ventriculoperitoneal Shunting in Alobar Holoprosencephaly: Does it Work Even When Patient Has No Sign of Raised Intracranial Pressure? | Holoprosencephaly (HPE) is a developmental anomaly of forebrain characterized by a failure of division of the embryonic forebrain into hemispheres. It is associated with a set of facial anomalies at a rate of 80%. Survival rate, particularly in alobar HPE, is quite low. Alobar HPE is usually associated with a large dor... | ['Female', 'Holoprosencephaly', 'Humans', 'Hydrocephalus', 'Infant, Newborn', 'Infant, Premature', 'Intracranial Hypertension', 'Intracranial Pressure', 'Survival Rate', 'Ventriculoperitoneal Shunt'] | 30,896,515 | [['C05.660.207.410', 'C10.500.034.875', 'C16.131.077.410', 'C16.131.260.380', 'C16.131.621.207.410', 'C16.131.666.034.875', 'C16.320.180.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.602'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['C10.228.140.631'], ['G11.561.170.505'], ['E05.318.308.985.... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
RNA polymerase II depletion promotes transcription of alternative mRNA species. | BACKGROUND: Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induction of genes that assist the cells in tolerating the stress and facilitate the repair of the cellul... | ['Alternative Splicing', 'Gene Deletion', 'Polyadenylation', 'RNA Polymerase II', 'RNA, Messenger', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Transcription, Genetic'] | 27,578,267 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G02.111.760.225.710', 'G03.839.225.710', 'G05.308.700.225.710'], ['D08.811.913.696.445.735.270.762'], ['D13.444.735.544'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750'], ['G02.111.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis. | BACKGROUND: NSAIDs are accepted as the most predictably efficacious medical treatment of the clinical signs of osteoarthritis (OA). The marine-based fatty-acid compound PCSO-524 has been proposed as an adjunctive treatment for canine OA, however benefits of this agent is still controversial. The purpose of this study w... | ['4-Butyrolactone', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Dinoprostone', 'Dog Diseases', 'Dogs', 'Double-Blind Method', 'Drug Therapy, Combination', 'Fatty Acids, Unsaturated', 'Female', 'Gait', 'Male', 'Osteoarthritis', 'Pain', 'Pain Measurement', 'Prospective Studies', 'Sulfones'] | 31,623,621 | [['D02.540.150', 'D03.383.312.150'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Estimating dose equivalence for new routes of drug administration. | For patient's convenience, dose administration of insulin via oral inhalation is often considered as an alternative to subcutaneous administration. An important statistical problem is to estimate dose equivalence, which is the amount of drug needed to be delivered by inhalation to generate an equivalent pharmacokinetic... | ['Administration, Inhalation', 'Adolescent', 'Adult', 'Algorithms', 'Area Under Curve', 'Computer Simulation', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Hypoglycemic Agents', 'Injections, Subcutaneous', 'Insulin', 'Male', 'Middle Aged', 'Models, Statistical', 'Pharmaceutical Preparations', 'Sample Size'] | 15,587,978 | [['E02.319.267.050'], ['M01.060.057'], ['M01.060.116'], ['G17.035', 'L01.224.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['L01.224.160'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['E02.319.267.530.620'], ['D06.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Biochemically Silent Sympathetic Paraganglioma, Pheochromocytoma, or Metastatic Disease in SDHD Mutation Carriers. | CONTEXT: Current guidelines do not consistently recommend imaging beyond the head and neck region in succinate dehydrogenase subunit D (SDHD) mutation carriers as long as catecholamine metabolite levels are within the reference range.PARTICIPANTS: We report a series of 10 patients carrying pathogenic variants in the SD... | ['Adolescent', 'Adrenal Gland Neoplasms', 'Adult', 'Female', 'Heterozygote', 'Humans', 'Male', 'Middle Aged', 'Paraganglioma', 'Pheochromocytoma', 'Succinate Dehydrogenase', 'Young Adult'] | 31,194,241 | [['M01.060.057'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['M01.060.116'], ['G05.380.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.465.625.650.700', 'C04.557.580.625.650.700'], ['C04.557.465.625.650.700.725', 'C04.557.580.625.650.700.725'], ['D05.500.562.750.249.500',... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Using a new generation of classification system of antineoplastic drugs to guide Chinese medicine research]. | A new generation of classification system of antineoplastic drugs was put forward based on comparing the first with the second generation classification system of antineoplastic drugs. Antineoplastic drugs are divided into cytotoxic drug, cells biological behavior regulator, biological response modifier and biochemical... | ['Antineoplastic Agents', 'Drugs, Chinese Herbal', 'Humans', 'Medicine, Chinese Traditional', 'Phytotherapy'] | 19,960,986 | [['D27.505.954.248'], ['D20.215.784.500.350', 'D26.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.488.585.520', 'I01.076.201.450.654.558.520'], ['E02.190.755']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Proteomic analysis of the maternal protein restriction rat model for schizophrenia: identification of translational changes in hormonal signaling pathways and glutamate neurotransmission. | Previous studies have found that some first onset schizophrenia patients show signs of impaired insulin signaling. Also, epidemiological studies have shown that periods of suboptimal nutrition including protein deficiencies during pregnancy can lead to increased incidence of metabolic conditions and psychiatric disorde... | ['Animals', 'Blood Glucose', 'Brain', 'Female', 'Fetal Nutrition Disorders', 'Gene Expression Profiling', 'Glutamic Acid', 'Humans', 'Insulin', 'Pregnancy', 'Protein Deficiency', 'Proteome', 'Proteomics', 'Rats', 'Rats, Wistar', 'Schizophrenia', 'Serum', 'Signal Transduction', 'Synaptic Transmission'] | 23,071,080 | [['B01.050'], ['D09.947.875.359.448.500'], ['A08.186.211'], ['C13.703.277.677', 'C18.654.521.625'], ['E05.393.332'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G08.686.784.769'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Surgical treatment of T3 lung cancer invading the chest wall. | Lung tumors invading the chest wall are classed as belonging to the T3 group and are considered potentially resectable. Their management, however, is controversial, and extrapleural resection, when possible, is preferred to en bloc resection which is regarded as a far more invasive and dangerous operation. Five year su... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Bronchogenic', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Thoracic Neoplasms'] | 10,742,890 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.894.797.520.109.220', 'C08.381.540.140', 'C08.785.520.100.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['C04.697.645', 'C23.550.727.645'], ['E01.789.625'], ['C... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Teacher-student interpersonal relationships do change and affect academic motivation: a multilevel growth curve modelling. | BACKGROUND: Research has shown that the teacher-student interpersonal relationship (TSIR) is important for student motivation. Although TSIR has received a growing interest, there are only few studies that focus on changes and links between TSIR and student academic motivation in a longitudinal fashion in non-Western c... | ['Adolescent', 'Child', 'Cross-Cultural Comparison', 'Faculty', 'Female', 'Humans', 'Indonesia', 'Interpersonal Relations', 'Male', 'Models, Psychological', 'Motivation', 'Prospective Studies', 'Schools', 'Students', 'Time Factors'] | 24,266,772 | [['M01.060.057'], ['M01.060.406'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['M01.526.702.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.380', 'Z01.639.580'], ['F01.829.401'], ['E05.599.695'], ['F01.658', 'F01.752.543.500.750'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Assessment of total arsenic and arsenic species stability in alga samples and their aqueous extracts. | In order to achieve reliable information on speciation analysis, it is necessary to assess previously the species stability in the sample to analyse. Furthermore, in those cases where the sample treatment for species extraction is time-consuming, an assessment of the species integrity in the extracts is of paramount im... | ['Arsenic', 'Cell Extracts', 'Product Packaging', 'Sargassum', 'Temperature', 'Time Factors', 'Water'] | 18,585,162 | [['D01.268.513.249'], ['D20.777.162'], ['J01.576.761'], ['B01.750.600.725'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.910.857'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design. | The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. Rigorous pharmacokinetics/pharmacodynamics (PK/PD) assessment of ferret data has not been conducted, perhaps due to insufficient information ... | ['Administration, Oral', 'Animals', 'Antiviral Agents', 'Ferrets', 'Influenza A Virus, H3N2 Subtype', 'Influenza A Virus, H5N1 Subtype', 'Male', 'Models, Biological', 'Monte Carlo Method', 'Oseltamivir'] | 26,460,484 | [['E02.319.267.100'], ['B01.050'], ['D27.505.954.122.388'], ['B01.050.150.900.649.313.750.250.575.350'], ['B04.820.480.968.405.400.300'], ['B04.820.480.968.405.400.500'], ['E05.599.395'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['D02.065.064.525', 'D02.455.426.392.368.367.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Electrodiagnosis in spinal cord injured persons with new weakness or sensory loss: central and peripheral etiologies. | OBJECTIVE: To assess the prevalence and causes of late neurologic decline of persons with spinal cord injury (SCI).DESIGN: Retrospective review of persons with SCI over a 9-year period. Those with complaints of new weakness or sensory loss were grouped into three categories based on clinical examination, electrodiagnos... | ['Adult', 'Aged', 'Aged, 80 and over', 'Electrodiagnosis', 'Humans', 'Male', 'Middle Aged', 'Muscle Weakness', 'Neurologic Examination', 'Prevalence', 'Retrospective Studies', 'Sensation Disorders', 'Spinal Cord Injuries', 'Washington'] | 10,453,766 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.651.515', 'C10.597.613.593', 'C23.550.695', 'C23.888.592.608.593'], ['E01.370.376.550', 'E01.370.600.550'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Acromioclavicular dislocations: treatment by transfer of the conjoined tendon and distal end of the coracoid process to the clavicle. | A retrospective study of 23 acute and 6 chronic acromioclavicular dislocations treated by surgical transfer of the distal 1/2 inch of the coracoid process with the attached conjoined tendon of the coracobrachialis and short head of the biceps to the clavicle revealed 14 excellent, 14 good and one fair result. Results w... | ['Acromioclavicular Joint', 'Adolescent', 'Adult', 'Clavicle', 'Female', 'Humans', 'Joint Dislocations', 'Male', 'Methods', 'Middle Aged', 'Postoperative Complications', 'Retrospective Studies', 'Tendon Transfer'] | 709,927 | [['A02.835.583.032'], ['M01.060.057'], ['M01.060.116'], ['A02.835.232.087.227'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.518', 'C26.289'], ['E05.581'], ['M01.060.116.630'], ['C23.550.767'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.... | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Insulin dependence and pancreatic enzyme replacement therapy are independent prognostic factors for long-term survival after operation for chronic pancreatitis. | BACKGROUND: This retrospective, single-center, observational study on postoperative long-term results aims to define yet unknown factors for long-term outcome after operation for chronic pancreatitis.PATIENTS AND METHODS: We analyzed 147 consecutive patients operated for chronic pancreatitis from 2000 to 2011. Mean fol... | ['Adult', 'Aged', 'Body Weight', 'Enzyme Replacement Therapy', 'Female', 'Humans', 'Insulin Resistance', 'Male', 'Middle Aged', 'Pancreatitis, Chronic', 'Prognosis', 'Quality of Life', 'Reoperation', 'Retrospective Studies', 'Young Adult'] | 24,287,147 | [['M01.060.116'], ['M01.060.116.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E02.319.353.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['M01.060.116.630'], ['C06.689.750.830'], ['E0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Should the patella be resurfaced in total knee arthroplasty? Efficacy of patellar resurfacing. | To assess the long-term efficacy of patellar resurfacing, 100 knees were evaluated in 84 patients. The operations were performed between 1978 and 1982. The follow-up period ranged from 60 to 103 months. The diagnosis was degenerative joint disease (DJD) in 83%, rheumatoid arthritis in 12%, and miscellaneous in 5% of th... | ['Activities of Daily Living', 'Aged', 'Arthritis, Rheumatoid', 'Biomechanical Phenomena', 'Female', 'Follow-Up Studies', 'Humans', 'Knee Joint', 'Knee Prosthesis', 'Male', 'Middle Aged', 'Osteoarthritis', 'Patella', 'Prosthesis Design'] | 3,180,564 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['G01.154.090', 'G01.374.089'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Contribution of DNA conformation and topology in right-handed DNA wrapping by the Bacillus subtilis LrpC protein. | The Bacillus subtilis LrpC protein belongs to the Lrp/AsnC family of transcriptional regulators. It binds the upstream region of the lrpC gene and autoregulates its expression. In this study, we have dissected the mechanisms that govern the interaction of LrpC with DNA by electrophoretic mobility shift assay, electron ... | ['Bacillus subtilis', 'Bacterial Proteins', 'DNA, Bacterial', 'DNA-Binding Proteins', 'Leucine-Responsive Regulatory Protein', 'Models, Molecular', 'Nucleic Acid Conformation', 'Protein Binding', 'Transcription Factors'] | 12,458,218 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D12.776.097'], ['D13.444.308.212'], ['D12.776.260'], ['D12.776.260.527', 'D12.776.930.386'], ['E05.599.595'], ['G02.111.570.820.486', 'G05.360.580'], ['G02.111.679', 'G... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential cytopathogenesis of respiratory syncytial virus prototypic and clinical isolates in primary pediatric bronchial epithelial cells. | BACKGROUND: Human respiratory syncytial virus (RSV) causes severe respiratory disease in infants. Airway epithelial cells are the principle targets of RSV infection. However, the mechanisms by which it causes disease are poorly understood. Most RSV pathogenesis data are derived using laboratory-adapted prototypic strai... | ['Bronchiolitis, Viral', 'Chemokines', 'Child', 'Child, Preschool', 'Cytopathogenic Effect, Viral', 'Epithelial Cells', 'Humans', 'Infant', 'Respiratory Mucosa', 'Respiratory Syncytial Virus Infections', 'Respiratory Syncytial Virus, Human', 'Virulence', 'Virus Replication'] | 21,272,337 | [['C01.748.099.135.321', 'C01.925.109', 'C08.127.446.135.321', 'C08.381.495.146.135.321', 'C08.730.099.135.321'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.225.500.384.235', 'E05.200.500.384.235', 'E05.242.384.235', '... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Conversion from a calcineurin inhibitor to everolimus therapy in maintenance liver transplant recipients: a prospective, randomized, multicenter trial. | Calcineurin inhibitors (CNIs) contribute to renal dysfunction following liver transplantation. This prospective, randomized, multicenter, 6-month study (with an additional 6 months of follow-up) evaluated whether everolimus with CNI reduction or discontinuation would improve renal function in maintenance liver transpla... | ['Adolescent', 'Adult', 'Aged', 'Biopsy', 'Calcineurin Inhibitors', 'Everolimus', 'Female', 'Graft Rejection', 'Graft Survival', 'Humans', 'Immunosuppressive Agents', 'Liver Diseases', 'Liver Transplantation', 'Male', 'Middle Aged', 'Prospective Studies', 'Sirolimus', 'Treatment Outcome'] | 19,790,150 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D27.505.519.389.174'], ['D02.540.505.760.500'], ['G12.875.545.328'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. | Immune checkpoint inhibitors targeting the programmed cell death 1 receptor (PD-1) improve survival in a subset of patients with clear cell renal cell carcinoma (ccRCC). To identify genomic alterations in ccRCC that correlate with response to anti-PD-1 monotherapy, we performed whole-exome sequencing of metastatic ccRC... | ['B7-H1 Antigen', 'CTLA-4 Antigen', 'Carcinoma, Renal Cell', 'Chromosomal Proteins, Non-Histone', 'Cohort Studies', 'Exome', 'Gene Expression Profiling', 'Genomics', 'Humans', 'Immunotherapy', 'Kidney Neoplasms', 'Mutation', 'Programmed Cell Death 1 Receptor', 'Transcription Factors'] | 29,301,960 | [['D12.776.465.625', 'D12.776.467.150.300', 'D12.776.543.095.300', 'D23.050.301.285.400', 'D23.529.168.300'], ['D12.776.465.782', 'D12.776.543.750.705.222.750', 'D23.050.301.264.894.158', 'D23.101.100.894.158'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.35... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[The interpersonal alliance as the principle of psychoanalytic therapy]. | The classical opinion encountered in psychoanalytic psychotherapy is that the main curative agent is language, i.e. the information proffered by the analysand and the interpretations of the analyst. Over and against this view the author draws attention to the non-verbal structures in the twosome relationship between an... | ['Affect', 'Anxiety Disorders', 'Humans', 'Nonverbal Communication', 'Object Attachment', 'Physician-Patient Relations', 'Psychoanalytic Interpretation', 'Psychoanalytic Theory', 'Psychoanalytic Therapy', 'Psychophysiologic Disorders'] | 1,635,995 | [['F01.470.047'], ['F03.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.530', 'L01.143.649'], ['F02.739.794.624'], ['F01.829.401.650.675', 'N05.300.660.625'], ['F04.628'], ['F02.739.794'], ['F04.754.709'], ['C23.888.592.700']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Isolation and characterization of lysozyme-sensitive mutants of Staphylococcus aureus. | Four lysozyme-sensitive mutants were isolated after nitrosoguanidine mutagenesis of a lysozyme-insensitive strain of Staphylococcus aureus. One mutant was sufficiently effective for the isolation of macromolecules, such as plasmid deoxyribonucleic acids, from a cell after lysozyme-induced cell lysis. | ['Bacteriolysis', 'DNA, Bacterial', 'Muramidase', 'Mutation', 'Plasmids', 'Staphylococcus aureus'] | 7,440,506 | [['G06.099.115'], ['D13.444.308.212'], ['D08.811.277.450.642'], ['G05.365.590'], ['G05.360.600'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100', 'B03.510.400.790.750.100']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Targeted Deletion of Vesicular GABA Transporter from Retinal Horizontal Cells Eliminates Feedback Modulation of Photoreceptor Calcium Channels. | The cellular mechanisms underlying feedback signaling from horizontal cells to photoreceptors, which are important for the formation of receptive field surrounds of early visual neurons, remain unsettled. Mammalian horizontal cells express a complement of synaptic proteins that are necessary and sufficient for calcium-... | ['Animals', 'Calcium Channels', 'Connexins', 'Excitatory Amino Acid Agonists', 'Feedback, Physiological', 'Female', 'GABA-A Receptor Agonists', 'GTP-Binding Protein alpha Subunit, Gi2', 'Kainic Acid', 'Male', 'Membrane Potentials', 'Mice', 'Mice, Transgenic', 'Muscimol', 'Photoreceptor Cells', 'Retina', 'Retinal Horizo... | 27,022,629 | [['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D12.776.543.585.250'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['G07.410.732'], ['D27.505.519.625.240.200.500', 'D27.505.696.577.240.200.500'], ['D08.811.277.040.330.300.200.100.200.500', 'D12.644.360.360.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
How preschoolers and adults represent their joint action partner's behavior. | We investigated the cognitive mechanisms underlying turn-taking joint action in 42-month-old children (Experiment 1) and adults (Experiment 2) using a behavioral task of dressing a virtual bear together. We aimed to investigate how participants represent a partners' behavior, i.e., in terms of specific action kinematic... | ['Biomechanical Phenomena', 'Child, Preschool', 'Cooperative Behavior', 'Female', 'Humans', 'Male', 'Psychomotor Performance', 'Reaction Time', 'Young Adult'] | 29,067,520 | [['G01.154.090', 'G01.374.089'], ['M01.060.406.448'], ['F01.145.813.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['M01.060.116.815']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance. | The novel immunomodulator FTY720 down-modulates sphingosine-1-phosphate receptor 1 on lymphocytes at low nanomolar concentrations, thereby inhibiting sphingosine-1-phosphate receptor 1-dependent egress of lymphocytes from lymph nodes into efferent lymphatics and blood. At high micromolar concentration, FTY720 has been ... | ['Antineoplastic Agents', 'Apoptosis', 'Bone Marrow Cells', 'Caspases', 'Cell Growth Processes', 'Coculture Techniques', 'Drug Resistance, Neoplasm', 'Fingolimod Hydrochloride', 'Immunosuppressive Agents', 'Insulin-Like Growth Factor I', 'Interleukin-6', 'Membrane Potentials', 'Mitochondria', 'Multiple Myeloma', 'Propy... | 16,103,102 | [['D27.505.954.248'], ['G04.146.954.035'], ['A11.148', 'A15.378.316'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['G04.161', 'G07.345.249.410'], ['E05.481.500.374'], ['G07.690.773.984.395'], ['D02.033.100.700.350', 'D02.033.455.706.431', 'D02.092.063.7... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intrathoracic and multiple abdominal pheochromocytomas in von Hippel-Lindau disease. | A patient had von Hippel-Lindau disease, a functional intrathoracic paraganglioma (pheochromocytoma), bilateral adrenal pheochromocytomas, and a para-adrenal pheochromocytoma. Seven other members of the patient's family had features of von Hippel-Lindau disease and one, a cousin, had medullary carcinoma of the thyroid.... | ['Adrenal Gland Neoplasms', 'Adult', 'Angiomatosis', 'Diagnosis, Differential', 'Female', 'Humans', 'Neoplasms, Multiple Primary', 'Pedigree', 'Pheochromocytoma', 'Thoracic Neoplasms', 'von Hippel-Lindau Disease'] | 7,125,783 | [['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['M01.060.116'], ['C14.907.077'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.651'], ['E05.393.673'], ['C04.557.465.625.650.700.725', 'C04.557.580.625.650.700.725'], ['C04.588.894'], ['C10.562.925', 'C14.907.077.925', 'C16.131.077.245.750', 'C1... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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